C1ORF131

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein complex biogenesis (GO:0070271)4.86818209
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.68351728
3mitochondrial respiratory chain complex assembly (GO:0033108)4.67040839
4mitochondrial respiratory chain complex I assembly (GO:0032981)4.66712643
5NADH dehydrogenase complex assembly (GO:0010257)4.66712643
6mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.66712643
7establishment of protein localization to mitochondrial membrane (GO:0090151)4.47173273
8respiratory chain complex IV assembly (GO:0008535)4.34957853
9mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.33823671
10cytochrome complex assembly (GO:0017004)4.16003642
11energy coupled proton transport, down electrochemical gradient (GO:0015985)4.15203312
12ATP synthesis coupled proton transport (GO:0015986)4.15203312
13exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.92991624
14nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.90432685
15chaperone-mediated protein transport (GO:0072321)3.80662136
16respiratory electron transport chain (GO:0022904)3.77457291
17proteasome assembly (GO:0043248)3.74979832
18electron transport chain (GO:0022900)3.74445649
19DNA deamination (GO:0045006)3.73097563
20termination of RNA polymerase III transcription (GO:0006386)3.61244836
21transcription elongation from RNA polymerase III promoter (GO:0006385)3.61244836
22meiotic chromosome segregation (GO:0045132)3.60620328
23regulation of mitochondrial translation (GO:0070129)3.56915791
24pseudouridine synthesis (GO:0001522)3.53924737
25chromatin remodeling at centromere (GO:0031055)3.51655748
26behavioral response to nicotine (GO:0035095)3.48641994
27CENP-A containing nucleosome assembly (GO:0034080)3.44944281
28replication fork processing (GO:0031297)3.42001831
29protein neddylation (GO:0045116)3.40909642
30water-soluble vitamin biosynthetic process (GO:0042364)3.40802471
31protein K6-linked ubiquitination (GO:0085020)3.32201497
32maturation of 5.8S rRNA (GO:0000460)3.27627612
33response to pheromone (GO:0019236)3.26377273
34cullin deneddylation (GO:0010388)3.21218106
35rRNA modification (GO:0000154)3.21054671
36protein-cofactor linkage (GO:0018065)3.20952894
37regulation of mitotic spindle checkpoint (GO:1903504)3.16352036
38regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.16352036
39RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.15354506
40ribosomal small subunit assembly (GO:0000028)3.13533544
41maturation of SSU-rRNA (GO:0030490)3.13313126
42preassembly of GPI anchor in ER membrane (GO:0016254)3.12886842
43RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.10769847
44tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.10769847
45mannosylation (GO:0097502)3.10313617
46intracellular protein transmembrane import (GO:0044743)3.08130263
47spliceosomal snRNP assembly (GO:0000387)3.05988098
48kinetochore organization (GO:0051383)3.05533395
49DNA replication checkpoint (GO:0000076)3.05138406
50piRNA metabolic process (GO:0034587)3.02798161
51protein deneddylation (GO:0000338)2.96387364
52tRNA processing (GO:0008033)2.95172564
53cellular component biogenesis (GO:0044085)2.93658713
54kinetochore assembly (GO:0051382)2.93437661
55histone exchange (GO:0043486)2.87657361
56ribosomal large subunit biogenesis (GO:0042273)2.87543744
57negative regulation of DNA-dependent DNA replication (GO:2000104)2.86135653
58ubiquinone biosynthetic process (GO:0006744)2.84245783
59reciprocal DNA recombination (GO:0035825)2.82615365
60reciprocal meiotic recombination (GO:0007131)2.82615365
61histone mRNA metabolic process (GO:0008334)2.81975873
62rRNA methylation (GO:0031167)2.81529264
63regulation of meiosis I (GO:0060631)2.81287459
64translational termination (GO:0006415)2.80988832
65mitochondrial RNA metabolic process (GO:0000959)2.79375149
66centriole replication (GO:0007099)2.79000419
67rRNA metabolic process (GO:0016072)2.78784042
68synapsis (GO:0007129)2.77964705
69viral transcription (GO:0019083)2.76829141
70ribosomal small subunit biogenesis (GO:0042274)2.76419473
71rRNA processing (GO:0006364)2.75824556
72recombinational repair (GO:0000725)2.75421732
73double-strand break repair via homologous recombination (GO:0000724)2.75047315
74DNA double-strand break processing (GO:0000729)2.74945604
75negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.74797791
76peptidyl-histidine modification (GO:0018202)2.74249881
77inner mitochondrial membrane organization (GO:0007007)2.73813212
78GTP biosynthetic process (GO:0006183)2.69404321
79protein targeting to mitochondrion (GO:0006626)2.67666701
80protein localization to kinetochore (GO:0034501)2.66794610
81SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.66583908
82cotranslational protein targeting to membrane (GO:0006613)2.65736554
83translation (GO:0006412)2.63710805
84somatic diversification of immune receptors via somatic mutation (GO:0002566)2.62893156
85somatic hypermutation of immunoglobulin genes (GO:0016446)2.62893156
86tryptophan catabolic process (GO:0006569)2.62678770
87indole-containing compound catabolic process (GO:0042436)2.62678770
88indolalkylamine catabolic process (GO:0046218)2.62678770
89prenylation (GO:0097354)2.61664547
90protein prenylation (GO:0018342)2.61664547
91resolution of meiotic recombination intermediates (GO:0000712)2.61530932
92ubiquinone metabolic process (GO:0006743)2.61504067
93protein targeting to ER (GO:0045047)2.61068966
94positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.59805533
95establishment of protein localization to mitochondrion (GO:0072655)2.59140869
96kynurenine metabolic process (GO:0070189)2.58683389
97regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.58568675
98ncRNA metabolic process (GO:0034660)2.58283246
99transcription from mitochondrial promoter (GO:0006390)2.56354715
100neural tube formation (GO:0001841)2.55979469

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.60514132
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.24919083
3EST1_17652178_ChIP-ChIP_JURKAT_Human4.07461004
4HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.26056810
5MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.20990227
6ZNF274_21170338_ChIP-Seq_K562_Hela3.19812091
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.10112190
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.84196447
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.83194019
10VDR_23849224_ChIP-Seq_CD4+_Human2.58172827
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.56191669
12ELK1_19687146_ChIP-ChIP_HELA_Human2.55179510
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.48453084
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.37011391
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.24948627
16NOTCH1_21737748_ChIP-Seq_TLL_Human2.23153702
17FOXP3_21729870_ChIP-Seq_TREG_Human2.18711987
18VDR_22108803_ChIP-Seq_LS180_Human2.15434713
19MYC_18940864_ChIP-ChIP_HL60_Human2.13005145
20EWS_26573619_Chip-Seq_HEK293_Human2.09578303
21SRF_21415370_ChIP-Seq_HL-1_Mouse2.05333664
22MYC_18555785_ChIP-Seq_MESCs_Mouse2.00312399
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.93569532
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.87809458
25FUS_26573619_Chip-Seq_HEK293_Human1.86523232
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.81712172
27* ELF1_17652178_ChIP-ChIP_JURKAT_Human1.80770649
28FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.71216174
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.70304040
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.68637312
31PADI4_21655091_ChIP-ChIP_MCF-7_Human1.67501453
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.66661796
33E2F7_22180533_ChIP-Seq_HELA_Human1.55039944
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54482505
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.54180521
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.53737724
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.51462297
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.51192028
39EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.47545531
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46350734
41HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.45392707
42TP53_22573176_ChIP-Seq_HFKS_Human1.42692670
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40574408
44TTF2_22483619_ChIP-Seq_HELA_Human1.38719800
45* GABP_19822575_ChIP-Seq_HepG2_Human1.38570520
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38497041
47IGF1R_20145208_ChIP-Seq_DFB_Human1.37109898
48IRF1_19129219_ChIP-ChIP_H3396_Human1.36960670
49MYC_18358816_ChIP-ChIP_MESCs_Mouse1.36792309
50TAF15_26573619_Chip-Seq_HEK293_Human1.36101444
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.34841604
52MYC_19030024_ChIP-ChIP_MESCs_Mouse1.34487996
53MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33463538
54DCP1A_22483619_ChIP-Seq_HELA_Human1.33173298
55P300_19829295_ChIP-Seq_ESCs_Human1.33061838
56THAP11_20581084_ChIP-Seq_MESCs_Mouse1.32081142
57GBX2_23144817_ChIP-Seq_PC3_Human1.28397959
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27890731
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27476445
60ER_23166858_ChIP-Seq_MCF-7_Human1.26062466
61CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22589575
62FOXA1_25329375_ChIP-Seq_VCAP_Human1.17273522
63FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17273522
64RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17209712
65EZH2_27294783_Chip-Seq_NPCs_Mouse1.16212284
66EZH2_22144423_ChIP-Seq_EOC_Human1.15893156
67SOX2_19829295_ChIP-Seq_ESCs_Human1.15341693
68NANOG_19829295_ChIP-Seq_ESCs_Human1.15341693
69CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.14836615
70NFE2_27457419_Chip-Seq_LIVER_Mouse1.14787437
71BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.13480087
72TP63_19390658_ChIP-ChIP_HaCaT_Human1.12114219
73AR_20517297_ChIP-Seq_VCAP_Human1.11233381
74POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09379281
75SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09373560
76XRN2_22483619_ChIP-Seq_HELA_Human1.09328602
77KDM5A_27292631_Chip-Seq_BREAST_Human1.06823671
78E2F1_18555785_ChIP-Seq_MESCs_Mouse1.06819137
79GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05650372
80ELK1_22589737_ChIP-Seq_MCF10A_Human1.00624510
81MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.00620048
82NCOR_22424771_ChIP-Seq_293T_Human1.00230151
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99894507
84POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.99883066
85ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.96888991
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96430313
87CBP_20019798_ChIP-Seq_JUKART_Human0.96430313
88CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95097349
89ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94745995
90FOXM1_23109430_ChIP-Seq_U2OS_Human0.93088404
91CRX_20693478_ChIP-Seq_RETINA_Mouse0.93030717
92FOXA1_21572438_ChIP-Seq_LNCaP_Human0.92795717
93* E2F1_21310950_ChIP-Seq_MCF-7_Human0.91768640
94GATA3_21878914_ChIP-Seq_MCF-7_Human0.90383896
95BMI1_23680149_ChIP-Seq_NPCS_Mouse0.89462978
96MYC_19079543_ChIP-ChIP_MESCs_Mouse0.87981282
97HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.86768061
98RNF2_27304074_Chip-Seq_NSC_Mouse0.84883625
99CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.84837672
100PCGF2_27294783_Chip-Seq_NPCs_Mouse0.84436826

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair3.26655777
2MP0006292_abnormal_olfactory_placode3.11472398
3MP0008877_abnormal_DNA_methylation3.10525585
4MP0003718_maternal_effect3.01111319
5MP0003806_abnormal_nucleotide_metabolis2.67962519
6MP0000372_irregular_coat_pigmentation2.65198040
7MP0002938_white_spotting2.62380165
8MP0003693_abnormal_embryo_hatching2.53625269
9MP0010094_abnormal_chromosome_stability2.42344636
10MP0002102_abnormal_ear_morphology2.22662744
11MP0004147_increased_porphyrin_level2.14547656
12MP0006072_abnormal_retinal_apoptosis2.06315684
13MP0003195_calcinosis1.93848744
14MP0005551_abnormal_eye_electrophysiolog1.92282854
15MP0003136_yellow_coat_color1.90504999
16MP0003646_muscle_fatigue1.87208693
17MP0003786_premature_aging1.83945665
18MP0001986_abnormal_taste_sensitivity1.77670143
19MP0005646_abnormal_pituitary_gland1.73598131
20MP0001529_abnormal_vocalization1.73373004
21MP0002837_dystrophic_cardiac_calcinosis1.71225953
22MP0003787_abnormal_imprinting1.65691424
23MP0005253_abnormal_eye_physiology1.64802771
24MP0006036_abnormal_mitochondrial_physio1.64319959
25MP0004142_abnormal_muscle_tone1.62263273
26MP0000569_abnormal_digit_pigmentation1.60756793
27MP0001764_abnormal_homeostasis1.58318627
28MP0002736_abnormal_nociception_after1.57989101
29MP0003186_abnormal_redox_activity1.54690384
30MP0003111_abnormal_nucleus_morphology1.54373989
31MP0006035_abnormal_mitochondrial_morpho1.53849127
32MP0004957_abnormal_blastocyst_morpholog1.53059399
33MP0001968_abnormal_touch/_nociception1.51337509
34MP0002638_abnormal_pupillary_reflex1.48824851
35MP0002160_abnormal_reproductive_system1.46717930
36MP0005084_abnormal_gallbladder_morpholo1.45393282
37MP0008875_abnormal_xenobiotic_pharmacok1.44595411
38MP0000631_abnormal_neuroendocrine_gland1.43470650
39MP0003077_abnormal_cell_cycle1.42736756
40MP0005389_reproductive_system_phenotype1.41000515
41MP0002277_abnormal_respiratory_mucosa1.38435704
42MP0005075_abnormal_melanosome_morpholog1.37504780
43MP0001293_anophthalmia1.36498561
44MP0008057_abnormal_DNA_replication1.35227177
45MP0002210_abnormal_sex_determination1.32245798
46MP0001929_abnormal_gametogenesis1.30689873
47MP0002163_abnormal_gland_morphology1.28987629
48MP0008995_early_reproductive_senescence1.28033233
49MP0005379_endocrine/exocrine_gland_phen1.25296913
50MP0008872_abnormal_physiological_respon1.25130534
51MP0005174_abnormal_tail_pigmentation1.23355403
52MP0001919_abnormal_reproductive_system1.23159021
53MP0002095_abnormal_skin_pigmentation1.21779040
54MP0008789_abnormal_olfactory_epithelium1.21312791
55MP0003880_abnormal_central_pattern1.21086730
56MP0000653_abnormal_sex_gland1.17849106
57MP0003011_delayed_dark_adaptation1.17097589
58MP0008932_abnormal_embryonic_tissue1.15216355
59MP0005410_abnormal_fertilization1.13888642
60MP0001485_abnormal_pinna_reflex1.10357866
61MP0001145_abnormal_male_reproductive1.09471792
62MP0003567_abnormal_fetal_cardiomyocyte1.08958734
63MP0009046_muscle_twitch1.07797798
64MP0003890_abnormal_embryonic-extraembry1.07198842
65MP0005645_abnormal_hypothalamus_physiol1.05465558
66MP0002234_abnormal_pharynx_morphology1.05311604
67MP0004885_abnormal_endolymph1.04235266
68MP0004043_abnormal_pH_regulation1.04185659
69MP0006276_abnormal_autonomic_nervous1.03506179
70MP0003698_abnormal_male_reproductive1.02222559
71MP0001119_abnormal_female_reproductive1.00073250
72MP0004133_heterotaxia0.97548437
73MP0000427_abnormal_hair_cycle0.96900986
74MP0002751_abnormal_autonomic_nervous0.96338181
75MP0001324_abnormal_eye_pigmentation0.93639922
76MP0008007_abnormal_cellular_replicative0.93492745
77MP0005408_hypopigmentation0.93266965
78MP0004145_abnormal_muscle_electrophysio0.92712332
79MP0004215_abnormal_myocardial_fiber0.90126738
80MP0001984_abnormal_olfaction0.87412782
81MP0000647_abnormal_sebaceous_gland0.87230350
82MP0009745_abnormal_behavioral_response0.84029079
83MP0005195_abnormal_posterior_eye0.82378743
84MP0002928_abnormal_bile_duct0.81242390
85MP0005395_other_phenotype0.81109488
86MP0005187_abnormal_penis_morphology0.78679726
87MP0005332_abnormal_amino_acid0.78256442
88MP0003937_abnormal_limbs/digits/tail_de0.77690567
89MP0009697_abnormal_copulation0.77628574
90MP0002272_abnormal_nervous_system0.76475420
91MP0005085_abnormal_gallbladder_physiolo0.76442046
92MP0003121_genomic_imprinting0.76062619
93MP0001905_abnormal_dopamine_level0.75266211
94MP0002138_abnormal_hepatobiliary_system0.75076895
95MP0002876_abnormal_thyroid_physiology0.74330680
96MP0004742_abnormal_vestibular_system0.74257392
97MP0005391_vision/eye_phenotype0.73850498
98MP0009379_abnormal_foot_pigmentation0.72776448
99MP0002653_abnormal_ependyma_morphology0.71047288
100MP0010386_abnormal_urinary_bladder0.70713015

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.97694734
2Increased hepatocellular lipid droplets (HP:0006565)3.70367993
3Mitochondrial inheritance (HP:0001427)3.69539673
4Acute encephalopathy (HP:0006846)3.62166468
5Increased CSF lactate (HP:0002490)3.56178932
6Lipid accumulation in hepatocytes (HP:0006561)3.55516580
7Pancreatic cysts (HP:0001737)3.53281311
8Progressive macrocephaly (HP:0004481)3.51203041
9Abnormal mitochondria in muscle tissue (HP:0008316)3.50826396
10Abnormality of midbrain morphology (HP:0002418)3.48339115
11Molar tooth sign on MRI (HP:0002419)3.48339115
12Abnormal number of erythroid precursors (HP:0012131)3.21798471
13Hepatocellular necrosis (HP:0001404)3.13930214
14Pancreatic fibrosis (HP:0100732)3.05544309
15Abnormality of the pons (HP:0007361)2.99814973
16Type II lissencephaly (HP:0007260)2.98437143
17Hepatic necrosis (HP:0002605)2.96783652
18Abnormality of cells of the erythroid lineage (HP:0012130)2.96306624
19Hypoplasia of the pons (HP:0012110)2.92864802
203-Methylglutaconic aciduria (HP:0003535)2.86164364
21Abnormality of the renal cortex (HP:0011035)2.85737290
22Renal Fanconi syndrome (HP:0001994)2.79484393
23Renal cortical cysts (HP:0000803)2.77804769
24True hermaphroditism (HP:0010459)2.77753616
25Nephronophthisis (HP:0000090)2.72247604
26Birth length less than 3rd percentile (HP:0003561)2.68223642
27Cerebral edema (HP:0002181)2.62209625
28Increased serum lactate (HP:0002151)2.56168759
29Abnormality of alanine metabolism (HP:0010916)2.54156664
30Hyperalaninemia (HP:0003348)2.54156664
31Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.54156664
32Cerebellar dysplasia (HP:0007033)2.52408594
33Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.51961173
34Pendular nystagmus (HP:0012043)2.48307785
35Abnormality of the renal medulla (HP:0100957)2.44069833
36Optic disc pallor (HP:0000543)2.39752378
37Congenital, generalized hypertrichosis (HP:0004540)2.37558296
38Lactic acidosis (HP:0003128)2.30011044
39Medial flaring of the eyebrow (HP:0010747)2.29286265
40Exertional dyspnea (HP:0002875)2.26672288
41Congenital stationary night blindness (HP:0007642)2.22395942
42Increased intramyocellular lipid droplets (HP:0012240)2.21192656
43Type I transferrin isoform profile (HP:0003642)2.16330864
44Abnormal biliary tract physiology (HP:0012439)2.13815592
45Bile duct proliferation (HP:0001408)2.13815592
46Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.11770730
47Colon cancer (HP:0003003)2.06912646
48Oligodactyly (hands) (HP:0001180)2.05948915
49Aplasia/Hypoplasia of the uvula (HP:0010293)2.05261207
50Abnormality of renal resorption (HP:0011038)2.03563880
51Meckel diverticulum (HP:0002245)2.02532954
52Reticulocytopenia (HP:0001896)2.00522347
53Leukodystrophy (HP:0002415)2.00353255
54Patellar aplasia (HP:0006443)2.00164703
55Abnormal protein glycosylation (HP:0012346)1.99217576
56Abnormal glycosylation (HP:0012345)1.99217576
57Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.99217576
58Abnormal protein N-linked glycosylation (HP:0012347)1.99217576
59Decreased electroretinogram (ERG) amplitude (HP:0000654)1.98849017
60Hyperglycinemia (HP:0002154)1.98457868
61Attenuation of retinal blood vessels (HP:0007843)1.97764320
62Abolished electroretinogram (ERG) (HP:0000550)1.97753122
63Respiratory failure (HP:0002878)1.97050197
64Retinal dysplasia (HP:0007973)1.96461612
65Supernumerary spleens (HP:0009799)1.96447219
66Abnormality of the ileum (HP:0001549)1.95970033
67Abnormality of urine glucose concentration (HP:0011016)1.95882503
68Glycosuria (HP:0003076)1.95882503
69Methylmalonic acidemia (HP:0002912)1.94675728
70Macrocytic anemia (HP:0001972)1.93160572
71Hyperglycinuria (HP:0003108)1.92793724
72Large for gestational age (HP:0001520)1.91910099
73Aplasia/hypoplasia of the uterus (HP:0008684)1.91425558
74Aplasia/Hypoplasia of the tibia (HP:0005772)1.90659258
75Aplasia/Hypoplasia of the patella (HP:0006498)1.90373910
76Lethargy (HP:0001254)1.89183228
77Sclerocornea (HP:0000647)1.87474774
78Hyperventilation (HP:0002883)1.87278928
79Respiratory difficulties (HP:0002880)1.84863998
80CNS demyelination (HP:0007305)1.84395255
81Methylmalonic aciduria (HP:0012120)1.83733469
82Chromsome breakage (HP:0040012)1.83710308
83Decreased activity of mitochondrial respiratory chain (HP:0008972)1.81383097
84Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.81383097
85Short tibia (HP:0005736)1.79124268
86Increased muscle lipid content (HP:0009058)1.79111141
87Lissencephaly (HP:0001339)1.77531299
88Chromosomal breakage induced by crosslinking agents (HP:0003221)1.76651983
89Abnormality of the preputium (HP:0100587)1.75991007
90Exercise intolerance (HP:0003546)1.74053524
91Cystic liver disease (HP:0006706)1.73955325
92Concave nail (HP:0001598)1.73878246
93Chronic hepatic failure (HP:0100626)1.73719918
94Abnormality of chromosome stability (HP:0003220)1.73690383
95Aplasia/Hypoplasia of the tongue (HP:0010295)1.70136853
96Abnormality of serum amino acid levels (HP:0003112)1.69935756
97Abnormal rod and cone electroretinograms (HP:0008323)1.68560469
98Abnormality of the labia minora (HP:0012880)1.67295370
99Pancytopenia (HP:0001876)1.67017232
100Progressive inability to walk (HP:0002505)1.66631720

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR1B3.33193511
2INSRR3.20341524
3FRK3.09821483
4ZAK2.81469644
5BUB12.73879870
6TAOK32.64146805
7VRK22.63387286
8NUAK12.58333883
9STK162.45054856
10ACVR1B2.23441394
11WNK32.11502732
12VRK12.01109111
13SRPK11.96099639
14MAP4K21.91229386
15PBK1.82162040
16WNK41.76920725
17MST41.75608903
18ADRBK21.72552635
19TLK11.71782743
20PLK41.68123912
21CDC71.64838013
22TXK1.60498983
23EIF2AK11.53163113
24GRK11.52069864
25BRSK21.50974867
26PLK31.49991538
27WEE11.44428038
28EIF2AK31.42921737
29TRIM281.41887956
30MKNK21.38608507
31STK391.37355317
32TNIK1.26947861
33PDK21.26033367
34PINK11.25925664
35NEK11.20893577
36CASK1.20424835
37ERBB31.14847266
38TGFBR11.12303205
39MAPK131.10630308
40OXSR11.06919841
41CCNB11.04656867
42PLK11.04509528
43MKNK11.03837209
44MARK31.03692039
45TAF11.02393341
46MAP3K40.95883344
47TTK0.95646468
48PNCK0.94816396
49TSSK60.94640203
50BCKDK0.86177170
51DYRK20.82225297
52CHEK20.80446090
53STK38L0.78807083
54CAMKK20.78334831
55NME10.76288184
56ATR0.76069511
57ADRBK10.75402468
58RPS6KA50.74603162
59NEK20.73013812
60CDK80.71083479
61CSNK1G10.68298943
62PIM10.66052590
63AURKB0.64356603
64STK100.63727830
65CDK30.63725928
66PLK20.63420366
67MAPKAPK50.62844119
68CSNK1G30.62818806
69EIF2AK20.62133892
70CSNK1G20.58206371
71STK30.57606485
72PRKCG0.56312342
73BCR0.56079994
74PAK30.53578278
75IKBKB0.51863160
76MAP2K70.51618086
77BRSK10.51351224
78TEC0.51040810
79CSNK2A10.50600391
80MAPKAPK30.50559209
81AURKA0.49152554
82ATM0.48497860
83CSNK2A20.47834889
84PASK0.47357794
85BMPR20.47109012
86PKN10.46947774
87PRKCI0.46584224
88CSNK1A1L0.44350146
89TNK20.43849413
90MUSK0.41388672
91PRKCE0.39815273
92GRK70.37965314
93CSNK1A10.37959349
94RPS6KB20.37057089
95CHEK10.35046874
96NLK0.33322363
97PRKCQ0.32969468
98CLK10.32772173
99CSNK1E0.32087655
100PRKACA0.30095056

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.57183349
2Ribosome_Homo sapiens_hsa030103.36677680
3RNA polymerase_Homo sapiens_hsa030203.08942365
4Proteasome_Homo sapiens_hsa030503.02004415
5Parkinsons disease_Homo sapiens_hsa050122.90162895
6Protein export_Homo sapiens_hsa030602.74286661
7Homologous recombination_Homo sapiens_hsa034402.57197103
8Basal transcription factors_Homo sapiens_hsa030222.28679754
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.27574770
10Mismatch repair_Homo sapiens_hsa034302.23965510
11RNA degradation_Homo sapiens_hsa030182.10956724
12Fanconi anemia pathway_Homo sapiens_hsa034602.05840660
13Huntingtons disease_Homo sapiens_hsa050162.05627682
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.05507374
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.95716607
16DNA replication_Homo sapiens_hsa030301.95041952
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.82392615
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.78901659
19Alzheimers disease_Homo sapiens_hsa050101.78249075
20Nucleotide excision repair_Homo sapiens_hsa034201.68590987
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.68316259
22One carbon pool by folate_Homo sapiens_hsa006701.66637887
23Pyrimidine metabolism_Homo sapiens_hsa002401.60712480
24Non-homologous end-joining_Homo sapiens_hsa034501.59340720
25Base excision repair_Homo sapiens_hsa034101.54871676
26Spliceosome_Homo sapiens_hsa030401.51308650
27Propanoate metabolism_Homo sapiens_hsa006401.50809836
28RNA transport_Homo sapiens_hsa030131.47887346
29Phototransduction_Homo sapiens_hsa047441.44490774
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.42432063
31Butanoate metabolism_Homo sapiens_hsa006501.40639096
32Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.40146504
33Selenocompound metabolism_Homo sapiens_hsa004501.37703787
34Nitrogen metabolism_Homo sapiens_hsa009101.20352273
35Purine metabolism_Homo sapiens_hsa002301.19115179
36Linoleic acid metabolism_Homo sapiens_hsa005911.17798103
37Caffeine metabolism_Homo sapiens_hsa002321.17598031
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.17592994
39Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.16207544
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13301721
41Pentose and glucuronate interconversions_Homo sapiens_hsa000401.12319814
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.12070858
43Cardiac muscle contraction_Homo sapiens_hsa042601.11228263
44Peroxisome_Homo sapiens_hsa041461.10405266
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.09982612
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.08326601
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.05645643
48Folate biosynthesis_Homo sapiens_hsa007901.01687411
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.01579163
50Steroid biosynthesis_Homo sapiens_hsa001001.00646174
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.00199364
52Steroid hormone biosynthesis_Homo sapiens_hsa001400.95643692
53Cell cycle_Homo sapiens_hsa041100.93253018
54Chemical carcinogenesis_Homo sapiens_hsa052040.89533246
55Tryptophan metabolism_Homo sapiens_hsa003800.85587613
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.84935266
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84497746
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82443727
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.82186939
60Collecting duct acid secretion_Homo sapiens_hsa049660.81924638
61Metabolic pathways_Homo sapiens_hsa011000.79818675
62Regulation of autophagy_Homo sapiens_hsa041400.79460290
63Ether lipid metabolism_Homo sapiens_hsa005650.76288676
64Sulfur relay system_Homo sapiens_hsa041220.76246554
65Drug metabolism - other enzymes_Homo sapiens_hsa009830.75624740
66Vitamin digestion and absorption_Homo sapiens_hsa049770.75054491
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74993150
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74670125
69Retinol metabolism_Homo sapiens_hsa008300.74504493
70Asthma_Homo sapiens_hsa053100.70483494
71Sulfur metabolism_Homo sapiens_hsa009200.70281344
72Pyruvate metabolism_Homo sapiens_hsa006200.66283564
73Intestinal immune network for IgA production_Homo sapiens_hsa046720.65477595
74Fatty acid elongation_Homo sapiens_hsa000620.64616352
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60975821
76Glutathione metabolism_Homo sapiens_hsa004800.58308444
77Arachidonic acid metabolism_Homo sapiens_hsa005900.55148048
78Olfactory transduction_Homo sapiens_hsa047400.54988688
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54939857
80p53 signaling pathway_Homo sapiens_hsa041150.53010062
81Primary immunodeficiency_Homo sapiens_hsa053400.49309153
82mRNA surveillance pathway_Homo sapiens_hsa030150.46337584
83Nicotine addiction_Homo sapiens_hsa050330.44437276
84Oocyte meiosis_Homo sapiens_hsa041140.41278516
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39738228
86Fat digestion and absorption_Homo sapiens_hsa049750.35283732
87Allograft rejection_Homo sapiens_hsa053300.34955608
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33399976
89beta-Alanine metabolism_Homo sapiens_hsa004100.32372530
90Type I diabetes mellitus_Homo sapiens_hsa049400.31629757
91Taste transduction_Homo sapiens_hsa047420.31283972
92Cyanoamino acid metabolism_Homo sapiens_hsa004600.30466977
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29915229
94Autoimmune thyroid disease_Homo sapiens_hsa053200.29740506
95Systemic lupus erythematosus_Homo sapiens_hsa053220.27639778
96Ovarian steroidogenesis_Homo sapiens_hsa049130.27580802
97Graft-versus-host disease_Homo sapiens_hsa053320.26565830
98Fatty acid degradation_Homo sapiens_hsa000710.22833015
99Epstein-Barr virus infection_Homo sapiens_hsa051690.21272454
100Mineral absorption_Homo sapiens_hsa049780.19442326

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