C1ORF127

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of glycolytic process (GO:0045821)5.58043957
2regulation of hexokinase activity (GO:1903299)5.50213265
3regulation of glucokinase activity (GO:0033131)5.50213265
4respiratory chain complex IV assembly (GO:0008535)4.56973608
5nitric oxide mediated signal transduction (GO:0007263)4.24477400
6endocrine pancreas development (GO:0031018)4.20922465
7lactate metabolic process (GO:0006089)4.09728243
8negative regulation of cytosolic calcium ion concentration (GO:0051481)4.01595302
9behavioral response to nicotine (GO:0035095)3.99369618
10regulation of type B pancreatic cell apoptotic process (GO:2000674)3.96849246
11cytochrome complex assembly (GO:0017004)3.92042231
12response to pheromone (GO:0019236)3.71389495
13cellular ketone body metabolic process (GO:0046950)3.70403473
14positive regulation of respiratory burst (GO:0060267)3.69349132
15negative regulation of protein oligomerization (GO:0032460)3.62528046
16fucose catabolic process (GO:0019317)3.59427702
17L-fucose metabolic process (GO:0042354)3.59427702
18L-fucose catabolic process (GO:0042355)3.59427702
19insulin secretion (GO:0030073)3.50857595
20negative regulation of acute inflammatory response (GO:0002674)3.49645725
21water-soluble vitamin biosynthetic process (GO:0042364)3.48871704
22negative regulation of gluconeogenesis (GO:0045721)3.47123781
23signal peptide processing (GO:0006465)3.46001309
24platelet dense granule organization (GO:0060155)3.35300303
25positive regulation of peptide hormone secretion (GO:0090277)3.26891749
26ketone body metabolic process (GO:1902224)3.26805842
27positive regulation of insulin secretion (GO:0032024)3.19187430
28regulation of energy homeostasis (GO:2000505)3.18202713
29positive regulation of peptide secretion (GO:0002793)3.12690154
30inositol phosphate catabolic process (GO:0071545)3.12268513
31fatty acid homeostasis (GO:0055089)3.12005502
32detection of light stimulus involved in visual perception (GO:0050908)3.02921915
33detection of light stimulus involved in sensory perception (GO:0050962)3.02921915
34positive regulation of glycogen biosynthetic process (GO:0045725)3.01632746
35negative regulation of hormone biosynthetic process (GO:0032353)3.01298055
36protein K11-linked deubiquitination (GO:0035871)3.01279791
37calcium ion import (GO:0070509)2.97817384
38regulation of glycolytic process (GO:0006110)2.97562562
39indolalkylamine metabolic process (GO:0006586)2.87961043
40glycerophospholipid catabolic process (GO:0046475)2.86605349
41L-alpha-amino acid transmembrane transport (GO:1902475)2.85994830
42protein K6-linked ubiquitination (GO:0085020)2.85427823
43alanine transport (GO:0032328)2.83350847
44proline transport (GO:0015824)2.82894586
45keratinocyte development (GO:0003334)2.81678454
46auditory receptor cell stereocilium organization (GO:0060088)2.80494162
47regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.77208605
48detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.76808178
49protein complex biogenesis (GO:0070271)2.76749914
50polyol catabolic process (GO:0046174)2.76481745
51DNA deamination (GO:0045006)2.70262889
52positive regulation of protein autophosphorylation (GO:0031954)2.70141551
53axoneme assembly (GO:0035082)2.69564226
54regulation of insulin secretion (GO:0050796)2.67847737
55regulation of acrosome reaction (GO:0060046)2.66914643
56negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.66674878
57kidney morphogenesis (GO:0060993)2.65327452
58positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.61113627
59phosphorylated carbohydrate dephosphorylation (GO:0046838)2.60598942
60inositol phosphate dephosphorylation (GO:0046855)2.60598942
61adaptation of signaling pathway (GO:0023058)2.60210589
62acrosome reaction (GO:0007340)2.59615042
63positive regulation of hormone secretion (GO:0046887)2.59322552
64membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.58067212
65positive regulation of glycogen metabolic process (GO:0070875)2.57674104
66piRNA metabolic process (GO:0034587)2.57516285
67G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.55309857
68regulation of peptide hormone secretion (GO:0090276)2.54481420
69startle response (GO:0001964)2.50845377
70regulation of peptide secretion (GO:0002791)2.48836695
71regulation of action potential (GO:0098900)2.47850119
72regulation of calcium ion-dependent exocytosis (GO:0017158)2.47363533
73protein polyglutamylation (GO:0018095)2.47304805
74positive regulation of meiosis (GO:0045836)2.46838031
75phasic smooth muscle contraction (GO:0014821)2.46835143
76exocrine pancreas development (GO:0031017)2.45044769
77negative regulation of hormone metabolic process (GO:0032351)2.45015796
78neuronal action potential (GO:0019228)2.44895368
79xenobiotic catabolic process (GO:0042178)2.43424836
80indole-containing compound catabolic process (GO:0042436)2.40578783
81indolalkylamine catabolic process (GO:0046218)2.40578783
82tryptophan catabolic process (GO:0006569)2.40578783
83mitochondrial respiratory chain complex assembly (GO:0033108)2.39879508
84positive regulation of prostaglandin secretion (GO:0032308)2.38496663
85type B pancreatic cell development (GO:0003323)2.38112144
86regulation of skeletal muscle contraction (GO:0014819)2.37609125
87regulation of feeding behavior (GO:0060259)2.37185902
88chemosensory behavior (GO:0007635)2.36168976
89negative regulation of telomere maintenance (GO:0032205)2.35767042
90kynurenine metabolic process (GO:0070189)2.34089674
91prenylation (GO:0097354)2.33964936
92protein prenylation (GO:0018342)2.33964936
93prostate gland growth (GO:0060736)2.33656533
94regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.33154422
95calcium ion-dependent exocytosis (GO:0017156)2.33110842
96mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.33081673
97mitochondrial respiratory chain complex I assembly (GO:0032981)2.33081673
98NADH dehydrogenase complex assembly (GO:0010257)2.33081673
99regulation of carbohydrate catabolic process (GO:0043470)2.32327415
100regulation of cellular carbohydrate catabolic process (GO:0043471)2.32327415

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.52551111
2ZNF274_21170338_ChIP-Seq_K562_Hela3.13609897
3GBX2_23144817_ChIP-Seq_PC3_Human2.90406100
4VDR_22108803_ChIP-Seq_LS180_Human2.71522108
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.53740176
6IGF1R_20145208_ChIP-Seq_DFB_Human2.50653260
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.43821675
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.34946433
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.20211080
10* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.08631134
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.05308095
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.02991699
13CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97665639
14PCGF2_27294783_Chip-Seq_ESCs_Mouse1.93353162
15P300_19829295_ChIP-Seq_ESCs_Human1.90782415
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.88690656
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.85935312
18ER_23166858_ChIP-Seq_MCF-7_Human1.84630140
19TAF15_26573619_Chip-Seq_HEK293_Human1.83063471
20BCAT_22108803_ChIP-Seq_LS180_Human1.81058175
21FUS_26573619_Chip-Seq_HEK293_Human1.67074189
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.62662248
23EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.62557239
24SMAD4_21799915_ChIP-Seq_A2780_Human1.60183942
25PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.58110646
26SUZ12_27294783_Chip-Seq_NPCs_Mouse1.57067156
27EWS_26573619_Chip-Seq_HEK293_Human1.56797376
28SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56516209
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.56361801
30NFE2_27457419_Chip-Seq_LIVER_Mouse1.55430248
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.55264581
32AR_25329375_ChIP-Seq_VCAP_Human1.55252189
33RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52469181
34UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.52416117
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.50147570
36EZH2_27294783_Chip-Seq_NPCs_Mouse1.49604270
37TP53_22573176_ChIP-Seq_HFKS_Human1.47406453
38CBP_20019798_ChIP-Seq_JUKART_Human1.46489291
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46489291
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.45899281
41SOX2_19829295_ChIP-Seq_ESCs_Human1.43856843
42NANOG_19829295_ChIP-Seq_ESCs_Human1.43856843
43TCF4_23295773_ChIP-Seq_U87_Human1.43853648
44MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43182618
45STAT3_23295773_ChIP-Seq_U87_Human1.40858995
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40022623
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39640037
48NANOG_18555785_Chip-Seq_ESCs_Mouse1.39467337
49REST_21632747_ChIP-Seq_MESCs_Mouse1.38898138
50EZH2_22144423_ChIP-Seq_EOC_Human1.37853852
51CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.36030363
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34743418
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.33563373
54NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33153291
55GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.32785360
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32471150
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.31906936
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.31811097
59EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.31748534
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31552048
61TCF4_22108803_ChIP-Seq_LS180_Human1.30976466
62POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30933190
63TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30933190
64CRX_20693478_ChIP-Seq_RETINA_Mouse1.30466111
65TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29220993
66P53_22387025_ChIP-Seq_ESCs_Mouse1.29016335
67CDX2_22108803_ChIP-Seq_LS180_Human1.27841753
68FLI1_21867929_ChIP-Seq_TH2_Mouse1.26080889
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24036834
70FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23448982
71FOXA1_25329375_ChIP-Seq_VCAP_Human1.23448982
72SMAD4_21741376_ChIP-Seq_EPCs_Human1.21921907
73PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19285650
74SUZ12_18555785_Chip-Seq_ESCs_Mouse1.18601077
75RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.17936213
76STAT3_18555785_Chip-Seq_ESCs_Mouse1.16707201
77* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16597981
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16469319
79RUNX2_22187159_ChIP-Seq_PCA_Human1.15572469
80SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.15518420
81NOTCH1_21737748_ChIP-Seq_TLL_Human1.14952699
82PRDM14_20953172_ChIP-Seq_ESCs_Human1.14249910
83EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.13198687
84FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12134375
85CMYC_18555785_Chip-Seq_ESCs_Mouse1.11994845
86E2F1_18555785_Chip-Seq_ESCs_Mouse1.11690283
87OCT4_21477851_ChIP-Seq_ESCs_Mouse1.11565429
88P300_18555785_Chip-Seq_ESCs_Mouse1.10503778
89MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10139350
90TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05288973
91OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04605086
92AR_20517297_ChIP-Seq_VCAP_Human1.03560112
93CTCF_18555785_Chip-Seq_ESCs_Mouse1.03320169
94SOX2_21211035_ChIP-Seq_LN229_Gbm1.03081808
95ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02557667
96NCOR_22424771_ChIP-Seq_293T_Human1.02020873
97REST_18959480_ChIP-ChIP_MESCs_Mouse1.01629248
98HTT_18923047_ChIP-ChIP_STHdh_Human0.99374457
99SOX2_18555785_Chip-Seq_ESCs_Mouse0.98733364
100SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.98307134

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis5.10875128
2MP0003787_abnormal_imprinting3.61015910
3MP0002837_dystrophic_cardiac_calcinosis3.30712289
4MP0008877_abnormal_DNA_methylation3.27898780
5MP0003283_abnormal_digestive_organ3.11281216
6MP0004145_abnormal_muscle_electrophysio2.74478310
7MP0003646_muscle_fatigue2.65308497
8MP0002909_abnormal_adrenal_gland2.32536538
9MP0002102_abnormal_ear_morphology2.31216713
10MP0006072_abnormal_retinal_apoptosis2.25881900
11MP0002693_abnormal_pancreas_physiology2.24884365
12MP0005551_abnormal_eye_electrophysiolog2.09728016
13MP0002876_abnormal_thyroid_physiology2.05718692
14MP0009046_muscle_twitch2.02275210
15MP0000569_abnormal_digit_pigmentation1.88998341
16MP0003122_maternal_imprinting1.87637478
17MP0001944_abnormal_pancreas_morphology1.79635997
18MP0005379_endocrine/exocrine_gland_phen1.78041206
19MP0004043_abnormal_pH_regulation1.76765543
20MP0005253_abnormal_eye_physiology1.73945510
21MP0005645_abnormal_hypothalamus_physiol1.69253026
22MP0009745_abnormal_behavioral_response1.66804191
23MP0001986_abnormal_taste_sensitivity1.65272101
24MP0003011_delayed_dark_adaptation1.64592645
25MP0002638_abnormal_pupillary_reflex1.58312869
26MP0003172_abnormal_lysosome_physiology1.50147712
27MP0005075_abnormal_melanosome_morpholog1.49972160
28MP0009780_abnormal_chondrocyte_physiolo1.49313307
29MP0004885_abnormal_endolymph1.48179245
30MP0002822_catalepsy1.47323669
31MP0003121_genomic_imprinting1.47271725
32MP0008872_abnormal_physiological_respon1.46531456
33MP0005646_abnormal_pituitary_gland1.45558389
34MP0002272_abnormal_nervous_system1.43783450
35MP0002078_abnormal_glucose_homeostasis1.42705165
36MP0006036_abnormal_mitochondrial_physio1.41431456
37MP0002277_abnormal_respiratory_mucosa1.40738233
38MP0002163_abnormal_gland_morphology1.40675246
39MP0001968_abnormal_touch/_nociception1.38351413
40MP0002064_seizures1.37612188
41MP0001501_abnormal_sleep_pattern1.34095962
42MP0004142_abnormal_muscle_tone1.31991335
43MP0003880_abnormal_central_pattern1.27873143
44MP0002928_abnormal_bile_duct1.26144647
45MP0004036_abnormal_muscle_relaxation1.24003494
46MP0005084_abnormal_gallbladder_morpholo1.22027124
47MP0004147_increased_porphyrin_level1.18811309
48MP0004133_heterotaxia1.18728163
49MP0010386_abnormal_urinary_bladder1.18400364
50MP0004215_abnormal_myocardial_fiber1.17716492
51MP0004270_analgesia1.16705405
52MP0010329_abnormal_lipoprotein_level1.15738450
53MP0002938_white_spotting1.15510969
54MP0003045_fibrosis1.11064981
55MP0000749_muscle_degeneration1.09814394
56MP0005332_abnormal_amino_acid1.09020551
57MP0002557_abnormal_social/conspecific_i1.07484974
58MP0002736_abnormal_nociception_after1.05924718
59MP0004924_abnormal_behavior1.03725230
60MP0005386_behavior/neurological_phenoty1.03725230
61MP0006276_abnormal_autonomic_nervous1.02807273
62MP0005220_abnormal_exocrine_pancreas1.02211680
63MP0000631_abnormal_neuroendocrine_gland1.01703566
64MP0002254_reproductive_system_inflammat1.01094139
65MP0002229_neurodegeneration0.98567012
66MP0001486_abnormal_startle_reflex0.96528742
67MP0002572_abnormal_emotion/affect_behav0.96400166
68MP0008875_abnormal_xenobiotic_pharmacok0.95625336
69MP0003123_paternal_imprinting0.93370099
70MP0005636_abnormal_mineral_homeostasis0.92684950
71MP0003633_abnormal_nervous_system0.92080714
72MP0004742_abnormal_vestibular_system0.91511543
73MP0005448_abnormal_energy_balance0.91390127
74MP0005365_abnormal_bile_salt0.91374856
75MP0001970_abnormal_pain_threshold0.90315492
76MP0000230_abnormal_systemic_arterial0.89380586
77MP0005266_abnormal_metabolism0.89025868
78MP0001440_abnormal_grooming_behavior0.88803443
79MP0002106_abnormal_muscle_physiology0.88271828
80MP0005535_abnormal_body_temperature0.86826002
81MP0001984_abnormal_olfaction0.84985988
82MP0008775_abnormal_heart_ventricle0.83849171
83MP0003953_abnormal_hormone_level0.82962715
84MP0002332_abnormal_exercise_endurance0.82482855
85MP0005167_abnormal_blood-brain_barrier0.82451423
86MP0005389_reproductive_system_phenotype0.82134109
87MP0000427_abnormal_hair_cycle0.80991677
88MP0005174_abnormal_tail_pigmentation0.79503123
89MP0002067_abnormal_sensory_capabilities0.79458957
90MP0005369_muscle_phenotype0.78565634
91MP0004085_abnormal_heartbeat0.76233851
92MP0001919_abnormal_reproductive_system0.76091228
93MP0002138_abnormal_hepatobiliary_system0.75649973
94MP0002184_abnormal_innervation0.75270128
95MP0004510_myositis0.75144193
96MP0003635_abnormal_synaptic_transmissio0.74061094
97MP0002734_abnormal_mechanical_nocicepti0.73977036
98MP0001529_abnormal_vocalization0.73235268
99MP0002118_abnormal_lipid_homeostasis0.72994434
100MP0000516_abnormal_urinary_system0.70932728

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic seizures (HP:0002173)6.84702026
2Hyperinsulinemic hypoglycemia (HP:0000825)6.59722299
3Hypoglycemic coma (HP:0001325)6.13187894
4Ketoacidosis (HP:0001993)5.24174575
5Abnormality of the pancreatic islet cells (HP:0006476)4.76344844
6Abnormality of endocrine pancreas physiology (HP:0012093)4.76344844
7Large for gestational age (HP:0001520)4.45274330
8Symptomatic seizures (HP:0011145)4.45240904
9Hyperglycemia (HP:0003074)4.19576543
10Pancreatic islet-cell hyperplasia (HP:0004510)4.02908825
11Hypothermia (HP:0002045)3.79711786
12Late onset (HP:0003584)3.60120877
13Ketosis (HP:0001946)3.59201226
14Prominent metopic ridge (HP:0005487)3.44747033
15Abnormality of the metopic suture (HP:0005556)3.24464001
16Insulin-resistant diabetes mellitus (HP:0000831)3.17279326
17Molar tooth sign on MRI (HP:0002419)3.06710684
18Abnormality of midbrain morphology (HP:0002418)3.06710684
19Pancreatic cysts (HP:0001737)3.01617043
20Hepatic necrosis (HP:0002605)3.00517618
21Muscle hypertrophy of the lower extremities (HP:0008968)2.99814580
22Calf muscle hypertrophy (HP:0008981)2.95773982
23Hypomagnesemia (HP:0002917)2.93456719
24Abnormality of the renal cortex (HP:0011035)2.92491474
25Nephronophthisis (HP:0000090)2.91169552
26Congenital stationary night blindness (HP:0007642)2.86391048
27Hyperventilation (HP:0002883)2.70131468
28Polydipsia (HP:0001959)2.66778041
29Abnormal drinking behavior (HP:0030082)2.66778041
30Pancreatic fibrosis (HP:0100732)2.64537701
31Abnormality of the renal medulla (HP:0100957)2.56266552
32Hypsarrhythmia (HP:0002521)2.50988583
33EEG with generalized epileptiform discharges (HP:0011198)2.49390789
34Epileptiform EEG discharges (HP:0011182)2.47261989
35Progressive inability to walk (HP:0002505)2.45498692
36Hepatocellular necrosis (HP:0001404)2.38477407
37True hermaphroditism (HP:0010459)2.34993201
38Progressive macrocephaly (HP:0004481)2.30879724
39Hemiparesis (HP:0001269)2.25295976
40Mitochondrial inheritance (HP:0001427)2.25010073
41Muscle fiber inclusion bodies (HP:0100299)2.24908221
42Renal cortical cysts (HP:0000803)2.18545371
43Type I diabetes mellitus (HP:0100651)2.17735210
44Increased CSF lactate (HP:0002490)2.17138336
45Acute necrotizing encephalopathy (HP:0006965)2.11880064
46Nemaline bodies (HP:0003798)2.10994201
47Abnormality of magnesium homeostasis (HP:0004921)2.08378465
48Medial flaring of the eyebrow (HP:0010747)2.08288395
49Tubular atrophy (HP:0000092)2.07471698
50Increased circulating renin level (HP:0000848)2.07296278
51Polyuria (HP:0000103)2.06036008
52Methylmalonic acidemia (HP:0002912)2.04464868
53Attenuation of retinal blood vessels (HP:0007843)2.02623007
54Type II lissencephaly (HP:0007260)2.02150846
55Abnormal rod and cone electroretinograms (HP:0008323)2.00383071
56Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.00133217
57Intestinal atresia (HP:0011100)1.98247342
58Gaze-evoked nystagmus (HP:0000640)1.97568778
59Inability to walk (HP:0002540)1.96039947
60Febrile seizures (HP:0002373)1.93544107
61Muscular hypotonia of the trunk (HP:0008936)1.92887879
62Agitation (HP:0000713)1.92579905
63Tachypnea (HP:0002789)1.91546914
64Abolished electroretinogram (ERG) (HP:0000550)1.89548962
65Downturned corners of mouth (HP:0002714)1.87048224
66Albinism (HP:0001022)1.82935449
67Broad-based gait (HP:0002136)1.81303610
68Aplasia/Hypoplasia of the fovea (HP:0008060)1.80665824
69Hypoplasia of the fovea (HP:0007750)1.80665824
70Abnormal pancreas size (HP:0012094)1.78862921
71Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.78591825
72Methylmalonic aciduria (HP:0012120)1.77658719
73Tongue fasciculations (HP:0001308)1.76133966
74Acute encephalopathy (HP:0006846)1.74912887
75Furrowed tongue (HP:0000221)1.74831562
76Dicarboxylic aciduria (HP:0003215)1.74502469
77Abnormality of dicarboxylic acid metabolism (HP:0010995)1.74502469
78Neoplasm of the adrenal cortex (HP:0100641)1.73607852
79Dialeptic seizures (HP:0011146)1.73286390
80Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.72604980
81Myoglobinuria (HP:0002913)1.71795773
82Exercise-induced muscle cramps (HP:0003710)1.71063857
83Cystic liver disease (HP:0006706)1.66605623
84Abnormal mitochondria in muscle tissue (HP:0008316)1.65652724
85Congenital, generalized hypertrichosis (HP:0004540)1.64792730
86Stomatitis (HP:0010280)1.63681742
87Hamartoma of the eye (HP:0010568)1.63561366
88Abnormal urine output (HP:0012590)1.62839968
89Abnormality of renin-angiotensin system (HP:0000847)1.62152925
90Tetany (HP:0001281)1.62047090
91Abnormality of the pons (HP:0007361)1.61845754
92Frequent falls (HP:0002359)1.61722072
93Severe muscular hypotonia (HP:0006829)1.59962207
94Hematochezia (HP:0002573)1.59919288
95Hypokinesia (HP:0002375)1.59832625
96Abnormality of vitamin B metabolism (HP:0004340)1.59717917
97Enlarged penis (HP:0000040)1.58886931
98Decreased circulating renin level (HP:0003351)1.58625418
99Hypokalemia (HP:0002900)1.58286683
100Disproportionate short-trunk short stature (HP:0003521)1.58092495

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.95830609
2PHKG22.76730111
3PHKG12.76730111
4OBSCN2.69325970
5ADRBK22.59484900
6DAPK22.44919161
7INSRR2.40142294
8PINK12.30830802
9WNK32.26514854
10PASK2.16405724
11GRK12.14871849
12NTRK32.10525957
13TNIK2.05187278
14NUAK12.00457707
15ACVR1B1.99459562
16BMPR1B1.96902018
17MST41.78611996
18FGFR21.77364110
19OXSR11.65317044
20MAP4K21.61621218
21TAOK31.54965202
22CASK1.51264063
23MAPK131.49545759
24PNCK1.42042442
25ZAK1.36223810
26MAP2K61.33634627
27MARK11.31172740
28STK391.25329727
29PAK31.23257725
30PIK3CG1.17252582
31WNK41.13763337
32IRAK11.08082655
33CAMKK21.06335513
34MAPKAPK31.05924967
35NLK1.05109604
36PRKCE1.04188776
37TXK1.04186022
38MAP3K41.00947363
39EIF2AK31.00767049
40CSNK1G10.99019650
41STK30.98409519
42PRKAA20.98329024
43FER0.98192776
44PTK2B0.95594069
45PLK20.89839403
46HIPK20.88497380
47MKNK20.83574863
48PRKCG0.83146210
49CSNK1G30.79091824
50CSNK1G20.76026904
51ADRBK10.75468212
52SGK20.73606463
53TRPM70.72534285
54STK38L0.72193205
55MUSK0.71385186
56PRKAA10.69510199
57ERBB30.68386573
58TRIM280.63361090
59IKBKB0.62591930
60CAMK10.59568816
61PLK30.58640617
62TLK10.57204716
63TNK20.55656798
64MAP3K90.55392613
65PRKACA0.54954755
66CDK30.54713946
67AKT30.53812957
68DYRK20.53038197
69PRKG10.52897111
70TEC0.52837264
71TIE10.51010962
72CHUK0.49210476
73CAMK2A0.48186353
74VRK10.48072732
75TAF10.45487591
76CSNK1A1L0.45337644
77MAP2K70.44983559
78CAMK1G0.44643183
79STK110.44257111
80EPHA30.42739021
81GRK70.40568164
82MAP3K10.39699367
83FGFR30.39116729
84CAMK2D0.38987870
85PKN10.38686357
86PRKCI0.38320483
87CSNK1A10.37895982
88MAP3K20.37380404
89NME10.36578903
90SGK4940.33455317
91SGK2230.33455317
92PRKCA0.31699895
93MAP3K70.30781547
94FES0.29100656
95CSNK1D0.26605020
96ITK0.26523690
97PRKCZ0.24899048
98SGK10.24794723
99TGFBR10.24277120
100STK240.24116181

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049506.47081233
2Butanoate metabolism_Homo sapiens_hsa006503.09727251
3Protein export_Homo sapiens_hsa030602.98775558
4Insulin secretion_Homo sapiens_hsa049112.68870391
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.25565335
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.20779678
7Type II diabetes mellitus_Homo sapiens_hsa049302.16927681
8Phototransduction_Homo sapiens_hsa047442.16846194
9Tryptophan metabolism_Homo sapiens_hsa003802.13821280
10Oxidative phosphorylation_Homo sapiens_hsa001902.08741295
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.97839430
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.88709653
13Regulation of autophagy_Homo sapiens_hsa041401.83884166
14Sulfur metabolism_Homo sapiens_hsa009201.78686711
15Selenocompound metabolism_Homo sapiens_hsa004501.76950327
16Collecting duct acid secretion_Homo sapiens_hsa049661.69184096
17Type I diabetes mellitus_Homo sapiens_hsa049401.66516785
18Propanoate metabolism_Homo sapiens_hsa006401.61535802
19Nitrogen metabolism_Homo sapiens_hsa009101.53166649
20Linoleic acid metabolism_Homo sapiens_hsa005911.47427710
21Fatty acid elongation_Homo sapiens_hsa000621.46085714
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.44391278
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.39419450
24Cardiac muscle contraction_Homo sapiens_hsa042601.37791498
25Fatty acid degradation_Homo sapiens_hsa000711.36892432
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.32552472
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.29732057
28Parkinsons disease_Homo sapiens_hsa050121.23824022
29Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.22690810
30Ether lipid metabolism_Homo sapiens_hsa005651.20143292
31ABC transporters_Homo sapiens_hsa020101.20111992
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19744828
33Circadian rhythm_Homo sapiens_hsa047101.13580713
34Peroxisome_Homo sapiens_hsa041461.11656843
35Ovarian steroidogenesis_Homo sapiens_hsa049131.11159751
36Fatty acid metabolism_Homo sapiens_hsa012121.11149391
37beta-Alanine metabolism_Homo sapiens_hsa004101.05191021
38Nicotine addiction_Homo sapiens_hsa050331.04384208
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.97573640
40Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.97524853
41Taste transduction_Homo sapiens_hsa047420.96673731
42Alzheimers disease_Homo sapiens_hsa050100.94403929
43Basal transcription factors_Homo sapiens_hsa030220.94092225
44Circadian entrainment_Homo sapiens_hsa047130.83987221
45Caffeine metabolism_Homo sapiens_hsa002320.83756572
46Mineral absorption_Homo sapiens_hsa049780.83459444
47Dorso-ventral axis formation_Homo sapiens_hsa043200.81175237
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81162166
49Renin secretion_Homo sapiens_hsa049240.80757616
50Synaptic vesicle cycle_Homo sapiens_hsa047210.79565972
51Olfactory transduction_Homo sapiens_hsa047400.74868602
52One carbon pool by folate_Homo sapiens_hsa006700.73800817
53Amphetamine addiction_Homo sapiens_hsa050310.70696494
54Salivary secretion_Homo sapiens_hsa049700.69988158
55Primary bile acid biosynthesis_Homo sapiens_hsa001200.68443506
56RNA polymerase_Homo sapiens_hsa030200.67515130
57Serotonergic synapse_Homo sapiens_hsa047260.66291234
58Calcium signaling pathway_Homo sapiens_hsa040200.66079045
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.65784155
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65057000
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64332562
62Morphine addiction_Homo sapiens_hsa050320.64316911
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63425000
64Homologous recombination_Homo sapiens_hsa034400.63248023
65Cocaine addiction_Homo sapiens_hsa050300.63118722
66Glutamatergic synapse_Homo sapiens_hsa047240.62342666
67Glucagon signaling pathway_Homo sapiens_hsa049220.61173430
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59076982
69Chemical carcinogenesis_Homo sapiens_hsa052040.58896007
70Huntingtons disease_Homo sapiens_hsa050160.58881216
71GABAergic synapse_Homo sapiens_hsa047270.58298490
72Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.56476561
73Glycerolipid metabolism_Homo sapiens_hsa005610.55795925
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55123870
75RNA degradation_Homo sapiens_hsa030180.52816770
76Rheumatoid arthritis_Homo sapiens_hsa053230.52228010
77Arachidonic acid metabolism_Homo sapiens_hsa005900.51569554
78Lysine degradation_Homo sapiens_hsa003100.49921286
79Retinol metabolism_Homo sapiens_hsa008300.49920638
80Sphingolipid metabolism_Homo sapiens_hsa006000.48357302
81Dopaminergic synapse_Homo sapiens_hsa047280.48023538
82Starch and sucrose metabolism_Homo sapiens_hsa005000.47831788
83Long-term depression_Homo sapiens_hsa047300.46988480
84Insulin resistance_Homo sapiens_hsa049310.46706840
85Metabolic pathways_Homo sapiens_hsa011000.46606768
86Pancreatic secretion_Homo sapiens_hsa049720.45786425
87Histidine metabolism_Homo sapiens_hsa003400.44727252
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.44693129
89Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.44623760
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43922419
91Oxytocin signaling pathway_Homo sapiens_hsa049210.43909501
92Aldosterone synthesis and secretion_Homo sapiens_hsa049250.43604317
93Proteasome_Homo sapiens_hsa030500.43112717
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41803002
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.41673196
96Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.40017831
97Thyroid hormone synthesis_Homo sapiens_hsa049180.39331746
98Fanconi anemia pathway_Homo sapiens_hsa034600.39185165
99Purine metabolism_Homo sapiens_hsa002300.37981879
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.37015909

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