C1ORF106

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)6.86544433
2regulation of guanylate cyclase activity (GO:0031282)6.69022692
3bundle of His cell to Purkinje myocyte communication (GO:0086069)6.41358281
4angiotensin maturation (GO:0002003)6.28392270
5calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)6.04954956
6intestinal absorption (GO:0050892)5.92745412
7regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.27974956
8positive regulation of guanylate cyclase activity (GO:0031284)5.23887854
9vitamin transmembrane transport (GO:0035461)4.69028679
10glucuronate metabolic process (GO:0019585)4.48700912
11uronic acid metabolic process (GO:0006063)4.48700912
12epoxygenase P450 pathway (GO:0019373)4.39742242
13multicellular organismal water homeostasis (GO:0050891)4.38814824
14cellular glucuronidation (GO:0052695)4.38641954
15regulation of bile acid biosynthetic process (GO:0070857)4.31126798
16establishment of skin barrier (GO:0061436)4.29440302
17regulation of water loss via skin (GO:0033561)4.27968916
18digestion (GO:0007586)4.20350104
19hemidesmosome assembly (GO:0031581)4.18112131
20intestinal epithelial cell development (GO:0060576)4.07278207
21negative regulation of keratinocyte proliferation (GO:0010839)3.98440117
22regulation of systemic arterial blood pressure by hormone (GO:0001990)3.95049562
23regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.95049562
24endocrine process (GO:0050886)3.95049562
25regulation of cGMP biosynthetic process (GO:0030826)3.91165638
26renal system process involved in regulation of blood volume (GO:0001977)3.89385052
27fat-soluble vitamin biosynthetic process (GO:0042362)3.86607034
28drug metabolic process (GO:0017144)3.86392090
29receptor guanylyl cyclase signaling pathway (GO:0007168)3.85266356
30regulation of keratinocyte proliferation (GO:0010837)3.83171118
31maintenance of gastrointestinal epithelium (GO:0030277)3.80763078
32primary alcohol catabolic process (GO:0034310)3.79142437
33O-glycan processing (GO:0016266)3.77628913
34flavonoid metabolic process (GO:0009812)3.75424366
35NADH metabolic process (GO:0006734)3.75338964
36negative regulation of epidermis development (GO:0045683)3.75112875
37regulation of systemic arterial blood pressure (GO:0003073)3.72125958
38negative regulation of epidermal cell differentiation (GO:0045605)3.71199371
39auditory receptor cell differentiation (GO:0042491)3.68491976
40positive regulation of pseudopodium assembly (GO:0031274)3.67049307
41phosphatidylserine acyl-chain remodeling (GO:0036150)3.59040666
42bile acid and bile salt transport (GO:0015721)3.55092136
43water homeostasis (GO:0030104)3.52896973
44positive regulation of respiratory burst (GO:0060267)3.45035982
45vitamin transport (GO:0051180)3.41495619
46tight junction assembly (GO:0070830)3.41156037
47positive regulation of glycoprotein biosynthetic process (GO:0010560)3.40773787
48excretion (GO:0007588)3.40077489
49phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.40050380
50homocysteine metabolic process (GO:0050667)3.38902154
51regulation of cGMP metabolic process (GO:0030823)3.38593466
52regulation of cholesterol homeostasis (GO:2000188)3.37670218
53antibacterial humoral response (GO:0019731)3.29743546
54keratinocyte proliferation (GO:0043616)3.28435291
55sulfate transmembrane transport (GO:1902358)3.27902742
56ethanol oxidation (GO:0006069)3.26516681
57GDP-mannose metabolic process (GO:0019673)3.26272856
58antimicrobial humoral response (GO:0019730)3.24558904
59sulfur compound transport (GO:0072348)3.22160370
60ethanol metabolic process (GO:0006067)3.19382309
61cobalamin metabolic process (GO:0009235)3.18850079
62transepithelial transport (GO:0070633)3.18713431
63transcytosis (GO:0045056)3.17470679
64fucosylation (GO:0036065)3.17310748
65regulation of pseudopodium assembly (GO:0031272)3.14807057
66drug catabolic process (GO:0042737)3.14529381
67exogenous drug catabolic process (GO:0042738)3.14155362
68arginine metabolic process (GO:0006525)3.13112772
69regulation of cellular extravasation (GO:0002691)3.13084745
70digestive system process (GO:0022600)3.10997026
71oligosaccharide biosynthetic process (GO:0009312)3.09345344
72hormone catabolic process (GO:0042447)3.08969852
73gap junction assembly (GO:0016264)3.07301702
74nucleotide-sugar biosynthetic process (GO:0009226)3.04306302
75L-fucose catabolic process (GO:0042355)3.04270317
76fucose catabolic process (GO:0019317)3.04270317
77L-fucose metabolic process (GO:0042354)3.04270317
78positive regulation of glycoprotein metabolic process (GO:1903020)3.01847533
79epithelial cell-cell adhesion (GO:0090136)3.01781717
80sphingomyelin metabolic process (GO:0006684)3.00572135
81renal filtration (GO:0097205)2.96955692
82glutathione biosynthetic process (GO:0006750)2.96692944
83nonribosomal peptide biosynthetic process (GO:0019184)2.90119496
84positive regulation of cGMP biosynthetic process (GO:0030828)2.87035623
85kidney morphogenesis (GO:0060993)2.84900786
86diacylglycerol metabolic process (GO:0046339)2.84205982
87epithelial structure maintenance (GO:0010669)2.83096017
88lipoprotein transport (GO:0042953)2.81902709
89glomerular filtration (GO:0003094)2.81169228
90keratinization (GO:0031424)2.80977548
91renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.80524891
92drug transmembrane transport (GO:0006855)2.77395031
93urea cycle (GO:0000050)2.76752857
94regulation of keratinocyte differentiation (GO:0045616)2.75350342
95drug transport (GO:0015893)2.75084021
96primary alcohol metabolic process (GO:0034308)2.74910424
97regulation of vitamin metabolic process (GO:0030656)2.74704866
98sodium ion homeostasis (GO:0055078)2.74645627
99positive regulation of Cdc42 GTPase activity (GO:0043089)2.74216218
100sulfate transport (GO:0008272)2.73401466

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.61672876
2* CDX2_20551321_ChIP-Seq_CACO-2_Human4.89585958
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.03146706
4SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.35271855
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.27956015
6GATA4_25053715_ChIP-Seq_YYC3_Human3.25705871
7SOX2_27498859_Chip-Seq_STOMACH_Mouse3.12482673
8* GATA6_25053715_ChIP-Seq_YYC3_Human3.02258036
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.88062086
10HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.59614011
11SOX2_20726797_ChIP-Seq_SW620_Human2.56718986
12FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.42959397
13FOXO3_23340844_ChIP-Seq_DLD1_Human2.27176262
14* P63_26484246_Chip-Seq_KERATINOCYTES_Human2.18550780
15ESR2_21235772_ChIP-Seq_MCF-7_Human2.08590548
16CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.06253104
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.97924850
18PPARA_22158963_ChIP-Seq_LIVER_Mouse1.89323229
19* KLF5_25053715_ChIP-Seq_YYC3_Human1.88622845
20* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.88616895
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.83885889
22ZNF263_19887448_ChIP-Seq_K562_Human1.78355042
23* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.75864312
24PPAR_26484153_Chip-Seq_NCI-H1993_Human1.72174191
25NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.71308672
26EGR1_23403033_ChIP-Seq_LIVER_Mouse1.69266325
27* RUNX1_27514584_Chip-Seq_MCF-7_Human1.69091778
28* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.68427660
29ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.67805102
30RACK7_27058665_Chip-Seq_MCF-7_Human1.64873907
31RXR_22158963_ChIP-Seq_LIVER_Mouse1.63972223
32TCF3_18692474_ChIP-Seq_MEFs_Mouse1.63359394
33BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.60147095
34AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.55393914
35LXR_22158963_ChIP-Seq_LIVER_Mouse1.54301374
36AR_21909140_ChIP-Seq_LNCAP_Human1.53367870
37FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.52038128
38* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.48865364
39* GATA3_24758297_ChIP-Seq_MCF-7_Human1.47004002
40NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.45426942
41POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.37681366
42FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.35788284
43* TCF4_18268006_ChIP-ChIP_LS174T_Human1.35462164
44FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.35369238
45* TP63_22573176_ChIP-Seq_HFKS_Human1.33900303
46CTCF_27219007_Chip-Seq_Bcells_Human1.33633639
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.27611477
48PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.26086439
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.22176601
50TRIM28_21343339_ChIP-Seq_HEK293_Human1.20751422
51FOXA1_25552417_ChIP-Seq_VCAP_Human1.19115044
52TCF3_18692474_ChIP-Seq_MESCs_Mouse1.19088206
53IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.17164741
54CDX2_22108803_ChIP-Seq_LS180_Human1.16371376
55SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.15770974
56SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.15770974
57ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14148129
58KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.13852192
59TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12900932
60SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.12771452
61* SA1_27219007_Chip-Seq_Bcells_Human1.11631923
62PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.11316066
63NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.10503156
64* HNF4A_19822575_ChIP-Seq_HepG2_Human1.10416881
65LXR_22292898_ChIP-Seq_THP-1_Human1.08818404
66NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.07720745
67ATF3_27146783_Chip-Seq_COLON_Human1.06875225
68* TP63_23658742_ChIP-Seq_EP156T_Human1.04662861
69* NANOG_20526341_ChIP-Seq_ESCs_Human1.03184817
70SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.03082334
71CEBPB_22108803_ChIP-Seq_LS180_Human1.02972083
72SOX9_24532713_ChIP-Seq_HFSC_Mouse1.02967574
73RXR_22108803_ChIP-Seq_LS180_Human0.99965506
74PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.99592801
75HIF1A_21447827_ChIP-Seq_MCF-7_Human0.99397121
76FOXA2_19822575_ChIP-Seq_HepG2_Human0.98342676
77SRY_22984422_ChIP-ChIP_TESTIS_Rat0.96900936
78BCOR_27268052_Chip-Seq_Bcells_Human0.95358441
79VDR_22108803_ChIP-Seq_LS180_Human0.94802975
80AHR_22903824_ChIP-Seq_MCF-7_Human0.94214903
81NANOG_18692474_ChIP-Seq_MEFs_Mouse0.92826558
82ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91913762
83STAT6_21828071_ChIP-Seq_BEAS2B_Human0.91293943
84NANOG_18692474_ChIP-Seq_MESCs_Mouse0.89700502
85PHF8_20622854_ChIP-Seq_HELA_Human0.89213030
86CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.88679659
87* E2F1_20622854_ChIP-Seq_HELA_Human0.88589311
88CREB1_26743006_Chip-Seq_LNCaP_Human0.87479707
89* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.87184132
90RARG_19884340_ChIP-ChIP_MEFs_Mouse0.86975588
91P53_21459846_ChIP-Seq_SAOS-2_Human0.85979526
92P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.84627065
93TET1_21451524_ChIP-Seq_MESCs_Mouse0.83544569
94SMAD3_21741376_ChIP-Seq_HESCs_Human0.83139338
95BCL6_27268052_Chip-Seq_Bcells_Human0.81672302
96SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.80503642
97PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.80283560
98CTCF_20526341_ChIP-Seq_ESCs_Human0.80230124
99YY1_22570637_ChIP-Seq_MALME-3M_Human0.79712143
100NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.78874262

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.87626525
2MP0005360_urolithiasis4.86831687
3MP0000566_synostosis3.93232422
4MP0004264_abnormal_extraembryonic_tissu3.92012560
5MP0009379_abnormal_foot_pigmentation3.61779486
6MP0002139_abnormal_hepatobiliary_system3.51141764
7MP0002796_impaired_skin_barrier3.49878222
8MP0001666_abnormal_nutrient_absorption3.31133165
9MP0005085_abnormal_gallbladder_physiolo3.05695560
10MP0004019_abnormal_vitamin_homeostasis2.72704367
11MP0002098_abnormal_vibrissa_morphology2.55419310
12MP0005365_abnormal_bile_salt2.49023126
13MP0000579_abnormal_nail_morphology2.46482038
14MP0010678_abnormal_skin_adnexa2.38355308
15MP0010352_gastrointestinal_tract_polyps2.28828193
16MP0005501_abnormal_skin_physiology2.18973489
17MP0004043_abnormal_pH_regulation2.18537684
18MP0003941_abnormal_skin_development2.11685404
19MP0000537_abnormal_urethra_morphology2.09349169
20MP0003183_abnormal_peptide_metabolism1.98035516
21MP0001664_abnormal_digestion1.94501336
22MP0000490_abnormal_crypts_of1.81890094
23MP0000467_abnormal_esophagus_morphology1.80194688
24MP0004782_abnormal_surfactant_physiolog1.78079898
25MP0000383_abnormal_hair_follicle1.76747986
26MP0010155_abnormal_intestine_physiology1.71594091
27MP0003693_abnormal_embryo_hatching1.71077801
28MP0009840_abnormal_foam_cell1.70491486
29MP0000477_abnormal_intestine_morphology1.69083354
30MP0000678_abnormal_parathyroid_gland1.62981430
31MP0001216_abnormal_epidermal_layer1.59747044
32MP0005409_darkened_coat_color1.50960622
33MP0003866_abnormal_defecation1.49013845
34MP0008875_abnormal_xenobiotic_pharmacok1.47821594
35MP0004147_increased_porphyrin_level1.44671985
36MP0001188_hyperpigmentation1.42729405
37MP0009643_abnormal_urine_homeostasis1.41020746
38MP0003453_abnormal_keratinocyte_physiol1.37085121
39MP0001765_abnormal_ion_homeostasis1.35425525
40MP0000762_abnormal_tongue_morphology1.34237524
41MP0002876_abnormal_thyroid_physiology1.32187064
42MP0000462_abnormal_digestive_system1.30345297
43MP0001873_stomach_inflammation1.27706142
44MP0005332_abnormal_amino_acid1.27386119
45MP0003718_maternal_effect1.26458683
46MP0005670_abnormal_white_adipose1.26246139
47MP0001485_abnormal_pinna_reflex1.26127032
48MP0010329_abnormal_lipoprotein_level1.23890006
49MP0002138_abnormal_hepatobiliary_system1.19427058
50MP0008872_abnormal_physiological_respon1.19085605
51MP0001849_ear_inflammation1.18807944
52MP0000377_abnormal_hair_follicle1.17965092
53MP0003119_abnormal_digestive_system1.12564913
54MP0000538_abnormal_urinary_bladder1.12041274
55MP0010771_integument_phenotype1.08592665
56MP0003878_abnormal_ear_physiology1.07133831
57MP0005377_hearing/vestibular/ear_phenot1.07133831
58MP0002254_reproductive_system_inflammat1.06463351
59MP0002136_abnormal_kidney_physiology1.04766081
60MP0000427_abnormal_hair_cycle1.01934565
61MP0001663_abnormal_digestive_system1.00532779
62MP0005381_digestive/alimentary_phenotyp1.00341337
63MP0004858_abnormal_nervous_system0.98249076
64MP0003252_abnormal_bile_duct0.96316416
65MP0004957_abnormal_blastocyst_morpholog0.96159632
66MP0003315_abnormal_perineum_morphology0.95964983
67MP0005636_abnormal_mineral_homeostasis0.95495027
68MP0001756_abnormal_urination0.93474362
69MP0002089_abnormal_postnatal_growth/wei0.90516438
70MP0000470_abnormal_stomach_morphology0.88971973
71MP0010030_abnormal_orbit_morphology0.82172854
72MP0003868_abnormal_feces_composition0.78926237
73MP0002111_abnormal_tail_morphology0.78794038
74MP0003937_abnormal_limbs/digits/tail_de0.77934501
75MP0005083_abnormal_biliary_tract0.77578662
76MP0002233_abnormal_nose_morphology0.77129542
77MP0005367_renal/urinary_system_phenotyp0.76953572
78MP0000516_abnormal_urinary_system0.76953572
79MP0008789_abnormal_olfactory_epithelium0.76605892
80MP0003938_abnormal_ear_development0.70879719
81MP0002060_abnormal_skin_morphology0.69042992
82MP0002249_abnormal_larynx_morphology0.68926410
83MP0005023_abnormal_wound_healing0.68343800
84MP0001764_abnormal_homeostasis0.66413317
85MP0000647_abnormal_sebaceous_gland0.65985419
86MP0005166_decreased_susceptibility_to0.63667207
87MP0000627_abnormal_mammary_gland0.63423833
88MP0003638_abnormal_response/metabolism_0.62697369
89MP0004133_heterotaxia0.60787827
90MP0009053_abnormal_anal_canal0.58902841
91MP0002234_abnormal_pharynx_morphology0.58643500
92MP0001881_abnormal_mammary_gland0.57381715
93MP0003283_abnormal_digestive_organ0.56818472
94MP0002118_abnormal_lipid_homeostasis0.56804265
95MP0009931_abnormal_skin_appearance0.55095857
96MP0000367_abnormal_coat/_hair0.52800278
97MP0003755_abnormal_palate_morphology0.51529891
98MP0005394_taste/olfaction_phenotype0.51408761
99MP0005499_abnormal_olfactory_system0.51408761
100MP0001286_abnormal_eye_development0.50605598

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glutamine family amino acid metabolism (HP:0010902)6.24172083
2Hyperactive renin-angiotensin system (HP:0000841)5.30335317
3Right ventricular cardiomyopathy (HP:0011663)4.89963776
4Hydroxyprolinuria (HP:0003080)4.70965856
5Abnormality of proline metabolism (HP:0010907)4.70965856
6Malnutrition (HP:0004395)4.54509716
7Pili torti (HP:0003777)4.46485690
8Decreased circulating renin level (HP:0003351)4.24375890
9Abnormality of renin-angiotensin system (HP:0000847)3.68583487
10Chronic bronchitis (HP:0004469)3.64841782
11Plantar hyperkeratosis (HP:0007556)3.62425591
12Abnormal hair laboratory examination (HP:0003328)3.56018153
13Hyperglycinuria (HP:0003108)3.32771907
14Fragile nails (HP:0001808)3.29532778
15Abnormality of the vitamin B12 metabolism (HP:0004341)3.27563026
16Palmoplantar hyperkeratosis (HP:0000972)3.07607303
17Woolly hair (HP:0002224)3.07403182
18Abnormality of vitamin B metabolism (HP:0004340)3.06975358
19Ileus (HP:0002595)3.06823582
20Metabolic alkalosis (HP:0200114)3.01712145
21Confusion (HP:0001289)2.97844525
22Abnormality of chloride homeostasis (HP:0011422)2.94975162
23Palmar hyperkeratosis (HP:0010765)2.92027340
24Alkalosis (HP:0001948)2.89598750
25Focal segmental glomerulosclerosis (HP:0000097)2.87368230
26Abnormality of serine family amino acid metabolism (HP:0010894)2.86704031
27Abnormality of glycine metabolism (HP:0010895)2.86704031
28Milia (HP:0001056)2.82537727
29Widely patent fontanelles and sutures (HP:0004492)2.82523372
30Alopecia of scalp (HP:0002293)2.76010393
31Flat acetabular roof (HP:0003180)2.75825007
32Fat malabsorption (HP:0002630)2.68553923
33Increased purine levels (HP:0004368)2.68382974
34Hyperuricemia (HP:0002149)2.68382974
35Abnormality of vitamin metabolism (HP:0100508)2.67875580
36Hyperaldosteronism (HP:0000859)2.67377095
37Onycholysis (HP:0001806)2.62930927
38Abnormality of nail color (HP:0100643)2.58019808
39Abnormality of monocarboxylic acid metabolism (HP:0010996)2.52093433
40Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.49100705
41Chronic diarrhea (HP:0002028)2.46883892
42Glomerulosclerosis (HP:0000096)2.45613029
43Gout (HP:0001997)2.41855564
44Dehydration (HP:0001944)2.41281072
45Hypobetalipoproteinemia (HP:0003563)2.37631169
46Hypotrichosis (HP:0001006)2.37526073
47Abdominal distention (HP:0003270)2.36510782
48Glycosuria (HP:0003076)2.35494825
49Abnormality of urine glucose concentration (HP:0011016)2.35494825
50Amelogenesis imperfecta (HP:0000705)2.31181192
51Pterygium (HP:0001059)2.27099407
52Congenital sensorineural hearing impairment (HP:0008527)2.23996847
53Abnormal tarsal ossification (HP:0008369)2.17702856
54Hyperkalemia (HP:0002153)2.17326550
55Abnormal pancreas size (HP:0012094)2.12510591
56Delayed epiphyseal ossification (HP:0002663)2.12354851
57Abnormality of small intestinal villus morphology (HP:0011472)2.12070389
58Villous atrophy (HP:0011473)2.12070389
59Pigmentary retinal degeneration (HP:0001146)2.11154646
60Abnormal biliary tract morphology (HP:0012440)2.10294352
61Bronchomalacia (HP:0002780)2.08998981
62Hyponatremia (HP:0002902)2.06578008
63Curly hair (HP:0002212)2.03895889
64Bronchiectasis (HP:0002110)2.03183774
65Hypoplasia of the uterus (HP:0000013)2.02722022
66Sparse eyelashes (HP:0000653)1.99799973
67Popliteal pterygium (HP:0009756)1.98410155
68Renal salt wasting (HP:0000127)1.96929662
69Hypoplastic labia majora (HP:0000059)1.96459086
70Abnormality of purine metabolism (HP:0004352)1.95113925
71Abnormality of the gastric mucosa (HP:0004295)1.94315863
72Flattened epiphyses (HP:0003071)1.93826874
73Tubular atrophy (HP:0000092)1.93611461
74Intrahepatic cholestasis (HP:0001406)1.92280503
75Late onset (HP:0003584)1.90215219
76Nephrolithiasis (HP:0000787)1.88454084
77Rhinitis (HP:0012384)1.86705272
78Acanthocytosis (HP:0001927)1.86615603
79Abnormality of the salivary glands (HP:0010286)1.85008885
80Wide cranial sutures (HP:0010537)1.84224221
81Proximal tubulopathy (HP:0000114)1.81887284
82Congenital ichthyosiform erythroderma (HP:0007431)1.81673982
83Abnormality of nucleobase metabolism (HP:0010932)1.81191333
84Hypoplasia of dental enamel (HP:0006297)1.81068696
85Abnormal respiratory motile cilium physiology (HP:0012261)1.79878615
86Abnormality of magnesium homeostasis (HP:0004921)1.79807786
87Abnormal respiratory epithelium morphology (HP:0012253)1.78640726
88Abnormal respiratory motile cilium morphology (HP:0005938)1.78640726
89Abnormality of potassium homeostasis (HP:0011042)1.76895854
90Megaloblastic anemia (HP:0001889)1.76330603
91Biliary tract neoplasm (HP:0100574)1.76097856
92Facial shape deformation (HP:0011334)1.75997277
93Potter facies (HP:0002009)1.75997277
94Abnormality of aspartate family amino acid metabolism (HP:0010899)1.74664139
95Abnormality of the dental root (HP:0006486)1.74300885
96Taurodontia (HP:0000679)1.74300885
97Abnormality of permanent molar morphology (HP:0011071)1.74300885
98Steatorrhea (HP:0002570)1.74277157
99Ridged nail (HP:0001807)1.73657978
100Conjugated hyperbilirubinemia (HP:0002908)1.72370450

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA27.60726352
2MST1R6.80035063
3ACVR1B3.94900878
4LMTK23.62766763
5MET3.11414246
6STK242.63987067
7MST42.53301413
8EPHB22.51486162
9STK392.41681269
10MAP3K102.34408668
11RIPK12.15516737
12OXSR11.97214090
13ERN11.87213787
14PRKG21.85608099
15NME11.77201795
16TNIK1.65197358
17PIK3CA1.43982844
18SMG11.43310569
19STK38L1.38992202
20PTK61.38944921
21MAPK151.31310464
22FER1.22426298
23MAP3K21.13364296
24GRK11.11860190
25TTK1.07374566
26FGFR41.05269764
27PAK41.01207234
28WNK40.99178491
29MAP2K20.98871160
30PRKCI0.98521271
31MAPKAPK30.97944770
32ERBB20.97121528
33PTK20.93034419
34MAP3K120.88679381
35FRK0.85569881
36NEK10.81885327
37MATK0.79626130
38STK30.79434436
39LATS10.79195074
40EEF2K0.78872538
41EPHA40.77503638
42BCR0.77428219
43MKNK20.74537048
44RPS6KB20.73948324
45NLK0.73718682
46SIK10.71025418
47ZAK0.70264662
48TGFBR10.68671707
49TLK10.68026965
50CDK190.63568092
51VRK20.61172034
52FGFR10.60893582
53BMPR1B0.60227835
54MKNK10.59994754
55CASK0.59536013
56PBK0.58518353
57BMX0.58165159
58MAP2K60.56342525
59TRIM280.52511774
60ADRBK20.50002579
61DDR20.47065571
62EPHB10.47012195
63MELK0.43923281
64BRSK20.43804717
65CSNK1A10.39678665
66INSRR0.38910783
67PRKAA20.38511708
68NUAK10.36856431
69NEK20.36790200
70MAP3K90.36755250
71FGFR20.35923077
72IRAK10.33854638
73WNK30.33233778
74PRKCZ0.31944030
75PRKCE0.28153914
76PRKCA0.27943556
77FGFR30.27001286
78CDC42BPA0.26810445
79PDK20.26313765
80PRKCD0.23427173
81SRC0.23220593
82AURKB0.22837642
83CDK80.22589904
84TAF10.22577504
85CHUK0.21561466
86PLK10.21014979
87IGF1R0.20448158
88PASK0.19166069
89PLK40.19115309
90MAPKAPK50.18025696
91MAP3K30.17384166
92CDK90.16523572
93PRKCQ0.15153227
94MAP3K70.14393149
95CSNK1E0.13501180
96MAPK110.13141665
97MAP2K10.12635592
98DYRK20.11928900
99FLT30.09694989
100MAP3K80.09474607

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004605.00674202
2Fat digestion and absorption_Homo sapiens_hsa049753.98621240
3Vitamin digestion and absorption_Homo sapiens_hsa049773.49343413
4Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.93449674
5Renin-angiotensin system_Homo sapiens_hsa046142.76992890
6Histidine metabolism_Homo sapiens_hsa003402.68610622
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.61073728
8Sulfur metabolism_Homo sapiens_hsa009202.55759207
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.52364315
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.38264738
11Linoleic acid metabolism_Homo sapiens_hsa005912.38078210
12Arginine biosynthesis_Homo sapiens_hsa002202.19562549
13Mineral absorption_Homo sapiens_hsa049782.19148640
14Retinol metabolism_Homo sapiens_hsa008302.14862117
15Protein digestion and absorption_Homo sapiens_hsa049742.12262719
16Maturity onset diabetes of the young_Homo sapiens_hsa049502.07446553
17Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.06936138
18Starch and sucrose metabolism_Homo sapiens_hsa005002.00968851
19Chemical carcinogenesis_Homo sapiens_hsa052041.99622043
20Caffeine metabolism_Homo sapiens_hsa002321.98822958
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.94578253
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.89522855
23Fructose and mannose metabolism_Homo sapiens_hsa000511.88693376
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.64791372
25Arginine and proline metabolism_Homo sapiens_hsa003301.64779689
26Galactose metabolism_Homo sapiens_hsa000521.62405488
27Arachidonic acid metabolism_Homo sapiens_hsa005901.56043408
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.52779634
29Glycerolipid metabolism_Homo sapiens_hsa005611.50974947
30Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.50237530
31Ether lipid metabolism_Homo sapiens_hsa005651.49618015
32Bile secretion_Homo sapiens_hsa049761.43679258
33Nitrogen metabolism_Homo sapiens_hsa009101.37985886
34Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.33195258
35Fatty acid degradation_Homo sapiens_hsa000711.31390528
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.24769203
37Tryptophan metabolism_Homo sapiens_hsa003801.19299382
38Glutathione metabolism_Homo sapiens_hsa004801.18147451
39Tight junction_Homo sapiens_hsa045301.17795720
40PPAR signaling pathway_Homo sapiens_hsa033201.16799884
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.11540432
42Sphingolipid metabolism_Homo sapiens_hsa006001.10797449
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.10178838
44Phenylalanine metabolism_Homo sapiens_hsa003601.09577913
45Pancreatic secretion_Homo sapiens_hsa049721.09476277
46Sulfur relay system_Homo sapiens_hsa041221.08073879
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.05159090
48Carbohydrate digestion and absorption_Homo sapiens_hsa049731.04093668
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.02647795
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.00008896
51Glycerophospholipid metabolism_Homo sapiens_hsa005640.85483230
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68296385
53Tyrosine metabolism_Homo sapiens_hsa003500.62570871
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61688758
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60309750
56Peroxisome_Homo sapiens_hsa041460.58143718
57Selenocompound metabolism_Homo sapiens_hsa004500.56829379
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56799731
59Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.56746764
60Butanoate metabolism_Homo sapiens_hsa006500.55368780
61Metabolic pathways_Homo sapiens_hsa011000.52199130
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.51316107
63Pyruvate metabolism_Homo sapiens_hsa006200.51171393
64Fatty acid metabolism_Homo sapiens_hsa012120.49560272
65Basal cell carcinoma_Homo sapiens_hsa052170.48285420
66beta-Alanine metabolism_Homo sapiens_hsa004100.48168284
67Biosynthesis of amino acids_Homo sapiens_hsa012300.46792350
68ABC transporters_Homo sapiens_hsa020100.41827340
69Vitamin B6 metabolism_Homo sapiens_hsa007500.41620819
70Fatty acid biosynthesis_Homo sapiens_hsa000610.39922636
71Hepatitis C_Homo sapiens_hsa051600.38933508
72Propanoate metabolism_Homo sapiens_hsa006400.37864073
73Thyroid hormone synthesis_Homo sapiens_hsa049180.36468776
74Adherens junction_Homo sapiens_hsa045200.34680806
75Steroid biosynthesis_Homo sapiens_hsa001000.33014402
76Asthma_Homo sapiens_hsa053100.30060467
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.28839794
78Hippo signaling pathway_Homo sapiens_hsa043900.28164508
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.27402233
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.26071719
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.25059930
82Phototransduction_Homo sapiens_hsa047440.24696383
83Carbon metabolism_Homo sapiens_hsa012000.22784072
84Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.21874344
85N-Glycan biosynthesis_Homo sapiens_hsa005100.18673899
86Pentose phosphate pathway_Homo sapiens_hsa000300.15735197
87Folate biosynthesis_Homo sapiens_hsa007900.15145689
88Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.14829795
89Fatty acid elongation_Homo sapiens_hsa000620.14359980
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.14024786
91Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.11454906
92Hedgehog signaling pathway_Homo sapiens_hsa043400.11425604
93Notch signaling pathway_Homo sapiens_hsa043300.08889782
94Ovarian steroidogenesis_Homo sapiens_hsa049130.08460196
95Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.06491237
96Insulin resistance_Homo sapiens_hsa049310.06472133
97Primary bile acid biosynthesis_Homo sapiens_hsa001200.06232090
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.03796156
99Glucagon signaling pathway_Homo sapiens_hsa049220.02312769
100Thyroid cancer_Homo sapiens_hsa052160.01401818

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