C1ORF105

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-mediated cell contraction (GO:0070252)9.35280472
2skeletal muscle contraction (GO:0003009)8.71418372
3negative regulation of potassium ion transmembrane transporter activity (GO:1901017)8.33624915
4synapsis (GO:0007129)7.49752250
5negative regulation of potassium ion transmembrane transport (GO:1901380)7.46624654
6plasma membrane fusion (GO:0045026)6.93066107
7actin filament-based movement (GO:0030048)6.88284748
8musculoskeletal movement (GO:0050881)6.77688784
9multicellular organismal movement (GO:0050879)6.77688784
10male meiosis I (GO:0007141)6.70194740
11myoblast fusion (GO:0007520)6.27753609
12striated muscle contraction (GO:0006941)6.27417832
13response to inactivity (GO:0014854)6.09236693
14positive regulation of myoblast differentiation (GO:0045663)5.99963334
15regulation of sarcomere organization (GO:0060297)5.98385635
16positive regulation of myotube differentiation (GO:0010831)5.73013696
17chromosome organization involved in meiosis (GO:0070192)5.70432299
18meiosis I (GO:0007127)5.54920862
19syncytium formation by plasma membrane fusion (GO:0000768)5.38402227
20striated muscle atrophy (GO:0014891)5.38114067
21regulation of skeletal muscle contraction (GO:0014819)5.35976291
22muscle cell fate commitment (GO:0042693)5.10464616
23response to stimulus involved in regulation of muscle adaptation (GO:0014874)5.09214691
24cardiac muscle contraction (GO:0060048)5.07525240
25muscle atrophy (GO:0014889)4.98309144
26syncytium formation (GO:0006949)4.90258978
27male meiosis (GO:0007140)4.86873648
28myofibril assembly (GO:0030239)4.86782911
29cardiac myofibril assembly (GO:0055003)4.85046082
30negative regulation of protein localization to cell surface (GO:2000009)4.83647423
31sarcomere organization (GO:0045214)4.78984403
32sarcoplasmic reticulum calcium ion transport (GO:0070296)4.67566666
33piRNA metabolic process (GO:0034587)4.67364316
34regulation of relaxation of muscle (GO:1901077)4.60646269
35synaptonemal complex assembly (GO:0007130)4.55854452
36skeletal muscle tissue development (GO:0007519)4.42192011
37meiotic nuclear division (GO:0007126)4.40773762
38muscle cell cellular homeostasis (GO:0046716)4.30557954
39cardiac muscle cell development (GO:0055013)4.29642994
40synaptonemal complex organization (GO:0070193)4.25984084
41response to pheromone (GO:0019236)4.15948058
42regulation of striated muscle contraction (GO:0006942)4.06926944
43muscle organ development (GO:0007517)4.03998203
44muscle structure development (GO:0061061)4.03254985
45cardiac cell development (GO:0055006)4.00144841
46muscle contraction (GO:0006936)3.96545261
47skeletal muscle fiber development (GO:0048741)3.96343470
48plasma membrane repair (GO:0001778)3.93933484
49acrosome reaction (GO:0007340)3.85471648
50positive regulation of skeletal muscle tissue development (GO:0048643)3.85138444
51response to muscle activity (GO:0014850)3.83200380
52cardiac muscle hypertrophy (GO:0003300)3.81471940
53regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.77548038
54myotube cell development (GO:0014904)3.74549952
55muscle system process (GO:0003012)3.67813617
56regulation of myoblast differentiation (GO:0045661)3.62356352
57regulation of DNA endoreduplication (GO:0032875)3.60199305
58striated muscle hypertrophy (GO:0014897)3.59062180
59reciprocal DNA recombination (GO:0035825)3.58959999
60reciprocal meiotic recombination (GO:0007131)3.58959999
61actomyosin structure organization (GO:0031032)3.54884658
62fusion of sperm to egg plasma membrane (GO:0007342)3.53738630
63DNA synthesis involved in DNA repair (GO:0000731)3.53357092
64histone H3-K9 demethylation (GO:0033169)3.52805812
65striated muscle adaptation (GO:0014888)3.49984004
66negative regulation of potassium ion transport (GO:0043267)3.48783013
67regulation of acyl-CoA biosynthetic process (GO:0050812)3.47551292
68sperm motility (GO:0030317)3.47223254
69regulation of cell communication by electrical coupling (GO:0010649)3.46968916
70sperm capacitation (GO:0048240)3.45499441
71protein targeting to Golgi (GO:0000042)3.43267772
72regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.42730255
73regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.40815198
74establishment of protein localization to Golgi (GO:0072600)3.40763253
75positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.40681291
76meiotic cell cycle process (GO:1903046)3.39400260
77DNA methylation involved in gamete generation (GO:0043046)3.35754643
78regulation of skeletal muscle fiber development (GO:0048742)3.35717873
79regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.34553785
80striated muscle cell development (GO:0055002)3.33123211
81muscle fiber development (GO:0048747)3.25540750
82striated muscle tissue development (GO:0014706)3.23251721
83spermatid development (GO:0007286)3.19279954
84retrograde transport, vesicle recycling within Golgi (GO:0000301)3.14800740
85regulation of meiosis I (GO:0060631)3.13186462
86positive regulation of striated muscle cell differentiation (GO:0051155)3.12406149
87muscle hypertrophy (GO:0014896)3.11905653
88synaptic transmission, cholinergic (GO:0007271)3.07059981
89regulation of ATPase activity (GO:0043462)3.06654462
90regulation of ATP catabolic process (GO:1903289)3.06654462
91regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.06127212
92regulation of membrane repolarization (GO:0060306)3.04050799
93skeletal muscle tissue regeneration (GO:0043403)3.03149719
94regulation of cytokine production involved in inflammatory response (GO:1900015)3.01265799
95regulation of cofactor metabolic process (GO:0051193)2.99481845
96regulation of coenzyme metabolic process (GO:0051196)2.99481845
97DNA packaging (GO:0006323)2.99200169
98cardiac muscle tissue morphogenesis (GO:0055008)2.98898764
99muscle filament sliding (GO:0030049)11.0406340
100actin-myosin filament sliding (GO:0033275)11.0406340

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human6.73449711
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.16729132
3ZNF274_21170338_ChIP-Seq_K562_Hela2.84066831
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.81398953
5IGF1R_20145208_ChIP-Seq_DFB_Human2.70763485
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.54843555
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.43086409
8CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.36434673
9FUS_26573619_Chip-Seq_HEK293_Human2.35958748
10ESR1_20079471_ChIP-ChIP_T-47D_Human2.29376935
11IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.06810121
12CBP_20019798_ChIP-Seq_JUKART_Human2.06810121
13CDX2_19796622_ChIP-Seq_MESCs_Mouse1.99273391
14P300_19829295_ChIP-Seq_ESCs_Human1.95619483
15TAF15_26573619_Chip-Seq_HEK293_Human1.87043199
16CTBP2_25329375_ChIP-Seq_LNCAP_Human1.80497033
17VDR_22108803_ChIP-Seq_LS180_Human1.77001928
18ER_23166858_ChIP-Seq_MCF-7_Human1.74348124
19UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.74138485
20SMAD4_21799915_ChIP-Seq_A2780_Human1.68406345
21KLF5_20875108_ChIP-Seq_MESCs_Mouse1.67798741
22PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.58184705
23BCAT_22108803_ChIP-Seq_LS180_Human1.56897717
24MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.55933301
25SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.54972111
26NFE2_27457419_Chip-Seq_LIVER_Mouse1.54853097
27GBX2_23144817_ChIP-Seq_PC3_Human1.52928757
28POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.52432658
29TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52432658
30EZH2_22144423_ChIP-Seq_EOC_Human1.51224714
31SUZ12_27294783_Chip-Seq_NPCs_Mouse1.50744920
32HTT_18923047_ChIP-ChIP_STHdh_Human1.50193570
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50005823
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.49922701
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.47118613
36NANOG_19829295_ChIP-Seq_ESCs_Human1.46683184
37SOX2_19829295_ChIP-Seq_ESCs_Human1.46683184
38SMAD4_21741376_ChIP-Seq_EPCs_Human1.43323947
39EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.43224054
40EZH2_27294783_Chip-Seq_NPCs_Mouse1.42410698
41EP300_21415370_ChIP-Seq_HL-1_Mouse1.40918742
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40396647
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.39914003
44NANOG_18555785_Chip-Seq_ESCs_Mouse1.38695758
45STAT3_18555785_Chip-Seq_ESCs_Mouse1.38634396
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.38503563
47RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37463379
48CRX_20693478_ChIP-Seq_RETINA_Mouse1.37178255
49SALL4_22934838_ChIP-ChIP_CD34+_Human1.36505001
50TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35778899
51E2F1_18555785_Chip-Seq_ESCs_Mouse1.34693617
52MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.33303893
53CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.32267896
54FLI1_27457419_Chip-Seq_LIVER_Mouse1.31816409
55STAT3_23295773_ChIP-Seq_U87_Human1.31159094
56CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.30947350
57TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.30421546
58RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.30396468
59PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28801172
60PCGF2_27294783_Chip-Seq_NPCs_Mouse1.28505190
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.23398691
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.23084348
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21540990
64TCF4_22108803_ChIP-Seq_LS180_Human1.21186775
65P53_22387025_ChIP-Seq_ESCs_Mouse1.21100439
66OCT4_18555785_Chip-Seq_ESCs_Mouse1.19805987
67RNF2_27304074_Chip-Seq_NSC_Mouse1.19263347
68FOXA1_21572438_ChIP-Seq_LNCaP_Human1.19078728
69EGR1_23403033_ChIP-Seq_LIVER_Mouse1.18257592
70TCF4_23295773_ChIP-Seq_U87_Human1.17559094
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17191621
72EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17154328
73ZFX_18555785_Chip-Seq_ESCs_Mouse1.16021757
74TP53_18474530_ChIP-ChIP_U2OS_Human1.15852202
75AUTS2_25519132_ChIP-Seq_293T-REX_Human1.13541165
76OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12763911
77RUNX1_27457419_Chip-Seq_LIVER_Mouse1.12613481
78SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11005300
79RUNX2_22187159_ChIP-Seq_PCA_Human1.10429523
80SOX2_18555785_Chip-Seq_ESCs_Mouse1.09916360
81AR_25329375_ChIP-Seq_VCAP_Human1.09825609
82SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.09579867
83CTCF_18555785_Chip-Seq_ESCs_Mouse1.09192623
84P300_18555785_Chip-Seq_ESCs_Mouse1.09154444
85TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09095609
86FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.08584478
87CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08297405
88NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08160971
89SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07298463
90OCT4_20526341_ChIP-Seq_ESCs_Human1.06889188
91OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06880141
92KDM2B_26808549_Chip-Seq_REH_Human1.06155412
93SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05652869
94EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.04268682
95CDX2_22108803_ChIP-Seq_LS180_Human1.03547404
96GATA3_26560356_Chip-Seq_TH1_Human1.03168381
97KLF4_18555785_Chip-Seq_ESCs_Mouse1.02357335
98* MYC_19829295_ChIP-Seq_ESCs_Human0.98388940
99ERG_20517297_ChIP-Seq_VCAP_Human0.97634238
100CMYC_18555785_Chip-Seq_ESCs_Mouse0.97144505

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000749_muscle_degeneration6.27191812
2MP0004084_abnormal_cardiac_muscle5.18709129
3MP0004145_abnormal_muscle_electrophysio4.21150369
4MP0004036_abnormal_muscle_relaxation3.98003266
5MP0000751_myopathy3.95863574
6MP0004484_altered_response_of3.73233857
7MP0003950_abnormal_plasma_membrane3.46676430
8MP0005330_cardiomyopathy2.98725602
9MP0002837_dystrophic_cardiac_calcinosis2.95694851
10MP0004215_abnormal_myocardial_fiber2.81335788
11MP0002269_muscular_atrophy2.79019287
12MP0004087_abnormal_muscle_fiber2.62227919
13MP0000759_abnormal_skeletal_muscle2.61930711
14MP0005620_abnormal_muscle_contractility2.61511659
15MP0003878_abnormal_ear_physiology2.59578314
16MP0005377_hearing/vestibular/ear_phenot2.59578314
17MP0004233_abnormal_muscle_weight2.45388719
18MP0002972_abnormal_cardiac_muscle2.44541632
19MP0000747_muscle_weakness2.43169706
20MP0005410_abnormal_fertilization2.42852036
21MP0002106_abnormal_muscle_physiology2.30171462
22MP0002822_catalepsy2.30133334
23MP0004270_analgesia2.21468928
24MP0008877_abnormal_DNA_methylation2.15175556
25MP0005369_muscle_phenotype2.10977515
26MP0002108_abnormal_muscle_morphology2.00051132
27MP0000733_abnormal_muscle_development1.95967693
28MP0000750_abnormal_muscle_regeneration1.85569527
29MP0008775_abnormal_heart_ventricle1.76785168
30MP0010630_abnormal_cardiac_muscle1.68423932
31MP0001929_abnormal_gametogenesis1.64104983
32MP0002160_abnormal_reproductive_system1.54487240
33MP0004510_myositis1.53089012
34MP0003698_abnormal_male_reproductive1.48039733
35MP0002127_abnormal_cardiovascular_syste1.44428110
36MP0003646_muscle_fatigue1.44294540
37MP0003137_abnormal_impulse_conducting1.43881373
38MP0002210_abnormal_sex_determination1.38772125
39MP0009697_abnormal_copulation1.33468518
40MP0010030_abnormal_orbit_morphology1.29519413
41MP0004085_abnormal_heartbeat1.27448249
42MP0001544_abnormal_cardiovascular_syste1.27344621
43MP0005385_cardiovascular_system_phenoty1.27344621
44MP0002332_abnormal_exercise_endurance1.24258814
45MP0003828_pulmonary_edema1.23063381
46MP0002102_abnormal_ear_morphology1.18226477
47MP0002132_abnormal_respiratory_system1.11512417
48MP0002249_abnormal_larynx_morphology1.09498977
49MP0003567_abnormal_fetal_cardiomyocyte1.03315577
50MP0001485_abnormal_pinna_reflex1.03210930
51MP0001542_abnormal_bone_strength1.02923205
52MP0001145_abnormal_male_reproductive1.02252295
53MP0000653_abnormal_sex_gland1.01716841
54MP0004147_increased_porphyrin_level1.00690330
55MP0005670_abnormal_white_adipose0.97999055
56MP0001986_abnormal_taste_sensitivity0.94874457
57MP0006036_abnormal_mitochondrial_physio0.92200185
58MP0000372_irregular_coat_pigmentation0.89817348
59MP0005389_reproductive_system_phenotype0.88644490
60MP0003122_maternal_imprinting0.86511264
61MP0002971_abnormal_brown_adipose0.79688025
62MP0008789_abnormal_olfactory_epithelium0.79122098
63MP0001299_abnormal_eye_distance/0.77650146
64MP0003121_genomic_imprinting0.73114805
65MP0008995_early_reproductive_senescence0.71911587
66MP0002138_abnormal_hepatobiliary_system0.71817533
67MP0005266_abnormal_metabolism0.70966481
68MP0001486_abnormal_startle_reflex0.70911534
69MP0000266_abnormal_heart_morphology0.67979629
70MP0005248_abnormal_Harderian_gland0.67314357
71MP0005275_abnormal_skin_tensile0.65913356
72MP0008004_abnormal_stomach_pH0.65734124
73MP0003221_abnormal_cardiomyocyte_apopto0.65499153
74MP0003718_maternal_effect0.64209469
75MP0002161_abnormal_fertility/fecundity0.60612002
76MP0003941_abnormal_skin_development0.59662154
77MP0005187_abnormal_penis_morphology0.56742081
78MP0000647_abnormal_sebaceous_gland0.55937398
79MP0006276_abnormal_autonomic_nervous0.55397271
80MP0001119_abnormal_female_reproductive0.54084360
81MP0003656_abnormal_erythrocyte_physiolo0.53684583
82MP0002734_abnormal_mechanical_nocicepti0.53250277
83MP0003115_abnormal_respiratory_system0.52907965
84MP0008058_abnormal_DNA_repair0.51717475
85MP0000569_abnormal_digit_pigmentation0.50778331
86MP0006054_spinal_hemorrhage0.49888607
87MP0004264_abnormal_extraembryonic_tissu0.47938316
88MP0002114_abnormal_axial_skeleton0.47266006
89MP0000230_abnormal_systemic_arterial0.45666484
90MP0000427_abnormal_hair_cycle0.44574001
91MP0010678_abnormal_skin_adnexa0.43698047
92MP0005551_abnormal_eye_electrophysiolog0.43062909
93MP0000383_abnormal_hair_follicle0.42571845
94MP0000762_abnormal_tongue_morphology0.41282196
95MP0005165_increased_susceptibility_to0.39359304
96MP0003385_abnormal_body_wall0.39152162
97MP0001661_extended_life_span0.37740918
98MP0005395_other_phenotype0.37601102
99MP0000678_abnormal_parathyroid_gland0.37564601
100MP0008438_abnormal_cutaneous_collagen0.37467109

Predicted human phenotypes

RankGene SetZ-score
1Popliteal pterygium (HP:0009756)9.92635910
2Amniotic constriction ring (HP:0009775)7.96095762
3Abnormality of placental membranes (HP:0011409)7.96095762
4Type 2 muscle fiber atrophy (HP:0003554)7.59439784
5Distal arthrogryposis (HP:0005684)7.57821602
6Fetal akinesia sequence (HP:0001989)7.13373479
7Muscle fiber atrophy (HP:0100295)6.70910216
8Round ear (HP:0100830)6.46027998
9Aplasia of the musculature (HP:0100854)6.43256735
10Ulnar deviation of the wrist (HP:0003049)6.31890068
11Malignant hyperthermia (HP:0002047)5.73796137
12Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.49023952
13Abnormality of the neuromuscular junction (HP:0003398)5.48495820
14Fatigable weakness (HP:0003473)5.48495820
15Weak cry (HP:0001612)5.34494753
16Calf muscle hypertrophy (HP:0008981)5.23388239
17Calcaneovalgus deformity (HP:0001848)5.22182505
18Hyporeflexia of lower limbs (HP:0002600)5.14474118
19Muscle fiber inclusion bodies (HP:0100299)4.94242214
20Nemaline bodies (HP:0003798)4.73933495
21Akinesia (HP:0002304)4.65911772
22Deformed tarsal bones (HP:0008119)4.62995088
23Muscle hypertrophy of the lower extremities (HP:0008968)4.62691976
24Absent phalangeal crease (HP:0006109)4.61496739
25Gowers sign (HP:0003391)4.27458963
26Aplasia/Hypoplasia involving the musculature (HP:0001460)4.23232146
27Pterygium (HP:0001059)4.08570425
28Asymmetric septal hypertrophy (HP:0001670)4.04949763
29Thin ribs (HP:0000883)4.01720276
30Abnormal finger flexion creases (HP:0006143)3.95159091
31Easy fatigability (HP:0003388)3.71316764
32Muscle fiber splitting (HP:0003555)3.70874491
33Sudden death (HP:0001699)3.64569110
34Abnormality of the calf musculature (HP:0001430)3.55123729
35Areflexia of lower limbs (HP:0002522)3.40409323
36Cystic hygroma (HP:0000476)3.38941332
37Abnormality of the calcaneus (HP:0008364)3.35491160
38Hypoplastic heart (HP:0001961)3.24228480
39Distal lower limb muscle weakness (HP:0009053)3.18887141
40Type 1 muscle fiber predominance (HP:0003803)2.87704608
41Neck muscle weakness (HP:0000467)2.87652821
42Ventricular tachycardia (HP:0004756)2.65916354
43EMG: neuropathic changes (HP:0003445)2.65818946
44Webbed neck (HP:0000465)2.64566337
45EMG: myopathic abnormalities (HP:0003458)2.63777419
46Bulbar palsy (HP:0001283)2.63382345
47Exercise-induced myalgia (HP:0003738)2.62556469
48Bundle branch block (HP:0011710)2.61362709
49Exercise-induced muscle cramps (HP:0003710)2.49781564
50Rimmed vacuoles (HP:0003805)2.44483441
51Abnormalities of placenta or umbilical cord (HP:0001194)2.39747027
52Poor suck (HP:0002033)2.38228182
53Diminished movement (HP:0002374)2.35368300
54Abnormality of the left ventricular outflow tract (HP:0011103)2.32818167
55Subaortic stenosis (HP:0001682)2.32818167
56Generalized muscle weakness (HP:0003324)2.31634061
57Hip contracture (HP:0003273)2.26465995
58Metatarsus adductus (HP:0001840)2.14961587
59Respiratory insufficiency due to muscle weakness (HP:0002747)2.11551517
60Atrial fibrillation (HP:0005110)2.07797312
61Depressed nasal tip (HP:0000437)2.05530473
62Breech presentation (HP:0001623)1.99717970
63Left ventricular hypertrophy (HP:0001712)1.90979729
64Trismus (HP:0000211)1.89670800
65Proximal tubulopathy (HP:0000114)1.89026818
66Lipoatrophy (HP:0100578)1.86871451
67Primary atrial arrhythmia (HP:0001692)1.85296440
68Supraventricular tachycardia (HP:0004755)1.78403204
69Decreased muscle mass (HP:0003199)1.77671421
70Supraventricular arrhythmia (HP:0005115)1.72514543
71Nonprogressive disorder (HP:0003680)1.69709536
72Arthrogryposis multiplex congenita (HP:0002804)1.69303708
73Short thorax (HP:0010306)1.67125244
74Spontaneous abortion (HP:0005268)1.65824218
75Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.65015010
76Pulmonary hypoplasia (HP:0002089)1.63547728
77Limb-girdle muscle weakness (HP:0003325)1.60407716
78Increased serum pyruvate (HP:0003542)1.58889769
79Muscle stiffness (HP:0003552)1.57413064
80Dilated cardiomyopathy (HP:0001644)1.57398603
81Steppage gait (HP:0003376)1.57398242
82Limited hip movement (HP:0008800)1.57124028
83Abnormal auditory evoked potentials (HP:0006958)1.56299177
84Tubulointerstitial nephritis (HP:0001970)1.53299594
85Osteomalacia (HP:0002749)1.52035289
86Myopathic facies (HP:0002058)1.51731375
87Syncope (HP:0001279)1.49910116
88Ulnar deviation of finger (HP:0009465)1.49259011
89Long clavicles (HP:0000890)1.48296643
90Vertebral fusion (HP:0002948)1.43391329
91Absent septum pellucidum (HP:0001331)1.42540056
92Shoulder girdle muscle weakness (HP:0003547)1.40812648
93Rocker bottom foot (HP:0001838)1.40015470
94Difficulty walking (HP:0002355)1.38698755
95Symphalangism affecting the phalanges of the hand (HP:0009773)1.37655933
96Ventricular arrhythmia (HP:0004308)1.36943872
97Heart block (HP:0012722)1.34901455
98Abnormality of alanine metabolism (HP:0010916)1.32917727
99Hyperalaninemia (HP:0003348)1.32917727
100Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.32917727

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN5.50675467
2PIK3CG4.83356822
3PDK23.70608186
4MUSK3.16617954
5PLK42.96259095
6STK38L2.78309060
7CDK192.65815392
8PKN22.63927003
9PLK22.53469790
10PNCK2.43234546
11STK392.35482268
12MOS2.14230610
13STK162.08597411
14MAP4K22.03108433
15LATS11.95714933
16LIMK11.91344920
17OXSR11.90239546
18CCNB11.81534269
19DDR21.56180563
20PTK2B1.55394633
21FLT31.41159158
22WNK41.38577969
23MAPK131.36612785
24MET1.36244951
25ARAF1.30798153
26KSR21.28294350
27FRK1.28158764
28INSRR1.26205434
29NEK91.23311153
30MAP3K121.22681103
31MAP3K91.22680932
32STK381.18209665
33BRD41.16822470
34AKT31.14346046
35ACVR1B1.12788401
36MYLK1.08146261
37MST41.08109799
38RAF11.07643333
39TESK11.05219605
40MAP3K131.02546059
41PIK3CA0.94664310
42NUAK10.93370483
43TNIK0.92847708
44KSR10.90101150
45MAP3K50.89467057
46NEK10.85485038
47PDK10.82683354
48PRKG10.80850489
49PRKG20.79680536
50FGR0.78975434
51BRAF0.78277149
52ERBB30.77308407
53LATS20.76294952
54WNK10.73290088
55MAP2K10.71580357
56IRAK20.67490748
57PRKD30.64828257
58DAPK20.61805798
59NEK60.59566065
60NME10.58910096
61DYRK1B0.56674359
62CAMK2A0.56014282
63PDPK10.54692063
64GRK70.53206487
65ROCK10.51448725
66CASK0.51309905
67EGFR0.50006463
68FER0.49997944
69PKN10.48622571
70BMPR1B0.48535901
71PRKACB0.46104844
72RET0.44517962
73MAP3K20.43808732
74DYRK1A0.42026591
75NTRK30.41727454
76MAPK110.41625475
77PAK30.41144233
78PBK0.40897120
79BRSK20.37789538
80BRSK10.37619819
81CAMK10.37435998
82MAP3K40.36264368
83DMPK0.35227181
84STK30.33890453
85BCKDK0.32984138
86EIF2AK30.31510202
87CSNK1D0.30830740
88MAP3K70.28733975
89PRKCE0.28549408
90IRAK10.27897947
91SGK10.26379790
92RPS6KB10.25593952
93MAPK70.23000746
94FGFR10.22703377
95PRKAA10.21586299
96AKT20.19991974
97PRKACA0.19979409
98MARK10.19706193
99WNK30.18765613
100IGF1R0.18508386

Predicted pathways (KEGG)

RankGene SetZ-score
1Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.77774609
2Cardiac muscle contraction_Homo sapiens_hsa042604.43480252
3Dilated cardiomyopathy_Homo sapiens_hsa054144.21080876
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.38372733
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.75580715
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.32394874
7Propanoate metabolism_Homo sapiens_hsa006402.17475164
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.10274437
9Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.99422689
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.86836000
11Phototransduction_Homo sapiens_hsa047441.84151615
12Olfactory transduction_Homo sapiens_hsa047401.76789383
13Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.65039648
14Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.62021256
15Pyruvate metabolism_Homo sapiens_hsa006201.60426012
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.59004439
17Tight junction_Homo sapiens_hsa045301.58441264
18Primary bile acid biosynthesis_Homo sapiens_hsa001201.54661550
19Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.51697138
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.49431997
21Butanoate metabolism_Homo sapiens_hsa006501.41087443
22Basal transcription factors_Homo sapiens_hsa030221.39076596
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.38757815
24Parkinsons disease_Homo sapiens_hsa050121.34813600
25Regulation of autophagy_Homo sapiens_hsa041401.24983159
26Carbon metabolism_Homo sapiens_hsa012001.24256103
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.21353656
28Calcium signaling pathway_Homo sapiens_hsa040201.21331088
29Arginine and proline metabolism_Homo sapiens_hsa003301.20947955
30Dorso-ventral axis formation_Homo sapiens_hsa043201.18219288
31Focal adhesion_Homo sapiens_hsa045101.05817171
32Protein digestion and absorption_Homo sapiens_hsa049741.04659525
33RNA transport_Homo sapiens_hsa030131.04373795
34Linoleic acid metabolism_Homo sapiens_hsa005911.02846289
35Fat digestion and absorption_Homo sapiens_hsa049750.98794529
36RNA degradation_Homo sapiens_hsa030180.98049814
37Oocyte meiosis_Homo sapiens_hsa041140.96396102
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.96271610
39Huntingtons disease_Homo sapiens_hsa050160.96266312
40Oxytocin signaling pathway_Homo sapiens_hsa049210.95594464
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92302414
42Biosynthesis of amino acids_Homo sapiens_hsa012300.89605670
43PPAR signaling pathway_Homo sapiens_hsa033200.89497354
44Circadian rhythm_Homo sapiens_hsa047100.88696959
45cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87635108
46Vascular smooth muscle contraction_Homo sapiens_hsa042700.86868129
47Oxidative phosphorylation_Homo sapiens_hsa001900.85235102
48Viral myocarditis_Homo sapiens_hsa054160.84714289
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83490139
50Proteasome_Homo sapiens_hsa030500.83414703
51Retinol metabolism_Homo sapiens_hsa008300.81344029
52Caffeine metabolism_Homo sapiens_hsa002320.80083383
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.79949066
54Renin-angiotensin system_Homo sapiens_hsa046140.79869136
55Steroid hormone biosynthesis_Homo sapiens_hsa001400.76711579
56Fatty acid degradation_Homo sapiens_hsa000710.74439681
57ECM-receptor interaction_Homo sapiens_hsa045120.73774955
58Alzheimers disease_Homo sapiens_hsa050100.72498778
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72034233
60Regulation of actin cytoskeleton_Homo sapiens_hsa048100.71471898
61Arginine biosynthesis_Homo sapiens_hsa002200.71279213
62Phenylalanine metabolism_Homo sapiens_hsa003600.69519434
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.68068475
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67822574
65Fatty acid biosynthesis_Homo sapiens_hsa000610.65964651
66Non-homologous end-joining_Homo sapiens_hsa034500.64687332
67Ether lipid metabolism_Homo sapiens_hsa005650.63247341
68ABC transporters_Homo sapiens_hsa020100.60307929
69Sulfur relay system_Homo sapiens_hsa041220.58821723
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55258418
71HIF-1 signaling pathway_Homo sapiens_hsa040660.54528516
72Taste transduction_Homo sapiens_hsa047420.51101887
73Hedgehog signaling pathway_Homo sapiens_hsa043400.49982562
74Glucagon signaling pathway_Homo sapiens_hsa049220.49907768
75Fatty acid elongation_Homo sapiens_hsa000620.49524523
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48970670
77Chemical carcinogenesis_Homo sapiens_hsa052040.47970900
78Salivary secretion_Homo sapiens_hsa049700.47196022
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44926321
80Fanconi anemia pathway_Homo sapiens_hsa034600.44139336
81Peroxisome_Homo sapiens_hsa041460.43855041
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.40525526
83Small cell lung cancer_Homo sapiens_hsa052220.40264963
84Selenocompound metabolism_Homo sapiens_hsa004500.39046691
85beta-Alanine metabolism_Homo sapiens_hsa004100.38892412
86p53 signaling pathway_Homo sapiens_hsa041150.38327310
87TGF-beta signaling pathway_Homo sapiens_hsa043500.37863770
88Adherens junction_Homo sapiens_hsa045200.37794393
89Leukocyte transendothelial migration_Homo sapiens_hsa046700.37634164
90Metabolic pathways_Homo sapiens_hsa011000.37023705
91Fatty acid metabolism_Homo sapiens_hsa012120.34433569
92Starch and sucrose metabolism_Homo sapiens_hsa005000.34086094
93Thyroid cancer_Homo sapiens_hsa052160.33806301
94Mineral absorption_Homo sapiens_hsa049780.32731316
95Arachidonic acid metabolism_Homo sapiens_hsa005900.31164577
96Inositol phosphate metabolism_Homo sapiens_hsa005620.30399409
97Nitrogen metabolism_Homo sapiens_hsa009100.29325771
98Vitamin digestion and absorption_Homo sapiens_hsa049770.27190882
99Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.26043623
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24381281

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