C1ORF101

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)9.17810409
2cilium or flagellum-dependent cell motility (GO:0001539)7.22667166
3epithelial cilium movement (GO:0003351)6.76165176
4DNA methylation involved in gamete generation (GO:0043046)6.72803130
5cilium movement (GO:0003341)6.65032619
6male meiosis (GO:0007140)6.40593816
7synapsis (GO:0007129)6.37590988
8male meiosis I (GO:0007141)6.34184067
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.66733741
10chromosome organization involved in meiosis (GO:0070192)5.61162230
11regulation of meiosis I (GO:0060631)5.56588204
12axoneme assembly (GO:0035082)5.54854301
13axonemal dynein complex assembly (GO:0070286)5.31323655
14regulation of cilium movement (GO:0003352)5.22948876
15meiosis I (GO:0007127)5.21543900
16meiotic nuclear division (GO:0007126)5.08454769
17centriole replication (GO:0007099)5.08217329
18negative regulation of cAMP-mediated signaling (GO:0043951)5.00562605
19intraciliary transport (GO:0042073)4.84038160
20synaptonemal complex assembly (GO:0007130)4.69959174
21synaptonemal complex organization (GO:0070193)4.58792791
22photoreceptor cell maintenance (GO:0045494)4.53115205
23centriole assembly (GO:0098534)4.20254267
24sperm motility (GO:0030317)4.00913058
25DNA synthesis involved in DNA repair (GO:0000731)3.96035362
26negative regulation of cytosolic calcium ion concentration (GO:0051481)3.95256423
27positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.91310043
28spermatid development (GO:0007286)3.86764678
29left/right axis specification (GO:0070986)3.83654362
30positive regulation of prostaglandin secretion (GO:0032308)3.80824903
31motile cilium assembly (GO:0044458)3.76923682
32gene silencing by RNA (GO:0031047)3.69116259
33regulation of microtubule-based movement (GO:0060632)3.68553603
34histone H4-K12 acetylation (GO:0043983)3.57296956
35ventricular system development (GO:0021591)3.57178968
36platelet dense granule organization (GO:0060155)3.52862426
37rRNA methylation (GO:0031167)3.52006131
38meiotic cell cycle process (GO:1903046)3.48376970
39reciprocal meiotic recombination (GO:0007131)3.47499438
40reciprocal DNA recombination (GO:0035825)3.47499438
41positive regulation of meiosis (GO:0045836)3.42400363
42RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.40774005
43sister chromatid cohesion (GO:0007062)3.31971437
44positive regulation of icosanoid secretion (GO:0032305)3.30208065
45thrombin receptor signaling pathway (GO:0070493)3.28922694
46cilium morphogenesis (GO:0060271)3.24968602
47histone H3-K36 demethylation (GO:0070544)3.21419267
48acrosome reaction (GO:0007340)3.20502339
49positive regulation of fatty acid transport (GO:2000193)3.20224961
50cilium organization (GO:0044782)3.16326532
51regulation of DNA endoreduplication (GO:0032875)3.11720064
52positive regulation of meiotic cell cycle (GO:0051446)3.10185889
53cilium assembly (GO:0042384)3.09190478
54neuronal action potential (GO:0019228)3.04634990
55meiotic chromosome segregation (GO:0045132)3.02952884
56regulation of protein glycosylation (GO:0060049)3.00895366
57regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.98981472
58signal complex assembly (GO:0007172)2.95671489
59regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.94936915
60signal peptide processing (GO:0006465)2.93312382
61behavioral response to nicotine (GO:0035095)2.92718911
62DNA deamination (GO:0045006)2.88168372
63regulation of prostaglandin secretion (GO:0032306)2.86746792
64regulation of acrosome reaction (GO:0060046)2.82560650
65rRNA modification (GO:0000154)2.81851138
66single strand break repair (GO:0000012)2.74893780
67regulation of female receptivity (GO:0045924)2.74438489
68fertilization (GO:0009566)2.72321247
69growth hormone receptor signaling pathway (GO:0060396)2.71430155
70peroxisome fission (GO:0016559)2.70493537
71dopamine transport (GO:0015872)2.69805770
72behavioral response to ethanol (GO:0048149)2.69506614
73histone H3-K9 demethylation (GO:0033169)2.69322142
74cardiolipin metabolic process (GO:0032048)2.67996702
75melanosome organization (GO:0032438)2.67311112
76artery smooth muscle contraction (GO:0014824)2.66058867
77protein polyglutamylation (GO:0018095)2.65476016
78seminiferous tubule development (GO:0072520)2.63819103
79G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.63660858
80positive regulation of response to oxidative stress (GO:1902884)2.61328655
81positive regulation of cellular response to oxidative stress (GO:1900409)2.61328655
82mismatch repair (GO:0006298)2.61145734
83anterograde synaptic vesicle transport (GO:0048490)2.60970965
84resolution of meiotic recombination intermediates (GO:0000712)2.58132707
85rRNA catabolic process (GO:0016075)2.57222876
86mature B cell differentiation (GO:0002335)2.55115775
87regulation of type B pancreatic cell apoptotic process (GO:2000674)2.55028475
88regulation of histone H3-K9 methylation (GO:0051570)2.53804867
89female mating behavior (GO:0060180)2.51394323
90microtubule bundle formation (GO:0001578)2.50755987
91microtubule severing (GO:0051013)2.49027638
92pigment granule organization (GO:0048753)2.48807634
93endosome to melanosome transport (GO:0035646)2.48254664
94endosome to pigment granule transport (GO:0043485)2.48254664
95establishment of nucleus localization (GO:0040023)2.47793123
96ADP metabolic process (GO:0046031)2.47751818
97brain morphogenesis (GO:0048854)2.46873770
98spermatogenesis (GO:0007283)2.45399544
99male gamete generation (GO:0048232)2.45251073
100cellular component assembly involved in morphogenesis (GO:0010927)2.43329954

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.98318830
2PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.77921463
3IGF1R_20145208_ChIP-Seq_DFB_Human3.12169786
4* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.71251239
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.48690691
6FUS_26573619_Chip-Seq_HEK293_Human2.35682403
7VDR_22108803_ChIP-Seq_LS180_Human2.33683277
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.17950224
9GBX2_23144817_ChIP-Seq_PC3_Human2.15915951
10ZNF274_21170338_ChIP-Seq_K562_Hela2.11034685
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.07445564
12ER_23166858_ChIP-Seq_MCF-7_Human2.03593047
13IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.95359139
14CBP_20019798_ChIP-Seq_JUKART_Human1.95359139
15BCAT_22108803_ChIP-Seq_LS180_Human1.89155811
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.87681243
17CTBP2_25329375_ChIP-Seq_LNCAP_Human1.86710796
18RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.84661093
19TCF4_23295773_ChIP-Seq_U87_Human1.82626011
20STAT3_23295773_ChIP-Seq_U87_Human1.82623028
21SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.78925989
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.78111148
23EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.76888121
24AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.76042839
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.74002252
26SMAD4_21799915_ChIP-Seq_A2780_Human1.72423531
27P300_19829295_ChIP-Seq_ESCs_Human1.68464020
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.65938846
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.65002506
30UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.55448241
31TP53_22573176_ChIP-Seq_HFKS_Human1.54804616
32FOXA1_21572438_ChIP-Seq_LNCaP_Human1.52129954
33NANOG_19829295_ChIP-Seq_ESCs_Human1.47741500
34SOX2_19829295_ChIP-Seq_ESCs_Human1.47741500
35POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.46691209
36TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46691209
37EGR1_23403033_ChIP-Seq_LIVER_Mouse1.46067167
38TAF15_26573619_Chip-Seq_HEK293_Human1.45734186
39KLF5_20875108_ChIP-Seq_MESCs_Mouse1.45243662
40EWS_26573619_Chip-Seq_HEK293_Human1.44328261
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.42356854
42VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.42125104
43EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.41804487
44CDX2_19796622_ChIP-Seq_MESCs_Mouse1.38837308
45TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36562803
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.32642784
47RUNX2_22187159_ChIP-Seq_PCA_Human1.31325022
48NFE2_27457419_Chip-Seq_LIVER_Mouse1.30918244
49MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30663454
50BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.29912179
51* AR_25329375_ChIP-Seq_VCAP_Human1.29864265
52FOXA1_25329375_ChIP-Seq_VCAP_Human1.29433744
53FOXA1_27270436_Chip-Seq_PROSTATE_Human1.29433744
54MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.29415555
55TCF4_22108803_ChIP-Seq_LS180_Human1.28075852
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.26915256
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25182437
58CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.24014592
59PRDM14_20953172_ChIP-Seq_ESCs_Human1.23762568
60IRF8_21731497_ChIP-ChIP_J774_Mouse1.23015654
61EZH2_27294783_Chip-Seq_NPCs_Mouse1.22490671
62FLI1_21867929_ChIP-Seq_TH2_Mouse1.21960236
63FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.20541139
64CDX2_22108803_ChIP-Seq_LS180_Human1.19027880
65TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17428692
66SMAD4_21741376_ChIP-Seq_EPCs_Human1.16116907
67CRX_20693478_ChIP-Seq_RETINA_Mouse1.14632445
68IRF8_22096565_ChIP-ChIP_GC-B_Human1.13900791
69GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13883394
70FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.13494321
71* PHF8_20622853_ChIP-Seq_HELA_Human1.11517253
72NANOG_18555785_Chip-Seq_ESCs_Mouse1.11439127
73TAL1_26923725_Chip-Seq_HPCs_Mouse1.09796753
74HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.09596643
75TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.09333336
76ELF1_17652178_ChIP-ChIP_JURKAT_Human1.08491294
77RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07376183
78TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.05850847
79E2F1_18555785_Chip-Seq_ESCs_Mouse1.04495573
80AR_20517297_ChIP-Seq_VCAP_Human1.04260797
81PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.04209340
82PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04093624
83GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.03808018
84TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03168267
85* ETV1_20927104_ChIP-Seq_GIST48_Human1.02967792
86ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01555413
87CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00756244
88STAT3_18555785_Chip-Seq_ESCs_Mouse1.00630353
89AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00420213
90FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00303314
91ETV2_25802403_ChIP-Seq_MESCs_Mouse0.99541144
92CTCF_18555785_Chip-Seq_ESCs_Mouse0.98563588
93STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.98251087
94GATA3_21878914_ChIP-Seq_MCF-7_Human0.98232654
95P300_18555785_Chip-Seq_ESCs_Mouse0.97629144
96* NFYB_21822215_ChIP-Seq_K562_Human0.97399394
97* PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.97159076
98RXR_22108803_ChIP-Seq_LS180_Human0.96872322
99SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.96615819
100NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96387514

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation6.34281413
2MP0000569_abnormal_digit_pigmentation4.91178401
3MP0000015_abnormal_ear_pigmentation3.43359281
4MP0008057_abnormal_DNA_replication3.19946809
5MP0008058_abnormal_DNA_repair3.05586623
6MP0002876_abnormal_thyroid_physiology2.80073965
7MP0002638_abnormal_pupillary_reflex2.78673635
8MP0005174_abnormal_tail_pigmentation2.70872685
9MP0005645_abnormal_hypothalamus_physiol2.36597396
10MP0001501_abnormal_sleep_pattern2.33042835
11MP0000383_abnormal_hair_follicle2.32191334
12MP0010678_abnormal_skin_adnexa2.26061854
13MP0010386_abnormal_urinary_bladder2.25541952
14MP0001929_abnormal_gametogenesis2.24667773
15MP0009278_abnormal_bone_marrow2.24353895
16MP0009780_abnormal_chondrocyte_physiolo2.18266853
17MP0003698_abnormal_male_reproductive2.07862780
18MP0003787_abnormal_imprinting2.06067958
19MP0005551_abnormal_eye_electrophysiolog1.95366675
20MP0003195_calcinosis1.94843721
21MP0002210_abnormal_sex_determination1.86307021
22MP0005083_abnormal_biliary_tract1.83513772
23MP0005410_abnormal_fertilization1.82270989
24MP0000427_abnormal_hair_cycle1.73398990
25MP0005075_abnormal_melanosome_morpholog1.70114646
26MP0005310_abnormal_salivary_gland1.67895842
27MP0001984_abnormal_olfaction1.64420457
28MP0002160_abnormal_reproductive_system1.61512413
29MP0006036_abnormal_mitochondrial_physio1.60047158
30MP0002095_abnormal_skin_pigmentation1.58818989
31MP0010234_abnormal_vibrissa_follicle1.56269570
32MP0000371_diluted_coat_color1.55752946
33MP0005397_hematopoietic_system_phenotyp1.54744237
34MP0001545_abnormal_hematopoietic_system1.54744237
35MP0001145_abnormal_male_reproductive1.49109315
36MP0005084_abnormal_gallbladder_morpholo1.49105907
37MP0000653_abnormal_sex_gland1.47126787
38MP0005253_abnormal_eye_physiology1.36057179
39MP0002971_abnormal_brown_adipose1.33395389
40MP0003011_delayed_dark_adaptation1.30975181
41MP0005408_hypopigmentation1.25185347
42MP0003718_maternal_effect1.24866515
43MP0000013_abnormal_adipose_tissue1.24157672
44MP0003806_abnormal_nucleotide_metabolis1.23697461
45MP0003186_abnormal_redox_activity1.23566658
46MP0002928_abnormal_bile_duct1.22655160
47MP0008995_early_reproductive_senescence1.22594387
48MP0003646_muscle_fatigue1.20893549
49MP0006035_abnormal_mitochondrial_morpho1.17604613
50MP0005646_abnormal_pituitary_gland1.17132296
51MP0000372_irregular_coat_pigmentation1.16832369
52MP0005167_abnormal_blood-brain_barrier1.15903342
53MP0006072_abnormal_retinal_apoptosis1.14145871
54MP0003252_abnormal_bile_duct1.11698334
55MP0003786_premature_aging1.10614035
56MP0005389_reproductive_system_phenotype1.08016257
57MP0003633_abnormal_nervous_system1.07827652
58MP0000681_abnormal_thyroid_gland1.07299195
59MP0009046_muscle_twitch1.02627219
60MP0002693_abnormal_pancreas_physiology1.01669993
61MP0001324_abnormal_eye_pigmentation1.00970263
62MP0005395_other_phenotype0.99114442
63MP0002168_other_aberrant_phenotype0.96703105
64MP0000358_abnormal_cell_content/0.96551631
65MP0004019_abnormal_vitamin_homeostasis0.95507471
66MP0003172_abnormal_lysosome_physiology0.94822317
67MP0005266_abnormal_metabolism0.94090264
68MP0002229_neurodegeneration0.93254136
69MP0003943_abnormal_hepatobiliary_system0.93174998
70MP0001968_abnormal_touch/_nociception0.92243190
71MP0006276_abnormal_autonomic_nervous0.90947694
72MP0000003_abnormal_adipose_tissue0.90940435
73MP0005365_abnormal_bile_salt0.89603948
74MP0002272_abnormal_nervous_system0.87055623
75MP0005220_abnormal_exocrine_pancreas0.85553405
76MP0001764_abnormal_homeostasis0.84099084
77MP0000538_abnormal_urinary_bladder0.80471022
78MP0005464_abnormal_platelet_physiology0.79987869
79MP0004147_increased_porphyrin_level0.78377211
80MP0009745_abnormal_behavioral_response0.78345358
81MP0008875_abnormal_xenobiotic_pharmacok0.77891780
82MP0002653_abnormal_ependyma_morphology0.77634912
83MP0002161_abnormal_fertility/fecundity0.77486043
84MP0005386_behavior/neurological_phenoty0.77161347
85MP0004924_abnormal_behavior0.77161347
86MP0003191_abnormal_cellular_cholesterol0.75389040
87MP0002877_abnormal_melanocyte_morpholog0.75035452
88MP0004043_abnormal_pH_regulation0.74237205
89MP0001664_abnormal_digestion0.73021164
90MP0000230_abnormal_systemic_arterial0.72260428
91MP0005670_abnormal_white_adipose0.71085635
92MP0001944_abnormal_pancreas_morphology0.70800195
93MP0006054_spinal_hemorrhage0.68216199
94MP0005171_absent_coat_pigmentation0.67660149
95MP0004742_abnormal_vestibular_system0.67386565
96MP0003136_yellow_coat_color0.66547258
97MP0003045_fibrosis0.66295174
98MP0010094_abnormal_chromosome_stability0.65993945
99MP0001119_abnormal_female_reproductive0.65840811
100MP0003183_abnormal_peptide_metabolism0.63721130

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.18817047
2Abnormal ciliary motility (HP:0012262)4.87482652
3Abnormal respiratory motile cilium morphology (HP:0005938)4.75941710
4Abnormal respiratory epithelium morphology (HP:0012253)4.75941710
5Tubulointerstitial nephritis (HP:0001970)4.68883962
6Abnormal respiratory motile cilium physiology (HP:0012261)4.64144735
7Volvulus (HP:0002580)4.46375081
8Medial flaring of the eyebrow (HP:0010747)4.43282171
9Absent/shortened dynein arms (HP:0200106)4.37378356
10Dynein arm defect of respiratory motile cilia (HP:0012255)4.37378356
11Congenital primary aphakia (HP:0007707)4.06216702
12Gait imbalance (HP:0002141)3.97566659
13Rhinitis (HP:0012384)3.89331382
14Nephrogenic diabetes insipidus (HP:0009806)3.69207862
15Albinism (HP:0001022)3.62833852
16Nephronophthisis (HP:0000090)3.56531334
17Chronic hepatic failure (HP:0100626)3.28411202
18Abnormality of the renal medulla (HP:0100957)3.27278034
19Type I transferrin isoform profile (HP:0003642)3.26014480
20Abnormality of macular pigmentation (HP:0008002)3.13328172
21Thyroid-stimulating hormone excess (HP:0002925)3.12107282
22Poor coordination (HP:0002370)3.01332667
23Abnormality of the renal cortex (HP:0011035)3.00810880
24Vaginal atresia (HP:0000148)2.98376013
25Horizontal nystagmus (HP:0000666)2.98302359
26Genital tract atresia (HP:0001827)2.98174215
27Menstrual irregularities (HP:0000858)2.96447941
28Tubular atrophy (HP:0000092)2.94455398
29Severe visual impairment (HP:0001141)2.92390167
30Bronchiectasis (HP:0002110)2.91546900
31Tubulointerstitial abnormality (HP:0001969)2.85879523
32Abnormal rod and cone electroretinograms (HP:0008323)2.84772482
33Pancreatic fibrosis (HP:0100732)2.79681018
34Occipital encephalocele (HP:0002085)2.79427514
35Intestinal atresia (HP:0011100)2.76538509
36Gaze-evoked nystagmus (HP:0000640)2.75422655
37Pancreatic cysts (HP:0001737)2.72710556
38Attenuation of retinal blood vessels (HP:0007843)2.68895034
39Broad distal phalanx of finger (HP:0009836)2.68857176
40Abnormality of midbrain morphology (HP:0002418)2.68079853
41Molar tooth sign on MRI (HP:0002419)2.68079853
42Retinitis pigmentosa (HP:0000510)2.63735350
43Chronic bronchitis (HP:0004469)2.55014750
44Abnormal protein glycosylation (HP:0012346)2.54988215
45Abnormal glycosylation (HP:0012345)2.54988215
46Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.54988215
47Abnormal protein N-linked glycosylation (HP:0012347)2.54988215
48Hypokalemic alkalosis (HP:0001949)2.53721433
49Absent rod-and cone-mediated responses on ERG (HP:0007688)2.53219343
50Cystic liver disease (HP:0006706)2.52196875
51Bony spicule pigmentary retinopathy (HP:0007737)2.50411702
52Focal motor seizures (HP:0011153)2.48090558
53True hermaphroditism (HP:0010459)2.47970380
54Aplasia/Hypoplasia of the lens (HP:0008063)2.41153203
55Atonic seizures (HP:0010819)2.34270567
56Polydipsia (HP:0001959)2.18284916
57Abnormal drinking behavior (HP:0030082)2.18284916
58Bile duct proliferation (HP:0001408)2.14675444
59Abnormal biliary tract physiology (HP:0012439)2.14675444
60Cutaneous melanoma (HP:0012056)2.10865829
61Astigmatism (HP:0000483)2.09319646
62Congenital hepatic fibrosis (HP:0002612)2.05971018
63Generalized hypopigmentation (HP:0007513)2.04493527
64Polyuria (HP:0000103)2.04022375
65Decreased central vision (HP:0007663)2.03849930
66Postaxial foot polydactyly (HP:0001830)2.03773953
67Microvesicular hepatic steatosis (HP:0001414)1.99451586
68Infertility (HP:0000789)1.99106971
69Ketoacidosis (HP:0001993)1.99075178
70Aplasia/Hypoplasia of the fovea (HP:0008060)1.98548749
71Hypoplasia of the fovea (HP:0007750)1.98548749
72Constricted visual fields (HP:0001133)1.97726083
73Amyotrophic lateral sclerosis (HP:0007354)1.95082632
74Pancreatic islet-cell hyperplasia (HP:0004510)1.94355350
75Progressive cerebellar ataxia (HP:0002073)1.93014142
76Abnormality of renal excretion (HP:0011036)1.92924208
77Dialeptic seizures (HP:0011146)1.89195842
78Vascular calcification (HP:0004934)1.89096294
79Nasal polyposis (HP:0100582)1.86951006
80Fair hair (HP:0002286)1.82890041
81Large for gestational age (HP:0001520)1.82363569
82Thickened helices (HP:0000391)1.80421572
83Chromosomal breakage induced by crosslinking agents (HP:0003221)1.78619275
84Multicystic kidney dysplasia (HP:0000003)1.78403511
85Broad foot (HP:0001769)1.77635583
86Neonatal respiratory distress (HP:0002643)1.73728983
87Chromsome breakage (HP:0040012)1.73568069
88Metabolic alkalosis (HP:0200114)1.73388218
89Ketosis (HP:0001946)1.73025715
90Retinal atrophy (HP:0001105)1.71791139
91Scotoma (HP:0000575)1.71332944
92Sclerocornea (HP:0000647)1.69399057
93Abnormal urine output (HP:0012590)1.69149319
94Cardiovascular calcification (HP:0011915)1.69013062
95Thrombocytosis (HP:0001894)1.67089060
96Asthma (HP:0002099)1.66746069
97Abnormality of the fovea (HP:0000493)1.65869385
98Postaxial hand polydactyly (HP:0001162)1.64405739
99Autoimmune hemolytic anemia (HP:0001890)1.64082442
100Hyperkalemia (HP:0002153)1.62956824

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK6.72580978
2FRK5.64099193
3NUAK13.48629363
4PTK2B3.13764939
5MET3.10315704
6ACVR1B2.90156382
7ADRBK22.82175419
8CAMK1G2.74874683
9BMPR1B2.49949144
10CCNB12.37890493
11BCKDK1.98469739
12CAMKK21.77083867
13PIK3CG1.75396287
14BMX1.74922696
15PLK41.70194578
16CSF1R1.64520122
17CDK191.54852171
18MAPK111.54190956
19FGR1.54068955
20FGFR21.50167033
21MST41.48471035
22NEK21.48212421
23PLK21.30525923
24FLT31.24493866
25MAPK151.24147966
26MAP4K21.21830838
27TAOK31.16322258
28EIF2AK31.14884487
29RAF11.13583559
30TGFBR11.11483212
31OXSR11.09292451
32NTRK31.08113042
33TXK1.04591546
34PASK1.02389000
35STK391.01746770
36STK38L0.98859945
37CDK30.89273853
38TESK10.87216887
39PRKCQ0.86492656
40CAMK10.85761893
41ICK0.84872063
42PINK10.84155542
43RET0.82091428
44ADRBK10.80969229
45TNK20.76482877
46MAP3K40.71297506
47LIMK10.69822295
48TEC0.68875911
49PRKCE0.68444082
50CDK90.67776331
51PDK20.67430626
52ATR0.67021992
53TAF10.64070743
54VRK20.63590752
55MST1R0.61507888
56WNK40.60884954
57ERN10.60309541
58PDGFRB0.59914691
59NEK10.59504761
60DMPK0.58502267
61MARK30.55380795
62CASK0.54939618
63OBSCN0.54853558
64KDR0.51730236
65BRSK20.51232524
66KIT0.50457730
67VRK10.49010126
68MAP3K20.48830806
69INSRR0.47968082
70MAP3K100.46320775
71MAPKAPK50.43229937
72DYRK30.42927841
73TIE10.41687070
74ATM0.39376876
75PDK10.39138107
76MELK0.38659273
77TESK20.38594230
78SCYL20.37664940
79WEE10.37438133
80MAP3K70.35118313
81STK110.34228934
82GRK70.32964323
83SGK10.30681727
84IKBKB0.30267455
85EGFR0.30227978
86CAMK2A0.29159571
87MAP3K120.28457790
88DAPK20.26212215
89PIK3CA0.25688339
90PRKCG0.25075304
91MAPK130.24255874
92MAPK30.24063922
93SYK0.23038256
94STK380.22168336
95PBK0.21959636
96GRK10.21399651
97PRKAA10.20816932
98MAPK10.20803141
99BCR0.20667322
100NEK90.20427748

Predicted pathways (KEGG)

RankGene SetZ-score
1Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.03783809
2Regulation of autophagy_Homo sapiens_hsa041402.90937587
3Fanconi anemia pathway_Homo sapiens_hsa034602.75739176
4Butanoate metabolism_Homo sapiens_hsa006502.64662234
5Homologous recombination_Homo sapiens_hsa034402.51048917
6Dorso-ventral axis formation_Homo sapiens_hsa043202.45757957
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.35064178
8Fatty acid degradation_Homo sapiens_hsa000712.29561814
9Propanoate metabolism_Homo sapiens_hsa006402.10016105
10ABC transporters_Homo sapiens_hsa020102.07290925
11Tryptophan metabolism_Homo sapiens_hsa003802.07075224
12Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.05944484
13Protein export_Homo sapiens_hsa030602.02709377
14Phototransduction_Homo sapiens_hsa047441.85821893
15Peroxisome_Homo sapiens_hsa041461.83113445
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.82272769
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.74172882
18beta-Alanine metabolism_Homo sapiens_hsa004101.70968841
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.58631137
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.55944896
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.51538028
22Histidine metabolism_Homo sapiens_hsa003401.48712469
23Taste transduction_Homo sapiens_hsa047421.45686539
24RNA degradation_Homo sapiens_hsa030181.45136540
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.45118459
26Linoleic acid metabolism_Homo sapiens_hsa005911.44467396
27Olfactory transduction_Homo sapiens_hsa047401.42881841
28SNARE interactions in vesicular transport_Homo sapiens_hsa041301.39155412
29Caffeine metabolism_Homo sapiens_hsa002321.39148893
30Fatty acid elongation_Homo sapiens_hsa000621.38896438
31Graft-versus-host disease_Homo sapiens_hsa053321.38612134
32Base excision repair_Homo sapiens_hsa034101.36202216
33N-Glycan biosynthesis_Homo sapiens_hsa005101.32109795
34Fatty acid metabolism_Homo sapiens_hsa012121.25301974
35Primary bile acid biosynthesis_Homo sapiens_hsa001201.24401545
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.15876680
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.14946649
38Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.14832780
39Chemical carcinogenesis_Homo sapiens_hsa052041.09985323
40Mismatch repair_Homo sapiens_hsa034301.08188224
41Nucleotide excision repair_Homo sapiens_hsa034201.06169932
42Glycerolipid metabolism_Homo sapiens_hsa005611.05999991
43Sphingolipid metabolism_Homo sapiens_hsa006001.04091558
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.01892195
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.00586948
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.99719008
47Purine metabolism_Homo sapiens_hsa002300.99410089
48Type I diabetes mellitus_Homo sapiens_hsa049400.93670476
49Pyruvate metabolism_Homo sapiens_hsa006200.93580055
50Arachidonic acid metabolism_Homo sapiens_hsa005900.91494426
51Non-homologous end-joining_Homo sapiens_hsa034500.91244617
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.90572685
53Intestinal immune network for IgA production_Homo sapiens_hsa046720.90261910
54Retinol metabolism_Homo sapiens_hsa008300.90060096
55Calcium signaling pathway_Homo sapiens_hsa040200.89119917
56Glycosaminoglycan degradation_Homo sapiens_hsa005310.87916032
57Lysine degradation_Homo sapiens_hsa003100.85416335
58Huntingtons disease_Homo sapiens_hsa050160.84954287
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82353823
60Tyrosine metabolism_Homo sapiens_hsa003500.80660500
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.79945248
62Nicotine addiction_Homo sapiens_hsa050330.79735823
63Renin-angiotensin system_Homo sapiens_hsa046140.73167201
64Glycerophospholipid metabolism_Homo sapiens_hsa005640.72833361
65Lysosome_Homo sapiens_hsa041420.71140221
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70487595
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.67984078
68Rheumatoid arthritis_Homo sapiens_hsa053230.67040509
69Metabolic pathways_Homo sapiens_hsa011000.66287403
70RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66221213
71Autoimmune thyroid disease_Homo sapiens_hsa053200.65903115
72Allograft rejection_Homo sapiens_hsa053300.62383186
73RNA polymerase_Homo sapiens_hsa030200.61821964
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60922797
75Oocyte meiosis_Homo sapiens_hsa041140.60510611
76Antigen processing and presentation_Homo sapiens_hsa046120.60429275
77Phenylalanine metabolism_Homo sapiens_hsa003600.59348919
78Basal transcription factors_Homo sapiens_hsa030220.58941128
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56556546
80Primary immunodeficiency_Homo sapiens_hsa053400.55697151
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54114848
82Ether lipid metabolism_Homo sapiens_hsa005650.53981723
83Asthma_Homo sapiens_hsa053100.53591669
84Fatty acid biosynthesis_Homo sapiens_hsa000610.52206050
85mTOR signaling pathway_Homo sapiens_hsa041500.51512869
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51453977
87Arginine and proline metabolism_Homo sapiens_hsa003300.50656181
88TGF-beta signaling pathway_Homo sapiens_hsa043500.50484858
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49982837
90DNA replication_Homo sapiens_hsa030300.45753721
91Nitrogen metabolism_Homo sapiens_hsa009100.43187848
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42460068
93Parkinsons disease_Homo sapiens_hsa050120.40659691
94Glutathione metabolism_Homo sapiens_hsa004800.38831043
95Ovarian steroidogenesis_Homo sapiens_hsa049130.38599600
96Selenocompound metabolism_Homo sapiens_hsa004500.36989618
97Morphine addiction_Homo sapiens_hsa050320.36687319
98Pyrimidine metabolism_Homo sapiens_hsa002400.35767947
99Inositol phosphate metabolism_Homo sapiens_hsa005620.34800684
100Serotonergic synapse_Homo sapiens_hsa047260.32522419

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