C1ORF100

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of MHC class I biosynthetic process (GO:0045343)9.79395254
2regulation of establishment of cell polarity (GO:2000114)9.69703160
3sex differentiation (GO:0007548)9.27185609
4regulation of interleukin-13 production (GO:0032656)8.62803239
5sterol catabolic process (GO:0016127)8.17983974
6cholesterol catabolic process (GO:0006707)8.17983974
7stress granule assembly (GO:0034063)8.03336086
8regulation of establishment or maintenance of cell polarity (GO:0032878)7.80070077
9regulation of interleukin-5 production (GO:0032674)7.05234646
10cerebellar Purkinje cell differentiation (GO:0021702)6.93163133
11alternative mRNA splicing, via spliceosome (GO:0000380)6.83246720
12ADP metabolic process (GO:0046031)6.70434035
13negative regulation of receptor-mediated endocytosis (GO:0048261)6.44425219
14positive regulation of vasculogenesis (GO:2001214)6.26558676
15centrosome duplication (GO:0051298)6.16150960
16tryptophan catabolic process (GO:0006569)5.67781695
17indole-containing compound catabolic process (GO:0042436)5.67781695
18indolalkylamine catabolic process (GO:0046218)5.67781695
19nucleoside diphosphate catabolic process (GO:0009134)5.62648174
20regulation of metalloenzyme activity (GO:0048552)5.58937324
21kynurenine metabolic process (GO:0070189)5.58747848
22seminiferous tubule development (GO:0072520)5.08211892
23negative regulation of endothelial cell apoptotic process (GO:2000352)5.03598382
24acrosome assembly (GO:0001675)5.02221729
25bile acid biosynthetic process (GO:0006699)4.87996673
26regulation of vasculogenesis (GO:2001212)4.81716988
27tryptophan metabolic process (GO:0006568)4.68179121
28lipid particle organization (GO:0034389)4.66457830
29sperm motility (GO:0030317)4.38714595
30regulation of triglyceride catabolic process (GO:0010896)4.20142824
31negative regulation of endothelial cell proliferation (GO:0001937)4.19006722
32positive regulation of heat generation (GO:0031652)4.14706789
33regulation of type 2 immune response (GO:0002828)4.11035132
34phosphatidylethanolamine biosynthetic process (GO:0006646)4.06407425
35detection of chemical stimulus involved in sensory perception of smell (GO:0050911)4.04347603
36one-carbon compound transport (GO:0019755)4.03928022
37regulation of action potential (GO:0098900)4.01274923
38purine nucleoside diphosphate metabolic process (GO:0009135)3.99291021
39purine ribonucleoside diphosphate metabolic process (GO:0009179)3.99291021
40protein autoprocessing (GO:0016540)3.98845676
41microtubule polymerization or depolymerization (GO:0031109)3.91483886
42phosphatidylethanolamine metabolic process (GO:0046337)3.87720955
43synaptic transmission, cholinergic (GO:0007271)3.85932264
44establishment of protein localization to Golgi (GO:0072600)3.71260109
45NAD biosynthetic process (GO:0009435)3.70461392
46negative regulation of T cell differentiation (GO:0045581)3.70166015
47estrogen biosynthetic process (GO:0006703)3.67951383
48negative regulation of mast cell activation (GO:0033004)3.67169226
49regulation of superoxide metabolic process (GO:0090322)3.67132067
50phospholipid translocation (GO:0045332)3.61782779
51lipid translocation (GO:0034204)3.61782779
52steroid catabolic process (GO:0006706)3.60336436
53histone H3-K4 trimethylation (GO:0080182)3.57917880
54L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.52701361
55amine catabolic process (GO:0009310)3.52011034
56cellular biogenic amine catabolic process (GO:0042402)3.52011034
57somite rostral/caudal axis specification (GO:0032525)3.48558728
58protein targeting to Golgi (GO:0000042)3.45730803
59regulation of sequestering of triglyceride (GO:0010889)3.42442332
60phosphatidylglycerol biosynthetic process (GO:0006655)3.40191312
61cellular ketone body metabolic process (GO:0046950)3.38857475
62indolalkylamine metabolic process (GO:0006586)3.33821577
63aromatic amino acid family catabolic process (GO:0009074)3.32469348
64cell differentiation in hindbrain (GO:0021533)3.32010339
65regulation of response to reactive oxygen species (GO:1901031)3.27702953
66negative regulation of endothelial cell migration (GO:0010596)3.23474790
67response to X-ray (GO:0010165)3.21833634
68multicellular organism reproduction (GO:0032504)3.21065323
69axonemal dynein complex assembly (GO:0070286)3.20204366
70regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.19915550
71regulation of receptor internalization (GO:0002090)3.16705311
72positive regulation of triglyceride biosynthetic process (GO:0010867)3.15496984
73male meiosis I (GO:0007141)3.13915678
74response to lipoprotein particle (GO:0055094)3.13249850
75regulation of heat generation (GO:0031650)3.13174449
76positive regulation of fatty acid beta-oxidation (GO:0032000)3.10312798
77retrograde transport, vesicle recycling within Golgi (GO:0000301)3.10076890
78detection of chemical stimulus involved in sensory perception (GO:0050907)3.08493059
79iron ion import (GO:0097286)3.04597782
80acrosome reaction (GO:0007340)3.03940100
81nicotinamide nucleotide biosynthetic process (GO:0019359)3.01102764
82pyridine nucleotide biosynthetic process (GO:0019363)3.01102764
83ribonucleoside diphosphate metabolic process (GO:0009185)2.95289480
84ketone body metabolic process (GO:1902224)2.94341056
85JAK-STAT cascade (GO:0007259)2.94288198
86androgen biosynthetic process (GO:0006702)2.92326054
87regulation of endothelial cell apoptotic process (GO:2000351)2.91278721
88actin cytoskeleton reorganization (GO:0031532)2.90731296
89sperm-egg recognition (GO:0035036)2.87144020
90regulation of ARF GTPase activity (GO:0032312)2.87139034
91dicarboxylic acid biosynthetic process (GO:0043650)2.85728870
92neuronal action potential propagation (GO:0019227)2.85644181
93central nervous system projection neuron axonogenesis (GO:0021952)2.83200505
94DNA replication checkpoint (GO:0000076)2.81140195
95regulation of histone H3-K9 methylation (GO:0051570)2.80266414
96negative regulation of reactive oxygen species metabolic process (GO:2000378)2.79999010
97regulation of memory T cell differentiation (GO:0043380)12.3762068
98cytoplasmic mRNA processing body assembly (GO:0033962)10.9367377
99negative regulation of multicellular organism growth (GO:0040015)10.9044876
100negative regulation of type 2 immune response (GO:0002829)10.3685647

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse6.29906022
2VDR_22108803_ChIP-Seq_LS180_Human4.50410518
3SALL1_21062744_ChIP-ChIP_HESCs_Human4.36142791
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.08371569
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.95841068
6TAF15_26573619_Chip-Seq_HEK293_Human2.99918211
7ER_23166858_ChIP-Seq_MCF-7_Human2.75191476
8CTBP2_25329375_ChIP-Seq_LNCAP_Human2.74827424
9EZH2_22144423_ChIP-Seq_EOC_Human2.33273586
10EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.31445485
11BCAT_22108803_ChIP-Seq_LS180_Human2.25929926
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.24675772
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.18057817
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.13895355
15VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.08555042
16IGF1R_20145208_ChIP-Seq_DFB_Human1.99886893
17GBX2_23144817_ChIP-Seq_PC3_Human1.97743967
18FUS_26573619_Chip-Seq_HEK293_Human1.96818115
19CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91043272
20* OCT1_27270436_Chip-Seq_PROSTATE_Human1.74106685
21DROSHA_22980978_ChIP-Seq_HELA_Human1.71306363
22UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.67583977
23ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.57567317
24ZNF274_21170338_ChIP-Seq_K562_Hela1.57526986
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.56381668
26IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.54866450
27CBP_20019798_ChIP-Seq_JUKART_Human1.54866450
28* TBL1_22424771_ChIP-Seq_293T_Human1.49341716
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.48095707
30TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.46722592
31OCT4_20526341_ChIP-Seq_ESCs_Human1.43815237
32* SMAD4_21741376_ChIP-Seq_EPCs_Human1.41001993
33ERA_21632823_ChIP-Seq_H3396_Human1.40716618
34CDX2_22108803_ChIP-Seq_LS180_Human1.39738068
35POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.34889552
36TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34889552
37* TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.33264407
38ETV2_25802403_ChIP-Seq_MESCs_Mouse1.32641809
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31468256
40AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29176093
41* STAT3_23295773_ChIP-Seq_U87_Human1.27315625
42KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.25691108
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25415171
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.23875387
45IRF1_19129219_ChIP-ChIP_H3396_Human1.23456539
46NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23129248
47* ETV1_20927104_ChIP-Seq_GIST48_Human1.22444753
48WDR5_24793694_ChIP-Seq_LNCAP_Human1.21376387
49* PHF8_20622853_ChIP-Seq_HELA_Human1.21274475
50* NFYB_21822215_ChIP-Seq_K562_Human1.20902285
51ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.20436509
52KDM2B_26808549_Chip-Seq_REH_Human1.19880155
53TAF2_19829295_ChIP-Seq_ESCs_Human1.17854890
54TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17777270
55TCF4_23295773_ChIP-Seq_U87_Human1.17091228
56* ARNT_22903824_ChIP-Seq_MCF-7_Human1.16997789
57* NFYA_21822215_ChIP-Seq_K562_Human1.16882054
58KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16356283
59LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15442765
60MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14833942
61NCOR_22424771_ChIP-Seq_293T_Human1.14433173
62* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14147903
63* CBX2_22325352_ChIP-Seq_293T-Rex_Human1.13349425
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12408497
65ESET_19884257_ChIP-Seq_ESCs_Mouse1.11284625
66TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11142407
67RUNX2_22187159_ChIP-Seq_PCA_Human1.10365951
68RAC3_21632823_ChIP-Seq_H3396_Human1.08992254
69* HNFA_21074721_ChIP-Seq_CACO-2_Human1.07719884
70MYC_19829295_ChIP-Seq_ESCs_Human1.06514817
71SMAD4_21799915_ChIP-Seq_A2780_Human1.05694160
72TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05270955
73PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.04624756
74MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03751739
75CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03017545
76* PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.02745237
77TP63_23658742_ChIP-Seq_EP156T_Human1.02590134
78* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01846412
79* RBPJ_21746931_ChIP-Seq_IB4_Human1.00788915
80* AR_25329375_ChIP-Seq_VCAP_Human1.00097529
81* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.98386478
82* TP53_18474530_ChIP-ChIP_U2OS_Human0.98351170
83CEBPB_22108803_ChIP-Seq_LS180_Human0.98252221
84ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.97762660
85PRDM14_20953172_ChIP-Seq_ESCs_Human0.97731450
86P300_19829295_ChIP-Seq_ESCs_Human0.97333079
87TDRD3_21172665_ChIP-Seq_MCF-7_Human0.96845002
88* FOXA1_25329375_ChIP-Seq_VCAP_Human0.96769301
89* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96769301
90MYB_26560356_Chip-Seq_TH2_Human0.94106431
91FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.93372828
92RXR_22108803_ChIP-Seq_LS180_Human0.93320881
93SMRT_27268052_Chip-Seq_Bcells_Human0.92912126
94* CJUN_26792858_Chip-Seq_BT549_Human0.92368537
95KLF4_19829295_ChIP-Seq_ESCs_Human0.90749140
96* NANOG_20526341_ChIP-Seq_ESCs_Human0.89415394
97PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.88218206
98TOP2B_26459242_ChIP-Seq_MCF-7_Human0.87828659
99NMYC_18555785_Chip-Seq_ESCs_Mouse0.87396763
100TAL1_26923725_Chip-Seq_HPCs_Mouse0.87301733

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003252_abnormal_bile_duct6.60581761
2MP0003011_delayed_dark_adaptation6.54367255
3MP0005410_abnormal_fertilization5.40945176
4MP0002736_abnormal_nociception_after4.13876245
5MP0001986_abnormal_taste_sensitivity3.75707287
6MP0000569_abnormal_digit_pigmentation3.50727785
7MP0001968_abnormal_touch/_nociception3.14248813
8MP0000371_diluted_coat_color2.94363054
9MP0003950_abnormal_plasma_membrane2.62946227
10MP0005253_abnormal_eye_physiology2.29445572
11MP0003718_maternal_effect2.11450161
12MP0001501_abnormal_sleep_pattern2.10233101
13MP0003646_muscle_fatigue2.00737562
14MP0005647_abnormal_sex_gland2.00487804
15MP0003172_abnormal_lysosome_physiology1.99840005
16MP0005083_abnormal_biliary_tract1.98651584
17MP0009840_abnormal_foam_cell1.93574244
18MP0005310_abnormal_salivary_gland1.93457581
19MP0004264_abnormal_extraembryonic_tissu1.88382759
20MP0001348_abnormal_lacrimal_gland1.78047722
21MP0009745_abnormal_behavioral_response1.75927676
22MP0003698_abnormal_male_reproductive1.75375468
23MP0005334_abnormal_fat_pad1.58028326
24MP0003878_abnormal_ear_physiology1.57928515
25MP0005377_hearing/vestibular/ear_phenot1.57928515
26MP0006035_abnormal_mitochondrial_morpho1.54739880
27MP0002138_abnormal_hepatobiliary_system1.52398473
28MP0003186_abnormal_redox_activity1.49511546
29MP0005646_abnormal_pituitary_gland1.45650588
30MP0002161_abnormal_fertility/fecundity1.40923924
31MP0001929_abnormal_gametogenesis1.38592033
32MP0005551_abnormal_eye_electrophysiolog1.38510243
33MP0009697_abnormal_copulation1.35766484
34MP0004233_abnormal_muscle_weight1.34511097
35MP0010386_abnormal_urinary_bladder1.33123729
36MP0002837_dystrophic_cardiac_calcinosis1.32194192
37MP0001486_abnormal_startle_reflex1.28747679
38MP0004130_abnormal_muscle_cell1.28249254
39MP0006072_abnormal_retinal_apoptosis1.23044134
40MP0003195_calcinosis1.22561843
41MP0003137_abnormal_impulse_conducting1.20561679
42MP0001666_abnormal_nutrient_absorption1.20109198
43MP0000653_abnormal_sex_gland1.15945543
44MP0002282_abnormal_trachea_morphology1.15351071
45MP0002693_abnormal_pancreas_physiology1.14591483
46MP0009046_muscle_twitch1.14369772
47MP0004147_increased_porphyrin_level1.13563572
48MP0005636_abnormal_mineral_homeostasis1.13055818
49MP0002118_abnormal_lipid_homeostasis1.07593340
50MP0002210_abnormal_sex_determination1.05538297
51MP0001145_abnormal_male_reproductive1.01776747
52MP0002132_abnormal_respiratory_system1.01121465
53MP0006036_abnormal_mitochondrial_physio1.00952393
54MP0002638_abnormal_pupillary_reflex1.00930115
55MP0000678_abnormal_parathyroid_gland1.00770094
56MP0001764_abnormal_homeostasis0.98825240
57MP0002139_abnormal_hepatobiliary_system0.95630389
58MP0002075_abnormal_coat/hair_pigmentati0.93601828
59MP0008961_abnormal_basal_metabolism0.90662437
60MP0000427_abnormal_hair_cycle0.87278131
61MP0005670_abnormal_white_adipose0.85252894
62MP0005171_absent_coat_pigmentation0.85051355
63MP0002064_seizures0.84614491
64MP0001873_stomach_inflammation0.84023241
65MP0004742_abnormal_vestibular_system0.82499504
66MP0005451_abnormal_body_composition0.82135834
67MP0003936_abnormal_reproductive_system0.81671912
68MP0000609_abnormal_liver_physiology0.81048933
69MP0009115_abnormal_fat_cell0.79472538
70MP0005395_other_phenotype0.77869472
71MP0005174_abnormal_tail_pigmentation0.76754869
72MP0002733_abnormal_thermal_nociception0.75687919
73MP0002272_abnormal_nervous_system0.75442901
74MP0008770_decreased_survivor_rate0.72620691
75MP0002229_neurodegeneration0.70524960
76MP0009384_cardiac_valve_regurgitation0.70451920
77MP0001730_embryonic_growth_arrest0.70054954
78MP0003935_abnormal_craniofacial_develop0.69829494
79MP0005391_vision/eye_phenotype0.68908880
80MP0005408_hypopigmentation0.67986341
81MP0003119_abnormal_digestive_system0.65280698
82MP0004510_myositis0.64252020
83MP0000749_muscle_degeneration0.63160586
84MP0008004_abnormal_stomach_pH0.59040428
85MP0001944_abnormal_pancreas_morphology0.56648068
86MP0005360_urolithiasis0.56515638
87MP0003699_abnormal_female_reproductive0.56389084
88MP0002234_abnormal_pharynx_morphology0.55155176
89MP0001963_abnormal_hearing_physiology0.53409729
90MP0000685_abnormal_immune_system0.53268983
91MP0005085_abnormal_gallbladder_physiolo0.52352584
92MP0000470_abnormal_stomach_morphology0.52052883
93MP0005167_abnormal_blood-brain_barrier0.51897444
94MP0001186_pigmentation_phenotype0.51216401
95MP0002067_abnormal_sensory_capabilities0.46961799
96MP0003633_abnormal_nervous_system0.46296045
97MP0004043_abnormal_pH_regulation0.46267382
98MP0001664_abnormal_digestion0.46246931
99MP0000015_abnormal_ear_pigmentation0.46062000
100MP0004381_abnormal_hair_follicle0.45602135

Predicted human phenotypes

RankGene SetZ-score
1Action tremor (HP:0002345)9.56544162
2Progressive cerebellar ataxia (HP:0002073)8.82395240
3Prostate neoplasm (HP:0100787)7.46991489
4Abnormality of the hepatic vasculature (HP:0006707)6.11595526
5Postural instability (HP:0002172)6.10503852
6Slow saccadic eye movements (HP:0000514)5.87832696
7Absence seizures (HP:0002121)5.72456882
8Pendular nystagmus (HP:0012043)5.38443080
9Urinary bladder sphincter dysfunction (HP:0002839)5.24952990
10Gaze-evoked nystagmus (HP:0000640)5.23812040
11Severe visual impairment (HP:0001141)5.16507703
12Postural tremor (HP:0002174)4.89567869
13Dysdiadochokinesis (HP:0002075)4.46230504
14Limb ataxia (HP:0002070)4.45008180
15Impaired vibratory sensation (HP:0002495)4.40503032
16Dialeptic seizures (HP:0011146)4.30418730
17Hypochromic microcytic anemia (HP:0004840)3.94244737
18Abnormality of macular pigmentation (HP:0008002)3.91282323
19Abnormality of the prostate (HP:0008775)3.89840203
20Focal seizures (HP:0007359)3.80926334
21Impaired smooth pursuit (HP:0007772)3.75609217
22Impaired proprioception (HP:0010831)3.58289606
23Dynein arm defect of respiratory motile cilia (HP:0012255)3.41184445
24Absent/shortened dynein arms (HP:0200106)3.41184445
25Abnormal respiratory motile cilium physiology (HP:0012261)2.98733304
26Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.98528881
27Abnormality of saccadic eye movements (HP:0000570)2.77160695
28Postnatal microcephaly (HP:0005484)2.71110050
29Abnormality of male internal genitalia (HP:0000022)2.67704076
30Hyperthyroidism (HP:0000836)2.65542329
31Abnormal ciliary motility (HP:0012262)2.65434010
32Atonic seizures (HP:0010819)2.63549918
33Tinnitus (HP:0000360)2.60867585
34Abnormality of ocular smooth pursuit (HP:0000617)2.58405613
35Portal hypertension (HP:0001409)2.51507353
36Bradykinesia (HP:0002067)2.43209653
37Abnormality of vision evoked potentials (HP:0000649)2.40162283
38Truncus arteriosus (HP:0001660)2.36152932
39Hypochromic anemia (HP:0001931)2.35237706
40Areflexia of lower limbs (HP:0002522)2.34059071
41Oculomotor apraxia (HP:0000657)2.24456843
42Increased corneal curvature (HP:0100692)2.23697702
43Keratoconus (HP:0000563)2.23697702
44Chorioretinal atrophy (HP:0000533)2.22791918
45Focal motor seizures (HP:0011153)2.22107298
46Rib fusion (HP:0000902)2.19733825
47Vitreoretinal degeneration (HP:0000655)2.18215039
48Chronic hepatic failure (HP:0100626)2.17026269
49Severe Myopia (HP:0011003)2.13500816
50Clumsiness (HP:0002312)2.07245103
51Gingival bleeding (HP:0000225)2.03219009
52Abnormal respiratory motile cilium morphology (HP:0005938)2.01468932
53Abnormal respiratory epithelium morphology (HP:0012253)2.01468932
54Retinitis pigmentosa (HP:0000510)2.00924491
55Genetic anticipation (HP:0003743)10.9412633
56Dysmetric saccades (HP:0000641)10.6676432
57Biliary tract neoplasm (HP:0100574)1.98020549
58Male infertility (HP:0003251)1.93341911
59Infertility (HP:0000789)1.85491129
60Febrile seizures (HP:0002373)1.82403675
61Amaurosis fugax (HP:0100576)1.82121926
62Arterial thrombosis (HP:0004420)1.81813186
63Bilateral microphthalmos (HP:0007633)1.81501203
64Hypophosphatemic rickets (HP:0004912)1.79500667
65Congenital sensorineural hearing impairment (HP:0008527)1.78903800
66Protruding tongue (HP:0010808)1.77991094
67Bony spicule pigmentary retinopathy (HP:0007737)1.76785689
68Hyperventilation (HP:0002883)1.72304977
69Attenuation of retinal blood vessels (HP:0007843)1.71467790
70Chromosomal breakage induced by crosslinking agents (HP:0003221)1.71426055
71Chromsome breakage (HP:0040012)1.70876981
72Loss of speech (HP:0002371)1.68752346
73Rhinitis (HP:0012384)1.66663598
74Anomalous pulmonary venous return (HP:0010772)1.63796163
75Fasciculations (HP:0002380)1.61255405
76Ileus (HP:0002595)1.61188560
77Dysmetria (HP:0001310)1.58335373
78Tubulointerstitial nephritis (HP:0001970)1.57728349
79Proximal tubulopathy (HP:0000114)1.55516379
80Aplasia/Hypoplasia of the earlobes (HP:0009906)1.55171909
81Progressive hearing impairment (HP:0001730)1.54839825
82Cortical visual impairment (HP:0100704)1.53551558
83Decreased muscle mass (HP:0003199)1.50714457
84Seborrheic dermatitis (HP:0001051)1.50563823
85Abnormal EKG (HP:0003115)1.49340100
86Hypertensive crisis (HP:0100735)1.47874892
87Aplasia/Hypoplasia of the thymus (HP:0010515)1.46521360
88Pancreatic cysts (HP:0001737)1.46131709
89Progressive sensorineural hearing impairment (HP:0000408)1.45347914
90Horizontal nystagmus (HP:0000666)1.44970334
91Autoimmune thrombocytopenia (HP:0001973)1.43864601
92Macular degeneration (HP:0000608)1.42677969
93Rigidity (HP:0002063)1.40897483
94Bowel incontinence (HP:0002607)1.40543210
95Macroglossia (HP:0000158)1.39098850
96Hypoproteinemia (HP:0003075)1.39095518
97Atelectasis (HP:0100750)1.39093257
98Obstructive lung disease (HP:0006536)1.39015509
99Chronic obstructive pulmonary disease (HP:0006510)1.39015509
100Generalized aminoaciduria (HP:0002909)1.38370285

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OXSR15.57276518
2FRK5.39682502
3PINK12.88353611
4PLK42.79401979
5BRD42.44557694
6MAP3K72.39538882
7TNK22.29275821
8ACVR1B2.17706220
9CDK1910.9862845
10CDK121.97535176
11GRK11.96071630
12BMPR1B1.91809181
13TXK1.62264030
14MKNK21.60735387
15INSRR1.56354467
16STK381.52470073
17ALK1.31992803
18ZAK1.31569909
19RPS6KB21.24648086
20STK31.11600405
21ADRBK21.10419105
22MARK31.08634329
23PDPK11.08474026
24PDK11.04357214
25MKNK10.92481467
26FER0.86037308
27PLK20.84068040
28PIK3CG0.82794157
29TAOK30.79709172
30JAK20.78368132
31TGFBR10.76503341
32MAP3K90.75697133
33RIPK40.74029382
34KSR20.73333024
35BCR0.72362660
36MTOR0.67499528
37STK38L0.67481536
38STK110.66062035
39TYRO30.61505425
40NTRK30.60735220
41CHEK10.50122102
42PRKAA20.49438628
43MAPKAPK50.49005949
44PDK20.47451325
45CHEK20.47013631
46WNK10.44774948
47TIE10.43619755
48BLK0.43512595
49CDK90.42955142
50MAP4K20.42854754
51PBK0.40678642
52WNK40.40509599
53PTK2B0.38984596
54MAP2K10.38886790
55MST1R0.36991015
56BRSK20.36055715
57DDR20.35051718
58NEK60.33928079
59JAK30.32169725
60CDK150.31554798
61PRKG10.31049667
62EEF2K0.29815492
63TRPM70.29264128
64CDK140.28480715
65CDK11A0.27650014
66MAP3K20.27325891
67CDK180.26972618
68CDK40.26859340
69MAPK10.25450038
70PAK10.25353303
71MAPK110.24630641
72NEK20.24009475
73MATK0.23605679
74RPS6KA50.23079912
75PRKG20.22411097
76SIK20.22357061
77PRKAA10.19762526
78CDK50.19384696
79BMX0.19130204
80MAP3K80.18675352
81MAP2K60.17336751
82AKT10.17289313
83SGK10.16421839
84CSNK1A10.16345514
85MAPK150.16149796
86TTK0.15889150
87BMPR20.15759127
88BTK0.15440110
89CLK10.13633148
90CDK10.13494550
91IRAK30.13137285
92TEC0.12656431
93RPS6KA10.11810718
94GSK3B0.10277296
95STK40.10176439
96FGR0.09936371
97CSNK1A1L0.09439990
98GRK70.09411782
99MARK20.09324595
100MAP3K40.08479916

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001208.84723061
2Fatty acid biosynthesis_Homo sapiens_hsa000613.86235712
3Olfactory transduction_Homo sapiens_hsa047403.51450855
4Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.09506082
5Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.99149164
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.35864955
7Butanoate metabolism_Homo sapiens_hsa006502.30308852
8Steroid hormone biosynthesis_Homo sapiens_hsa001402.11824296
9RNA polymerase_Homo sapiens_hsa030202.08748132
10Tryptophan metabolism_Homo sapiens_hsa003802.02171451
11Retinol metabolism_Homo sapiens_hsa008301.96249185
12Caffeine metabolism_Homo sapiens_hsa002321.86290895
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.81627440
14Propanoate metabolism_Homo sapiens_hsa006401.70320745
15Ether lipid metabolism_Homo sapiens_hsa005651.51594532
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.44892500
17PPAR signaling pathway_Homo sapiens_hsa033201.39419924
18Cysteine and methionine metabolism_Homo sapiens_hsa002701.36452392
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.32211626
20Glycosaminoglycan degradation_Homo sapiens_hsa005311.19573254
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.16268633
22Drug metabolism - other enzymes_Homo sapiens_hsa009831.13942198
23Nitrogen metabolism_Homo sapiens_hsa009101.13448107
24Taste transduction_Homo sapiens_hsa047421.12711591
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.08565105
26ABC transporters_Homo sapiens_hsa020101.03530260
27Jak-STAT signaling pathway_Homo sapiens_hsa046300.98474862
28Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.98043775
29Pyruvate metabolism_Homo sapiens_hsa006200.96024095
30Fatty acid degradation_Homo sapiens_hsa000710.88391711
31Renin-angiotensin system_Homo sapiens_hsa046140.88279143
32Dorso-ventral axis formation_Homo sapiens_hsa043200.85900536
33Pentose and glucuronate interconversions_Homo sapiens_hsa000400.84883399
34Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.81136284
35Purine metabolism_Homo sapiens_hsa002300.80888853
36Chemical carcinogenesis_Homo sapiens_hsa052040.79868962
37Fatty acid metabolism_Homo sapiens_hsa012120.79237321
38Type II diabetes mellitus_Homo sapiens_hsa049300.76020925
39Linoleic acid metabolism_Homo sapiens_hsa005910.75519691
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.74063529
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72226025
42Glycerophospholipid metabolism_Homo sapiens_hsa005640.72177596
43cAMP signaling pathway_Homo sapiens_hsa040240.68810047
44Glycerolipid metabolism_Homo sapiens_hsa005610.68506911
45Gastric acid secretion_Homo sapiens_hsa049710.68175976
46Influenza A_Homo sapiens_hsa051640.67473432
47Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65222411
48Salivary secretion_Homo sapiens_hsa049700.64525194
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.64300007
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60481645
51Fanconi anemia pathway_Homo sapiens_hsa034600.59831197
52Circadian rhythm_Homo sapiens_hsa047100.58874390
53Pyrimidine metabolism_Homo sapiens_hsa002400.53428723
54Hepatitis C_Homo sapiens_hsa051600.50505585
55Herpes simplex infection_Homo sapiens_hsa051680.49417418
56Sphingolipid metabolism_Homo sapiens_hsa006000.48733986
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46636101
58Phototransduction_Homo sapiens_hsa047440.46389930
59Adipocytokine signaling pathway_Homo sapiens_hsa049200.44290174
60N-Glycan biosynthesis_Homo sapiens_hsa005100.43162610
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43150148
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40415400
63Lysosome_Homo sapiens_hsa041420.39499398
64Starch and sucrose metabolism_Homo sapiens_hsa005000.39092981
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38039518
66Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37778675
67Glutathione metabolism_Homo sapiens_hsa004800.35862086
68Insulin resistance_Homo sapiens_hsa049310.35062580
69Hedgehog signaling pathway_Homo sapiens_hsa043400.34971084
70Glutamatergic synapse_Homo sapiens_hsa047240.34149904
71Mineral absorption_Homo sapiens_hsa049780.33715079
72beta-Alanine metabolism_Homo sapiens_hsa004100.33232702
73Rap1 signaling pathway_Homo sapiens_hsa040150.33209924
74Gap junction_Homo sapiens_hsa045400.33203788
75African trypanosomiasis_Homo sapiens_hsa051430.32635844
76Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.32033341
77Melanoma_Homo sapiens_hsa052180.31331982
78Choline metabolism in cancer_Homo sapiens_hsa052310.30371640
79Metabolic pathways_Homo sapiens_hsa011000.29930558
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.29775449
81Renal cell carcinoma_Homo sapiens_hsa052110.29576361
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.28471516
83One carbon pool by folate_Homo sapiens_hsa006700.28019503
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27072715
85ErbB signaling pathway_Homo sapiens_hsa040120.26742930
86Calcium signaling pathway_Homo sapiens_hsa040200.26520680
87Homologous recombination_Homo sapiens_hsa034400.25979043
88Morphine addiction_Homo sapiens_hsa050320.25855850
89Lysine degradation_Homo sapiens_hsa003100.24931702
90Peroxisome_Homo sapiens_hsa041460.24575987
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.23923666
92Long-term depression_Homo sapiens_hsa047300.23766748
93MAPK signaling pathway_Homo sapiens_hsa040100.23459096
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.23009256
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.22811854
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.21334049
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.21316312
98Nicotine addiction_Homo sapiens_hsa050330.18205072
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.18112159
100Other glycan degradation_Homo sapiens_hsa005110.17514508

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