C1DP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organism reproduction (GO:0032504)6.36824308
2oocyte development (GO:0048599)6.32482613
3male meiosis I (GO:0007141)6.02830229
4regulation of acrosome reaction (GO:0060046)5.82697280
5regulation of exit from mitosis (GO:0007096)5.53498784
6meiosis I (GO:0007127)5.06462745
7regulation of RIG-I signaling pathway (GO:0039535)4.99155734
8transcription from mitochondrial promoter (GO:0006390)4.97012367
9positive regulation of uterine smooth muscle contraction (GO:0070474)4.92147439
10histone lysine demethylation (GO:0070076)4.83191109
11regulation of cytokine production involved in inflammatory response (GO:1900015)4.81439326
12synaptonemal complex organization (GO:0070193)4.81317124
13protein K6-linked ubiquitination (GO:0085020)4.77883696
14positive regulation of catecholamine secretion (GO:0033605)4.77726125
15N-terminal protein amino acid acetylation (GO:0006474)4.66685029
16histone demethylation (GO:0016577)4.62763849
17synaptonemal complex assembly (GO:0007130)4.59600696
18regulation of alternative mRNA splicing, via spliceosome (GO:0000381)4.54641126
19regulation of female receptivity (GO:0045924)4.50216766
20response to UV-C (GO:0010225)4.48563156
21positive regulation of meiosis (GO:0045836)4.38480008
22regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)4.34012483
23positive regulation of meiotic cell cycle (GO:0051446)4.31783043
24reproduction (GO:0000003)4.26552524
25male meiosis (GO:0007140)4.22252863
26gonadal mesoderm development (GO:0007506)4.16580512
27protein demethylation (GO:0006482)4.16469886
28protein dealkylation (GO:0008214)4.16469886
29single fertilization (GO:0007338)4.11742846
30binding of sperm to zona pellucida (GO:0007339)4.05648152
31regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.87602434
32female mating behavior (GO:0060180)3.84518352
33maturation of SSU-rRNA (GO:0030490)3.74264142
34regulation of uterine smooth muscle contraction (GO:0070472)3.71070951
35acrosome reaction (GO:0007340)3.70832832
36aggressive behavior (GO:0002118)3.67986137
37protein kinase C signaling (GO:0070528)3.59488998
38autophagic vacuole assembly (GO:0000045)3.57549305
39drinking behavior (GO:0042756)3.56565443
40positive regulation of digestive system process (GO:0060456)3.48288516
41motile cilium assembly (GO:0044458)3.45816195
42negative regulation of Ras GTPase activity (GO:0034261)3.45545027
43negative regulation of reproductive process (GO:2000242)3.36881292
44mitochondrial RNA metabolic process (GO:0000959)3.35034128
45positive regulation of prostaglandin secretion (GO:0032308)3.28760846
46mitotic metaphase plate congression (GO:0007080)3.27563296
47rRNA modification (GO:0000154)3.25468449
48regulation of DNA methylation (GO:0044030)3.25219942
49regulation of penile erection (GO:0060405)3.23702967
50regulation of female gonad development (GO:2000194)3.22464207
51positive regulation of humoral immune response (GO:0002922)3.19822527
52fertilization (GO:0009566)3.19220171
53sperm-egg recognition (GO:0035036)3.17082016
54meiotic cell cycle (GO:0051321)3.16246047
55hyperosmotic salinity response (GO:0042538)3.14501772
56negative regulation of digestive system process (GO:0060457)3.13679828
57meiotic cell cycle process (GO:1903046)3.12527811
58piRNA metabolic process (GO:0034587)3.10039090
59skeletal muscle tissue regeneration (GO:0043403)3.05957065
60regulation of mRNA splicing, via spliceosome (GO:0048024)3.05880991
61intestinal epithelial cell development (GO:0060576)3.05302633
62chromosome organization involved in meiosis (GO:0070192)3.05162640
63sleep (GO:0030431)3.04309945
64regulation of prostaglandin secretion (GO:0032306)3.00838129
65negative regulation of retinoic acid receptor signaling pathway (GO:0048387)25.1000446
66regulation of retinoic acid receptor signaling pathway (GO:0048385)21.0698055
67positive regulation of protein homooligomerization (GO:0032464)2.99578254
68chaperone-mediated protein transport (GO:0072321)2.93139960
69positive regulation of histone H3-K4 methylation (GO:0051571)2.84298704
70RNA localization (GO:0006403)2.83857527
71attachment of spindle microtubules to kinetochore (GO:0008608)2.80483399
72centriole assembly (GO:0098534)2.79382916
73positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.78410332
74striated muscle atrophy (GO:0014891)2.76852377
75regulation of meiosis (GO:0040020)2.76030391
76ventricular cardiac muscle cell development (GO:0055015)2.72047877
77positive regulation of reproductive process (GO:2000243)2.71301282
78regulation of double-strand break repair via homologous recombination (GO:0010569)2.70610649
79N-terminal protein amino acid modification (GO:0031365)2.69012791
80meiotic nuclear division (GO:0007126)2.68831598
81regulation of helicase activity (GO:0051095)2.68083866
82regulation of mRNA processing (GO:0050684)2.68026826
83ribosomal small subunit biogenesis (GO:0042274)2.67650820
84calcium ion-dependent exocytosis (GO:0017156)2.66946052
85regulation of RNA splicing (GO:0043484)2.64637119
86transcription elongation from RNA polymerase III promoter (GO:0006385)2.64524931
87termination of RNA polymerase III transcription (GO:0006386)2.64524931
88maternal behavior (GO:0042711)2.60873362
89muscle atrophy (GO:0014889)2.60525484
90negative regulation of mRNA processing (GO:0050686)2.58935781
91regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.56590355
92rRNA methylation (GO:0031167)2.55815901
93cell-cell recognition (GO:0009988)2.53168049
94protein K48-linked deubiquitination (GO:0071108)2.52119274
95poly(A)+ mRNA export from nucleus (GO:0016973)2.52083312
96DNA replication-dependent nucleosome assembly (GO:0006335)2.42771256
97DNA replication-dependent nucleosome organization (GO:0034723)2.42771256
98regulation of G0 to G1 transition (GO:0070316)2.41402582
99metaphase plate congression (GO:0051310)2.40384105
100histone H3-K9 demethylation (GO:0033169)12.9184024

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse8.00363390
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.76454643
3EZH2_22144423_ChIP-Seq_EOC_Human4.29437247
4NOTCH1_21737748_ChIP-Seq_TLL_Human3.87853290
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.35320382
6VDR_22108803_ChIP-Seq_LS180_Human3.34093666
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.01577751
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.01531240
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.00318416
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.72206715
11E2F7_22180533_ChIP-Seq_HELA_Human2.67368903
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.59697378
13KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.58961151
14KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.58961151
15KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.58961151
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.44670559
17TP63_19390658_ChIP-ChIP_HaCaT_Human2.40749038
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.33631436
19ZNF274_21170338_ChIP-Seq_K562_Hela2.26182006
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.24873113
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.23905701
22E2F4_17652178_ChIP-ChIP_JURKAT_Human2.20027750
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.14780672
24AR_21909140_ChIP-Seq_LNCAP_Human2.09189476
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.00696384
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.96028753
27MYC_18940864_ChIP-ChIP_HL60_Human1.94492775
28IRF1_19129219_ChIP-ChIP_H3396_Human1.83105267
29JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.79573569
30AUTS2_25519132_ChIP-Seq_293T-REX_Human1.77874555
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.77587221
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.73007497
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.72975875
34TTF2_22483619_ChIP-Seq_HELA_Human1.72239936
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.66800487
36FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.64028564
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.57253668
38MYC_18555785_ChIP-Seq_MESCs_Mouse1.49149658
39CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.44392421
40ELF1_17652178_ChIP-ChIP_JURKAT_Human1.42272902
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42272062
42CBP_21632823_ChIP-Seq_H3396_Human1.39310109
43GBX2_23144817_ChIP-Seq_PC3_Human1.39292267
44VDR_23849224_ChIP-Seq_CD4+_Human1.37711039
45STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.35597931
46NCOR_22424771_ChIP-Seq_293T_Human1.33603511
47RNF2_27304074_Chip-Seq_NSC_Mouse1.32946832
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.28906479
49TP53_22573176_ChIP-Seq_HFKS_Human1.28818513
50POU5F1_16153702_ChIP-ChIP_HESCs_Human1.27126494
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26870907
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.26644808
53IGF1R_20145208_ChIP-Seq_DFB_Human1.26145062
54PRDM14_20953172_ChIP-Seq_ESCs_Human1.23405123
55ESR1_15608294_ChIP-ChIP_MCF-7_Human1.23370495
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21612404
57FOXP3_21729870_ChIP-Seq_TREG_Human1.17719568
58TCF4_23295773_ChIP-Seq_U87_Human1.15446963
59THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12917626
60SMAD4_21799915_ChIP-Seq_A2780_Human1.12163335
61RAC3_21632823_ChIP-Seq_H3396_Human1.11317245
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.10573056
63TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.10075811
64MYC_19079543_ChIP-ChIP_MESCs_Mouse1.09265229
65LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09174570
66KAP1_22055183_ChIP-Seq_ESCs_Mouse1.06887924
67MYC_18358816_ChIP-ChIP_MESCs_Mouse1.06037451
68GATA3_26560356_Chip-Seq_TH1_Human1.05735413
69STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.04523497
70FLI1_27457419_Chip-Seq_LIVER_Mouse1.03552244
71GABP_19822575_ChIP-Seq_HepG2_Human0.99939379
72TAF15_26573619_Chip-Seq_HEK293_Human0.99922983
73NELFA_20434984_ChIP-Seq_ESCs_Mouse0.95374236
74CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.95219348
75ZFP57_27257070_Chip-Seq_ESCs_Mouse0.95000729
76HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.94456754
77P300_19829295_ChIP-Seq_ESCs_Human0.93996206
78KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93839912
79MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92609894
80BCAT_22108803_ChIP-Seq_LS180_Human0.91583214
81EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.91037778
82PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.90961838
83CTBP1_25329375_ChIP-Seq_LNCAP_Human0.90871178
84STAT3_23295773_ChIP-Seq_U87_Human0.89708362
85ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.87793794
86TBL1_22424771_ChIP-Seq_293T_Human0.86569842
87FOXH1_21741376_ChIP-Seq_EPCs_Human0.86255634
88SMAD3_21741376_ChIP-Seq_HESCs_Human0.86217121
89CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.85043377
90MYC_19030024_ChIP-ChIP_MESCs_Mouse0.84167536
91PADI4_21655091_ChIP-ChIP_MCF-7_Human0.83610263
92SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.83430015
93GATA1_26923725_Chip-Seq_HPCs_Mouse0.83217939
94TP53_20018659_ChIP-ChIP_R1E_Mouse0.83200196
95GF1_26923725_Chip-Seq_HPCs_Mouse0.82285789
96TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.81743195
97KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.80963703
98TCF4_22108803_ChIP-Seq_LS180_Human0.80780727
99SMAD4_21741376_ChIP-Seq_EPCs_Human0.80066285
100ELK1_22589737_ChIP-Seq_MCF10A_Human0.79776627

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode5.59646400
2MP0001986_abnormal_taste_sensitivity4.32299313
3MP0009379_abnormal_foot_pigmentation4.28022477
4MP0005423_abnormal_somatic_nervous4.16153129
5MP0003693_abnormal_embryo_hatching3.65073282
6MP0003283_abnormal_digestive_organ3.44672339
7MP0002160_abnormal_reproductive_system3.32843100
8MP0003950_abnormal_plasma_membrane3.05766377
9MP0000678_abnormal_parathyroid_gland3.03410470
10MP0003136_yellow_coat_color2.99279098
11MP0009840_abnormal_foam_cell2.68817813
12MP0005410_abnormal_fertilization2.64792889
13MP0003718_maternal_effect2.59704055
14MP0001929_abnormal_gametogenesis2.44869844
15MP0008058_abnormal_DNA_repair2.41512705
16MP0002210_abnormal_sex_determination2.23429271
17MP0000427_abnormal_hair_cycle2.22822167
18MP0005360_urolithiasis2.18830308
19MP0010094_abnormal_chromosome_stability2.11749892
20MP0006276_abnormal_autonomic_nervous2.07662383
21MP0010307_abnormal_tumor_latency2.06103571
22MP0003077_abnormal_cell_cycle1.89369299
23MP0005389_reproductive_system_phenotype1.85910503
24MP0003699_abnormal_female_reproductive1.83196674
25MP0003111_abnormal_nucleus_morphology1.79718213
26MP0001502_abnormal_circadian_rhythm1.76406324
27MP0001666_abnormal_nutrient_absorption1.76363505
28MP0005647_abnormal_sex_gland1.73955330
29MP0008877_abnormal_DNA_methylation1.72088178
30MP0002127_abnormal_cardiovascular_syste1.66736269
31MP0000372_irregular_coat_pigmentation1.64074051
32MP0003646_muscle_fatigue1.55795395
33MP0005220_abnormal_exocrine_pancreas1.55648308
34MP0003938_abnormal_ear_development1.54938168
35MP0000653_abnormal_sex_gland1.53167605
36MP0002277_abnormal_respiratory_mucosa1.49842783
37MP0000049_abnormal_middle_ear1.48895187
38MP0003119_abnormal_digestive_system1.48713063
39MP0004957_abnormal_blastocyst_morpholog1.47347075
40MP0002751_abnormal_autonomic_nervous1.43883566
41MP0005646_abnormal_pituitary_gland1.42593424
42MP0003698_abnormal_male_reproductive1.34113955
43MP0002161_abnormal_fertility/fecundity1.25990937
44MP0001119_abnormal_female_reproductive1.25299714
45MP0003866_abnormal_defecation1.24118360
46MP0001145_abnormal_male_reproductive1.22834004
47MP0001664_abnormal_digestion1.21490358
48MP0001730_embryonic_growth_arrest1.20470686
49MP0003890_abnormal_embryonic-extraembry1.12076002
50MP0003936_abnormal_reproductive_system1.10747187
51MP0000350_abnormal_cell_proliferation1.07308540
52MP0003868_abnormal_feces_composition1.05640942
53MP0008260_abnormal_autophagy1.05566094
54MP0001881_abnormal_mammary_gland1.05198872
55MP0002163_abnormal_gland_morphology0.99955099
56MP0000462_abnormal_digestive_system0.98486540
57MP0000631_abnormal_neuroendocrine_gland0.90659960
58MP0001440_abnormal_grooming_behavior0.90626954
59MP0005394_taste/olfaction_phenotype0.89323465
60MP0005499_abnormal_olfactory_system0.89323465
61MP0010368_abnormal_lymphatic_system0.88146151
62MP0003121_genomic_imprinting0.83577524
63MP0010030_abnormal_orbit_morphology0.81848505
64MP0004233_abnormal_muscle_weight0.81489975
65MP0000470_abnormal_stomach_morphology0.78760244
66MP0006036_abnormal_mitochondrial_physio0.78722697
67MP0001286_abnormal_eye_development0.78350272
68MP0003183_abnormal_peptide_metabolism0.78191317
69MP0008932_abnormal_embryonic_tissue0.77914988
70MP0002102_abnormal_ear_morphology0.76035135
71MP0002090_abnormal_vision0.74190797
72MP0001672_abnormal_embryogenesis/_devel0.73798467
73MP0005380_embryogenesis_phenotype0.73798467
74MP0002095_abnormal_skin_pigmentation0.73549095
75MP0002396_abnormal_hematopoietic_system0.69835779
76MP0002269_muscular_atrophy0.68770596
77MP0003879_abnormal_hair_cell0.67027267
78MP0003880_abnormal_central_pattern0.66089815
79MP0006072_abnormal_retinal_apoptosis0.66013275
80MP0003786_premature_aging0.65390070
81MP0002085_abnormal_embryonic_tissue0.64854439
82MP0000627_abnormal_mammary_gland0.64426406
83MP0004215_abnormal_myocardial_fiber0.63448173
84MP0004019_abnormal_vitamin_homeostasis0.63086043
85MP0005395_other_phenotype0.62506792
86MP0002184_abnormal_innervation0.60452298
87MP0000230_abnormal_systemic_arterial0.59796423
88MP0004043_abnormal_pH_regulation0.59633989
89MP0009333_abnormal_splenocyte_physiolog0.57539503
90MP0005645_abnormal_hypothalamus_physiol0.57404550
91MP0004270_analgesia0.56715837
92MP0001697_abnormal_embryo_size0.56568639
93MP0008789_abnormal_olfactory_epithelium0.55455641
94MP0000647_abnormal_sebaceous_gland0.54521127
95MP0001944_abnormal_pancreas_morphology0.54121684
96MP0000733_abnormal_muscle_development0.54059110
97MP0002332_abnormal_exercise_endurance0.53417128
98MP0005551_abnormal_eye_electrophysiolog0.52850061
99MP0002229_neurodegeneration0.52524756
100MP0003959_abnormal_lean_body0.51995298

Predicted human phenotypes

RankGene SetZ-score
1Premature ovarian failure (HP:0008209)7.24727109
2Male infertility (HP:0003251)5.63117980
3Short tibia (HP:0005736)5.12955729
4Aplasia/Hypoplasia of the tibia (HP:0005772)4.83655798
5Median cleft lip (HP:0000161)4.33038897
6Microglossia (HP:0000171)4.23810882
7Facial cleft (HP:0002006)3.98421118
8Abnormal number of incisors (HP:0011064)3.57697474
9Oligodactyly (hands) (HP:0001180)3.53032005
10Abnormal pancreas size (HP:0012094)3.49526047
11Hyperphosphatemia (HP:0002905)3.22682371
12Tetany (HP:0001281)3.21105118
13Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.06002157
14Adrenal hypoplasia (HP:0000835)3.01136622
15Microretrognathia (HP:0000308)3.00384276
16Congenital malformation of the right heart (HP:0011723)2.93456464
17Double outlet right ventricle (HP:0001719)2.93456464
18Atonic seizures (HP:0010819)2.84007054
19Abnormality of the nasal septum (HP:0000419)2.81997879
20Anhidrosis (HP:0000970)2.71778803
21Glossoptosis (HP:0000162)2.71531802
22Chromsome breakage (HP:0040012)2.69115067
23Abnormal umbilical cord blood vessels (HP:0011403)2.65876026
24Single umbilical artery (HP:0001195)2.65876026
25Abnormality of the fetal cardiovascular system (HP:0010948)2.65876026
26Congenital sensorineural hearing impairment (HP:0008527)2.65316810
27Impulsivity (HP:0100710)2.64180124
28Tetraparesis (HP:0002273)2.62127243
29Metaphyseal dysplasia (HP:0100255)2.57117575
30Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.52368488
31Degeneration of the lateral corticospinal tracts (HP:0002314)2.52368488
32Birth length less than 3rd percentile (HP:0003561)2.52075546
33Oligodactyly (HP:0012165)2.51320743
34Abnormal auditory evoked potentials (HP:0006958)2.50343168
35Short chin (HP:0000331)2.48400594
36Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.48312645
37Rhinitis (HP:0012384)2.48172816
38Hypercortisolism (HP:0001578)2.48104464
39Reticulocytopenia (HP:0001896)2.46384016
40Abnormality of abdominal situs (HP:0011620)2.43420493
41Abdominal situs inversus (HP:0003363)2.43420493
42Ectopic kidney (HP:0000086)2.41730564
43Meckel diverticulum (HP:0002245)2.39257240
44Abnormality of the ileum (HP:0001549)2.35795723
45Absent rod-and cone-mediated responses on ERG (HP:0007688)2.33883540
46Patent foramen ovale (HP:0001655)2.33117998
47Abnormality of chromosome stability (HP:0003220)2.32984710
48Multiple enchondromatosis (HP:0005701)2.31089185
49Abnormality of the preputium (HP:0100587)2.30820093
50Abnormality of calcium-phosphate metabolism (HP:0100530)2.30769459
51Infertility (HP:0000789)2.29584998
52Sensory axonal neuropathy (HP:0003390)2.27639462
53Absent thumb (HP:0009777)2.26968832
54Renal Fanconi syndrome (HP:0001994)2.24679827
55Hypoplasia of the radius (HP:0002984)2.24202852
56Submucous cleft hard palate (HP:0000176)2.23531115
57Chromosomal breakage induced by crosslinking agents (HP:0003221)2.21294642
58Aplasia/Hypoplasia of the tongue (HP:0010295)2.20259721
59Cleft eyelid (HP:0000625)2.19145188
60Abnormality of lateral ventricle (HP:0030047)2.18001084
61Abnormality of the corticospinal tract (HP:0002492)2.16192845
62Osteomalacia (HP:0002749)2.15013583
63Abnormal ciliary motility (HP:0012262)2.14447993
64Supernumerary spleens (HP:0009799)2.13210571
65Maternal diabetes (HP:0009800)2.11302664
66Preauricular pit (HP:0004467)2.09545140
67Periauricular skin pits (HP:0100277)2.09545140
68Abnormality of alanine metabolism (HP:0010916)2.07884372
69Hyperalaninemia (HP:0003348)2.07884372
70Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.07884372
71Short thumb (HP:0009778)2.06255590
72Aplasia/Hypoplasia of the uvula (HP:0010293)2.06079970
73Constricted visual fields (HP:0001133)2.05936102
74Prostate neoplasm (HP:0100787)2.05120507
75Absent/shortened dynein arms (HP:0200106)2.03644723
76Dynein arm defect of respiratory motile cilia (HP:0012255)2.03644723
77Amelogenesis imperfecta (HP:0000705)2.03502668
78Myokymia (HP:0002411)2.02135756
79Anterior segment dysgenesis (HP:0007700)1.99719419
80Bony spicule pigmentary retinopathy (HP:0007737)1.98418187
81Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.98133277
82Increased hepatocellular lipid droplets (HP:0006565)1.96136852
83Increased CSF lactate (HP:0002490)1.96116447
84Abnormality of cells of the erythroid lineage (HP:0012130)1.94521144
85Abnormal respiratory motile cilium physiology (HP:0012261)1.94193324
86Aplasia/hypoplasia of the uterus (HP:0008684)1.94034471
87Abnormality of the incisor (HP:0000676)1.91916050
88Hypoplasia of the fovea (HP:0007750)1.90997038
89Aplasia/Hypoplasia of the fovea (HP:0008060)1.90997038
90Type I diabetes mellitus (HP:0100651)1.88464992
91Concave nail (HP:0001598)1.86460834
92Pancreatic fibrosis (HP:0100732)1.85735586
93Microvesicular hepatic steatosis (HP:0001414)1.85339352
94Hypophosphatemic rickets (HP:0004912)1.83737153
95Exertional dyspnea (HP:0002875)1.82449098
96Carpal bone hypoplasia (HP:0001498)1.82414415
97Pili torti (HP:0003777)1.82323931
98Aplasia/Hypoplasia involving the musculature (HP:0001460)1.76018306
99Abnormality of the labia minora (HP:0012880)1.71747485
100Glycosuria (HP:0003076)1.70716102

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK166.74981351
2TESK23.34759957
3SRPK13.25696796
4CDK193.24657386
5TAOK33.19270938
6LATS23.08314825
7BUB12.98431066
8TNIK2.95673939
9AURKA2.84317505
10PLK42.82287865
11CDK122.75570472
12VRK12.02099800
13ZAK1.89796471
14TLK11.83542382
15TRIM281.83111519
16STK391.74807278
17ACVR1B1.71733499
18PLK11.71211477
19CHEK21.68833261
20PBK1.64637528
21AURKB1.55408124
22BMPR1B1.54222706
23CDC71.40166944
24TTK1.40063432
25NUAK11.39415727
26PKN11.39062899
27VRK21.29510364
28EPHA41.26625275
29BRSK21.24175232
30BRSK11.21891244
31WNK11.15996986
32MELK1.12349030
33PIM21.09536057
34PLK31.06914323
35CDK71.03976466
36TEC1.02722259
37NLK0.96210844
38ICK0.89690932
39CHEK10.88299254
40OXSR10.87050649
41NEK60.84881404
42MAP3K30.81997274
43MARK30.79867539
44PLK20.74663267
45MAP2K30.73903546
46STK100.69651331
47BMX0.69582563
48LATS10.68998609
49EIF2AK30.68159563
50PAK10.66592876
51PDK20.65321641
52STK40.64996896
53STK30.64182448
54STK38L0.63509593
55CSNK2A10.63001515
56CSNK1E0.62324108
57RAF10.60763179
58PIM10.60108634
59PINK10.58965053
60GRK50.57253723
61NEK20.54647630
62PRKD10.53818803
63ARAF0.53088681
64CSNK2A20.50881632
65WNK40.50326617
66CDK20.50133909
67ATR0.49873641
68MAPKAPK20.49637533
69CAMK40.49326186
70AKT20.47644909
71GRK70.47561552
72PIK3CA0.45312680
73CDK90.45096870
74ILK0.44553757
75MAP3K50.43598963
76SGK20.42340026
77PRKACB0.42169554
78ATM0.41218444
79CDK10.41063081
80MARK20.40555705
81GSK3A0.40495917
82PIK3CG0.38999474
83OBSCN0.38860535
84PRKG10.37605070
85MAPK130.36271934
86GRK10.36198384
87NME10.35505238
88PRKACA0.35387952
89BRAF0.35304486
90PRKCI0.35273877
91STK240.34480631
92LIMK10.33919746
93LRRK20.33511283
94JAK30.30715739
95RPS6KA10.30489625
96MAPK110.28197780
97DYRK30.26706254
98ERBB40.26079012
99MTOR0.25687093
100KDR0.25432226

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005335.58840664
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.64578564
3Ribosome_Homo sapiens_hsa030104.62578678
4Basal transcription factors_Homo sapiens_hsa030223.53296544
5RNA polymerase_Homo sapiens_hsa030203.19611450
6Regulation of autophagy_Homo sapiens_hsa041402.97092955
7mRNA surveillance pathway_Homo sapiens_hsa030152.64104366
8RNA transport_Homo sapiens_hsa030132.53214726
9Mismatch repair_Homo sapiens_hsa034302.52249221
10Homologous recombination_Homo sapiens_hsa034402.47282539
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.37210895
12Fatty acid biosynthesis_Homo sapiens_hsa000612.27211809
13Fanconi anemia pathway_Homo sapiens_hsa034602.02735635
14Oocyte meiosis_Homo sapiens_hsa041142.02364640
15Folate biosynthesis_Homo sapiens_hsa007902.00689696
16Spliceosome_Homo sapiens_hsa030401.97919456
17Dorso-ventral axis formation_Homo sapiens_hsa043201.95492060
18Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.86879048
19RNA degradation_Homo sapiens_hsa030181.71551823
20Cell cycle_Homo sapiens_hsa041101.71457558
21Sulfur metabolism_Homo sapiens_hsa009201.56228346
22Pyrimidine metabolism_Homo sapiens_hsa002401.52845648
23DNA replication_Homo sapiens_hsa030301.47640547
24Bile secretion_Homo sapiens_hsa049761.42714028
25Olfactory transduction_Homo sapiens_hsa047401.36905589
26p53 signaling pathway_Homo sapiens_hsa041151.32593850
27Non-homologous end-joining_Homo sapiens_hsa034501.26755085
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.20530384
29Taste transduction_Homo sapiens_hsa047421.14453983
30Huntingtons disease_Homo sapiens_hsa050161.07608592
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.05177231
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03855929
33Insulin secretion_Homo sapiens_hsa049110.99945807
34Ovarian steroidogenesis_Homo sapiens_hsa049130.99834590
35Purine metabolism_Homo sapiens_hsa002300.98924686
36Hedgehog signaling pathway_Homo sapiens_hsa043400.96267949
37Systemic lupus erythematosus_Homo sapiens_hsa053220.90949674
38Retinol metabolism_Homo sapiens_hsa008300.79902583
39Linoleic acid metabolism_Homo sapiens_hsa005910.76729099
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73401717
41Alcoholism_Homo sapiens_hsa050340.73209891
42SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69716259
43Phototransduction_Homo sapiens_hsa047440.67986214
44Steroid biosynthesis_Homo sapiens_hsa001000.65750681
45Wnt signaling pathway_Homo sapiens_hsa043100.64631652
46Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64227328
47Cardiac muscle contraction_Homo sapiens_hsa042600.62920640
48Herpes simplex infection_Homo sapiens_hsa051680.61193511
49Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59658269
50Tight junction_Homo sapiens_hsa045300.59537221
51Viral carcinogenesis_Homo sapiens_hsa052030.58249108
52Base excision repair_Homo sapiens_hsa034100.58216891
53Drug metabolism - other enzymes_Homo sapiens_hsa009830.57781367
54Serotonergic synapse_Homo sapiens_hsa047260.56502135
55Chemical carcinogenesis_Homo sapiens_hsa052040.56200526
56Protein export_Homo sapiens_hsa030600.55125302
57Tryptophan metabolism_Homo sapiens_hsa003800.55062870
58Parkinsons disease_Homo sapiens_hsa050120.50531504
59Nucleotide excision repair_Homo sapiens_hsa034200.48528249
60Vitamin B6 metabolism_Homo sapiens_hsa007500.48418651
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46433807
62Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46229197
63Nicotine addiction_Homo sapiens_hsa050330.43868607
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43811709
65GABAergic synapse_Homo sapiens_hsa047270.42361760
66Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41681174
67Circadian rhythm_Homo sapiens_hsa047100.41110619
68Glutathione metabolism_Homo sapiens_hsa004800.40464113
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38289900
70Epstein-Barr virus infection_Homo sapiens_hsa051690.37819845
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.37722713
72Hippo signaling pathway_Homo sapiens_hsa043900.36422122
73Aldosterone synthesis and secretion_Homo sapiens_hsa049250.36256352
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.34742929
75Fatty acid elongation_Homo sapiens_hsa000620.30353089
76Inositol phosphate metabolism_Homo sapiens_hsa005620.29983732
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29780604
78Arachidonic acid metabolism_Homo sapiens_hsa005900.29048903
79Calcium signaling pathway_Homo sapiens_hsa040200.27740372
80Synaptic vesicle cycle_Homo sapiens_hsa047210.27133185
81Cholinergic synapse_Homo sapiens_hsa047250.25666366
82cAMP signaling pathway_Homo sapiens_hsa040240.25269385
83TGF-beta signaling pathway_Homo sapiens_hsa043500.20698571
84Morphine addiction_Homo sapiens_hsa050320.20698087
85Proteasome_Homo sapiens_hsa030500.19990729
86Cocaine addiction_Homo sapiens_hsa050300.19940597
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19686763
88MicroRNAs in cancer_Homo sapiens_hsa052060.18941363
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.18666081
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.17572554
91Basal cell carcinoma_Homo sapiens_hsa052170.16525413
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.16363595
93Metabolic pathways_Homo sapiens_hsa011000.15761674
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.15299997
95Amphetamine addiction_Homo sapiens_hsa050310.14966312
96Starch and sucrose metabolism_Homo sapiens_hsa005000.14296230
97Apoptosis_Homo sapiens_hsa042100.14096420
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.13502853
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.12872373
100Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.12577244

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