C1D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a DNA binding and apoptosis-inducing protein and is localized in the nucleus. It is also a Rac3-interacting protein which acts as a corepressor for the thyroid hormone receptor. This protein is thought to regulate TRAX/Translin complex formation. Alternate splicing results in multiple transcript variants that encode the same protein. Multiple pseudogenes of this gene are found on chromosome 10. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.55798002
2ATP synthesis coupled proton transport (GO:0015986)6.17400895
3energy coupled proton transport, down electrochemical gradient (GO:0015985)6.17400895
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.92255711
5protein neddylation (GO:0045116)5.27553385
6proteasome assembly (GO:0043248)5.22164610
7chaperone-mediated protein transport (GO:0072321)5.18248964
8respiratory electron transport chain (GO:0022904)5.11017413
9electron transport chain (GO:0022900)4.99237996
10mitochondrial respiratory chain complex I assembly (GO:0032981)4.84023319
11NADH dehydrogenase complex assembly (GO:0010257)4.84023319
12mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.84023319
13protein complex biogenesis (GO:0070271)4.80794754
14establishment of protein localization to mitochondrial membrane (GO:0090151)4.59882611
15mitochondrial respiratory chain complex assembly (GO:0033108)4.33185264
16dopamine transport (GO:0015872)4.23891939
17respiratory chain complex IV assembly (GO:0008535)4.18782511
18water-soluble vitamin biosynthetic process (GO:0042364)4.18189378
19GTP biosynthetic process (GO:0006183)4.07185310
20negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.06531262
21cullin deneddylation (GO:0010388)4.00282526
22regulation of cellular amino acid metabolic process (GO:0006521)3.96989339
23termination of RNA polymerase III transcription (GO:0006386)3.93952920
24transcription elongation from RNA polymerase III promoter (GO:0006385)3.93952920
257-methylguanosine mRNA capping (GO:0006370)3.87756156
267-methylguanosine RNA capping (GO:0009452)3.87238922
27RNA capping (GO:0036260)3.87238922
28protein deneddylation (GO:0000338)3.83024362
29ribosomal small subunit biogenesis (GO:0042274)3.81346034
30positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.78440561
31ribosomal small subunit assembly (GO:0000028)3.74308575
32L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.70304854
33negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.67884486
34negative regulation of ligase activity (GO:0051352)3.67884486
35cytochrome complex assembly (GO:0017004)3.63723216
36peptidyl-histidine modification (GO:0018202)3.62825535
37DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.62763825
38regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.61075857
39guanosine-containing compound biosynthetic process (GO:1901070)3.54984736
40intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.54217720
41signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.54217720
42platelet dense granule organization (GO:0060155)3.53293943
43signal peptide processing (GO:0006465)3.52918545
44antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.50587878
45signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.50461341
46signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.50461341
47signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.50461341
48protein targeting to mitochondrion (GO:0006626)3.50397747
49DNA deamination (GO:0045006)3.49039922
50regulation of mitochondrial translation (GO:0070129)3.48557259
51anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.41856223
52establishment of protein localization to mitochondrion (GO:0072655)3.40099119
53DNA double-strand break processing (GO:0000729)3.39865968
54oxidative phosphorylation (GO:0006119)3.39789256
55pseudouridine synthesis (GO:0001522)3.39279261
56signal transduction involved in DNA damage checkpoint (GO:0072422)3.33570571
57signal transduction involved in DNA integrity checkpoint (GO:0072401)3.33570571
58CENP-A containing nucleosome assembly (GO:0034080)3.31161956
59signal transduction involved in cell cycle checkpoint (GO:0072395)3.30611846
60rRNA methylation (GO:0031167)3.25724744
61UTP biosynthetic process (GO:0006228)3.23048711
62antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.22619216
63regulation of cellular amine metabolic process (GO:0033238)3.20791127
64establishment of integrated proviral latency (GO:0075713)3.20213240
65chromatin remodeling at centromere (GO:0031055)3.19994267
66cotranslational protein targeting to membrane (GO:0006613)3.17594718
67aerobic respiration (GO:0009060)3.17470720
68inner mitochondrial membrane organization (GO:0007007)3.17279020
69L-methionine salvage (GO:0071267)3.15149487
70L-methionine biosynthetic process (GO:0071265)3.15149487
71amino acid salvage (GO:0043102)3.15149487
72purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.14041850
73positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.13721490
74purine nucleoside triphosphate biosynthetic process (GO:0009145)3.12705958
75organelle disassembly (GO:1903008)3.09557205
76viral transcription (GO:0019083)3.09374826
77protein localization to mitochondrion (GO:0070585)3.09269764
78SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.09268232
79hydrogen transport (GO:0006818)3.08505772
80protein localization to endoplasmic reticulum (GO:0070972)3.07424083
81transcription elongation from RNA polymerase I promoter (GO:0006362)3.06530972
82protein targeting to ER (GO:0045047)3.05805061
83translational termination (GO:0006415)3.05357829
84positive regulation of ligase activity (GO:0051351)3.05259646
85hydrogen ion transmembrane transport (GO:1902600)3.02971066
86protein-cofactor linkage (GO:0018065)3.02505108
87pteridine-containing compound biosynthetic process (GO:0042559)3.01611861
88iron-sulfur cluster assembly (GO:0016226)3.01176622
89metallo-sulfur cluster assembly (GO:0031163)3.01176622
90translation (GO:0006412)3.00390860
91cellular component biogenesis (GO:0044085)2.96269056
92positive regulation of mitochondrial fission (GO:0090141)2.96154976
93histone mRNA metabolic process (GO:0008334)2.96056046
94tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.95723211
95RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.95723211
96establishment of viral latency (GO:0019043)2.91778288
97mannosylation (GO:0097502)2.91408900
98ribosomal large subunit biogenesis (GO:0042273)2.90669710
99nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.89521218
100mitochondrial transport (GO:0006839)2.88887550
101maturation of SSU-rRNA (GO:0030490)2.88246783
102regulation of cellular respiration (GO:0043457)2.87958693
103ATP biosynthetic process (GO:0006754)2.87429433
104establishment of protein localization to endoplasmic reticulum (GO:0072599)2.86248675
105CTP biosynthetic process (GO:0006241)2.86138560
106CTP metabolic process (GO:0046036)2.86138560
107transcription from RNA polymerase I promoter (GO:0006360)2.85855090
108intracellular protein transmembrane import (GO:0044743)2.84541643
109exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.84268238
110protein localization to cilium (GO:0061512)2.84027044
111termination of RNA polymerase I transcription (GO:0006363)2.83927781
112rRNA modification (GO:0000154)2.79453478
113preassembly of GPI anchor in ER membrane (GO:0016254)2.77619007
114proton transport (GO:0015992)2.77569031
115UTP metabolic process (GO:0046051)2.76309033
116deoxyribose phosphate biosynthetic process (GO:0046385)2.75131880
117tRNA processing (GO:0008033)2.74470899
118adenosine metabolic process (GO:0046085)2.71384416
119histone exchange (GO:0043486)2.71178738
120purine-containing compound salvage (GO:0043101)2.68865910
121anterograde synaptic vesicle transport (GO:0048490)2.68791431
122regulation of glucokinase activity (GO:0033131)2.67002366
123regulation of hexokinase activity (GO:1903299)2.67002366
124C-terminal protein lipidation (GO:0006501)2.65914441
125pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.65839661
126negative regulation of DNA-dependent DNA replication (GO:2000104)2.64395254
127DNA catabolic process, exonucleolytic (GO:0000738)2.62348954
128lactate metabolic process (GO:0006089)2.58868058
129regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.56569834

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.48911345
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.95369515
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.74637843
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.71041936
5* EST1_17652178_ChIP-ChIP_JURKAT_Human3.52216819
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.41556043
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.21397972
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.21182845
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.14560047
10TAF15_26573619_Chip-Seq_HEK293_Human2.85039106
11* ETS1_20019798_ChIP-Seq_JURKAT_Human2.71608197
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.71246140
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.61734697
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.61122081
15* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.54121168
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.40278789
17* ELK1_19687146_ChIP-ChIP_HELA_Human2.31393454
18PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.29137205
19* ELF1_17652178_ChIP-ChIP_JURKAT_Human2.21845450
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.21622594
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.18822405
22VDR_22108803_ChIP-Seq_LS180_Human2.15961420
23VDR_23849224_ChIP-Seq_CD4+_Human2.15825995
24SRF_21415370_ChIP-Seq_HL-1_Mouse2.15302688
25FUS_26573619_Chip-Seq_HEK293_Human2.08016640
26GBX2_23144817_ChIP-Seq_PC3_Human2.04283432
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.01566559
28POU3F2_20337985_ChIP-ChIP_501MEL_Human2.01478523
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.96981827
30FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.82392927
31MYC_18358816_ChIP-ChIP_MESCs_Mouse1.81038381
32EWS_26573619_Chip-Seq_HEK293_Human1.77799947
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.76929425
34DCP1A_22483619_ChIP-Seq_HELA_Human1.73143486
35EZH2_22144423_ChIP-Seq_EOC_Human1.69509450
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.69302105
37IGF1R_20145208_ChIP-Seq_DFB_Human1.66427298
38HOXB4_20404135_ChIP-ChIP_EML_Mouse1.63271450
39MYC_19030024_ChIP-ChIP_MESCs_Mouse1.62778691
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.60404600
41IRF1_19129219_ChIP-ChIP_H3396_Human1.60217532
42FOXP3_21729870_ChIP-Seq_TREG_Human1.60053675
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.58492684
44EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.55014197
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.54052267
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.53024511
47FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.51261047
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.49693651
49TTF2_22483619_ChIP-Seq_HELA_Human1.49347205
50ELK1_22589737_ChIP-Seq_MCF10A_Human1.43377988
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41171548
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.39700470
53* P300_19829295_ChIP-Seq_ESCs_Human1.39631856
54GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35940112
55MYC_18940864_ChIP-ChIP_HL60_Human1.33818373
56RBPJ_22232070_ChIP-Seq_NCS_Mouse1.33211208
57* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32910279
58* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.32267409
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32152369
60POU5F1_16153702_ChIP-ChIP_HESCs_Human1.30885242
61TP53_22573176_ChIP-Seq_HFKS_Human1.28887742
62CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.25771767
63YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25527228
64* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24642521
65CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.24446570
66RNF2_27304074_Chip-Seq_NSC_Mouse1.23703369
67* XRN2_22483619_ChIP-Seq_HELA_Human1.22788096
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.22435231
69EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.22071637
70MYC_19079543_ChIP-ChIP_MESCs_Mouse1.20760330
71CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.20613429
72GABP_19822575_ChIP-Seq_HepG2_Human1.19871622
73RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.19687860
74ER_23166858_ChIP-Seq_MCF-7_Human1.17529041
75FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.12247275
76NELFA_20434984_ChIP-Seq_ESCs_Mouse1.10761969
77ZNF274_21170338_ChIP-Seq_K562_Hela1.09542514
78CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.08137535
79SOX2_19829295_ChIP-Seq_ESCs_Human1.07933289
80NANOG_19829295_ChIP-Seq_ESCs_Human1.07933289
81SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.07812283
82MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06560479
83* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05563714
84FOXA1_25329375_ChIP-Seq_VCAP_Human1.03934908
85FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03934908
86TAL1_26923725_Chip-Seq_HPCs_Mouse1.01891785
87ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01486763
88IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.01179643
89AR_20517297_ChIP-Seq_VCAP_Human1.01080371
90NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.00936702
91* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00637925
92* JUN_21703547_ChIP-Seq_K562_Human1.00325809
93* CBP_20019798_ChIP-Seq_JUKART_Human1.00240205
94* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.00240205
95CRX_20693478_ChIP-Seq_RETINA_Mouse0.99782073
96SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99677466
97ERG_20887958_ChIP-Seq_HPC-7_Mouse0.98768764
98HTT_18923047_ChIP-ChIP_STHdh_Human0.98190839
99EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97632750
100KAP1_22055183_ChIP-Seq_ESCs_Mouse0.96889644
101* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96342028
102OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94980087
103E2F4_17652178_ChIP-ChIP_JURKAT_Human0.94433258
104POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94234764
105POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.94145234
106NANOG_18555785_Chip-Seq_ESCs_Mouse0.93501725
107NFE2_27457419_Chip-Seq_LIVER_Mouse0.92858011
108EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.91140774
109FOXA1_21572438_ChIP-Seq_LNCaP_Human0.90647122
110* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90388483
111CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90139097
112SALL4_22934838_ChIP-ChIP_CD34+_Human0.89991786
113REST_19997604_ChIP-ChIP_NEURONS_Mouse0.89797939
114P53_22387025_ChIP-Seq_ESCs_Mouse0.89603930
115SUZ12_18555785_Chip-Seq_ESCs_Mouse0.89501737
116STAT3_18555785_Chip-Seq_ESCs_Mouse0.89201218
117MYCN_18555785_ChIP-Seq_MESCs_Mouse0.88346776
118EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.87092070
119GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86623471
120NCOR_22424771_ChIP-Seq_293T_Human0.85576416
121EZH2_27294783_Chip-Seq_NPCs_Mouse0.84760980
122NMYC_18555785_Chip-Seq_ESCs_Mouse0.84735397
123MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.84119719
124EGR1_23403033_ChIP-Seq_LIVER_Mouse0.83540742

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.51472163
2MP0003880_abnormal_central_pattern4.05192073
3MP0001529_abnormal_vocalization3.67265164
4MP0006276_abnormal_autonomic_nervous3.27499873
5MP0001905_abnormal_dopamine_level3.21560467
6MP0003806_abnormal_nucleotide_metabolis3.17853575
7MP0009697_abnormal_copulation2.96884301
8MP0003195_calcinosis2.86823080
9MP0006292_abnormal_olfactory_placode2.82501749
10MP0001188_hyperpigmentation2.81556357
11MP0002837_dystrophic_cardiac_calcinosis2.73795534
12MP0001986_abnormal_taste_sensitivity2.69369305
13MP0006072_abnormal_retinal_apoptosis2.58348916
14MP0000372_irregular_coat_pigmentation2.23208851
15MP0002735_abnormal_chemical_nociception2.02154188
16MP0004142_abnormal_muscle_tone1.95392271
17MP0001968_abnormal_touch/_nociception1.94910148
18MP0002736_abnormal_nociception_after1.94777778
19MP0003787_abnormal_imprinting1.90362430
20MP0002876_abnormal_thyroid_physiology1.87316949
21MP0002102_abnormal_ear_morphology1.79886854
22MP0002734_abnormal_mechanical_nocicepti1.79814336
23MP0003718_maternal_effect1.79264555
24MP0009745_abnormal_behavioral_response1.77713316
25MP0005253_abnormal_eye_physiology1.77675517
26MP0005409_darkened_coat_color1.77382288
27MP0008260_abnormal_autophagy1.77298684
28MP0003136_yellow_coat_color1.76558095
29MP0002132_abnormal_respiratory_system1.72790924
30MP0003693_abnormal_embryo_hatching1.72741388
31MP0002163_abnormal_gland_morphology1.69560852
32MP0005332_abnormal_amino_acid1.64638064
33MP0006036_abnormal_mitochondrial_physio1.63894847
34MP0003122_maternal_imprinting1.63892874
35MP0006035_abnormal_mitochondrial_morpho1.63269531
36MP0002272_abnormal_nervous_system1.62772100
37MP0005171_absent_coat_pigmentation1.59129223
38MP0001440_abnormal_grooming_behavior1.52974008
39MP0008995_early_reproductive_senescence1.49925515
40MP0002938_white_spotting1.46598338
41MP0005551_abnormal_eye_electrophysiolog1.43695521
42MP0003724_increased_susceptibility_to1.43105129
43MP0002638_abnormal_pupillary_reflex1.42962685
44MP0002572_abnormal_emotion/affect_behav1.42834513
45MP0008007_abnormal_cellular_replicative1.42784430
46MP0001970_abnormal_pain_threshold1.41017880
47MP0002064_seizures1.39027181
48MP0003011_delayed_dark_adaptation1.38437285
49MP0005423_abnormal_somatic_nervous1.38109816
50MP0010386_abnormal_urinary_bladder1.32757718
51MP0005645_abnormal_hypothalamus_physiol1.32513838
52MP0002138_abnormal_hepatobiliary_system1.32217481
53MP0002693_abnormal_pancreas_physiology1.32028836
54MP0002090_abnormal_vision1.31966301
55MP0005084_abnormal_gallbladder_morpholo1.30393512
56MP0003635_abnormal_synaptic_transmissio1.29425229
57MP0002139_abnormal_hepatobiliary_system1.29154735
58MP0009046_muscle_twitch1.28840346
59MP0005408_hypopigmentation1.27060947
60MP0008932_abnormal_embryonic_tissue1.25086637
61MP0001542_abnormal_bone_strength1.24200574
62MP0002928_abnormal_bile_duct1.23973767
63MP0001486_abnormal_startle_reflex1.23157171
64MP0004957_abnormal_blastocyst_morpholog1.23102190
65MP0002184_abnormal_innervation1.22960385
66MP0002751_abnormal_autonomic_nervous1.22720364
67MP0003315_abnormal_perineum_morphology1.22380389
68MP0005636_abnormal_mineral_homeostasis1.21940509
69MP0003786_premature_aging1.21730587
70MP0001944_abnormal_pancreas_morphology1.21236943
71MP0005367_renal/urinary_system_phenotyp1.19975473
72MP0000516_abnormal_urinary_system1.19975473
73MP0002067_abnormal_sensory_capabilities1.19605566
74MP0002733_abnormal_thermal_nociception1.19002135
75MP0002063_abnormal_learning/memory/cond1.18334540
76MP0002254_reproductive_system_inflammat1.18178207
77MP0005379_endocrine/exocrine_gland_phen1.17326234
78MP0001984_abnormal_olfaction1.16851344
79MP0001501_abnormal_sleep_pattern1.16791568
80MP0003186_abnormal_redox_activity1.16483715
81MP0008789_abnormal_olfactory_epithelium1.15950606
82MP0004270_analgesia1.15711502
83MP0004147_increased_porphyrin_level1.13939639
84MP0005386_behavior/neurological_phenoty1.13099493
85MP0004924_abnormal_behavior1.13099493
86MP0001764_abnormal_homeostasis1.11889994
87MP0008875_abnormal_xenobiotic_pharmacok1.07536803
88MP0004215_abnormal_myocardial_fiber1.03762960
89MP0005075_abnormal_melanosome_morpholog1.03451874
90MP0005410_abnormal_fertilization1.02591941
91MP0002277_abnormal_respiratory_mucosa1.02462521
92MP0000631_abnormal_neuroendocrine_gland1.02005358
93MP0000778_abnormal_nervous_system1.01731326
94MP0000015_abnormal_ear_pigmentation1.00779399
95MP0005646_abnormal_pituitary_gland0.99887652
96MP0008877_abnormal_DNA_methylation0.99150789
97MP0003646_muscle_fatigue0.99083673
98MP0002009_preneoplasia0.98677339
99MP0005220_abnormal_exocrine_pancreas0.98311739
100MP0002822_catalepsy0.93288497
101MP0003123_paternal_imprinting0.92955392
102MP0004133_heterotaxia0.92510707
103MP0000358_abnormal_cell_content/0.90417407
104MP0000026_abnormal_inner_ear0.89391191
105MP0001963_abnormal_hearing_physiology0.89106331
106MP0006054_spinal_hemorrhage0.87858053
107MP0001929_abnormal_gametogenesis0.87052774
108MP0002160_abnormal_reproductive_system0.86942840
109MP0003252_abnormal_bile_duct0.86390745
110MP0004019_abnormal_vitamin_homeostasis0.86350289
111MP0002148_abnormal_hypersensitivity_rea0.83739126
112MP0002210_abnormal_sex_determination0.83336081
113MP0000538_abnormal_urinary_bladder0.82657787
114MP0008058_abnormal_DNA_repair0.82001824
115MP0002909_abnormal_adrenal_gland0.81839497
116MP0004742_abnormal_vestibular_system0.81541888
117MP0009785_altered_susceptibility_to0.80946519
118MP0003567_abnormal_fetal_cardiomyocyte0.80796645
119MP0002095_abnormal_skin_pigmentation0.80549137
120MP0005389_reproductive_system_phenotype0.80075408
121MP0000653_abnormal_sex_gland0.79995229
122MP0005394_taste/olfaction_phenotype0.79986120
123MP0005499_abnormal_olfactory_system0.79986120
124MP0001664_abnormal_digestion0.79851592
125MP0005266_abnormal_metabolism0.76002963
126MP0003121_genomic_imprinting0.75380733
127MP0001145_abnormal_male_reproductive0.75015599
128MP0001485_abnormal_pinna_reflex0.74827862
129MP0005671_abnormal_response_to0.74286195
130MP0010094_abnormal_chromosome_stability0.74217467
131MP0002557_abnormal_social/conspecific_i0.74212828
132MP0001324_abnormal_eye_pigmentation0.73390145
133MP0005535_abnormal_body_temperature0.73302791
134MP0004043_abnormal_pH_regulation0.73013020
135MP0004381_abnormal_hair_follicle0.72405149
136MP0000681_abnormal_thyroid_gland0.71480817
137MP0008872_abnormal_physiological_respon0.71463327
138MP0000639_abnormal_adrenal_gland0.70651092
139MP0001756_abnormal_urination0.70634298
140MP0004145_abnormal_muscle_electrophysio0.70562864
141MP0001919_abnormal_reproductive_system0.69601711
142MP0002653_abnormal_ependyma_morphology0.68684872
143MP0002078_abnormal_glucose_homeostasis0.68338539
144MP0002752_abnormal_somatic_nervous0.68062947
145MP0001727_abnormal_embryo_implantation0.67870918
146MP0008057_abnormal_DNA_replication0.67783577
147MP0003077_abnormal_cell_cycle0.67662001
148MP0002066_abnormal_motor_capabilities/c0.67611115
149MP0005174_abnormal_tail_pigmentation0.67532731

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.23921637
2Abnormal mitochondria in muscle tissue (HP:0008316)5.62729194
3Mitochondrial inheritance (HP:0001427)5.42711798
4Progressive macrocephaly (HP:0004481)5.30897216
5Acute encephalopathy (HP:0006846)5.11272423
6Increased CSF lactate (HP:0002490)4.81438528
7Hepatocellular necrosis (HP:0001404)4.73260605
8Increased hepatocellular lipid droplets (HP:0006565)4.06211463
9Hepatic necrosis (HP:0002605)3.99048665
10Renal Fanconi syndrome (HP:0001994)3.79272275
11Increased serum pyruvate (HP:0003542)3.72576320
12Abnormality of glycolysis (HP:0004366)3.72576320
13Hypothermia (HP:0002045)3.60675150
143-Methylglutaconic aciduria (HP:0003535)3.58322793
15Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.53587767
16Methylmalonic acidemia (HP:0002912)3.52515245
17Lipid accumulation in hepatocytes (HP:0006561)3.51913476
18Cerebral edema (HP:0002181)3.49283729
19Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.35632078
20Optic disc pallor (HP:0000543)3.30578786
21Increased serum lactate (HP:0002151)3.14468122
22Abnormality of cells of the erythroid lineage (HP:0012130)3.13131106
23Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.10771022
24Decreased activity of mitochondrial respiratory chain (HP:0008972)3.10771022
25Lactic acidosis (HP:0003128)3.05536687
26Respiratory difficulties (HP:0002880)3.02234025
27Exercise intolerance (HP:0003546)3.01300257
28Parakeratosis (HP:0001036)2.99655921
29Abnormal number of erythroid precursors (HP:0012131)2.96153643
30Respiratory failure (HP:0002878)2.92337067
31Leukodystrophy (HP:0002415)2.92317089
32Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.91655132
33Abnormal hair whorl (HP:0010721)2.87485174
34Methylmalonic aciduria (HP:0012120)2.81151960
35Exertional dyspnea (HP:0002875)2.71336508
36Increased intramyocellular lipid droplets (HP:0012240)2.71320504
37Hypoglycemic coma (HP:0001325)2.67809074
38Birth length less than 3rd percentile (HP:0003561)2.63394944
39Neuroendocrine neoplasm (HP:0100634)2.48947113
40Medial flaring of the eyebrow (HP:0010747)2.47210272
41Congenital, generalized hypertrichosis (HP:0004540)2.44983075
42Limb dystonia (HP:0002451)2.43325307
43Abnormality of vitamin B metabolism (HP:0004340)2.37977118
44Abnormality of aromatic amino acid family metabolism (HP:0004338)2.33069812
45Poor suck (HP:0002033)2.31244634
46Abnormality of renal resorption (HP:0011038)2.27873248
47X-linked dominant inheritance (HP:0001423)2.26155515
48Gait imbalance (HP:0002141)2.23193479
49Abnormality of methionine metabolism (HP:0010901)2.19993543
50Aplastic anemia (HP:0001915)2.19218317
51Abnormality of aspartate family amino acid metabolism (HP:0010899)2.19116879
52Pancreatic fibrosis (HP:0100732)2.18168492
53Type I transferrin isoform profile (HP:0003642)2.17609048
54Cerebral hypomyelination (HP:0006808)2.17285344
55Retinal dysplasia (HP:0007973)2.15515000
56Hyperinsulinemic hypoglycemia (HP:0000825)2.15272505
57Renal cortical cysts (HP:0000803)2.15182017
58Generalized aminoaciduria (HP:0002909)2.13264343
59CNS demyelination (HP:0007305)2.11427916
60Congenital primary aphakia (HP:0007707)2.10974309
61Abnormality of midbrain morphology (HP:0002418)2.09938034
62Molar tooth sign on MRI (HP:0002419)2.09938034
63Microvesicular hepatic steatosis (HP:0001414)2.06645153
64Reticulocytopenia (HP:0001896)2.06291966
65Palpitations (HP:0001962)2.05873637
66Macrocytic anemia (HP:0001972)2.05748862
67Hypoglycemic seizures (HP:0002173)2.05430339
68Abnormality of the renal cortex (HP:0011035)2.05196186
69Nephrogenic diabetes insipidus (HP:0009806)2.05166812
70Increased muscle lipid content (HP:0009058)2.05002009
71Pheochromocytoma (HP:0002666)2.04413964
72Abnormality of the heme biosynthetic pathway (HP:0010472)2.04092652
73Neoplasm of the adrenal gland (HP:0100631)2.02586526
74Hyperphosphaturia (HP:0003109)2.02578094
75Amniotic constriction ring (HP:0009775)2.02301877
76Abnormality of placental membranes (HP:0011409)2.02301877
77Abnormal pupillary function (HP:0007686)2.01392420
78Ketoacidosis (HP:0001993)2.01151094
79Abnormality of the vitamin B12 metabolism (HP:0004341)2.00499330
80Abnormality of serum amino acid levels (HP:0003112)1.97441790
81Patchy hypopigmentation of hair (HP:0011365)1.96092219
82Congenital ichthyosiform erythroderma (HP:0007431)1.95947904
83Delusions (HP:0000746)1.95220925
84Lethargy (HP:0001254)1.93444899
85Degeneration of anterior horn cells (HP:0002398)1.91285757
86Abnormality of the anterior horn cell (HP:0006802)1.91285757
87Focal motor seizures (HP:0011153)1.91259119
88Reduced antithrombin III activity (HP:0001976)1.90693889
89Emotional lability (HP:0000712)1.88657670
90Abnormality of dicarboxylic acid metabolism (HP:0010995)1.87955257
91Dicarboxylic aciduria (HP:0003215)1.87955257
92Aplasia/hypoplasia of the uterus (HP:0008684)1.87090951
93Aplasia/Hypoplasia of the tibia (HP:0005772)1.86548092
94True hermaphroditism (HP:0010459)1.85411186
95Conjunctival hamartoma (HP:0100780)1.84148353
96Type 2 muscle fiber atrophy (HP:0003554)1.83419796
97Hypokinesia (HP:0002375)1.83218416
98Breast hypoplasia (HP:0003187)1.82772080
99Pancreatic cysts (HP:0001737)1.81828426
100Pallor (HP:0000980)1.81290043
101Irregular epiphyses (HP:0010582)1.80843062
102Metaphyseal dysplasia (HP:0100255)1.80723972
103Congenital stationary night blindness (HP:0007642)1.80562351
104Abnormal rod and cone electroretinograms (HP:0008323)1.80119763
105Abnormality of urine glucose concentration (HP:0011016)1.79954278
106Glycosuria (HP:0003076)1.79954278
107Constricted visual fields (HP:0001133)1.79413973
108Abnormality of endocrine pancreas physiology (HP:0012093)1.79367577
109Abnormality of the pancreatic islet cells (HP:0006476)1.79367577
110Hyperglycinemia (HP:0002154)1.78144957
111Abnormality of the labia minora (HP:0012880)1.77830742
112Abnormality of secondary sexual hair (HP:0009888)1.77644950
113Abnormality of the axillary hair (HP:0100134)1.77644950
114Pancreatic islet-cell hyperplasia (HP:0004510)1.77470829
115Esotropia (HP:0000565)1.77065594
116Intestinal atresia (HP:0011100)1.77000947
117Nephronophthisis (HP:0000090)1.76706986
118Hypoplastic left heart (HP:0004383)1.73721844
119Unsteady gait (HP:0002317)1.72783472
120Hypoplasia of the uterus (HP:0000013)1.71870844
121Short tibia (HP:0005736)1.71274895
122Genital tract atresia (HP:0001827)1.69964645
123Vaginal atresia (HP:0000148)1.67554682
124Abnormal protein glycosylation (HP:0012346)1.66577870
125Abnormal glycosylation (HP:0012345)1.66577870
126Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.66577870
127Abnormal protein N-linked glycosylation (HP:0012347)1.66577870
128Abnormality of alanine metabolism (HP:0010916)1.66408536
129Hyperalaninemia (HP:0003348)1.66408536
130Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.66408536
131Abnormality of vitamin metabolism (HP:0100508)1.65973209
132Megaloblastic anemia (HP:0001889)1.65859718
133Lissencephaly (HP:0001339)1.65694184
134Metabolic acidosis (HP:0001942)1.65082422
135Type II lissencephaly (HP:0007260)1.65024355
136Ketosis (HP:0001946)1.65002914
137Renal tubular dysfunction (HP:0000124)1.63986931
138Sclerocornea (HP:0000647)1.62877359
139Oral leukoplakia (HP:0002745)1.61381050
140Abnormal spermatogenesis (HP:0008669)1.59601268
141Poor coordination (HP:0002370)1.58637352
142Adrenal hypoplasia (HP:0000835)1.58430259

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK163.71582927
2FRK3.66098512
3MAP3K123.39164078
4EIF2AK13.38726351
5EIF2AK32.99028300
6CASK2.87171514
7VRK22.81110940
8MAP4K22.67420924
9NUAK12.51449643
10MKNK12.46612393
11BUB12.29105671
12MUSK2.26149154
13NME12.24249696
14MKNK22.23338363
15TNIK2.07700638
16MAP2K72.01993723
17SRPK12.01576506
18NME21.94774694
19GRK71.92515537
20VRK11.85910925
21TRIM281.84916535
22MST41.84845197
23WEE11.73630111
24ADRBK21.59926027
25ERBB31.55180592
26BMPR1B1.55112251
27ARAF1.54842435
28CDK81.54360544
29PBK1.53017213
30BCR1.42461869
31PLK41.42350014
32PLK21.40374334
33MAPK131.35670678
34MYLK1.33172391
35MAPKAPK51.32891698
36BMPR21.28978763
37TAF11.27722419
38ACVR1B1.27290326
39DYRK21.24532514
40EIF2AK21.23607397
41CSNK1G31.22284844
42PASK1.19558097
43NEK11.11487772
44CDC71.11271524
45LIMK11.08948518
46BRSK21.07545354
47GRK51.06726539
48TXK1.06539856
49PINK11.01994363
50YES11.01188902
51STK31.00762001
52MARK10.98324856
53CCNB10.97708442
54PIM20.96859321
55STK38L0.92966556
56MAP2K60.85416856
57CSNK1G10.84555914
58CSNK1G20.81886822
59AKT30.81706429
60PLK30.81287298
61OXSR10.81166543
62PNCK0.80892342
63BRAF0.80793829
64PHKG20.79352209
65PHKG10.79352209
66MAP3K40.78639141
67TSSK60.74583983
68CDK190.73402305
69TAOK30.70665392
70ZAK0.69298387
71WNK40.69243763
72INSRR0.69051031
73MINK10.66615272
74PDK20.64916042
75DAPK10.64544421
76CAMK2B0.64496330
77PAK30.64030302
78OBSCN0.62916870
79ADRBK10.62673760
80IRAK30.62645528
81NTRK30.62609895
82IRAK40.61843404
83IKBKB0.61543448
84STK240.60636286
85ABL20.59942098
86RIPK40.59540574
87CSNK2A10.59464636
88TIE10.58292500
89NEK60.58095244
90CAMK2A0.56750376
91BCKDK0.55853407
92DYRK30.53599657
93TTK0.53526655
94MAP2K40.53327533
95TNK20.52972598
96FGFR20.52948948
97MAPKAPK30.52087296
98NLK0.51257707
99DAPK20.50127995
100CDK30.50114614
101WNK30.49419353
102TLK10.49225336
103RPS6KA40.48718192
104CAMKK20.48559032
105STK40.48556747
106DYRK1A0.46936304
107PRKCG0.46515328
108AURKA0.46140587
109RPS6KA50.44888733
110UHMK10.44662984
111TEC0.44618066
112PRKCE0.41598020
113CSNK2A20.41114389
114MAPK40.41107214
115CSNK1A1L0.41055246
116STK390.39566963
117CDK140.39324576
118CAMK2G0.37959686
119CDK180.37549820
120PRKCI0.37448852
121AURKB0.33765871
122GRK10.32954357
123LYN0.32933076
124PLK10.32909846
125NEK90.32540034
126CSNK1A10.31998807
127FES0.31436507
128MAP3K60.31175555
129CDK150.30212447
130PRKACA0.30187487
131CLK10.29932029
132ATR0.29819120
133CAMK2D0.29529709
134SYK0.29298730
135BRSK10.29215456
136TGFBR10.28452404
137CDK11A0.28034283

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.01763145
2Proteasome_Homo sapiens_hsa030504.55727764
3Parkinsons disease_Homo sapiens_hsa050124.40140677
4Ribosome_Homo sapiens_hsa030103.95641422
5RNA polymerase_Homo sapiens_hsa030203.41054298
6Alzheimers disease_Homo sapiens_hsa050103.17774781
7Huntingtons disease_Homo sapiens_hsa050163.14889011
8Protein export_Homo sapiens_hsa030603.10553174
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.48114771
10Maturity onset diabetes of the young_Homo sapiens_hsa049502.31888175
11Pyrimidine metabolism_Homo sapiens_hsa002402.10759815
12Homologous recombination_Homo sapiens_hsa034401.88342000
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.85792350
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.77667233
15DNA replication_Homo sapiens_hsa030301.75345129
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.74570953
17Spliceosome_Homo sapiens_hsa030401.74502807
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.73214876
19Collecting duct acid secretion_Homo sapiens_hsa049661.72217151
20Basal transcription factors_Homo sapiens_hsa030221.62885555
21Mismatch repair_Homo sapiens_hsa034301.62241253
22SNARE interactions in vesicular transport_Homo sapiens_hsa041301.60409425
23Nicotine addiction_Homo sapiens_hsa050331.46419250
24Nucleotide excision repair_Homo sapiens_hsa034201.44736213
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.42351226
26One carbon pool by folate_Homo sapiens_hsa006701.40030468
27Fatty acid elongation_Homo sapiens_hsa000621.34325648
28Cardiac muscle contraction_Homo sapiens_hsa042601.34248589
29Purine metabolism_Homo sapiens_hsa002301.33403778
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.23122749
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.16008378
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.14275002
33RNA transport_Homo sapiens_hsa030131.06750632
34Vibrio cholerae infection_Homo sapiens_hsa051101.06144485
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06100049
36* RNA degradation_Homo sapiens_hsa030181.04535640
37Rheumatoid arthritis_Homo sapiens_hsa053230.99257794
38Steroid biosynthesis_Homo sapiens_hsa001000.94512527
39Serotonergic synapse_Homo sapiens_hsa047260.89549234
40Selenocompound metabolism_Homo sapiens_hsa004500.88031416
41Synaptic vesicle cycle_Homo sapiens_hsa047210.86990625
42Sulfur metabolism_Homo sapiens_hsa009200.85904446
43Regulation of autophagy_Homo sapiens_hsa041400.83731001
44Vitamin B6 metabolism_Homo sapiens_hsa007500.83506689
45Tryptophan metabolism_Homo sapiens_hsa003800.82982432
46Fanconi anemia pathway_Homo sapiens_hsa034600.82769057
47Metabolic pathways_Homo sapiens_hsa011000.82317850
48Phototransduction_Homo sapiens_hsa047440.80396383
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77282880
50Arachidonic acid metabolism_Homo sapiens_hsa005900.76305394
51Glutathione metabolism_Homo sapiens_hsa004800.74317395
52Non-homologous end-joining_Homo sapiens_hsa034500.73977834
53Primary bile acid biosynthesis_Homo sapiens_hsa001200.71751526
54Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69918689
55Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.67708561
56Phagosome_Homo sapiens_hsa041450.66378207
57Cell cycle_Homo sapiens_hsa041100.64721389
58Ether lipid metabolism_Homo sapiens_hsa005650.64371422
59Base excision repair_Homo sapiens_hsa034100.62893542
60Sulfur relay system_Homo sapiens_hsa041220.61084254
61Fatty acid degradation_Homo sapiens_hsa000710.60713162
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.58061912
63Folate biosynthesis_Homo sapiens_hsa007900.56492664
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55264015
65Fatty acid metabolism_Homo sapiens_hsa012120.54912435
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54692441
67Nitrogen metabolism_Homo sapiens_hsa009100.53725098
68Taste transduction_Homo sapiens_hsa047420.53439759
69Retinol metabolism_Homo sapiens_hsa008300.53246820
70Caffeine metabolism_Homo sapiens_hsa002320.52287221
71GABAergic synapse_Homo sapiens_hsa047270.51431019
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50655013
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50645751
74Tyrosine metabolism_Homo sapiens_hsa003500.48802950
75Peroxisome_Homo sapiens_hsa041460.48645886
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48110324
77Epstein-Barr virus infection_Homo sapiens_hsa051690.46550162
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46344525
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46142610
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.44436590
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44132009
82beta-Alanine metabolism_Homo sapiens_hsa004100.43930952
83Chemical carcinogenesis_Homo sapiens_hsa052040.43021188
84Sphingolipid metabolism_Homo sapiens_hsa006000.42950625
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.41852727
86Autoimmune thyroid disease_Homo sapiens_hsa053200.41796648
87Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40664793
88Allograft rejection_Homo sapiens_hsa053300.40332577
89Propanoate metabolism_Homo sapiens_hsa006400.40129079
90Asthma_Homo sapiens_hsa053100.38686186
91Butanoate metabolism_Homo sapiens_hsa006500.38326103
92Legionellosis_Homo sapiens_hsa051340.36265480
93Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.36131588
94Graft-versus-host disease_Homo sapiens_hsa053320.35918930
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35010113
96Linoleic acid metabolism_Homo sapiens_hsa005910.34648550
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34233645
98Oocyte meiosis_Homo sapiens_hsa041140.34225141
99Pyruvate metabolism_Homo sapiens_hsa006200.32793073
100Dopaminergic synapse_Homo sapiens_hsa047280.32718801
101alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32693885
102Cyanoamino acid metabolism_Homo sapiens_hsa004600.31924992
103Primary immunodeficiency_Homo sapiens_hsa053400.31845254
104Amphetamine addiction_Homo sapiens_hsa050310.31837137
105Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.31748219
106Long-term depression_Homo sapiens_hsa047300.30213675
107Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.29215789
108Circadian rhythm_Homo sapiens_hsa047100.28891987
109Glutamatergic synapse_Homo sapiens_hsa047240.28456824
110Carbon metabolism_Homo sapiens_hsa012000.27849361
111Mineral absorption_Homo sapiens_hsa049780.27236024
112Alcoholism_Homo sapiens_hsa050340.27056283
113Histidine metabolism_Homo sapiens_hsa003400.26936037
114Morphine addiction_Homo sapiens_hsa050320.26850811
115Intestinal immune network for IgA production_Homo sapiens_hsa046720.25070167
116Steroid hormone biosynthesis_Homo sapiens_hsa001400.24871663
117Type I diabetes mellitus_Homo sapiens_hsa049400.24553736
118Vitamin digestion and absorption_Homo sapiens_hsa049770.24332123
119Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.24153590
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.22836357
121African trypanosomiasis_Homo sapiens_hsa051430.22650482
122Phenylalanine metabolism_Homo sapiens_hsa003600.21317576
123Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20981222
124N-Glycan biosynthesis_Homo sapiens_hsa005100.20032322

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