C19ORF81

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)6.57279003
2viral transcription (GO:0019083)6.11708374
3translational termination (GO:0006415)5.74426173
4ribosomal small subunit assembly (GO:0000028)5.40496516
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.32954771
6ATP synthesis coupled proton transport (GO:0015986)5.32954771
7deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.07431165
8translational elongation (GO:0006414)5.05028122
9mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.78470160
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.75229917
11cotranslational protein targeting to membrane (GO:0006613)4.68505679
12protein targeting to ER (GO:0045047)4.61996115
13cellular protein complex disassembly (GO:0043624)4.54952925
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.48744580
15viral life cycle (GO:0019058)4.48030759
16establishment of protein localization to endoplasmic reticulum (GO:0072599)4.43497905
17protein localization to endoplasmic reticulum (GO:0070972)4.40824673
18nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.37799159
19establishment of protein localization to mitochondrial membrane (GO:0090151)4.36138127
20pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.21901389
21maturation of SSU-rRNA (GO:0030490)4.21169913
22protein complex disassembly (GO:0043241)4.17575098
23mitochondrial respiratory chain complex I assembly (GO:0032981)4.12633378
24NADH dehydrogenase complex assembly (GO:0010257)4.12633378
25mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.12633378
26protein complex biogenesis (GO:0070271)4.09996229
27macromolecular complex disassembly (GO:0032984)3.99800587
28respiratory electron transport chain (GO:0022904)3.99354636
29electron transport chain (GO:0022900)3.91915047
30translational initiation (GO:0006413)3.74632470
31mitochondrial respiratory chain complex assembly (GO:0033108)3.72659667
32pyrimidine nucleotide catabolic process (GO:0006244)3.65386262
33ATP biosynthetic process (GO:0006754)3.63579040
34purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.59415455
35chaperone-mediated protein transport (GO:0072321)3.53762106
36ncRNA 3-end processing (GO:0043628)3.53257437
37purine nucleoside triphosphate biosynthetic process (GO:0009145)3.49383619
38ribonucleoside triphosphate biosynthetic process (GO:0009201)3.46263840
39GTP biosynthetic process (GO:0006183)3.46230771
40protein targeting to mitochondrion (GO:0006626)3.45555307
41base-excision repair, AP site formation (GO:0006285)3.43557499
42pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.40810898
43deoxyribonucleotide catabolic process (GO:0009264)3.40660016
44establishment of protein localization to mitochondrion (GO:0072655)3.39116620
45iron-sulfur cluster assembly (GO:0016226)3.34615846
46metallo-sulfur cluster assembly (GO:0031163)3.34615846
47positive regulation of prostaglandin secretion (GO:0032308)3.30792102
48pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.28403518
49purine deoxyribonucleotide catabolic process (GO:0009155)3.25772603
50UTP biosynthetic process (GO:0006228)3.25302617
51pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.24625789
52translation (GO:0006412)3.24182217
53CTP metabolic process (GO:0046036)3.23565103
54CTP biosynthetic process (GO:0006241)3.23565103
55protein neddylation (GO:0045116)3.22875060
56substrate-independent telencephalic tangential migration (GO:0021826)3.21150651
57substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.21150651
58protein targeting to membrane (GO:0006612)3.19752061
59cellular component biogenesis (GO:0044085)3.17772161
60protein localization to mitochondrion (GO:0070585)3.14332395
61deoxyribose phosphate catabolic process (GO:0046386)3.13838684
62pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.09709529
63spinal cord association neuron differentiation (GO:0021527)3.08207387
64regulation of mitochondrial translation (GO:0070129)3.07291808
65transcription elongation from RNA polymerase III promoter (GO:0006385)3.04925384
66termination of RNA polymerase III transcription (GO:0006386)3.04925384
67nuclear-transcribed mRNA catabolic process (GO:0000956)3.03382125
68nucleoside triphosphate biosynthetic process (GO:0009142)3.02273343
69oxidative phosphorylation (GO:0006119)3.00082243
70nonmotile primary cilium assembly (GO:0035058)2.95800461
71UTP metabolic process (GO:0046051)2.94969238
72mRNA catabolic process (GO:0006402)2.89932924
73hydrogen ion transmembrane transport (GO:1902600)2.88656876
74pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.88179307
75ribonucleoprotein complex biogenesis (GO:0022613)2.86163411
76positive regulation of icosanoid secretion (GO:0032305)2.86037661
77guanosine-containing compound biosynthetic process (GO:1901070)2.85792670
78ribosomal large subunit biogenesis (GO:0042273)2.80632915
79RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.79857592
80tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.79857592
81positive regulation of fatty acid transport (GO:2000193)2.78384670
82behavioral response to nicotine (GO:0035095)2.77742374
83cell proliferation in forebrain (GO:0021846)2.74900229
84pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.72265989
85establishment of mitochondrion localization (GO:0051654)2.71895447
862-deoxyribonucleotide metabolic process (GO:0009394)2.71854259
87pyrimidine nucleotide biosynthetic process (GO:0006221)2.68830688
882-deoxyribonucleotide biosynthetic process (GO:0009265)2.66550856
89deoxyribose phosphate biosynthetic process (GO:0046385)2.66550856
90protein-cofactor linkage (GO:0018065)2.65237176
91RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.64439283
92left/right pattern formation (GO:0060972)2.63425755
93positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.62352939
94regulation of prostaglandin secretion (GO:0032306)2.61532832
95neurofilament cytoskeleton organization (GO:0060052)2.60193641
96positive regulation of potassium ion transmembrane transport (GO:1901381)2.59477026
97RNA catabolic process (GO:0006401)2.57477434
98pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.56975279
99purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.55618267
100purine nucleoside monophosphate biosynthetic process (GO:0009127)2.55618267

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.95785918
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.84174505
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.20400311
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.92296688
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.86537829
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.78359630
7ETS1_20019798_ChIP-Seq_JURKAT_Human2.70166574
8THAP11_20581084_ChIP-Seq_MESCs_Mouse2.44910770
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.39178434
10XRN2_22483619_ChIP-Seq_HELA_Human2.38184565
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.27195065
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.26968261
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.12353160
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.03876276
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.01810355
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.01670410
17CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.01144446
18YY1_21170310_ChIP-Seq_MESCs_Mouse2.00411867
19GABP_19822575_ChIP-Seq_HepG2_Human1.99860967
20PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.96397873
21CREB1_15753290_ChIP-ChIP_HEK293T_Human1.93169729
22SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.90625666
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.89442890
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.88436142
25TET1_21451524_ChIP-Seq_MESCs_Mouse1.78609874
26TTF2_22483619_ChIP-Seq_HELA_Human1.76247022
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.76070006
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.73104836
29CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.70992716
30MYC_19079543_ChIP-ChIP_MESCs_Mouse1.65953980
31CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.64459418
32SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.59613263
33EZH2_27304074_Chip-Seq_ESCs_Mouse1.58772094
34HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.56374227
35MYC_19030024_ChIP-ChIP_MESCs_Mouse1.55364289
36KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.55292979
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.55108856
38ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.54372311
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.53206345
40CTCF_18555785_ChIP-Seq_MESCs_Mouse1.51086878
41JARID2_20064375_ChIP-Seq_MESCs_Mouse1.50889039
42E2F1_18555785_ChIP-Seq_MESCs_Mouse1.45415955
43ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.45242614
44SUZ12_27294783_Chip-Seq_ESCs_Mouse1.43086278
45JARID2_20075857_ChIP-Seq_MESCs_Mouse1.41181012
46P68_20966046_ChIP-Seq_HELA_Human1.40888811
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.40393448
48FOXP1_21924763_ChIP-Seq_HESCs_Human1.40362226
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.38364645
50EED_16625203_ChIP-ChIP_MESCs_Mouse1.37773440
51DCP1A_22483619_ChIP-Seq_HELA_Human1.35872305
52IRF1_19129219_ChIP-ChIP_H3396_Human1.34657805
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.30094257
54SOX2_18555785_ChIP-Seq_MESCs_Mouse1.29697221
55CTCF_27219007_Chip-Seq_Bcells_Human1.28474417
56SRF_21415370_ChIP-Seq_HL-1_Mouse1.26914754
57TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26648017
58DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.23707843
59BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22706124
60ELF1_20517297_ChIP-Seq_JURKAT_Human1.22585807
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21693697
62MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.20791055
63ZNF263_19887448_ChIP-Seq_K562_Human1.20434399
64REST_18959480_ChIP-ChIP_MESCs_Mouse1.20164847
65KDM5A_27292631_Chip-Seq_BREAST_Human1.19677450
66REST_21632747_ChIP-Seq_MESCs_Mouse1.18058963
67RNF2_18974828_ChIP-Seq_MESCs_Mouse1.12225351
68EZH2_18974828_ChIP-Seq_MESCs_Mouse1.12225351
69GATA1_26923725_Chip-Seq_HPCs_Mouse1.12090547
70MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.11697610
71BCL6_27268052_Chip-Seq_Bcells_Human1.09203233
72MYC_18940864_ChIP-ChIP_HL60_Human1.08919856
73CTCF_20526341_ChIP-Seq_ESCs_Human1.08501381
74TP53_20018659_ChIP-ChIP_R1E_Mouse1.08077770
75FOXP3_21729870_ChIP-Seq_TREG_Human1.07431045
76RBPJ_22232070_ChIP-Seq_NCS_Mouse1.05862033
77TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.05748615
78VDR_23849224_ChIP-Seq_CD4+_Human1.05642409
79SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.05249502
80NELFA_20434984_ChIP-Seq_ESCs_Mouse1.03881834
81LXR_22292898_ChIP-Seq_THP-1_Human1.02146974
82CTCF_26484167_Chip-Seq_Bcells_Mouse1.01702819
83YY1_22570637_ChIP-Seq_MALME-3M_Human1.01051885
84CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00506971
85EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.00024548
86E2F1_20622854_ChIP-Seq_HELA_Human0.99476970
87SA1_27219007_Chip-Seq_ERYTHROID_Human0.98861884
88MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.98055081
89SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97746000
90SRY_22984422_ChIP-ChIP_TESTIS_Rat0.96388579
91SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.95612767
92RNF2_27304074_Chip-Seq_ESCs_Mouse0.95110475
93BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94605836
94PHF8_20622854_ChIP-Seq_HELA_Human0.94398271
95OCT4_18692474_ChIP-Seq_MEFs_Mouse0.94302903
96MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.93503555
97SOX2_16153702_ChIP-ChIP_HESCs_Human0.93095301
98CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.92841632
99VDR_21846776_ChIP-Seq_THP-1_Human0.92673228
100ZFX_18555785_ChIP-Seq_MESCs_Mouse0.92560717

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.70537149
2MP0003122_maternal_imprinting3.24962585
3MP0003787_abnormal_imprinting2.90537490
4MP0009379_abnormal_foot_pigmentation2.70219783
5MP0001188_hyperpigmentation2.61804751
6MP0004859_abnormal_synaptic_plasticity2.57077507
7MP0003880_abnormal_central_pattern2.28023682
8MP0002653_abnormal_ependyma_morphology2.27381947
9MP0003121_genomic_imprinting2.18221722
10MP0008789_abnormal_olfactory_epithelium2.11304650
11MP0001968_abnormal_touch/_nociception2.10204113
12MP0005394_taste/olfaction_phenotype2.06684903
13MP0005499_abnormal_olfactory_system2.06684903
14MP0003123_paternal_imprinting2.06261540
15MP0002234_abnormal_pharynx_morphology2.03564395
16MP0005645_abnormal_hypothalamus_physiol2.03313441
17MP0005423_abnormal_somatic_nervous2.02250802
18MP0006276_abnormal_autonomic_nervous2.00799762
19MP0004145_abnormal_muscle_electrophysio1.92016042
20MP0005646_abnormal_pituitary_gland1.89755108
21MP0000049_abnormal_middle_ear1.85319832
22MP0002822_catalepsy1.83051895
23MP0002163_abnormal_gland_morphology1.82821559
24MP0010030_abnormal_orbit_morphology1.82121941
25MP0003635_abnormal_synaptic_transmissio1.75464758
26MP0004133_heterotaxia1.74797634
27MP0002733_abnormal_thermal_nociception1.67236496
28MP0009745_abnormal_behavioral_response1.62159289
29MP0002102_abnormal_ear_morphology1.62048666
30MP0002063_abnormal_learning/memory/cond1.60614866
31MP0002249_abnormal_larynx_morphology1.57990482
32MP0002272_abnormal_nervous_system1.54589306
33MP0002064_seizures1.54445934
34MP0004885_abnormal_endolymph1.54276390
35MP0002938_white_spotting1.52984684
36MP0000678_abnormal_parathyroid_gland1.52793937
37MP0004142_abnormal_muscle_tone1.48062067
38MP0000778_abnormal_nervous_system1.46841870
39MP0002557_abnormal_social/conspecific_i1.46435566
40MP0001529_abnormal_vocalization1.44729867
41MP0001905_abnormal_dopamine_level1.40657232
42MP0002736_abnormal_nociception_after1.39590013
43MP0008932_abnormal_embryonic_tissue1.38104773
44MP0002572_abnormal_emotion/affect_behav1.37275940
45MP0004147_increased_porphyrin_level1.36819828
46MP0001293_anophthalmia1.36373971
47MP0003693_abnormal_embryo_hatching1.36151407
48MP0004858_abnormal_nervous_system1.36110535
49MP0001984_abnormal_olfaction1.32577217
50MP0001970_abnormal_pain_threshold1.31379255
51MP0009046_muscle_twitch1.30512258
52MP0000631_abnormal_neuroendocrine_gland1.30336202
53MP0000955_abnormal_spinal_cord1.29961513
54MP0002735_abnormal_chemical_nociception1.25395946
55MP0001502_abnormal_circadian_rhythm1.23126471
56MP0002184_abnormal_innervation1.22813703
57MP0002734_abnormal_mechanical_nocicepti1.22306349
58MP0005187_abnormal_penis_morphology1.20302776
59MP0008877_abnormal_DNA_methylation1.17782710
60MP0001486_abnormal_startle_reflex1.16000298
61MP0002160_abnormal_reproductive_system1.13631557
62MP0001440_abnormal_grooming_behavior1.11605483
63MP0003942_abnormal_urinary_system1.09881441
64MP0003938_abnormal_ear_development1.09855761
65MP0008995_early_reproductive_senescence1.08671545
66MP0002882_abnormal_neuron_morphology1.05926761
67MP0003119_abnormal_digestive_system1.03494398
68MP0003385_abnormal_body_wall1.02980901
69MP0000026_abnormal_inner_ear1.00593862
70MP0002752_abnormal_somatic_nervous1.00049028
71MP0002067_abnormal_sensory_capabilities0.99793302
72MP0003186_abnormal_redox_activity0.97908702
73MP0004742_abnormal_vestibular_system0.95940267
74MP0005377_hearing/vestibular/ear_phenot0.95418366
75MP0003878_abnormal_ear_physiology0.95418366
76MP0009278_abnormal_bone_marrow0.94292664
77MP0002152_abnormal_brain_morphology0.93457541
78MP0002095_abnormal_skin_pigmentation0.92064669
79MP0003011_delayed_dark_adaptation0.92040290
80MP0004811_abnormal_neuron_physiology0.91906342
81MP0006035_abnormal_mitochondrial_morpho0.90913646
82MP0008872_abnormal_physiological_respon0.88076411
83MP0002638_abnormal_pupillary_reflex0.86763827
84MP0008058_abnormal_DNA_repair0.86276001
85MP0003861_abnormal_nervous_system0.86103575
86MP0001963_abnormal_hearing_physiology0.83430052
87MP0000681_abnormal_thyroid_gland0.82214168
88MP0006036_abnormal_mitochondrial_physio0.81534735
89MP0003879_abnormal_hair_cell0.80582246
90MP0003136_yellow_coat_color0.80376738
91MP0005379_endocrine/exocrine_gland_phen0.79882587
92MP0005551_abnormal_eye_electrophysiolog0.79031641
93MP0000566_synostosis0.78372290
94MP0005389_reproductive_system_phenotype0.78213693
95MP0006072_abnormal_retinal_apoptosis0.78037718
96MP0003315_abnormal_perineum_morphology0.77796607
97MP0000372_irregular_coat_pigmentation0.76417556
98MP0002066_abnormal_motor_capabilities/c0.75913505
99MP0001270_distended_abdomen0.73550752
100MP0002210_abnormal_sex_determination0.72477477

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.69238458
2Abnormal mitochondria in muscle tissue (HP:0008316)4.56954495
3Myokymia (HP:0002411)4.24469903
4Abnormality of cells of the erythroid lineage (HP:0012130)4.09799017
5Acute encephalopathy (HP:0006846)4.03041902
6Mitochondrial inheritance (HP:0001427)4.00862320
7Abnormal number of erythroid precursors (HP:0012131)3.80550016
83-Methylglutaconic aciduria (HP:0003535)3.69949447
9Progressive macrocephaly (HP:0004481)3.67677653
10Hyperthyroidism (HP:0000836)3.57009265
11Increased CSF lactate (HP:0002490)3.49997873
12Hepatocellular necrosis (HP:0001404)3.48005701
13Reticulocytopenia (HP:0001896)3.46553872
14Truncus arteriosus (HP:0001660)3.37786410
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.10580011
16Decreased activity of mitochondrial respiratory chain (HP:0008972)3.10580011
17Cerebral edema (HP:0002181)2.98181289
18Congenital malformation of the right heart (HP:0011723)2.95999495
19Double outlet right ventricle (HP:0001719)2.95999495
20Hepatic necrosis (HP:0002605)2.95545150
21Rib fusion (HP:0000902)2.73594421
22Macrocytic anemia (HP:0001972)2.67324385
23Cerebral hypomyelination (HP:0006808)2.66929693
24Increased intramyocellular lipid droplets (HP:0012240)2.61842719
25Pallor (HP:0000980)2.59290486
26Pancreatic fibrosis (HP:0100732)2.58953774
27Muscle fiber atrophy (HP:0100295)2.57315109
28Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.53279400
29Increased hepatocellular lipid droplets (HP:0006565)2.50880709
30Broad distal phalanx of finger (HP:0009836)2.49625627
31Lactic acidosis (HP:0003128)2.44408850
32Colon cancer (HP:0003003)2.44229575
33Gait imbalance (HP:0002141)2.42976569
34Abnormality of the aortic arch (HP:0012303)2.38885720
35CNS hypomyelination (HP:0003429)2.37528021
36Aplasia/Hypoplasia of the sacrum (HP:0008517)2.33584386
37Type 2 muscle fiber atrophy (HP:0003554)2.33432571
38Sclerocornea (HP:0000647)2.30656378
39Respiratory failure (HP:0002878)2.29354459
40Microvesicular hepatic steatosis (HP:0001414)2.26280331
41Abnormality of the labia minora (HP:0012880)2.24332412
42Increased serum lactate (HP:0002151)2.24195454
43Molar tooth sign on MRI (HP:0002419)2.22874474
44Abnormality of midbrain morphology (HP:0002418)2.22874474
45Medial flaring of the eyebrow (HP:0010747)2.22371678
46Optic disc pallor (HP:0000543)2.21800684
47Microretrognathia (HP:0000308)2.21055171
48Leukodystrophy (HP:0002415)2.20958552
49Lipid accumulation in hepatocytes (HP:0006561)2.20352969
50Congenital primary aphakia (HP:0007707)2.20141830
51Abnormal number of incisors (HP:0011064)2.19628634
52Increased muscle lipid content (HP:0009058)2.17161772
53Exercise intolerance (HP:0003546)2.16864939
54Renal Fanconi syndrome (HP:0001994)2.14142036
55Emotional lability (HP:0000712)2.13187121
56Polyphagia (HP:0002591)2.12547642
57True hermaphroditism (HP:0010459)2.12287660
58Epileptic encephalopathy (HP:0200134)2.11767612
59Abnormality of cochlea (HP:0000375)2.09688101
60Anomalous pulmonary venous return (HP:0010772)2.04437831
61Septo-optic dysplasia (HP:0100842)2.02050394
62X-linked dominant inheritance (HP:0001423)2.00717080
63Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.97917887
64Depressed nasal ridge (HP:0000457)1.97695964
65Nephrogenic diabetes insipidus (HP:0009806)1.95427415
66Anophthalmia (HP:0000528)1.91703437
67Pancreatic cysts (HP:0001737)1.90142109
68Abnormality of DNA repair (HP:0003254)1.89670854
69Nephronophthisis (HP:0000090)1.88871342
70Methylmalonic aciduria (HP:0012120)1.87582681
71Stenosis of the external auditory canal (HP:0000402)1.86633835
72Oligodactyly (HP:0012165)1.85499604
73Horseshoe kidney (HP:0000085)1.83272965
74Optic nerve coloboma (HP:0000588)1.81293343
75Type II lissencephaly (HP:0007260)1.81232791
76Anencephaly (HP:0002323)1.80278556
77Abnormal hemoglobin (HP:0011902)1.79626166
78Hyperglycinemia (HP:0002154)1.78405130
79Lethargy (HP:0001254)1.78121714
80Abnormality of reticulocytes (HP:0004312)1.76150667
81Occipital encephalocele (HP:0002085)1.74384944
82Methylmalonic acidemia (HP:0002912)1.73721515
83Adrenal hypoplasia (HP:0000835)1.71582825
84Aplasia/Hypoplasia of the patella (HP:0006498)1.71570656
85Aganglionic megacolon (HP:0002251)1.71385507
86Abnormality of magnesium homeostasis (HP:0004921)1.71023396
87Morphological abnormality of the inner ear (HP:0011390)1.69125793
88Maternal diabetes (HP:0009800)1.68907152
89Specific learning disability (HP:0001328)1.68598524
90Lissencephaly (HP:0001339)1.68479034
91Down-sloping shoulders (HP:0200021)1.67829894
92Ulnar claw (HP:0001178)1.67025290
93Abnormality of the pulmonary veins (HP:0011718)1.65976999
94Hypoplastic left heart (HP:0004383)1.65137865
95Patellar aplasia (HP:0006443)1.64984994
96Poor suck (HP:0002033)1.63531372
97Hypoparathyroidism (HP:0000829)1.62543581
98Retinal dysplasia (HP:0007973)1.60865567
99Delusions (HP:0000746)1.60146144
100Vaginal atresia (HP:0000148)1.59289503

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.25371695
2BCKDK3.92935733
3STK162.97663532
4MAP2K72.61295792
5MAP3K42.41432054
6DYRK22.38900004
7ADRBK22.24150160
8CDC72.14799323
9MAP4K22.05165113
10PLK41.99603413
11EPHA41.89450045
12NTRK21.87838544
13BRAF1.84213538
14TESK21.83503760
15PAK61.64717276
16CASK1.62421629
17VRK21.59949210
18GRK11.52817753
19PINK11.52154809
20AURKA1.49933200
21KDR1.46293067
22CSNK1G31.44812140
23CDK191.40467772
24DYRK31.40097411
25MARK11.36794662
26CDK81.36475715
27PRKD31.36415310
28NTRK31.32944568
29WNK31.26931731
30PDK21.23444881
31PRKCG1.21520481
32CSNK1G21.20475183
33LRRK21.16684092
34MAP3K111.13052899
35LIMK11.09684656
36CSNK1A1L1.07661126
37CAMKK21.06912348
38DYRK1B1.05374937
39ARAF1.04998544
40ABL21.04473689
41BUB11.02689021
42CSNK1G10.99347516
43PIM20.98440351
44TLK10.96328951
45MAP2K40.95874903
46MAPK130.95114458
47RPS6KA50.92962842
48CDK11A0.88197384
49CDK140.86991380
50BRSK10.86546908
51UHMK10.86264309
52NME10.84852689
53CDK150.84162902
54TIE10.81367387
55VRK10.81020350
56MAP2K20.80398932
57SIK20.79902724
58CAMKK10.78655166
59MINK10.77988041
60CAMK10.77751316
61SGK2230.77644565
62SGK4940.77644565
63MAP3K90.76805752
64CDK180.76758922
65CHEK20.75943115
66PKN10.74578545
67GRK50.74153303
68NTRK10.73307691
69NUAK10.70119190
70ATR0.66470166
71CAMK40.65909348
72PLK10.65154372
73CSNK2A20.64893070
74AURKB0.63096011
75AKT30.60346139
76ADRBK10.59361030
77INSRR0.58986573
78AKT20.57933633
79WNK40.57076717
80CSNK2A10.55656877
81SRPK10.55583692
82CDK50.55006352
83PLK20.54334693
84ZAK0.54072763
85RPS6KA40.52812185
86CAMK2G0.52791300
87CAMK2B0.52255982
88DYRK1A0.52072610
89TYRO30.51728756
90STK110.50534688
91EPHB20.49707617
92CSNK1E0.49090722
93PRKCI0.47895684
94PAK30.46810617
95NEK10.44204170
96PAK10.43971831
97PRKACA0.43803191
98CAMK2A0.42200604
99RPS6KA20.42181456
100CSNK1A10.41916173

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.36691031
2Oxidative phosphorylation_Homo sapiens_hsa001904.42250161
3Parkinsons disease_Homo sapiens_hsa050123.75444087
4Sulfur relay system_Homo sapiens_hsa041223.07536114
5Huntingtons disease_Homo sapiens_hsa050162.74781187
6RNA polymerase_Homo sapiens_hsa030202.71771657
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.70352269
8Alzheimers disease_Homo sapiens_hsa050102.63135728
9Cardiac muscle contraction_Homo sapiens_hsa042602.48983128
10DNA replication_Homo sapiens_hsa030302.40571255
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.28694930
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.25812671
13Base excision repair_Homo sapiens_hsa034102.13813943
14Mismatch repair_Homo sapiens_hsa034302.07565717
15Fanconi anemia pathway_Homo sapiens_hsa034602.01819918
16Pyrimidine metabolism_Homo sapiens_hsa002401.99564423
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.69582596
18Folate biosynthesis_Homo sapiens_hsa007901.60046019
19One carbon pool by folate_Homo sapiens_hsa006701.59636001
20Synaptic vesicle cycle_Homo sapiens_hsa047211.51271768
21Steroid biosynthesis_Homo sapiens_hsa001001.50964310
22Homologous recombination_Homo sapiens_hsa034401.46974568
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.42194216
24Nicotine addiction_Homo sapiens_hsa050331.39801686
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.32594926
26Phenylalanine metabolism_Homo sapiens_hsa003601.28931165
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20562419
28Spliceosome_Homo sapiens_hsa030401.16802320
29Purine metabolism_Homo sapiens_hsa002301.15801665
30Nucleotide excision repair_Homo sapiens_hsa034201.12269535
31Phototransduction_Homo sapiens_hsa047441.09975674
32Proteasome_Homo sapiens_hsa030501.05182975
33Fatty acid elongation_Homo sapiens_hsa000621.00351991
34Collecting duct acid secretion_Homo sapiens_hsa049660.99005061
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.96388049
36Basal cell carcinoma_Homo sapiens_hsa052170.92678057
37Cyanoamino acid metabolism_Homo sapiens_hsa004600.90187371
38Vitamin B6 metabolism_Homo sapiens_hsa007500.89247394
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86706854
40RNA degradation_Homo sapiens_hsa030180.86205238
41Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.83975538
42Biosynthesis of amino acids_Homo sapiens_hsa012300.83838211
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83554670
44RNA transport_Homo sapiens_hsa030130.83116142
45Protein export_Homo sapiens_hsa030600.81906911
46Pyruvate metabolism_Homo sapiens_hsa006200.81271017
47Metabolic pathways_Homo sapiens_hsa011000.81110026
48GABAergic synapse_Homo sapiens_hsa047270.79372437
49Peroxisome_Homo sapiens_hsa041460.76906052
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74548776
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69200133
52Morphine addiction_Homo sapiens_hsa050320.68559324
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67678618
54Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.67165008
55Glutathione metabolism_Homo sapiens_hsa004800.65326773
56Alcoholism_Homo sapiens_hsa050340.65003556
57Tyrosine metabolism_Homo sapiens_hsa003500.63663211
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.62732404
59Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.60945704
60Arginine and proline metabolism_Homo sapiens_hsa003300.56741605
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56307260
62Glutamatergic synapse_Homo sapiens_hsa047240.56039915
63Cocaine addiction_Homo sapiens_hsa050300.54290439
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54225702
65Hedgehog signaling pathway_Homo sapiens_hsa043400.53945338
66Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.50567946
67Insulin secretion_Homo sapiens_hsa049110.48688498
68Carbon metabolism_Homo sapiens_hsa012000.47788255
69Propanoate metabolism_Homo sapiens_hsa006400.47708672
70Dopaminergic synapse_Homo sapiens_hsa047280.47411367
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46128025
72Regulation of autophagy_Homo sapiens_hsa041400.43615966
73Circadian entrainment_Homo sapiens_hsa047130.43060364
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42805050
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41230868
76Taste transduction_Homo sapiens_hsa047420.40623305
77Olfactory transduction_Homo sapiens_hsa047400.40523956
78Sulfur metabolism_Homo sapiens_hsa009200.40298733
79Vibrio cholerae infection_Homo sapiens_hsa051100.39903698
80Hippo signaling pathway_Homo sapiens_hsa043900.37548081
81Basal transcription factors_Homo sapiens_hsa030220.36712301
82Butanoate metabolism_Homo sapiens_hsa006500.35220923
83Notch signaling pathway_Homo sapiens_hsa043300.34619375
84Cholinergic synapse_Homo sapiens_hsa047250.30617547
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29040543
86Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.28952576
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.28439383
88Axon guidance_Homo sapiens_hsa043600.25501424
89Wnt signaling pathway_Homo sapiens_hsa043100.24258650
90Melanogenesis_Homo sapiens_hsa049160.22081506
91Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.21540425
92Amphetamine addiction_Homo sapiens_hsa050310.21077306
93Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.20628400
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.18890872
95Pentose phosphate pathway_Homo sapiens_hsa000300.18829138
96beta-Alanine metabolism_Homo sapiens_hsa004100.18786034
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.18319322
98Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.17864682
99Cell cycle_Homo sapiens_hsa041100.17747695
100Tryptophan metabolism_Homo sapiens_hsa003800.17233123

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