C19ORF73

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein complex biogenesis (GO:0070271)5.55939996
2respiratory chain complex IV assembly (GO:0008535)5.30893732
3cytochrome complex assembly (GO:0017004)5.22217623
4deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.18114886
5mitochondrial respiratory chain complex assembly (GO:0033108)5.17963473
6pyrimidine deoxyribonucleotide catabolic process (GO:0009223)5.13060212
7viral transcription (GO:0019083)4.95114548
8peptidyl-histidine modification (GO:0018202)4.92617324
9metallo-sulfur cluster assembly (GO:0031163)4.86347834
10iron-sulfur cluster assembly (GO:0016226)4.86347834
11translational termination (GO:0006415)4.77772549
12mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.59353820
13mitochondrial respiratory chain complex I assembly (GO:0032981)4.59353820
14NADH dehydrogenase complex assembly (GO:0010257)4.59353820
15ribosomal small subunit biogenesis (GO:0042274)4.41799480
16mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.30027069
17SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.26354385
18tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.24324254
19RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.24324254
20negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)4.20827481
21cotranslational protein targeting to membrane (GO:0006613)4.20681832
22deoxyribonucleotide catabolic process (GO:0009264)4.17106044
23translational elongation (GO:0006414)4.13914278
24pyrimidine nucleotide catabolic process (GO:0006244)4.11922584
25protein targeting to ER (GO:0045047)4.11428414
26ATP synthesis coupled proton transport (GO:0015986)4.10949462
27energy coupled proton transport, down electrochemical gradient (GO:0015985)4.10949462
28deoxyribose phosphate catabolic process (GO:0046386)4.05195323
29regulation of mitochondrial translation (GO:0070129)4.02550230
30respiratory electron transport chain (GO:0022904)3.99859645
31protein localization to endoplasmic reticulum (GO:0070972)3.99691551
32electron transport chain (GO:0022900)3.98666026
33mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.98483286
34establishment of protein localization to endoplasmic reticulum (GO:0072599)3.94653848
35ribosomal small subunit assembly (GO:0000028)3.94052995
36maturation of SSU-rRNA (GO:0030490)3.90224436
37base-excision repair, AP site formation (GO:0006285)3.88895811
38viral life cycle (GO:0019058)3.77142823
39negative regulation of DNA-templated transcription, elongation (GO:0032785)3.74020313
40cellular protein complex disassembly (GO:0043624)3.65600592
41protein neddylation (GO:0045116)3.62433538
42nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.54374761
43oxidative phosphorylation (GO:0006119)3.53281345
44nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.51438575
45seminiferous tubule development (GO:0072520)3.46522072
46protein-cofactor linkage (GO:0018065)3.43991421
47pseudouridine synthesis (GO:0001522)3.42698346
48purine deoxyribonucleotide catabolic process (GO:0009155)3.40870098
49chaperone-mediated protein transport (GO:0072321)3.39252405
50translational initiation (GO:0006413)3.33255224
51translation (GO:0006412)3.28920626
52L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.19932082
53protein targeting to mitochondrion (GO:0006626)3.18395794
54exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.17442451
55DNA deamination (GO:0045006)3.17420444
56protein complex disassembly (GO:0043241)3.16624635
57adaptation of signaling pathway (GO:0023058)3.16134151
58establishment of protein localization to mitochondrion (GO:0072655)3.12386430
59water-soluble vitamin biosynthetic process (GO:0042364)3.12336863
60synaptic transmission, dopaminergic (GO:0001963)3.11202481
61branched-chain amino acid catabolic process (GO:0009083)3.10481366
62protein maturation by protein folding (GO:0022417)3.04452733
63biotin metabolic process (GO:0006768)3.01556698
64hydrogen ion transmembrane transport (GO:1902600)2.98647499
65macromolecular complex disassembly (GO:0032984)2.98043762
66cellular component biogenesis (GO:0044085)2.96421143
67positive regulation of TOR signaling (GO:0032008)2.95875543
68ATP biosynthetic process (GO:0006754)2.93996347
69regulation of hexokinase activity (GO:1903299)2.92405186
70regulation of glucokinase activity (GO:0033131)2.92405186
71purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.92256173
72DNA damage response, detection of DNA damage (GO:0042769)2.91337976
73purine nucleoside triphosphate biosynthetic process (GO:0009145)2.87151858
74GTP biosynthetic process (GO:0006183)2.86745622
75nuclear-transcribed mRNA catabolic process (GO:0000956)2.86127565
76pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.83210429
77aldehyde catabolic process (GO:0046185)2.81472292
78protein localization to mitochondrion (GO:0070585)2.79411810
79proton transport (GO:0015992)2.77528250
80establishment of mitochondrion localization (GO:0051654)2.75873624
81tRNA processing (GO:0008033)2.75127703
82mRNA catabolic process (GO:0006402)2.71883689
83hydrogen transport (GO:0006818)2.71511850
84amyloid precursor protein catabolic process (GO:0042987)2.69902475
85mitochondrion transport along microtubule (GO:0047497)2.68115385
86establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.68115385
87energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.67635499
88ATP hydrolysis coupled proton transport (GO:0015991)2.67635499
89protein targeting to membrane (GO:0006612)2.64584926
90deoxyribose phosphate metabolic process (GO:0019692)2.63011337
912-deoxyribonucleotide metabolic process (GO:0009394)2.62998375
92pharyngeal system development (GO:0060037)2.61476743
93dorsal/ventral neural tube patterning (GO:0021904)2.59803215
94transcription elongation from RNA polymerase III promoter (GO:0006385)2.59701628
95termination of RNA polymerase III transcription (GO:0006386)2.59701628
96viral protein processing (GO:0019082)2.59654201
97response to misfolded protein (GO:0051788)2.58984759
98positive regulation of prostaglandin secretion (GO:0032308)2.58106790
99protein import into peroxisome matrix (GO:0016558)2.57778667
100nitric oxide mediated signal transduction (GO:0007263)2.57346481

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.32921102
2ELF1_17652178_ChIP-ChIP_JURKAT_Human3.90984234
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.79101012
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.65566781
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.47944291
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.45538421
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.31580376
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.26488976
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.90434663
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.78471512
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.64029263
12THAP11_20581084_ChIP-Seq_MESCs_Mouse2.61097699
13EZH2_22144423_ChIP-Seq_EOC_Human2.53282260
14PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.46997549
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.46062238
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.40771989
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.35410410
18CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.31116734
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.29223555
20XRN2_22483619_ChIP-Seq_HELA_Human2.23497800
21SRF_21415370_ChIP-Seq_HL-1_Mouse2.21067665
22VDR_23849224_ChIP-Seq_CD4+_Human2.17194188
23MYC_18940864_ChIP-ChIP_HL60_Human2.10334942
24GABP_19822575_ChIP-Seq_HepG2_Human2.07116776
25CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.06030485
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.01414541
27CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.99413927
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.94032768
29FOXP3_21729870_ChIP-Seq_TREG_Human1.92304595
30TTF2_22483619_ChIP-Seq_HELA_Human1.86210468
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.85340178
32YY1_21170310_ChIP-Seq_MESCs_Mouse1.85106390
33DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.84176806
34EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.81447447
35CIITA_25753668_ChIP-Seq_RAJI_Human1.66848789
36ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.63611970
37SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.61671388
38DCP1A_22483619_ChIP-Seq_HELA_Human1.58565052
39MYC_19030024_ChIP-ChIP_MESCs_Mouse1.56816981
40PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.56801401
41CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.52191687
42E2F1_18555785_ChIP-Seq_MESCs_Mouse1.51938110
43CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.48687478
44YY1_22570637_ChIP-Seq_MALME-3M_Human1.42600112
45SRY_22984422_ChIP-ChIP_TESTIS_Rat1.39842344
46* FOXP1_21924763_ChIP-Seq_HESCs_Human1.39651123
47SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.38926017
48ZNF274_21170338_ChIP-Seq_K562_Hela1.36445386
49ELK1_19687146_ChIP-ChIP_HELA_Human1.35979041
50ERA_21632823_ChIP-Seq_H3396_Human1.35911482
51BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.35861624
52CTCF_18555785_ChIP-Seq_MESCs_Mouse1.35812277
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33878382
54EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.32613253
55TET1_21451524_ChIP-Seq_MESCs_Mouse1.32568203
56TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30137631
57BCL6_27268052_Chip-Seq_Bcells_Human1.29283036
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27439628
59CBX2_27304074_Chip-Seq_ESCs_Mouse1.27372006
60P68_20966046_ChIP-Seq_HELA_Human1.22521495
61FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.22146987
62E2F1_20622854_ChIP-Seq_HELA_Human1.21130662
63MYC_19079543_ChIP-ChIP_MESCs_Mouse1.18371118
64BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17077416
65* TAF2_19829295_ChIP-Seq_ESCs_Human1.17044715
66KDM5A_27292631_Chip-Seq_BREAST_Human1.15959064
67POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.15392048
68RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.13849159
69DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13193690
70HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12503174
71PHF8_20622854_ChIP-Seq_HELA_Human1.11140938
72ELF1_20517297_ChIP-Seq_JURKAT_Human1.10930593
73ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.10895633
74SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.08783594
75PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.06290127
76TP53_22573176_ChIP-Seq_HFKS_Human1.06246753
77NELFA_20434984_ChIP-Seq_ESCs_Mouse1.05126532
78CTCF_26484167_Chip-Seq_Bcells_Mouse1.04601611
79BCOR_27268052_Chip-Seq_Bcells_Human1.04434850
80ERG_20887958_ChIP-Seq_HPC-7_Mouse1.04003472
81MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.03629433
82POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03344637
83CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.03040455
84CTCF_20526341_ChIP-Seq_ESCs_Human1.00067454
85RARB_24833708_ChIP-Seq_LIVER_Mouse0.98411104
86YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97793138
87MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.96208298
88SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.96088639
89EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95000454
90KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.93700212
91CTCF_21964334_Chip-Seq_Bcells_Human0.93694811
92PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92793985
93TP63_19390658_ChIP-ChIP_HaCaT_Human0.91536618
94IRF1_19129219_ChIP-ChIP_H3396_Human0.89213442
95NOTCH1_21737748_ChIP-Seq_TLL_Human0.89100729
96RAC3_21632823_ChIP-Seq_H3396_Human0.86377501
97REST_18959480_ChIP-ChIP_MESCs_Mouse0.86200416
98* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85809230
99ZFX_18555785_ChIP-Seq_MESCs_Mouse0.85479637
100P300_27268052_Chip-Seq_Bcells_Human0.85474867

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy3.57209102
2MP0001905_abnormal_dopamine_level2.69867797
3MP0002163_abnormal_gland_morphology2.58060289
4MP0005423_abnormal_somatic_nervous2.52540314
5MP0002837_dystrophic_cardiac_calcinosis2.32536449
6MP0001986_abnormal_taste_sensitivity2.29764831
7MP0005084_abnormal_gallbladder_morpholo2.18582193
8MP0001661_extended_life_span2.13944524
9MP0004147_increased_porphyrin_level2.11289955
10MP0005646_abnormal_pituitary_gland2.10290522
11MP0008058_abnormal_DNA_repair2.07171086
12MP0005379_endocrine/exocrine_gland_phen2.06076173
13MP0006276_abnormal_autonomic_nervous1.99723613
14MP0006072_abnormal_retinal_apoptosis1.97262297
15MP0001968_abnormal_touch/_nociception1.90783632
16MP0002909_abnormal_adrenal_gland1.88149321
17MP0006292_abnormal_olfactory_placode1.85999819
18MP0002638_abnormal_pupillary_reflex1.84801259
19MP0002234_abnormal_pharynx_morphology1.84309347
20MP0005451_abnormal_body_composition1.82334278
21MP0001529_abnormal_vocalization1.81458759
22MP0003186_abnormal_redox_activity1.76152490
23MP0003011_delayed_dark_adaptation1.75745974
24MP0000631_abnormal_neuroendocrine_gland1.70221027
25MP0003786_premature_aging1.69212992
26MP0002138_abnormal_hepatobiliary_system1.68850260
27MP0005645_abnormal_hypothalamus_physiol1.63712335
28MP0003195_calcinosis1.58566954
29MP0000678_abnormal_parathyroid_gland1.57934041
30MP0008877_abnormal_DNA_methylation1.56364461
31MP0002735_abnormal_chemical_nociception1.54110986
32MP0003787_abnormal_imprinting1.52943390
33MP0002277_abnormal_respiratory_mucosa1.52513316
34MP0001727_abnormal_embryo_implantation1.43148213
35MP0009745_abnormal_behavioral_response1.41258500
36MP0005220_abnormal_exocrine_pancreas1.39975128
37MP0004133_heterotaxia1.38523923
38MP0006036_abnormal_mitochondrial_physio1.34781045
39MP0002653_abnormal_ependyma_morphology1.34500310
40MP0002184_abnormal_innervation1.33695442
41MP0003122_maternal_imprinting1.33470130
42MP0005551_abnormal_eye_electrophysiolog1.32926226
43MP0002938_white_spotting1.32370503
44MP0002272_abnormal_nervous_system1.27901642
45MP0001502_abnormal_circadian_rhythm1.24665117
46MP0002249_abnormal_larynx_morphology1.23777233
47MP0005332_abnormal_amino_acid1.23735787
48MP0000049_abnormal_middle_ear1.23672764
49MP0003693_abnormal_embryo_hatching1.19706129
50MP0002160_abnormal_reproductive_system1.19396994
51MP0008872_abnormal_physiological_respon1.18153800
52MP0002572_abnormal_emotion/affect_behav1.17284525
53MP0005670_abnormal_white_adipose1.17148329
54MP0006035_abnormal_mitochondrial_morpho1.15901944
55MP0002102_abnormal_ear_morphology1.11899108
56MP0005408_hypopigmentation1.11123199
57MP0002557_abnormal_social/conspecific_i1.10112465
58MP0005253_abnormal_eye_physiology1.09356894
59MP0008875_abnormal_xenobiotic_pharmacok1.07755610
60MP0001764_abnormal_homeostasis1.05854293
61MP0003698_abnormal_male_reproductive1.05706630
62MP0002736_abnormal_nociception_after1.04685031
63MP0008995_early_reproductive_senescence1.01023462
64MP0003123_paternal_imprinting1.00447796
65MP0004924_abnormal_behavior0.99499374
66MP0005386_behavior/neurological_phenoty0.99499374
67MP0000470_abnormal_stomach_morphology0.98301426
68MP0005389_reproductive_system_phenotype0.98164025
69MP0002229_neurodegeneration0.96906725
70MP0005636_abnormal_mineral_homeostasis0.96769145
71MP0002693_abnormal_pancreas_physiology0.96655238
72MP0003121_genomic_imprinting0.95566423
73MP0002139_abnormal_hepatobiliary_system0.94475322
74MP0002734_abnormal_mechanical_nocicepti0.93286407
75MP0005075_abnormal_melanosome_morpholog0.92981411
76MP0008789_abnormal_olfactory_epithelium0.91753809
77MP0001984_abnormal_olfaction0.91652043
78MP0001145_abnormal_male_reproductive0.91156978
79MP0002063_abnormal_learning/memory/cond0.91041809
80MP0000372_irregular_coat_pigmentation0.89749244
81MP0002210_abnormal_sex_determination0.89531193
82MP0009379_abnormal_foot_pigmentation0.89142209
83MP0005499_abnormal_olfactory_system0.88986133
84MP0005394_taste/olfaction_phenotype0.88986133
85MP0002282_abnormal_trachea_morphology0.85566397
86MP0004142_abnormal_muscle_tone0.85380771
87MP0005266_abnormal_metabolism0.84927732
88MP0002132_abnormal_respiratory_system0.84451849
89MP0005367_renal/urinary_system_phenotyp0.83960587
90MP0000516_abnormal_urinary_system0.83960587
91MP0000639_abnormal_adrenal_gland0.83818819
92MP0001919_abnormal_reproductive_system0.83450375
93MP0004043_abnormal_pH_regulation0.82932776
94MP0001944_abnormal_pancreas_morphology0.82915753
95MP0002752_abnormal_somatic_nervous0.82297341
96MP0001929_abnormal_gametogenesis0.81238947
97MP0001756_abnormal_urination0.81067377
98MP0000653_abnormal_sex_gland0.80231163
99MP0003137_abnormal_impulse_conducting0.78229583
100MP0003718_maternal_effect0.78165931

Predicted human phenotypes

RankGene SetZ-score
1Hepatic necrosis (HP:0002605)4.70050551
2Hepatocellular necrosis (HP:0001404)4.50216808
3Abnormal mitochondria in muscle tissue (HP:0008316)4.28693259
4Mitochondrial inheritance (HP:0001427)4.27435826
5Acute necrotizing encephalopathy (HP:0006965)3.93462285
6Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.89217825
7Decreased activity of mitochondrial respiratory chain (HP:0008972)3.89217825
8Double outlet right ventricle (HP:0001719)3.85714261
9Congenital malformation of the right heart (HP:0011723)3.85714261
10Increased CSF lactate (HP:0002490)3.60621141
11Increased intramyocellular lipid droplets (HP:0012240)3.60539930
12Acute encephalopathy (HP:0006846)3.57342879
13Increased muscle lipid content (HP:0009058)3.31092586
14Progressive macrocephaly (HP:0004481)3.22391551
15Lipid accumulation in hepatocytes (HP:0006561)3.21524654
16Increased hepatocellular lipid droplets (HP:0006565)3.11647867
17Pancreatic fibrosis (HP:0100732)3.08030644
18Renal Fanconi syndrome (HP:0001994)2.97283291
19Lactic acidosis (HP:0003128)2.94346173
20Abnormality of midbrain morphology (HP:0002418)2.91777247
21Molar tooth sign on MRI (HP:0002419)2.91777247
22Hyperglycinemia (HP:0002154)2.88768118
23Sclerocornea (HP:0000647)2.85992815
24Abnormality of cells of the erythroid lineage (HP:0012130)2.79594161
25Reticulocytopenia (HP:0001896)2.77491083
26Abnormal number of erythroid precursors (HP:0012131)2.76753609
27Pancreatic cysts (HP:0001737)2.75216765
28Generalized aminoaciduria (HP:0002909)2.72338521
29Hypoglycemic coma (HP:0001325)2.71426543
30Ketosis (HP:0001946)2.54418487
31Tachypnea (HP:0002789)2.50264946
32Abnormality of urine glucose concentration (HP:0011016)2.47767086
33Glycosuria (HP:0003076)2.47767086
34Rib fusion (HP:0000902)2.46856864
35Cerebral edema (HP:0002181)2.43569975
36Cerebral palsy (HP:0100021)2.39991703
37Hyperthyroidism (HP:0000836)2.39501999
383-Methylglutaconic aciduria (HP:0003535)2.39364689
39Abnormality of the aortic arch (HP:0012303)2.38789368
40Tetany (HP:0001281)2.31965391
41Dicarboxylic aciduria (HP:0003215)2.31535920
42Abnormality of dicarboxylic acid metabolism (HP:0010995)2.31535920
43Abnormal biliary tract physiology (HP:0012439)2.28912009
44Bile duct proliferation (HP:0001408)2.28912009
45Increased serum lactate (HP:0002151)2.28006257
46Hyperventilation (HP:0002883)2.27678482
47Lethargy (HP:0001254)2.25309432
48Abnormality of the parathyroid morphology (HP:0011766)2.23864612
49Respiratory failure (HP:0002878)2.23446029
50Exercise intolerance (HP:0003546)2.19593237
51Hyperphosphaturia (HP:0003109)2.19534930
52Hypoglycemic seizures (HP:0002173)2.18352834
53Brushfield spots (HP:0001088)2.17665195
54True hermaphroditism (HP:0010459)2.17015931
55Cerebral hypomyelination (HP:0006808)2.16711772
56Type I transferrin isoform profile (HP:0003642)2.14098801
57Hypomagnesemia (HP:0002917)2.08125746
58Hyperinsulinemic hypoglycemia (HP:0000825)2.06574752
59Opisthotonus (HP:0002179)2.06201887
60Medial flaring of the eyebrow (HP:0010747)2.05363085
61Polyphagia (HP:0002591)2.02660832
62Methylmalonic acidemia (HP:0002912)2.01245973
63Abnormality of renal resorption (HP:0011038)2.00043523
64Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.97217345
65Abnormal protein N-linked glycosylation (HP:0012347)1.97217345
66Abnormal protein glycosylation (HP:0012346)1.97217345
67Abnormal glycosylation (HP:0012345)1.97217345
68Metabolic acidosis (HP:0001942)1.95647989
69Cystic liver disease (HP:0006706)1.94444638
70CNS hypomyelination (HP:0003429)1.93807006
71Abnormality of the line of Schwalbe (HP:0008048)1.92577327
72Neoplasm of the adrenal cortex (HP:0100641)1.91895633
73Abnormality of fatty-acid metabolism (HP:0004359)1.91858907
74Methylmalonic aciduria (HP:0012120)1.90690267
75Truncus arteriosus (HP:0001660)1.90506970
76Ragged-red muscle fibers (HP:0003200)1.89705150
77Exertional dyspnea (HP:0002875)1.87517826
78Symptomatic seizures (HP:0011145)1.86377389
79Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.86046242
80Posterior embryotoxon (HP:0000627)1.85897468
81Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.85437877
82Hypothermia (HP:0002045)1.84838286
83Nephronophthisis (HP:0000090)1.83061020
84Emotional lability (HP:0000712)1.81587322
85Macrocytic anemia (HP:0001972)1.81449334
86Muscular hypotonia of the trunk (HP:0008936)1.80720626
87Abnormality of magnesium homeostasis (HP:0004921)1.80538017
88Hypoalbuminemia (HP:0003073)1.80264478
89Abnormal albumin level (HP:0012116)1.80264478
90CNS demyelination (HP:0007305)1.78003117
91Prominent metopic ridge (HP:0005487)1.76747657
92Aplasia/Hypoplasia of the sacrum (HP:0008517)1.75296542
93Villous atrophy (HP:0011473)1.74110993
94Abnormality of small intestinal villus morphology (HP:0011472)1.74110993
95Abnormality of the metopic suture (HP:0005556)1.73483635
96Epiphyseal stippling (HP:0010655)1.72558705
97Renal cortical cysts (HP:0000803)1.71840549
98Facial shape deformation (HP:0011334)1.70381427
99Potter facies (HP:0002009)1.70381427
100Abnormality of DNA repair (HP:0003254)1.70339426

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK26.17302399
2BCKDK3.78412696
3BMPR1B3.09472319
4MUSK2.86441228
5ZAK2.85782549
6STK162.71403329
7MAPKAPK32.49657117
8MAP4K22.31054686
9PINK12.26569215
10CSNK1G32.21290728
11NUAK12.16177620
12MAPKAPK52.03128961
13MAP3K42.01618036
14NME11.97967230
15TAF11.96043168
16MAP3K111.95513817
17NME21.88016958
18CSNK1G11.85018620
19CSNK1G21.83962687
20DYRK21.79398639
21GRK11.79206549
22VRK11.74812715
23BUB11.68065403
24CSNK1A1L1.64358119
25FRK1.57891602
26MAP2K71.48916001
27SMG11.43064441
28EEF2K1.42375386
29IRAK31.40791286
30FLT31.35729631
31DAPK11.30456638
32WNK41.27192149
33ARAF1.21449036
34MAPK131.19461685
35DYRK31.17445933
36LRRK21.13986445
37AURKA1.06547893
38RPS6KA51.05709092
39PRKCI0.96405818
40TLK10.96258456
41ADRBK20.91076538
42STK390.90226711
43PIM20.89414498
44SRPK10.86801024
45GRK50.85613023
46TESK20.85004722
47CDK80.81852278
48RPS6KB20.81070832
49PLK10.79678410
50CHEK20.74370624
51NTRK20.73820125
52TGFBR10.72755192
53KDR0.70687557
54MAP2K60.64833606
55PRKCG0.63254096
56BRAF0.62142087
57PAK60.62091841
58MOS0.62072677
59IRAK20.61741817
60PASK0.59486219
61ABL20.59406968
62MAPK150.57125124
63MINK10.55800986
64DAPK30.54702174
65CDK70.52059381
66PLK40.51405827
67HIPK20.49115939
68PAK30.48625709
69CASK0.48249260
70PRKAA10.47375456
71DAPK20.45587245
72MAPK110.43478974
73CAMKK20.42844859
74WNK30.42164445
75PLK30.41331005
76CSNK1A10.41220389
77CSNK2A20.41040868
78LIMK10.39836949
79TRIM280.38321066
80MAP4K10.37653919
81STK110.35334901
82CAMKK10.34001423
83CDK11A0.33658077
84ADRBK10.33462170
85CAMK2D0.33431504
86AURKB0.32746725
87BRSK10.32297928
88CDK140.31636965
89RPS6KA40.31353879
90PRKD30.28392045
91ATR0.27936526
92CDK90.27337273
93CAMK2G0.27124288
94CDK150.26937550
95MAP2K40.26590653
96PRKACA0.25994664
97RPS6KA20.25005160
98FGFR20.24965918
99CSNK2A10.24848506
100CDK180.24604138

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.78042667
2Oxidative phosphorylation_Homo sapiens_hsa001904.26283374
3Parkinsons disease_Homo sapiens_hsa050123.51792022
4Sulfur relay system_Homo sapiens_hsa041223.09985039
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.57641489
6Base excision repair_Homo sapiens_hsa034102.50923516
7Huntingtons disease_Homo sapiens_hsa050162.49236488
8Alzheimers disease_Homo sapiens_hsa050102.44007513
9RNA polymerase_Homo sapiens_hsa030202.38023990
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.22523179
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.20525586
12Sulfur metabolism_Homo sapiens_hsa009202.16019992
13Maturity onset diabetes of the young_Homo sapiens_hsa049502.15515005
14Peroxisome_Homo sapiens_hsa041462.00220498
15Proteasome_Homo sapiens_hsa030501.90260036
16Cardiac muscle contraction_Homo sapiens_hsa042601.84790274
17RNA degradation_Homo sapiens_hsa030181.76710364
18Protein export_Homo sapiens_hsa030601.62811594
19Collecting duct acid secretion_Homo sapiens_hsa049661.52097099
20Pyrimidine metabolism_Homo sapiens_hsa002401.47581758
21DNA replication_Homo sapiens_hsa030301.46141894
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.41475123
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.40137976
24Homologous recombination_Homo sapiens_hsa034401.35513692
25Basal transcription factors_Homo sapiens_hsa030221.33835075
26Glycosaminoglycan degradation_Homo sapiens_hsa005311.32519254
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.32184150
28Purine metabolism_Homo sapiens_hsa002301.30247593
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.29039801
30Glutathione metabolism_Homo sapiens_hsa004801.28643753
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.25974396
32Regulation of autophagy_Homo sapiens_hsa041401.25519210
33Selenocompound metabolism_Homo sapiens_hsa004501.21353393
34Nucleotide excision repair_Homo sapiens_hsa034201.20732263
35Fatty acid elongation_Homo sapiens_hsa000621.17361593
36Folate biosynthesis_Homo sapiens_hsa007901.13209809
37Fanconi anemia pathway_Homo sapiens_hsa034601.12076404
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.11737020
39Pentose and glucuronate interconversions_Homo sapiens_hsa000401.09035018
40Mismatch repair_Homo sapiens_hsa034301.04739028
41Metabolic pathways_Homo sapiens_hsa011001.04145093
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.02042590
43Butanoate metabolism_Homo sapiens_hsa006501.01133890
44Phototransduction_Homo sapiens_hsa047441.00228498
45Cysteine and methionine metabolism_Homo sapiens_hsa002700.99233705
46Nitrogen metabolism_Homo sapiens_hsa009100.98918394
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93877969
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.89931617
49Primary bile acid biosynthesis_Homo sapiens_hsa001200.88227042
50Spliceosome_Homo sapiens_hsa030400.87363590
51Propanoate metabolism_Homo sapiens_hsa006400.84652274
52beta-Alanine metabolism_Homo sapiens_hsa004100.84473783
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.82729626
54Tryptophan metabolism_Homo sapiens_hsa003800.82304680
55Non-homologous end-joining_Homo sapiens_hsa034500.81530053
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80233180
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73741324
58N-Glycan biosynthesis_Homo sapiens_hsa005100.73690265
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72039746
60Basal cell carcinoma_Homo sapiens_hsa052170.69415406
61Synaptic vesicle cycle_Homo sapiens_hsa047210.68704783
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68112725
63Biosynthesis of amino acids_Homo sapiens_hsa012300.62282195
64Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.60397846
65Fatty acid metabolism_Homo sapiens_hsa012120.59296173
66Fatty acid degradation_Homo sapiens_hsa000710.58603795
67Arginine and proline metabolism_Homo sapiens_hsa003300.58335606
68Tyrosine metabolism_Homo sapiens_hsa003500.55945531
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55814259
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55171880
71RNA transport_Homo sapiens_hsa030130.54921823
72Primary immunodeficiency_Homo sapiens_hsa053400.53356086
73Chemical carcinogenesis_Homo sapiens_hsa052040.52290084
74One carbon pool by folate_Homo sapiens_hsa006700.51913111
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.50673430
76Nicotine addiction_Homo sapiens_hsa050330.46233192
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44026965
78Retinol metabolism_Homo sapiens_hsa008300.42994114
79Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.42344667
80Vibrio cholerae infection_Homo sapiens_hsa051100.41902675
81Insulin secretion_Homo sapiens_hsa049110.41666277
82Type I diabetes mellitus_Homo sapiens_hsa049400.41386036
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41112239
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.39782310
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39365444
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39359295
87Galactose metabolism_Homo sapiens_hsa000520.36273983
88ABC transporters_Homo sapiens_hsa020100.36246616
89Arachidonic acid metabolism_Homo sapiens_hsa005900.32601044
90Fructose and mannose metabolism_Homo sapiens_hsa000510.30236403
91Vitamin digestion and absorption_Homo sapiens_hsa049770.28235223
92Linoleic acid metabolism_Homo sapiens_hsa005910.27819350
93Oocyte meiosis_Homo sapiens_hsa041140.26729836
94Steroid biosynthesis_Homo sapiens_hsa001000.26658305
95Carbon metabolism_Homo sapiens_hsa012000.24778716
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.24593003
97Vitamin B6 metabolism_Homo sapiens_hsa007500.22819301
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.20427766
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.15509597
100Hedgehog signaling pathway_Homo sapiens_hsa043400.15148593

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