C19ORF44

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.98173562
2chaperone-mediated protein transport (GO:0072321)4.82380835
3axonemal dynein complex assembly (GO:0070286)4.79800454
4protein polyglutamylation (GO:0018095)4.68708540
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.56849206
6ATP synthesis coupled proton transport (GO:0015986)4.56849206
7mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.56752614
8mitochondrial respiratory chain complex I assembly (GO:0032981)4.56752614
9NADH dehydrogenase complex assembly (GO:0010257)4.56752614
10rRNA modification (GO:0000154)4.55814449
11rRNA methylation (GO:0031167)4.55119497
12epithelial cilium movement (GO:0003351)4.53037909
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.51724682
14protein complex biogenesis (GO:0070271)4.24652979
15microtubule depolymerization (GO:0007019)4.21929790
16mitochondrial respiratory chain complex assembly (GO:0033108)4.06034579
17cilium movement (GO:0003341)4.04476254
18regulation of cilium movement (GO:0003352)4.03307027
19sperm motility (GO:0030317)3.91866906
20viral transcription (GO:0019083)3.84806363
21translational termination (GO:0006415)3.72847119
22mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.67710380
23behavioral response to nicotine (GO:0035095)3.63195954
24axoneme assembly (GO:0035082)3.57922840
25cilium or flagellum-dependent cell motility (GO:0001539)3.56560088
26centriole replication (GO:0007099)3.55623818
27ribosomal small subunit biogenesis (GO:0042274)3.54344145
28response to pheromone (GO:0019236)3.50263041
29establishment of protein localization to mitochondrial membrane (GO:0090151)3.47810588
30ribosomal small subunit assembly (GO:0000028)3.37222168
31respiratory electron transport chain (GO:0022904)3.29544435
32electron transport chain (GO:0022900)3.28639704
33protein K6-linked ubiquitination (GO:0085020)3.24734215
34microtubule polymerization or depolymerization (GO:0031109)3.24374023
35SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.18408453
36translational elongation (GO:0006414)3.18403060
37maturation of SSU-rRNA (GO:0030490)3.17747640
38cotranslational protein targeting to membrane (GO:0006613)3.16208072
39spermatid development (GO:0007286)3.13655894
40motile cilium assembly (GO:0044458)3.10304682
41protein targeting to ER (GO:0045047)3.08191074
42DNA replication checkpoint (GO:0000076)3.07067992
43base-excision repair, AP site formation (GO:0006285)3.04889977
44negative regulation of telomere maintenance (GO:0032205)3.01740787
45acrosome reaction (GO:0007340)3.01426630
46multicellular organism reproduction (GO:0032504)2.95945247
47reciprocal meiotic recombination (GO:0007131)2.94921297
48reciprocal DNA recombination (GO:0035825)2.94921297
49cellular protein complex disassembly (GO:0043624)2.94304761
50pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.90552683
51piRNA metabolic process (GO:0034587)2.90029616
52establishment of protein localization to endoplasmic reticulum (GO:0072599)2.89688131
53water-soluble vitamin biosynthetic process (GO:0042364)2.89100510
54male meiosis I (GO:0007141)2.88225992
55pseudouridine synthesis (GO:0001522)2.87236569
56DNA replication-dependent nucleosome organization (GO:0034723)2.86753648
57DNA replication-dependent nucleosome assembly (GO:0006335)2.86753648
58centriole assembly (GO:0098534)2.86576953
59regulation of DNA endoreduplication (GO:0032875)2.84426787
60protein-cofactor linkage (GO:0018065)2.83317298
61synapsis (GO:0007129)2.82485421
62protein neddylation (GO:0045116)2.82104507
63protein localization to endoplasmic reticulum (GO:0070972)2.81980705
64replication fork processing (GO:0031297)2.81619368
65cilium organization (GO:0044782)2.80266414
66tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.79804956
67RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.79804956
68transcription elongation from RNA polymerase III promoter (GO:0006385)2.78088615
69termination of RNA polymerase III transcription (GO:0006386)2.78088615
70regulation of mitochondrial translation (GO:0070129)2.77874216
71viral life cycle (GO:0019058)2.75559584
72intraciliary transport (GO:0042073)2.72114963
73peptidyl-histidine modification (GO:0018202)2.71976604
74histone exchange (GO:0043486)2.70842659
75regulation of centriole replication (GO:0046599)2.69614663
76cilium assembly (GO:0042384)2.69580650
77regulation of nuclear cell cycle DNA replication (GO:0033262)2.68911476
78preassembly of GPI anchor in ER membrane (GO:0016254)2.67618864
79regulation of meiosis I (GO:0060631)2.66752935
80single strand break repair (GO:0000012)2.66195042
81proteasome assembly (GO:0043248)2.65612651
82regulation of microtubule-based movement (GO:0060632)2.64959984
83respiratory chain complex IV assembly (GO:0008535)2.64683040
84chromatin remodeling at centromere (GO:0031055)2.63397525
85otic vesicle formation (GO:0030916)2.62673863
86translational initiation (GO:0006413)2.60709380
87tRNA processing (GO:0008033)2.60569727
88negative regulation of DNA-dependent DNA replication (GO:2000104)2.60528739
89DNA deamination (GO:0045006)2.59635747
90left/right pattern formation (GO:0060972)2.57454274
91tRNA modification (GO:0006400)2.56768913
92nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.56672249
93ubiquinone biosynthetic process (GO:0006744)2.55512005
94recombinational repair (GO:0000725)2.54925818
95intracellular protein transmembrane import (GO:0044743)2.54779978
96protein complex disassembly (GO:0043241)2.54650399
97cellular component biogenesis (GO:0044085)2.54541487
98double-strand break repair via homologous recombination (GO:0000724)2.54470160
99cellular ketone body metabolic process (GO:0046950)2.54267807
100nucleoside transmembrane transport (GO:1901642)2.52729512

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.80422210
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.37105512
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.28507197
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.13616002
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.10684372
6ZNF274_21170338_ChIP-Seq_K562_Hela3.01638013
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.96755431
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.58504222
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.56860568
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.44169132
11VDR_22108803_ChIP-Seq_LS180_Human2.25813953
12EZH2_22144423_ChIP-Seq_EOC_Human2.23350137
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.16592573
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.06678990
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.00614660
16VDR_23849224_ChIP-Seq_CD4+_Human1.91041041
17EWS_26573619_Chip-Seq_HEK293_Human1.90524141
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.88401587
19EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.84659321
20FUS_26573619_Chip-Seq_HEK293_Human1.82836883
21MYC_18940864_ChIP-ChIP_HL60_Human1.71191219
22NOTCH1_21737748_ChIP-Seq_TLL_Human1.70134256
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.69202022
24MYC_18555785_ChIP-Seq_MESCs_Mouse1.68055896
25CBX2_27304074_Chip-Seq_ESCs_Mouse1.67465725
26E2F4_17652178_ChIP-ChIP_JURKAT_Human1.66864013
27BMI1_23680149_ChIP-Seq_NPCS_Mouse1.64437585
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.61574943
29TTF2_22483619_ChIP-Seq_HELA_Human1.61552712
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.59251509
31ELK1_19687146_ChIP-ChIP_HELA_Human1.57131537
32POU5F1_16153702_ChIP-ChIP_HESCs_Human1.51986490
33YY1_21170310_ChIP-Seq_MESCs_Mouse1.50759506
34CREB1_15753290_ChIP-ChIP_HEK293T_Human1.46750286
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45109163
36CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.44566721
37TP63_19390658_ChIP-ChIP_HaCaT_Human1.40872397
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.40213265
39SRF_21415370_ChIP-Seq_HL-1_Mouse1.37475443
40FOXP3_21729870_ChIP-Seq_TREG_Human1.37390380
41GABP_19822575_ChIP-Seq_HepG2_Human1.36670519
42XRN2_22483619_ChIP-Seq_HELA_Human1.36331663
43TP53_22573176_ChIP-Seq_HFKS_Human1.35844163
44GBX2_23144817_ChIP-Seq_PC3_Human1.35543493
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33966732
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33001376
47ER_23166858_ChIP-Seq_MCF-7_Human1.31875642
48ERA_21632823_ChIP-Seq_H3396_Human1.30863923
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29666931
50POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29539619
51IRF1_19129219_ChIP-ChIP_H3396_Human1.29377347
52MYC_18358816_ChIP-ChIP_MESCs_Mouse1.24320413
53TAF15_26573619_Chip-Seq_HEK293_Human1.21412964
54FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.21367324
55RNF2_27304074_Chip-Seq_NSC_Mouse1.20675568
56DCP1A_22483619_ChIP-Seq_HELA_Human1.19418774
57CBP_20019798_ChIP-Seq_JUKART_Human1.17420527
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17420527
59EED_16625203_ChIP-ChIP_MESCs_Mouse1.16919909
60GATA3_21878914_ChIP-Seq_MCF-7_Human1.16879468
61SALL1_21062744_ChIP-ChIP_HESCs_Human1.16714962
62* ETV2_25802403_ChIP-Seq_MESCs_Mouse1.15877676
63TDRD3_21172665_ChIP-Seq_MCF-7_Human1.14600557
64MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.13419640
65THAP11_20581084_ChIP-Seq_MESCs_Mouse1.13414173
66HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.13356271
67SOX2_16153702_ChIP-ChIP_HESCs_Human1.12939229
68P300_19829295_ChIP-Seq_ESCs_Human1.12419421
69EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.10873279
70ZFP57_27257070_Chip-Seq_ESCs_Mouse1.10648004
71* NCOR_22424771_ChIP-Seq_293T_Human1.09803831
72SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.08929814
73HOXB7_26014856_ChIP-Seq_BT474_Human1.08339359
74PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.07968143
75PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06286432
76EZH2_27304074_Chip-Seq_ESCs_Mouse1.04539719
77MYC_19829295_ChIP-Seq_ESCs_Human1.03890487
78RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.03599782
79CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.03200324
80NANOG_20526341_ChIP-Seq_ESCs_Human1.03149063
81TAF2_19829295_ChIP-Seq_ESCs_Human1.02379949
82EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.00831342
83SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00239473
84IGF1R_20145208_ChIP-Seq_DFB_Human1.00090502
85RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.99558029
86MYC_19030024_ChIP-ChIP_MESCs_Mouse0.98757764
87FOXA1_27270436_Chip-Seq_PROSTATE_Human0.95670063
88FOXA1_25329375_ChIP-Seq_VCAP_Human0.95670063
89REST_21632747_ChIP-Seq_MESCs_Mouse0.95416282
90BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.94920329
91ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.94131968
92GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93685149
93AR_20517297_ChIP-Seq_VCAP_Human0.93404397
94CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.91712170
95NANOG_19829295_ChIP-Seq_ESCs_Human0.90792641
96SOX2_19829295_ChIP-Seq_ESCs_Human0.90792641
97AUTS2_25519132_ChIP-Seq_293T-REX_Human0.90772549
98PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90623732
99YY1_22570637_ChIP-Seq_MALME-3M_Human0.90225161
100CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.89752067

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.01991986
2MP0002653_abnormal_ependyma_morphology2.71359817
3MP0002160_abnormal_reproductive_system2.38777089
4MP0005410_abnormal_fertilization2.30257181
5MP0002938_white_spotting2.24967237
6MP0003011_delayed_dark_adaptation2.21282853
7MP0008877_abnormal_DNA_methylation2.09267744
8MP0009379_abnormal_foot_pigmentation2.08754787
9MP0003136_yellow_coat_color2.08387934
10MP0008058_abnormal_DNA_repair2.04171820
11MP0003880_abnormal_central_pattern2.03465032
12MP0005551_abnormal_eye_electrophysiolog1.95531174
13MP0004133_heterotaxia1.93496861
14MP0005423_abnormal_somatic_nervous1.86741634
15MP0003693_abnormal_embryo_hatching1.86711200
16MP0008875_abnormal_xenobiotic_pharmacok1.77161422
17MP0000049_abnormal_middle_ear1.75851367
18MP0005389_reproductive_system_phenotype1.67902236
19MP0003890_abnormal_embryonic-extraembry1.66842813
20MP0001929_abnormal_gametogenesis1.66294949
21MP0000566_synostosis1.64466773
22MP0001529_abnormal_vocalization1.62805587
23MP0010030_abnormal_orbit_morphology1.60855677
24MP0003698_abnormal_male_reproductive1.60168282
25MP0002822_catalepsy1.53738459
26MP0002210_abnormal_sex_determination1.53521989
27MP0006072_abnormal_retinal_apoptosis1.50308401
28MP0001968_abnormal_touch/_nociception1.48855812
29MP0003718_maternal_effect1.48479314
30MP0008789_abnormal_olfactory_epithelium1.45143015
31MP0005084_abnormal_gallbladder_morpholo1.44457314
32MP0003195_calcinosis1.43515004
33MP0002234_abnormal_pharynx_morphology1.42659034
34MP0004142_abnormal_muscle_tone1.41939319
35MP0002102_abnormal_ear_morphology1.41797414
36MP0000631_abnormal_neuroendocrine_gland1.41465778
37MP0008995_early_reproductive_senescence1.40860259
38MP0001293_anophthalmia1.34533919
39MP0001986_abnormal_taste_sensitivity1.33701027
40MP0005253_abnormal_eye_physiology1.30015567
41MP0002736_abnormal_nociception_after1.25760190
42MP0010094_abnormal_chromosome_stability1.25397572
43MP0005646_abnormal_pituitary_gland1.24199258
44MP0002638_abnormal_pupillary_reflex1.20377857
45MP0001145_abnormal_male_reproductive1.19963387
46MP0001905_abnormal_dopamine_level1.19451456
47MP0000653_abnormal_sex_gland1.19045606
48MP0006276_abnormal_autonomic_nervous1.16966013
49MP0001485_abnormal_pinna_reflex1.16223478
50MP0005394_taste/olfaction_phenotype1.15964021
51MP0005499_abnormal_olfactory_system1.15964021
52MP0002735_abnormal_chemical_nociception1.15013867
53MP0002837_dystrophic_cardiac_calcinosis1.14676300
54MP0000372_irregular_coat_pigmentation1.14636570
55MP0003937_abnormal_limbs/digits/tail_de1.13247044
56MP0003878_abnormal_ear_physiology1.12045361
57MP0005377_hearing/vestibular/ear_phenot1.12045361
58MP0000569_abnormal_digit_pigmentation1.11131714
59MP0009046_muscle_twitch1.11096322
60MP0003806_abnormal_nucleotide_metabolis1.10914978
61MP0002282_abnormal_trachea_morphology1.10764550
62MP0001919_abnormal_reproductive_system1.08554664
63MP0002928_abnormal_bile_duct1.08507550
64MP0004885_abnormal_endolymph1.07490398
65MP0003119_abnormal_digestive_system1.07307521
66MP0005645_abnormal_hypothalamus_physiol1.07241014
67MP0002163_abnormal_gland_morphology1.06988108
68MP0009745_abnormal_behavioral_response1.06384609
69MP0002876_abnormal_thyroid_physiology1.04929333
70MP0002138_abnormal_hepatobiliary_system1.04295430
71MP0001486_abnormal_startle_reflex1.01901285
72MP0008872_abnormal_physiological_respon1.01753965
73MP0005083_abnormal_biliary_tract1.01203707
74MP0004742_abnormal_vestibular_system1.00517032
75MP0000026_abnormal_inner_ear1.00477863
76MP0002557_abnormal_social/conspecific_i1.00471189
77MP0005670_abnormal_white_adipose0.99094839
78MP0000778_abnormal_nervous_system0.98712106
79MP0002249_abnormal_larynx_morphology0.97642419
80MP0003111_abnormal_nucleus_morphology0.97184235
81MP0002752_abnormal_somatic_nervous0.95056396
82MP0003077_abnormal_cell_cycle0.94580724
83MP0002161_abnormal_fertility/fecundity0.94269742
84MP0002233_abnormal_nose_morphology0.93047928
85MP0002751_abnormal_autonomic_nervous0.92858214
86MP0002277_abnormal_respiratory_mucosa0.92271716
87MP0004957_abnormal_blastocyst_morpholog0.91902590
88MP0005195_abnormal_posterior_eye0.91826190
89MP0005174_abnormal_tail_pigmentation0.91528506
90MP0001502_abnormal_circadian_rhythm0.90615397
91MP0005379_endocrine/exocrine_gland_phen0.89648328
92MP0009250_abnormal_appendicular_skeleto0.89200165
93MP0003786_premature_aging0.88255648
94MP0003755_abnormal_palate_morphology0.86318326
95MP0004043_abnormal_pH_regulation0.86154149
96MP0002272_abnormal_nervous_system0.85647637
97MP0000955_abnormal_spinal_cord0.81947279
98MP0005391_vision/eye_phenotype0.81125985
99MP0001286_abnormal_eye_development0.80810600
100MP0003315_abnormal_perineum_morphology0.80719941

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)4.11496869
2Absent/shortened dynein arms (HP:0200106)4.11496869
3Abnormal respiratory motile cilium morphology (HP:0005938)3.96390616
4Abnormal respiratory epithelium morphology (HP:0012253)3.96390616
5Molar tooth sign on MRI (HP:0002419)3.92157999
6Abnormality of midbrain morphology (HP:0002418)3.92157999
7Pancreatic fibrosis (HP:0100732)3.80790825
8Pancreatic cysts (HP:0001737)3.68850722
9True hermaphroditism (HP:0010459)3.65609765
10Abnormal ciliary motility (HP:0012262)3.60886326
11Abnormal respiratory motile cilium physiology (HP:0012261)3.51313198
12Acute necrotizing encephalopathy (HP:0006965)3.40295465
13Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.37646519
14Nephronophthisis (HP:0000090)3.30383770
15Chronic hepatic failure (HP:0100626)3.10732929
16Mitochondrial inheritance (HP:0001427)3.10212157
17Abnormal mitochondria in muscle tissue (HP:0008316)2.99067121
18Abnormal number of erythroid precursors (HP:0012131)2.98410219
19Acute encephalopathy (HP:0006846)2.90196203
20Increased CSF lactate (HP:0002490)2.85474986
21Progressive macrocephaly (HP:0004481)2.81109251
22Abnormality of cells of the erythroid lineage (HP:0012130)2.77939518
23Abnormality of the renal medulla (HP:0100957)2.77273639
24Pendular nystagmus (HP:0012043)2.72993377
25Rhinitis (HP:0012384)2.59805458
26Hepatocellular necrosis (HP:0001404)2.58755127
27Cystic liver disease (HP:0006706)2.58704010
28Increased hepatocellular lipid droplets (HP:0006565)2.58640490
29Lipid accumulation in hepatocytes (HP:0006561)2.51069384
30Sclerocornea (HP:0000647)2.48601920
31Medial flaring of the eyebrow (HP:0010747)2.43975051
32Tubulointerstitial nephritis (HP:0001970)2.43548080
33Renal Fanconi syndrome (HP:0001994)2.41205354
34Aplasia/Hypoplasia of the uvula (HP:0010293)2.40507740
35Abnormality of the renal cortex (HP:0011035)2.38544143
36Abnormal rod and cone electroretinograms (HP:0008323)2.37270435
37Attenuation of retinal blood vessels (HP:0007843)2.35827278
38Anencephaly (HP:0002323)2.33026150
39Hepatic necrosis (HP:0002605)2.31048358
40Tubular atrophy (HP:0000092)2.29573272
41Congenital stationary night blindness (HP:0007642)2.29249970
42Type II lissencephaly (HP:0007260)2.28870053
43Polydipsia (HP:0001959)2.23513962
44Abnormal drinking behavior (HP:0030082)2.23513962
45Absent thumb (HP:0009777)2.22889814
46Bony spicule pigmentary retinopathy (HP:0007737)2.21861185
47Congenital, generalized hypertrichosis (HP:0004540)2.20852097
48Congenital hepatic fibrosis (HP:0002612)2.18765979
49Male pseudohermaphroditism (HP:0000037)2.16603973
50Occipital encephalocele (HP:0002085)2.15946302
51Meckel diverticulum (HP:0002245)2.14635631
52Retinal dysplasia (HP:0007973)2.10356802
53Abnormality of the ileum (HP:0001549)2.10350568
543-Methylglutaconic aciduria (HP:0003535)2.07078615
55Reticulocytopenia (HP:0001896)2.05445015
56Increased serum lactate (HP:0002151)2.04785291
57Concave nail (HP:0001598)2.01862050
58Rib fusion (HP:0000902)2.01163406
59Aplasia/Hypoplasia of the tongue (HP:0010295)1.98785159
60Optic disc pallor (HP:0000543)1.98599856
61Infertility (HP:0000789)1.97624709
62Hypoplasia of the pons (HP:0012110)1.95697942
63Chromsome breakage (HP:0040012)1.95156785
64Patellar aplasia (HP:0006443)1.95007289
65Macrocytic anemia (HP:0001972)1.92525853
66Cerebral edema (HP:0002181)1.92152461
67Chromosomal breakage induced by crosslinking agents (HP:0003221)1.91536984
68Absent rod-and cone-mediated responses on ERG (HP:0007688)1.90692464
69Postaxial foot polydactyly (HP:0001830)1.90412229
70Aplasia/Hypoplasia of the patella (HP:0006498)1.90049065
71Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.89243455
72Abnormality of alanine metabolism (HP:0010916)1.89243455
73Hyperalaninemia (HP:0003348)1.89243455
74Septo-optic dysplasia (HP:0100842)1.88902145
75Abnormality of the pons (HP:0007361)1.88299460
76Polyuria (HP:0000103)1.87139160
77Abnormality of the carotid arteries (HP:0005344)1.86678503
78Bronchiectasis (HP:0002110)1.84303426
79Anophthalmia (HP:0000528)1.83967039
80Preaxial hand polydactyly (HP:0001177)1.83205632
81Optic nerve hypoplasia (HP:0000609)1.82971879
82Cerebellar dysplasia (HP:0007033)1.81109522
83Decreased central vision (HP:0007663)1.80086366
84Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.77114060
85Abnormality of the preputium (HP:0100587)1.75478610
86Hypoplasia of the uterus (HP:0000013)1.75364781
87Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.74578879
88Sloping forehead (HP:0000340)1.73639226
89Supernumerary spleens (HP:0009799)1.73337642
90Bilateral microphthalmos (HP:0007633)1.72690376
91Birth length less than 3rd percentile (HP:0003561)1.72477296
92Tubulointerstitial abnormality (HP:0001969)1.72350419
93Postaxial hand polydactyly (HP:0001162)1.72254438
94Small hand (HP:0200055)1.71900475
95Triphalangeal thumb (HP:0001199)1.71764523
96Aplasia/Hypoplasia of the spleen (HP:0010451)1.71186969
97Abolished electroretinogram (ERG) (HP:0000550)1.71170067
98Lactic acidosis (HP:0003128)1.70934130
99Gait imbalance (HP:0002141)1.70563784
100Chronic bronchitis (HP:0004469)1.70543039

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK4.37416485
2TLK14.22538819
3BMPR1B3.25212711
4PNCK3.19004981
5PLK43.05717503
6WNK42.71514642
7MAP4K22.52978262
8STK162.49243828
9MAPK152.47767100
10INSRR2.22453803
11ADRBK22.18044687
12VRK12.08701006
13VRK21.93217987
14WNK31.90896057
15FRK1.90135787
16GRK11.81464923
17NUAK11.78058150
18DYRK21.74881238
19NME11.63031636
20PINK11.57001784
21NEK21.52187886
22BUB11.51235190
23CCNB11.49214985
24STK391.46606024
25CASK1.30615889
26PLK21.24483846
27MUSK1.23535898
28PLK11.22724011
29WEE11.19540705
30MAPKAPK31.12328889
31CDC71.06255394
32MAPK131.01138251
33RPS6KA51.00716479
34OXSR10.99373795
35ATR0.98804250
36CHEK20.97896329
37BCKDK0.96369201
38PLK30.93086333
39AURKA0.91992490
40BRSK20.91066978
41TRIM280.90747032
42MKNK20.88405472
43SRPK10.86675723
44TGFBR10.86178939
45TSSK60.84527860
46TAOK30.84498114
47PRKCG0.84387075
48TIE10.82642977
49PAK30.80515264
50CAMK1G0.79235789
51PDK20.79188188
52ADRBK10.78159619
53MAP2K70.78070610
54SIK20.74489878
55AURKB0.70666293
56MAP3K40.70599649
57CSNK1G10.69644437
58PASK0.68471527
59MAPKAPK50.66930136
60TTK0.65436070
61ACVR1B0.64975809
62PHKG10.64219647
63PHKG20.64219647
64PIM20.62864073
65BRSK10.62224288
66EPHA40.61905505
67PRKCI0.60636392
68TAF10.59856709
69CSNK1G30.59725002
70PTK2B0.58301218
71CDK80.57701332
72MKNK10.57429727
73CSNK1G20.56514608
74CDK70.56049626
75PKN10.51751840
76DYRK30.51632863
77MAP3K120.51180928
78ABL20.50361893
79NTRK20.49968174
80DAPK20.49917304
81CSNK1A10.49752399
82ATM0.49514143
83EPHB20.48349960
84FGFR20.47897499
85CSNK2A10.46193150
86CSNK2A20.45642754
87PBK0.44752361
88PRKCE0.43990445
89TNIK0.43102234
90PRKACA0.42109855
91CSNK1E0.40653895
92CDK30.39397776
93CAMK10.39211407
94CHEK10.38544141
95PRKCQ0.37924885
96CSNK1A1L0.36499512
97CAMK2A0.33271611
98MARK10.33160876
99CHUK0.32469059
100PIK3CA0.31896554

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.01320896
2Oxidative phosphorylation_Homo sapiens_hsa001903.75718947
3Parkinsons disease_Homo sapiens_hsa050123.08744587
4RNA polymerase_Homo sapiens_hsa030202.61735159
5Homologous recombination_Homo sapiens_hsa034402.56055335
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.51921844
7Huntingtons disease_Homo sapiens_hsa050162.50827290
8Fanconi anemia pathway_Homo sapiens_hsa034602.31058874
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.16444829
10Sulfur relay system_Homo sapiens_hsa041222.10124925
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.02083373
12Phototransduction_Homo sapiens_hsa047441.99395795
13One carbon pool by folate_Homo sapiens_hsa006701.96192383
14Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.92069339
15Alzheimers disease_Homo sapiens_hsa050101.90365853
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.88866209
17Cardiac muscle contraction_Homo sapiens_hsa042601.86325045
18Basal transcription factors_Homo sapiens_hsa030221.85787578
19Linoleic acid metabolism_Homo sapiens_hsa005911.83332352
20Proteasome_Homo sapiens_hsa030501.81242066
21Caffeine metabolism_Homo sapiens_hsa002321.81045334
22Protein export_Homo sapiens_hsa030601.76256483
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.74387130
24Nitrogen metabolism_Homo sapiens_hsa009101.71926610
25DNA replication_Homo sapiens_hsa030301.70345442
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.59305341
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.56673972
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.52329804
29Mismatch repair_Homo sapiens_hsa034301.48945079
30Selenocompound metabolism_Homo sapiens_hsa004501.44581118
31Nucleotide excision repair_Homo sapiens_hsa034201.38243689
32Pyrimidine metabolism_Homo sapiens_hsa002401.37095737
33RNA degradation_Homo sapiens_hsa030181.37086327
34Folate biosynthesis_Homo sapiens_hsa007901.36552721
35Base excision repair_Homo sapiens_hsa034101.35883924
36Spliceosome_Homo sapiens_hsa030401.34099247
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.30064691
38RNA transport_Homo sapiens_hsa030131.27066870
39Nicotine addiction_Homo sapiens_hsa050331.23982447
40Purine metabolism_Homo sapiens_hsa002301.10818456
41Tryptophan metabolism_Homo sapiens_hsa003801.06662262
42Ether lipid metabolism_Homo sapiens_hsa005651.05606271
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.99869444
44Systemic lupus erythematosus_Homo sapiens_hsa053220.98740224
45Butanoate metabolism_Homo sapiens_hsa006500.96561663
46Non-homologous end-joining_Homo sapiens_hsa034500.91831890
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90924435
48Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.90626266
49Taste transduction_Homo sapiens_hsa047420.84176827
50Olfactory transduction_Homo sapiens_hsa047400.82799346
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.82182280
52Chemical carcinogenesis_Homo sapiens_hsa052040.80887868
53Vitamin digestion and absorption_Homo sapiens_hsa049770.80362122
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79836827
55Metabolic pathways_Homo sapiens_hsa011000.78510632
56Peroxisome_Homo sapiens_hsa041460.77661405
57Alcoholism_Homo sapiens_hsa050340.77476301
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.76407222
59Retinol metabolism_Homo sapiens_hsa008300.72298952
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.71582866
61Pyruvate metabolism_Homo sapiens_hsa006200.68490909
62Regulation of autophagy_Homo sapiens_hsa041400.67505718
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.65029806
64Cell cycle_Homo sapiens_hsa041100.64739301
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.63065642
66Hedgehog signaling pathway_Homo sapiens_hsa043400.62660188
67Arachidonic acid metabolism_Homo sapiens_hsa005900.62171336
68Propanoate metabolism_Homo sapiens_hsa006400.62060503
69Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.60374673
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58854447
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57710496
72Basal cell carcinoma_Homo sapiens_hsa052170.56934795
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.56754927
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56554534
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50772161
76Fatty acid degradation_Homo sapiens_hsa000710.47842898
77Steroid biosynthesis_Homo sapiens_hsa001000.44666402
78Collecting duct acid secretion_Homo sapiens_hsa049660.43225391
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41745902
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39993577
81Fat digestion and absorption_Homo sapiens_hsa049750.37108349
82beta-Alanine metabolism_Homo sapiens_hsa004100.36960315
83Fatty acid biosynthesis_Homo sapiens_hsa000610.36699611
84Morphine addiction_Homo sapiens_hsa050320.35583001
85Dorso-ventral axis formation_Homo sapiens_hsa043200.34990111
86p53 signaling pathway_Homo sapiens_hsa041150.34146792
87Glycerolipid metabolism_Homo sapiens_hsa005610.33669450
88ABC transporters_Homo sapiens_hsa020100.33631863
89TGF-beta signaling pathway_Homo sapiens_hsa043500.33292067
90Serotonergic synapse_Homo sapiens_hsa047260.33095682
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32792976
92Histidine metabolism_Homo sapiens_hsa003400.32518509
93Oocyte meiosis_Homo sapiens_hsa041140.32099692
94Lysine degradation_Homo sapiens_hsa003100.32049215
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.31771269
96Arginine and proline metabolism_Homo sapiens_hsa003300.31692520
97Cocaine addiction_Homo sapiens_hsa050300.29470796
98Circadian rhythm_Homo sapiens_hsa047100.29152485
99Tyrosine metabolism_Homo sapiens_hsa003500.27711933
100Glutathione metabolism_Homo sapiens_hsa004800.25906441

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