C19ORF18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of hexokinase activity (GO:1903299)4.86277247
2regulation of glucokinase activity (GO:0033131)4.86277247
3regulation of protein glycosylation (GO:0060049)4.61797806
4regulation of type B pancreatic cell apoptotic process (GO:2000674)4.60273289
5positive regulation of respiratory burst (GO:0060267)4.56444936
6cellular ketone body metabolic process (GO:0046950)4.33927287
7positive regulation of glycolytic process (GO:0045821)4.24443227
8auditory receptor cell differentiation (GO:0042491)4.06059065
9signal peptide processing (GO:0006465)3.87414354
10negative regulation of cytosolic calcium ion concentration (GO:0051481)3.85021143
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.78836289
12ketone body metabolic process (GO:1902224)3.74869385
13seminiferous tubule development (GO:0072520)3.67498854
14axoneme assembly (GO:0035082)3.65810560
15dendritic spine morphogenesis (GO:0060997)3.59473385
16presynaptic membrane organization (GO:0097090)3.58687831
17regulation of respiratory burst (GO:0060263)3.54964322
18piRNA metabolic process (GO:0034587)3.48107606
19presynaptic membrane assembly (GO:0097105)3.41368562
20negative regulation of protein oligomerization (GO:0032460)3.39204284
21protein import into peroxisome matrix (GO:0016558)3.20493084
22L-fucose catabolic process (GO:0042355)3.18796001
23fucose catabolic process (GO:0019317)3.18796001
24L-fucose metabolic process (GO:0042354)3.18796001
25positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.16925616
26negative regulation of acute inflammatory response (GO:0002674)3.16546616
27mitochondrial respiratory chain complex I assembly (GO:0032981)3.16268661
28NADH dehydrogenase complex assembly (GO:0010257)3.16268661
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.16268661
30preassembly of GPI anchor in ER membrane (GO:0016254)3.14060933
31lactate metabolic process (GO:0006089)3.07969565
32cellular biogenic amine catabolic process (GO:0042402)3.05004207
33amine catabolic process (GO:0009310)3.05004207
34hair cell differentiation (GO:0035315)3.04554533
35inositol phosphate catabolic process (GO:0071545)2.99391523
36DNA methylation involved in gamete generation (GO:0043046)2.97605286
37protein complex biogenesis (GO:0070271)2.93816141
38membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.92963331
39vascular smooth muscle contraction (GO:0014829)2.92203410
40regulation of feeding behavior (GO:0060259)2.90894739
41macroautophagy (GO:0016236)2.89931225
42detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.88975988
43branched-chain amino acid catabolic process (GO:0009083)2.88422682
44fatty acid homeostasis (GO:0055089)2.88420630
45central nervous system myelination (GO:0022010)2.85591155
46axon ensheathment in central nervous system (GO:0032291)2.85591155
47regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.83518660
48xenobiotic catabolic process (GO:0042178)2.82092637
49RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.77701351
50tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.77701351
51positive regulation of protein autophosphorylation (GO:0031954)2.74756245
52epithelial cilium movement (GO:0003351)2.72779755
53endocrine pancreas development (GO:0031018)2.72604830
54GPI anchor biosynthetic process (GO:0006506)2.72010255
55chemosensory behavior (GO:0007635)2.71358497
56negative regulation of JUN kinase activity (GO:0043508)2.70491358
57negative regulation of appetite (GO:0032099)2.68331484
58negative regulation of response to food (GO:0032096)2.68331484
59ubiquinone biosynthetic process (GO:0006744)2.66432388
60regulation of transmission of nerve impulse (GO:0051969)2.66156341
61lateral ventricle development (GO:0021670)2.65974162
62nonmotile primary cilium assembly (GO:0035058)2.64835701
63nitric oxide mediated signal transduction (GO:0007263)2.63669453
64hyperosmotic salinity response (GO:0042538)2.63569560
65aggressive behavior (GO:0002118)2.62126238
66GPI anchor metabolic process (GO:0006505)2.59203614
67cilium movement (GO:0003341)2.58446444
68negative regulation of telomere maintenance (GO:0032205)2.56885698
69cellular response to leptin stimulus (GO:0044320)2.56725282
70dentate gyrus development (GO:0021542)2.54182658
71establishment of protein localization to Golgi (GO:0072600)2.53515299
72erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.53514191
73L-phenylalanine catabolic process (GO:0006559)2.53514191
74adaptation of signaling pathway (GO:0023058)2.51781535
75protein targeting to Golgi (GO:0000042)2.51740275
76C-terminal protein lipidation (GO:0006501)2.50781531
77retrograde transport, vesicle recycling within Golgi (GO:0000301)2.49044020
78regulation of cilium movement (GO:0003352)2.47850430
79photoreceptor cell maintenance (GO:0045494)2.47201313
80axonemal dynein complex assembly (GO:0070286)2.45782503
81ubiquinone metabolic process (GO:0006743)2.45636940
82negative regulation of mast cell activation (GO:0033004)2.45247099
83negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.45191429
84regulation of timing of cell differentiation (GO:0048505)2.43192218
85calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.41588508
86positive regulation of cell fate commitment (GO:0010455)2.41417483
87positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.40801979
88positive regulation of glycogen biosynthetic process (GO:0045725)2.40724191
89regulation of glycolytic process (GO:0006110)2.40619353
90kidney morphogenesis (GO:0060993)2.40091231
91negative regulation of neurological system process (GO:0031645)2.38584545
92mitochondrial respiratory chain complex assembly (GO:0033108)2.38241174
93aromatic amino acid family catabolic process (GO:0009074)2.36275789
94regulation of microtubule-based movement (GO:0060632)2.35531752
95cilium morphogenesis (GO:0060271)2.34931870
96regulation of non-canonical Wnt signaling pathway (GO:2000050)2.33937238
97positive regulation of peptide secretion (GO:0002793)2.33132330
98protein localization to Golgi apparatus (GO:0034067)2.32737041
99positive regulation of peptide hormone secretion (GO:0090277)2.32600498
100negative regulation of gluconeogenesis (GO:0045721)2.31886818

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.30831834
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.79231499
3ZNF274_21170338_ChIP-Seq_K562_Hela2.96108455
4SALL1_21062744_ChIP-ChIP_HESCs_Human2.86392287
5EZH2_22144423_ChIP-Seq_EOC_Human2.67412685
6VDR_22108803_ChIP-Seq_LS180_Human2.53590231
7IGF1R_20145208_ChIP-Seq_DFB_Human2.44779242
8GBX2_23144817_ChIP-Seq_PC3_Human2.32753770
9NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.19415727
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.16035753
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.02575742
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.01147927
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.98821204
14EST1_17652178_ChIP-ChIP_JURKAT_Human1.93413687
15POU3F2_20337985_ChIP-ChIP_501MEL_Human1.88503869
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83416263
17TAF15_26573619_Chip-Seq_HEK293_Human1.79612646
18ER_23166858_ChIP-Seq_MCF-7_Human1.75632960
19EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.73629343
20FLI1_27457419_Chip-Seq_LIVER_Mouse1.72754101
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.69819959
22P300_19829295_ChIP-Seq_ESCs_Human1.68459418
23TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68294491
24POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.68294491
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.67958891
26IRF1_19129219_ChIP-ChIP_H3396_Human1.64252059
27CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.63409309
28SMAD4_21799915_ChIP-Seq_A2780_Human1.58624597
29BCAT_22108803_ChIP-Seq_LS180_Human1.55781306
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.55775497
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48798319
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.47706278
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.45411402
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40317181
35ETV2_25802403_ChIP-Seq_MESCs_Mouse1.35791867
36CBP_20019798_ChIP-Seq_JUKART_Human1.34810527
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34810527
38MYC_18940864_ChIP-ChIP_HL60_Human1.33561964
39STAT3_23295773_ChIP-Seq_U87_Human1.32149557
40* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.30832449
41SOX2_19829295_ChIP-Seq_ESCs_Human1.30376396
42NANOG_19829295_ChIP-Seq_ESCs_Human1.30376396
43TP53_22573176_ChIP-Seq_HFKS_Human1.30075088
44FUS_26573619_Chip-Seq_HEK293_Human1.28205300
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.26767165
46TCF4_22108803_ChIP-Seq_LS180_Human1.21956101
47SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21351174
48RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.20985711
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.19488170
50EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.19105607
51UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17211601
52NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15736206
53ETS1_20019798_ChIP-Seq_JURKAT_Human1.15703180
54AR_20517297_ChIP-Seq_VCAP_Human1.15574527
55RNF2_27304074_Chip-Seq_NSC_Mouse1.14407135
56CDX2_22108803_ChIP-Seq_LS180_Human1.13943169
57MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13454470
58ELK1_19687146_ChIP-ChIP_HELA_Human1.10818392
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09793212
60TCF4_23295773_ChIP-Seq_U87_Human1.09669709
61RXR_22108803_ChIP-Seq_LS180_Human1.09651753
62FOXA1_25329375_ChIP-Seq_VCAP_Human1.09624039
63FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09624039
64AR_25329375_ChIP-Seq_VCAP_Human1.07162025
65FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05761910
66PRDM14_20953172_ChIP-Seq_ESCs_Human1.05356363
67* CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.05237083
68MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05018428
69REST_21632747_ChIP-Seq_MESCs_Mouse1.01889246
70NANOG_18555785_Chip-Seq_ESCs_Mouse1.00918320
71EWS_26573619_Chip-Seq_HEK293_Human0.98935332
72EZH2_27294783_Chip-Seq_NPCs_Mouse0.97983831
73NFE2_27457419_Chip-Seq_LIVER_Mouse0.97409486
74CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.97323524
75RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96530632
76EP300_21415370_ChIP-Seq_HL-1_Mouse0.96328354
77BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96305368
78HTT_18923047_ChIP-ChIP_STHdh_Human0.96052714
79PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94921458
80SUZ12_27294783_Chip-Seq_NPCs_Mouse0.93562245
81AUTS2_25519132_ChIP-Seq_293T-REX_Human0.92863868
82TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92773491
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92097273
84CDX2_19796622_ChIP-Seq_MESCs_Mouse0.91166321
85ETV1_20927104_ChIP-Seq_GIST48_Human0.90433228
86FLI1_21867929_ChIP-Seq_TH2_Mouse0.90384483
87TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90345660
88EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.89868483
89RUNX2_22187159_ChIP-Seq_PCA_Human0.89504584
90* TAF2_19829295_ChIP-Seq_ESCs_Human0.89066577
91SMAD4_21741376_ChIP-Seq_EPCs_Human0.88715290
92PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.88251588
93GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.87668741
94MYC_19829295_ChIP-Seq_ESCs_Human0.87483790
95ARNT_22903824_ChIP-Seq_MCF-7_Human0.87261898
96TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.86711068
97MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86342926
98VDR_23849224_ChIP-Seq_CD4+_Human0.85908815
99TBL1_22424771_ChIP-Seq_293T_Human0.85083913
100P53_22387025_ChIP-Seq_ESCs_Mouse0.84771144

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.18238143
2MP0003787_abnormal_imprinting3.50814315
3MP0002653_abnormal_ependyma_morphology3.19025737
4MP0003880_abnormal_central_pattern3.09414895
5MP0008877_abnormal_DNA_methylation2.84857954
6MP0009379_abnormal_foot_pigmentation2.69035672
7MP0003011_delayed_dark_adaptation2.65082216
8MP0001984_abnormal_olfaction2.49273710
9MP0001986_abnormal_taste_sensitivity2.44000408
10MP0005379_endocrine/exocrine_gland_phen2.41096090
11MP0005423_abnormal_somatic_nervous2.32665924
12MP0002163_abnormal_gland_morphology2.20750861
13MP0006292_abnormal_olfactory_placode2.19544084
14MP0000427_abnormal_hair_cycle2.14248463
15MP0001485_abnormal_pinna_reflex2.12305251
16MP0005551_abnormal_eye_electrophysiolog2.11625445
17MP0009780_abnormal_chondrocyte_physiolo2.00471120
18MP0001486_abnormal_startle_reflex1.99115941
19MP0003283_abnormal_digestive_organ1.97966328
20MP0002736_abnormal_nociception_after1.96962812
21MP0001529_abnormal_vocalization1.86047742
22MP0001968_abnormal_touch/_nociception1.83424944
23MP0006276_abnormal_autonomic_nervous1.71564076
24MP0008789_abnormal_olfactory_epithelium1.66728981
25MP0000462_abnormal_digestive_system1.62042642
26MP0002876_abnormal_thyroid_physiology1.56193560
27MP0002234_abnormal_pharynx_morphology1.54580826
28MP0003122_maternal_imprinting1.52159181
29MP0006072_abnormal_retinal_apoptosis1.48862243
30MP0003195_calcinosis1.44826759
31MP0005377_hearing/vestibular/ear_phenot1.41460596
32MP0003878_abnormal_ear_physiology1.41460596
33MP0005253_abnormal_eye_physiology1.40241269
34MP0004043_abnormal_pH_regulation1.35421075
35MP0004084_abnormal_cardiac_muscle1.34185444
36MP0001501_abnormal_sleep_pattern1.34097558
37MP0003121_genomic_imprinting1.33964072
38MP0004270_analgesia1.31888947
39MP0002928_abnormal_bile_duct1.31339043
40MP0009046_muscle_twitch1.28315763
41MP0002138_abnormal_hepatobiliary_system1.28231345
42MP0002938_white_spotting1.26263237
43MP0008875_abnormal_xenobiotic_pharmacok1.23857602
44MP0001502_abnormal_circadian_rhythm1.23359431
45MP0002734_abnormal_mechanical_nocicepti1.22902264
46MP0002572_abnormal_emotion/affect_behav1.21392479
47MP0009745_abnormal_behavioral_response1.21154498
48MP0008058_abnormal_DNA_repair1.21021354
49MP0005386_behavior/neurological_phenoty1.20594725
50MP0004924_abnormal_behavior1.20594725
51MP0003786_premature_aging1.20073349
52MP0001905_abnormal_dopamine_level1.19345916
53MP0004145_abnormal_muscle_electrophysio1.18022443
54MP0005220_abnormal_exocrine_pancreas1.17822276
55MP0004885_abnormal_endolymph1.16130016
56MP0010386_abnormal_urinary_bladder1.15251315
57MP0004133_heterotaxia1.13253008
58MP0000613_abnormal_salivary_gland1.11283024
59MP0000013_abnormal_adipose_tissue1.10459784
60MP0005332_abnormal_amino_acid1.10441604
61MP0003186_abnormal_redox_activity1.10142622
62MP0005499_abnormal_olfactory_system1.08501469
63MP0005394_taste/olfaction_phenotype1.08501469
64MP0008872_abnormal_physiological_respon1.07740617
65MP0008775_abnormal_heart_ventricle1.06911215
66MP0002272_abnormal_nervous_system1.06772441
67MP0002693_abnormal_pancreas_physiology1.04375115
68MP0002822_catalepsy1.01437220
69MP0004142_abnormal_muscle_tone0.97440911
70MP0000516_abnormal_urinary_system0.93676690
71MP0005367_renal/urinary_system_phenotyp0.93676690
72MP0005084_abnormal_gallbladder_morpholo0.93117235
73MP0010234_abnormal_vibrissa_follicle0.91576537
74MP0001970_abnormal_pain_threshold0.91293834
75MP0002067_abnormal_sensory_capabilities0.89603310
76MP0001963_abnormal_hearing_physiology0.88973896
77MP0003950_abnormal_plasma_membrane0.88931286
78MP0002909_abnormal_adrenal_gland0.87792676
79MP0000538_abnormal_urinary_bladder0.86948508
80MP0001944_abnormal_pancreas_morphology0.85829501
81MP0002233_abnormal_nose_morphology0.85475309
82MP0002102_abnormal_ear_morphology0.84564667
83MP0002557_abnormal_social/conspecific_i0.84414151
84MP0000749_muscle_degeneration0.84339594
85MP0002095_abnormal_skin_pigmentation0.84179784
86MP0005670_abnormal_white_adipose0.83975987
87MP0005645_abnormal_hypothalamus_physiol0.83925541
88MP0002160_abnormal_reproductive_system0.82132113
89MP0005389_reproductive_system_phenotype0.81118857
90MP0004742_abnormal_vestibular_system0.79577930
91MP0003718_maternal_effect0.79552458
92MP0001849_ear_inflammation0.79414450
93MP0002229_neurodegeneration0.77694065
94MP0004019_abnormal_vitamin_homeostasis0.75857297
95MP0003123_paternal_imprinting0.75654239
96MP0002282_abnormal_trachea_morphology0.75499751
97MP0000631_abnormal_neuroendocrine_gland0.73345786
98MP0008961_abnormal_basal_metabolism0.73034888
99MP0003698_abnormal_male_reproductive0.72984642
100MP0002090_abnormal_vision0.72261593

Predicted human phenotypes

RankGene SetZ-score
1Type II lissencephaly (HP:0007260)4.73349523
2Ketoacidosis (HP:0001993)4.41906383
3Renal cortical cysts (HP:0000803)4.19635321
4Calf muscle hypertrophy (HP:0008981)4.11561879
5Retinal dysplasia (HP:0007973)4.08797051
6Abnormality of midbrain morphology (HP:0002418)4.06297264
7Molar tooth sign on MRI (HP:0002419)4.06297264
8Pancreatic fibrosis (HP:0100732)3.83285228
9Pancreatic cysts (HP:0001737)3.75179181
10Nephronophthisis (HP:0000090)3.69833266
11Muscle hypertrophy of the lower extremities (HP:0008968)3.64820835
12Hyperinsulinemic hypoglycemia (HP:0000825)3.62691608
13Ketosis (HP:0001946)3.48602889
14True hermaphroditism (HP:0010459)3.47641289
15Medial flaring of the eyebrow (HP:0010747)3.47465639
16Hypoglycemic seizures (HP:0002173)3.38402792
17Abnormality of the renal cortex (HP:0011035)3.34425989
18Hypoglycemic coma (HP:0001325)3.18464051
19Abnormality of the renal medulla (HP:0100957)3.10095821
20Abnormality of the calf musculature (HP:0001430)3.09781355
21Mitochondrial inheritance (HP:0001427)3.01303315
22Acute necrotizing encephalopathy (HP:0006965)2.94856279
23Progressive macrocephaly (HP:0004481)2.93963219
24Gait imbalance (HP:0002141)2.92217684
25Hepatic necrosis (HP:0002605)2.90738542
26Congenital primary aphakia (HP:0007707)2.90417498
27Entropion (HP:0000621)2.86583778
28Prominent metopic ridge (HP:0005487)2.85317503
29Hyperventilation (HP:0002883)2.76198494
30Cystic liver disease (HP:0006706)2.70852936
31Disproportionate short-trunk short stature (HP:0003521)2.70732686
32Increased hepatocellular lipid droplets (HP:0006565)2.68613076
33Nephrogenic diabetes insipidus (HP:0009806)2.65789459
34Abnormal mitochondria in muscle tissue (HP:0008316)2.63864100
35Increased intramyocellular lipid droplets (HP:0012240)2.63844531
36Abnormality of the metopic suture (HP:0005556)2.58112780
37Sclerocornea (HP:0000647)2.57360274
38Acute encephalopathy (HP:0006846)2.55298103
39Hepatocellular necrosis (HP:0001404)2.49646356
40Abolished electroretinogram (ERG) (HP:0000550)2.48252943
41Median cleft lip (HP:0000161)2.42613680
42Lipid accumulation in hepatocytes (HP:0006561)2.41225787
43Broad-based gait (HP:0002136)2.37013249
44Hypothermia (HP:0002045)2.36126761
45Increased CSF lactate (HP:0002490)2.36062233
46Abnormality of DNA repair (HP:0003254)2.34619722
47Abnormality of the pancreatic islet cells (HP:0006476)2.33598676
48Abnormality of endocrine pancreas physiology (HP:0012093)2.33598676
49Congenital hepatic fibrosis (HP:0002612)2.29300729
50Aplasia/Hypoplasia of the tongue (HP:0010295)2.27385968
51Methylmalonic acidemia (HP:0002912)2.26527902
52Increased muscle lipid content (HP:0009058)2.26224416
53Renal Fanconi syndrome (HP:0001994)2.20926783
54Hip dysplasia (HP:0001385)2.19405278
55Thyroiditis (HP:0100646)2.17748771
56Gowers sign (HP:0003391)2.17152347
57Type 2 muscle fiber atrophy (HP:0003554)2.16153611
58Abnormality of urine glucose concentration (HP:0011016)2.15762129
59Glycosuria (HP:0003076)2.15762129
60Hemiparesis (HP:0001269)2.14933867
61Genital tract atresia (HP:0001827)2.11612571
62Neoplasm of the adrenal cortex (HP:0100641)2.11504247
63Large for gestational age (HP:0001520)2.10988954
64Hypomagnesemia (HP:0002917)2.10426455
65Vaginal atresia (HP:0000148)2.10371693
66Hyperglycemia (HP:0003074)2.09659570
67Nonprogressive disorder (HP:0003680)2.07078369
68Hip contracture (HP:0003273)2.06456552
69Flat capital femoral epiphysis (HP:0003370)2.04717403
70Methylmalonic aciduria (HP:0012120)2.00608038
71Prolonged neonatal jaundice (HP:0006579)2.00172002
72Increased corneal curvature (HP:0100692)1.97712563
73Keratoconus (HP:0000563)1.97712563
74Postaxial hand polydactyly (HP:0001162)1.95336131
75Anencephaly (HP:0002323)1.94760510
76Left ventricular hypertrophy (HP:0001712)1.91793186
77Bile duct proliferation (HP:0001408)1.91104216
78Abnormal biliary tract physiology (HP:0012439)1.91104216
79Poikiloderma (HP:0001029)1.91022899
80Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.90320296
81Stridor (HP:0010307)1.87474635
82Asplenia (HP:0001746)1.87169655
83Long foot (HP:0001833)1.86133517
84Colon cancer (HP:0003003)1.85995656
85Delayed CNS myelination (HP:0002188)1.84850310
86Postaxial foot polydactyly (HP:0001830)1.83917902
87Fetal akinesia sequence (HP:0001989)1.83326930
88Male pseudohermaphroditism (HP:0000037)1.81134947
89Aplasia/Hypoplasia of the spleen (HP:0010451)1.80623021
90Occipital encephalocele (HP:0002085)1.80342491
91Abnormal drinking behavior (HP:0030082)1.77729109
92Polydipsia (HP:0001959)1.77729109
93Agitation (HP:0000713)1.74708408
94Respiratory failure (HP:0002878)1.74086775
95Metaphyseal dysplasia (HP:0100255)1.73740963
96Hyperglycinuria (HP:0003108)1.73433119
97Enlarged kidneys (HP:0000105)1.73300719
98Supernumerary spleens (HP:0009799)1.72563752
99Hypsarrhythmia (HP:0002521)1.72458501
100Tachypnea (HP:0002789)1.71963321

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.77085929
2MUSK3.38589522
3CDK192.85367412
4BMPR1B2.84383526
5FGFR22.71360103
6PAK32.53700558
7STK392.47286692
8LMTK22.43577897
9PINK12.05955412
10CASK2.02777361
11STK162.00415589
12WNK41.74643721
13STK38L1.61288044
14PHKG21.53382352
15PHKG11.53382352
16WNK31.47001902
17PDK21.45663936
18STK31.37914923
19TIE11.33301055
20LIMK11.33235872
21GRK11.32489291
22OXSR11.29180578
23INSRR1.26125002
24NTRK31.24869189
25MAP3K71.19252653
26STK241.17385061
27MAP3K41.14625290
28TRIM281.14123868
29MARK11.13674161
30VRK21.13012632
31MET1.12324338
32MAP2K71.12115957
33NUAK11.09202231
34FER1.09109170
35ACVR1B1.07674260
36PRKCE1.05114510
37ADRBK21.04465326
38NTRK21.04087217
39TAOK31.02289915
40NME10.97395143
41CAMK2D0.97311965
42PKN10.94793716
43HIPK20.94584644
44MAPKAPK30.93343627
45PASK0.92351602
46OBSCN0.89420122
47MAPK70.88717603
48TEC0.87199189
49FLT30.87112365
50ERBB30.83722037
51NLK0.83435680
52MYLK0.82293506
53CAMK10.80525072
54SCYL20.80154026
55DMPK0.79742106
56STK380.78408854
57PRKAA20.77386732
58PIK3CA0.75063749
59MAP4K20.75015468
60STK40.68394477
61MAP3K110.67025118
62CSNK1G30.66687658
63CSNK1G20.63849827
64MAPK130.63269633
65CSNK1G10.62950552
66PIM20.61939429
67PRKAA10.61846397
68PRKACA0.59933613
69MAP2K40.57375375
70CDC70.55902093
71STK110.53655810
72FGFR30.53619445
73PRKCG0.51650629
74CAMK2A0.51352731
75MAP2K60.49571435
76ARAF0.48995690
77EPHA40.48940053
78KIT0.48041574
79ROCK10.47017847
80IKBKB0.46542907
81EPHA30.44982967
82PRKG20.44119092
83PRKG10.43874978
84MAPK150.43593345
85PRKCA0.43103154
86CSNK2A20.41941565
87PRKCQ0.41791107
88CAMK2G0.41169940
89CSNK1A10.40847577
90PRKD20.40141659
91DAPK20.38884978
92PRKCZ0.37783862
93DYRK20.37123901
94PRKACG0.36943168
95EPHB20.36098744
96TGFBR10.35574788
97PTK2B0.35247531
98ZAK0.34828081
99PRKDC0.34357152
100PRKD10.33961471

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.13639748
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.74177396
3Butanoate metabolism_Homo sapiens_hsa006503.28117747
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.02692565
5Protein export_Homo sapiens_hsa030602.56289325
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.39238055
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.31608754
8Regulation of autophagy_Homo sapiens_hsa041402.21762701
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.14780248
10Peroxisome_Homo sapiens_hsa041462.06513243
11Propanoate metabolism_Homo sapiens_hsa006401.91672924
12Oxidative phosphorylation_Homo sapiens_hsa001901.89106111
13Sulfur metabolism_Homo sapiens_hsa009201.83373054
14Circadian rhythm_Homo sapiens_hsa047101.73067718
15Fatty acid elongation_Homo sapiens_hsa000621.68382549
16Insulin secretion_Homo sapiens_hsa049111.67440966
17Cardiac muscle contraction_Homo sapiens_hsa042601.64194670
18Tryptophan metabolism_Homo sapiens_hsa003801.51565831
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.42783369
20Fatty acid metabolism_Homo sapiens_hsa012121.40433868
21Parkinsons disease_Homo sapiens_hsa050121.39579662
22Fatty acid degradation_Homo sapiens_hsa000711.37231139
23ABC transporters_Homo sapiens_hsa020101.36218483
24Basal transcription factors_Homo sapiens_hsa030221.35887317
25Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.35485762
26Chemical carcinogenesis_Homo sapiens_hsa052041.35055725
27Primary bile acid biosynthesis_Homo sapiens_hsa001201.33683851
28Linoleic acid metabolism_Homo sapiens_hsa005911.30561092
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.21864049
30Arachidonic acid metabolism_Homo sapiens_hsa005901.19736934
31Ribosome_Homo sapiens_hsa030101.17297033
32Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.15283179
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.14724415
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.12654032
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.12518448
36Non-homologous end-joining_Homo sapiens_hsa034501.12358579
37Olfactory transduction_Homo sapiens_hsa047401.11672666
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.09436252
39beta-Alanine metabolism_Homo sapiens_hsa004101.07249462
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.05087051
41Mineral absorption_Homo sapiens_hsa049781.04682089
42Collecting duct acid secretion_Homo sapiens_hsa049661.02274166
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.01129529
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.00623080
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.98569715
46RNA degradation_Homo sapiens_hsa030180.98399508
47Phototransduction_Homo sapiens_hsa047440.97642383
48Retinol metabolism_Homo sapiens_hsa008300.95038547
49Homologous recombination_Homo sapiens_hsa034400.93393705
50Huntingtons disease_Homo sapiens_hsa050160.92589811
51Alzheimers disease_Homo sapiens_hsa050100.91326239
52Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90618348
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.90561874
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89031363
55Nicotine addiction_Homo sapiens_hsa050330.88170720
56Glycosaminoglycan degradation_Homo sapiens_hsa005310.85222794
57Ether lipid metabolism_Homo sapiens_hsa005650.84472207
58Pentose phosphate pathway_Homo sapiens_hsa000300.80040585
59Caffeine metabolism_Homo sapiens_hsa002320.78743954
60Nitrogen metabolism_Homo sapiens_hsa009100.78736704
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78135579
62Cyanoamino acid metabolism_Homo sapiens_hsa004600.76348918
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.75877114
64Glutathione metabolism_Homo sapiens_hsa004800.73797002
65Base excision repair_Homo sapiens_hsa034100.71912585
66Renin secretion_Homo sapiens_hsa049240.71461659
67Dorso-ventral axis formation_Homo sapiens_hsa043200.70402553
68Metabolic pathways_Homo sapiens_hsa011000.70163590
69Taste transduction_Homo sapiens_hsa047420.68599051
70Folate biosynthesis_Homo sapiens_hsa007900.66584907
71Selenocompound metabolism_Homo sapiens_hsa004500.65929546
72Bile secretion_Homo sapiens_hsa049760.63173532
73Amphetamine addiction_Homo sapiens_hsa050310.63151689
74Ovarian steroidogenesis_Homo sapiens_hsa049130.60802706
75One carbon pool by folate_Homo sapiens_hsa006700.60678352
76Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59742672
77Glucagon signaling pathway_Homo sapiens_hsa049220.56001196
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55200327
79Fanconi anemia pathway_Homo sapiens_hsa034600.54849666
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54203632
81Dopaminergic synapse_Homo sapiens_hsa047280.54045061
82Salivary secretion_Homo sapiens_hsa049700.53860761
83Lysine degradation_Homo sapiens_hsa003100.48923681
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.48026049
85Glutamatergic synapse_Homo sapiens_hsa047240.47988746
86Pancreatic secretion_Homo sapiens_hsa049720.47631822
87Starch and sucrose metabolism_Homo sapiens_hsa005000.46473749
88GABAergic synapse_Homo sapiens_hsa047270.45542728
89Oocyte meiosis_Homo sapiens_hsa041140.44837720
90Pyruvate metabolism_Homo sapiens_hsa006200.42604016
91Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42595752
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41625641
93RNA polymerase_Homo sapiens_hsa030200.41233837
94Arginine and proline metabolism_Homo sapiens_hsa003300.40530026
95Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.37638429
96Synaptic vesicle cycle_Homo sapiens_hsa047210.34448118
97Hedgehog signaling pathway_Homo sapiens_hsa043400.32982606
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.32796044
99Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.28540580
100Dilated cardiomyopathy_Homo sapiens_hsa054140.27909702

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