C18ORF54

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromatin remodeling at centromere (GO:0031055)5.71775891
2CENP-A containing nucleosome assembly (GO:0034080)5.52331106
3DNA double-strand break processing (GO:0000729)5.51042424
4mitotic metaphase plate congression (GO:0007080)5.14189920
5histone exchange (GO:0043486)4.97998371
6sister chromatid segregation (GO:0000819)4.96541363
7mitotic sister chromatid segregation (GO:0000070)4.91242407
8kinetochore organization (GO:0051383)4.83922585
9protein localization to kinetochore (GO:0034501)4.78736601
10metaphase plate congression (GO:0051310)4.74795816
11regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.60719956
12replication fork processing (GO:0031297)4.53115804
13establishment of integrated proviral latency (GO:0075713)4.52266183
14DNA ligation (GO:0006266)4.50154738
15DNA replication-independent nucleosome assembly (GO:0006336)4.47746765
16DNA replication-independent nucleosome organization (GO:0034724)4.47746765
17negative regulation of DNA-dependent DNA replication (GO:2000104)4.47594407
18mitotic sister chromatid cohesion (GO:0007064)4.39735564
19DNA replication checkpoint (GO:0000076)4.35395095
20spindle checkpoint (GO:0031577)4.28373444
21kinetochore assembly (GO:0051382)4.23259749
22mitotic spindle checkpoint (GO:0071174)4.10318390
23negative regulation of mitotic metaphase/anaphase transition (GO:0045841)4.07321464
24negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)4.07321464
25negative regulation of mitotic sister chromatid segregation (GO:0033048)4.07321464
26negative regulation of mitotic sister chromatid separation (GO:2000816)4.07321464
27negative regulation of sister chromatid segregation (GO:0033046)4.07321464
28negative regulation of chromosome segregation (GO:0051985)4.06868292
29regulation of centriole replication (GO:0046599)4.04351618
30nuclear pore complex assembly (GO:0051292)3.95554600
31establishment of chromosome localization (GO:0051303)3.92733911
32regulation of mitotic metaphase/anaphase transition (GO:0030071)3.91472760
33regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.91472760
34protein localization to chromosome, centromeric region (GO:0071459)3.89208646
35regulation of chromosome segregation (GO:0051983)3.86764947
36telomere maintenance via semi-conservative replication (GO:0032201)3.85246438
37double-strand break repair via nonhomologous end joining (GO:0006303)3.84661538
38non-recombinational repair (GO:0000726)3.84661538
39DNA strand elongation involved in DNA replication (GO:0006271)3.80746711
40regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.79550765
41regulation of mitotic spindle checkpoint (GO:1903504)3.79550765
42mitotic chromosome condensation (GO:0007076)3.79049275
43negative regulation of DNA recombination (GO:0045910)3.79041767
44DNA replication-dependent nucleosome assembly (GO:0006335)3.78880482
45DNA replication-dependent nucleosome organization (GO:0034723)3.78880482
46mitotic spindle assembly checkpoint (GO:0007094)3.77774651
47maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.77027698
48regulation of mitotic sister chromatid separation (GO:0010965)3.76930389
49regulation of mitotic sister chromatid segregation (GO:0033047)3.76930389
50regulation of sister chromatid segregation (GO:0033045)3.76930389
51mitotic G2/M transition checkpoint (GO:0044818)3.76264782
52mitotic recombination (GO:0006312)3.75316972
53spindle assembly checkpoint (GO:0071173)3.72978528
54nuclear pore organization (GO:0006999)3.69729655
55synapsis (GO:0007129)3.66755491
56attachment of spindle microtubules to kinetochore (GO:0008608)3.63457359
57microtubule depolymerization (GO:0007019)3.63146974
58DNA strand elongation (GO:0022616)3.60913169
59DNA catabolic process, exonucleolytic (GO:0000738)3.60161629
60DNA strand renaturation (GO:0000733)3.54998248
61DNA topological change (GO:0006265)3.52034732
62regulation of DNA endoreduplication (GO:0032875)3.49791864
63meiotic chromosome segregation (GO:0045132)3.48241668
64chromosome segregation (GO:0007059)3.48149865
65resolution of meiotic recombination intermediates (GO:0000712)3.47856596
66somatic diversification of immune receptors via somatic mutation (GO:0002566)3.47785225
67somatic hypermutation of immunoglobulin genes (GO:0016446)3.47785225
68mitotic nuclear envelope disassembly (GO:0007077)3.43678257
69telomere maintenance via recombination (GO:0000722)3.42700625
70regulation of centrosome cycle (GO:0046605)3.34664494
71ATP-dependent chromatin remodeling (GO:0043044)3.32784128
72IMP biosynthetic process (GO:0006188)3.31740534
73establishment of viral latency (GO:0019043)3.31527621
74response to X-ray (GO:0010165)3.28261712
75regulation of nuclear cell cycle DNA replication (GO:0033262)3.27400769
76purine nucleobase biosynthetic process (GO:0009113)3.26509607
77centriole replication (GO:0007099)3.24990717
78negative regulation of mitosis (GO:0045839)3.23270443
79DNA unwinding involved in DNA replication (GO:0006268)3.19928747
80regulation of spindle organization (GO:0090224)3.17223679
81nucleotide-excision repair, DNA gap filling (GO:0006297)3.16826375
82nuclear envelope disassembly (GO:0051081)3.16435759
83membrane disassembly (GO:0030397)3.16435759
84heterochromatin organization (GO:0070828)3.10156934
85somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.08848040
86isotype switching (GO:0045190)3.08848040
87somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.08848040
88protein K6-linked ubiquitination (GO:0085020)3.07973586
89mitotic G2 DNA damage checkpoint (GO:0007095)3.06285382
90proteasome assembly (GO:0043248)3.05420705
91chromatin assembly or disassembly (GO:0006333)3.04541870
92cullin deneddylation (GO:0010388)3.04415089
93microtubule polymerization or depolymerization (GO:0031109)3.04199897
94regulation of helicase activity (GO:0051095)3.04048085
95protein localization to chromosome (GO:0034502)3.01482610
96regulation of meiosis I (GO:0060631)3.01447619
97regulation of centrosome duplication (GO:0010824)3.00777451
98nucleobase biosynthetic process (GO:0046112)2.99580559
99telomere maintenance via telomere lengthening (GO:0010833)2.98918495
100recombinational repair (GO:0000725)2.98618056

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.28144611
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.20189597
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.81734194
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.73146971
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.55530505
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.51817053
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.27447560
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.72037220
9* AR_21909140_ChIP-Seq_LNCAP_Human2.65675473
10KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.57386903
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.45122021
12ELK1_19687146_ChIP-ChIP_HELA_Human2.44743219
13EWS_26573619_Chip-Seq_HEK293_Human2.16629475
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.16040576
15FUS_26573619_Chip-Seq_HEK293_Human2.14052836
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.13372645
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.09024336
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.06720484
19POU5F1_16153702_ChIP-ChIP_HESCs_Human1.99118804
20E2F1_21310950_ChIP-Seq_MCF-7_Human1.96926741
21ZNF274_21170338_ChIP-Seq_K562_Hela1.95225188
22PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93477388
23* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.89981898
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.80871230
25VDR_22108803_ChIP-Seq_LS180_Human1.79900594
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.69964481
27MYC_19030024_ChIP-ChIP_MESCs_Mouse1.69760524
28* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.64380644
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.63925016
30FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.59711466
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.59482196
32NANOG_16153702_ChIP-ChIP_HESCs_Human1.55122476
33P300_19829295_ChIP-Seq_ESCs_Human1.54504883
34FOXP3_21729870_ChIP-Seq_TREG_Human1.53549268
35TAF15_26573619_Chip-Seq_HEK293_Human1.53236913
36YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53069591
37MYC_18940864_ChIP-ChIP_HL60_Human1.52776386
38MYCN_18555785_ChIP-Seq_MESCs_Mouse1.52487582
39IGF1R_20145208_ChIP-Seq_DFB_Human1.52483132
40MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.51580097
41VDR_23849224_ChIP-Seq_CD4+_Human1.49696099
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.49290736
43RBPJ_22232070_ChIP-Seq_NCS_Mouse1.48133025
44SOX2_16153702_ChIP-ChIP_HESCs_Human1.44276274
45NELFA_20434984_ChIP-Seq_ESCs_Mouse1.43012849
46MYC_19079543_ChIP-ChIP_MESCs_Mouse1.41539948
47ETS1_20019798_ChIP-Seq_JURKAT_Human1.38929072
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.37785729
49TP63_19390658_ChIP-ChIP_HaCaT_Human1.31246938
50GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.29957137
51JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.26644409
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24826208
53SOX2_18555785_ChIP-Seq_MESCs_Mouse1.22402265
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21856343
55E2F1_18555785_ChIP-Seq_MESCs_Mouse1.21040676
56IRF1_19129219_ChIP-ChIP_H3396_Human1.18524439
57MYC_18358816_ChIP-ChIP_MESCs_Mouse1.18025522
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.17936008
59NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.17341107
60DCP1A_22483619_ChIP-Seq_HELA_Human1.16935300
61HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.16527218
62NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.16112228
63CTBP2_25329375_ChIP-Seq_LNCAP_Human1.14914228
64PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.12564910
65GBX2_23144817_ChIP-Seq_PC3_Human1.12105341
66TTF2_22483619_ChIP-Seq_HELA_Human1.11586546
67HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11195985
68HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.07284052
69ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06864390
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01909068
71POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.99275424
72* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98505619
73* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98287999
74E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97783740
75POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.97407585
76RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.96097021
77ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.95179014
78CTBP1_25329375_ChIP-Seq_LNCAP_Human0.95130029
79MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94476317
80EZH2_27294783_Chip-Seq_NPCs_Mouse0.94414641
81SMAD3_21741376_ChIP-Seq_EPCs_Human0.91525238
82UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89915526
83CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.88779684
84SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.88465479
85GABP_19822575_ChIP-Seq_HepG2_Human0.87605006
86NOTCH1_21737748_ChIP-Seq_TLL_Human0.86356418
87SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85106043
88OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84419899
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.83173984
90SUZ12_27294783_Chip-Seq_NPCs_Mouse0.82929559
91NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.82397285
92ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.82289195
93KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.82089479
94KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.82089479
95KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.82089479
96SRF_21415370_ChIP-Seq_HL-1_Mouse0.81980398
97SOX9_26525672_Chip-Seq_HEART_Mouse0.81559804
98NANOG_18555785_ChIP-Seq_MESCs_Mouse0.81432042
99BCAT_22108803_ChIP-Seq_LS180_Human0.81215864
100SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.81121850

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.68783663
2MP0003693_abnormal_embryo_hatching3.88791000
3MP0008058_abnormal_DNA_repair3.68323050
4MP0008057_abnormal_DNA_replication3.53380435
5MP0004957_abnormal_blastocyst_morpholog3.50701141
6MP0003111_abnormal_nucleus_morphology3.41506852
7MP0003890_abnormal_embryonic-extraembry3.08197599
8MP0003077_abnormal_cell_cycle2.93537393
9MP0008877_abnormal_DNA_methylation2.74538251
10MP0008932_abnormal_embryonic_tissue2.72184798
11MP0006292_abnormal_olfactory_placode2.59054296
12MP0009697_abnormal_copulation2.53863513
13MP0003941_abnormal_skin_development2.35739986
14MP0008007_abnormal_cellular_replicative2.31751717
15MP0001293_anophthalmia2.10485651
16MP0003718_maternal_effect2.03811367
17MP0003937_abnormal_limbs/digits/tail_de1.92271490
18MP0003121_genomic_imprinting1.91294557
19MP0002102_abnormal_ear_morphology1.90362431
20MP0003136_yellow_coat_color1.73298599
21MP0002938_white_spotting1.69731669
22MP0010307_abnormal_tumor_latency1.69402650
23MP0003119_abnormal_digestive_system1.68689581
24MP0003123_paternal_imprinting1.59024756
25MP0003786_premature_aging1.57418985
26MP0003567_abnormal_fetal_cardiomyocyte1.50798276
27MP0002233_abnormal_nose_morphology1.50638182
28MP0009672_abnormal_birth_weight1.47603468
29MP0001730_embryonic_growth_arrest1.47552666
30MP0002084_abnormal_developmental_patter1.46435520
31MP0006072_abnormal_retinal_apoptosis1.43391623
32MP0002085_abnormal_embryonic_tissue1.41323324
33MP0001188_hyperpigmentation1.41195243
34MP0001697_abnormal_embryo_size1.39582793
35MP0010030_abnormal_orbit_morphology1.38452375
36MP0001672_abnormal_embryogenesis/_devel1.34210757
37MP0005380_embryogenesis_phenotype1.34210757
38MP0002751_abnormal_autonomic_nervous1.34043360
39MP0000350_abnormal_cell_proliferation1.32849235
40MP0004197_abnormal_fetal_growth/weight/1.30840842
41MP0001286_abnormal_eye_development1.30430668
42MP0001529_abnormal_vocalization1.28438385
43MP0008789_abnormal_olfactory_epithelium1.27696401
44MP0010352_gastrointestinal_tract_polyps1.26199874
45MP0001929_abnormal_gametogenesis1.24043170
46MP0005394_taste/olfaction_phenotype1.23469556
47MP0005499_abnormal_olfactory_system1.23469556
48MP0002210_abnormal_sex_determination1.21516360
49MP0009703_decreased_birth_body1.20886546
50MP0003787_abnormal_imprinting1.18094021
51MP0002697_abnormal_eye_size1.16922454
52MP0000516_abnormal_urinary_system1.16506433
53MP0005367_renal/urinary_system_phenotyp1.16506433
54MP0000372_irregular_coat_pigmentation1.14397560
55MP0003755_abnormal_palate_morphology1.11602595
56MP0002111_abnormal_tail_morphology1.08837925
57MP0001177_atelectasis1.07835399
58MP0003984_embryonic_growth_retardation1.07010583
59MP0001145_abnormal_male_reproductive1.05553474
60MP0002088_abnormal_embryonic_growth/wei1.05237754
61MP0000653_abnormal_sex_gland1.05112474
62MP0000428_abnormal_craniofacial_morphol1.05098606
63MP0002736_abnormal_nociception_after1.04804212
64MP0002080_prenatal_lethality1.04644251
65MP0000647_abnormal_sebaceous_gland1.01736426
66MP0005248_abnormal_Harderian_gland0.98894419
67MP0003122_maternal_imprinting0.98348463
68MP0001119_abnormal_female_reproductive0.97228034
69MP0000049_abnormal_middle_ear0.96351585
70MP0003880_abnormal_central_pattern0.95290499
71MP0004133_heterotaxia0.94019140
72MP0006054_spinal_hemorrhage0.92740033
73MP0003861_abnormal_nervous_system0.92138677
74MP0005253_abnormal_eye_physiology0.90331181
75MP0003698_abnormal_male_reproductive0.86978297
76MP0003935_abnormal_craniofacial_develop0.86020694
77MP0001485_abnormal_pinna_reflex0.83401561
78MP0002086_abnormal_extraembryonic_tissu0.82820695
79MP0006035_abnormal_mitochondrial_morpho0.82539697
80MP0001299_abnormal_eye_distance/0.81959451
81MP0008995_early_reproductive_senescence0.81201124
82MP0000313_abnormal_cell_death0.80952459
83MP0005391_vision/eye_phenotype0.80128658
84MP0005171_absent_coat_pigmentation0.78905976
85MP0005395_other_phenotype0.78528972
86MP0003195_calcinosis0.77727501
87MP0000432_abnormal_head_morphology0.77415283
88MP0003385_abnormal_body_wall0.77022422
89MP0002254_reproductive_system_inflammat0.75293932
90MP0002160_abnormal_reproductive_system0.75113268
91MP0002234_abnormal_pharynx_morphology0.74763699
92MP0009250_abnormal_appendicular_skeleto0.73866736
93MP0000358_abnormal_cell_content/0.73749364
94MP0003943_abnormal_hepatobiliary_system0.71417603
95MP0000579_abnormal_nail_morphology0.71132992
96MP0003315_abnormal_perineum_morphology0.70928424
97MP0000537_abnormal_urethra_morphology0.70689158
98MP0000778_abnormal_nervous_system0.67311056
99MP0004215_abnormal_myocardial_fiber0.67115691
100MP0001984_abnormal_olfaction0.67024591

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.77121033
2Chromsome breakage (HP:0040012)4.45615225
3Abnormality of chromosome stability (HP:0003220)4.38923280
4Meckel diverticulum (HP:0002245)4.29796804
5Abnormality of the ileum (HP:0001549)4.18183243
6Aplasia/Hypoplasia of the uvula (HP:0010293)4.15513982
7Volvulus (HP:0002580)4.04125095
8Colon cancer (HP:0003003)3.97963990
9Abnormality of the labia minora (HP:0012880)3.85033641
10Small intestinal stenosis (HP:0012848)3.63645055
11Duodenal stenosis (HP:0100867)3.63645055
12Abnormal lung lobation (HP:0002101)3.55736625
13Abnormality of the preputium (HP:0100587)3.54476809
14Abnormality of the duodenum (HP:0002246)3.28846887
15Embryonal renal neoplasm (HP:0011794)3.22205486
16Nephroblastoma (Wilms tumor) (HP:0002667)3.14473256
17Ectopic kidney (HP:0000086)3.11375900
18Cortical dysplasia (HP:0002539)2.95542763
19Ependymoma (HP:0002888)2.83314382
20Septo-optic dysplasia (HP:0100842)2.78358581
21Rhabdomyosarcoma (HP:0002859)2.75939628
22Sloping forehead (HP:0000340)2.73690199
23Triphalangeal thumb (HP:0001199)2.68404833
24Absent radius (HP:0003974)2.66178974
25Myelodysplasia (HP:0002863)2.60480534
26Birth length less than 3rd percentile (HP:0003561)2.59453231
27Intestinal atresia (HP:0011100)2.59244015
28Abnormality of the carotid arteries (HP:0005344)2.58013807
29Clubbing of toes (HP:0100760)2.57666029
30Increased nuchal translucency (HP:0010880)2.56733901
31Aplasia involving forearm bones (HP:0009822)2.50657691
32Absent forearm bone (HP:0003953)2.50657691
33Supernumerary spleens (HP:0009799)2.44901700
34Glioma (HP:0009733)2.44048400
35Medulloblastoma (HP:0002885)2.38100385
36Neoplasm of the colon (HP:0100273)2.25062262
37Pancreatic islet-cell hyperplasia (HP:0004510)2.23001347
38Abnormality of the astrocytes (HP:0100707)2.18245510
39Astrocytoma (HP:0009592)2.18245510
40Horseshoe kidney (HP:0000085)2.06082437
41Stenosis of the external auditory canal (HP:0000402)2.01523478
42Absent thumb (HP:0009777)2.01106316
43Arteriovenous malformation (HP:0100026)2.00102173
44Bifid tongue (HP:0010297)1.99132342
45Hyperglycinemia (HP:0002154)1.99064609
46Absent septum pellucidum (HP:0001331)1.96592246
47Neoplasm of the adrenal cortex (HP:0100641)1.94437997
48Aqueductal stenosis (HP:0002410)1.94389185
49Cafe-au-lait spot (HP:0000957)1.93409208
50Abnormality of the septum pellucidum (HP:0007375)1.92251429
51Aplasia/Hypoplasia of the sternum (HP:0006714)1.91473391
52Oligodactyly (hands) (HP:0001180)1.88062391
53Neoplasm of the oral cavity (HP:0100649)1.87974353
54Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.85019162
55Dandy-Walker malformation (HP:0001305)1.84119039
56Embryonal neoplasm (HP:0002898)1.83148451
57Neoplasm of striated muscle (HP:0009728)1.82051011
58Astigmatism (HP:0000483)1.81966274
59Ovarian neoplasm (HP:0100615)1.81945451
60Agnosia (HP:0010524)1.81283290
61Gastrointestinal atresia (HP:0002589)1.79899662
62Choanal atresia (HP:0000453)1.79424295
63Small hand (HP:0200055)1.79059562
64Gonadotropin excess (HP:0000837)1.78669216
65Abnormality of aspartate family amino acid metabolism (HP:0010899)1.77737323
66Preaxial hand polydactyly (HP:0001177)1.76899335
67Abnormal hair whorl (HP:0010721)1.76725665
68Biliary tract neoplasm (HP:0100574)1.76393683
69Carpal bone hypoplasia (HP:0001498)1.75180382
70Abnormality of serum amino acid levels (HP:0003112)1.74710694
71Pancreatic cysts (HP:0001737)1.74431210
72Abnormality of methionine metabolism (HP:0010901)1.73496577
73Hypoplastic pelvis (HP:0008839)1.72620151
74Optic nerve hypoplasia (HP:0000609)1.72390800
75Duplicated collecting system (HP:0000081)1.71452731
76Abnormal umbilical cord blood vessels (HP:0011403)1.68886401
77Single umbilical artery (HP:0001195)1.68886401
78Abnormality of the fetal cardiovascular system (HP:0010948)1.68886401
79Neoplasm of the adrenal gland (HP:0100631)1.68630861
80Abnormality of glycine metabolism (HP:0010895)1.68293022
81Abnormality of serine family amino acid metabolism (HP:0010894)1.68293022
82Renal hypoplasia (HP:0000089)1.66124970
83Pancreatic fibrosis (HP:0100732)1.65947063
84Nephronophthisis (HP:0000090)1.65702512
85Rectal fistula (HP:0100590)1.62302311
86Rectovaginal fistula (HP:0000143)1.62302311
87Long clavicles (HP:0000890)1.62170748
88True hermaphroditism (HP:0010459)1.61956056
89Short thumb (HP:0009778)1.61415472
90Oligohydramnios (HP:0001562)1.59747614
91Spastic diplegia (HP:0001264)1.58929152
92Hypoplastic female external genitalia (HP:0012815)1.58835055
93Abnormality of midbrain morphology (HP:0002418)1.58630259
94Molar tooth sign on MRI (HP:0002419)1.58630259
95Aplasia/Hypoplasia of the sacrum (HP:0008517)1.58054744
96Neoplasm of the small intestine (HP:0100833)1.56483306
97Hyperglycinuria (HP:0003108)1.56357674
98Hemivertebrae (HP:0002937)1.56286418
99Breast carcinoma (HP:0003002)1.55485986
100Abnormal auditory evoked potentials (HP:0006958)1.53725643

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.39310642
2TTK3.27633761
3MKNK23.14986747
4PLK43.14241570
5CDC73.08758679
6WEE12.92462512
7NEK12.77996732
8PLK32.62016761
9MKNK12.61982629
10TRIM282.48809807
11TNIK2.45765668
12ACVR1B2.44199404
13WNK32.27836852
14ZAK2.27298648
15BRSK22.25715664
16BMPR1B2.23947200
17TSSK62.23161917
18PBK2.21549951
19NUAK12.19414283
20SRPK12.17294147
21EIF2AK31.98449664
22PNCK1.85384756
23PLK11.73799191
24TAF11.72719913
25EIF2AK11.63614861
26PLK21.60932444
27VRK21.56777415
28MST41.55269945
29NEK21.54786901
30MAP4K21.52468240
31ERBB31.50780357
32VRK11.35679565
33BRSK11.29306329
34ATR1.14849540
35STK31.14655971
36TGFBR11.13649797
37CCNB11.13168742
38CHEK21.12668049
39BCR1.09667477
40FRK1.04329376
41EIF2AK20.96176989
42AURKB0.92538675
43ATM0.88269601
44ERBB40.87837999
45LATS10.87495875
46STK160.83954823
47BRD40.82603390
48STK38L0.79965105
49CASK0.79072900
50CSNK1G10.74349997
51DYRK30.74002331
52FLT30.73890782
53MELK0.72892133
54CHEK10.70736526
55BRAF0.69396362
56MAPK130.65811109
57STK390.61393104
58NLK0.61384246
59FGFR10.59400835
60PASK0.56949015
61FGFR20.55667371
62CDK70.55544132
63TIE10.54749554
64EPHA40.54285307
65STK100.53070048
66MAP3K40.52214977
67CDK10.51348971
68OXSR10.51033600
69NME10.50711205
70DYRK20.49224934
71CSNK1G20.49205222
72MAP3K100.47526072
73AKT30.46527819
74GRK10.44456870
75PRKD30.43548641
76CSNK1G30.42679135
77PRKDC0.41511588
78RPS6KA40.40652594
79MAP3K80.39105244
80STK40.38475967
81YES10.38057864
82CDK20.37954746
83CDK190.36064210
84INSRR0.35179265
85CSNK2A10.35073189
86MINK10.34715153
87BCKDK0.33922155
88CSNK1A1L0.31819271
89CLK10.30958860
90CSNK1E0.30798893
91CDK30.30070352
92AURKA0.30059006
93PRKCG0.29772424
94SIK30.29315169
95CDK90.28748432
96CAMK1G0.28180289
97ALK0.26383865
98CSNK2A20.25657979
99CDK80.22314750
100PDK20.22128539

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034504.36355306
2Mismatch repair_Homo sapiens_hsa034304.25212261
3DNA replication_Homo sapiens_hsa030303.79336376
4Homologous recombination_Homo sapiens_hsa034403.42846247
5Fanconi anemia pathway_Homo sapiens_hsa034603.36078418
6Proteasome_Homo sapiens_hsa030502.91303124
7Cell cycle_Homo sapiens_hsa041102.84785686
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.63226430
9Base excision repair_Homo sapiens_hsa034102.54628926
10RNA transport_Homo sapiens_hsa030132.52252583
11Basal transcription factors_Homo sapiens_hsa030222.24200915
12Nucleotide excision repair_Homo sapiens_hsa034202.18961576
13Protein export_Homo sapiens_hsa030602.04618841
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.03072537
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.01398905
16RNA degradation_Homo sapiens_hsa030181.98185956
17Spliceosome_Homo sapiens_hsa030401.97352109
18Propanoate metabolism_Homo sapiens_hsa006401.96179118
19Steroid biosynthesis_Homo sapiens_hsa001001.92738003
20RNA polymerase_Homo sapiens_hsa030201.85619029
21One carbon pool by folate_Homo sapiens_hsa006701.70106507
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.65206030
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.61542316
24Oocyte meiosis_Homo sapiens_hsa041141.57678281
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.46856803
26mRNA surveillance pathway_Homo sapiens_hsa030151.45684645
27Selenocompound metabolism_Homo sapiens_hsa004501.42756866
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36441067
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.35597013
30p53 signaling pathway_Homo sapiens_hsa041151.33904255
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31614038
32Pyrimidine metabolism_Homo sapiens_hsa002401.28431078
33Vitamin B6 metabolism_Homo sapiens_hsa007501.27347018
34Fatty acid elongation_Homo sapiens_hsa000621.23352286
35Pyruvate metabolism_Homo sapiens_hsa006201.22990048
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.19561705
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.16120047
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.15711424
39Purine metabolism_Homo sapiens_hsa002301.05798629
40TGF-beta signaling pathway_Homo sapiens_hsa043500.99013764
41Basal cell carcinoma_Homo sapiens_hsa052170.96775904
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.96112959
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.93316975
44Hippo signaling pathway_Homo sapiens_hsa043900.93156290
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.92444690
46Biosynthesis of amino acids_Homo sapiens_hsa012300.91524592
47Hedgehog signaling pathway_Homo sapiens_hsa043400.88442219
48Lysine degradation_Homo sapiens_hsa003100.81442615
49Wnt signaling pathway_Homo sapiens_hsa043100.78571642
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78302678
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.77283166
52Carbon metabolism_Homo sapiens_hsa012000.73296967
53Phototransduction_Homo sapiens_hsa047440.71071836
54Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68208501
55Butanoate metabolism_Homo sapiens_hsa006500.68075425
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65050817
57Glutathione metabolism_Homo sapiens_hsa004800.64571299
58Huntingtons disease_Homo sapiens_hsa050160.63733810
59Fatty acid metabolism_Homo sapiens_hsa012120.63576597
60Parkinsons disease_Homo sapiens_hsa050120.62920254
61Adherens junction_Homo sapiens_hsa045200.56405957
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54022439
63MicroRNAs in cancer_Homo sapiens_hsa052060.50799891
64Fatty acid degradation_Homo sapiens_hsa000710.48868728
65Metabolic pathways_Homo sapiens_hsa011000.45101894
66Folate biosynthesis_Homo sapiens_hsa007900.44945523
67N-Glycan biosynthesis_Homo sapiens_hsa005100.44428940
68Colorectal cancer_Homo sapiens_hsa052100.42781226
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41908972
70Oxidative phosphorylation_Homo sapiens_hsa001900.37395076
71beta-Alanine metabolism_Homo sapiens_hsa004100.37158490
72Tight junction_Homo sapiens_hsa045300.36235091
73Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.32936284
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31426264
75Peroxisome_Homo sapiens_hsa041460.31017471
76Olfactory transduction_Homo sapiens_hsa047400.28624127
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28373333
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28136872
79Tryptophan metabolism_Homo sapiens_hsa003800.26294169
80Ribosome_Homo sapiens_hsa030100.25820456
81Retinol metabolism_Homo sapiens_hsa008300.25090146
82Thyroid cancer_Homo sapiens_hsa052160.22753714
83Epstein-Barr virus infection_Homo sapiens_hsa051690.20126876
84Caffeine metabolism_Homo sapiens_hsa002320.19485783
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.19048092
86Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.18795516
87Nitrogen metabolism_Homo sapiens_hsa009100.17562327
88Vitamin digestion and absorption_Homo sapiens_hsa049770.16880721
89Melanoma_Homo sapiens_hsa052180.16816408
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.16330974
91Arginine and proline metabolism_Homo sapiens_hsa003300.15246194
92Prostate cancer_Homo sapiens_hsa052150.14876697
93Sulfur metabolism_Homo sapiens_hsa009200.14614752
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.14522228
95Alcoholism_Homo sapiens_hsa050340.11986930
96Nicotine addiction_Homo sapiens_hsa050330.11900364
97Regulation of autophagy_Homo sapiens_hsa041400.09787403
98Alzheimers disease_Homo sapiens_hsa050100.09405349
99Melanogenesis_Homo sapiens_hsa049160.09378337
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.08179705

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