C18ORF32

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.11324404
2nucleobase catabolic process (GO:0046113)4.31252781
3neuron cell-cell adhesion (GO:0007158)4.30394785
4gamma-aminobutyric acid transport (GO:0015812)4.27916545
5protein localization to cilium (GO:0061512)4.04348054
6presynaptic membrane assembly (GO:0097105)4.03401033
7presynaptic membrane organization (GO:0097090)3.88823047
8behavioral response to nicotine (GO:0035095)3.80824949
9postsynaptic membrane organization (GO:0001941)3.77440164
10negative regulation of synaptic transmission, GABAergic (GO:0032229)3.73165452
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.58411254
12regulation of synapse structural plasticity (GO:0051823)3.57074445
13vocalization behavior (GO:0071625)3.49723448
14synapse assembly (GO:0007416)3.49501164
15positive regulation of mitochondrial fission (GO:0090141)3.48653123
16ionotropic glutamate receptor signaling pathway (GO:0035235)3.45156927
17auditory behavior (GO:0031223)3.34189302
18synaptic vesicle maturation (GO:0016188)3.32566503
19nonmotile primary cilium assembly (GO:0035058)3.32342294
20negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.30407540
21synaptic vesicle exocytosis (GO:0016079)3.28531544
22glycosphingolipid biosynthetic process (GO:0006688)3.28015189
23protein localization to synapse (GO:0035418)3.26788480
24synaptic transmission, glutamatergic (GO:0035249)3.25823013
25glutamate receptor signaling pathway (GO:0007215)3.20499826
26sequestering of actin monomers (GO:0042989)3.19838270
27neuronal action potential propagation (GO:0019227)3.19604972
28epithelial cilium movement (GO:0003351)3.13730799
29membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.09556155
30calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.09074961
31G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.07996980
32regulation of synaptic vesicle exocytosis (GO:2000300)3.05236079
33glutamate secretion (GO:0014047)3.02654549
34neurotransmitter-gated ion channel clustering (GO:0072578)3.00509425
35platelet dense granule organization (GO:0060155)2.99575051
36neuron-neuron synaptic transmission (GO:0007270)2.97321526
37transmission of nerve impulse (GO:0019226)2.97118571
38neurotransmitter secretion (GO:0007269)2.92605917
39regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.91022378
40regulation of synaptic vesicle transport (GO:1902803)2.90532365
41axonal fasciculation (GO:0007413)2.88557264
42regulation of cilium movement (GO:0003352)2.88122195
43dendritic spine morphogenesis (GO:0060997)2.87996737
44startle response (GO:0001964)2.87236427
45regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.84256079
46regulation of synaptic transmission, glutamatergic (GO:0051966)2.82726472
47response to auditory stimulus (GO:0010996)2.81379382
48positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.79140473
49regulation of respiratory system process (GO:0044065)2.77751331
50regulation of short-term neuronal synaptic plasticity (GO:0048172)2.74156530
51cilium movement (GO:0003341)2.73591076
52neuron recognition (GO:0008038)2.72539285
53establishment of mitochondrion localization (GO:0051654)2.72241379
54regulation of feeding behavior (GO:0060259)2.70843010
55neuronal action potential (GO:0019228)2.70024527
56axoneme assembly (GO:0035082)2.69847427
57positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.68727473
58cilium or flagellum-dependent cell motility (GO:0001539)2.67059550
59C4-dicarboxylate transport (GO:0015740)2.65253225
60neuromuscular synaptic transmission (GO:0007274)2.65042426
61cellular ketone body metabolic process (GO:0046950)2.63174176
62regulation of neurotransmitter levels (GO:0001505)2.62862530
63positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.62108758
64mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.62108758
65positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.61746530
66positive regulation of synapse assembly (GO:0051965)2.58940768
67regulation of action potential (GO:0098900)2.58341800
68mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.56785696
69mechanosensory behavior (GO:0007638)2.55057947
70cilium morphogenesis (GO:0060271)2.54767560
71cilium assembly (GO:0042384)2.52812978
72neural tube formation (GO:0001841)2.52285617
73negative regulation of cytosolic calcium ion concentration (GO:0051481)2.52091813
74cilium organization (GO:0044782)2.51938879
75response to dietary excess (GO:0002021)2.51502483
76synapse organization (GO:0050808)2.51202992
77positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.50957841
78synaptic transmission, cholinergic (GO:0007271)2.49971201
79detection of light stimulus involved in visual perception (GO:0050908)2.49628203
80detection of light stimulus involved in sensory perception (GO:0050962)2.49628203
81glycerophospholipid catabolic process (GO:0046475)2.49616818
82proline transport (GO:0015824)2.47637201
83intraciliary transport (GO:0042073)2.47541464
84regulation of neurotransmitter uptake (GO:0051580)2.47495464
85protein neddylation (GO:0045116)2.47249559
86membrane depolarization during action potential (GO:0086010)2.46285328
87ATP hydrolysis coupled proton transport (GO:0015991)2.43860849
88energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.43860849
89protein-cofactor linkage (GO:0018065)2.42656689
90adult walking behavior (GO:0007628)2.42203218
91regulation of collateral sprouting (GO:0048670)2.41069679
92gamma-aminobutyric acid signaling pathway (GO:0007214)2.40540468
93neurotransmitter metabolic process (GO:0042133)2.40400829
94retinal ganglion cell axon guidance (GO:0031290)2.40275017
95positive regulation of amino acid transport (GO:0051957)2.39778952
96serotonin metabolic process (GO:0042428)2.39362595
97adult behavior (GO:0030534)2.38802635
98retinal cone cell development (GO:0046549)2.38564843
99regulation of neurotransmitter transport (GO:0051588)2.38272391
100axon ensheathment in central nervous system (GO:0032291)2.37581152

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.29533688
2GBX2_23144817_ChIP-Seq_PC3_Human3.39287628
3ZNF274_21170338_ChIP-Seq_K562_Hela2.95123008
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.76338267
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.75806381
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.69796674
7IGF1R_20145208_ChIP-Seq_DFB_Human2.69301786
8TAF15_26573619_Chip-Seq_HEK293_Human2.65939742
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.46494236
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.41150631
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.39742761
12VDR_22108803_ChIP-Seq_LS180_Human2.21763280
13CTBP1_25329375_ChIP-Seq_LNCAP_Human2.09474823
14REST_21632747_ChIP-Seq_MESCs_Mouse2.07936984
15P300_19829295_ChIP-Seq_ESCs_Human1.96368902
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88279867
17SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.84354781
18FUS_26573619_Chip-Seq_HEK293_Human1.83835389
19SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.80338412
20CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.76786163
21CBX2_27304074_Chip-Seq_ESCs_Mouse1.74948896
22EWS_26573619_Chip-Seq_HEK293_Human1.73506739
23REST_18959480_ChIP-ChIP_MESCs_Mouse1.73129209
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.67041606
25SMAD4_21799915_ChIP-Seq_A2780_Human1.66274726
26PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66110395
27RNF2_27304074_Chip-Seq_NSC_Mouse1.63668150
28PIAS1_25552417_ChIP-Seq_VCAP_Human1.60490053
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.59774930
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.58716019
31OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58194628
32ER_23166858_ChIP-Seq_MCF-7_Human1.54301745
33UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.51233750
34SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.48850378
35AR_25329375_ChIP-Seq_VCAP_Human1.48217614
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.48150494
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44318440
38EZH2_27304074_Chip-Seq_ESCs_Mouse1.43938725
39JARID2_20064375_ChIP-Seq_MESCs_Mouse1.43682093
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.43363693
41MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41435296
42MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41007365
43EED_16625203_ChIP-ChIP_MESCs_Mouse1.40838501
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40744135
45TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39153563
46CBP_20019798_ChIP-Seq_JUKART_Human1.38062072
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38062072
48SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.37866400
49SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.36344945
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.33666706
51STAT3_23295773_ChIP-Seq_U87_Human1.32561341
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.30982831
53BCAT_22108803_ChIP-Seq_LS180_Human1.30109574
54POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28005625
55TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28005625
56HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.27773200
57EZH2_27294783_Chip-Seq_ESCs_Mouse1.27005139
58TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25939330
59NR3C1_21868756_ChIP-Seq_MCF10A_Human1.25575717
60NANOG_18555785_Chip-Seq_ESCs_Mouse1.24166475
61TCF4_23295773_ChIP-Seq_U87_Human1.23830646
62TP53_22573176_ChIP-Seq_HFKS_Human1.23479758
63SUZ12_27294783_Chip-Seq_ESCs_Mouse1.22604565
64SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.22235453
65JARID2_20075857_ChIP-Seq_MESCs_Mouse1.21942472
66FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.20308523
67SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.20258461
68TAL1_26923725_Chip-Seq_HPCs_Mouse1.19324654
69CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18154078
70RUNX2_22187159_ChIP-Seq_PCA_Human1.17995964
71EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17554604
72TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15432551
73TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14439248
74SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12964621
75P53_22387025_ChIP-Seq_ESCs_Mouse1.12611903
76KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12266995
77SOX2_21211035_ChIP-Seq_LN229_Gbm1.10902637
78AR_21572438_ChIP-Seq_LNCaP_Human1.08979835
79FLI1_21867929_ChIP-Seq_TH2_Mouse1.08828159
80E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.08734010
81SOX2_19829295_ChIP-Seq_ESCs_Human1.08466837
82NANOG_19829295_ChIP-Seq_ESCs_Human1.08466837
83TCF4_22108803_ChIP-Seq_LS180_Human1.08327006
84MTF2_20144788_ChIP-Seq_MESCs_Mouse1.07136635
85GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07003041
86JUN_21703547_ChIP-Seq_K562_Human1.05448925
87EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04706430
88IRF1_19129219_ChIP-ChIP_H3396_Human1.04335049
89CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03450094
90EZH2_27294783_Chip-Seq_NPCs_Mouse1.03306219
91DROSHA_22980978_ChIP-Seq_HELA_Human1.03148441
92ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.02198810
93HTT_18923047_ChIP-ChIP_STHdh_Human1.01878014
94ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01470197
95KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01240337
96PRDM14_20953172_ChIP-Seq_ESCs_Human1.00946459
97NFE2_27457419_Chip-Seq_LIVER_Mouse1.00668410
98FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97161494
99E2F1_18555785_Chip-Seq_ESCs_Mouse0.94595486
100EZH2_18974828_ChIP-Seq_MESCs_Mouse0.94421777

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.75117435
2MP0004859_abnormal_synaptic_plasticity3.04502709
3MP0004270_analgesia2.68588872
4MP0009046_muscle_twitch2.68439527
5MP0009745_abnormal_behavioral_response2.58389568
6MP0001984_abnormal_olfaction2.53483695
7MP0005423_abnormal_somatic_nervous2.50824640
8MP0003635_abnormal_synaptic_transmissio2.44743591
9MP0001968_abnormal_touch/_nociception2.44736824
10MP0002272_abnormal_nervous_system2.38212738
11MP0002064_seizures2.33913392
12MP0002102_abnormal_ear_morphology2.30290409
13MP0002735_abnormal_chemical_nociception2.30201378
14MP0001529_abnormal_vocalization2.27154593
15MP0001486_abnormal_startle_reflex2.25577737
16MP0002822_catalepsy2.23596699
17MP0002638_abnormal_pupillary_reflex2.19673033
18MP0002063_abnormal_learning/memory/cond2.18319477
19MP0002572_abnormal_emotion/affect_behav2.14024905
20MP0002736_abnormal_nociception_after2.13491730
21MP0003787_abnormal_imprinting2.11153241
22MP0006276_abnormal_autonomic_nervous2.04770613
23MP0002734_abnormal_mechanical_nocicepti2.03158795
24MP0001970_abnormal_pain_threshold1.85602280
25MP0005551_abnormal_eye_electrophysiolog1.84833083
26MP0000778_abnormal_nervous_system1.84160192
27MP0004142_abnormal_muscle_tone1.80816815
28MP0002653_abnormal_ependyma_morphology1.74402696
29MP0001501_abnormal_sleep_pattern1.73009620
30MP0000569_abnormal_digit_pigmentation1.72695050
31MP0005645_abnormal_hypothalamus_physiol1.70291953
32MP0002733_abnormal_thermal_nociception1.70182325
33MP0002909_abnormal_adrenal_gland1.70112908
34MP0002557_abnormal_social/conspecific_i1.69389362
35MP0001905_abnormal_dopamine_level1.69296581
36MP0004885_abnormal_endolymph1.67452422
37MP0003136_yellow_coat_color1.65674634
38MP0002067_abnormal_sensory_capabilities1.63411044
39MP0003011_delayed_dark_adaptation1.62087702
40MP0005253_abnormal_eye_physiology1.60280577
41MP0004133_heterotaxia1.55753208
42MP0004924_abnormal_behavior1.52582898
43MP0005386_behavior/neurological_phenoty1.52582898
44MP0010386_abnormal_urinary_bladder1.52442279
45MP0003122_maternal_imprinting1.50774290
46MP0008877_abnormal_DNA_methylation1.48789956
47MP0006072_abnormal_retinal_apoptosis1.41295398
48MP0004742_abnormal_vestibular_system1.40368534
49MP0001188_hyperpigmentation1.40215368
50MP0001986_abnormal_taste_sensitivity1.37394651
51MP0005646_abnormal_pituitary_gland1.35856725
52MP0004043_abnormal_pH_regulation1.34921754
53MP0002837_dystrophic_cardiac_calcinosis1.30979049
54MP0003195_calcinosis1.27243764
55MP0004811_abnormal_neuron_physiology1.26090412
56MP0002882_abnormal_neuron_morphology1.25238700
57MP0000955_abnormal_spinal_cord1.25011990
58MP0001502_abnormal_circadian_rhythm1.24175788
59MP0002184_abnormal_innervation1.18342792
60MP0005499_abnormal_olfactory_system1.17714090
61MP0005394_taste/olfaction_phenotype1.17714090
62MP0000631_abnormal_neuroendocrine_gland1.13467938
63MP0005167_abnormal_blood-brain_barrier1.12817127
64MP0003633_abnormal_nervous_system1.12758985
65MP0005084_abnormal_gallbladder_morpholo1.10167531
66MP0003121_genomic_imprinting1.09363765
67MP0008789_abnormal_olfactory_epithelium1.08449069
68MP0002229_neurodegeneration1.07995129
69MP0005187_abnormal_penis_morphology1.07900646
70MP0001485_abnormal_pinna_reflex1.07575684
71MP0001440_abnormal_grooming_behavior1.05633119
72MP0008875_abnormal_xenobiotic_pharmacok1.04776372
73MP0002066_abnormal_motor_capabilities/c1.04069532
74MP0008569_lethality_at_weaning1.03579710
75MP0000026_abnormal_inner_ear1.02211310
76MP0008872_abnormal_physiological_respon1.02013848
77MP0002876_abnormal_thyroid_physiology1.01804657
78MP0002752_abnormal_somatic_nervous0.98768449
79MP0004147_increased_porphyrin_level0.97962909
80MP0002928_abnormal_bile_duct0.96440618
81MP0002751_abnormal_autonomic_nervous0.94107036
82MP0001963_abnormal_hearing_physiology0.93944353
83MP0003631_nervous_system_phenotype0.89599298
84MP0002090_abnormal_vision0.89549718
85MP0008995_early_reproductive_senescence0.86794176
86MP0004215_abnormal_myocardial_fiber0.86129661
87MP0002069_abnormal_eating/drinking_beha0.85983086
88MP0003137_abnormal_impulse_conducting0.85937040
89MP0002152_abnormal_brain_morphology0.83487215
90MP0005195_abnormal_posterior_eye0.82202248
91MP0003879_abnormal_hair_cell0.81885235
92MP0000647_abnormal_sebaceous_gland0.78180944
93MP0002277_abnormal_respiratory_mucosa0.75787748
94MP0005535_abnormal_body_temperature0.73610318
95MP0005248_abnormal_Harderian_gland0.73563632
96MP0000427_abnormal_hair_cycle0.71511789
97MP0004085_abnormal_heartbeat0.70430488
98MP0005171_absent_coat_pigmentation0.68286784
99MP0002234_abnormal_pharynx_morphology0.67022232
100MP0003632_abnormal_nervous_system0.65409771

Predicted human phenotypes

RankGene SetZ-score
1Polyphagia (HP:0002591)3.65694000
2Medial flaring of the eyebrow (HP:0010747)3.62679252
3Focal motor seizures (HP:0011153)3.62293061
4Gait imbalance (HP:0002141)3.58029615
5Pancreatic cysts (HP:0001737)3.47018900
6True hermaphroditism (HP:0010459)3.41268635
7Pancreatic fibrosis (HP:0100732)3.34088936
8Febrile seizures (HP:0002373)3.32714393
9Congenital primary aphakia (HP:0007707)3.27291019
10Hyperventilation (HP:0002883)3.14427950
11Molar tooth sign on MRI (HP:0002419)3.14369698
12Abnormality of midbrain morphology (HP:0002418)3.14369698
13Progressive cerebellar ataxia (HP:0002073)3.12483819
14Limb dystonia (HP:0002451)3.11655750
15Nephrogenic diabetes insipidus (HP:0009806)3.06023235
16Hemiparesis (HP:0001269)2.94394436
17Focal seizures (HP:0007359)2.93850389
18Myokymia (HP:0002411)2.90537740
19Epileptic encephalopathy (HP:0200134)2.86865754
20Nephronophthisis (HP:0000090)2.85530894
21Atonic seizures (HP:0010819)2.85185018
22Absent speech (HP:0001344)2.72567221
23Genital tract atresia (HP:0001827)2.64104102
24Drooling (HP:0002307)2.61480038
25Broad-based gait (HP:0002136)2.60274772
26Renal cortical cysts (HP:0000803)2.60179616
27Abnormal respiratory epithelium morphology (HP:0012253)2.58222036
28Abnormal respiratory motile cilium morphology (HP:0005938)2.58222036
29Abnormal eating behavior (HP:0100738)2.56487404
30Acute necrotizing encephalopathy (HP:0006965)2.54255955
31Vaginal atresia (HP:0000148)2.51587368
32Agitation (HP:0000713)2.51018386
33Lissencephaly (HP:0001339)2.48766397
34Dialeptic seizures (HP:0011146)2.47125422
35Progressive macrocephaly (HP:0004481)2.46674230
36Abnormal ciliary motility (HP:0012262)2.45874591
37Inability to walk (HP:0002540)2.45765398
38Epileptiform EEG discharges (HP:0011182)2.42160108
39Hypsarrhythmia (HP:0002521)2.40197626
40Excessive salivation (HP:0003781)2.39959045
41Abnormality of the renal cortex (HP:0011035)2.39645970
42EEG with generalized epileptiform discharges (HP:0011198)2.39638972
43Abnormality of the renal medulla (HP:0100957)2.37586570
44Degeneration of the lateral corticospinal tracts (HP:0002314)2.37198874
45Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.37198874
46Type II lissencephaly (HP:0007260)2.35356076
47Mitochondrial inheritance (HP:0001427)2.33732267
48Specific learning disability (HP:0001328)2.33676589
49Absent/shortened dynein arms (HP:0200106)2.33654174
50Dynein arm defect of respiratory motile cilia (HP:0012255)2.33654174
51Chronic hepatic failure (HP:0100626)2.30778574
52Split foot (HP:0001839)2.27379613
53Abnormal respiratory motile cilium physiology (HP:0012261)2.25674941
54Congenital stationary night blindness (HP:0007642)2.25635802
55Abnormal mitochondria in muscle tissue (HP:0008316)2.25587084
56Pachygyria (HP:0001302)2.24764811
57Generalized tonic-clonic seizures (HP:0002069)2.21763503
58Retinal dysplasia (HP:0007973)2.17615865
593-Methylglutaconic aciduria (HP:0003535)2.16516179
60Progressive inability to walk (HP:0002505)2.15980624
61Absence seizures (HP:0002121)2.13192540
62Action tremor (HP:0002345)2.13025426
63Gaze-evoked nystagmus (HP:0000640)2.10213550
64Ankle clonus (HP:0011448)2.09594288
65Poor coordination (HP:0002370)2.07779904
66Aplasia/Hypoplasia of the tibia (HP:0005772)2.07437380
67Abolished electroretinogram (ERG) (HP:0000550)2.07043599
68Abnormality of the corticospinal tract (HP:0002492)2.06830706
69Genetic anticipation (HP:0003743)2.06732788
70Spastic tetraplegia (HP:0002510)2.06021242
71Cystic liver disease (HP:0006706)2.05326464
72Mutism (HP:0002300)2.04912908
73Increased CSF lactate (HP:0002490)2.04781094
74Failure to thrive in infancy (HP:0001531)2.02774635
75Acute encephalopathy (HP:0006846)2.01597111
76Poor suck (HP:0002033)2.00860773
77Decreased central vision (HP:0007663)1.99669191
78Hypothermia (HP:0002045)1.99036660
79Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.99034299
80Abnormality of alanine metabolism (HP:0010916)1.99034299
81Hyperalaninemia (HP:0003348)1.99034299
82Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.98807774
83Amyotrophic lateral sclerosis (HP:0007354)1.98515118
84Postaxial hand polydactyly (HP:0001162)1.96071484
85Abnormal drinking behavior (HP:0030082)1.95251404
86Polydipsia (HP:0001959)1.95251404
87Spastic gait (HP:0002064)1.95075371
88Methylmalonic acidemia (HP:0002912)1.94668908
89Short tibia (HP:0005736)1.93500063
90Attenuation of retinal blood vessels (HP:0007843)1.91195743
91Large for gestational age (HP:0001520)1.88847238
92Occipital encephalocele (HP:0002085)1.88493089
93Optic disc pallor (HP:0000543)1.87528454
94Increased hepatocellular lipid droplets (HP:0006565)1.84626067
95Rhinitis (HP:0012384)1.83644368
96Bile duct proliferation (HP:0001408)1.82706210
97Abnormal biliary tract physiology (HP:0012439)1.82706210
98Lipid accumulation in hepatocytes (HP:0006561)1.82309418
99Thyroid-stimulating hormone excess (HP:0002925)1.81728493
100Urinary urgency (HP:0000012)1.81228117

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.68939254
2MAP3K43.45847318
3CASK3.23874311
4MAP4K23.10372197
5MAP2K72.92325296
6FRK2.81063934
7WNK32.65748260
8MAPK132.47485598
9BCR2.46197951
10PINK12.37086595
11ADRBK22.26847638
12EPHA32.05549392
13TRIM282.02678970
14NTRK21.87716049
15ERBB31.87597848
16NTRK31.85528060
17DAPK21.82764571
18BMPR1B1.74828381
19EPHA41.72250858
20CSNK1G21.62394601
21PAK31.60963755
22DYRK21.60642214
23CSNK1G31.40045308
24MAP2K41.38754776
25CAMKK21.38637079
26UHMK11.36279349
27GRK11.32422938
28PLK21.31704062
29PRKCG1.28011959
30CSNK1A1L1.26915691
31MAPK151.25089022
32DYRK31.17403103
33INSRR1.15075605
34PAK61.14517001
35CSNK1G11.13789594
36PRKCE1.12515989
37BCKDK1.12085402
38MINK11.09338040
39SIK20.99777383
40CAMK2A0.96121313
41WNK40.91058620
42PKN10.88423686
43DYRK1B0.87021292
44CDK50.86529799
45LIMK10.86394297
46TNIK0.84827562
47SGK4940.84521580
48SGK2230.84521580
49PHKG10.84158001
50PHKG20.84158001
51TAOK30.83549048
52OXSR10.79586029
53CAMK2B0.79098371
54DYRK1A0.78903705
55CDK190.74742118
56ACVR1B0.69510589
57SGK20.67211553
58ADRBK10.64777784
59MAP3K120.63423467
60ZAK0.63095680
61GRK50.59226540
62MAPKAPK50.58293346
63PRKACA0.57995102
64CAMKK10.56648739
65TLK10.56249218
66MST40.55142084
67STK38L0.55120595
68MUSK0.54662969
69PRKCZ0.54553668
70FER0.54306469
71AKT30.51701584
72CAMK2D0.51385304
73CCNB10.50699542
74STK390.50481270
75MAP3K50.50380358
76CAMK2G0.49978308
77TESK10.48555790
78CAMK40.48516583
79RPS6KA40.48507829
80CDK140.48405213
81EPHB20.46709449
82FGFR20.46096127
83PRKG10.45913691
84PNCK0.45745049
85KSR10.43296727
86CAMK10.39573177
87CSNK1A10.39319338
88GRK70.39271953
89SIK30.37723196
90PRKACB0.37573727
91CSNK1D0.37376548
92TNK20.37255899
93RPS6KA50.36134331
94TXK0.36106181
95PRKCA0.35754859
96CDK180.35403187
97NUAK10.34605804
98PRKACG0.32633072
99MAP3K60.31920108
100STK110.31852104

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.88715143
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.93467841
3Oxidative phosphorylation_Homo sapiens_hsa001902.84325202
4GABAergic synapse_Homo sapiens_hsa047272.71009954
5Collecting duct acid secretion_Homo sapiens_hsa049662.55617165
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.44153516
7Synaptic vesicle cycle_Homo sapiens_hsa047212.40358818
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.38848785
9Morphine addiction_Homo sapiens_hsa050322.35730968
10Protein export_Homo sapiens_hsa030602.31937936
11Phototransduction_Homo sapiens_hsa047442.20626023
12Parkinsons disease_Homo sapiens_hsa050122.15407681
13Butanoate metabolism_Homo sapiens_hsa006502.11935163
14Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.02446838
15Glutamatergic synapse_Homo sapiens_hsa047242.01308897
16Circadian entrainment_Homo sapiens_hsa047131.99915155
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.98348199
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.74877556
19Dopaminergic synapse_Homo sapiens_hsa047281.73330885
20Taste transduction_Homo sapiens_hsa047421.72446076
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.68037056
22Cocaine addiction_Homo sapiens_hsa050301.59701344
23Regulation of autophagy_Homo sapiens_hsa041401.52624697
24Alzheimers disease_Homo sapiens_hsa050101.51533742
25Amphetamine addiction_Homo sapiens_hsa050311.49822344
26Cardiac muscle contraction_Homo sapiens_hsa042601.49085394
27Serotonergic synapse_Homo sapiens_hsa047261.43483020
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42359637
29Nitrogen metabolism_Homo sapiens_hsa009101.40448849
30Primary bile acid biosynthesis_Homo sapiens_hsa001201.37554744
31Insulin secretion_Homo sapiens_hsa049111.35730994
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.34433158
33Linoleic acid metabolism_Homo sapiens_hsa005911.33622175
34Huntingtons disease_Homo sapiens_hsa050161.29152920
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.25750208
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.24430104
37Peroxisome_Homo sapiens_hsa041461.21195987
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.20675217
39Circadian rhythm_Homo sapiens_hsa047101.13428841
40Maturity onset diabetes of the young_Homo sapiens_hsa049501.08699345
41Ether lipid metabolism_Homo sapiens_hsa005651.08020898
42Olfactory transduction_Homo sapiens_hsa047401.04769674
43Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.04208700
44Steroid biosynthesis_Homo sapiens_hsa001001.04207086
45Long-term depression_Homo sapiens_hsa047301.02409462
46beta-Alanine metabolism_Homo sapiens_hsa004101.01895712
47Cholinergic synapse_Homo sapiens_hsa047251.01356520
48Propanoate metabolism_Homo sapiens_hsa006400.97630062
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.95603349
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.90186145
51Tryptophan metabolism_Homo sapiens_hsa003800.86174859
52Caffeine metabolism_Homo sapiens_hsa002320.83484979
53Vibrio cholerae infection_Homo sapiens_hsa051100.83315239
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82436249
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82269311
56Renin secretion_Homo sapiens_hsa049240.80396040
57Salivary secretion_Homo sapiens_hsa049700.80293202
58Chemical carcinogenesis_Homo sapiens_hsa052040.72715018
59Fatty acid elongation_Homo sapiens_hsa000620.72056001
60Gastric acid secretion_Homo sapiens_hsa049710.69386176
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.68730212
62Axon guidance_Homo sapiens_hsa043600.68273774
63Calcium signaling pathway_Homo sapiens_hsa040200.66467906
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65729868
65cAMP signaling pathway_Homo sapiens_hsa040240.64629794
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.63055165
67ABC transporters_Homo sapiens_hsa020100.62770752
68Basal transcription factors_Homo sapiens_hsa030220.59520494
69Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59455467
70Aldosterone synthesis and secretion_Homo sapiens_hsa049250.58159956
71Rheumatoid arthritis_Homo sapiens_hsa053230.55998458
72Oxytocin signaling pathway_Homo sapiens_hsa049210.54253015
73Histidine metabolism_Homo sapiens_hsa003400.53624827
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51829173
75Retinol metabolism_Homo sapiens_hsa008300.50462788
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.49903877
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46969541
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45568648
79Arachidonic acid metabolism_Homo sapiens_hsa005900.43787265
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43648038
81Phagosome_Homo sapiens_hsa041450.43000895
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.41932250
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41537456
84Metabolic pathways_Homo sapiens_hsa011000.40290059
85Folate biosynthesis_Homo sapiens_hsa007900.39376480
86Sulfur metabolism_Homo sapiens_hsa009200.38316827
87Ovarian steroidogenesis_Homo sapiens_hsa049130.37835153
88Type II diabetes mellitus_Homo sapiens_hsa049300.37663663
89Alcoholism_Homo sapiens_hsa050340.37032636
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36214394
91Gap junction_Homo sapiens_hsa045400.33315786
92Ras signaling pathway_Homo sapiens_hsa040140.32354040
93Long-term potentiation_Homo sapiens_hsa047200.30221432
94Fatty acid metabolism_Homo sapiens_hsa012120.28639397
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28500143
96Mineral absorption_Homo sapiens_hsa049780.27477311
97RNA polymerase_Homo sapiens_hsa030200.27384238
98Pancreatic secretion_Homo sapiens_hsa049720.26535298
99Glycerolipid metabolism_Homo sapiens_hsa005610.25765190
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.22147584

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