C17ORF98

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)9.68809070
2chromosome condensation (GO:0030261)9.58976413
3DNA packaging (GO:0006323)9.09283081
4spermatid nucleus differentiation (GO:0007289)8.51736673
5sperm capacitation (GO:0048240)8.46435722
6plasma membrane fusion (GO:0045026)8.30960620
7single strand break repair (GO:0000012)8.17678746
8microtubule depolymerization (GO:0007019)8.14835111
9spermatid development (GO:0007286)8.05911362
10sperm-egg recognition (GO:0035036)7.81677322
11multicellular organism reproduction (GO:0032504)7.65415174
12binding of sperm to zona pellucida (GO:0007339)7.27970959
13reproduction (GO:0000003)7.16013651
14rRNA methylation (GO:0031167)7.13451932
15microtubule polymerization or depolymerization (GO:0031109)6.88085473
16sexual reproduction (GO:0019953)6.81490751
17protein polyglutamylation (GO:0018095)6.79816669
18calcium ion-dependent exocytosis (GO:0017156)6.63103211
19cell-cell recognition (GO:0009988)6.44075188
20spermatogenesis (GO:0007283)6.24421252
21rRNA modification (GO:0000154)6.24286744
22male gamete generation (GO:0048232)6.22419837
23protein targeting to Golgi (GO:0000042)6.13046449
24axonemal dynein complex assembly (GO:0070286)6.01731531
25cellular ketone body metabolic process (GO:0046950)5.98676450
26negative regulation of inclusion body assembly (GO:0090084)5.92386444
27establishment of protein localization to Golgi (GO:0072600)5.91848014
28phosphatidylethanolamine biosynthetic process (GO:0006646)5.72937456
29gamete generation (GO:0007276)5.71050064
30retrograde transport, vesicle recycling within Golgi (GO:0000301)5.68199787
31centriole replication (GO:0007099)5.68060331
32microtubule severing (GO:0051013)5.48315051
33antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.29379825
34phosphatidylethanolamine metabolic process (GO:0046337)5.27490263
35ketone body metabolic process (GO:1902224)5.26348086
36single fertilization (GO:0007338)5.18188191
37chromatin silencing (GO:0006342)5.00860396
38cell wall macromolecule catabolic process (GO:0016998)4.98865647
39regulation of Rab GTPase activity (GO:0032313)4.92372879
40positive regulation of Rab GTPase activity (GO:0032851)4.92372879
41cell wall macromolecule metabolic process (GO:0044036)4.87697024
42regulation of cilium movement (GO:0003352)4.78157646
43centriole assembly (GO:0098534)4.73969837
44germ cell development (GO:0007281)4.62400470
45multicellular organismal reproductive process (GO:0048609)4.54697105
46protein localization to Golgi apparatus (GO:0034067)4.53962402
47motile cilium assembly (GO:0044458)4.47940887
48regulation of inclusion body assembly (GO:0090083)4.46233806
49regulation of centriole replication (GO:0046599)4.42834742
50cilium or flagellum-dependent cell motility (GO:0001539)4.33356522
51RNA destabilization (GO:0050779)4.32985754
52cellular process involved in reproduction in multicellular organism (GO:0022412)4.32651680
53fertilization (GO:0009566)4.29818330
54seminiferous tubule development (GO:0072520)4.16594631
55glomerular visceral epithelial cell development (GO:0072015)4.11747266
56regulation of transcription involved in cell fate commitment (GO:0060850)4.11131322
57epithelial cilium movement (GO:0003351)4.09443705
58nucleus organization (GO:0006997)4.07908557
59coenzyme catabolic process (GO:0009109)4.07594085
60glomerular epithelial cell development (GO:0072310)3.87776511
61glycerol ether metabolic process (GO:0006662)3.86133737
62histone H3-K9 demethylation (GO:0033169)3.61911550
63ether metabolic process (GO:0018904)3.54705106
64response to acidic pH (GO:0010447)3.54251139
65cilium movement (GO:0003341)3.48427603
66negative regulation of gene expression, epigenetic (GO:0045814)3.47587758
67male meiosis I (GO:0007141)3.45899282
68negative regulation of Rho protein signal transduction (GO:0035024)3.45885069
69cellular response to pH (GO:0071467)3.41603055
70multicellular organismal movement (GO:0050879)3.36592941
71musculoskeletal movement (GO:0050881)3.36592941
72organic cation transport (GO:0015695)3.19100046
73male meiosis (GO:0007140)3.10417290
74microtubule nucleation (GO:0007020)3.08538789
75cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.07103668
76polyamine biosynthetic process (GO:0006596)3.05782379
77detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.01761525
78cell recognition (GO:0008037)3.00464230
79multicellular organismal development (GO:0007275)2.99899138
80regulation of microtubule-based movement (GO:0060632)2.95911167
81DNA conformation change (GO:0071103)2.95513770
82epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.93912879
83cerebral cortex neuron differentiation (GO:0021895)2.92770795
84receptor recycling (GO:0001881)2.92622183
85NAD biosynthetic process (GO:0009435)2.92303834
86protein-DNA complex disassembly (GO:0032986)2.87342822
87nucleosome disassembly (GO:0006337)2.87342822
88peptidyl-proline hydroxylation (GO:0019511)2.85137003
89membrane protein intracellular domain proteolysis (GO:0031293)2.84061626
90protein depolymerization (GO:0051261)2.84000812
91piRNA metabolic process (GO:0034587)2.82555841
92histone exchange (GO:0043486)2.76596369
93regulation of interleukin-13 production (GO:0032656)2.75172812
94regulation of T-helper 2 cell differentiation (GO:0045628)2.74787796
95mesenchymal cell differentiation involved in kidney development (GO:0072161)2.74310200
96mesenchymal cell differentiation involved in renal system development (GO:2001012)2.74310200
97cell differentiation involved in metanephros development (GO:0072202)2.72905483
98acrosome reaction (GO:0007340)12.2382357
99sperm motility (GO:0030317)11.2645639
100fusion of sperm to egg plasma membrane (GO:0007342)10.9796338

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.83906588
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.55074274
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.42531490
4CTBP2_25329375_ChIP-Seq_LNCAP_Human2.42568808
5IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.28768538
6CBP_20019798_ChIP-Seq_JUKART_Human2.28768538
7POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.23959903
8TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.23959903
9EZH2_22144423_ChIP-Seq_EOC_Human2.16374617
10ERA_21632823_ChIP-Seq_H3396_Human2.15519335
11CTBP1_25329375_ChIP-Seq_LNCAP_Human2.08291366
12VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.06524942
13FUS_26573619_Chip-Seq_HEK293_Human2.00868821
14EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.00334866
15UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.94318088
16ELF1_20517297_ChIP-Seq_JURKAT_Human1.93685519
17ZNF274_21170338_ChIP-Seq_K562_Hela1.93150281
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.92627839
19EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.90593387
20EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.90088286
21NANOG_20526341_ChIP-Seq_ESCs_Human1.85296069
22RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.83786187
23* RAC3_21632823_ChIP-Seq_H3396_Human1.81267169
24ER_23166858_ChIP-Seq_MCF-7_Human1.79597668
25MYC_19829295_ChIP-Seq_ESCs_Human1.76106002
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75089937
27WDR5_24793694_ChIP-Seq_LNCAP_Human1.67444476
28SMAD4_21741376_ChIP-Seq_EPCs_Human1.67240655
29TAF2_19829295_ChIP-Seq_ESCs_Human1.66871541
30BCL6_27268052_Chip-Seq_Bcells_Human1.63534459
31E2F1_20622854_ChIP-Seq_HELA_Human1.63347408
32SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.59552911
33AR_25329375_ChIP-Seq_VCAP_Human1.56080468
34CTCF_27219007_Chip-Seq_Bcells_Human1.55677171
35ARNT_22903824_ChIP-Seq_MCF-7_Human1.54849043
36ETV2_25802403_ChIP-Seq_MESCs_Mouse1.54600789
37AUTS2_25519132_ChIP-Seq_293T-REX_Human1.53820089
38TDRD3_21172665_ChIP-Seq_MCF-7_Human1.53262888
39PHF8_20622854_ChIP-Seq_HELA_Human1.50522421
40OCT4_20526341_ChIP-Seq_ESCs_Human1.50496994
41RBPJ_21746931_ChIP-Seq_IB4_Human1.50309844
42YY1_22570637_ChIP-Seq_MALME-3M_Human1.50202014
43DROSHA_22980978_ChIP-Seq_HELA_Human1.50174635
44BCOR_27268052_Chip-Seq_Bcells_Human1.49577190
45HNFA_21074721_ChIP-Seq_CACO-2_Human1.46993784
46CTCF_20526341_ChIP-Seq_ESCs_Human1.46208521
47GATA3_21878914_ChIP-Seq_MCF-7_Human1.45018324
48P300_19829295_ChIP-Seq_ESCs_Human1.44258938
49CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.42777431
50P300_27268052_Chip-Seq_Bcells_Human1.41565433
51ETV1_20927104_ChIP-Seq_GIST48_Human1.41221865
52SMC4_20622854_ChIP-Seq_HELA_Human1.41081728
53STAT6_21828071_ChIP-Seq_BEAS2B_Human1.40873979
54CBX2_22325352_ChIP-Seq_293T-Rex_Human1.40511726
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.38167100
56NFYB_21822215_ChIP-Seq_K562_Human1.36829734
57VDR_22108803_ChIP-Seq_LS180_Human1.35562383
58PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.35226797
59KLF5_20875108_ChIP-Seq_MESCs_Mouse1.34337745
60CEBPB_22108803_ChIP-Seq_LS180_Human1.33345270
61P68_20966046_ChIP-Seq_HELA_Human1.33197026
62P53_21459846_ChIP-Seq_SAOS-2_Human1.32700770
63ERG_20517297_ChIP-Seq_VCAP_Human1.31663342
64TBL1_22424771_ChIP-Seq_293T_Human1.31492755
65* TP63_22573176_ChIP-Seq_HFKS_Human1.31359428
66HOXB7_26014856_ChIP-Seq_BT474_Human1.29542207
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29115990
68PHF8_20622853_ChIP-Seq_HELA_Human1.28555199
69SMAD3_21741376_ChIP-Seq_ESCs_Human1.25139148
70EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.24924312
71ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24750044
72NANOG_19829295_ChIP-Seq_ESCs_Human1.24023814
73SOX2_19829295_ChIP-Seq_ESCs_Human1.24023814
74TP53_18474530_ChIP-ChIP_U2OS_Human1.21984341
75SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.21329567
76SMAD4_21741376_ChIP-Seq_HESCs_Human1.20860573
77PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.20311425
78SMRT_27268052_Chip-Seq_Bcells_Human1.18704938
79GATA6_21074721_ChIP-Seq_CACO-2_Human1.16679931
80TAF15_26573619_Chip-Seq_HEK293_Human1.16131238
81RUNX2_22187159_ChIP-Seq_PCA_Human1.15416473
82GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15045042
83PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11134761
84* P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.09317067
85SOX2_22085726_ChIP-Seq_NPCs_Mouse1.08115209
86SA1_27219007_Chip-Seq_Bcells_Human1.08005301
87NFYA_21822215_ChIP-Seq_K562_Human1.07232276
88TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.06977119
89KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.06670011
90STAT3_23295773_ChIP-Seq_U87_Human1.06506839
91GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.05960647
92PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.05955288
93SALL1_21062744_ChIP-ChIP_HESCs_Human1.05675894
94SUZ12_27294783_Chip-Seq_ESCs_Mouse1.04915755
95FOXH1_21741376_ChIP-Seq_EPCs_Human1.04665533
96SMAD4_21799915_ChIP-Seq_A2780_Human1.04056523
97TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02614873
98AR_21572438_ChIP-Seq_LNCaP_Human1.01455135
99TP63_19390658_ChIP-ChIP_HaCaT_Human0.99936155
100SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99899829

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot5.06011138
2MP0003878_abnormal_ear_physiology5.06011138
3MP0003698_abnormal_male_reproductive4.27195246
4MP0001929_abnormal_gametogenesis3.86930600
5MP0005670_abnormal_white_adipose3.80473580
6MP0001348_abnormal_lacrimal_gland3.57564590
7MP0003718_maternal_effect2.53912487
8MP0003011_delayed_dark_adaptation2.46159191
9MP0005379_endocrine/exocrine_gland_phen2.39936288
10MP0000678_abnormal_parathyroid_gland2.39026832
11MP0002161_abnormal_fertility/fecundity2.36780109
12MP0002132_abnormal_respiratory_system2.15874813
13MP0005423_abnormal_somatic_nervous2.10406334
14MP0005410_abnormal_fertilization11.7191425
15MP0002210_abnormal_sex_determination1.90826522
16MP0002234_abnormal_pharynx_morphology1.79898765
17MP0002282_abnormal_trachea_morphology1.76560285
18MP0002249_abnormal_larynx_morphology1.70252334
19MP0003646_muscle_fatigue1.69695062
20MP0008877_abnormal_DNA_methylation1.67517809
21MP0001968_abnormal_touch/_nociception1.64024375
22MP0001485_abnormal_pinna_reflex1.60748853
23MP0001486_abnormal_startle_reflex1.50580923
24MP0001145_abnormal_male_reproductive1.46802762
25MP0000653_abnormal_sex_gland1.43426626
26MP0002735_abnormal_chemical_nociception1.41675266
27MP0009053_abnormal_anal_canal1.36055338
28MP0006292_abnormal_olfactory_placode1.32262817
29MP0004742_abnormal_vestibular_system1.31997553
30MP0003879_abnormal_hair_cell1.23065448
31MP0005395_other_phenotype1.19499446
32MP0005310_abnormal_salivary_gland1.16757011
33MP0001765_abnormal_ion_homeostasis1.15954628
34MP0000049_abnormal_middle_ear1.11436769
35MP0002822_catalepsy1.09780877
36MP0001963_abnormal_hearing_physiology1.08657752
37MP0005551_abnormal_eye_electrophysiolog1.06433473
38MP0009697_abnormal_copulation1.06121737
39MP0002138_abnormal_hepatobiliary_system1.02137777
40MP0000534_abnormal_ureter_morphology1.00818683
41MP0006276_abnormal_autonomic_nervous1.00457027
42MP0000681_abnormal_thyroid_gland0.97994638
43MP0000026_abnormal_inner_ear0.96868925
44MP0002127_abnormal_cardiovascular_syste0.90982836
45MP0002733_abnormal_thermal_nociception0.87454309
46MP0004510_myositis0.87442586
47MP0002229_neurodegeneration0.87280478
48MP0003950_abnormal_plasma_membrane0.87027680
49MP0004859_abnormal_synaptic_plasticity0.84280155
50MP0004270_analgesia0.81827132
51MP0009745_abnormal_behavioral_response0.75065221
52MP0002067_abnormal_sensory_capabilities0.72508819
53MP0001970_abnormal_pain_threshold0.71882505
54MP0002557_abnormal_social/conspecific_i0.70943393
55MP0001984_abnormal_olfaction0.68869821
56MP0000372_irregular_coat_pigmentation0.68866039
57MP0005248_abnormal_Harderian_gland0.68195316
58MP0005636_abnormal_mineral_homeostasis0.68085739
59MP0003077_abnormal_cell_cycle0.67901887
60MP0005084_abnormal_gallbladder_morpholo0.65592593
61MP0002254_reproductive_system_inflammat0.64916633
62MP0001501_abnormal_sleep_pattern0.64521383
63MP0004085_abnormal_heartbeat0.64489427
64MP0002928_abnormal_bile_duct0.62618775
65MP0005451_abnormal_body_composition0.61863110
66MP0001293_anophthalmia0.59808044
67MP0000955_abnormal_spinal_cord0.59182761
68MP0003880_abnormal_central_pattern0.58119041
69MP0002734_abnormal_mechanical_nocicepti0.58020483
70MP0009115_abnormal_fat_cell0.57937719
71MP0008569_lethality_at_weaning0.56243069
72MP0003936_abnormal_reproductive_system0.55854790
73MP0002163_abnormal_gland_morphology0.54699479
74MP0001905_abnormal_dopamine_level0.54277656
75MP0002572_abnormal_emotion/affect_behav0.54043444
76MP0010386_abnormal_urinary_bladder0.53975678
77MP0005253_abnormal_eye_physiology0.53593432
78MP0002272_abnormal_nervous_system0.53286470
79MP0000230_abnormal_systemic_arterial0.52353606
80MP0008789_abnormal_olfactory_epithelium0.51325063
81MP0001440_abnormal_grooming_behavior0.50438592
82MP0000516_abnormal_urinary_system0.50047163
83MP0005367_renal/urinary_system_phenotyp0.50047163
84MP0001270_distended_abdomen0.49290568
85MP0000470_abnormal_stomach_morphology0.48414581
86MP0005332_abnormal_amino_acid0.45226752
87MP0002653_abnormal_ependyma_morphology0.44555463
88MP0003137_abnormal_impulse_conducting0.43845690
89MP0001666_abnormal_nutrient_absorption0.43391701
90MP0003699_abnormal_female_reproductive0.43099945
91MP0001879_abnormal_lymphatic_vessel0.40458279
92MP0008995_early_reproductive_senescence0.40209801
93MP0005535_abnormal_body_temperature0.37999536
94MP0000467_abnormal_esophagus_morphology0.37551618
95MP0003119_abnormal_digestive_system0.35130728
96MP0003938_abnormal_ear_development0.34603144
97MP0002168_other_aberrant_phenotype0.34467183
98MP0005391_vision/eye_phenotype0.34244383
99MP0003136_yellow_coat_color0.33947157
100MP0010329_abnormal_lipoprotein_level0.33879449

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)9.12805354
2Dynein arm defect of respiratory motile cilia (HP:0012255)5.82641667
3Absent/shortened dynein arms (HP:0200106)5.82641667
4Attenuation of retinal blood vessels (HP:0007843)5.17989397
5Bony spicule pigmentary retinopathy (HP:0007737)5.14869522
6Asymmetric septal hypertrophy (HP:0001670)4.58525395
7Abnormal respiratory motile cilium physiology (HP:0012261)4.35835680
8Abnormal ciliary motility (HP:0012262)4.34285085
9Chronic hepatic failure (HP:0100626)4.33916266
10Tubulointerstitial nephritis (HP:0001970)4.33292029
11Abnormal rod and cone electroretinograms (HP:0008323)4.29353974
12Abnormal respiratory epithelium morphology (HP:0012253)4.17968190
13Abnormal respiratory motile cilium morphology (HP:0005938)4.17968190
14Abnormality of macular pigmentation (HP:0008002)3.97525665
15Infertility (HP:0000789)3.92013595
16Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.76930290
17Aplasia/Hypoplasia of the earlobes (HP:0009906)3.76805807
18Resting tremor (HP:0002322)3.69795368
19Bell-shaped thorax (HP:0001591)3.68661944
20Male infertility (HP:0003251)3.68275825
21Cone-rod dystrophy (HP:0000548)3.66423061
22Azoospermia (HP:0000027)3.61651118
23Hyperkalemia (HP:0002153)3.58288490
24Facial shape deformation (HP:0011334)3.57644308
25Potter facies (HP:0002009)3.57644308
26Enlarged epiphyses (HP:0010580)3.54666766
27Nasal polyposis (HP:0100582)3.50932875
28Abnormal spermatogenesis (HP:0008669)3.43710065
29Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.35077754
30Abnormality of dental color (HP:0011073)3.30085871
31Hypoplastic ischia (HP:0003175)3.20733170
32Hypoplasia of the thymus (HP:0000778)3.02213857
33Impulsivity (HP:0100710)2.94199296
34Progressive sensorineural hearing impairment (HP:0000408)2.93245056
35Abnormality of the ischium (HP:0003174)2.76951653
36Amelogenesis imperfecta (HP:0000705)2.74854063
37Rhinitis (HP:0012384)2.73681291
38Abnormal urine output (HP:0012590)2.73466438
39Abnormality of the nasal mucosa (HP:0000433)2.70176570
40Recurrent corneal erosions (HP:0000495)2.68102721
41Abnormality of the aortic arch (HP:0012303)2.64704809
42Nephronophthisis (HP:0000090)2.63877942
43Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.60963740
44Abnormal drinking behavior (HP:0030082)2.57906667
45Polydipsia (HP:0001959)2.57906667
46Insulin-resistant diabetes mellitus (HP:0000831)2.48645408
47Stage 5 chronic kidney disease (HP:0003774)2.48621915
48Renal dysplasia (HP:0000110)2.48401919
49Hypophosphatemic rickets (HP:0004912)2.47155355
50Hyperthyroidism (HP:0000836)2.46905507
51Congenital malformation of the right heart (HP:0011723)2.41531229
52Double outlet right ventricle (HP:0001719)2.41531229
53Unilateral renal agenesis (HP:0000122)2.39092303
54Abnormal albumin level (HP:0012116)2.36835738
55Hypoalbuminemia (HP:0003073)2.36835738
56Abnormality of the renal medulla (HP:0100957)2.35258412
57Generalized aminoaciduria (HP:0002909)2.34737825
58Abnormality of renal excretion (HP:0011036)2.33388076
59Polyuria (HP:0000103)2.32595915
60Abnormality of potassium homeostasis (HP:0011042)2.28273920
61Portal hypertension (HP:0001409)2.27643549
62Abnormality of the parathyroid morphology (HP:0011766)2.27209326
63Sensory axonal neuropathy (HP:0003390)2.27108889
64Hypoparathyroidism (HP:0000829)2.26696409
65Progressive cerebellar ataxia (HP:0002073)2.25389870
66Renal Fanconi syndrome (HP:0001994)2.20403710
67Tetany (HP:0001281)2.19183894
68Hypoalphalipoproteinemia (HP:0003233)2.17039423
69Renovascular hypertension (HP:0100817)2.15364725
70Tubulointerstitial abnormality (HP:0001969)2.15201992
71Spastic paraparesis (HP:0002313)2.12661179
72Pancreatic fibrosis (HP:0100732)2.12073092
73Abnormality of the costochondral junction (HP:0000919)2.11228722
74Postural instability (HP:0002172)2.10527553
75Abnormality of the epiphysis of the femoral head (HP:0010574)2.08835983
76Abnormality of the hepatic vasculature (HP:0006707)2.06165874
77Absent epiphyses (HP:0010577)2.05727327
78Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.05727327
79Bronchiectasis (HP:0002110)2.04554665
80Truncal obesity (HP:0001956)2.04479580
81Optic nerve hypoplasia (HP:0000609)2.02734161
82Muscle fiber atrophy (HP:0100295)2.02492055
83Aplasia/Hypoplasia of the sacrum (HP:0008517)2.02086942
84Median cleft lip (HP:0000161)2.01628763
85Flat capital femoral epiphysis (HP:0003370)1.99028005
86Hyponatremia (HP:0002902)1.98779964
87Abnormality of the femoral head (HP:0003368)1.97367676
88Horizontal nystagmus (HP:0000666)1.96999772
89Pendular nystagmus (HP:0012043)1.95312679
90Chronic bronchitis (HP:0004469)1.93458934
91Scotoma (HP:0000575)1.93300864
92Flattened epiphyses (HP:0003071)1.93005726
93Tubular atrophy (HP:0000092)1.92834282
94Osteomalacia (HP:0002749)1.91841249
95Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.89743086
96Abnormality of femoral epiphyses (HP:0006499)1.89743086
97Decreased central vision (HP:0007663)1.87436761
98Congenital sensorineural hearing impairment (HP:0008527)1.87349170
99Photophobia (HP:0000613)1.87146140
100Cerebellar dysplasia (HP:0007033)1.84679655

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK48.27745143
2TESK14.72585441
3MAP4K24.52850489
4DDR24.03916992
5INSRR3.84892323
6PLK23.41475912
7PNCK3.21598198
8TRIM282.85319960
9STK382.52162605
10BRD42.28254402
11WNK12.07122288
12MAPK152.00283564
13PRKD31.98376837
14STK38L1.97643575
15CAMK1G1.92181367
16STK391.91687965
17PIK3CG1.85584409
18WNK41.81021435
19MAP3K91.65462201
20BRSK21.54628109
21CDK121.53309480
22BMPR1B1.50895443
23MST1R1.41062168
24CDK71.33206995
25OXSR11.25700074
26MUSK1.21102126
27PDPK11.21086904
28PDK11.20202393
29NEK61.12906906
30BRSK11.03910742
31DYRK1B0.97960632
32MAP3K110.91942746
33LATS20.91405673
34MATK0.91340440
35PTK2B0.85334722
36FRK0.84112346
37BRAF0.83416456
38AKT30.79328944
39PRKAA20.75773874
40ARAF0.74816823
41KSR20.70111080
42TNIK0.56904870
43MAP3K10.54828521
44ROCK10.54665427
45TAF10.52055815
46PRKG10.50456893
47PKN10.47564144
48CDK30.46227677
49PRKG20.43335886
50SIK20.43001594
51RPS6KA10.42738430
52CAMK10.42141190
53MAP3K80.41084673
54TLK10.38852184
55TYRO30.38585612
56CDK10.37066990
57GSK3B0.36808697
58MET0.36550316
59PASK0.36435759
60PRKCG0.35486516
61MAP3K130.35281981
62CDK20.34921594
63MAPK10.32098814
64MAP3K20.29647197
65UHMK10.29634461
66CHEK10.28575206
67PINK10.28527330
68CAMK1D0.28253970
69NTRK10.28046159
70AURKA0.23730142
71MTOR0.23542395
72KIT0.20414700
73PRKCZ0.20300749
74IKBKB0.20106470
75PRKCQ0.19671955
76MAPK140.19643890
77PLK10.17884386
78JAK30.16869512
79PRKCE0.16575476
80MAPK80.16176949
81SGK10.15426023
82ADRBK20.14669391
83CDK40.14421951
84TIE10.13944468
85PRKCB0.13891819
86AKT10.13757100
87FER0.13351870
88RPS6KA20.12930984
89PRKAA10.11718205
90TESK20.10516162
91MKNK20.09934470
92DYRK20.09809153
93MST40.09116658
94MARK10.08974847
95PRKACA0.08909095
96MAP3K100.08839310
97PRKACB0.08569246
98CDK190.08247083
99IGF1R0.07114693
100CAMKK20.07011059

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000728.82971587
2Fatty acid biosynthesis_Homo sapiens_hsa000614.83557305
3Olfactory transduction_Homo sapiens_hsa047404.02965009
4Butanoate metabolism_Homo sapiens_hsa006502.95615677
5Type I diabetes mellitus_Homo sapiens_hsa049402.18718676
6Allograft rejection_Homo sapiens_hsa053302.11909750
7Graft-versus-host disease_Homo sapiens_hsa053322.08695571
8Autoimmune thyroid disease_Homo sapiens_hsa053202.00104065
9Glycerophospholipid metabolism_Homo sapiens_hsa005641.81997797
10Antigen processing and presentation_Homo sapiens_hsa046121.79999575
11RNA transport_Homo sapiens_hsa030131.77384662
12Taste transduction_Homo sapiens_hsa047421.77203797
13Dorso-ventral axis formation_Homo sapiens_hsa043201.74158537
14Arginine and proline metabolism_Homo sapiens_hsa003301.46417560
15Phenylalanine metabolism_Homo sapiens_hsa003601.39336570
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.39246511
17Fatty acid metabolism_Homo sapiens_hsa012121.37754775
18Fatty acid degradation_Homo sapiens_hsa000711.26815289
19Selenocompound metabolism_Homo sapiens_hsa004501.26354521
20Basal transcription factors_Homo sapiens_hsa030221.25682130
21Salivary secretion_Homo sapiens_hsa049701.24730029
22Type II diabetes mellitus_Homo sapiens_hsa049301.24618488
23Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.21060121
24Phototransduction_Homo sapiens_hsa047441.19380732
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.16771646
26Cardiac muscle contraction_Homo sapiens_hsa042601.15367629
27Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.13805664
28Viral myocarditis_Homo sapiens_hsa054161.13275062
29Hedgehog signaling pathway_Homo sapiens_hsa043401.11699008
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11159352
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.09233440
32Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.04768840
33Endocytosis_Homo sapiens_hsa041441.02461512
34Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.02340182
35Fanconi anemia pathway_Homo sapiens_hsa034600.99981928
36Primary bile acid biosynthesis_Homo sapiens_hsa001200.96334558
37Oocyte meiosis_Homo sapiens_hsa041140.90635420
38Fat digestion and absorption_Homo sapiens_hsa049750.90417354
39Tyrosine metabolism_Homo sapiens_hsa003500.90329770
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.88564489
41Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86690072
42Protein digestion and absorption_Homo sapiens_hsa049740.86114587
43Retinol metabolism_Homo sapiens_hsa008300.85724484
44mRNA surveillance pathway_Homo sapiens_hsa030150.84262448
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.83846921
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.83006023
47cAMP signaling pathway_Homo sapiens_hsa040240.81911409
48Purine metabolism_Homo sapiens_hsa002300.79711409
49Influenza A_Homo sapiens_hsa051640.78640417
50Vitamin B6 metabolism_Homo sapiens_hsa007500.73772715
51Calcium signaling pathway_Homo sapiens_hsa040200.70457719
52Nicotine addiction_Homo sapiens_hsa050330.69252387
53Tryptophan metabolism_Homo sapiens_hsa003800.67144310
54Inositol phosphate metabolism_Homo sapiens_hsa005620.64172599
55Insulin secretion_Homo sapiens_hsa049110.63979442
56Adipocytokine signaling pathway_Homo sapiens_hsa049200.63171196
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56820963
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56092136
59Morphine addiction_Homo sapiens_hsa050320.53534072
60ABC transporters_Homo sapiens_hsa020100.50133662
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49591469
62Glycerolipid metabolism_Homo sapiens_hsa005610.49275141
63Circadian entrainment_Homo sapiens_hsa047130.48461756
64Synaptic vesicle cycle_Homo sapiens_hsa047210.47084288
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45802124
66PPAR signaling pathway_Homo sapiens_hsa033200.44615341
67Renin-angiotensin system_Homo sapiens_hsa046140.44463329
68Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42678669
69Glutamatergic synapse_Homo sapiens_hsa047240.40385324
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.38510032
71Legionellosis_Homo sapiens_hsa051340.36863720
72Chemical carcinogenesis_Homo sapiens_hsa052040.36171072
73Huntingtons disease_Homo sapiens_hsa050160.35923181
74Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.35748485
75Renin secretion_Homo sapiens_hsa049240.33941741
76Circadian rhythm_Homo sapiens_hsa047100.33744208
77Nitrogen metabolism_Homo sapiens_hsa009100.33337488
78Metabolic pathways_Homo sapiens_hsa011000.31197674
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.29845488
80Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.29614035
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.29564463
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29301630
83Bile secretion_Homo sapiens_hsa049760.28815264
84Arginine biosynthesis_Homo sapiens_hsa002200.27518201
85Propanoate metabolism_Homo sapiens_hsa006400.27428981
86Primary immunodeficiency_Homo sapiens_hsa053400.25532971
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.25008007
88Gastric acid secretion_Homo sapiens_hsa049710.24677128
89Homologous recombination_Homo sapiens_hsa034400.24054805
90Linoleic acid metabolism_Homo sapiens_hsa005910.23057453
91Pancreatic secretion_Homo sapiens_hsa049720.23049792
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.22978878
93Peroxisome_Homo sapiens_hsa041460.22349865
94Pyrimidine metabolism_Homo sapiens_hsa002400.19999328
95Estrogen signaling pathway_Homo sapiens_hsa049150.19079060
96MAPK signaling pathway_Homo sapiens_hsa040100.18668985
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.18625251
98RNA polymerase_Homo sapiens_hsa030200.17810975
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.17660506
100Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.17650864

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