C17ORF89

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)8.51838932
2viral transcription (GO:0019083)7.11119877
3translational termination (GO:0006415)6.73718002
4maturation of SSU-rRNA (GO:0030490)6.70920018
5deoxyribonucleoside monophosphate metabolic process (GO:0009162)6.28281177
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.04216019
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.02316172
8translational elongation (GO:0006414)5.95457108
9cotranslational protein targeting to membrane (GO:0006613)5.89525447
10protein targeting to ER (GO:0045047)5.88302995
11ribosomal small subunit assembly (GO:0000028)5.82623195
12chaperone-mediated protein transport (GO:0072321)5.80419700
13establishment of protein localization to endoplasmic reticulum (GO:0072599)5.62161717
14protein localization to endoplasmic reticulum (GO:0070972)5.58650864
15energy coupled proton transport, down electrochemical gradient (GO:0015985)5.56606188
16ATP synthesis coupled proton transport (GO:0015986)5.56606188
17regulation of mitochondrial translation (GO:0070129)5.44110214
18pyrimidine deoxyribonucleotide catabolic process (GO:0009223)5.36389091
19nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.29815723
20viral life cycle (GO:0019058)5.28507601
21cellular protein complex disassembly (GO:0043624)5.20125700
22establishment of protein localization to mitochondrial membrane (GO:0090151)5.14006755
23translational initiation (GO:0006413)4.87030214
24mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.83217700
25protein complex biogenesis (GO:0070271)4.82030777
26ribonucleoprotein complex biogenesis (GO:0022613)4.78211587
27respiratory electron transport chain (GO:0022904)4.71708869
28translation (GO:0006412)4.65453802
29mitochondrial respiratory chain complex assembly (GO:0033108)4.64862282
30electron transport chain (GO:0022900)4.59928932
31pyrimidine deoxyribonucleotide metabolic process (GO:0009219)4.57499498
32cellular component biogenesis (GO:0044085)4.55043128
33protein complex disassembly (GO:0043241)4.51750677
34pyrimidine nucleotide catabolic process (GO:0006244)4.50306121
35mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.48400840
36mitochondrial respiratory chain complex I assembly (GO:0032981)4.48400840
37NADH dehydrogenase complex assembly (GO:0010257)4.48400840
38GTP biosynthetic process (GO:0006183)4.46403449
39ribosomal large subunit biogenesis (GO:0042273)4.42241150
40protein targeting to mitochondrion (GO:0006626)4.39400411
41oxidative phosphorylation (GO:0006119)4.36189991
42pyrimidine nucleoside triphosphate metabolic process (GO:0009147)4.28936736
43UTP biosynthetic process (GO:0006228)4.27998313
44macromolecular complex disassembly (GO:0032984)4.26963549
45pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)4.20408859
46pseudouridine synthesis (GO:0001522)4.14576306
47guanosine-containing compound biosynthetic process (GO:1901070)4.10801108
48establishment of protein localization to mitochondrion (GO:0072655)4.06189553
49protein targeting to membrane (GO:0006612)4.03068442
50proteasome assembly (GO:0043248)4.02441376
51nucleobase-containing small molecule interconversion (GO:0015949)3.97909660
522-deoxyribonucleotide biosynthetic process (GO:0009265)3.97010278
53deoxyribose phosphate biosynthetic process (GO:0046385)3.97010278
54UTP metabolic process (GO:0046051)3.91515169
55CTP metabolic process (GO:0046036)3.90310484
56CTP biosynthetic process (GO:0006241)3.90310484
57deoxyribonucleotide catabolic process (GO:0009264)3.89444704
58protein localization to mitochondrion (GO:0070585)3.83223050
59base-excision repair, AP site formation (GO:0006285)3.80892596
60pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.80134162
61rRNA processing (GO:0006364)3.77767235
62purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.73915756
63deoxyribose phosphate catabolic process (GO:0046386)3.73594650
64purine nucleoside triphosphate biosynthetic process (GO:0009145)3.72008543
65ribosome biogenesis (GO:0042254)3.70693768
66nuclear-transcribed mRNA catabolic process (GO:0000956)3.69494760
67peptidyl-histidine modification (GO:0018202)3.68767971
68deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.61296316
69ribonucleoside triphosphate biosynthetic process (GO:0009201)3.60381452
70rRNA metabolic process (GO:0016072)3.59503950
71pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.55771011
72transcription elongation from RNA polymerase III promoter (GO:0006385)3.53583364
73termination of RNA polymerase III transcription (GO:0006386)3.53583364
74ATP biosynthetic process (GO:0006754)3.51024906
75mRNA catabolic process (GO:0006402)3.49634519
76metallo-sulfur cluster assembly (GO:0031163)3.46720050
77iron-sulfur cluster assembly (GO:0016226)3.46720050
78rRNA modification (GO:0000154)3.41595451
79cytochrome complex assembly (GO:0017004)3.41400727
802-deoxyribonucleotide metabolic process (GO:0009394)3.38558854
81telomere maintenance via semi-conservative replication (GO:0032201)3.37246177
82pyrimidine nucleotide biosynthetic process (GO:0006221)3.36441600
83protein neddylation (GO:0045116)3.34994891
84protein maturation by protein folding (GO:0022417)3.32919317
85mitochondrial transport (GO:0006839)3.32387297
86formation of translation preinitiation complex (GO:0001731)3.32230044
87RNA catabolic process (GO:0006401)3.30968859
88nucleoside triphosphate biosynthetic process (GO:0009142)3.29373377
89ncRNA 3-end processing (GO:0043628)3.24213419
90kinetochore assembly (GO:0051382)3.20526570
91deoxyribose phosphate metabolic process (GO:0019692)3.19270606
92RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.18724290
93tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.18724290
94DNA strand elongation involved in DNA replication (GO:0006271)3.18355326
95pyrimidine nucleotide metabolic process (GO:0006220)3.15068148
96negative regulation of RNA splicing (GO:0033119)3.11894782
97negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.10340874
98negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.09959860
99DNA strand elongation (GO:0022616)3.09776796
100respiratory chain complex IV assembly (GO:0008535)3.07096498

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_18555785_ChIP-Seq_MESCs_Mouse4.30922234
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.89947183
3HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.76068275
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.75365052
5E2F7_22180533_ChIP-Seq_HELA_Human3.63311091
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.47373382
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.30018427
8MYC_18358816_ChIP-ChIP_MESCs_Mouse3.24760986
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.16533215
10GABP_17652178_ChIP-ChIP_JURKAT_Human3.00982292
11XRN2_22483619_ChIP-Seq_HELA_Human2.73896041
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.70139114
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.68479597
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.66466377
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.61666319
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.60626221
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.60019572
18THAP11_20581084_ChIP-Seq_MESCs_Mouse2.59931742
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.58232321
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.54237849
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.42474577
22GABP_19822575_ChIP-Seq_HepG2_Human2.21239914
23DCP1A_22483619_ChIP-Seq_HELA_Human2.14722580
24CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.14550155
25E2F1_18555785_ChIP-Seq_MESCs_Mouse2.12043823
26TTF2_22483619_ChIP-Seq_HELA_Human2.08411790
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.01398462
28PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.00063192
29PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.90442731
30NELFA_20434984_ChIP-Seq_ESCs_Mouse1.90298324
31YY1_21170310_ChIP-Seq_MESCs_Mouse1.85762510
32ZNF263_19887448_ChIP-Seq_K562_Human1.85743954
33VDR_23849224_ChIP-Seq_CD4+_Human1.82162477
34FOXP3_21729870_ChIP-Seq_TREG_Human1.81046891
35CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.78660435
36FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.78124622
37TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.77895169
38ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.77828125
39SRF_21415370_ChIP-Seq_HL-1_Mouse1.77772382
40DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.77115978
41* VDR_21846776_ChIP-Seq_THP-1_Human1.75414978
42ZFX_18555785_ChIP-Seq_MESCs_Mouse1.64531377
43E2F4_17652178_ChIP-ChIP_JURKAT_Human1.60549704
44TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59235677
45TET1_21451524_ChIP-Seq_MESCs_Mouse1.57075667
46CTCF_18555785_ChIP-Seq_MESCs_Mouse1.53385711
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.52305351
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.49152795
49SRY_22984422_ChIP-ChIP_TESTIS_Rat1.47154550
50CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.44589291
51MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.42713691
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.41270937
53POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.36379860
54KDM5A_27292631_Chip-Seq_BREAST_Human1.35297121
55BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.34949409
56SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.34775240
57ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.31508726
58ERG_20887958_ChIP-Seq_HPC-7_Mouse1.31352492
59FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.31167491
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31153158
61NANOG_18555785_ChIP-Seq_MESCs_Mouse1.31006782
62MYCN_18555785_ChIP-Seq_MESCs_Mouse1.30807390
63FOXP1_21924763_ChIP-Seq_HESCs_Human1.30594224
64BP1_19119308_ChIP-ChIP_Hs578T_Human1.29972546
65CIITA_25753668_ChIP-Seq_RAJI_Human1.29646951
66E2F1_21310950_ChIP-Seq_MCF-7_Human1.27748685
67KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.26395899
68CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.26081809
69MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.23247177
70MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18698817
71E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18285236
72YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17370036
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16236149
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13865365
75* LXR_22292898_ChIP-Seq_THP-1_Human1.12675539
76CTCF_26484167_Chip-Seq_Bcells_Mouse1.09873762
77CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.08725829
78MYC_18940864_ChIP-ChIP_HL60_Human1.07865221
79GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07096453
80P68_20966046_ChIP-Seq_HELA_Human1.06996690
81BCL6_27268052_Chip-Seq_Bcells_Human1.04205291
82KLF4_18555785_ChIP-Seq_MESCs_Mouse1.03286479
83ELF1_20517297_ChIP-Seq_JURKAT_Human1.03112280
84SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.99736653
85MYC_22102868_ChIP-Seq_BL_Human0.99672374
86KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97310479
87SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.96321242
88HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93588423
89ELK1_19687146_ChIP-ChIP_HELA_Human0.93475875
90* SA1_27219007_Chip-Seq_ERYTHROID_Human0.93203853
91FOXM1_23109430_ChIP-Seq_U2OS_Human0.93176755
92TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.92767897
93OCT4_18692474_ChIP-Seq_MEFs_Mouse0.92604598
94* CTCF_21964334_Chip-Seq_Bcells_Human0.91836901
95TBX5_21415370_ChIP-Seq_HL-1_Mouse0.88587816
96MAF_26560356_Chip-Seq_TH2_Human0.86437129
97CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.86265712
98SOX2_18555785_ChIP-Seq_MESCs_Mouse0.86161994
99CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.85606493
100ELK1_22589737_ChIP-Seq_MCF10A_Human0.83490601

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.53335615
2MP0003693_abnormal_embryo_hatching3.79812855
3MP0002163_abnormal_gland_morphology3.38349693
4MP0003111_abnormal_nucleus_morphology3.09818002
5MP0002234_abnormal_pharynx_morphology3.06283337
6MP0003806_abnormal_nucleotide_metabolis3.05228208
7MP0003186_abnormal_redox_activity3.03321765
8MP0006292_abnormal_olfactory_placode2.96750095
9MP0008932_abnormal_embryonic_tissue2.82287721
10MP0006036_abnormal_mitochondrial_physio2.81777019
11MP0008058_abnormal_DNA_repair2.69691642
12MP0010094_abnormal_chromosome_stability2.68546916
13MP0004957_abnormal_blastocyst_morpholog2.58954339
14MP0002132_abnormal_respiratory_system2.32667144
15MP0003077_abnormal_cell_cycle2.32589731
16MP0003786_premature_aging2.24177940
17MP0000678_abnormal_parathyroid_gland2.21965957
18MP0008007_abnormal_cellular_replicative2.16444064
19MP0000049_abnormal_middle_ear2.11266461
20MP0008789_abnormal_olfactory_epithelium2.04602448
21MP0010030_abnormal_orbit_morphology1.98297346
22MP0002160_abnormal_reproductive_system1.78943702
23MP0003123_paternal_imprinting1.75262082
24MP0001905_abnormal_dopamine_level1.63466324
25MP0000372_irregular_coat_pigmentation1.62501325
26MP0009333_abnormal_splenocyte_physiolog1.61922405
27MP0005379_endocrine/exocrine_gland_phen1.59431191
28MP0005499_abnormal_olfactory_system1.56605118
29MP0005394_taste/olfaction_phenotype1.56605118
30MP0004858_abnormal_nervous_system1.53871440
31MP0002877_abnormal_melanocyte_morpholog1.48148307
32MP0006035_abnormal_mitochondrial_morpho1.41727011
33MP0000350_abnormal_cell_proliferation1.39445318
34MP0001529_abnormal_vocalization1.38099810
35MP0002837_dystrophic_cardiac_calcinosis1.33581966
36MP0000750_abnormal_muscle_regeneration1.29194081
37MP0005389_reproductive_system_phenotype1.29193381
38MP0002249_abnormal_larynx_morphology1.25614456
39MP0005501_abnormal_skin_physiology1.22138777
40MP0004145_abnormal_muscle_electrophysio1.21385223
41MP0000313_abnormal_cell_death1.21205858
42MP0005451_abnormal_body_composition1.20587239
43MP0009250_abnormal_appendicular_skeleto1.20466606
44MP0001727_abnormal_embryo_implantation1.16921211
45MP0005670_abnormal_white_adipose1.16819121
46MP0002938_white_spotting1.16572135
47MP0003718_maternal_effect1.14609462
48MP0003136_yellow_coat_color1.13940280
49MP0001293_anophthalmia1.13201077
50MP0000358_abnormal_cell_content/1.11486416
51MP0000490_abnormal_crypts_of1.11207591
52MP0009053_abnormal_anal_canal1.09669086
53MP0001919_abnormal_reproductive_system1.09113372
54MP0003315_abnormal_perineum_morphology1.08711947
55MP0002736_abnormal_nociception_after1.08060308
56MP0005330_cardiomyopathy1.05955119
57MP0002822_catalepsy1.05067018
58MP0004185_abnormal_adipocyte_glucose1.04931233
59MP0005623_abnormal_meninges_morphology1.04418173
60MP0000681_abnormal_thyroid_gland1.04063578
61MP0001881_abnormal_mammary_gland1.02307068
62MP0005408_hypopigmentation1.01400508
63MP0001764_abnormal_homeostasis0.96425710
64MP0001661_extended_life_span0.94944857
65MP0004233_abnormal_muscle_weight0.93656869
66MP0002019_abnormal_tumor_incidence0.87896973
67MP0009697_abnormal_copulation0.87841239
68MP0003137_abnormal_impulse_conducting0.86187439
69MP0003011_delayed_dark_adaptation0.83869532
70MP0005332_abnormal_amino_acid0.81754592
71MP0002210_abnormal_sex_determination0.80786819
72MP0001730_embryonic_growth_arrest0.76859603
73MP0005646_abnormal_pituitary_gland0.72938161
74MP0001873_stomach_inflammation0.72285471
75MP0001346_abnormal_lacrimal_gland0.71407031
76MP0002177_abnormal_outer_ear0.71270191
77MP0005266_abnormal_metabolism0.70516901
78MP0000343_altered_response_to0.70453328
79MP0000759_abnormal_skeletal_muscle0.67684231
80MP0002080_prenatal_lethality0.65327490
81MP0002697_abnormal_eye_size0.65030110
82MP0004142_abnormal_muscle_tone0.64876199
83MP0010307_abnormal_tumor_latency0.64434075
84MP0001697_abnormal_embryo_size0.64386915
85MP0002092_abnormal_eye_morphology0.64200121
86MP0003878_abnormal_ear_physiology0.63376234
87MP0005377_hearing/vestibular/ear_phenot0.63376234
88MP0002095_abnormal_skin_pigmentation0.62534963
89MP0001188_hyperpigmentation0.62322178
90MP0008873_increased_physiological_sensi0.60610744
91MP0003942_abnormal_urinary_system0.59478071
92MP0000762_abnormal_tongue_morphology0.59449335
93MP0003646_muscle_fatigue0.59254797
94MP0002233_abnormal_nose_morphology0.58498412
95MP0005083_abnormal_biliary_tract0.58133183
96MP0001145_abnormal_male_reproductive0.57859225
97MP0001542_abnormal_bone_strength0.56233848
98MP0002277_abnormal_respiratory_mucosa0.56092400
99MP0000858_altered_metastatic_potential0.55659429
100MP0000703_abnormal_thymus_morphology0.54134587

Predicted human phenotypes

RankGene SetZ-score
1Abnormal mitochondria in muscle tissue (HP:0008316)6.63883353
2Acute necrotizing encephalopathy (HP:0006965)6.55343820
3Acute encephalopathy (HP:0006846)5.65670454
4Mitochondrial inheritance (HP:0001427)5.64396083
5Abnormal activity of mitochondrial respiratory chain (HP:0011922)5.41479132
6Decreased activity of mitochondrial respiratory chain (HP:0008972)5.41479132
7Progressive macrocephaly (HP:0004481)5.19658534
8Increased CSF lactate (HP:0002490)5.01097702
9Hepatocellular necrosis (HP:0001404)4.96958837
10Increased intramyocellular lipid droplets (HP:0012240)4.90406453
11Reticulocytopenia (HP:0001896)4.80028102
12Abnormality of cells of the erythroid lineage (HP:0012130)4.58377563
13Hepatic necrosis (HP:0002605)4.55162951
14Increased muscle lipid content (HP:0009058)4.36631131
15Cerebral edema (HP:0002181)4.25860669
16Macrocytic anemia (HP:0001972)4.21613921
17Abnormal number of erythroid precursors (HP:0012131)3.95837168
183-Methylglutaconic aciduria (HP:0003535)3.84475188
19Increased hepatocellular lipid droplets (HP:0006565)3.82929624
20Exercise intolerance (HP:0003546)3.76533390
21Lactic acidosis (HP:0003128)3.75863781
22Aplasia/Hypoplasia of the sacrum (HP:0008517)3.60984903
23Increased serum lactate (HP:0002151)3.52975656
24Lipid accumulation in hepatocytes (HP:0006561)3.52675170
25Renal Fanconi syndrome (HP:0001994)3.51523866
26Respiratory failure (HP:0002878)3.49193459
27Microretrognathia (HP:0000308)3.39837082
28Respiratory difficulties (HP:0002880)3.28854192
29Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.18104734
30Pallor (HP:0000980)3.06048943
31Ragged-red muscle fibers (HP:0003200)3.00996583
32Leukodystrophy (HP:0002415)2.91688343
33Progressive muscle weakness (HP:0003323)2.83374686
34Microvesicular hepatic steatosis (HP:0001414)2.77157693
35Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.69539034
36Type I transferrin isoform profile (HP:0003642)2.59255450
37Muscle fiber atrophy (HP:0100295)2.55556930
38Exertional dyspnea (HP:0002875)2.52419880
39Testicular atrophy (HP:0000029)2.46660300
40Lethargy (HP:0001254)2.40018223
41Aplastic anemia (HP:0001915)2.34851208
42Hypoplastic left heart (HP:0004383)2.29527868
43Pancytopenia (HP:0001876)2.28287792
44Increased serum pyruvate (HP:0003542)2.27494800
45Emotional lability (HP:0000712)2.22466631
46Optic disc pallor (HP:0000543)2.21291843
47Absent thumb (HP:0009777)2.20363189
48Hyperthyroidism (HP:0000836)2.18469836
49Progressive microcephaly (HP:0000253)2.17485929
50Hyperglycinemia (HP:0002154)2.15117327
51Cleft eyelid (HP:0000625)2.14528010
52Cutaneous melanoma (HP:0012056)2.14345107
53Dicarboxylic aciduria (HP:0003215)2.12179299
54Abnormality of dicarboxylic acid metabolism (HP:0010995)2.12179299
55Squamous cell carcinoma (HP:0002860)2.09992435
56Degeneration of anterior horn cells (HP:0002398)2.04875316
57Abnormality of the anterior horn cell (HP:0006802)2.04875316
58Broad distal phalanx of finger (HP:0009836)2.03894188
59Achilles tendon contracture (HP:0001771)2.03078304
60Abnormality of glycolysis (HP:0004366)2.02800665
61CNS demyelination (HP:0007305)2.02780956
62Abnormal number of incisors (HP:0011064)2.02172157
63Abnormal protein glycosylation (HP:0012346)1.97568334
64Abnormal glycosylation (HP:0012345)1.97568334
65Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.97568334
66Abnormal protein N-linked glycosylation (HP:0012347)1.97568334
67Opisthotonus (HP:0002179)1.96825526
68Colon cancer (HP:0003003)1.94213161
69Double outlet right ventricle (HP:0001719)1.94210534
70Congenital malformation of the right heart (HP:0011723)1.94210534
71Multiple enchondromatosis (HP:0005701)1.92779927
72Cerebral hypomyelination (HP:0006808)1.92316496
73X-linked dominant inheritance (HP:0001423)1.90037818
74Dysphonia (HP:0001618)1.88446810
75Hypoplasia of the radius (HP:0002984)1.87356904
76Hypoplastic heart (HP:0001961)1.86316580
77Redundant skin (HP:0001582)1.82876696
78Sparse eyelashes (HP:0000653)1.82527201
79Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.82327188
80Abnormality of alanine metabolism (HP:0010916)1.82327188
81Hyperalaninemia (HP:0003348)1.82327188
82Rough bone trabeculation (HP:0100670)1.80513618
83Trismus (HP:0000211)1.79600508
84Gliosis (HP:0002171)1.79215590
85Patent foramen ovale (HP:0001655)1.77773015
86Concave nail (HP:0001598)1.77492845
87Reduced subcutaneous adipose tissue (HP:0003758)1.76549351
88Gout (HP:0001997)1.72370709
89Horseshoe kidney (HP:0000085)1.71811291
90Abnormality of renal resorption (HP:0011038)1.71521444
91Abnormality of the Achilles tendon (HP:0005109)1.69672382
92Partial duplication of thumb phalanx (HP:0009944)1.68533466
93Reduced antithrombin III activity (HP:0001976)1.67169497
94Generalized aminoaciduria (HP:0002909)1.64485428
95Partial duplication of the phalanx of hand (HP:0009999)1.63429922
96Truncus arteriosus (HP:0001660)1.63360314
97Absent rod-and cone-mediated responses on ERG (HP:0007688)1.58513514
98Myokymia (HP:0002411)1.57025460
99Death in infancy (HP:0001522)1.55807594
100Blindness (HP:0000618)1.55469911

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME26.66561985
2VRK24.74743475
3BUB13.07642285
4STK163.04263651
5BCKDK2.97602609
6PIM22.93875487
7CDC72.76270115
8ARAF2.68939863
9TESK22.53016165
10KDR2.43883533
11ABL22.12272829
12NEK12.11216167
13SCYL22.06802247
14MAP3K111.97121840
15SMG11.90920133
16IRAK31.89292030
17VRK11.82519343
18TESK11.77841215
19AURKA1.73021839
20SRPK11.71877250
21TLK11.69442993
22NME11.51442933
23LIMK11.43061398
24LRRK21.40574369
25MOS1.25718890
26PDK21.24763476
27CHEK21.22360983
28ZAK1.19888310
29CSNK1G31.15512702
30TAF11.14920847
31AURKB1.14473345
32BRAF1.13797475
33NUAK11.11316691
34ILK1.09501224
35EIF2AK11.05879175
36DAPK31.03533674
37DYRK21.03202233
38RPS6KA51.02506244
39DAPK11.02229343
40PLK41.00176740
41TAOK20.98940912
42RPS6KA40.98414689
43PLK10.96227206
44CSNK1A1L0.91259908
45ATR0.89671064
46CCNB10.87518732
47MAP2K70.82794840
48CDK80.82214471
49PBK0.82053395
50CDK70.80084094
51PRKD30.79543547
52CSNK2A20.75880892
53RPS6KB20.74898905
54CSNK1G20.74699247
55GRK50.72915291
56CDK190.71889083
57BRSK10.70640832
58CSNK1G10.69028339
59CDK40.68178051
60CSNK2A10.67172967
61GRK70.64761400
62DMPK0.64511512
63DYRK30.63481010
64PAK10.62625692
65CHEK10.62140663
66CAMK2G0.60008934
67MAPKAPK50.59415057
68STK40.56498541
69PRKCI0.53853860
70CDK11A0.51182432
71TTK0.50683179
72NEK20.49535058
73CDK140.46402236
74MAP3K80.45070774
75CDK150.43773219
76MUSK0.41116453
77AKT20.37475463
78PIM10.37358743
79CDK180.36975401
80STK100.36856716
81EPHA20.34989027
82IKBKB0.34117294
83CDK20.33717683
84MAP4K20.32832705
85MAPK110.32077068
86PLK30.30834301
87IRAK20.29085741
88ICK0.28133426
89EIF2AK20.27195932
90MAPKAPK30.27183014
91CAMK2D0.27176688
92CAMK2B0.24978978
93CDK90.24440154
94PAK40.24242695
95CSNK1A10.23583578
96CSNK1E0.22934911
97ATM0.22824110
98PRKCD0.21514018
99RPS6KL10.21356931
100RPS6KC10.21356931

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.40287231
2Oxidative phosphorylation_Homo sapiens_hsa001904.20859302
3DNA replication_Homo sapiens_hsa030303.79666883
4Parkinsons disease_Homo sapiens_hsa050123.66603938
5Proteasome_Homo sapiens_hsa030503.39543590
6Sulfur relay system_Homo sapiens_hsa041223.32319548
7Base excision repair_Homo sapiens_hsa034102.89257010
8Huntingtons disease_Homo sapiens_hsa050162.71719118
9RNA polymerase_Homo sapiens_hsa030202.66004151
10Pyrimidine metabolism_Homo sapiens_hsa002402.60830853
11Mismatch repair_Homo sapiens_hsa034302.58909089
12Alzheimers disease_Homo sapiens_hsa050102.54677260
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.31347476
14Spliceosome_Homo sapiens_hsa030402.17541980
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.17278441
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.07014844
17Homologous recombination_Homo sapiens_hsa034401.99150456
18Nucleotide excision repair_Homo sapiens_hsa034201.97218706
19Cardiac muscle contraction_Homo sapiens_hsa042601.72919726
20Protein export_Homo sapiens_hsa030601.69906849
21Fanconi anemia pathway_Homo sapiens_hsa034601.64514226
22One carbon pool by folate_Homo sapiens_hsa006701.55808702
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.46807849
24Purine metabolism_Homo sapiens_hsa002301.35094691
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.34922009
26Sulfur metabolism_Homo sapiens_hsa009201.31437196
27Folate biosynthesis_Homo sapiens_hsa007901.29005574
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.24027825
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.22947476
30RNA transport_Homo sapiens_hsa030131.20069377
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.19414467
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.11758813
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.08735802
34Biosynthesis of amino acids_Homo sapiens_hsa012301.06717578
35Glutathione metabolism_Homo sapiens_hsa004800.93581777
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93134671
37Vitamin B6 metabolism_Homo sapiens_hsa007500.92462515
38RNA degradation_Homo sapiens_hsa030180.90560743
39Fatty acid elongation_Homo sapiens_hsa000620.90475430
40Metabolic pathways_Homo sapiens_hsa011000.85686645
41Carbon metabolism_Homo sapiens_hsa012000.84925043
42Pyruvate metabolism_Homo sapiens_hsa006200.84824278
43Cell cycle_Homo sapiens_hsa041100.83385379
44Systemic lupus erythematosus_Homo sapiens_hsa053220.79184961
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79154654
46Arginine and proline metabolism_Homo sapiens_hsa003300.75349793
47Basal transcription factors_Homo sapiens_hsa030220.72106890
48Drug metabolism - other enzymes_Homo sapiens_hsa009830.71660677
49Phenylalanine metabolism_Homo sapiens_hsa003600.69923172
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66980972
51Pentose phosphate pathway_Homo sapiens_hsa000300.64888475
52Galactose metabolism_Homo sapiens_hsa000520.64598780
53Peroxisome_Homo sapiens_hsa041460.63829758
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63698651
55Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.60732088
56p53 signaling pathway_Homo sapiens_hsa041150.60109826
57Primary immunodeficiency_Homo sapiens_hsa053400.57636778
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55233105
59Non-homologous end-joining_Homo sapiens_hsa034500.53746384
60N-Glycan biosynthesis_Homo sapiens_hsa005100.52793131
61Tyrosine metabolism_Homo sapiens_hsa003500.48183998
62Fructose and mannose metabolism_Homo sapiens_hsa000510.43937024
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.41636746
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.40190450
65Epstein-Barr virus infection_Homo sapiens_hsa051690.37936503
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35197951
67Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.30894923
68Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.30648396
69Bladder cancer_Homo sapiens_hsa052190.30417489
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30125191
71Alcoholism_Homo sapiens_hsa050340.30000713
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29490286
73Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.22647940
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.21987073
75Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.20953036
76Fatty acid degradation_Homo sapiens_hsa000710.19363958
77Fatty acid metabolism_Homo sapiens_hsa012120.19356708
78beta-Alanine metabolism_Homo sapiens_hsa004100.18226580
79mRNA surveillance pathway_Homo sapiens_hsa030150.18152010
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.17153077
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.16924121
82Collecting duct acid secretion_Homo sapiens_hsa049660.16917189
83Selenocompound metabolism_Homo sapiens_hsa004500.16683813
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.16443587
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.14419105
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.13408080
87Basal cell carcinoma_Homo sapiens_hsa052170.13300520
88Vibrio cholerae infection_Homo sapiens_hsa051100.11591536
89Herpes simplex infection_Homo sapiens_hsa051680.11222206
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.09666621
91HTLV-I infection_Homo sapiens_hsa051660.08304321
92Propanoate metabolism_Homo sapiens_hsa006400.06572394
93Antigen processing and presentation_Homo sapiens_hsa046120.05436559
94Arachidonic acid metabolism_Homo sapiens_hsa005900.02209134
95Shigellosis_Homo sapiens_hsa051310.02188205
96Regulation of autophagy_Homo sapiens_hsa041400.02018941
97Oocyte meiosis_Homo sapiens_hsa041140.00659522
98Steroid biosynthesis_Homo sapiens_hsa00100-0.0166046
99Hedgehog signaling pathway_Homo sapiens_hsa04340-0.0134230
100Synaptic vesicle cycle_Homo sapiens_hsa04721-0.0065684

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