C17ORF78

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)8.88777657
2regulation of guanylate cyclase activity (GO:0031282)7.75690070
3lipoprotein transport (GO:0042953)7.72351703
4epoxygenase P450 pathway (GO:0019373)7.08718885
5NADH metabolic process (GO:0006734)6.94896647
6regulation of bile acid biosynthetic process (GO:0070857)6.79858285
7intestinal absorption (GO:0050892)6.72595321
8fat-soluble vitamin biosynthetic process (GO:0042362)6.64961456
9positive regulation of guanylate cyclase activity (GO:0031284)6.20339820
10hormone catabolic process (GO:0042447)5.68700449
11fructose metabolic process (GO:0006000)5.48980013
12regulation of systemic arterial blood pressure by hormone (GO:0001990)5.48901751
13regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)5.48901751
14endocrine process (GO:0050886)5.48901751
15drug metabolic process (GO:0017144)5.16033555
16regulation of triglyceride catabolic process (GO:0010896)5.12499002
17adhesion of symbiont to host cell (GO:0044650)5.10505019
18virion attachment to host cell (GO:0019062)5.10505019
19regulation of systemic arterial blood pressure (GO:0003073)4.97095637
20peptide hormone processing (GO:0016486)4.79313081
21regulation of cellular extravasation (GO:0002691)4.79189292
22regulation of cGMP biosynthetic process (GO:0030826)4.70826944
23cellular glucuronidation (GO:0052695)4.70207281
24glucuronate metabolic process (GO:0019585)4.62635233
25uronic acid metabolic process (GO:0006063)4.62635233
26vitamin A metabolic process (GO:0006776)4.54313981
27digestion (GO:0007586)4.50508428
28diacylglycerol metabolic process (GO:0046339)4.49431666
29very-low-density lipoprotein particle assembly (GO:0034379)4.44310485
30peptide catabolic process (GO:0043171)4.43239135
31receptor guanylyl cyclase signaling pathway (GO:0007168)4.40283874
32urea cycle (GO:0000050)4.39514708
33bile acid and bile salt transport (GO:0015721)4.39461735
34adhesion of symbiont to host (GO:0044406)4.29467544
35urea metabolic process (GO:0019627)4.23543378
36glycolipid catabolic process (GO:0019377)4.21238470
37flavonoid metabolic process (GO:0009812)4.19172055
38glycosphingolipid catabolic process (GO:0046479)4.18976370
39vitamin transmembrane transport (GO:0035461)4.12698521
40renal system process involved in regulation of blood volume (GO:0001977)4.11374201
41plasma lipoprotein particle assembly (GO:0034377)4.04642023
42regulation of vitamin metabolic process (GO:0030656)4.03637564
43drinking behavior (GO:0042756)3.98130407
44regulation of cGMP metabolic process (GO:0030823)3.96569027
45fat-soluble vitamin metabolic process (GO:0006775)3.95282214
46lipoprotein metabolic process (GO:0042157)3.91909995
47vitamin transport (GO:0051180)3.91033591
48antibacterial humoral response (GO:0019731)3.89673826
49cellular response to nitric oxide (GO:0071732)3.89163140
50alkaloid metabolic process (GO:0009820)3.85958856
51nitrogen cycle metabolic process (GO:0071941)3.84817193
52drug catabolic process (GO:0042737)3.82689100
53mRNA modification (GO:0016556)3.79378591
54antimicrobial humoral response (GO:0019730)3.76401824
55homocysteine metabolic process (GO:0050667)3.69852360
56exogenous drug catabolic process (GO:0042738)3.66101504
57protein-lipid complex assembly (GO:0065005)3.61431653
58maintenance of gastrointestinal epithelium (GO:0030277)3.60652384
59cGMP biosynthetic process (GO:0006182)3.59938609
60regulation of protein glycosylation (GO:0060049)3.59786621
61positive regulation of cGMP biosynthetic process (GO:0030828)3.58953839
62glutamine family amino acid biosynthetic process (GO:0009084)3.49702706
63positive regulation of pseudopodium assembly (GO:0031274)3.46552937
64midgut development (GO:0007494)3.45634698
65ceramide catabolic process (GO:0046514)3.45133958
66glycerol metabolic process (GO:0006071)3.45049989
67bile acid metabolic process (GO:0008206)3.43726218
68cellular response to reactive nitrogen species (GO:1902170)3.42042498
69fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.39885029
70auditory receptor cell differentiation (GO:0042491)3.38710153
71sulfate transmembrane transport (GO:1902358)3.37600633
72drug transport (GO:0015893)3.36594045
73positive regulation of lipoprotein lipase activity (GO:0051006)3.35651421
74positive regulation of triglyceride lipase activity (GO:0061365)3.35651421
75phospholipid efflux (GO:0033700)3.34629428
76sphingomyelin metabolic process (GO:0006684)3.34462816
77cytidine metabolic process (GO:0046087)3.34347690
78cytidine catabolic process (GO:0006216)3.34347690
79cytidine deamination (GO:0009972)3.34347690
80positive regulation of glycoprotein biosynthetic process (GO:0010560)3.33782379
81urate metabolic process (GO:0046415)3.33214388
82vitamin biosynthetic process (GO:0009110)3.32452439
83glycosylceramide metabolic process (GO:0006677)3.31843248
84response to nitric oxide (GO:0071731)3.31328236
85heme transport (GO:0015886)3.28531203
86sphingolipid catabolic process (GO:0030149)3.26610893
87cobalamin metabolic process (GO:0009235)3.26581898
88digestive system process (GO:0022600)3.25859154
89vitamin D metabolic process (GO:0042359)3.22533125
90regulation of cholesterol esterification (GO:0010872)3.22070466
91arginine metabolic process (GO:0006525)3.21106003
92sulfur compound transport (GO:0072348)3.17869861
93glomerulus development (GO:0032835)3.17794606
94positive regulation of cGMP metabolic process (GO:0030825)3.17145482
95sexual reproduction (GO:0019953)3.15474664
96membrane lipid catabolic process (GO:0046466)3.11976558
97actin filament depolymerization (GO:0030042)3.11242358
98regulation of pseudopodium assembly (GO:0031272)3.11036807
99drug transmembrane transport (GO:0006855)3.10511073
100angiotensin maturation (GO:0002003)11.6532222

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CDX2_20551321_ChIP-Seq_CACO-2_Human5.05828991
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.94014757
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.75795388
4GATA1_22025678_ChIP-Seq_K562_Human3.26062519
5HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.23548008
6GATA4_25053715_ChIP-Seq_YYC3_Human2.94614737
7SOX2_27498859_Chip-Seq_STOMACH_Mouse2.70303281
8CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.62811997
9EGR1_23403033_ChIP-Seq_LIVER_Mouse2.50003581
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.42296079
11LXR_22158963_ChIP-Seq_LIVER_Mouse2.37154145
12CDX2_19796622_ChIP-Seq_MESCs_Mouse2.35404082
13RXR_22158963_ChIP-Seq_LIVER_Mouse2.28991590
14GATA6_25053715_ChIP-Seq_YYC3_Human2.27240265
15BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human2.23550668
16SOX2_20726797_ChIP-Seq_SW620_Human2.11588652
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.11216940
18PPARA_22158963_ChIP-Seq_LIVER_Mouse2.04464828
19TRIM28_21343339_ChIP-Seq_HEK293_Human2.02484563
20FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.86664075
21PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.75040289
22* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.74002341
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.73218626
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.71611167
25FOXO3_23340844_ChIP-Seq_DLD1_Human1.71091182
26PPAR_26484153_Chip-Seq_NCI-H1993_Human1.69780625
27PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.64266287
28CDX2_22108803_ChIP-Seq_LS180_Human1.55474771
29FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.54721523
30TCF4_18268006_ChIP-ChIP_LS174T_Human1.51002664
31NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.50742516
32RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.45421774
33RXR_22108803_ChIP-Seq_LS180_Human1.40969897
34HNF4A_19822575_ChIP-Seq_HepG2_Human1.39641847
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.39640056
36FOXA1_25552417_ChIP-Seq_VCAP_Human1.34330780
37* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28567636
38IRF8_21731497_ChIP-ChIP_J774_Mouse1.24589100
39BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.15332700
40GATA2_19941826_ChIP-Seq_K562_Human1.14741044
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12778100
42FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.12322925
43BCAT_22108803_ChIP-Seq_LS180_Human1.11001738
44FOXA2_19822575_ChIP-Seq_HepG2_Human1.06026146
45PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05775734
46NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05115894
47* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04845458
48EGR1_19032775_ChIP-ChIP_M12_Human1.02914436
49CLOCK_20551151_ChIP-Seq_293T_Human1.02133638
50NANOG_20526341_ChIP-Seq_ESCs_Human1.02067761
51FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01781927
52PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.98986945
53CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.98407183
54LXR_22292898_ChIP-Seq_THP-1_Human0.98212868
55VDR_24787735_ChIP-Seq_THP-1_Human0.97567741
56NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.97360547
57KLF5_25053715_ChIP-Seq_YYC3_Human0.96064300
58KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95100670
59* TP63_23658742_ChIP-Seq_EP156T_Human0.94999622
60CEBPB_22108803_ChIP-Seq_LS180_Human0.94771495
61STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.93464750
62PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.93428338
63VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.90936914
64* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.90642815
65AUTS2_25519132_ChIP-Seq_293T-REX_Human0.88453663
66TCF4_22108803_ChIP-Seq_LS180_Human0.88155869
67SMAD_19615063_ChIP-ChIP_OVARY_Human0.87216608
68PRDM14_20953172_ChIP-Seq_ESCs_Human0.86898919
69GATA2_21666600_ChIP-Seq_HMVEC_Human0.86746524
70HNFA_21074721_ChIP-Seq_CACO-2_Human0.86063201
71ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.85342045
72CJUN_26792858_Chip-Seq_BT549_Human0.84884895
73SA1_27219007_Chip-Seq_Bcells_Human0.84102521
74CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.83744464
75AR_20517297_ChIP-Seq_VCAP_Human0.82711717
76SMAD3_21741376_ChIP-Seq_HESCs_Human0.82497167
77ETV2_25802403_ChIP-Seq_MESCs_Mouse0.82497051
78NCOR_22424771_ChIP-Seq_293T_Human0.82404429
79JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.82366518
80TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.82306233
81DROSHA_22980978_ChIP-Seq_HELA_Human0.82140847
82P63_26484246_Chip-Seq_KERATINOCYTES_Human0.81171891
83GATA1_19941826_ChIP-Seq_K562_Human0.80884558
84TCF3_18692474_ChIP-Seq_MEFs_Mouse0.79578816
85EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.79310194
86VDR_22108803_ChIP-Seq_LS180_Human0.79213078
87CBP_21632823_ChIP-Seq_H3396_Human0.78946320
88TP53_18474530_ChIP-ChIP_U2OS_Human0.78829002
89GATA3_24758297_ChIP-Seq_MCF-7_Human0.78366554
90TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75681241
91NFYA_21822215_ChIP-Seq_K562_Human0.75129035
92MYC_19829295_ChIP-Seq_ESCs_Human0.74914243
93GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.74490484
94CTCF_27219007_Chip-Seq_Bcells_Human0.74469295
95FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.73668730
96PCGF2_27294783_Chip-Seq_NPCs_Mouse0.73666807
97RAD21_21589869_ChIP-Seq_MESCs_Mouse0.73049160
98KAP1_22055183_ChIP-Seq_ESCs_Mouse0.72890981
99FOXA1_25329375_ChIP-Seq_VCAP_Human0.72489443
100FOXA1_27270436_Chip-Seq_PROSTATE_Human0.72489443

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis9.61529008
2MP0005085_abnormal_gallbladder_physiolo5.08996259
3MP0001666_abnormal_nutrient_absorption4.96494737
4MP0003183_abnormal_peptide_metabolism4.64326536
5MP0004147_increased_porphyrin_level4.05132651
6MP0004019_abnormal_vitamin_homeostasis3.89055840
7MP0005365_abnormal_bile_salt3.88333976
8MP0002139_abnormal_hepatobiliary_system3.50283597
9MP0004264_abnormal_extraembryonic_tissu3.40767005
10MP0009840_abnormal_foam_cell3.37954889
11MP0009379_abnormal_foot_pigmentation3.22647055
12MP0010155_abnormal_intestine_physiology2.53684745
13MP0010234_abnormal_vibrissa_follicle2.40527673
14MP0010329_abnormal_lipoprotein_level2.36585551
15MP0005409_darkened_coat_color2.06517062
16MP0005332_abnormal_amino_acid1.96725039
17MP0001664_abnormal_digestion1.94792158
18MP0009643_abnormal_urine_homeostasis1.86260605
19MP0003252_abnormal_bile_duct1.83375342
20MP0000538_abnormal_urinary_bladder1.78780878
21MP0003866_abnormal_defecation1.74002561
22MP0003868_abnormal_feces_composition1.72701871
23MP0010352_gastrointestinal_tract_polyps1.70983760
24MP0001764_abnormal_homeostasis1.61050270
25MP0000490_abnormal_crypts_of1.55553497
26MP0003806_abnormal_nucleotide_metabolis1.52387075
27MP0005670_abnormal_white_adipose1.51392073
28MP0003718_maternal_effect1.49679138
29MP0005166_decreased_susceptibility_to1.39846249
30MP0005636_abnormal_mineral_homeostasis1.38221840
31MP0001765_abnormal_ion_homeostasis1.35891060
32MP0003879_abnormal_hair_cell1.34158923
33MP0001188_hyperpigmentation1.30155757
34MP0002118_abnormal_lipid_homeostasis1.29004334
35MP0005448_abnormal_energy_balance1.27853219
36MP0000477_abnormal_intestine_morphology1.25905639
37MP0001501_abnormal_sleep_pattern1.25851815
38MP0002876_abnormal_thyroid_physiology1.23913181
39MP0004270_analgesia1.21872144
40MP0000678_abnormal_parathyroid_gland1.20469937
41MP0002136_abnormal_kidney_physiology1.20207328
42MP0002396_abnormal_hematopoietic_system1.17738610
43MP0002822_catalepsy1.14097243
44MP0005535_abnormal_body_temperature1.08847036
45MP0002971_abnormal_brown_adipose1.07779794
46MP0001873_stomach_inflammation1.01264065
47MP0001485_abnormal_pinna_reflex0.98280187
48MP0004858_abnormal_nervous_system0.97820506
49MP0005584_abnormal_enzyme/coenzyme_acti0.95160467
50MP0000462_abnormal_digestive_system0.95153773
51MP0001756_abnormal_urination0.94557199
52MP0000609_abnormal_liver_physiology0.94091879
53MP0001663_abnormal_digestive_system0.92646145
54MP0000230_abnormal_systemic_arterial0.92365752
55MP0004043_abnormal_pH_regulation0.90742760
56MP0004782_abnormal_surfactant_physiolog0.87987559
57MP0009115_abnormal_fat_cell0.87254058
58MP0005174_abnormal_tail_pigmentation0.85297270
59MP0005319_abnormal_enzyme/_coenzyme0.85252370
60MP0001845_abnormal_inflammatory_respons0.77561393
61MP0002098_abnormal_vibrissa_morphology0.76338439
62MP0008469_abnormal_protein_level0.75091941
63MP0005381_digestive/alimentary_phenotyp0.73789397
64MP0009642_abnormal_blood_homeostasis0.73603830
65MP0008872_abnormal_physiological_respon0.71132011
66MP0002078_abnormal_glucose_homeostasis0.61997006
67MP0003045_fibrosis0.60738156
68MP0006138_congestive_heart_failure0.60430000
69MP0008875_abnormal_xenobiotic_pharmacok0.59380861
70MP0005451_abnormal_body_composition0.59211629
71MP0009764_decreased_sensitivity_to0.58907346
72MP0003953_abnormal_hormone_level0.57237781
73MP0000015_abnormal_ear_pigmentation0.57184699
74MP0002138_abnormal_hepatobiliary_system0.56836556
75MP0005395_other_phenotype0.56570449
76MP0000249_abnormal_blood_vessel0.55270236
77MP0000465_gastrointestinal_hemorrhage0.54837593
78MP0000516_abnormal_urinary_system0.54551044
79MP0005367_renal/urinary_system_phenotyp0.54551044
80MP0006082_CNS_inflammation0.54457955
81MP0002166_altered_tumor_susceptibility0.54135737
82MP0009785_altered_susceptibility_to0.54086552
83MP0003300_gastrointestinal_ulcer0.52921042
84MP0005334_abnormal_fat_pad0.50585055
85MP0002837_dystrophic_cardiac_calcinosis0.49797955
86MP0004484_altered_response_of0.46365910
87MP0002069_abnormal_eating/drinking_beha0.45342534
88MP0002896_abnormal_bone_mineralization0.44730216
89MP0005376_homeostasis/metabolism_phenot0.42088736
90MP0003638_abnormal_response/metabolism_0.41906753
91MP0003724_increased_susceptibility_to0.40224300
92MP0005666_abnormal_adipose_tissue0.39999091
93MP0008775_abnormal_heart_ventricle0.39600623
94MP0002796_impaired_skin_barrier0.39447217
95MP0000537_abnormal_urethra_morphology0.38977938
96MP0002135_abnormal_kidney_morphology0.38413003
97MP0001835_abnormal_antigen_presentation0.38236388
98MP0002909_abnormal_adrenal_gland0.37925952
99MP0000427_abnormal_hair_cycle0.37019812
100MP0005310_abnormal_salivary_gland0.36872879

Predicted human phenotypes

RankGene SetZ-score
1Hydroxyprolinuria (HP:0003080)7.68319117
2Abnormality of proline metabolism (HP:0010907)7.68319117
3Malnutrition (HP:0004395)7.28854330
4Chronic diarrhea (HP:0002028)6.14316511
5Hypobetalipoproteinemia (HP:0003563)6.13414729
6Abnormality of the vitamin B12 metabolism (HP:0004341)5.58201998
7Abnormality of vitamin B metabolism (HP:0004340)5.38386074
8Acanthocytosis (HP:0001927)5.33684793
9Ileus (HP:0002595)5.00239571
10Fat malabsorption (HP:0002630)4.93469715
11Widely patent fontanelles and sutures (HP:0004492)4.73316343
12Confusion (HP:0001289)4.54291289
13Hyperglycinuria (HP:0003108)4.46254823
14Abnormality of vitamin metabolism (HP:0100508)4.20242174
15Glycosuria (HP:0003076)4.11510095
16Abnormality of urine glucose concentration (HP:0011016)4.11510095
17Pigmentary retinal degeneration (HP:0001146)4.09687220
18Nausea (HP:0002018)3.70296264
19Proximal tubulopathy (HP:0000114)3.69409171
20Systemic lupus erythematosus (HP:0002725)3.63868591
21Abnormality of serine family amino acid metabolism (HP:0010894)3.60487949
22Abnormality of glycine metabolism (HP:0010895)3.60487949
23Decreased circulating renin level (HP:0003351)3.42591243
24Wide cranial sutures (HP:0010537)3.41867761
25Facial shape deformation (HP:0011334)3.41531401
26Potter facies (HP:0002009)3.41531401
27Nephrolithiasis (HP:0000787)3.34153305
28Congenital sensorineural hearing impairment (HP:0008527)3.31784244
29Xanthomatosis (HP:0000991)3.27245650
30Thin bony cortex (HP:0002753)3.24865783
31Megaloblastic anemia (HP:0001889)3.15235406
32Steatorrhea (HP:0002570)3.11986660
33Increased purine levels (HP:0004368)3.09903160
34Hyperuricemia (HP:0002149)3.09903160
35Posterior subcapsular cataract (HP:0007787)3.08240195
36Abdominal distention (HP:0003270)2.98188987
37Abnormality of aspartate family amino acid metabolism (HP:0010899)2.95558710
38Hypolipoproteinemia (HP:0010981)2.95370724
39Alkalosis (HP:0001948)2.90257614
40Hyperactive renin-angiotensin system (HP:0000841)2.86668283
41Metabolic alkalosis (HP:0200114)2.85350616
42Epidermoid cyst (HP:0200040)2.84274342
43Hypophosphatemia (HP:0002148)2.83916506
44Abnormality of monocarboxylic acid metabolism (HP:0010996)2.76344389
45Abnormality of purine metabolism (HP:0004352)2.75385236
46Abnormal urine phosphate concentration (HP:0012599)2.70309868
47Enlarged epiphyses (HP:0010580)2.66206759
48Hyperphosphaturia (HP:0003109)2.59420503
49Hyperammonemia (HP:0001987)2.58404194
50Abnormality of renin-angiotensin system (HP:0000847)2.49803106
51Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.48020220
52Hyperparathyroidism (HP:0000843)2.47086412
53Focal segmental glomerulosclerosis (HP:0000097)2.41803640
54Hypotension (HP:0002615)2.40491007
55Abnormality of nucleobase metabolism (HP:0010932)2.38927007
56Abnormality of small intestinal villus morphology (HP:0011472)2.35275912
57Villous atrophy (HP:0011473)2.35275912
58Abnormal glucose tolerance (HP:0001952)2.33142494
59Subcapsular cataract (HP:0000523)2.30980319
60Poikilocytosis (HP:0004447)2.29877642
61Metabolic acidosis (HP:0001942)2.29253438
62Delayed epiphyseal ossification (HP:0002663)2.27277146
63Abnormality of the costochondral junction (HP:0000919)2.23294718
64Eczematoid dermatitis (HP:0000976)2.20488810
65Gout (HP:0001997)2.19805898
66Abnormality of sulfur amino acid metabolism (HP:0004339)2.16885571
67Right ventricular cardiomyopathy (HP:0011663)2.15260906
68Abnormal albumin level (HP:0012116)2.10777256
69Hypoalbuminemia (HP:0003073)2.10777256
70Protuberant abdomen (HP:0001538)2.01896674
71Dicarboxylic aciduria (HP:0003215)2.00011094
72Abnormality of dicarboxylic acid metabolism (HP:0010995)2.00011094
73Abnormality of glutamine family amino acid metabolism (HP:0010902)10.9768715
74Generalized aminoaciduria (HP:0002909)1.96593722
75Irritability (HP:0000737)1.95552766
76Abnormality of magnesium homeostasis (HP:0004921)1.94410583
77Hyperphosphatemia (HP:0002905)1.93972452
78Pancreatitis (HP:0001733)1.93365497
79Renal tubular acidosis (HP:0001947)1.92498698
80Gastrointestinal dysmotility (HP:0002579)1.91159451
81Hemorrhage of the eye (HP:0011885)1.85652249
82Glomerulosclerosis (HP:0000096)1.84636705
83Abnormal biliary tract morphology (HP:0012440)1.83420277
84Cerebral palsy (HP:0100021)1.82161883
85Petechiae (HP:0000967)1.81409728
86White forelock (HP:0002211)1.81390763
87Chorioretinal atrophy (HP:0000533)1.81090245
88Renal tubular dysfunction (HP:0000124)1.78206143
89Glomerulonephritis (HP:0000099)1.76299292
90Dehydration (HP:0001944)1.75715470
91Gingivitis (HP:0000230)1.73746428
92Biliary tract neoplasm (HP:0100574)1.72184682
93Patchy hypopigmentation of hair (HP:0011365)1.71990281
94Multiple lipomas (HP:0001012)1.71617195
95Conjugated hyperbilirubinemia (HP:0002908)1.68971020
96Hypocalcemia (HP:0002901)1.68207862
97Lethargy (HP:0001254)1.67441811
98Symptomatic seizures (HP:0011145)1.64733418
99Hypokalemia (HP:0002900)1.60890980
100Metaphyseal irregularity (HP:0003025)1.60632618

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B9.16951436
2MST1R3.70643081
3ERN13.54974893
4PRKG23.43411481
5MAP3K102.99769914
6RIPK12.71889576
7STK392.53829956
8EPHA32.30244885
9OXSR12.17485572
10EPHA22.06971327
11MAP3K22.01864003
12STK38L1.96132610
13PDK21.88434965
14AKT31.84657104
15LATS11.74820094
16FRK1.72844550
17FGFR41.58864568
18MST41.57190923
19NLK1.54348222
20TNIK1.49734810
21TYK21.42709976
22EPHA41.40933893
23EPHB21.38792709
24MET1.36116868
25PTK61.30192919
26MAP3K121.30171613
27DDR21.25250558
28STK241.17524590
29TESK21.15231228
30FGFR31.10409774
31MAP2K21.04072823
32GRK61.03927551
33EPHB11.00796627
34PIK3CA0.99196850
35MYLK0.98821877
36IRAK10.98403152
37MAP3K10.97544926
38MATK0.95814004
39FER0.94930632
40PRKAA20.91220112
41MAP4K10.91040084
42PDPK10.91039508
43ERBB20.83181305
44PIM10.76388408
45STK380.76139177
46MAP2K60.76094238
47STK30.73326361
48PRKACG0.71394040
49PRPF4B0.71031164
50CASK0.70321749
51GRK10.68034087
52CDC42BPA0.61734065
53TESK10.60685706
54DAPK20.58070727
55PDK10.56849871
56PRKCA0.55864812
57PRKCZ0.55489171
58RIPK40.55101798
59MAPK110.54329696
60BMPR20.53654207
61PIK3CG0.53314391
62YES10.52972919
63LMTK20.48425620
64CAMK2D0.47859438
65NEK10.47415212
66JAK10.45189282
67NEK60.44921002
68TAOK10.43177503
69ABL20.42782446
70MELK0.41850649
71PRKCD0.38796142
72SRC0.38368846
73DYRK1B0.38291210
74ITK0.36808117
75MAP3K30.35951898
76CAMK2G0.35679692
77TEC0.34071530
78PDGFRA0.33659047
79RET0.32629791
80CAMK2B0.32114293
81TGFBR20.32066719
82FYN0.31024422
83JAK20.28264372
84BTK0.27821769
85PRKACA0.25921731
86MAPK130.25894084
87CSF1R0.25830583
88PTK20.25404572
89ADRBK20.25057525
90MAP3K110.23457652
91BCR0.23002898
92IGF1R0.20756769
93CDK190.20464870
94PRKCI0.20314542
95CAMK2A0.19406586
96KIT0.19165355
97SYK0.18475029
98IRAK20.18423943
99ERBB30.18195379
100IKBKE0.16775920

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004605.10928866
2Vitamin digestion and absorption_Homo sapiens_hsa049774.92509556
3Fat digestion and absorption_Homo sapiens_hsa049754.48492745
4Renin-angiotensin system_Homo sapiens_hsa046144.23587177
5Protein digestion and absorption_Homo sapiens_hsa049742.74083301
6Mineral absorption_Homo sapiens_hsa049782.64955493
7Caffeine metabolism_Homo sapiens_hsa002322.59537398
8Starch and sucrose metabolism_Homo sapiens_hsa005002.49481514
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.43958757
10Histidine metabolism_Homo sapiens_hsa003402.33045956
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.19341159
12Carbohydrate digestion and absorption_Homo sapiens_hsa049732.14915347
13Linoleic acid metabolism_Homo sapiens_hsa005912.02636345
14Arginine biosynthesis_Homo sapiens_hsa002202.02360594
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.96427628
16Galactose metabolism_Homo sapiens_hsa000521.95623586
17Chemical carcinogenesis_Homo sapiens_hsa052041.93554532
18Retinol metabolism_Homo sapiens_hsa008301.90517801
19Drug metabolism - other enzymes_Homo sapiens_hsa009831.87528112
20Fructose and mannose metabolism_Homo sapiens_hsa000511.84971232
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.82651679
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.74389687
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.70598375
24PPAR signaling pathway_Homo sapiens_hsa033201.69330155
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.63346056
26Bile secretion_Homo sapiens_hsa049761.62496635
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.58260775
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.52711043
29Arachidonic acid metabolism_Homo sapiens_hsa005901.47805399
30Sulfur metabolism_Homo sapiens_hsa009201.47017944
31Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.38551355
32Glycerolipid metabolism_Homo sapiens_hsa005611.36385807
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.35700354
34Arginine and proline metabolism_Homo sapiens_hsa003301.32748396
35Tryptophan metabolism_Homo sapiens_hsa003801.23871117
36Fatty acid degradation_Homo sapiens_hsa000711.11543884
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.08286886
38Asthma_Homo sapiens_hsa053101.07335604
39Ether lipid metabolism_Homo sapiens_hsa005651.04194374
40Sphingolipid metabolism_Homo sapiens_hsa006001.03160296
41Phenylalanine metabolism_Homo sapiens_hsa003600.96043884
42Intestinal immune network for IgA production_Homo sapiens_hsa046720.91681143
43Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87065308
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79482477
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.76495881
46Glutathione metabolism_Homo sapiens_hsa004800.73230163
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70642165
48Glycerophospholipid metabolism_Homo sapiens_hsa005640.65108827
49Allograft rejection_Homo sapiens_hsa053300.65086274
50Pancreatic secretion_Homo sapiens_hsa049720.61717162
51Folate biosynthesis_Homo sapiens_hsa007900.61553007
52Autoimmune thyroid disease_Homo sapiens_hsa053200.60384148
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59233170
54Graft-versus-host disease_Homo sapiens_hsa053320.56906158
55Fatty acid metabolism_Homo sapiens_hsa012120.52138755
56Fatty acid biosynthesis_Homo sapiens_hsa000610.50526535
57Peroxisome_Homo sapiens_hsa041460.49383175
58Staphylococcus aureus infection_Homo sapiens_hsa051500.48343983
59Type I diabetes mellitus_Homo sapiens_hsa049400.44989145
60ABC transporters_Homo sapiens_hsa020100.43143328
61Renin secretion_Homo sapiens_hsa049240.40627639
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.36249572
63Tyrosine metabolism_Homo sapiens_hsa003500.35731328
64Other glycan degradation_Homo sapiens_hsa005110.34036648
65Insulin resistance_Homo sapiens_hsa049310.33853326
66Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.28701926
67Thyroid hormone synthesis_Homo sapiens_hsa049180.28658600
68Insulin secretion_Homo sapiens_hsa049110.26945871
69Glucagon signaling pathway_Homo sapiens_hsa049220.24464005
70Pentose phosphate pathway_Homo sapiens_hsa000300.24363432
71Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.24061676
72Cocaine addiction_Homo sapiens_hsa050300.23705655
73Metabolic pathways_Homo sapiens_hsa011000.23231151
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.22850032
75Antigen processing and presentation_Homo sapiens_hsa046120.19525485
76Butanoate metabolism_Homo sapiens_hsa006500.15609952
77Serotonergic synapse_Homo sapiens_hsa047260.13953370
78Amphetamine addiction_Homo sapiens_hsa050310.13126774
79Pyruvate metabolism_Homo sapiens_hsa006200.13067415
80Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.12540138
81Viral myocarditis_Homo sapiens_hsa054160.11560559
82Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.10345144
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.08622144
84Leishmaniasis_Homo sapiens_hsa051400.07928942
85Biosynthesis of amino acids_Homo sapiens_hsa012300.07086360
86Propanoate metabolism_Homo sapiens_hsa006400.06615914
87Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.06417275
88Sulfur relay system_Homo sapiens_hsa041220.04959002
89Hepatitis C_Homo sapiens_hsa051600.03495800
90Tight junction_Homo sapiens_hsa045300.03401165
91Aldosterone synthesis and secretion_Homo sapiens_hsa049250.03193119
92Carbon metabolism_Homo sapiens_hsa012000.01682748
93Fatty acid elongation_Homo sapiens_hsa000620.01346870
94beta-Alanine metabolism_Homo sapiens_hsa004100.01346505
95Pertussis_Homo sapiens_hsa051330.01308756
96Hematopoietic cell lineage_Homo sapiens_hsa046400.00189519
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514-0.0172014
98African trypanosomiasis_Homo sapiens_hsa05143-0.0142260
99AMPK signaling pathway_Homo sapiens_hsa04152-0.0021152
100Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0012338

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