C17ORF64

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1male meiosis I (GO:0007141)9.98573155
2chromosome organization involved in meiosis (GO:0070192)8.75087150
3male meiosis (GO:0007140)8.71439223
4DNA methylation involved in gamete generation (GO:0043046)8.55175866
5acrosome reaction (GO:0007340)8.24462491
6sperm motility (GO:0030317)8.18255411
7meiosis I (GO:0007127)7.87567528
8synaptonemal complex assembly (GO:0007130)7.75562533
9meiotic nuclear division (GO:0007126)7.41947405
10chromosome condensation (GO:0030261)7.24373609
11DNA packaging (GO:0006323)7.23347512
12synaptonemal complex organization (GO:0070193)6.99518402
13fusion of sperm to egg plasma membrane (GO:0007342)6.82227162
14histone H3-K9 demethylation (GO:0033169)6.64563305
15spermatid development (GO:0007286)6.62898984
16binding of sperm to zona pellucida (GO:0007339)6.52505231
17sister chromatid cohesion (GO:0007062)6.31853663
18sperm-egg recognition (GO:0035036)6.29498077
19positive regulation of meiosis (GO:0045836)6.20808514
20negative regulation of inclusion body assembly (GO:0090084)6.18437436
21single strand break repair (GO:0000012)6.04066294
22DNA synthesis involved in DNA repair (GO:0000731)5.88335046
23positive regulation of meiotic cell cycle (GO:0051446)5.82003629
24meiotic cell cycle process (GO:1903046)5.75109482
25spermatogenesis (GO:0007283)5.62767229
26protein targeting to Golgi (GO:0000042)5.62232884
27male gamete generation (GO:0048232)5.61212859
28microtubule severing (GO:0051013)5.52275806
29establishment of protein localization to Golgi (GO:0072600)5.44651504
30protein polyglutamylation (GO:0018095)5.43078552
31microtubule depolymerization (GO:0007019)5.29681514
32gamete generation (GO:0007276)5.27396916
33sperm capacitation (GO:0048240)5.25802062
34plasma membrane fusion (GO:0045026)5.12598148
35rRNA methylation (GO:0031167)5.12256257
36retrograde transport, vesicle recycling within Golgi (GO:0000301)5.10156905
37germ cell development (GO:0007281)5.08632082
38cell-cell recognition (GO:0009988)5.08000284
39negative regulation of meiosis (GO:0045835)4.95834721
40regulation of centriole replication (GO:0046599)4.95476313
41meiotic chromosome segregation (GO:0045132)4.93118746
42spermatid nucleus differentiation (GO:0007289)4.86202861
43histone H3-K36 demethylation (GO:0070544)4.85362639
44multicellular organism reproduction (GO:0032504)4.82627296
45centriole replication (GO:0007099)4.71208762
46sex differentiation (GO:0007548)4.65703510
47microtubule polymerization or depolymerization (GO:0031109)4.56715710
48fertilization (GO:0009566)4.55053143
49rRNA modification (GO:0000154)4.49847481
50oogenesis (GO:0048477)4.42214440
51reproduction (GO:0000003)4.41707469
52cellular process involved in reproduction in multicellular organism (GO:0022412)4.34704583
53protein localization to Golgi apparatus (GO:0034067)4.33550538
54regulation of cilium movement (GO:0003352)4.32704209
55response to pheromone (GO:0019236)4.29855537
56centriole assembly (GO:0098534)4.24727751
57calcium ion-dependent exocytosis (GO:0017156)4.23194495
58regulation of histone H3-K9 methylation (GO:0051570)4.22041247
59axonemal dynein complex assembly (GO:0070286)4.18306368
60multicellular organismal reproductive process (GO:0048609)4.17761272
61reciprocal meiotic recombination (GO:0007131)4.12440489
62reciprocal DNA recombination (GO:0035825)4.12440489
63negative regulation of gene silencing (GO:0060969)4.11384101
64male sex determination (GO:0030238)4.10289252
65female gamete generation (GO:0007292)4.01284959
66cilium or flagellum-dependent cell motility (GO:0001539)3.98861945
67regulation of inclusion body assembly (GO:0090083)3.96770442
68sexual reproduction (GO:0019953)3.95803735
69resolution of meiotic recombination intermediates (GO:0000712)3.90168646
70regulation of microtubule-based movement (GO:0060632)3.84588681
71phosphatidylethanolamine biosynthetic process (GO:0006646)3.82013694
72nuclear pore complex assembly (GO:0051292)3.81457906
73nucleus organization (GO:0006997)3.79980693
74mitotic sister chromatid cohesion (GO:0007064)3.75201184
75motile cilium assembly (GO:0044458)3.74315801
76seminiferous tubule development (GO:0072520)3.73999247
77single fertilization (GO:0007338)3.70070255
78gene silencing by RNA (GO:0031047)3.60229154
79regulation of meiotic cell cycle (GO:0051445)3.54460619
80phosphatidylethanolamine metabolic process (GO:0046337)3.53574569
81embryonic body morphogenesis (GO:0010172)3.52231680
82microtubule nucleation (GO:0007020)3.48257002
83DNA methylation (GO:0006306)3.44275404
84DNA alkylation (GO:0006305)3.44275404
85negative regulation of meiotic cell cycle (GO:0051447)3.38657224
86positive regulation of male gonad development (GO:2000020)3.38235906
87regulation of meiosis (GO:0040020)3.31147372
88oocyte development (GO:0048599)3.29484399
89gene silencing (GO:0016458)3.28003036
90histone exchange (GO:0043486)3.21745390
91response to acidic pH (GO:0010447)3.19021516
92epithelial cilium movement (GO:0003351)3.18927652
93Sertoli cell development (GO:0060009)3.14230623
94RNA destabilization (GO:0050779)3.08558083
95histone lysine demethylation (GO:0070076)3.08526149
96positive regulation of Rab GTPase activity (GO:0032851)3.05882948
97regulation of Rab GTPase activity (GO:0032313)3.05882948
98regulation of meiosis I (GO:0060631)10.9460866
99piRNA metabolic process (GO:0034587)10.5405796
100synapsis (GO:0007129)10.0678894

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat7.20587176
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.51222557
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.97417022
4MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.75761264
5ERA_21632823_ChIP-Seq_H3396_Human2.41552298
6FUS_26573619_Chip-Seq_HEK293_Human2.38004733
7MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.29793308
8VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.25501883
9CTBP1_25329375_ChIP-Seq_LNCAP_Human2.17103608
10TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.14282519
11POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.14282519
12BMI1_23680149_ChIP-Seq_NPCS_Mouse2.09640715
13YY1_22570637_ChIP-Seq_MALME-3M_Human2.06086827
14ER_23166858_ChIP-Seq_MCF-7_Human2.04310725
15IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.95523220
16CBP_20019798_ChIP-Seq_JUKART_Human1.95523220
17RNF2_27304074_Chip-Seq_NSC_Mouse1.94994736
18CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.90319258
19WDR5_24793694_ChIP-Seq_LNCAP_Human1.82896076
20RAC3_21632823_ChIP-Seq_H3396_Human1.80961899
21ELF1_20517297_ChIP-Seq_JURKAT_Human1.78495027
22CTBP2_25329375_ChIP-Seq_LNCAP_Human1.74025304
23RUNX1_26923725_Chip-Seq_HPCs_Mouse1.73226087
24ZNF274_21170338_ChIP-Seq_K562_Hela1.71441808
25UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.71396999
26EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.70903349
27TDRD3_21172665_ChIP-Seq_MCF-7_Human1.67390517
28SMC4_20622854_ChIP-Seq_HELA_Human1.65424763
29TP63_19390658_ChIP-ChIP_HaCaT_Human1.64340167
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64115520
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.63107891
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62752439
33P68_20966046_ChIP-Seq_HELA_Human1.62059109
34EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.57325818
35FOXH1_21741376_ChIP-Seq_EPCs_Human1.56769654
36PHF8_20622854_ChIP-Seq_HELA_Human1.54387513
37SMAD4_21741376_ChIP-Seq_EPCs_Human1.53938315
38SALL1_21062744_ChIP-ChIP_HESCs_Human1.51814038
39RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.50345802
40* MYC_19829295_ChIP-Seq_ESCs_Human1.50253349
41E2F1_20622854_ChIP-Seq_HELA_Human1.50210129
42RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.47793115
43BCL6_27268052_Chip-Seq_Bcells_Human1.46074789
44OCT4_20526341_ChIP-Seq_ESCs_Human1.43596438
45KLF5_20875108_ChIP-Seq_MESCs_Mouse1.40364264
46BCOR_27268052_Chip-Seq_Bcells_Human1.38312356
47ETV1_20927104_ChIP-Seq_GIST48_Human1.37305344
48P300_27268052_Chip-Seq_Bcells_Human1.35735420
49TAF15_26573619_Chip-Seq_HEK293_Human1.35402544
50NANOG_20526341_ChIP-Seq_ESCs_Human1.34686775
51TAF2_19829295_ChIP-Seq_ESCs_Human1.33792545
52HOXB7_26014856_ChIP-Seq_BT474_Human1.33641789
53CBX2_22325352_ChIP-Seq_293T-Rex_Human1.31444478
54AR_25329375_ChIP-Seq_VCAP_Human1.29634849
55RUNX2_22187159_ChIP-Seq_PCA_Human1.29143255
56CTCF_27219007_Chip-Seq_Bcells_Human1.27297199
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25559494
58SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.24998532
59CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.24540747
60AUTS2_25519132_ChIP-Seq_293T-REX_Human1.23736335
61P300_19829295_ChIP-Seq_ESCs_Human1.23125848
62SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.22524855
63RBPJ_21746931_ChIP-Seq_IB4_Human1.21845484
64PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.21527782
65CBX2_27304074_Chip-Seq_ESCs_Mouse1.20973601
66* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.20833247
67HNFA_21074721_ChIP-Seq_CACO-2_Human1.20579318
68GATA3_26560356_Chip-Seq_TH1_Human1.15395856
69PHF8_20622853_ChIP-Seq_HELA_Human1.14711588
70GATA3_21878914_ChIP-Seq_MCF-7_Human1.14489927
71E2F1_17053090_ChIP-ChIP_MCF-7_Human1.13829427
72IGF1R_20145208_ChIP-Seq_DFB_Human1.13529682
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12845332
74CTCF_20526341_ChIP-Seq_ESCs_Human1.11848970
75HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.11476081
76ERG_20517297_ChIP-Seq_VCAP_Human1.10551996
77SMAD3_21741376_ChIP-Seq_ESCs_Human1.10213030
78PKCTHETA_26484144_Chip-Seq_BREAST_Human1.08495661
79TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.08490776
80STAT3_23295773_ChIP-Seq_U87_Human1.08209017
81NFYB_21822215_ChIP-Seq_K562_Human1.07759379
82PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.07548896
83TBL1_22424771_ChIP-Seq_293T_Human1.07256316
84ETV2_25802403_ChIP-Seq_MESCs_Mouse1.07101595
85SMAD3_21741376_ChIP-Seq_EPCs_Human1.06608123
86PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.06521587
87OCT4_19829295_ChIP-Seq_ESCs_Human1.05720057
88BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human1.04763780
89SMRT_27268052_Chip-Seq_Bcells_Human1.04513128
90TP63_22573176_ChIP-Seq_HFKS_Human1.03225633
91E2F7_22180533_ChIP-Seq_HELA_Human1.02957998
92SOX11_22085726_ChIP-Seq_ESNs_Mouse1.02861304
93SOX2_22085726_ChIP-Seq_NPCs_Mouse1.02414004
94CEBPB_22108803_ChIP-Seq_LS180_Human1.02091441
95ARNT_22903824_ChIP-Seq_MCF-7_Human1.00024340
96FOXA1_25329375_ChIP-Seq_VCAP_Human0.99089946
97FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99089946
98TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98492252
99GATA6_21074721_ChIP-Seq_CACO-2_Human0.97837468
100KLF4_19829295_ChIP-Seq_ESCs_Human0.97683069

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization8.66765167
2MP0008877_abnormal_DNA_methylation7.06666203
3MP0001929_abnormal_gametogenesis5.04185174
4MP0003698_abnormal_male_reproductive4.93605739
5MP0002210_abnormal_sex_determination4.29600677
6MP0001145_abnormal_male_reproductive3.26444082
7MP0003878_abnormal_ear_physiology3.10290032
8MP0005377_hearing/vestibular/ear_phenot3.10290032
9MP0000653_abnormal_sex_gland3.00599062
10MP0002161_abnormal_fertility/fecundity2.67412517
11MP0000678_abnormal_parathyroid_gland2.65839505
12MP0005670_abnormal_white_adipose2.64173926
13MP0001348_abnormal_lacrimal_gland2.55803141
14MP0003646_muscle_fatigue2.40988184
15MP0002160_abnormal_reproductive_system2.33187754
16MP0008058_abnormal_DNA_repair1.94191127
17MP0000015_abnormal_ear_pigmentation1.80548354
18MP0002254_reproductive_system_inflammat1.75217431
19MP0008004_abnormal_stomach_pH1.68263664
20MP0000569_abnormal_digit_pigmentation1.67365338
21MP0008995_early_reproductive_senescence1.60379666
22MP0005310_abnormal_salivary_gland1.53957665
23MP0003718_maternal_effect1.53029442
24MP0005389_reproductive_system_phenotype1.48311260
25MP0005174_abnormal_tail_pigmentation1.47750865
26MP0005409_darkened_coat_color1.41899344
27MP0001119_abnormal_female_reproductive1.36529030
28MP0000383_abnormal_hair_follicle1.30789227
29MP0003693_abnormal_embryo_hatching1.27751618
30MP0005666_abnormal_adipose_tissue1.25695247
31MP0000427_abnormal_hair_cycle1.20590406
32MP0003011_delayed_dark_adaptation1.18264061
33MP0003936_abnormal_reproductive_system1.16636749
34MP0004742_abnormal_vestibular_system1.15028570
35MP0001486_abnormal_startle_reflex1.11386442
36MP0003699_abnormal_female_reproductive1.09983998
37MP0003077_abnormal_cell_cycle1.08092146
38MP0002249_abnormal_larynx_morphology1.06469700
39MP0008789_abnormal_olfactory_epithelium1.05382135
40MP0004233_abnormal_muscle_weight1.00828017
41MP0006276_abnormal_autonomic_nervous1.00458026
42MP0003119_abnormal_digestive_system0.97283318
43MP0005423_abnormal_somatic_nervous0.95972081
44MP0001984_abnormal_olfaction0.94161650
45MP0002282_abnormal_trachea_morphology0.93917620
46MP0001485_abnormal_pinna_reflex0.93053283
47MP0002132_abnormal_respiratory_system0.92427599
48MP0002184_abnormal_innervation0.91162764
49MP0005167_abnormal_blood-brain_barrier0.90921089
50MP0005379_endocrine/exocrine_gland_phen0.88988868
51MP0005645_abnormal_hypothalamus_physiol0.87006627
52MP0002653_abnormal_ependyma_morphology0.86920071
53MP0005394_taste/olfaction_phenotype0.86611651
54MP0005499_abnormal_olfactory_system0.86611651
55MP0005551_abnormal_eye_electrophysiolog0.75185056
56MP0008007_abnormal_cellular_replicative0.74192632
57MP0009053_abnormal_anal_canal0.70807908
58MP0005375_adipose_tissue_phenotype0.70561693
59MP0005451_abnormal_body_composition0.69187851
60MP0001963_abnormal_hearing_physiology0.68966916
61MP0009115_abnormal_fat_cell0.67387754
62MP0000955_abnormal_spinal_cord0.66734263
63MP0001968_abnormal_touch/_nociception0.66691705
64MP0006035_abnormal_mitochondrial_morpho0.66116320
65MP0003879_abnormal_hair_cell0.64627778
66MP0002229_neurodegeneration0.64533872
67MP0005647_abnormal_sex_gland0.64511920
68MP0010678_abnormal_skin_adnexa0.63727846
69MP0002735_abnormal_chemical_nociception0.62604167
70MP0002971_abnormal_brown_adipose0.61734096
71MP0002067_abnormal_sensory_capabilities0.61195001
72MP0001919_abnormal_reproductive_system0.60731859
73MP0008057_abnormal_DNA_replication0.59320108
74MP0002127_abnormal_cardiovascular_syste0.59061015
75MP0002095_abnormal_skin_pigmentation0.57657987
76MP0010386_abnormal_urinary_bladder0.53386957
77MP0002138_abnormal_hepatobiliary_system0.53364617
78MP0005253_abnormal_eye_physiology0.53342008
79MP0010094_abnormal_chromosome_stability0.53260535
80MP0001765_abnormal_ion_homeostasis0.50336047
81MP0000026_abnormal_inner_ear0.48916129
82MP0001661_extended_life_span0.47230135
83MP0000470_abnormal_stomach_morphology0.46425252
84MP0006292_abnormal_olfactory_placode0.45315856
85MP0000681_abnormal_thyroid_gland0.43623639
86MP0003861_abnormal_nervous_system0.43303561
87MP0004811_abnormal_neuron_physiology0.42772588
88MP0002882_abnormal_neuron_morphology0.41613737
89MP0004264_abnormal_extraembryonic_tissu0.40975779
90MP0002084_abnormal_developmental_patter0.40472454
91MP0005535_abnormal_body_temperature0.39608114
92MP0005058_abnormal_lysosome_morphology0.39561638
93MP0003943_abnormal_hepatobiliary_system0.39521992
94MP0004019_abnormal_vitamin_homeostasis0.38499704
95MP0003172_abnormal_lysosome_physiology0.38241392
96MP0010307_abnormal_tumor_latency0.38142195
97MP0009046_muscle_twitch0.37515646
98MP0001188_hyperpigmentation0.37003565
99MP0002932_abnormal_joint_morphology0.36629037
100MP0004036_abnormal_muscle_relaxation0.36402376

Predicted human phenotypes

RankGene SetZ-score
1Tubulointerstitial nephritis (HP:0001970)5.33034865
2Severe visual impairment (HP:0001141)5.17718041
3Osteomalacia (HP:0002749)4.42149713
4Degeneration of the lateral corticospinal tracts (HP:0002314)4.33566700
5Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.33566700
6Neonatal short-limb short stature (HP:0008921)4.24099100
7Absent/shortened dynein arms (HP:0200106)4.01396761
8Dynein arm defect of respiratory motile cilia (HP:0012255)4.01396761
9Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.74734656
10Horizontal nystagmus (HP:0000666)3.67845775
11Oligodactyly (hands) (HP:0001180)3.66783100
12Upper motor neuron abnormality (HP:0002127)3.62518729
13Chronic hepatic failure (HP:0100626)3.61351931
14Abnormality of macular pigmentation (HP:0008002)3.61296870
15Abnormality of the lower motor neuron (HP:0002366)3.59097999
16Abnormality of the corticospinal tract (HP:0002492)3.58039098
17Volvulus (HP:0002580)3.50751287
18Resting tremor (HP:0002322)3.50193581
19Abnormal respiratory motile cilium physiology (HP:0012261)3.42454958
20Amyotrophic lateral sclerosis (HP:0007354)3.37791775
21Azoospermia (HP:0000027)3.34219810
22Infertility (HP:0000789)3.30044147
23Aplasia/Hypoplasia of the earlobes (HP:0009906)3.25554103
24Nephronophthisis (HP:0000090)3.22644390
25Abnormal ciliary motility (HP:0012262)3.14281922
26Rimmed vacuoles (HP:0003805)3.12952446
27Shoulder girdle muscle weakness (HP:0003547)3.11835300
28Bony spicule pigmentary retinopathy (HP:0007737)3.10383357
29Truncal obesity (HP:0001956)3.08311937
30Natal tooth (HP:0000695)3.07833769
31Hyperkalemia (HP:0002153)3.00440926
32Asymmetric septal hypertrophy (HP:0001670)2.99874124
33Impaired vibration sensation in the lower limbs (HP:0002166)2.99217770
34Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.96797229
35Abnormal spermatogenesis (HP:0008669)2.91487723
36Gonadotropin excess (HP:0000837)2.86319994
37Stage 5 chronic kidney disease (HP:0003774)2.85111646
38Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.81766812
39Abnormality of the renal medulla (HP:0100957)2.79854682
40Abnormal respiratory epithelium morphology (HP:0012253)2.77324957
41Abnormal respiratory motile cilium morphology (HP:0005938)2.77324957
42Attenuation of retinal blood vessels (HP:0007843)2.76174167
43Male infertility (HP:0003251)2.71633691
44Tubulointerstitial abnormality (HP:0001969)2.68484315
45Nasal polyposis (HP:0100582)2.64345730
46Menstrual irregularities (HP:0000858)2.61747763
47Facial cleft (HP:0002006)2.59797178
48Bell-shaped thorax (HP:0001591)2.52621119
49Scotoma (HP:0000575)2.49568845
50Sensory axonal neuropathy (HP:0003390)2.42510287
51Synostosis of carpal bones (HP:0005048)2.38879498
52Intellectual disability, moderate (HP:0002342)2.35989576
53Oligodactyly (HP:0012165)2.31164107
54Tubular atrophy (HP:0000092)2.29244608
55Type I transferrin isoform profile (HP:0003642)2.26984344
56Amelogenesis imperfecta (HP:0000705)2.26372112
57Progressive sensorineural hearing impairment (HP:0000408)2.20975649
58Cone-rod dystrophy (HP:0000548)2.20261623
59Abnormal rod and cone electroretinograms (HP:0008323)2.18016306
60Supernumerary spleens (HP:0009799)2.16755216
61Impulsivity (HP:0100710)2.13407715
62Abnormality of the nasal mucosa (HP:0000433)2.11137960
63Enlarged epiphyses (HP:0010580)2.10141273
64Abnormality of dental color (HP:0011073)2.05940509
65Abnormal glycosylation (HP:0012345)2.05043603
66Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.05043603
67Abnormal protein N-linked glycosylation (HP:0012347)2.05043603
68Abnormal protein glycosylation (HP:0012346)2.05043603
69Chromosomal breakage induced by crosslinking agents (HP:0003221)2.02454873
70Small intestinal stenosis (HP:0012848)2.02050578
71Duodenal stenosis (HP:0100867)2.02050578
72Spontaneous abortion (HP:0005268)2.01704404
73Impaired vibratory sensation (HP:0002495)1.98407294
74Increased purine levels (HP:0004368)1.95125117
75Hyperuricemia (HP:0002149)1.95125117
76Atelectasis (HP:0100750)1.95020211
77Hand muscle atrophy (HP:0009130)1.94307559
78Short nail (HP:0001799)1.93708870
79Atrophy/Degeneration involving motor neurons (HP:0007373)1.92470094
80Complete atrioventricular canal defect (HP:0001674)1.92129981
81Postural instability (HP:0002172)1.91254225
82Insulin-resistant diabetes mellitus (HP:0000831)1.90953275
83Abnormality of renal excretion (HP:0011036)1.89443713
84Occipital encephalocele (HP:0002085)1.88738363
85Abnormality of DNA repair (HP:0003254)1.88351182
86Urinary bladder sphincter dysfunction (HP:0002839)1.88140318
87Ectopic kidney (HP:0000086)1.88108334
88Facial hemangioma (HP:0000329)1.87642160
89Abnormal drinking behavior (HP:0030082)1.87499604
90Polydipsia (HP:0001959)1.87499604
91Progressive cerebellar ataxia (HP:0002073)1.86588846
92Double outlet right ventricle (HP:0001719)1.85713121
93Congenital malformation of the right heart (HP:0011723)1.85713121
94Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.85001743
95Urinary urgency (HP:0000012)1.84915296
96Rhinitis (HP:0012384)1.83651814
97Abnormal urine output (HP:0012590)1.81165064
98Male pseudohermaphroditism (HP:0000037)1.74711282
99Chronic bronchitis (HP:0004469)1.74124094
100Buphthalmos (HP:0000557)1.73155401

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK9.79526294
2PLK46.37620921
3CAMK1G4.12404912
4CDK193.53627725
5MET3.33359596
6INSRR2.69657230
7PTK2B2.58102133
8PLK22.50855206
9TESK12.16827753
10BMX1.94606276
11PDK21.84766244
12BRD41.82997952
13STK381.63876833
14FGR1.54912250
15MST1R1.54110208
16CSF1R1.47859503
17OXSR11.32044719
18DDR21.31436675
19STK38L1.30872717
20PDPK11.27519369
21PDK11.25431867
22PINK11.25239219
23WNK11.15028231
24MAP4K21.10298043
25TYRO31.07749393
26MAP3K111.06673482
27PIK3CG1.03626679
28BRAF1.02635782
29LATS10.94634697
30PDGFRB0.89878768
31ACVR1B0.85494054
32MINK10.83339779
33NEK60.81647129
34MAP2K20.76862546
35BMPR1B0.73712977
36CHEK10.71612660
37CAMK10.71379573
38MAP3K100.69050415
39PLK10.68768656
40CDK70.66034876
41MARK30.63536055
42RET0.63186839
43CDK40.62570303
44TLK10.59002770
45MAP3K90.56894282
46PASK0.55221256
47PRKD30.53210643
48ZAK0.52826567
49MAP3K40.52385156
50SGK10.51342154
51MAP3K20.51044661
52CDK30.49742892
53NTRK30.48195622
54RPS6KA10.46879684
55MAPK150.45490702
56DYRK1B0.45301561
57RPS6KA20.44971894
58PRKG10.42154510
59CDK10.38728331
60ATR0.35516995
61CDK20.35417748
62BRSK10.34852006
63WEE10.33591516
64MAPK10.32184273
65ATM0.31647956
66ROCK10.30640895
67MTOR0.30474952
68AURKA0.30387950
69YES10.29412847
70RPS6KA60.29079344
71EGFR0.28982645
72KSR20.27334426
73RPS6KL10.26376204
74RPS6KC10.26376204
75GSK3B0.25404120
76TNK20.25395011
77TTK0.24682286
78DYRK20.24088989
79MAP3K130.23288602
80CSNK1E0.22977787
81DYRK30.22705703
82CASK0.22242936
83ARAF0.21169072
84CDK11A0.19880894
85AKT20.19373545
86STK110.19177440
87MAPK140.18711881
88LATS20.18565635
89CDK90.18358125
90PRKCI0.18035318
91CDK120.17426246
92RPS6KB10.16317574
93MAP3K10.16167841
94TIE10.15648574
95NEK20.15630629
96CDK50.12177176
97STK160.11981407
98PRKCZ0.11763046
99PRKCG0.11671839
100CDK60.11447055

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.64682005
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.46027430
3RNA transport_Homo sapiens_hsa030134.27975386
4Homologous recombination_Homo sapiens_hsa034403.71037879
5Olfactory transduction_Homo sapiens_hsa047403.45714878
6Fanconi anemia pathway_Homo sapiens_hsa034603.16528759
7Dorso-ventral axis formation_Homo sapiens_hsa043202.85390345
8Oocyte meiosis_Homo sapiens_hsa041142.64526674
9Ubiquitin mediated proteolysis_Homo sapiens_hsa041202.42146566
10Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.37893458
11mRNA surveillance pathway_Homo sapiens_hsa030152.37232228
12Base excision repair_Homo sapiens_hsa034102.06583420
13Sulfur relay system_Homo sapiens_hsa041222.03887003
14DNA replication_Homo sapiens_hsa030301.92907408
15Mismatch repair_Homo sapiens_hsa034301.92854897
16Cell cycle_Homo sapiens_hsa041101.88600567
17Regulation of autophagy_Homo sapiens_hsa041401.73132484
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.70374450
19Glycerophospholipid metabolism_Homo sapiens_hsa005641.64464393
20Antigen processing and presentation_Homo sapiens_hsa046121.62459313
21RNA degradation_Homo sapiens_hsa030181.58186805
22Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.52134800
23Fatty acid metabolism_Homo sapiens_hsa012121.51888160
24Butanoate metabolism_Homo sapiens_hsa006501.48640328
25Nucleotide excision repair_Homo sapiens_hsa034201.36710941
26Fatty acid degradation_Homo sapiens_hsa000711.36348928
27Basal transcription factors_Homo sapiens_hsa030221.32156545
28Phenylalanine metabolism_Homo sapiens_hsa003601.29465878
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.09835078
30Taste transduction_Homo sapiens_hsa047421.07849365
31ErbB signaling pathway_Homo sapiens_hsa040121.07179587
32Type II diabetes mellitus_Homo sapiens_hsa049301.05587728
33Allograft rejection_Homo sapiens_hsa053301.04045500
34Viral myocarditis_Homo sapiens_hsa054161.02056784
35Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.95771977
36Autoimmune thyroid disease_Homo sapiens_hsa053200.94643236
37Graft-versus-host disease_Homo sapiens_hsa053320.90570490
38Calcium signaling pathway_Homo sapiens_hsa040200.89566913
39Endocytosis_Homo sapiens_hsa041440.88253533
40VEGF signaling pathway_Homo sapiens_hsa043700.88023834
41Lysine degradation_Homo sapiens_hsa003100.87762124
42beta-Alanine metabolism_Homo sapiens_hsa004100.87381716
43Fatty acid elongation_Homo sapiens_hsa000620.84095206
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83420167
45Propanoate metabolism_Homo sapiens_hsa006400.82389072
46Phototransduction_Homo sapiens_hsa047440.80987945
47Selenocompound metabolism_Homo sapiens_hsa004500.80708021
48Adipocytokine signaling pathway_Homo sapiens_hsa049200.79957953
49Huntingtons disease_Homo sapiens_hsa050160.79831298
50MAPK signaling pathway_Homo sapiens_hsa040100.78805515
51ABC transporters_Homo sapiens_hsa020100.78649394
52Type I diabetes mellitus_Homo sapiens_hsa049400.77770012
53Influenza A_Homo sapiens_hsa051640.77611677
54Inositol phosphate metabolism_Homo sapiens_hsa005620.66259281
55N-Glycan biosynthesis_Homo sapiens_hsa005100.65341493
56Retinol metabolism_Homo sapiens_hsa008300.64502381
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61507303
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59893230
59Glycerolipid metabolism_Homo sapiens_hsa005610.58983925
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.58953785
61PPAR signaling pathway_Homo sapiens_hsa033200.56841320
62Hedgehog signaling pathway_Homo sapiens_hsa043400.54319772
63Synaptic vesicle cycle_Homo sapiens_hsa047210.52973085
64Acute myeloid leukemia_Homo sapiens_hsa052210.47511219
65Tyrosine metabolism_Homo sapiens_hsa003500.46187451
66Cardiac muscle contraction_Homo sapiens_hsa042600.45986400
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45615267
68Legionellosis_Homo sapiens_hsa051340.45401387
69Choline metabolism in cancer_Homo sapiens_hsa052310.44036344
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43747264
71Arginine and proline metabolism_Homo sapiens_hsa003300.41478813
72Protein digestion and absorption_Homo sapiens_hsa049740.40891910
73Estrogen signaling pathway_Homo sapiens_hsa049150.40184959
74Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37697933
75Purine metabolism_Homo sapiens_hsa002300.36642760
76mTOR signaling pathway_Homo sapiens_hsa041500.36090523
77Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.35270516
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33131259
79Sphingolipid metabolism_Homo sapiens_hsa006000.31866117
80Gap junction_Homo sapiens_hsa045400.28466426
81Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.27898605
82Fat digestion and absorption_Homo sapiens_hsa049750.24226963
83Viral carcinogenesis_Homo sapiens_hsa052030.21554097
84Melanoma_Homo sapiens_hsa052180.21219633
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.19804145
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.18385714
87Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.17102076
88Linoleic acid metabolism_Homo sapiens_hsa005910.14431922
89Epstein-Barr virus infection_Homo sapiens_hsa051690.14057447
90RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.13140525
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.12628061
92Spliceosome_Homo sapiens_hsa030400.12402437
93Oxytocin signaling pathway_Homo sapiens_hsa049210.12230325
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.12082435
95Non-small cell lung cancer_Homo sapiens_hsa052230.11828500
96Systemic lupus erythematosus_Homo sapiens_hsa053220.10781828
97Herpes simplex infection_Homo sapiens_hsa051680.10692301
98T cell receptor signaling pathway_Homo sapiens_hsa046600.10575852
99Glutamatergic synapse_Homo sapiens_hsa047240.09595001
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.09388024

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