C17ORF51

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)5.86646404
2regulation of short-term neuronal synaptic plasticity (GO:0048172)4.87157843
3glutamate secretion (GO:0014047)4.77088363
4synaptic vesicle maturation (GO:0016188)4.65314473
5synaptic vesicle exocytosis (GO:0016079)3.93996107
6regulation of synaptic vesicle exocytosis (GO:2000300)3.48669765
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.47429735
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.45422999
9protein localization to synapse (GO:0035418)3.34577066
10postsynaptic membrane organization (GO:0001941)3.33359145
11positive regulation of synapse maturation (GO:0090129)3.32798485
12sodium ion export (GO:0071436)3.32615098
13locomotory exploration behavior (GO:0035641)3.25840847
14cellular potassium ion homeostasis (GO:0030007)3.24900572
15regulation of neuronal synaptic plasticity (GO:0048168)3.17894135
16amino acid import (GO:0043090)3.16661683
17regulation of synaptic vesicle transport (GO:1902803)3.13718130
18neurotransmitter secretion (GO:0007269)3.11115778
19membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.03523418
20negative regulation of synaptic transmission, GABAergic (GO:0032229)3.00778141
21synaptic vesicle endocytosis (GO:0048488)2.84014571
22exploration behavior (GO:0035640)2.83639573
23positive regulation of dendritic spine morphogenesis (GO:0061003)2.78502619
24cerebellar granule cell differentiation (GO:0021707)2.78100152
25regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.73229441
26regulation of long-term neuronal synaptic plasticity (GO:0048169)2.69765418
27ionotropic glutamate receptor signaling pathway (GO:0035235)2.69674779
28cellular protein complex localization (GO:0034629)2.68081964
29positive regulation of dendritic spine development (GO:0060999)2.64885392
30neurotransmitter-gated ion channel clustering (GO:0072578)2.61059785
31L-amino acid import (GO:0043092)2.59508457
32cerebellar Purkinje cell layer development (GO:0021680)2.59006834
33synaptic transmission, glutamatergic (GO:0035249)2.56868729
34layer formation in cerebral cortex (GO:0021819)2.56839977
35vocalization behavior (GO:0071625)2.50674755
36protein complex localization (GO:0031503)2.49685473
37regulation of synaptic plasticity (GO:0048167)2.48853870
38neuronal action potential propagation (GO:0019227)2.48324105
39embryonic skeletal joint morphogenesis (GO:0060272)2.46516626
40positive regulation of neurotransmitter transport (GO:0051590)2.46269976
41cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.46244229
42regulation of dendritic spine morphogenesis (GO:0061001)2.44634279
43cell migration in hindbrain (GO:0021535)2.42989212
44neuron-neuron synaptic transmission (GO:0007270)2.42738823
45regulation of synapse maturation (GO:0090128)2.40650236
46gamma-aminobutyric acid signaling pathway (GO:0007214)2.40118999
47neurotransmitter transport (GO:0006836)2.40050080
48mitotic sister chromatid cohesion (GO:0007064)2.39549485
49regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.38418523
50regulation of mammary gland epithelial cell proliferation (GO:0033599)2.37286393
51regulation of glutamate receptor signaling pathway (GO:1900449)2.36898974
52neuromuscular process controlling balance (GO:0050885)2.35944203
53regulation of neurotransmitter secretion (GO:0046928)2.35917492
54nuclear pore complex assembly (GO:0051292)2.35604600
55regulation of voltage-gated calcium channel activity (GO:1901385)2.34530183
56cell communication by electrical coupling (GO:0010644)2.33497251
57chemosensory behavior (GO:0007635)2.33217324
58regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.32911453
59regulation of excitatory postsynaptic membrane potential (GO:0060079)2.32141320
60behavioral response to cocaine (GO:0048148)2.31502458
61positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.30668910
62DNA unwinding involved in DNA replication (GO:0006268)2.29976186
63negative regulation of dendrite morphogenesis (GO:0050774)2.29810143
64mitotic chromosome condensation (GO:0007076)2.26900393
65positive regulation of neurotransmitter secretion (GO:0001956)2.26706544
66neuron cell-cell adhesion (GO:0007158)2.26471188
67positive regulation of membrane potential (GO:0045838)2.25722356
68cytoskeletal anchoring at plasma membrane (GO:0007016)2.25409589
69nuclear pore organization (GO:0006999)2.24300440
70glutamate receptor signaling pathway (GO:0007215)2.23879277
71regulation of synapse structural plasticity (GO:0051823)2.23697035
72regulation of mitotic spindle organization (GO:0060236)2.23450476
73regulation of dendritic spine development (GO:0060998)2.22760175
74regulation of neurotransmitter transport (GO:0051588)2.20341566
75regulation of translational fidelity (GO:0006450)2.19434930
76regulation of vesicle fusion (GO:0031338)2.18995724
77proximal/distal pattern formation (GO:0009954)2.17912012
78mating behavior (GO:0007617)2.15530509
79righting reflex (GO:0060013)2.14789793
80regulation of postsynaptic membrane potential (GO:0060078)2.14334181
81neuromuscular process (GO:0050905)2.12247475
82neuron recognition (GO:0008038)2.09702545
83neuronal ion channel clustering (GO:0045161)2.09385214
84mitotic sister chromatid segregation (GO:0000070)2.08214212
85axon cargo transport (GO:0008088)2.07677829
86paraxial mesoderm development (GO:0048339)2.06779049
87positive regulation of synapse assembly (GO:0051965)2.06341823
88dendritic spine organization (GO:0097061)2.05744069
89regulation of neurotransmitter levels (GO:0001505)2.04142110
90DNA replication checkpoint (GO:0000076)2.02586383
91myelination in peripheral nervous system (GO:0022011)2.02267593
92peripheral nervous system axon ensheathment (GO:0032292)2.02267593
93regulation of NFAT protein import into nucleus (GO:0051532)2.01868731
94presynaptic membrane assembly (GO:0097105)2.01052234
95axonal fasciculation (GO:0007413)2.00794513
96gamma-aminobutyric acid transport (GO:0015812)2.00574187
97regulation of synapse assembly (GO:0051963)2.00179538
98transmission of nerve impulse (GO:0019226)1.99210637
99membrane depolarization during action potential (GO:0086010)1.99060133
100regulation of synaptic transmission (GO:0050804)1.98407303

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.34022968
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.91491549
3EZH2_22144423_ChIP-Seq_EOC_Human3.75928144
4EZH2_27304074_Chip-Seq_ESCs_Mouse2.82341267
5FOXM1_23109430_ChIP-Seq_U2OS_Human2.79532416
6EED_16625203_ChIP-ChIP_MESCs_Mouse2.74308123
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.58286639
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.58286639
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.54954166
10EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.40881326
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.37391863
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.33366631
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.28138255
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.15907399
15RARB_27405468_Chip-Seq_BRAIN_Mouse2.08513333
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.03964160
17PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.03404838
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.98252196
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.96917648
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.91749791
21RNF2_27304074_Chip-Seq_ESCs_Mouse1.86748353
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.86380220
23BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.85341180
24REST_21632747_ChIP-Seq_MESCs_Mouse1.85306368
25CBX2_27304074_Chip-Seq_ESCs_Mouse1.79440899
26MTF2_20144788_ChIP-Seq_MESCs_Mouse1.76897314
27RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.74072882
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.73278867
29REST_18959480_ChIP-ChIP_MESCs_Mouse1.72830299
30THAP11_20581084_ChIP-Seq_MESCs_Mouse1.70849162
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.69288117
32SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.67261793
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.64841735
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.64667343
35PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.55955945
36SUZ12_27294783_Chip-Seq_ESCs_Mouse1.54606252
37TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.49560538
38RING1B_27294783_Chip-Seq_NPCs_Mouse1.49541021
39ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.43132594
40RNF2_27304074_Chip-Seq_NSC_Mouse1.40708099
41TP53_20018659_ChIP-ChIP_R1E_Mouse1.40640648
42WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.40212261
43MYC_18555785_ChIP-Seq_MESCs_Mouse1.35098608
44CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.31686374
45KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.31488404
46XRN2_22483619_ChIP-Seq_HELA_Human1.28853315
47KDM2B_26808549_Chip-Seq_K562_Human1.26569365
48ZFP281_27345836_Chip-Seq_ESCs_Mouse1.25944051
49AR_21909140_ChIP-Seq_LNCAP_Human1.25637121
50ZFP281_18757296_ChIP-ChIP_E14_Mouse1.24993401
51RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.23987159
52TET1_21490601_ChIP-Seq_MESCs_Mouse1.22549281
53RING1B_27294783_Chip-Seq_ESCs_Mouse1.16714489
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.16031895
55RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.11339292
56ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.10414217
57SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.10207448
58CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.09834028
59DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08590188
60GATA1_26923725_Chip-Seq_HPCs_Mouse1.08386188
61OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.07966729
62ERG_21242973_ChIP-ChIP_JURKAT_Human1.07772143
63CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.07069872
64TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.06996590
65SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.06858267
66DROSHA_22980978_ChIP-Seq_HELA_Human1.06558638
67CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.06340655
68DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.04690797
69SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.02177515
70EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00389293
71SOX9_26525672_Chip-Seq_HEART_Mouse0.99541291
72NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.99343789
73GBX2_23144817_ChIP-Seq_PC3_Human0.98144419
74FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.97528053
75THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97390715
76POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.97054671
77TTF2_22483619_ChIP-Seq_HELA_Human0.96690836
78CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94000452
79PKCTHETA_26484144_Chip-Seq_BREAST_Human0.89153065
80TRIM28_21343339_ChIP-Seq_HEK293_Human0.88419946
81AR_19668381_ChIP-Seq_PC3_Human0.88132593
82MYC_19079543_ChIP-ChIP_MESCs_Mouse0.86266834
83P300_27058665_Chip-Seq_ZR-75-30cells_Human0.86178985
84SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.85932525
85E2F1_21310950_ChIP-Seq_MCF-7_Human0.85838115
86DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.85154228
87* CTBP2_25329375_ChIP-Seq_LNCAP_Human0.84314185
88FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.83994830
89TP53_23651856_ChIP-Seq_MEFs_Mouse0.82055118
90POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.81035953
91YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.78710945
92SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.77960594
93CTCF_27219007_Chip-Seq_Bcells_Human0.77291851
94RUNX1_26923725_Chip-Seq_HPCs_Mouse0.77146935
95CTNNB1_20460455_ChIP-Seq_HCT116_Human0.76609118
96NR3C1_23031785_ChIP-Seq_PC12_Mouse0.76421592
97UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.76033552
98YAP1_20516196_ChIP-Seq_MESCs_Mouse0.75996151
99E2F4_17652178_ChIP-ChIP_JURKAT_Human0.75281852
100YY1_21170310_ChIP-Seq_MESCs_Mouse0.75062698

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.26356356
2MP0005623_abnormal_meninges_morphology3.26311438
3MP0003880_abnormal_central_pattern2.66534227
4MP0004270_analgesia2.66000088
5MP0003635_abnormal_synaptic_transmissio2.46168703
6MP0002064_seizures2.18891485
7MP0005423_abnormal_somatic_nervous2.12100182
8MP0009046_muscle_twitch2.07930952
9MP0002063_abnormal_learning/memory/cond1.96282385
10MP0009745_abnormal_behavioral_response1.93277997
11MP0002734_abnormal_mechanical_nocicepti1.82852934
12MP0001346_abnormal_lacrimal_gland1.74575116
13MP0002272_abnormal_nervous_system1.67140840
14MP0005187_abnormal_penis_morphology1.65723745
15MP0004233_abnormal_muscle_weight1.61702377
16MP0001486_abnormal_startle_reflex1.60203715
17MP0003705_abnormal_hypodermis_morpholog1.59663248
18MP0002249_abnormal_larynx_morphology1.59563697
19MP0001968_abnormal_touch/_nociception1.59263112
20MP0002572_abnormal_emotion/affect_behav1.58734606
21MP0000537_abnormal_urethra_morphology1.54938171
22MP0000778_abnormal_nervous_system1.52827276
23MP0009053_abnormal_anal_canal1.49588850
24MP0002234_abnormal_pharynx_morphology1.48554464
25MP0010030_abnormal_orbit_morphology1.46543781
26MP0003111_abnormal_nucleus_morphology1.44220615
27MP0004811_abnormal_neuron_physiology1.40243310
28MP0000534_abnormal_ureter_morphology1.32290526
29MP0003385_abnormal_body_wall1.31788285
30MP0000751_myopathy1.30766775
31MP0009780_abnormal_chondrocyte_physiolo1.27353176
32MP0001299_abnormal_eye_distance/1.27300765
33MP0000955_abnormal_spinal_cord1.27089612
34MP0002735_abnormal_chemical_nociception1.26090760
35MP0009250_abnormal_appendicular_skeleto1.24320745
36MP0002736_abnormal_nociception_after1.21736619
37MP0010094_abnormal_chromosome_stability1.19736329
38MP0003942_abnormal_urinary_system1.18469632
39MP0008569_lethality_at_weaning1.13794776
40MP0003879_abnormal_hair_cell1.13694167
41MP0002184_abnormal_innervation1.11966925
42MP0003861_abnormal_nervous_system1.10634635
43MP0003937_abnormal_limbs/digits/tail_de1.10253830
44MP0003283_abnormal_digestive_organ1.10097611
45MP0008438_abnormal_cutaneous_collagen1.09000551
46MP0003123_paternal_imprinting1.08911969
47MP0002882_abnormal_neuron_morphology1.07621014
48MP0003693_abnormal_embryo_hatching1.06256049
49MP0005503_abnormal_tendon_morphology1.06149616
50MP0003329_amyloid_beta_deposits1.06127439
51MP0002067_abnormal_sensory_capabilities1.05762921
52MP0001502_abnormal_circadian_rhythm1.05709525
53MP0000049_abnormal_middle_ear1.05696883
54MP0002152_abnormal_brain_morphology1.04729267
55MP0002160_abnormal_reproductive_system1.01823588
56MP0005171_absent_coat_pigmentation1.01318209
57MP0002066_abnormal_motor_capabilities/c1.01276749
58MP0008932_abnormal_embryonic_tissue0.98116191
59MP0003077_abnormal_cell_cycle0.97647738
60MP0002557_abnormal_social/conspecific_i0.95631655
61MP0001970_abnormal_pain_threshold0.95281421
62MP0008058_abnormal_DNA_repair0.93734046
63MP0000733_abnormal_muscle_development0.92836497
64MP0005409_darkened_coat_color0.89794789
65MP0003119_abnormal_digestive_system0.89066660
66MP0004272_abnormal_basement_membrane0.88491235
67MP0001177_atelectasis0.88074335
68MP0004924_abnormal_behavior0.86282191
69MP0005386_behavior/neurological_phenoty0.86282191
70MP0001501_abnormal_sleep_pattern0.86185003
71MP0000749_muscle_degeneration0.85393170
72MP0002733_abnormal_thermal_nociception0.85017569
73MP0001529_abnormal_vocalization0.84918380
74MP0006276_abnormal_autonomic_nervous0.84913838
75MP0002233_abnormal_nose_morphology0.84275898
76MP0001440_abnormal_grooming_behavior0.84038890
77MP0010368_abnormal_lymphatic_system0.84023698
78MP0003136_yellow_coat_color0.83043364
79MP0001188_hyperpigmentation0.83029868
80MP0000566_synostosis0.82222838
81MP0000428_abnormal_craniofacial_morphol0.81986509
82MP0000678_abnormal_parathyroid_gland0.81021030
83MP0008057_abnormal_DNA_replication0.80894438
84MP0003950_abnormal_plasma_membrane0.80335815
85MP0001348_abnormal_lacrimal_gland0.79140641
86MP0005257_abnormal_intraocular_pressure0.78742121
87MP0003633_abnormal_nervous_system0.78691855
88MP0002081_perinatal_lethality0.78564443
89MP0002114_abnormal_axial_skeleton0.78445840
90MP0003890_abnormal_embryonic-extraembry0.78066125
91MP0003631_nervous_system_phenotype0.75962960
92MP0000631_abnormal_neuroendocrine_gland0.75811584
93MP0003935_abnormal_craniofacial_develop0.75745090
94MP0002084_abnormal_developmental_patter0.75682000
95MP0005670_abnormal_white_adipose0.74811504
96MP0003755_abnormal_palate_morphology0.74619477
97MP0000759_abnormal_skeletal_muscle0.73444085
98MP0000579_abnormal_nail_morphology0.72085336
99MP0002697_abnormal_eye_size0.71547132
100MP0000003_abnormal_adipose_tissue0.71321985

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)3.67360005
2Focal motor seizures (HP:0011153)3.39863966
3Epileptic encephalopathy (HP:0200134)2.84488150
4Focal seizures (HP:0007359)2.81761152
5Atonic seizures (HP:0010819)2.73800066
6Febrile seizures (HP:0002373)2.53446608
7Insomnia (HP:0100785)2.43846130
8Cerebral hypomyelination (HP:0006808)2.37371838
9Premature rupture of membranes (HP:0001788)2.35660457
10Abnormality of the phalanges of the hallux (HP:0010057)2.34088739
11Action tremor (HP:0002345)2.23428969
12Transposition of the great arteries (HP:0001669)2.23250305
13Abnormal connection of the cardiac segments (HP:0011545)2.23250305
14Abnormal ventriculo-arterial connection (HP:0011563)2.23250305
15Truncal ataxia (HP:0002078)2.22494572
16Hyperacusis (HP:0010780)2.20541770
17Abnormal number of incisors (HP:0011064)2.14309699
18Supranuclear gaze palsy (HP:0000605)2.10415853
19Protrusio acetabuli (HP:0003179)2.08962077
20Abnormality of the fetal cardiovascular system (HP:0010948)2.06987080
21Abnormal umbilical cord blood vessels (HP:0011403)2.06987080
22Single umbilical artery (HP:0001195)2.06987080
23Ulnar bowing (HP:0003031)2.05302908
24Dysmetric saccades (HP:0000641)2.04707373
25Shallow orbits (HP:0000586)2.01526278
26Poor eye contact (HP:0000817)1.98850125
27Birth length less than 3rd percentile (HP:0003561)1.97654689
28Amblyopia (HP:0000646)1.97517956
29Spinal rigidity (HP:0003306)1.95753416
30Generalized tonic-clonic seizures (HP:0002069)1.95314940
31Septate vagina (HP:0001153)1.88474507
32Spastic gait (HP:0002064)1.87345325
33Epileptiform EEG discharges (HP:0011182)1.87243552
34Obstructive sleep apnea (HP:0002870)1.85312831
35Periauricular skin pits (HP:0100277)1.84852678
36Preauricular pit (HP:0004467)1.84852678
37Dysmetria (HP:0001310)1.84798305
38Annular pancreas (HP:0001734)1.84312428
39Lower limb amyotrophy (HP:0007210)1.81323192
40Broad distal phalanx of finger (HP:0009836)1.81302179
41Turricephaly (HP:0000262)1.80850673
42Depression (HP:0000716)1.80807273
43Increased nuchal translucency (HP:0010880)1.80458234
44Hydroureter (HP:0000072)1.78127857
45Overriding aorta (HP:0002623)1.77837289
46Absence seizures (HP:0002121)1.77014477
47Urinary urgency (HP:0000012)1.75185224
48Abnormality of the umbilical cord (HP:0010881)1.73244464
49Abnormality of the lower motor neuron (HP:0002366)1.72993767
50Renal duplication (HP:0000075)1.72951837
51Abnormality of dentin (HP:0010299)1.72426363
52EEG with generalized epileptiform discharges (HP:0011198)1.71232860
53Bladder diverticulum (HP:0000015)1.63261909
54Mild short stature (HP:0003502)1.62381686
55Abnormality of the astrocytes (HP:0100707)1.62038600
56Astrocytoma (HP:0009592)1.62038600
57Hypsarrhythmia (HP:0002521)1.61796295
58Urethral obstruction (HP:0000796)1.61146322
59Limb dystonia (HP:0002451)1.61079500
60Abnormality of cochlea (HP:0000375)1.60722853
61Hypoventilation (HP:0002791)1.60307314
62Sensory axonal neuropathy (HP:0003390)1.59329627
63Torticollis (HP:0000473)1.57467901
64Impaired smooth pursuit (HP:0007772)1.57134811
65Cerebral inclusion bodies (HP:0100314)1.55427218
66Preaxial foot polydactyly (HP:0001841)1.54478532
67Hypoplasia of the iris (HP:0007676)1.53367897
68Ankle contracture (HP:0006466)1.53059976
69Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.52019415
70Morphological abnormality of the inner ear (HP:0011390)1.51689926
71Dialeptic seizures (HP:0011146)1.51643570
72Bowel diverticulosis (HP:0005222)1.51588463
73Postural instability (HP:0002172)1.50612699
74Abnormality of the 4th metacarpal (HP:0010012)1.50231789
75Genu recurvatum (HP:0002816)1.49784314
76Urinary bladder sphincter dysfunction (HP:0002839)1.49514399
77Abnormality of the distal phalanx of the thumb (HP:0009617)1.48230170
78Duplication of thumb phalanx (HP:0009942)1.47978913
79Premature skin wrinkling (HP:0100678)1.47621442
80Elfin facies (HP:0004428)1.47588004
81Ankle clonus (HP:0011448)1.47533836
82Congenital malformation of the right heart (HP:0011723)1.47509999
83Double outlet right ventricle (HP:0001719)1.47509999
84Skin pits (HP:0100276)1.45704350
85CNS hypomyelination (HP:0003429)1.45580289
86Calcaneovalgus deformity (HP:0001848)1.45235967
87Cutaneous finger syndactyly (HP:0010554)1.45067327
88Renovascular hypertension (HP:0100817)1.44376146
89Bradykinesia (HP:0002067)1.44242604
90Coronal craniosynostosis (HP:0004440)1.44147412
91Megalocornea (HP:0000485)1.43466081
92Flat cornea (HP:0007720)1.42655824
93Ectopic kidney (HP:0000086)1.40636713
94Abnormal social behavior (HP:0012433)1.40238740
95Impaired social interactions (HP:0000735)1.40238740
96High anterior hairline (HP:0009890)1.40129600
97Hammertoe (HP:0001765)1.39669858
98Deformed tarsal bones (HP:0008119)1.39593139
99Resting tremor (HP:0002322)1.39102724
100Pointed chin (HP:0000307)1.38951679

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK3.44132310
2PAK62.91785344
3EPHA42.85851073
4MARK12.82773850
5LATS22.37217414
6NTRK32.34937563
7CDK122.26172758
8MAP3K92.20141249
9PRKD32.13320950
10CAMK1G1.97011621
11ICK1.83343182
12BUB11.77603971
13NTRK11.69905540
14ARAF1.61332438
15BRSK11.58376769
16EEF2K1.58255307
17NTRK21.51771060
18UHMK11.50371327
19DAPK21.49450990
20CASK1.46609398
21PLK21.44855323
22KSR21.44406118
23STK381.40439792
24MINK11.37916866
25CDC71.34439312
26TSSK61.29438435
27SRPK11.24930533
28CCNB11.18372978
29TTK1.15332348
30LATS11.15158203
31WEE11.12576588
32PDGFRA1.10657505
33CAMK1D1.08966435
34RIPK11.08179143
35CAMK11.06652854
36CAMKK11.05965155
37CHEK21.05847585
38CDK151.04822218
39CDK181.01506180
40PHKG21.00543408
41PHKG11.00543408
42CDK11A1.00370931
43PDK20.95931016
44CDK140.92083564
45BRAF0.92074052
46KSR10.90905379
47PRKCG0.88336220
48CAMK40.88061152
49CDK50.87374213
50PBK0.86110298
51WNK10.83909802
52PLK10.81468223
53SIK20.78632706
54TRIM280.78050902
55TRIB30.78006334
56PAK20.77078906
57MAPKAPK50.75929868
58CAMK2B0.75764670
59BRD40.75056358
60AURKA0.74808280
61RAF10.72906398
62MAP3K40.72719936
63PTK20.72097322
64PINK10.71725345
65STK160.69798422
66MAP2K70.69236562
67DAPK10.68982040
68TYRO30.67909210
69CDK80.67575204
70WNK40.67268124
71ERBB40.65647934
72MTOR0.65501586
73PLK30.65431390
74IRAK30.62974171
75NEK10.62588647
76CAMKK20.61470224
77CHEK10.60398263
78CSNK1A1L0.60293813
79MAPK100.59994267
80LIMK10.59517459
81MKNK20.57318596
82CAMK2G0.55850789
83ALK0.55286871
84EPHB20.55231257
85CAMK2A0.55101097
86AKT20.53321288
87CSNK1E0.52665045
88CDK20.51030463
89DDR20.50816325
90CDK10.49917673
91PRPF4B0.49753224
92MAP3K100.49174237
93CSNK1G30.47149333
94ATR0.45632349
95CSNK1G10.45446846
96CDK30.45095862
97MAP2K40.44925317
98CSNK1G20.42782950
99PKN10.41749613
100GRK50.41580638

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.79088617
2Synaptic vesicle cycle_Homo sapiens_hsa047212.60820206
3Vitamin B6 metabolism_Homo sapiens_hsa007502.50517407
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.80605630
5Amphetamine addiction_Homo sapiens_hsa050311.80028260
6GABAergic synapse_Homo sapiens_hsa047271.75676530
7Long-term potentiation_Homo sapiens_hsa047201.70536154
8Morphine addiction_Homo sapiens_hsa050321.69975301
9Circadian entrainment_Homo sapiens_hsa047131.64655588
10Glutamatergic synapse_Homo sapiens_hsa047241.63629705
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.62599187
12Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.59258611
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.55201954
14Cocaine addiction_Homo sapiens_hsa050301.54485154
15Insulin secretion_Homo sapiens_hsa049111.46539651
16Dopaminergic synapse_Homo sapiens_hsa047281.46003567
17DNA replication_Homo sapiens_hsa030301.43611616
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.41704061
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.41338794
20Cell cycle_Homo sapiens_hsa041101.34843948
21Oocyte meiosis_Homo sapiens_hsa041141.33790258
22Glioma_Homo sapiens_hsa052141.23947788
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.23603727
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.23133240
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.19453686
26Hippo signaling pathway_Homo sapiens_hsa043901.18394796
27Gastric acid secretion_Homo sapiens_hsa049711.14752219
28Gap junction_Homo sapiens_hsa045401.12330298
29Cholinergic synapse_Homo sapiens_hsa047251.11872634
30Melanogenesis_Homo sapiens_hsa049161.06530720
31cAMP signaling pathway_Homo sapiens_hsa040240.99486882
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.98967505
33Estrogen signaling pathway_Homo sapiens_hsa049150.97811132
34Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.96767187
35Calcium signaling pathway_Homo sapiens_hsa040200.95240405
36Arginine and proline metabolism_Homo sapiens_hsa003300.94731812
37RNA transport_Homo sapiens_hsa030130.93471316
38Hedgehog signaling pathway_Homo sapiens_hsa043400.92503556
39Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.91871367
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.91152988
41One carbon pool by folate_Homo sapiens_hsa006700.90178590
42Oxytocin signaling pathway_Homo sapiens_hsa049210.88324906
43Mismatch repair_Homo sapiens_hsa034300.88136525
44mRNA surveillance pathway_Homo sapiens_hsa030150.88074525
45Salivary secretion_Homo sapiens_hsa049700.87654837
46cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87649167
47Selenocompound metabolism_Homo sapiens_hsa004500.87013605
48Biosynthesis of amino acids_Homo sapiens_hsa012300.86548806
49Basal cell carcinoma_Homo sapiens_hsa052170.85160276
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.84917513
51Wnt signaling pathway_Homo sapiens_hsa043100.84914274
52Taste transduction_Homo sapiens_hsa047420.84363607
53Sulfur relay system_Homo sapiens_hsa041220.82530858
54Thyroid hormone signaling pathway_Homo sapiens_hsa049190.82071977
55Olfactory transduction_Homo sapiens_hsa047400.80182097
56ErbB signaling pathway_Homo sapiens_hsa040120.79591225
57Circadian rhythm_Homo sapiens_hsa047100.79464515
58Folate biosynthesis_Homo sapiens_hsa007900.78903565
59TGF-beta signaling pathway_Homo sapiens_hsa043500.77805688
60Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76742995
61Arginine biosynthesis_Homo sapiens_hsa002200.76610977
62Axon guidance_Homo sapiens_hsa043600.75409962
63RNA polymerase_Homo sapiens_hsa030200.75026700
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74529022
65Prion diseases_Homo sapiens_hsa050200.73971467
66Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71922976
67Dilated cardiomyopathy_Homo sapiens_hsa054140.70997937
68Long-term depression_Homo sapiens_hsa047300.70278485
69GnRH signaling pathway_Homo sapiens_hsa049120.70173774
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70124465
71Lysine degradation_Homo sapiens_hsa003100.69872850
72Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69048744
73ECM-receptor interaction_Homo sapiens_hsa045120.67956256
74Vibrio cholerae infection_Homo sapiens_hsa051100.66060492
75Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65954729
76Cardiac muscle contraction_Homo sapiens_hsa042600.65394834
77Base excision repair_Homo sapiens_hsa034100.63957037
78Glucagon signaling pathway_Homo sapiens_hsa049220.63617137
79AMPK signaling pathway_Homo sapiens_hsa041520.63423501
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.63275645
81MicroRNAs in cancer_Homo sapiens_hsa052060.62547718
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.61983269
83Thyroid hormone synthesis_Homo sapiens_hsa049180.60417705
84Pyruvate metabolism_Homo sapiens_hsa006200.60416812
85Type II diabetes mellitus_Homo sapiens_hsa049300.59070703
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.58793485
87Spliceosome_Homo sapiens_hsa030400.58758600
88Non-homologous end-joining_Homo sapiens_hsa034500.58691227
89Nucleotide excision repair_Homo sapiens_hsa034200.57805934
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.55752914
91Melanoma_Homo sapiens_hsa052180.53796130
92Alcoholism_Homo sapiens_hsa050340.53774861
93Inositol phosphate metabolism_Homo sapiens_hsa005620.52086633
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49755509
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.49294105
96Fanconi anemia pathway_Homo sapiens_hsa034600.49025035
97Pyrimidine metabolism_Homo sapiens_hsa002400.48774336
98Serotonergic synapse_Homo sapiens_hsa047260.47663384
99Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.47472102
100mTOR signaling pathway_Homo sapiens_hsa041500.46919051

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