C17ORF50

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)8.81554339
2acrosome reaction (GO:0007340)7.70513493
3sperm capacitation (GO:0048240)7.06207369
4axonemal dynein complex assembly (GO:0070286)7.05541295
5spermatid nucleus differentiation (GO:0007289)6.98156132
6microtubule depolymerization (GO:0007019)6.80353786
7fusion of sperm to egg plasma membrane (GO:0007342)6.47212783
8epithelial cilium movement (GO:0003351)6.37328167
9spermatid development (GO:0007286)6.21596644
10motile cilium assembly (GO:0044458)6.12354450
11response to pheromone (GO:0019236)5.94942418
12cilium movement (GO:0003341)5.71147384
13rRNA methylation (GO:0031167)5.55172726
14single strand break repair (GO:0000012)5.50689671
15chromosome condensation (GO:0030261)5.36392784
16cilium or flagellum-dependent cell motility (GO:0001539)5.29572604
17regulation of cilium movement (GO:0003352)5.27259721
18DNA packaging (GO:0006323)5.23321027
19microtubule polymerization or depolymerization (GO:0031109)5.18555262
20protein polyglutamylation (GO:0018095)5.18380241
21negative regulation of inclusion body assembly (GO:0090084)5.12066915
22rRNA modification (GO:0000154)5.01680292
23plasma membrane fusion (GO:0045026)4.82398773
24centriole replication (GO:0007099)4.67917451
25multicellular organism reproduction (GO:0032504)4.66683272
26sperm-egg recognition (GO:0035036)4.63579679
27sequestering of actin monomers (GO:0042989)4.59249576
28sexual reproduction (GO:0019953)4.57993763
29seminiferous tubule development (GO:0072520)4.51065046
30microtubule severing (GO:0051013)4.49798594
31reproduction (GO:0000003)4.48681606
32phosphatidylethanolamine biosynthetic process (GO:0006646)4.47384996
33RNA destabilization (GO:0050779)4.44211267
34calcium ion-dependent exocytosis (GO:0017156)4.40404721
35phosphatidylethanolamine metabolic process (GO:0046337)4.30293995
36epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.29985215
37spermatogenesis (GO:0007283)4.29446104
38male gamete generation (GO:0048232)4.27387913
39mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.11115753
40centriole assembly (GO:0098534)4.10683796
41binding of sperm to zona pellucida (GO:0007339)3.98059648
42gamete generation (GO:0007276)3.90014707
43protein targeting to Golgi (GO:0000042)3.89839157
44protein complex biogenesis (GO:0070271)3.88865800
45mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.86701245
46mitochondrial respiratory chain complex I assembly (GO:0032981)3.86701245
47NADH dehydrogenase complex assembly (GO:0010257)3.86701245
48cell-cell recognition (GO:0009988)3.75018461
49regulation of inclusion body assembly (GO:0090083)3.72476279
50retrograde transport, vesicle recycling within Golgi (GO:0000301)3.69361766
51establishment of protein localization to Golgi (GO:0072600)3.68506645
52single fertilization (GO:0007338)3.67175384
53ATP synthesis coupled proton transport (GO:0015986)3.55019155
54energy coupled proton transport, down electrochemical gradient (GO:0015985)3.55019155
55dopaminergic neuron differentiation (GO:0071542)3.53042530
56cellular ketone body metabolic process (GO:0046950)3.47261445
57C4-dicarboxylate transport (GO:0015740)3.45749806
58G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.44418927
59mitochondrial respiratory chain complex assembly (GO:0033108)3.43924216
60protein localization to cilium (GO:0061512)3.40304439
61regulation of microtubule-based movement (GO:0060632)3.40116392
62pyrimidine nucleotide catabolic process (GO:0006244)3.38836093
63intraciliary transport (GO:0042073)3.36249084
64short-term memory (GO:0007614)3.33835125
65axoneme assembly (GO:0035082)3.24580441
66germ cell development (GO:0007281)3.20737455
67ventricular system development (GO:0021591)3.19106701
68protein localization to Golgi apparatus (GO:0034067)3.18527342
69estrogen biosynthetic process (GO:0006703)3.17984065
70protein neddylation (GO:0045116)3.11444830
71regulation of transcription involved in cell fate commitment (GO:0060850)3.10441741
72GTP biosynthetic process (GO:0006183)3.08325252
73multicellular organismal reproductive process (GO:0048609)3.06965757
74ketone body metabolic process (GO:1902224)3.06260550
75cellular process involved in reproduction in multicellular organism (GO:0022412)3.05378360
76organic cation transport (GO:0015695)2.98141166
77mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.97366475
78ribosomal small subunit assembly (GO:0000028)2.96999402
79cilium assembly (GO:0042384)2.95994173
80cilium organization (GO:0044782)2.95568134
81polyamine biosynthetic process (GO:0006596)2.94527026
82pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.93664204
83spinal cord motor neuron differentiation (GO:0021522)2.91345311
84fertilization (GO:0009566)2.90236011
85establishment of protein localization to mitochondrial membrane (GO:0090151)2.89285357
86multicellular organismal movement (GO:0050879)2.87654571
87musculoskeletal movement (GO:0050881)2.87654571
88positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.81148841
89nucleoside diphosphate phosphorylation (GO:0006165)2.77951301
90viral transcription (GO:0019083)2.77516594
91negative regulation of appetite (GO:0032099)2.75944851
92negative regulation of response to food (GO:0032096)2.75944851
93translational termination (GO:0006415)2.69653664
94respiratory electron transport chain (GO:0022904)2.69253754
95sleep (GO:0030431)2.68228920
96electron transport chain (GO:0022900)2.67702824
97transmission of nerve impulse (GO:0019226)2.62869128
98tooth mineralization (GO:0034505)2.62776824
99regulation of collateral sprouting (GO:0048670)2.62761021
100spliceosomal complex assembly (GO:0000245)2.60342343

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.31158891
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.04706059
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.91401831
4MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.59624077
5CTBP1_25329375_ChIP-Seq_LNCAP_Human2.49472879
6VDR_22108803_ChIP-Seq_LS180_Human2.45677357
7POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.43139826
8TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.43139826
9FUS_26573619_Chip-Seq_HEK293_Human2.42486777
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.41893151
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.17864985
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.93841774
13ER_23166858_ChIP-Seq_MCF-7_Human1.87183137
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.86048033
15IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.83943799
16CBP_20019798_ChIP-Seq_JUKART_Human1.83943799
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.82815528
18BMI1_23680149_ChIP-Seq_NPCS_Mouse1.81554119
19* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.81462425
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.80441261
21TP63_19390658_ChIP-ChIP_HaCaT_Human1.75494045
22DROSHA_22980978_ChIP-Seq_HELA_Human1.72959724
23ZNF274_21170338_ChIP-Seq_K562_Hela1.67946468
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.67852718
25TAF2_19829295_ChIP-Seq_ESCs_Human1.63435975
26ERA_21632823_ChIP-Seq_H3396_Human1.62216240
27NANOG_20526341_ChIP-Seq_ESCs_Human1.60380230
28YY1_22570637_ChIP-Seq_MALME-3M_Human1.58740682
29TAF15_26573619_Chip-Seq_HEK293_Human1.56123624
30SUZ12_27294783_Chip-Seq_ESCs_Mouse1.55060265
31REST_21632747_ChIP-Seq_MESCs_Mouse1.54526913
32CBX2_27304074_Chip-Seq_ESCs_Mouse1.51690180
33* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.51368249
34* RAC3_21632823_ChIP-Seq_H3396_Human1.49633189
35ERG_20517297_ChIP-Seq_VCAP_Human1.49395101
36* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.47740490
37VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.45023572
38UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44580582
39EZH2_27294783_Chip-Seq_ESCs_Mouse1.44257950
40CTCF_27219007_Chip-Seq_Bcells_Human1.41481093
41AR_25329375_ChIP-Seq_VCAP_Human1.40736286
42TDRD3_21172665_ChIP-Seq_MCF-7_Human1.39421470
43P300_19829295_ChIP-Seq_ESCs_Human1.39254406
44EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.38166269
45* ETV2_25802403_ChIP-Seq_MESCs_Mouse1.37633504
46SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.37187407
47PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.34377383
48EZH2_27304074_Chip-Seq_ESCs_Mouse1.32103594
49E2F1_20622854_ChIP-Seq_HELA_Human1.31813135
50WDR5_24793694_ChIP-Seq_LNCAP_Human1.31812998
51* BCL6_27268052_Chip-Seq_Bcells_Human1.30411007
52ELF1_20517297_ChIP-Seq_JURKAT_Human1.29557623
53AUTS2_25519132_ChIP-Seq_293T-REX_Human1.29148443
54EED_16625203_ChIP-ChIP_MESCs_Mouse1.28360176
55JARID2_20064375_ChIP-Seq_MESCs_Mouse1.27591493
56MYC_19829295_ChIP-Seq_ESCs_Human1.25130828
57OCT4_20526341_ChIP-Seq_ESCs_Human1.24996789
58PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23812615
59GBX2_23144817_ChIP-Seq_PC3_Human1.22323920
60SOX2_22085726_ChIP-Seq_NPCs_Mouse1.21378732
61SMAD4_21799915_ChIP-Seq_A2780_Human1.20535950
62HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.18888757
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17131357
64P300_27268052_Chip-Seq_Bcells_Human1.16951709
65RUNX1_26923725_Chip-Seq_HPCs_Mouse1.16031342
66NANOG_19829295_ChIP-Seq_ESCs_Human1.15804962
67SOX2_19829295_ChIP-Seq_ESCs_Human1.15804962
68GATA3_21878914_ChIP-Seq_MCF-7_Human1.15487823
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15011573
70CTCF_20526341_ChIP-Seq_ESCs_Human1.14483158
71JARID2_20075857_ChIP-Seq_MESCs_Mouse1.11110208
72PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10979191
73CEBPB_22108803_ChIP-Seq_LS180_Human1.10028708
74* PHF8_20622854_ChIP-Seq_HELA_Human1.09742131
75BCOR_27268052_Chip-Seq_Bcells_Human1.07830777
76SMAD3_21741376_ChIP-Seq_EPCs_Human1.07384701
77PHF8_20622853_ChIP-Seq_HELA_Human1.06740998
78NFYB_21822215_ChIP-Seq_K562_Human1.06534881
79SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.06181097
80RNF2_27304074_Chip-Seq_NSC_Mouse1.04931238
81P53_21459846_ChIP-Seq_SAOS-2_Human1.04395982
82SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.03118213
83ETV1_20927104_ChIP-Seq_GIST48_Human1.02961209
84REST_18959480_ChIP-ChIP_MESCs_Mouse1.02402467
85SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01931811
86RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01847543
87TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00157616
88P68_20966046_ChIP-Seq_HELA_Human0.98013651
89SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.97927972
90CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.95909652
91SMAD4_21741376_ChIP-Seq_EPCs_Human0.95895179
92KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.95543276
93RBPJ_21746931_ChIP-Seq_IB4_Human0.95162328
94SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.94834135
95HNFA_21074721_ChIP-Seq_CACO-2_Human0.94819634
96NFYA_21822215_ChIP-Seq_K562_Human0.94067982
97TP53_22573176_ChIP-Seq_HFKS_Human0.93141115
98TBL1_22424771_ChIP-Seq_293T_Human0.93098585
99TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92513262
100P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.92153707

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization8.13338130
2MP0003136_yellow_coat_color3.22798395
3MP0003698_abnormal_male_reproductive3.20362885
4MP0005423_abnormal_somatic_nervous2.87740969
5MP0005670_abnormal_white_adipose2.82772258
6MP0002822_catalepsy2.69852122
7MP0002735_abnormal_chemical_nociception2.67379927
8MP0001929_abnormal_gametogenesis2.66999422
9MP0003878_abnormal_ear_physiology2.62604202
10MP0005377_hearing/vestibular/ear_phenot2.62604202
11MP0000566_synostosis2.56136733
12MP0003880_abnormal_central_pattern2.46408631
13MP0001968_abnormal_touch/_nociception2.30693399
14MP0002234_abnormal_pharynx_morphology2.30678891
15MP0002736_abnormal_nociception_after2.25101972
16MP0003011_delayed_dark_adaptation1.86868486
17MP0003718_maternal_effect1.79910279
18MP0009745_abnormal_behavioral_response1.76316115
19MP0009379_abnormal_foot_pigmentation1.71845587
20MP0002161_abnormal_fertility/fecundity1.71509425
21MP0002132_abnormal_respiratory_system1.68142964
22MP0005551_abnormal_eye_electrophysiolog1.66995994
23MP0001529_abnormal_vocalization1.66600403
24MP0001905_abnormal_dopamine_level1.65335166
25MP0006276_abnormal_autonomic_nervous1.57759684
26MP0002733_abnormal_thermal_nociception1.55436337
27MP0002938_white_spotting1.54277060
28MP0002064_seizures1.52416285
29MP0001970_abnormal_pain_threshold1.49947689
30MP0001984_abnormal_olfaction1.49838842
31MP0005171_absent_coat_pigmentation1.47449134
32MP0002572_abnormal_emotion/affect_behav1.40670884
33MP0001486_abnormal_startle_reflex1.39132629
34MP0002210_abnormal_sex_determination1.38451961
35MP0002653_abnormal_ependyma_morphology1.36325243
36MP0002272_abnormal_nervous_system1.35219220
37MP0002734_abnormal_mechanical_nocicepti1.30982135
38MP0004145_abnormal_muscle_electrophysio1.30500372
39MP0002067_abnormal_sensory_capabilities1.30393946
40MP0005253_abnormal_eye_physiology1.30244584
41MP0003646_muscle_fatigue1.25907398
42MP0009278_abnormal_bone_marrow1.25572648
43MP0004859_abnormal_synaptic_plasticity1.24726884
44MP0009046_muscle_twitch1.23988050
45MP0005379_endocrine/exocrine_gland_phen1.22930520
46MP0008569_lethality_at_weaning1.20433121
47MP0003635_abnormal_synaptic_transmissio1.19308276
48MP0008995_early_reproductive_senescence1.11956978
49MP0005310_abnormal_salivary_gland1.11261175
50MP0001440_abnormal_grooming_behavior1.10894591
51MP0002557_abnormal_social/conspecific_i1.07320031
52MP0000653_abnormal_sex_gland1.05549369
53MP0001145_abnormal_male_reproductive1.04418610
54MP0000026_abnormal_inner_ear1.03939530
55MP0006072_abnormal_retinal_apoptosis1.03088887
56MP0002282_abnormal_trachea_morphology0.99573516
57MP0004142_abnormal_muscle_tone0.98587190
58MP0000372_irregular_coat_pigmentation0.98340251
59MP0008961_abnormal_basal_metabolism0.97847005
60MP0004085_abnormal_heartbeat0.95345635
61MP0005535_abnormal_body_temperature0.93562814
62MP0003137_abnormal_impulse_conducting0.92332012
63MP0005084_abnormal_gallbladder_morpholo0.90870743
64MP0003868_abnormal_feces_composition0.90373254
65MP0001666_abnormal_nutrient_absorption0.87082739
66MP0008789_abnormal_olfactory_epithelium0.86874564
67MP0006292_abnormal_olfactory_placode0.85584872
68MP0002184_abnormal_innervation0.85379111
69MP0003950_abnormal_plasma_membrane0.85101118
70MP0008872_abnormal_physiological_respon0.85027449
71MP0002063_abnormal_learning/memory/cond0.84458244
72MP0001963_abnormal_hearing_physiology0.84337219
73MP0003283_abnormal_digestive_organ0.83546858
74MP0010329_abnormal_lipoprotein_level0.83003269
75MP0003879_abnormal_hair_cell0.80735090
76MP0000230_abnormal_systemic_arterial0.80726344
77MP0005075_abnormal_melanosome_morpholog0.79561890
78MP0002160_abnormal_reproductive_system0.78142452
79MP0005448_abnormal_energy_balance0.77312708
80MP0001346_abnormal_lacrimal_gland0.75932732
81MP0001348_abnormal_lacrimal_gland0.75843633
82MP0003119_abnormal_digestive_system0.73473547
83MP0005397_hematopoietic_system_phenotyp0.73382518
84MP0001545_abnormal_hematopoietic_system0.73382518
85MP0000678_abnormal_parathyroid_gland0.70962387
86MP0001986_abnormal_taste_sensitivity0.70391585
87MP0009765_abnormal_xenobiotic_induced0.70353737
88MP0001485_abnormal_pinna_reflex0.68627478
89MP0000955_abnormal_spinal_cord0.67166637
90MP0001765_abnormal_ion_homeostasis0.66633632
91MP0004742_abnormal_vestibular_system0.64789967
92MP0001919_abnormal_reproductive_system0.64499078
93MP0004510_myositis0.64302854
94MP0001501_abnormal_sleep_pattern0.63156269
95MP0003638_abnormal_response/metabolism_0.62699047
96MP0003567_abnormal_fetal_cardiomyocyte0.62034076
97MP0002876_abnormal_thyroid_physiology0.61646936
98MP0005645_abnormal_hypothalamus_physiol0.60592519
99MP0005365_abnormal_bile_salt0.59861754
100MP0000049_abnormal_middle_ear0.59683849

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)6.76193454
2Absent/shortened dynein arms (HP:0200106)6.76193454
3Abnormal ciliary motility (HP:0012262)6.20402699
4Abnormal respiratory epithelium morphology (HP:0012253)5.95995081
5Abnormal respiratory motile cilium morphology (HP:0005938)5.95995081
6Abnormal respiratory motile cilium physiology (HP:0012261)5.85457432
7Renal Fanconi syndrome (HP:0001994)4.76686769
8Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.76526674
9Rhinitis (HP:0012384)4.06670423
10Severe visual impairment (HP:0001141)3.78820106
11Bony spicule pigmentary retinopathy (HP:0007737)3.74107811
12Hepatocellular necrosis (HP:0001404)3.53539003
13Tubulointerstitial nephritis (HP:0001970)3.47904530
14Increased hepatocellular lipid droplets (HP:0006565)3.47886856
15Mitochondrial inheritance (HP:0001427)3.47148486
16Chronic hepatic failure (HP:0100626)3.40560029
17Myokymia (HP:0002411)3.38270003
18Abnormal rod and cone electroretinograms (HP:0008323)3.17439433
19Nasal polyposis (HP:0100582)3.17115256
20Decreased central vision (HP:0007663)3.14999074
21Lipid accumulation in hepatocytes (HP:0006561)3.14838969
22Acute necrotizing encephalopathy (HP:0006965)3.13659960
23Attenuation of retinal blood vessels (HP:0007843)3.03522215
24Abnormality of renal resorption (HP:0011038)3.02627055
25Hepatic necrosis (HP:0002605)2.97564986
26Impulsivity (HP:0100710)2.97419626
27Decreased activity of mitochondrial respiratory chain (HP:0008972)2.92276525
28Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.92276525
29Infertility (HP:0000789)2.91412807
30Increased intramyocellular lipid droplets (HP:0012240)2.85482870
31Exertional dyspnea (HP:0002875)2.83932297
32Progressive cerebellar ataxia (HP:0002073)2.82421997
33Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.80419733
34Abnormal mitochondria in muscle tissue (HP:0008316)2.79968583
35Generalized aminoaciduria (HP:0002909)2.77889940
36Nephronophthisis (HP:0000090)2.77340788
37Chronic otitis media (HP:0000389)2.74145063
38Hypoplasia of the thymus (HP:0000778)2.71272287
39Chronic sinusitis (HP:0011109)2.64797776
40Focal motor seizures (HP:0011153)2.51514505
41Increased CSF lactate (HP:0002490)2.47303795
42Male infertility (HP:0003251)2.46763404
43Progressive macrocephaly (HP:0004481)2.44215383
44Acute encephalopathy (HP:0006846)2.43235307
45Abnormality of the nasal mucosa (HP:0000433)2.37578703
46Increased muscle lipid content (HP:0009058)2.37053414
47Bronchiectasis (HP:0002110)2.36678809
48Chronic bronchitis (HP:0004469)2.36543282
493-Methylglutaconic aciduria (HP:0003535)2.35568213
50Glycosuria (HP:0003076)2.32140729
51Abnormality of urine glucose concentration (HP:0011016)2.32140729
52Medial flaring of the eyebrow (HP:0010747)2.26662249
53Spastic paraparesis (HP:0002313)2.23844352
54Congenital stationary night blindness (HP:0007642)2.22789215
55Abnormality of the renal medulla (HP:0100957)2.16956327
56Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.15327946
57Abnormal drinking behavior (HP:0030082)2.14153536
58Polydipsia (HP:0001959)2.14153536
59Optic disc pallor (HP:0000543)2.10948162
60Hyperphosphaturia (HP:0003109)2.02356657
61Hyperkalemia (HP:0002153)2.01237171
62Abnormal number of erythroid precursors (HP:0012131)2.00690093
63Sensory axonal neuropathy (HP:0003390)1.99627745
64Molar tooth sign on MRI (HP:0002419)1.98148721
65Abnormality of midbrain morphology (HP:0002418)1.98148721
66Hypoalbuminemia (HP:0003073)1.95916705
67Abnormal albumin level (HP:0012116)1.95916705
68Abnormality of macular pigmentation (HP:0008002)1.92232982
69Pancreatic cysts (HP:0001737)1.91041805
70Potter facies (HP:0002009)1.90327760
71Facial shape deformation (HP:0011334)1.90327760
72Cerebral edema (HP:0002181)1.88594045
73Abnormal urine output (HP:0012590)1.88540848
74Tubulointerstitial abnormality (HP:0001969)1.84912957
75Renal dysplasia (HP:0000110)1.84106141
76Resting tremor (HP:0002322)1.83371065
77Pancreatic fibrosis (HP:0100732)1.83218029
78Absent rod-and cone-mediated responses on ERG (HP:0007688)1.83119272
79Cone-rod dystrophy (HP:0000548)1.83067209
80Atonic seizures (HP:0010819)1.81472277
81Panhypogammaglobulinemia (HP:0003139)1.79608561
82Polyuria (HP:0000103)1.79436035
83Emotional lability (HP:0000712)1.78176774
84Aplasia/Hypoplasia of the earlobes (HP:0009906)1.76863004
85Dyschromatopsia (HP:0007641)1.74219167
86Congenital, generalized hypertrichosis (HP:0004540)1.73395613
87Sclerocornea (HP:0000647)1.72604948
88Tetany (HP:0001281)1.70266978
89Increased corneal curvature (HP:0100692)1.69386012
90Keratoconus (HP:0000563)1.69386012
91Gait imbalance (HP:0002141)1.67659306
92Portal hypertension (HP:0001409)1.67297238
93Amelogenesis imperfecta (HP:0000705)1.66090775
94Exercise intolerance (HP:0003546)1.65303553
95Muscle fiber atrophy (HP:0100295)1.64890969
96Abnormality of the hepatic vasculature (HP:0006707)1.62967738
97Abnormality of cells of the erythroid lineage (HP:0012130)1.62293412
98Abnormality of the aortic arch (HP:0012303)1.61577784
99True hermaphroditism (HP:0010459)1.61293149
100Genital tract atresia (HP:0001827)1.60988687

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMKK24.83006436
2PNCK4.78543340
3PLK44.62680117
4MAPK153.29566023
5TESK13.17313155
6TLK12.86901897
7TAF12.21442287
8INSRR2.18413615
9VRK22.17396870
10MAPK131.95664487
11PLK21.94569228
12STK381.93756463
13DYRK21.92779185
14CAMKK11.87171610
15TNIK1.81877541
16TAOK31.78414426
17CCNB11.76533701
18SIK21.71908887
19DYRK31.60371396
20KDR1.56323059
21WNK31.52292281
22VRK11.51960973
23BMPR1B1.45510963
24MAP4K21.44923989
25STK38L1.38307280
26PRKD31.37682554
27PTK2B1.32906753
28DDR21.27141807
29CAMK1G1.11473973
30MAP3K41.11187652
31GRK11.10586380
32STK161.10029294
33WNK41.07109522
34CAMK11.04916894
35TEC1.01704586
36ADRBK21.01378637
37MARK11.01056554
38TYRO30.98697284
39ZAK0.98551302
40DYRK1B0.97040316
41PINK10.87540133
42STK390.87501923
43BCKDK0.81535043
44GRK50.81300086
45EPHA30.79816074
46NME10.77949128
47MAPKAPK50.77529760
48TESK20.76974813
49OXSR10.76390255
50CAMK40.76209906
51MUSK0.74569551
52RPS6KA50.73431856
53CAMK2A0.70096307
54GRK70.68045768
55ACVR1B0.67763766
56GRK60.64920637
57MAP2K70.64781537
58NEK60.64131541
59MINK10.63730884
60SYK0.63404683
61NLK0.62428798
62KIT0.60200896
63CDC70.58400870
64PRKCG0.57608965
65TXK0.57243543
66PRKACA0.57119686
67BRSK20.53271130
68CDK70.50647448
69CSF1R0.47057504
70RIPK40.46913324
71ITK0.46418781
72BRD40.43223228
73CDK140.42435156
74TGFBR10.41044270
75NUAK10.40774918
76BTK0.40561529
77PASK0.40143102
78PRKG10.39306014
79MAP3K110.39133676
80FGFR20.35246809
81PRKCB0.35194759
82CHEK20.35052053
83ADRBK10.34660336
84CAMK2B0.34492081
85MAPKAPK30.33104144
86IKBKB0.33035298
87SGK2230.30843245
88SGK4940.30843245
89UHMK10.30083387
90CDK80.29033714
91ABL20.28442513
92AURKA0.27763462
93RPS6KA10.26770496
94MAP4K10.26638178
95PRKCA0.26529516
96TNK20.25739326
97CDK11A0.25522062
98CLK10.24552271
99PRKCE0.23679137
100RPS6KA60.22992054

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000613.72422137
2Oxidative phosphorylation_Homo sapiens_hsa001903.64662713
3Ribosome_Homo sapiens_hsa030103.33887079
4Parkinsons disease_Homo sapiens_hsa050123.16635477
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.95921121
6Huntingtons disease_Homo sapiens_hsa050162.83232848
7Olfactory transduction_Homo sapiens_hsa047402.67164615
8Protein export_Homo sapiens_hsa030602.62987069
9Cardiac muscle contraction_Homo sapiens_hsa042602.42204680
10Phototransduction_Homo sapiens_hsa047442.17617270
11Alzheimers disease_Homo sapiens_hsa050102.15367546
12Nicotine addiction_Homo sapiens_hsa050331.84455169
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.80483065
14Nitrogen metabolism_Homo sapiens_hsa009101.79881517
15Taste transduction_Homo sapiens_hsa047421.79647698
16Linoleic acid metabolism_Homo sapiens_hsa005911.69788486
17Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.63525015
18RNA polymerase_Homo sapiens_hsa030201.58813369
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.58589151
20Proteasome_Homo sapiens_hsa030501.54086844
21Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.53208056
22Glutamatergic synapse_Homo sapiens_hsa047241.42328422
23Circadian entrainment_Homo sapiens_hsa047131.42187302
24Purine metabolism_Homo sapiens_hsa002301.34953539
25Butanoate metabolism_Homo sapiens_hsa006501.32442143
26Type I diabetes mellitus_Homo sapiens_hsa049401.31585860
27Morphine addiction_Homo sapiens_hsa050321.26704015
28Fanconi anemia pathway_Homo sapiens_hsa034601.24012072
29Glycerophospholipid metabolism_Homo sapiens_hsa005641.23367602
30Asthma_Homo sapiens_hsa053101.21493339
31GABAergic synapse_Homo sapiens_hsa047271.20783887
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.20483074
33Autoimmune thyroid disease_Homo sapiens_hsa053201.18539214
34Antigen processing and presentation_Homo sapiens_hsa046121.18002513
35Allograft rejection_Homo sapiens_hsa053301.16028566
36Calcium signaling pathway_Homo sapiens_hsa040201.14766841
37Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.11780347
38Fatty acid degradation_Homo sapiens_hsa000711.11442992
39Serotonergic synapse_Homo sapiens_hsa047261.11267805
40Salivary secretion_Homo sapiens_hsa049701.10358615
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.10165286
42Graft-versus-host disease_Homo sapiens_hsa053321.08068273
43Primary immunodeficiency_Homo sapiens_hsa053401.07665508
44Pyrimidine metabolism_Homo sapiens_hsa002401.07394184
45Homologous recombination_Homo sapiens_hsa034401.01137780
46Arachidonic acid metabolism_Homo sapiens_hsa005900.94785751
47Fat digestion and absorption_Homo sapiens_hsa049750.88900080
48Systemic lupus erythematosus_Homo sapiens_hsa053220.88402574
49Cocaine addiction_Homo sapiens_hsa050300.87953774
50Fatty acid metabolism_Homo sapiens_hsa012120.85604817
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84387425
52Intestinal immune network for IgA production_Homo sapiens_hsa046720.84320306
53Phenylalanine metabolism_Homo sapiens_hsa003600.83348263
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82585488
55Chemical carcinogenesis_Homo sapiens_hsa052040.82528487
56Ether lipid metabolism_Homo sapiens_hsa005650.79088158
57Regulation of autophagy_Homo sapiens_hsa041400.77775780
58Steroid hormone biosynthesis_Homo sapiens_hsa001400.72409602
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69227011
60RNA transport_Homo sapiens_hsa030130.67284280
61Tyrosine metabolism_Homo sapiens_hsa003500.66645835
62Amphetamine addiction_Homo sapiens_hsa050310.66536205
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.65972345
64Metabolic pathways_Homo sapiens_hsa011000.65028435
65Collecting duct acid secretion_Homo sapiens_hsa049660.64563343
66Peroxisome_Homo sapiens_hsa041460.62477780
67Basal transcription factors_Homo sapiens_hsa030220.61425122
68PPAR signaling pathway_Homo sapiens_hsa033200.59930351
69Alcoholism_Homo sapiens_hsa050340.59590776
70Base excision repair_Homo sapiens_hsa034100.59498632
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58314132
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.58127671
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57098848
74Hematopoietic cell lineage_Homo sapiens_hsa046400.56335204
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55983753
76Pancreatic secretion_Homo sapiens_hsa049720.53905170
77Gastric acid secretion_Homo sapiens_hsa049710.53869613
78Synaptic vesicle cycle_Homo sapiens_hsa047210.53337560
79Renin secretion_Homo sapiens_hsa049240.53156854
80Glutathione metabolism_Homo sapiens_hsa004800.52391582
81Type II diabetes mellitus_Homo sapiens_hsa049300.51353833
82Spliceosome_Homo sapiens_hsa030400.48015243
83Dorso-ventral axis formation_Homo sapiens_hsa043200.47639109
84Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46315843
85Glycerolipid metabolism_Homo sapiens_hsa005610.45623286
86Oxytocin signaling pathway_Homo sapiens_hsa049210.45383005
87cAMP signaling pathway_Homo sapiens_hsa040240.45182163
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39424277
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39343218
90Hedgehog signaling pathway_Homo sapiens_hsa043400.37973601
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.37555331
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36132434
93Oocyte meiosis_Homo sapiens_hsa041140.35015389
94Platelet activation_Homo sapiens_hsa046110.34589144
95Ovarian steroidogenesis_Homo sapiens_hsa049130.34134139
96Viral myocarditis_Homo sapiens_hsa054160.32229228
97Arginine and proline metabolism_Homo sapiens_hsa003300.31006580
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30910025
99Cholinergic synapse_Homo sapiens_hsa047250.30666934
100ABC transporters_Homo sapiens_hsa020100.30343885

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