C16ORF92

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.03491878
2neurofilament cytoskeleton organization (GO:0060052)5.79682588
3pyrimidine nucleobase catabolic process (GO:0006208)5.58408657
4substrate-independent telencephalic tangential interneuron migration (GO:0021843)5.47483473
5substrate-independent telencephalic tangential migration (GO:0021826)5.47483473
6locomotory exploration behavior (GO:0035641)5.17981756
7neuronal ion channel clustering (GO:0045161)4.90782859
8establishment of mitochondrion localization (GO:0051654)4.87174140
9mitochondrion transport along microtubule (GO:0047497)4.82627388
10establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.82627388
11parturition (GO:0007567)4.71885019
12neuron recognition (GO:0008038)4.43483192
13protein neddylation (GO:0045116)4.39006062
14nucleobase catabolic process (GO:0046113)4.36792790
15positive regulation of gastrulation (GO:2000543)4.31997628
16forebrain neuron differentiation (GO:0021879)4.31707474
17regulation of cilium movement (GO:0003352)4.29520750
18axonal fasciculation (GO:0007413)4.19085345
19cerebellar Purkinje cell differentiation (GO:0021702)4.15706133
20spinal cord association neuron differentiation (GO:0021527)4.12863398
21protein polyglutamylation (GO:0018095)4.09602975
22tachykinin receptor signaling pathway (GO:0007217)4.07146780
23regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.97583020
24regulation of microtubule-based movement (GO:0060632)3.96236913
25body morphogenesis (GO:0010171)3.94481015
26positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.93190033
27presynaptic membrane organization (GO:0097090)3.89093646
28exploration behavior (GO:0035640)3.88080210
29cell proliferation in forebrain (GO:0021846)3.85450892
30cell migration in hindbrain (GO:0021535)3.74339799
31axon extension (GO:0048675)3.63626506
32synaptic transmission, dopaminergic (GO:0001963)3.62529608
33glucocorticoid biosynthetic process (GO:0006704)3.58353733
34adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.57117795
35transmission of nerve impulse (GO:0019226)3.52308581
36positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.49051025
37adult walking behavior (GO:0007628)3.45893094
38regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.42769767
39cell-cell junction maintenance (GO:0045217)3.39727560
40negative regulation of neurotransmitter secretion (GO:0046929)3.38145179
41negative regulation of catecholamine secretion (GO:0033604)3.37837110
42axon ensheathment in central nervous system (GO:0032291)3.35695737
43central nervous system myelination (GO:0022010)3.35695737
44embryonic body morphogenesis (GO:0010172)3.32090047
45protein localization to synapse (GO:0035418)3.29740262
46positive regulation of growth hormone secretion (GO:0060124)3.29531489
47hypothalamus development (GO:0021854)3.22954910
48microtubule bundle formation (GO:0001578)3.22584731
49membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.21677438
50head development (GO:0060322)3.20204345
51postsynaptic membrane organization (GO:0001941)3.15838923
52retinal ganglion cell axon guidance (GO:0031290)3.14973869
53ganglion development (GO:0061548)3.09287922
54auditory behavior (GO:0031223)3.07695833
55synaptic transmission, cholinergic (GO:0007271)3.03290551
56regulation of glutamate receptor signaling pathway (GO:1900449)2.99712497
57neuron projection extension (GO:1990138)2.98471856
58cell differentiation in hindbrain (GO:0021533)2.97842408
59ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.97225651
60genetic imprinting (GO:0071514)2.94558713
61phenylpropanoid metabolic process (GO:0009698)2.90847566
62cell junction maintenance (GO:0034331)2.89094582
63ATP synthesis coupled proton transport (GO:0015986)2.88925248
64energy coupled proton transport, down electrochemical gradient (GO:0015985)2.88925248
65synaptic vesicle maturation (GO:0016188)2.88892990
66establishment or maintenance of monopolar cell polarity (GO:0061339)2.88713413
67establishment of monopolar cell polarity (GO:0061162)2.88713413
68camera-type eye morphogenesis (GO:0048593)2.87154231
69dendritic spine morphogenesis (GO:0060997)2.87062105
70calcium ion-dependent exocytosis (GO:0017156)2.85983229
71synapse assembly (GO:0007416)2.84409118
72neuron projection extension involved in neuron projection guidance (GO:1902284)2.84211529
73axon extension involved in axon guidance (GO:0048846)2.84211529
74short-term memory (GO:0007614)2.81931340
75viral transcription (GO:0019083)2.81835861
76negative regulation of transcription regulatory region DNA binding (GO:2000678)2.81526812
77microtubule severing (GO:0051013)2.81451654
78epithelial cilium movement (GO:0003351)2.81287475
79urogenital system development (GO:0001655)2.80176740
80dopamine receptor signaling pathway (GO:0007212)2.79286771
81ovulation cycle (GO:0042698)2.78941416
82mechanosensory behavior (GO:0007638)2.78093396
83neuron migration (GO:0001764)2.76118338
84spinal cord development (GO:0021510)2.76024420
85uterus development (GO:0060065)2.75194472
86regulation of gonadotropin secretion (GO:0032276)2.75000647
87regulation of synapse structural plasticity (GO:0051823)2.74927725
88epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.73010837
89cell differentiation in spinal cord (GO:0021515)2.69335420
90translational termination (GO:0006415)2.69262079
91striatum development (GO:0021756)2.69253205
92negative regulation of norepinephrine secretion (GO:0010700)2.66230668
93membrane repolarization during action potential (GO:0086011)2.66029393
94behavioral response to ethanol (GO:0048149)2.64443699
95regulation of neuron migration (GO:2001222)2.64359860
96dendrite development (GO:0016358)2.64339510
97membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.62342085
98phosphorelay signal transduction system (GO:0000160)2.61539366
99neuronal action potential propagation (GO:0019227)2.61536359
100olfactory bulb development (GO:0021772)2.61376126

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.69657134
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.04494880
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse4.14059816
4REST_21632747_ChIP-Seq_MESCs_Mouse2.98181856
5EZH2_27304074_Chip-Seq_ESCs_Mouse2.92683366
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.73194704
7SUZ12_27294783_Chip-Seq_ESCs_Mouse2.57546756
8EZH2_27294783_Chip-Seq_ESCs_Mouse2.53413750
9CBX2_27304074_Chip-Seq_ESCs_Mouse2.53243117
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.43271675
11BMI1_23680149_ChIP-Seq_NPCS_Mouse2.41459213
12REST_18959480_ChIP-ChIP_MESCs_Mouse2.36755512
13CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.27521749
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.23533132
15RNF2_27304074_Chip-Seq_ESCs_Mouse2.21505815
16IKZF1_21737484_ChIP-ChIP_HCT116_Human2.20121490
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.18881339
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.18881339
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.09540906
20SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.08927419
21RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.06038797
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.96727404
23ERG_21242973_ChIP-ChIP_JURKAT_Human1.85190994
24PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.82065027
25RNF2_27304074_Chip-Seq_NSC_Mouse1.80604501
26SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.79186627
27RING1B_27294783_Chip-Seq_ESCs_Mouse1.78065280
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.73828863
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72394362
30GATA1_26923725_Chip-Seq_HPCs_Mouse1.67914934
31SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.62765666
32RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.59841658
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56887687
34TP53_20018659_ChIP-ChIP_R1E_Mouse1.55773637
35SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.55521988
36OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.55077152
37MTF2_20144788_ChIP-Seq_MESCs_Mouse1.53879738
38* CTCF_27219007_Chip-Seq_Bcells_Human1.53356975
39RBPJ_22232070_ChIP-Seq_NCS_Mouse1.49453485
40BP1_19119308_ChIP-ChIP_Hs578T_Human1.46795557
41ZNF274_21170338_ChIP-Seq_K562_Hela1.45758106
42DROSHA_22980978_ChIP-Seq_HELA_Human1.41267034
43RARB_27405468_Chip-Seq_BRAIN_Mouse1.38425275
44RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34481435
45VDR_22108803_ChIP-Seq_LS180_Human1.31804001
46SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.30381291
47MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.27745846
48TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25451527
49POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25451527
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22797245
51CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.22238210
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20102062
53ETV2_25802403_ChIP-Seq_MESCs_Mouse1.19914264
54GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.19744930
55IRF1_19129219_ChIP-ChIP_H3396_Human1.15508894
56KDM2B_26808549_Chip-Seq_K562_Human1.09554851
57RING1B_27294783_Chip-Seq_NPCs_Mouse1.05553234
58CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.04959013
59ZFP281_18757296_ChIP-ChIP_E14_Mouse1.03824360
60P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02651379
61ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02366811
62SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.01869817
63SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01370501
64CTBP2_25329375_ChIP-Seq_LNCAP_Human0.98605124
65NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.94509611
66SMAD3_21741376_ChIP-Seq_ESCs_Human0.94218196
67MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92584480
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.92542388
69KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.92358179
70GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92011134
71SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.87762944
72FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.86327676
73TOP2B_26459242_ChIP-Seq_MCF-7_Human0.84907440
74MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.84804081
75GBX2_23144817_ChIP-Seq_PC3_Human0.84109100
76TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82424440
77EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.81617217
78P300_19829295_ChIP-Seq_ESCs_Human0.81377140
79STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.81072762
80CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80428082
81* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.79641092
82TAF2_19829295_ChIP-Seq_ESCs_Human0.79541604
83EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.79327150
84SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.78661709
85ZFP281_27345836_Chip-Seq_ESCs_Mouse0.77743718
86ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.77199241
87NCOR_22424771_ChIP-Seq_293T_Human0.76435259
88* OCT4_19829295_ChIP-Seq_ESCs_Human0.76110809
89DNAJC2_21179169_ChIP-ChIP_NT2_Human0.75937361
90SMAD4_21799915_ChIP-Seq_A2780_Human0.75587569
91AR_25329375_ChIP-Seq_VCAP_Human0.75239539
92AR_19668381_ChIP-Seq_PC3_Human0.75007201
93ERA_21632823_ChIP-Seq_H3396_Human0.74557021
94RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.74543390
95POU5F1_16153702_ChIP-ChIP_HESCs_Human0.74335618
96EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.72703488
97KLF5_20875108_ChIP-Seq_MESCs_Mouse0.72300988
98TAL1_26923725_Chip-Seq_HPCs_Mouse0.72223481
99EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.71999909
100TP53_22573176_ChIP-Seq_HFKS_Human0.71818841

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting4.70637841
2MP0003123_paternal_imprinting3.92980578
3MP0005423_abnormal_somatic_nervous3.43221666
4MP0006276_abnormal_autonomic_nervous3.17198408
5MP0003880_abnormal_central_pattern3.12035814
6MP0006292_abnormal_olfactory_placode2.95224543
7MP0000778_abnormal_nervous_system2.69280087
8MP0003121_genomic_imprinting2.56498423
9MP0004859_abnormal_synaptic_plasticity2.54627253
10MP0003122_maternal_imprinting2.50218950
11MP0002653_abnormal_ependyma_morphology2.48700320
12MP0001188_hyperpigmentation2.39930821
13MP0002822_catalepsy2.21918924
14MP0000955_abnormal_spinal_cord2.18672153
15MP0002163_abnormal_gland_morphology2.16949877
16MP0009379_abnormal_foot_pigmentation2.11966645
17MP0002272_abnormal_nervous_system2.08383847
18MP0008789_abnormal_olfactory_epithelium2.04145511
19MP0005394_taste/olfaction_phenotype2.03017734
20MP0005499_abnormal_olfactory_system2.03017734
21MP0002184_abnormal_innervation1.98922133
22MP0003890_abnormal_embryonic-extraembry1.91045002
23MP0003635_abnormal_synaptic_transmissio1.87042378
24MP0001348_abnormal_lacrimal_gland1.80216353
25MP0001529_abnormal_vocalization1.76663191
26MP0008877_abnormal_DNA_methylation1.74489986
27MP0001485_abnormal_pinna_reflex1.74453504
28MP0004142_abnormal_muscle_tone1.73748430
29MP0004145_abnormal_muscle_electrophysio1.65191394
30MP0004742_abnormal_vestibular_system1.61190170
31MP0005551_abnormal_eye_electrophysiolog1.58389266
32MP0002557_abnormal_social/conspecific_i1.56727226
33MP0002882_abnormal_neuron_morphology1.56318471
34MP0002063_abnormal_learning/memory/cond1.55604020
35MP0009046_muscle_twitch1.55465534
36MP0001970_abnormal_pain_threshold1.54076696
37MP0002752_abnormal_somatic_nervous1.53994453
38MP0009745_abnormal_behavioral_response1.53024181
39MP0002734_abnormal_mechanical_nocicepti1.52930647
40MP0001440_abnormal_grooming_behavior1.51919659
41MP0002572_abnormal_emotion/affect_behav1.48687469
42MP0003879_abnormal_hair_cell1.47608509
43MP0002733_abnormal_thermal_nociception1.45955767
44MP0002909_abnormal_adrenal_gland1.44742109
45MP0003646_muscle_fatigue1.42370081
46MP0004133_heterotaxia1.41075658
47MP0001986_abnormal_taste_sensitivity1.40352890
48MP0004811_abnormal_neuron_physiology1.39700804
49MP0003011_delayed_dark_adaptation1.35923841
50MP0004270_analgesia1.34963233
51MP0002160_abnormal_reproductive_system1.34757860
52MP0005646_abnormal_pituitary_gland1.34252724
53MP0002067_abnormal_sensory_capabilities1.30600211
54MP0003942_abnormal_urinary_system1.27466289
55MP0002064_seizures1.26892324
56MP0004885_abnormal_endolymph1.24601001
57MP0001968_abnormal_touch/_nociception1.24183173
58MP0001486_abnormal_startle_reflex1.22140096
59MP0005379_endocrine/exocrine_gland_phen1.21130804
60MP0002638_abnormal_pupillary_reflex1.17224882
61MP0002876_abnormal_thyroid_physiology1.16988277
62MP0000631_abnormal_neuroendocrine_gland1.16153236
63MP0004130_abnormal_muscle_cell1.14773923
64MP0001984_abnormal_olfaction1.11868711
65MP0005645_abnormal_hypothalamus_physiol1.11850533
66MP0002152_abnormal_brain_morphology1.11358962
67MP0002735_abnormal_chemical_nociception1.09427362
68MP0001905_abnormal_dopamine_level1.08337650
69MP0005195_abnormal_posterior_eye1.06331641
70MP0003315_abnormal_perineum_morphology1.06055289
71MP0003861_abnormal_nervous_system1.02390492
72MP0002229_neurodegeneration1.00532542
73MP0000026_abnormal_inner_ear0.99484116
74MP0000534_abnormal_ureter_morphology0.96572595
75MP0002837_dystrophic_cardiac_calcinosis0.95354084
76MP0004134_abnormal_chest_morphology0.95127665
77MP0000049_abnormal_middle_ear0.93902222
78MP0004924_abnormal_behavior0.89382196
79MP0005386_behavior/neurological_phenoty0.89382196
80MP0005389_reproductive_system_phenotype0.88156654
81MP0003938_abnormal_ear_development0.86531230
82MP0000569_abnormal_digit_pigmentation0.85706471
83MP0002928_abnormal_bile_duct0.85701836
84MP0002066_abnormal_motor_capabilities/c0.79939648
85MP0006072_abnormal_retinal_apoptosis0.78853040
86MP0001963_abnormal_hearing_physiology0.77687152
87MP0009053_abnormal_anal_canal0.77369897
88MP0003878_abnormal_ear_physiology0.76947749
89MP0005377_hearing/vestibular/ear_phenot0.76947749
90MP0003119_abnormal_digestive_system0.73952128
91MP0002736_abnormal_nociception_after0.73240946
92MP0002102_abnormal_ear_morphology0.72234707
93MP0001286_abnormal_eye_development0.71050957
94MP0002751_abnormal_autonomic_nervous0.70399346
95MP0001293_anophthalmia0.70085031
96MP0005410_abnormal_fertilization0.69986022
97MP0001919_abnormal_reproductive_system0.69803932
98MP0008775_abnormal_heart_ventricle0.69156763
99MP0003385_abnormal_body_wall0.65223982
100MP0005084_abnormal_gallbladder_morpholo0.64644269

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.00942086
2Abnormal pancreas size (HP:0012094)4.62884615
3Rib fusion (HP:0000902)3.79589258
4Hepatoblastoma (HP:0002884)3.62919857
5Diastasis recti (HP:0001540)3.61726052
6Polyphagia (HP:0002591)3.50310551
7Agitation (HP:0000713)3.42009416
8Anomalous pulmonary venous return (HP:0010772)3.32310470
9Molar tooth sign on MRI (HP:0002419)3.14157696
10Abnormality of midbrain morphology (HP:0002418)3.14157696
11Adrenal hypoplasia (HP:0000835)3.13989438
12Progressive cerebellar ataxia (HP:0002073)3.00730550
13Limb dystonia (HP:0002451)2.94310886
14Neoplasm of the adrenal cortex (HP:0100641)2.93916597
15Growth hormone deficiency (HP:0000824)2.91892840
16Anosmia (HP:0000458)2.90766134
17Nephronophthisis (HP:0000090)2.89282448
18Neonatal hypoglycemia (HP:0001998)2.89112617
19Medial flaring of the eyebrow (HP:0010747)2.85752605
20Abnormality of the pulmonary veins (HP:0011718)2.84931722
21Gait imbalance (HP:0002141)2.79051590
22Fetal akinesia sequence (HP:0001989)2.77519676
23Hypogonadotrophic hypogonadism (HP:0000044)2.77497375
24Pancreatic fibrosis (HP:0100732)2.71540928
25Chronic hepatic failure (HP:0100626)2.58226184
26Abnormality of cells of the erythroid lineage (HP:0012130)2.57312648
27Impaired vibration sensation in the lower limbs (HP:0002166)2.56698161
28Abnormality of the labia minora (HP:0012880)2.52229690
29Abnormal hair whorl (HP:0010721)2.51509813
30Broad-based gait (HP:0002136)2.50941188
31Abnormality of the corticospinal tract (HP:0002492)2.49368699
32Vaginal atresia (HP:0000148)2.48046814
33Hyperthyroidism (HP:0000836)2.46224406
34Myotonia (HP:0002486)2.44504977
35Reticulocytopenia (HP:0001896)2.42991247
36Metaphyseal dysplasia (HP:0100255)2.40279977
37Failure to thrive in infancy (HP:0001531)2.40156983
38Pachygyria (HP:0001302)2.40036174
39Genital tract atresia (HP:0001827)2.39022926
40Aplasia/Hypoplasia of the brainstem (HP:0007362)2.38083631
41Hypoplasia of the brainstem (HP:0002365)2.38083631
42Abnormality of the renal medulla (HP:0100957)2.35610719
43Epileptic encephalopathy (HP:0200134)2.35188168
44Nephrogenic diabetes insipidus (HP:0009806)2.34848697
45Congenital primary aphakia (HP:0007707)2.34839659
46Bony spicule pigmentary retinopathy (HP:0007737)2.34755981
47Congenital stationary night blindness (HP:0007642)2.33118406
48Supranuclear gaze palsy (HP:0000605)2.29455665
49True hermaphroditism (HP:0010459)2.27585301
50Tubular atrophy (HP:0000092)2.25843412
51Pancreatic cysts (HP:0001737)2.20476279
52Absent rod-and cone-mediated responses on ERG (HP:0007688)2.18298590
53Lissencephaly (HP:0001339)2.18122023
54Labial hypoplasia (HP:0000066)2.15525341
55Drooling (HP:0002307)2.13971229
56Optic nerve coloboma (HP:0000588)2.11897182
57Renal Fanconi syndrome (HP:0001994)2.11292612
58Urinary bladder sphincter dysfunction (HP:0002839)2.07082144
59Osteomalacia (HP:0002749)2.04576732
60Sclerocornea (HP:0000647)2.02889165
61Amblyopia (HP:0000646)2.01763021
62Type II lissencephaly (HP:0007260)2.01213886
63Acute necrotizing encephalopathy (HP:0006965)2.00417555
64Chorioretinal atrophy (HP:0000533)1.99128132
65Abnormal respiratory epithelium morphology (HP:0012253)1.98577374
66Abnormal respiratory motile cilium morphology (HP:0005938)1.98577374
67Poor suck (HP:0002033)1.94905881
68Abnormality of renal resorption (HP:0011038)1.94556298
69Bifid tongue (HP:0010297)1.93675165
70Excessive salivation (HP:0003781)1.93329586
71Thoracolumbar scoliosis (HP:0002944)1.92124854
72Spastic tetraplegia (HP:0002510)1.91680903
73Abnormal number of erythroid precursors (HP:0012131)1.90752988
74Poor coordination (HP:0002370)1.90645393
75Hypoplastic female external genitalia (HP:0012815)1.90597371
76Abnormality of the right ventricle (HP:0001707)1.90490626
77Polydipsia (HP:0001959)1.89160551
78Abnormal drinking behavior (HP:0030082)1.89160551
79Hyperphosphatemia (HP:0002905)1.86770850
80Focal seizures (HP:0007359)1.86389077
81Anencephaly (HP:0002323)1.84836597
82Abnormal mitochondria in muscle tissue (HP:0008316)1.82285404
83Stenosis of the external auditory canal (HP:0000402)1.80785027
84Decreased circulating renin level (HP:0003351)1.80391881
85Pendular nystagmus (HP:0012043)1.79957836
86Specific learning disability (HP:0001328)1.79479346
87Mitochondrial inheritance (HP:0001427)1.79478426
88Anophthalmia (HP:0000528)1.77155890
89Narrow forehead (HP:0000341)1.76619345
90Abnormal rod and cone electroretinograms (HP:0008323)1.76421465
91Abnormal eating behavior (HP:0100738)1.74685587
92Double outlet right ventricle (HP:0001719)1.73520166
93Congenital malformation of the right heart (HP:0011723)1.73520166
94Restlessness (HP:0000711)1.71513281
95Left ventricular hypertrophy (HP:0001712)1.70680607
96Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.70678216
97Macrocytic anemia (HP:0001972)1.69777985
98Hip dysplasia (HP:0001385)1.69230575
99Oligodactyly (hands) (HP:0001180)1.68908582
100Shawl scrotum (HP:0000049)1.67998688

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.01273885
2SIK24.05968887
3MAP3K93.65729050
4MARK13.54366778
5MINK13.43634499
6NTRK33.12354832
7DYRK22.76095832
8NTRK22.40085274
9WNK32.39417714
10WNK42.33689507
11MAP2K72.23717807
12STK162.07376712
13DYRK31.97454780
14MAP3K41.70734913
15ICK1.60450482
16TYRO31.59458332
17SGK4941.53298517
18SGK2231.53298517
19PRKCG1.52630873
20CAMK1D1.42306768
21TNIK1.41017760
22PINK11.37522344
23MAP3K111.37406322
24CAMK1G1.36830961
25ADRBK21.35884846
26STK111.33229254
27BMPR1B1.30126604
28PAK31.28800733
29MAPK131.27419983
30RPS6KA21.20884190
31DYRK1B1.20741073
32MARK21.20159603
33PNCK1.18056039
34EPHB21.14801518
35CAMKK11.13814624
36MAP2K41.13148853
37NEK21.11327729
38SGK21.10739669
39PRKCH1.08395386
40FRK1.06586522
41CDK51.06187375
42DAPK21.01757427
43CSNK1G21.01272901
44BRAF1.00789775
45GRK10.93881753
46DYRK1A0.87483182
47EPHA40.83724954
48LIMK10.83652886
49SGK30.80016455
50ARAF0.79463971
51CDK190.78889877
52DMPK0.76549239
53CSNK1E0.73675850
54PHKG10.72233686
55PHKG20.72233686
56PRKCZ0.68497238
57PRKACA0.64459055
58CAMK10.64243967
59STK390.61611530
60INSRR0.61548503
61MAPK150.61271393
62SGK10.61121453
63MARK30.57159397
64WNK10.56175771
65CSNK1A10.55399740
66ZAK0.55067121
67CAMKK20.54668910
68TLK10.54506718
69STK380.54250161
70BCR0.54197414
71CDK140.54019880
72PRKCI0.51569722
73AKT30.48866151
74RPS6KA60.47395298
75OXSR10.46528298
76MAPK80.46174970
77PRKG10.46012743
78CSNK1G30.45016042
79ERBB20.44745336
80AKT10.42904213
81KSR10.41394508
82PRKCQ0.40762157
83PRKCD0.39933419
84CDK150.39706563
85PRKD30.39133405
86PRKAA10.38984386
87UHMK10.38532306
88RPS6KA30.38124548
89TIE10.37876370
90ALK0.37497585
91CDK11A0.36962056
92PIK3CA0.36304553
93CAMK2A0.36290140
94MAP3K60.36275279
95PTK60.35812164
96MUSK0.35763213
97RPS6KC10.34940621
98RPS6KL10.34940621
99PKN10.34775301
100CSNK1A1L0.33944037

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.74426939
2Cardiac muscle contraction_Homo sapiens_hsa042603.35145149
3Parkinsons disease_Homo sapiens_hsa050123.33857699
4Nicotine addiction_Homo sapiens_hsa050333.19031799
5Phototransduction_Homo sapiens_hsa047442.73484003
6Ribosome_Homo sapiens_hsa030102.71756164
7Morphine addiction_Homo sapiens_hsa050322.39007082
8Alzheimers disease_Homo sapiens_hsa050102.36081277
9Huntingtons disease_Homo sapiens_hsa050162.32012951
10Synaptic vesicle cycle_Homo sapiens_hsa047212.30532828
11GABAergic synapse_Homo sapiens_hsa047272.16776626
12Insulin secretion_Homo sapiens_hsa049112.15106960
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.13794704
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.08374238
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.02166977
16Axon guidance_Homo sapiens_hsa043602.02166093
17Glutamatergic synapse_Homo sapiens_hsa047242.01453567
18Dopaminergic synapse_Homo sapiens_hsa047281.92435543
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.90832078
20Long-term depression_Homo sapiens_hsa047301.76587044
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.75946519
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.74351689
23Circadian entrainment_Homo sapiens_hsa047131.72294445
24Cholinergic synapse_Homo sapiens_hsa047251.62310654
25Serotonergic synapse_Homo sapiens_hsa047261.55601534
26Cocaine addiction_Homo sapiens_hsa050301.44417766
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.36818924
28Collecting duct acid secretion_Homo sapiens_hsa049661.31678595
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.27345001
30Olfactory transduction_Homo sapiens_hsa047401.23891161
31Linoleic acid metabolism_Homo sapiens_hsa005911.21536199
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.21302828
33Steroid biosynthesis_Homo sapiens_hsa001001.12042985
34Oxytocin signaling pathway_Homo sapiens_hsa049211.05832936
35Amphetamine addiction_Homo sapiens_hsa050311.01097334
36Taste transduction_Homo sapiens_hsa047420.98963567
37Gap junction_Homo sapiens_hsa045400.98763765
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.98570490
39Notch signaling pathway_Homo sapiens_hsa043300.97225871
40Hedgehog signaling pathway_Homo sapiens_hsa043400.97126349
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.95373718
42Basal cell carcinoma_Homo sapiens_hsa052170.94688365
43Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.94346275
44Aldosterone synthesis and secretion_Homo sapiens_hsa049250.90106627
45Dilated cardiomyopathy_Homo sapiens_hsa054140.85665496
46Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.84083171
47MAPK signaling pathway_Homo sapiens_hsa040100.81136278
48Ether lipid metabolism_Homo sapiens_hsa005650.80142913
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.79940179
50Ovarian steroidogenesis_Homo sapiens_hsa049130.79127557
51Gastric acid secretion_Homo sapiens_hsa049710.78296681
52Alcoholism_Homo sapiens_hsa050340.78235099
53Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77322005
54cAMP signaling pathway_Homo sapiens_hsa040240.75006930
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67919431
56Butanoate metabolism_Homo sapiens_hsa006500.67882165
57Ras signaling pathway_Homo sapiens_hsa040140.63042677
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.62219724
59Melanogenesis_Homo sapiens_hsa049160.61949505
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61095606
61Sulfur relay system_Homo sapiens_hsa041220.60875856
62Fat digestion and absorption_Homo sapiens_hsa049750.60575177
63Calcium signaling pathway_Homo sapiens_hsa040200.60269768
64Regulation of autophagy_Homo sapiens_hsa041400.60015135
65Salivary secretion_Homo sapiens_hsa049700.59091690
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58672988
67Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56873560
68Long-term potentiation_Homo sapiens_hsa047200.54174268
69Renin secretion_Homo sapiens_hsa049240.53566434
70Peroxisome_Homo sapiens_hsa041460.53368638
71Wnt signaling pathway_Homo sapiens_hsa043100.52508006
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.50391128
73Type II diabetes mellitus_Homo sapiens_hsa049300.49890158
74Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49749611
75Protein export_Homo sapiens_hsa030600.48944213
76GnRH signaling pathway_Homo sapiens_hsa049120.47985981
77Retinol metabolism_Homo sapiens_hsa008300.47308592
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46932880
79Hippo signaling pathway_Homo sapiens_hsa043900.46569779
80Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.46062765
81Thyroid hormone synthesis_Homo sapiens_hsa049180.45164039
82Tryptophan metabolism_Homo sapiens_hsa003800.45033324
83Glycerolipid metabolism_Homo sapiens_hsa005610.44722136
84Rap1 signaling pathway_Homo sapiens_hsa040150.44458573
85Basal transcription factors_Homo sapiens_hsa030220.43744363
86Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43629676
87Caffeine metabolism_Homo sapiens_hsa002320.38838675
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.37207451
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36867647
90Bile secretion_Homo sapiens_hsa049760.36845998
91Pancreatic secretion_Homo sapiens_hsa049720.36805456
92Dorso-ventral axis formation_Homo sapiens_hsa043200.36729332
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36405702
94ErbB signaling pathway_Homo sapiens_hsa040120.35141670
95VEGF signaling pathway_Homo sapiens_hsa043700.34279121
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.33123117
97Metabolic pathways_Homo sapiens_hsa011000.31561605
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.30201707
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.30061944
100RNA polymerase_Homo sapiens_hsa030200.26567853

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