C16ORF82

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)8.69891130
2multicellular organism reproduction (GO:0032504)8.66118835
3regulation of phosphoprotein phosphatase activity (GO:0043666)8.60616630
4binding of sperm to zona pellucida (GO:0007339)8.51760793
5sperm-egg recognition (GO:0035036)7.93571534
6axonemal dynein complex assembly (GO:0070286)7.55952618
7male meiosis (GO:0007140)7.49081658
8motile cilium assembly (GO:0044458)7.17538710
9reproduction (GO:0000003)7.07121625
10positive regulation of synaptic transmission, dopaminergic (GO:0032226)7.04607831
11cell-cell recognition (GO:0009988)6.77708518
12plasma membrane fusion (GO:0045026)6.69232920
13sperm capacitation (GO:0048240)6.60842682
14nucleosome disassembly (GO:0006337)6.50814150
15protein-DNA complex disassembly (GO:0032986)6.50814150
16cilium or flagellum-dependent cell motility (GO:0001539)6.46496150
17positive regulation of catecholamine secretion (GO:0033605)6.44328946
18phosphatidylethanolamine biosynthetic process (GO:0006646)6.34240792
19negative regulation of inclusion body assembly (GO:0090084)6.27498670
20calcium ion-dependent exocytosis (GO:0017156)6.21546683
21organic cation transport (GO:0015695)5.99649066
22polyamine biosynthetic process (GO:0006596)5.97656890
23microtubule depolymerization (GO:0007019)5.92896636
24single fertilization (GO:0007338)5.92589413
25phosphatidylethanolamine metabolic process (GO:0046337)5.83569446
26germ cell development (GO:0007281)5.81791991
27epithelial cilium movement (GO:0003351)5.81644577
28chromosome condensation (GO:0030261)5.73603748
29spermatid nucleus differentiation (GO:0007289)5.70259668
30DNA packaging (GO:0006323)5.54349959
31protein polyglutamylation (GO:0018095)5.27743557
32spermatogenesis (GO:0007283)5.26646655
33male gamete generation (GO:0048232)5.24597516
34cellular process involved in reproduction in multicellular organism (GO:0022412)5.01254850
35protein targeting to Golgi (GO:0000042)4.89790909
36cilium movement (GO:0003341)4.85244958
37response to acidic pH (GO:0010447)4.84886846
38gamete generation (GO:0007276)4.84663365
39rRNA methylation (GO:0031167)4.82249674
40single strand break repair (GO:0000012)4.81976684
41establishment of protein localization to Golgi (GO:0072600)4.67350144
42microtubule polymerization or depolymerization (GO:0031109)4.55109587
43coenzyme catabolic process (GO:0009109)4.54813903
44regulation of oxidative stress-induced neuron death (GO:1903203)4.54161278
45retrograde transport, vesicle recycling within Golgi (GO:0000301)4.50248777
46fertilization (GO:0009566)4.50152922
47microtubule severing (GO:0051013)4.47290188
48male sex determination (GO:0030238)4.41397501
49potassium ion export (GO:0071435)4.30668094
50ventricular system development (GO:0021591)4.29868902
51relaxation of smooth muscle (GO:0044557)4.28608067
52regulation of inclusion body assembly (GO:0090083)4.27825834
53centriole assembly (GO:0098534)4.25475192
54synapsis (GO:0007129)4.20846241
55histone exchange (GO:0043486)4.11066005
56regulation of oxidative phosphorylation (GO:0002082)4.07714793
57response to pheromone (GO:0019236)4.05908591
58regulation of cilium movement (GO:0003352)4.03986130
59Leydig cell differentiation (GO:0033327)4.01190373
60cellular biogenic amine biosynthetic process (GO:0042401)3.97210829
61rRNA modification (GO:0000154)3.94342895
62multicellular organismal reproductive process (GO:0048609)3.93513862
63positive regulation of glycolytic process (GO:0045821)3.90959856
64amine biosynthetic process (GO:0009309)3.85986664
65mitochondrion degradation (GO:0000422)3.84077564
66activation of protein kinase B activity (GO:0032148)3.83017715
67sexual reproduction (GO:0019953)3.81846297
68cellular response to pH (GO:0071467)3.79150319
69histone H3-K9 demethylation (GO:0033169)3.74821092
70cGMP-mediated signaling (GO:0019934)3.74264977
71cellular ketone body metabolic process (GO:0046950)3.72927805
72acrosome assembly (GO:0001675)3.52264014
73centriole replication (GO:0007099)3.51113824
74positive regulation of Rab GTPase activity (GO:0032851)3.48694946
75regulation of Rab GTPase activity (GO:0032313)3.48694946
76protein localization to Golgi apparatus (GO:0034067)3.43144953
77protein polymerization (GO:0051258)3.40720308
78regulation of transcription involved in cell fate commitment (GO:0060850)3.39107148
79regulation of dopamine secretion (GO:0014059)3.36010927
80negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.34450457
81oogenesis (GO:0048477)3.34272008
82polyamine metabolic process (GO:0006595)3.31936389
83cell recognition (GO:0008037)3.31849751
84regulation of phosphatase activity (GO:0010921)3.31481963
85ketone body metabolic process (GO:1902224)3.27637507
86epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.27484810
87meiotic nuclear division (GO:0007126)3.26014128
88glutamine family amino acid catabolic process (GO:0009065)3.24417971
89chromosome organization involved in meiosis (GO:0070192)3.19740479
90regulation of ARF GTPase activity (GO:0032312)3.19725620
91detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.13714509
92piRNA metabolic process (GO:0034587)3.11234047
93cranial nerve morphogenesis (GO:0021602)3.07381804
94negative regulation of response to reactive oxygen species (GO:1901032)3.03151661
95regulation of hydrogen peroxide-induced cell death (GO:1903205)3.01921905
96regulation of autophagic vacuole assembly (GO:2000785)2.96768010
97TOR signaling (GO:0031929)2.93317548
98acrosome reaction (GO:0007340)12.4217779
99sperm motility (GO:0030317)12.0921532
100spermatid development (GO:0007286)10.2142215

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse8.02936447
2BP1_19119308_ChIP-ChIP_Hs578T_Human7.03814775
3VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human3.16137220
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.05869863
5MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.99730199
6IGF1R_20145208_ChIP-Seq_DFB_Human2.89338051
7EZH2_22144423_ChIP-Seq_EOC_Human2.71085666
8TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.52119985
9POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.52119985
10FUS_26573619_Chip-Seq_HEK293_Human2.41856506
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.33249221
12ESR1_20079471_ChIP-ChIP_T-47D_Human2.25168296
13* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.21311806
14CTBP1_25329375_ChIP-Seq_LNCAP_Human2.18257107
15IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.09049521
16CBP_20019798_ChIP-Seq_JUKART_Human2.09049521
17NANOG_20526341_ChIP-Seq_ESCs_Human2.01902437
18RAC3_21632823_ChIP-Seq_H3396_Human1.90456532
19CTCF_27219007_Chip-Seq_Bcells_Human1.84608668
20* ARNT_22903824_ChIP-Seq_MCF-7_Human1.80004091
21ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.78557808
22ER_23166858_ChIP-Seq_MCF-7_Human1.77709765
23WDR5_24793694_ChIP-Seq_LNCAP_Human1.72879430
24UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.65694867
25* ERA_21632823_ChIP-Seq_H3396_Human1.65348837
26AR_21572438_ChIP-Seq_LNCaP_Human1.64622444
27SMC4_20622854_ChIP-Seq_HELA_Human1.63883075
28AHR_22903824_ChIP-Seq_MCF-7_Human1.63469729
29OCT4_20526341_ChIP-Seq_ESCs_Human1.60898456
30MYC_19829295_ChIP-Seq_ESCs_Human1.57373585
31SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.56546378
32* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.54787171
33EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.52231424
34ERG_20517297_ChIP-Seq_VCAP_Human1.51211359
35RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.50066653
36TP53_18474530_ChIP-ChIP_U2OS_Human1.49782911
37OCT1_27270436_Chip-Seq_PROSTATE_Human1.46450146
38TBL1_22424771_ChIP-Seq_293T_Human1.43052525
39GBX2_23144817_ChIP-Seq_PC3_Human1.42591300
40EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.41425362
41SMAD4_21741376_ChIP-Seq_EPCs_Human1.39242111
42KLF5_20875108_ChIP-Seq_MESCs_Mouse1.36611880
43P300_19829295_ChIP-Seq_ESCs_Human1.35875274
44CTCF_20526341_ChIP-Seq_ESCs_Human1.34220023
45AR_25329375_ChIP-Seq_VCAP_Human1.32996021
46PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.28051303
47RUNX2_22187159_ChIP-Seq_PCA_Human1.26121252
48* SMAD3_21741376_ChIP-Seq_EPCs_Human1.25230198
49AUTS2_25519132_ChIP-Seq_293T-REX_Human1.25217005
50PHF8_20622854_ChIP-Seq_HELA_Human1.20712590
51ELF1_20517297_ChIP-Seq_JURKAT_Human1.18920679
52CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.18748199
53P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.18728805
54P68_20966046_ChIP-Seq_HELA_Human1.16915923
55LXR_22292898_ChIP-Seq_THP-1_Human1.14896776
56SOX2_19829295_ChIP-Seq_ESCs_Human1.14284590
57NANOG_19829295_ChIP-Seq_ESCs_Human1.14284590
58HNFA_21074721_ChIP-Seq_CACO-2_Human1.13047338
59BCL6_27268052_Chip-Seq_Bcells_Human1.12725986
60VDR_22108803_ChIP-Seq_LS180_Human1.12127058
61TP63_22573176_ChIP-Seq_HFKS_Human1.11520181
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11189899
63TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.10984762
64* SMAD4_21799915_ChIP-Seq_A2780_Human1.10789786
65CBX2_22325352_ChIP-Seq_293T-Rex_Human1.10464708
66PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09466458
67NFYB_21822215_ChIP-Seq_K562_Human1.09191541
68RBPJ_21746931_ChIP-Seq_IB4_Human1.08351778
69EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07796666
70E2F1_20622854_ChIP-Seq_HELA_Human1.07732088
71SPI1_20517297_ChIP-Seq_HL60_Human1.07640995
72YY1_22570637_ChIP-Seq_MALME-3M_Human1.06284380
73CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04802866
74SMAD3_21741376_ChIP-Seq_ESCs_Human1.04724964
75P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03760135
76* P300_27268052_Chip-Seq_Bcells_Human1.03649260
77PHF8_20622853_ChIP-Seq_HELA_Human1.03444675
78MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.01492973
79SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.01267444
80GATA3_21878914_ChIP-Seq_MCF-7_Human1.00295627
81TDRD3_21172665_ChIP-Seq_MCF-7_Human1.00106436
82ETV1_20927104_ChIP-Seq_GIST48_Human0.99608194
83HOXB7_26014856_ChIP-Seq_BT474_Human0.99069668
84BCOR_27268052_Chip-Seq_Bcells_Human0.98999667
85DROSHA_22980978_ChIP-Seq_HELA_Human0.96496892
86GF1_26923725_Chip-Seq_HPCs_Mouse0.96410661
87* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94619143
88E2F1_17053090_ChIP-ChIP_MCF-7_Human0.94449353
89FOXH1_21741376_ChIP-Seq_ESCs_Human0.93779500
90RAD21_21589869_ChIP-Seq_MESCs_Mouse0.93090080
91EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91284395
92GATA6_21074721_ChIP-Seq_CACO-2_Human0.91175490
93* STAT3_23295773_ChIP-Seq_U87_Human0.90953520
94NFYA_21822215_ChIP-Seq_K562_Human0.90397528
95EZH2_27294783_Chip-Seq_ESCs_Mouse0.89901481
96BCAT_22108803_ChIP-Seq_LS180_Human0.88580771
97* PRDM14_20953172_ChIP-Seq_ESCs_Human0.88152540
98RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.87967587
99TAF2_19829295_ChIP-Seq_ESCs_Human0.86740721
100RXR_22108803_ChIP-Seq_LS180_Human0.85050859

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003315_abnormal_perineum_morphology4.64112865
2MP0003698_abnormal_male_reproductive4.48393399
3MP0008004_abnormal_stomach_pH4.30747781
4MP0001929_abnormal_gametogenesis3.96400276
5MP0005377_hearing/vestibular/ear_phenot3.12255049
6MP0003878_abnormal_ear_physiology3.12255049
7MP0005360_urolithiasis2.51149881
8MP0002132_abnormal_respiratory_system2.50990267
9MP0005670_abnormal_white_adipose2.50404958
10MP0002161_abnormal_fertility/fecundity2.42533424
11MP0002160_abnormal_reproductive_system2.42247856
12MP0005410_abnormal_fertilization12.7383733
13MP0002210_abnormal_sex_determination1.99796896
14MP0003045_fibrosis1.92041755
15MP0003718_maternal_effect1.86647125
16MP0001984_abnormal_olfaction1.86105173
17MP0001145_abnormal_male_reproductive1.75217098
18MP0005647_abnormal_sex_gland1.74775410
19MP0000653_abnormal_sex_gland1.60471048
20MP0010386_abnormal_urinary_bladder1.57737371
21MP0000678_abnormal_parathyroid_gland1.56231601
22MP0003136_yellow_coat_color1.44797160
23MP0001905_abnormal_dopamine_level1.43523863
24MP0005499_abnormal_olfactory_system1.37362816
25MP0005394_taste/olfaction_phenotype1.37362816
26MP0008995_early_reproductive_senescence1.29142386
27MP0010368_abnormal_lymphatic_system1.29056093
28MP0005058_abnormal_lysosome_morphology1.28724305
29MP0001664_abnormal_digestion1.27111814
30MP0002249_abnormal_larynx_morphology1.23059027
31MP0009697_abnormal_copulation1.20661071
32MP0005395_other_phenotype1.19947241
33MP0000537_abnormal_urethra_morphology1.19547171
34MP0001348_abnormal_lacrimal_gland1.17523550
35MP0002127_abnormal_cardiovascular_syste1.16185380
36MP0005248_abnormal_Harderian_gland1.12848086
37MP0001485_abnormal_pinna_reflex1.12648657
38MP0005389_reproductive_system_phenotype1.10751675
39MP0003879_abnormal_hair_cell1.06163919
40MP0000538_abnormal_urinary_bladder1.04630330
41MP0001188_hyperpigmentation1.01581082
42MP0003646_muscle_fatigue0.98186895
43MP0005187_abnormal_penis_morphology0.95137620
44MP0001486_abnormal_startle_reflex0.93340033
45MP0002282_abnormal_trachea_morphology0.92178404
46MP0004085_abnormal_heartbeat0.91368005
47MP0004859_abnormal_synaptic_plasticity0.90513381
48MP0003632_abnormal_nervous_system0.90170626
49MP0005253_abnormal_eye_physiology0.88982079
50MP0001501_abnormal_sleep_pattern0.85143494
51MP0006072_abnormal_retinal_apoptosis0.84234070
52MP0003936_abnormal_reproductive_system0.81827123
53MP0002822_catalepsy0.80635881
54MP0002138_abnormal_hepatobiliary_system0.79730954
55MP0001963_abnormal_hearing_physiology0.77859113
56MP0003631_nervous_system_phenotype0.77168835
57MP0001968_abnormal_touch/_nociception0.76617640
58MP0002168_other_aberrant_phenotype0.75656055
59MP0000470_abnormal_stomach_morphology0.75544997
60MP0001849_ear_inflammation0.73082250
61MP0004084_abnormal_cardiac_muscle0.72586100
62MP0000026_abnormal_inner_ear0.72240239
63MP0005423_abnormal_somatic_nervous0.66520216
64MP0000534_abnormal_ureter_morphology0.66012558
65MP0004036_abnormal_muscle_relaxation0.64096976
66MP0004742_abnormal_vestibular_system0.64070831
67MP0005551_abnormal_eye_electrophysiolog0.63261569
68MP0002272_abnormal_nervous_system0.61696108
69MP0000230_abnormal_systemic_arterial0.59394128
70MP0000049_abnormal_middle_ear0.58281453
71MP0001270_distended_abdomen0.55568742
72MP0005646_abnormal_pituitary_gland0.55298078
73MP0005451_abnormal_body_composition0.55239619
74MP0005409_darkened_coat_color0.55231044
75MP0003633_abnormal_nervous_system0.55173231
76MP0009115_abnormal_fat_cell0.55150293
77MP0008789_abnormal_olfactory_epithelium0.54684144
78MP0001765_abnormal_ion_homeostasis0.53769049
79MP0006036_abnormal_mitochondrial_physio0.52941336
80MP0001919_abnormal_reproductive_system0.52837458
81MP0002067_abnormal_sensory_capabilities0.52589359
82MP0000681_abnormal_thyroid_gland0.52312495
83MP0002229_neurodegeneration0.51763263
84MP0005595_abnormal_vascular_smooth0.51749060
85MP0000465_gastrointestinal_hemorrhage0.48084963
86MP0001529_abnormal_vocalization0.47847308
87MP0004484_altered_response_of0.47726362
88MP0000955_abnormal_spinal_cord0.46443262
89MP0002735_abnormal_chemical_nociception0.46287761
90MP0000343_altered_response_to0.45959796
91MP0003635_abnormal_synaptic_transmissio0.45747437
92MP0003011_delayed_dark_adaptation0.45575946
93MP0008877_abnormal_DNA_methylation0.43526144
94MP0005379_endocrine/exocrine_gland_phen0.43488315
95MP0005391_vision/eye_phenotype0.43122590
96MP0002557_abnormal_social/conspecific_i0.42687442
97MP0005166_decreased_susceptibility_to0.40490453
98MP0000631_abnormal_neuroendocrine_gland0.39131476
99MP0005167_abnormal_blood-brain_barrier0.37227225
100MP0002572_abnormal_emotion/affect_behav0.37190635

Predicted human phenotypes

RankGene SetZ-score
1Resting tremor (HP:0002322)7.74804251
2Dynein arm defect of respiratory motile cilia (HP:0012255)7.04858946
3Absent/shortened dynein arms (HP:0200106)7.04858946
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.59027707
5Abnormal respiratory motile cilium physiology (HP:0012261)6.18380689
6Abnormal ciliary motility (HP:0012262)6.03545426
7Sex reversal (HP:0012245)5.95129698
8Abnormal sex determination (HP:0012244)5.95129698
9Infertility (HP:0000789)5.35426174
10Abnormal respiratory epithelium morphology (HP:0012253)5.24351140
11Abnormal respiratory motile cilium morphology (HP:0005938)5.24351140
12Hypoplasia of the uterus (HP:0000013)5.12577697
13Postural instability (HP:0002172)4.94469508
14Tubulointerstitial nephritis (HP:0001970)4.42526557
15Nasal polyposis (HP:0100582)4.41178242
16Severe visual impairment (HP:0001141)4.30176281
17Gonadal dysgenesis (HP:0000133)4.07004892
18Aplasia/hypoplasia of the uterus (HP:0008684)3.84090837
19Abnormality of the columella (HP:0009929)3.80298121
20Colitis (HP:0002583)3.79282244
21Chronic hepatic failure (HP:0100626)3.79033527
22Abnormality of the nasal mucosa (HP:0000433)3.75203378
23Rhinitis (HP:0012384)3.62237287
24Male pseudohermaphroditism (HP:0000037)3.49898745
25Cerebellar dysplasia (HP:0007033)3.41903700
26Reduced antithrombin III activity (HP:0001976)3.41642543
27Bony spicule pigmentary retinopathy (HP:0007737)3.36117482
28Abnormality of macular pigmentation (HP:0008002)3.29245570
29Germ cell neoplasia (HP:0100728)3.27923097
30Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.21351103
31Attenuation of retinal blood vessels (HP:0007843)3.18993336
32Abnormal rod and cone electroretinograms (HP:0008323)2.95194758
33Ventricular fibrillation (HP:0001663)2.95047302
34Type II lissencephaly (HP:0007260)2.89310611
35Male infertility (HP:0003251)2.83561448
36Chronic bronchitis (HP:0004469)2.81798562
37Asymmetric septal hypertrophy (HP:0001670)2.75236727
38Occipital encephalocele (HP:0002085)2.68586184
39Facial hemangioma (HP:0000329)2.66669855
40Bronchiectasis (HP:0002110)2.66372606
41Atonic seizures (HP:0010819)2.65841153
42Thoracolumbar scoliosis (HP:0002944)2.62585249
43Congenital sensorineural hearing impairment (HP:0008527)2.61618679
44Hyperkalemia (HP:0002153)2.58679221
45Retinal atrophy (HP:0001105)2.56925514
46Retinal dysplasia (HP:0007973)2.52874687
47Sensory axonal neuropathy (HP:0003390)2.50004046
48Renal dysplasia (HP:0000110)2.47434297
49Impulsivity (HP:0100710)2.46220747
50Bell-shaped thorax (HP:0001591)2.45800785
51Self-mutilation (HP:0000742)2.45202869
52Inflammation of the large intestine (HP:0002037)2.33921112
53Thoracic kyphosis (HP:0002942)2.33419163
54Anterior segment dysgenesis (HP:0007700)2.28470245
55Urinary urgency (HP:0000012)2.27128079
56Flattened epiphyses (HP:0003071)2.24010165
57Optic nerve hypoplasia (HP:0000609)2.22611951
58Facial shape deformation (HP:0011334)2.18772987
59Potter facies (HP:0002009)2.18772987
60Polydipsia (HP:0001959)2.18711824
61Abnormal drinking behavior (HP:0030082)2.18711824
62Cone-rod dystrophy (HP:0000548)2.18505516
63Azoospermia (HP:0000027)2.15060495
64Gastrointestinal inflammation (HP:0004386)2.10861728
65Aplasia/Hypoplasia of the earlobes (HP:0009906)2.10231690
66Abnormality of dental color (HP:0011073)2.09800519
67Hypoplasia of the thymus (HP:0000778)2.06698848
68Abnormal urine output (HP:0012590)1.99044561
69Abnormal spermatogenesis (HP:0008669)1.98983260
70Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.98695703
71Hypoalphalipoproteinemia (HP:0003233)1.98202824
72Buphthalmos (HP:0000557)1.94820287
73Protruding tongue (HP:0010808)1.88530903
74Renovascular hypertension (HP:0100817)1.87819851
75Abnormality of the lumbar spine (HP:0100712)1.86775550
76Recurrent corneal erosions (HP:0000495)1.84680644
77Hypoplastic ischia (HP:0003175)1.83050422
78Progressive sensorineural hearing impairment (HP:0000408)1.76734682
79Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.76571263
80Tubulointerstitial abnormality (HP:0001969)1.76507703
81Atrial fibrillation (HP:0005110)1.76413392
82Chronic sinusitis (HP:0011109)1.74835342
83Menstrual irregularities (HP:0000858)1.74166220
84Inability to walk (HP:0002540)1.73873932
85Abnormality of the intrinsic pathway (HP:0010989)1.73153610
86Truncal obesity (HP:0001956)1.72930812
87Abnormality of the ischium (HP:0003174)1.71586705
88Bradykinesia (HP:0002067)1.71351139
89Abnormality of male internal genitalia (HP:0000022)1.71233621
90Polyuria (HP:0000103)1.70971856
91Abnormality of renal excretion (HP:0011036)1.68856981
92Absent rod-and cone-mediated responses on ERG (HP:0007688)1.67923297
93Photophobia (HP:0000613)1.67715347
94Rhabdomyolysis (HP:0003201)1.66128933
95Progressive cerebellar ataxia (HP:0002073)1.65790474
96Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.64947911
97Capillary hemangiomas (HP:0005306)1.64926550
98Type II diabetes mellitus (HP:0005978)1.64430517
99Absent thumb (HP:0009777)1.59416668
100Primary atrial arrhythmia (HP:0001692)1.58927681

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK35.17887438
2PLK44.25977271
3TLK13.23703272
4ZAK3.22009628
5STK383.00632241
6MYLK2.65199357
7RPS6KA52.36763613
8STK38L2.29272230
9TESK12.26756232
10PINK110.1869020
11LATS11.94137434
12NEK21.93677703
13MAPK151.92732006
14DDR21.90089145
15INSRR1.74540379
16MST1R1.73633152
17BRD41.58037406
18PRKD31.46631043
19PNCK1.38707974
20PLK21.34204856
21MAP4K21.25298943
22CAMK1G1.22265525
23CDK31.21947882
24LATS21.20741278
25MAP3K91.14865492
26SGK4941.12278089
27SGK2231.12278089
28MAP2K71.08525689
29PDPK11.07565470
30PDK10.92685174
31FRK0.80550541
32BMPR1B0.79249895
33ARAF0.79241287
34PTK2B0.78819543
35CDK120.78063530
36WNK10.75527597
37PIK3CG0.73286672
38PRKCQ0.71697350
39PRKG20.71147614
40DYRK30.68535530
41MAP3K10.65862240
42VRK10.65042843
43ROCK10.60814148
44CDK140.60456515
45NEK60.59266491
46CAMK10.59006492
47TIE10.56784459
48PRKG10.56542538
49BRAF0.54210102
50OBSCN0.52530503
51CDC42BPA0.50089079
52KSR20.49299656
53AKT30.48010497
54MAP3K130.46494379
55TYRO30.46244092
56CSNK1A1L0.45268704
57PKN10.44823500
58RPS6KA10.44643905
59FGFR20.42894885
60PAK20.41337856
61PAK10.41072187
62CDK70.40417418
63DYRK20.39858088
64CAMK1D0.39125645
65DYRK1B0.35599304
66MTOR0.34934421
67CSNK1G30.32638495
68CDK50.32235124
69MAPK10.30221259
70SGK20.27249541
71RPS6KA20.26332940
72SIK20.24166257
73ATM0.23870838
74MET0.23128774
75RET0.21990607
76ADRBK20.21623862
77GSK3B0.21292361
78FGR0.20911391
79MOS0.20601367
80EGFR0.20363537
81MELK0.19126638
82ICK0.18350167
83CSNK1G10.17978904
84CSNK1G20.17864086
85MAP3K20.17346939
86TGFBR10.16928924
87MAP3K80.16804273
88RPS6KA30.16441345
89CSNK1A10.15718032
90DAPK30.15299621
91CDK10.14041791
92MINK10.13458785
93CAMK40.12996886
94STK390.12925829
95WNK40.12738558
96SGK10.12220658
97RPS6KB10.12152987
98PRKAA20.11892879
99EEF2K0.10263098
100MAP3K100.10087900

Predicted pathways (KEGG)

RankGene SetZ-score
1Pathogenic Escherichia coli infection_Homo sapiens_hsa051306.22809566
2Gap junction_Homo sapiens_hsa045404.41437605
3Fatty acid biosynthesis_Homo sapiens_hsa000614.13619443
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.97806358
5Olfactory transduction_Homo sapiens_hsa047403.24060592
6Hedgehog signaling pathway_Homo sapiens_hsa043403.16346971
7Nitrogen metabolism_Homo sapiens_hsa009102.89139045
8Systemic lupus erythematosus_Homo sapiens_hsa053222.59780946
9Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.55597107
10Arginine biosynthesis_Homo sapiens_hsa002202.49692276
11Butanoate metabolism_Homo sapiens_hsa006502.42604365
12Phagosome_Homo sapiens_hsa041452.28584720
13Apoptosis_Homo sapiens_hsa042102.26163606
14Alcoholism_Homo sapiens_hsa050342.04650776
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.93996801
16Dorso-ventral axis formation_Homo sapiens_hsa043201.87129482
17Propanoate metabolism_Homo sapiens_hsa006401.61610092
18Glycerophospholipid metabolism_Homo sapiens_hsa005641.36906015
19Phenylalanine metabolism_Homo sapiens_hsa003601.35892983
20Fatty acid degradation_Homo sapiens_hsa000711.35169903
21Taste transduction_Homo sapiens_hsa047421.34644162
22PPAR signaling pathway_Homo sapiens_hsa033201.15446233
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.09487867
24Vascular smooth muscle contraction_Homo sapiens_hsa042701.00313310
25Oocyte meiosis_Homo sapiens_hsa041140.99233864
26Pyruvate metabolism_Homo sapiens_hsa006200.99066910
27Glutathione metabolism_Homo sapiens_hsa004800.96524254
28Fatty acid metabolism_Homo sapiens_hsa012120.95472193
29Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.95401931
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94163012
31RNA transport_Homo sapiens_hsa030130.87406920
32cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84866260
33Renin secretion_Homo sapiens_hsa049240.83545320
34Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78515406
35Glucagon signaling pathway_Homo sapiens_hsa049220.78350457
36Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74633674
37Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.71933596
38Chemical carcinogenesis_Homo sapiens_hsa052040.69416797
39Calcium signaling pathway_Homo sapiens_hsa040200.67040787
40Gastric acid secretion_Homo sapiens_hsa049710.66050785
41Oxytocin signaling pathway_Homo sapiens_hsa049210.64922271
42Tyrosine metabolism_Homo sapiens_hsa003500.61590736
43Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61198484
44Type II diabetes mellitus_Homo sapiens_hsa049300.61134884
45Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60923069
46mRNA surveillance pathway_Homo sapiens_hsa030150.57149110
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55344149
48Circadian entrainment_Homo sapiens_hsa047130.55089186
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54988712
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51629458
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50813465
52Purine metabolism_Homo sapiens_hsa002300.50515983
53Basal transcription factors_Homo sapiens_hsa030220.50368565
54Estrogen signaling pathway_Homo sapiens_hsa049150.49130264
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48003543
56Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47429858
57Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46587375
58Adipocytokine signaling pathway_Homo sapiens_hsa049200.45683687
59Arginine and proline metabolism_Homo sapiens_hsa003300.44595343
60Synaptic vesicle cycle_Homo sapiens_hsa047210.44324338
61Circadian rhythm_Homo sapiens_hsa047100.44122165
62Tryptophan metabolism_Homo sapiens_hsa003800.43669977
63Phototransduction_Homo sapiens_hsa047440.43270289
64Salivary secretion_Homo sapiens_hsa049700.42652739
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.41260913
66Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40622611
67cAMP signaling pathway_Homo sapiens_hsa040240.38672531
68Protein digestion and absorption_Homo sapiens_hsa049740.37674712
69Glycerolipid metabolism_Homo sapiens_hsa005610.36787030
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.35554258
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.35230550
72Fanconi anemia pathway_Homo sapiens_hsa034600.34896636
73MAPK signaling pathway_Homo sapiens_hsa040100.33808334
74Long-term potentiation_Homo sapiens_hsa047200.32372943
75Retinol metabolism_Homo sapiens_hsa008300.31466524
76Inositol phosphate metabolism_Homo sapiens_hsa005620.30741420
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30228661
78Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.29343960
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28699464
80Endocytosis_Homo sapiens_hsa041440.27501720
81beta-Alanine metabolism_Homo sapiens_hsa004100.27231137
82Choline metabolism in cancer_Homo sapiens_hsa052310.26960494
83ECM-receptor interaction_Homo sapiens_hsa045120.26018747
84Morphine addiction_Homo sapiens_hsa050320.25646652
85VEGF signaling pathway_Homo sapiens_hsa043700.25449668
86Glutamatergic synapse_Homo sapiens_hsa047240.25418688
87Aldosterone synthesis and secretion_Homo sapiens_hsa049250.24837994
88TGF-beta signaling pathway_Homo sapiens_hsa043500.22795702
89Biosynthesis of amino acids_Homo sapiens_hsa012300.22406849
90Nicotine addiction_Homo sapiens_hsa050330.22193426
91Wnt signaling pathway_Homo sapiens_hsa043100.22136103
92Influenza A_Homo sapiens_hsa051640.21784937
93Tight junction_Homo sapiens_hsa045300.21591704
94Carbon metabolism_Homo sapiens_hsa012000.21571886
95B cell receptor signaling pathway_Homo sapiens_hsa046620.21500104
96Metabolic pathways_Homo sapiens_hsa011000.21028187
97Viral carcinogenesis_Homo sapiens_hsa052030.20520738
98Prostate cancer_Homo sapiens_hsa052150.20496905
99Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.18857412
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.18203631

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