C16ORF72

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytoplasmic mRNA processing body assembly (GO:0033962)4.68483751
2phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.08721455
3histone H3-K36 demethylation (GO:0070544)4.04915075
4negative regulation of translation, ncRNA-mediated (GO:0040033)3.70843368
5regulation of translation, ncRNA-mediated (GO:0045974)3.70843368
6negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.70843368
7protein K11-linked deubiquitination (GO:0035871)3.65175119
8monoubiquitinated protein deubiquitination (GO:0035520)3.46833200
9hepatocyte apoptotic process (GO:0097284)3.41283167
10positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.37058463
11detection of molecule of bacterial origin (GO:0032490)3.36754064
12neural tube formation (GO:0001841)3.35083288
13histone H3-K4 trimethylation (GO:0080182)3.31029122
14regulation of B cell receptor signaling pathway (GO:0050855)3.27910280
15positive regulation of gamma-delta T cell activation (GO:0046645)3.22350293
16cellular extravasation (GO:0045123)3.19069235
17negative regulation of T-helper cell differentiation (GO:0045623)3.18529998
18negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.18529998
19establishment of protein localization to Golgi (GO:0072600)3.09834015
20nuclear pore complex assembly (GO:0051292)3.04238980
21cellular response to ethanol (GO:0071361)2.93620409
22interkinetic nuclear migration (GO:0022027)2.87075970
23negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.85352842
24regulation of oxidative stress-induced neuron death (GO:1903203)2.84948386
25protein targeting to Golgi (GO:0000042)2.83882998
26histone mRNA catabolic process (GO:0071044)2.81737221
27peptidyl-lysine trimethylation (GO:0018023)2.78713343
28nuclear pore organization (GO:0006999)2.75951137
29retrograde transport, vesicle recycling within Golgi (GO:0000301)2.74609194
30histone demethylation (GO:0016577)2.73440117
31histone lysine demethylation (GO:0070076)2.72940766
32regulation of gamma-delta T cell activation (GO:0046643)2.72674728
33regulation of establishment of cell polarity (GO:2000114)2.64656512
34N-terminal protein amino acid acetylation (GO:0006474)2.63492816
35regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.61933925
36positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.61933925
37regulation of gamma-delta T cell differentiation (GO:0045586)2.60814248
38protein K63-linked deubiquitination (GO:0070536)2.60584568
39definitive hemopoiesis (GO:0060216)2.57441340
40positive T cell selection (GO:0043368)2.55949838
41pre-miRNA processing (GO:0031054)2.53757249
42phospholipid translocation (GO:0045332)2.53223558
43lipid translocation (GO:0034204)2.53223558
44nucleus localization (GO:0051647)2.53089361
45regulation of Rac protein signal transduction (GO:0035020)2.51184269
46TOR signaling (GO:0031929)2.50498515
47protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.50073082
48fibroblast migration (GO:0010761)2.49043716
49B cell receptor signaling pathway (GO:0050853)2.46161197
50positive regulation of granulocyte differentiation (GO:0030854)2.46097180
51establishment of nucleus localization (GO:0040023)2.43647776
52positive regulation of mRNA catabolic process (GO:0061014)2.43061847
53regulation of pigment cell differentiation (GO:0050932)2.42630718
54regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.37804905
55protein K48-linked deubiquitination (GO:0071108)2.36945648
56histone H3-K4 methylation (GO:0051568)2.36594694
57platelet-derived growth factor receptor signaling pathway (GO:0048008)2.35885757
58T-helper cell differentiation (GO:0042093)2.35691640
59CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.35691640
60positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.35356735
61regulation of phosphoprotein phosphatase activity (GO:0043666)2.35128592
62peptidyl-threonine phosphorylation (GO:0018107)2.35075365
63response to interleukin-15 (GO:0070672)2.34973598
64negative regulation of alpha-beta T cell differentiation (GO:0046639)2.33642379
65neutrophil mediated immunity (GO:0002446)2.33249886
66negative regulation of neurotransmitter secretion (GO:0046929)2.31153645
67interleukin-6-mediated signaling pathway (GO:0070102)2.31049208
68activated T cell proliferation (GO:0050798)2.30966735
69myeloid leukocyte mediated immunity (GO:0002444)2.30712855
70production of molecular mediator involved in inflammatory response (GO:0002532)2.30016954
71positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.29320386
72regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.29320386
73prenylation (GO:0097354)2.29211654
74protein prenylation (GO:0018342)2.29211654
75positive regulation by symbiont of host defense response (GO:0052509)2.28935270
76modulation by symbiont of host defense response (GO:0052031)2.28935270
77modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.28935270
78modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.28935270
79positive regulation by organism of defense response of other organism involved in symbiotic interact2.28935270
80modulation by symbiont of host immune response (GO:0052553)2.28935270
81protein dealkylation (GO:0008214)2.28906709
82protein demethylation (GO:0006482)2.28906709
83regulation of fibroblast apoptotic process (GO:2000269)2.28657231
84regulation of mRNA catabolic process (GO:0061013)2.25723717
85antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.24951168
86histone H3-K9 demethylation (GO:0033169)2.24882010
87Rap protein signal transduction (GO:0032486)2.24842085
88negative thymic T cell selection (GO:0045060)2.24771595
89negative T cell selection (GO:0043383)2.24676711
90mitotic sister chromatid cohesion (GO:0007064)2.23663506
91macrophage activation involved in immune response (GO:0002281)2.23294919
92negative regulation of B cell proliferation (GO:0030889)2.23253187
93peptidyl-threonine modification (GO:0018210)2.23176456
94microglial cell activation (GO:0001774)2.20911377
95negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.19927952
96negative regulation of cell killing (GO:0031342)2.19927952
97detection of external biotic stimulus (GO:0098581)2.19859781
98macrophage activation (GO:0042116)2.19636478
99genitalia morphogenesis (GO:0035112)2.19539540
100growth hormone receptor signaling pathway (GO:0060396)2.18454519

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.22551736
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.56229869
3SMAD_19615063_ChIP-ChIP_OVARY_Human3.45940540
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.15580311
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.14496040
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.63650178
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.45814571
8GBX2_23144817_ChIP-Seq_PC3_Human2.37431634
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.17666944
10AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.98813333
11ZNF217_24962896_ChIP-Seq_MCF-7_Human1.94385410
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.89365729
13SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.89072030
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.87583498
15ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86658820
16IGF1R_20145208_ChIP-Seq_DFB_Human1.86625440
17IRF8_22096565_ChIP-ChIP_GC-B_Human1.81606325
18CDX2_19796622_ChIP-Seq_MESCs_Mouse1.78750612
19ER_23166858_ChIP-Seq_MCF-7_Human1.70589406
20TAF15_26573619_Chip-Seq_HEK293_Human1.70224976
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.62371600
22ESR1_20079471_ChIP-ChIP_T-47D_Human1.61632557
23AHR_22903824_ChIP-Seq_MCF-7_Human1.60739369
24RUNX_20019798_ChIP-Seq_JUKART_Human1.60646409
25AR_21572438_ChIP-Seq_LNCaP_Human1.58665681
26ARNT_22903824_ChIP-Seq_MCF-7_Human1.56732253
27PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54808405
28TP53_16413492_ChIP-PET_HCT116_Human1.54434637
29SMAD4_21799915_ChIP-Seq_A2780_Human1.52149454
30* P300_19829295_ChIP-Seq_ESCs_Human1.51037575
31FUS_26573619_Chip-Seq_HEK293_Human1.49274017
32VDR_24787735_ChIP-Seq_THP-1_Human1.48557386
33CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.47684261
34OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46615848
35PIAS1_25552417_ChIP-Seq_VCAP_Human1.44886018
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.43095600
37MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42377748
38Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.42329756
39STAT3_23295773_ChIP-Seq_U87_Human1.41741466
40FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.39232992
41* EWS_26573619_Chip-Seq_HEK293_Human1.38203388
42WT1_19549856_ChIP-ChIP_CCG9911_Human1.37559278
43VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.37436554
44TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37296212
45POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37296212
46SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33934653
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32267784
48FOXM1_26456572_ChIP-Seq_MCF-7_Human1.29138981
49ZNF274_21170338_ChIP-Seq_K562_Hela1.28383711
50GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.28240325
51PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27656907
52FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24301653
53BRD4_25478319_ChIP-Seq_HGPS_Human1.24240194
54NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.23312571
55NRF2_20460467_ChIP-Seq_MEFs_Mouse1.23312571
56EGR1_19374776_ChIP-ChIP_THP-1_Human1.23012546
57* NOTCH1_21737748_ChIP-Seq_TLL_Human1.22939296
58TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.22827137
59UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21819596
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20790741
61CBP_20019798_ChIP-Seq_JUKART_Human1.20790741
62BCAT_22108803_ChIP-Seq_LS180_Human1.20156696
63CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19633004
64* SMAD3_21741376_ChIP-Seq_EPCs_Human1.19040248
65TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18101973
66FOXO3_23340844_ChIP-Seq_DLD1_Human1.16816799
67GATA1_22025678_ChIP-Seq_K562_Human1.16557400
68* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16165187
69IRF8_27001747_Chip-Seq_BMDM_Mouse1.16132067
70RXR_22108803_ChIP-Seq_LS180_Human1.15921330
71TCF4_23295773_ChIP-Seq_U87_Human1.15544621
72EZH2_27294783_Chip-Seq_NPCs_Mouse1.15418718
73CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15139113
74VDR_22108803_ChIP-Seq_LS180_Human1.15077129
75NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.12935550
76SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.12461169
77NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11764324
78PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11218017
79RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.10700129
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.10504090
81MYB_21317192_ChIP-Seq_ERMYB_Mouse1.09764499
82PRDM14_20953172_ChIP-Seq_ESCs_Human1.09763109
83CTNNB1_20460455_ChIP-Seq_HCT116_Human1.09579874
84MYB_26560356_Chip-Seq_TH2_Human1.08976341
85FLI1_21867929_ChIP-Seq_TH2_Mouse1.08241796
86* CJUN_26792858_Chip-Seq_BT549_Human1.07357698
87ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.05952280
88SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05576154
89CDX2_22108803_ChIP-Seq_LS180_Human1.05124629
90PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03471231
91RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03390221
92* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01532632
93KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.99470459
94AR_25329375_ChIP-Seq_VCAP_Human0.99346435
95BP1_19119308_ChIP-ChIP_Hs578T_Human0.97769298
96NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.96250752
97EP300_21415370_ChIP-Seq_HL-1_Mouse0.95999191
98STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.95637992
99E2F1_18555785_Chip-Seq_ESCs_Mouse0.95415525
100* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95045882

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.19371121
2MP0000569_abnormal_digit_pigmentation4.86965388
3MP0002009_preneoplasia4.47204453
4MP0003828_pulmonary_edema3.01063725
5MP0003724_increased_susceptibility_to2.97423984
6MP0002166_altered_tumor_susceptibility2.64361586
7MP0010352_gastrointestinal_tract_polyps2.62085245
8MP0010234_abnormal_vibrissa_follicle2.41321125
9MP0003763_abnormal_thymus_physiology2.39549033
10MP0004484_altered_response_of2.25969044
11MP0004084_abnormal_cardiac_muscle2.20481159
12MP0003787_abnormal_imprinting2.05509522
13MP0004381_abnormal_hair_follicle2.02917139
14MP0003300_gastrointestinal_ulcer1.97667182
15MP0008877_abnormal_DNA_methylation1.90489500
16MP0005409_darkened_coat_color1.86592955
17MP0003045_fibrosis1.85263096
18MP0002396_abnormal_hematopoietic_system1.72776284
19MP0004808_abnormal_hematopoietic_stem1.70534606
20MP0001835_abnormal_antigen_presentation1.69097144
21MP0002006_tumorigenesis1.67461683
22MP0003091_abnormal_cell_migration1.59916988
23MP0010678_abnormal_skin_adnexa1.58490282
24MP0000427_abnormal_hair_cycle1.52646561
25MP0005187_abnormal_penis_morphology1.52231786
26MP0005076_abnormal_cell_differentiation1.50415696
27MP0003890_abnormal_embryonic-extraembry1.49118084
28MP0004883_abnormal_blood_vessel1.47689552
29MP0008961_abnormal_basal_metabolism1.47376143
30MP0001800_abnormal_humoral_immune1.47065872
31MP0003221_abnormal_cardiomyocyte_apopto1.44713433
32MP0004130_abnormal_muscle_cell1.43235281
33MP0006054_spinal_hemorrhage1.42559740
34MP0004036_abnormal_muscle_relaxation1.40680580
35MP0008004_abnormal_stomach_pH1.37097353
36MP0004264_abnormal_extraembryonic_tissu1.36448034
37MP0000685_abnormal_immune_system1.32983727
38MP0005248_abnormal_Harderian_gland1.30411831
39MP0000703_abnormal_thymus_morphology1.29719095
40MP0002332_abnormal_exercise_endurance1.22465679
41MP0000465_gastrointestinal_hemorrhage1.22210272
42MP0005174_abnormal_tail_pigmentation1.19650359
43MP0000383_abnormal_hair_follicle1.11367482
44MP0010307_abnormal_tumor_latency1.10103899
45MP0002405_respiratory_system_inflammati1.09898777
46MP0002420_abnormal_adaptive_immunity1.09658492
47MP0002168_other_aberrant_phenotype1.09562392
48MP0002398_abnormal_bone_marrow1.09170140
49MP0002127_abnormal_cardiovascular_syste1.09132042
50MP0001819_abnormal_immune_cell1.05014574
51MP0003656_abnormal_erythrocyte_physiolo1.04759321
52MP0002419_abnormal_innate_immunity1.01156624
53MP0009115_abnormal_fat_cell0.98791212
54MP0005367_renal/urinary_system_phenotyp0.98616127
55MP0000516_abnormal_urinary_system0.98616127
56MP0002452_abnormal_antigen_presenting0.98449777
57MP0002722_abnormal_immune_system0.96306708
58MP0002723_abnormal_immune_serum0.94861447
59MP0000689_abnormal_spleen_morphology0.94665722
60MP0002928_abnormal_bile_duct0.94560494
61MP0000015_abnormal_ear_pigmentation0.93388833
62MP0003303_peritoneal_inflammation0.92224604
63MP0000716_abnormal_immune_system0.91885773
64MP0001851_eye_inflammation0.89572464
65MP0005164_abnormal_response_to0.89124932
66MP0000767_abnormal_smooth_muscle0.88351160
67MP0001177_atelectasis0.84731083
68MP0003252_abnormal_bile_duct0.82995925
69MP0001784_abnormal_fluid_regulation0.82843065
70MP0005000_abnormal_immune_tolerance0.82687184
71MP0002138_abnormal_hepatobiliary_system0.81894990
72MP0003943_abnormal_hepatobiliary_system0.81826406
73MP0002133_abnormal_respiratory_system0.80833283
74MP0005388_respiratory_system_phenotype0.80833283
75MP0000470_abnormal_stomach_morphology0.79416601
76MP0009703_decreased_birth_body0.78868299
77MP0003195_calcinosis0.78732890
78MP0002998_abnormal_bone_remodeling0.78243647
79MP0002086_abnormal_extraembryonic_tissu0.76894337
80MP0005310_abnormal_salivary_gland0.75867623
81MP0001790_abnormal_immune_system0.75298740
82MP0005387_immune_system_phenotype0.75298740
83MP0001188_hyperpigmentation0.74634548
84MP0005647_abnormal_sex_gland0.73184466
85MP0001879_abnormal_lymphatic_vessel0.72398226
86MP0004947_skin_inflammation0.70018531
87MP0003436_decreased_susceptibility_to0.69336259
88MP0002102_abnormal_ear_morphology0.68086473
89MP0003868_abnormal_feces_composition0.67956964
90MP0002925_abnormal_cardiovascular_devel0.67334176
91MP0004197_abnormal_fetal_growth/weight/0.66387734
92MP0005620_abnormal_muscle_contractility0.65452709
93MP0002088_abnormal_embryonic_growth/wei0.65115679
94MP0001915_intracranial_hemorrhage0.65055463
95MP0010630_abnormal_cardiac_muscle0.64597995
96MP0009697_abnormal_copulation0.63235953
97MP0003646_muscle_fatigue0.61100911
98MP0003935_abnormal_craniofacial_develop0.61091409
99MP0006138_congestive_heart_failure0.60272054
100MP0000733_abnormal_muscle_development0.60177802

Predicted human phenotypes

RankGene SetZ-score
1Curly hair (HP:0002212)3.11817763
2Papillary thyroid carcinoma (HP:0002895)3.11129009
3T lymphocytopenia (HP:0005403)2.85281231
4Genetic anticipation (HP:0003743)2.81021921
5Abnormality of T cell number (HP:0011839)2.75673795
6Thyroiditis (HP:0100646)2.74712884
7Subacute progressive viral hepatitis (HP:0006572)2.70361484
8Hematochezia (HP:0002573)2.67252563
9Abnormality of the fingertips (HP:0001211)2.66346344
10Protruding tongue (HP:0010808)2.61181518
11Narrow palate (HP:0000189)2.60673800
12Fair hair (HP:0002286)2.59869225
13Hyperventilation (HP:0002883)2.59178675
14Hyporeflexia of lower limbs (HP:0002600)2.55639656
15Widely spaced teeth (HP:0000687)2.51558709
16Acute myeloid leukemia (HP:0004808)2.48571023
17Eosinophilia (HP:0001880)2.42129392
18Stomatitis (HP:0010280)2.40951881
19Truncal obesity (HP:0001956)2.37385953
20Gaze-evoked nystagmus (HP:0000640)2.36096054
21Difficulty running (HP:0009046)2.35688198
22Febrile seizures (HP:0002373)2.32237102
23Retrobulbar optic neuritis (HP:0100654)2.29679344
24Optic neuritis (HP:0100653)2.29679344
25Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.29607596
26Neoplasm of the tracheobronchial system (HP:0100552)2.28438426
27Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.27904572
28Abnormal delayed hypersensitivity skin test (HP:0002963)2.26734586
29Abnormality of the columella (HP:0009929)2.24124102
30Transitional cell carcinoma of the bladder (HP:0006740)2.21482163
31Generalized hypopigmentation of hair (HP:0011358)2.21351025
32Aqueductal stenosis (HP:0002410)2.20963211
33Thyroid carcinoma (HP:0002890)2.18318103
34Cystic hygroma (HP:0000476)2.15336047
35Overgrowth (HP:0001548)2.14975759
36Dysmetric saccades (HP:0000641)2.12086751
37Bladder neoplasm (HP:0009725)2.11914260
38Bladder carcinoma (HP:0002862)2.11914260
39Recurrent fungal infections (HP:0002841)2.11861808
40Clumsiness (HP:0002312)2.10803614
41Stomach cancer (HP:0012126)2.09603713
42Abnormality of incisor morphology (HP:0011063)2.08162892
43Eczematoid dermatitis (HP:0000976)2.07215313
44Absent speech (HP:0001344)2.03803619
45Recurrent bacterial skin infections (HP:0005406)2.03103822
46Spontaneous hematomas (HP:0007420)2.01625597
47Abnormality of the frontal sinuses (HP:0002687)2.01019425
48Volvulus (HP:0002580)2.00119583
49Recurrent cutaneous fungal infections (HP:0011370)1.98286744
50Chronic mucocutaneous candidiasis (HP:0002728)1.98286744
51Spinal cord lesions (HP:0100561)1.97231314
52Syringomyelia (HP:0003396)1.97231314
53Prominent nose (HP:0000448)1.97042727
54Short chin (HP:0000331)1.95183431
55Abnormality of eosinophils (HP:0001879)1.94567574
56Neonatal hypoglycemia (HP:0001998)1.93202492
57Autoimmune hemolytic anemia (HP:0001890)1.92461410
58Atonic seizures (HP:0010819)1.91006566
59Orchitis (HP:0100796)1.89576578
60Leukocytosis (HP:0001974)1.89175426
61Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.88825356
62Facial diplegia (HP:0001349)1.87938068
63Submucous cleft hard palate (HP:0000176)1.85902238
64Cubitus valgus (HP:0002967)1.83910748
65Neoplasm of the adrenal cortex (HP:0100641)1.80631819
66Hypochromic microcytic anemia (HP:0004840)1.77977398
67Depressed nasal tip (HP:0000437)1.75972937
68Heterotopia (HP:0002282)1.75811064
69Viral hepatitis (HP:0006562)1.74527675
70Lip pit (HP:0100267)1.73727055
71Deep philtrum (HP:0002002)1.73441631
72Recurrent viral infections (HP:0004429)1.73392218
73Hypoplasia of the maxilla (HP:0000327)1.72557713
74Biliary tract neoplasm (HP:0100574)1.71406084
75Resting tremor (HP:0002322)1.71167525
76Low anterior hairline (HP:0000294)1.71040108
77Tapered finger (HP:0001182)1.71034006
78Alveolar cell carcinoma (HP:0006519)1.71012445
79Germ cell neoplasia (HP:0100728)1.70850749
80Abnormal pancreas size (HP:0012094)1.70748731
81Abnormal biliary tract morphology (HP:0012440)1.70706997
82Abnormality of secondary sexual hair (HP:0009888)1.70684560
83Abnormality of the axillary hair (HP:0100134)1.70684560
84Relative macrocephaly (HP:0004482)1.68831710
85Sandal gap (HP:0001852)1.68230896
86Keratoconjunctivitis sicca (HP:0001097)1.67924988
87Postural instability (HP:0002172)1.67794260
88Absent frontal sinuses (HP:0002688)1.67754058
89Asymmetry of the thorax (HP:0001555)1.67608496
90Excessive salivation (HP:0003781)1.67526247
91Cupped ear (HP:0000378)1.66884253
92Progressive cerebellar ataxia (HP:0002073)1.66412814
93Inappropriate behavior (HP:0000719)1.66357828
94Granulocytopenia (HP:0001913)1.66009096
95Myositis (HP:0100614)1.65364646
96Recurrent abscess formation (HP:0002722)1.64181541
97Drooling (HP:0002307)1.63783609
98Progressive inability to walk (HP:0002505)1.63627293
99Arterial thrombosis (HP:0004420)1.63590067
100Autoimmune thrombocytopenia (HP:0001973)1.62285505

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.64481477
2AKT33.08857070
3ACVR1B2.48110791
4PINK12.38838840
5NLK2.32453949
6BRD42.31270924
7SGK22.21022778
8MKNK21.93385877
9LATS11.84112884
10EIF2AK31.79557172
11SGK31.70233777
12FGFR31.60644903
13BMPR1B1.58074260
14MARK31.56780702
15MAP3K21.56129059
16MELK1.46874852
17BLK1.45906145
18CDK121.45877603
19TRPM71.44678365
20STK38L1.40710373
21CASK1.40333097
22YES11.40253524
23SGK2231.38046812
24SGK4941.38046812
25TNIK1.37894540
26MAP3K101.37103551
27OBSCN1.31981878
28IRAK11.27899497
29ERBB31.25780323
30FGFR21.25346323
31IRAK21.22797432
32WNK11.16821570
33STK241.13620114
34PAK31.12632302
35STK31.11961382
36JAK11.09803359
37CAMK1G1.09179815
38CAMK1D1.09062659
39PIK3CG1.08813927
40EPHA31.03220544
41HCK0.98821186
42TEC0.94086562
43BMPR20.91307098
44KSR10.89212187
45BTK0.88622011
46BRSK20.85260638
47FER0.82998711
48MAP3K140.82747764
49IRAK40.82593994
50PRPF4B0.79537399
51FES0.77953100
52PDGFRB0.77679055
53IKBKE0.77676800
54RIPK40.77321249
55EEF2K0.77214374
56CAMK40.74878820
57STK390.72577665
58TGFBR10.72046007
59TRIM280.70730203
60CSK0.69819100
61MAP3K10.67676150
62MAP2K30.67516839
63MKNK10.67027536
64CDK60.66788995
65SIK30.66368457
66JAK20.64393123
67ZAK0.64167896
68RET0.64012783
69WNK30.63808905
70CAMKK20.62986789
71RPS6KB10.61885106
72MAP3K40.61677135
73RAF10.61504892
74MAPK130.61058128
75ZAP700.59603555
76NEK60.59552009
77NUAK10.59453329
78TAOK30.58447270
79SYK0.58232547
80MAP3K70.56605925
81FGR0.56090800
82KSR20.56036021
83STK380.53855041
84SGK10.53201233
85PRKCQ0.52909455
86STK110.52199938
87MAP3K50.51296001
88EGFR0.51233466
89MAP3K130.51216490
90ITK0.51183183
91PKN20.50120021
92TGFBR20.47853040
93CDK30.44988492
94MAP3K60.44342487
95CSNK1A1L0.42761267
96PIK3CA0.41642795
97CHUK0.40708809
98OXSR10.39789401
99JAK30.39626489
100PRKAA20.39208112

Predicted pathways (KEGG)

RankGene SetZ-score
1Dorso-ventral axis formation_Homo sapiens_hsa043202.21625102
2Circadian rhythm_Homo sapiens_hsa047101.77866545
3B cell receptor signaling pathway_Homo sapiens_hsa046621.66598723
4FoxO signaling pathway_Homo sapiens_hsa040681.64978299
5T cell receptor signaling pathway_Homo sapiens_hsa046601.62315332
6Endometrial cancer_Homo sapiens_hsa052131.52474907
7Non-small cell lung cancer_Homo sapiens_hsa052231.50504013
8Phosphatidylinositol signaling system_Homo sapiens_hsa040701.46823164
9Osteoclast differentiation_Homo sapiens_hsa043801.35777790
10Prostate cancer_Homo sapiens_hsa052151.34925224
11mTOR signaling pathway_Homo sapiens_hsa041501.26211704
12Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.21881283
13NOD-like receptor signaling pathway_Homo sapiens_hsa046211.20112378
14Jak-STAT signaling pathway_Homo sapiens_hsa046301.18530473
15Platelet activation_Homo sapiens_hsa046111.18163303
16Glioma_Homo sapiens_hsa052141.17904401
17Long-term potentiation_Homo sapiens_hsa047201.17450186
18Renal cell carcinoma_Homo sapiens_hsa052111.16347254
19Chronic myeloid leukemia_Homo sapiens_hsa052201.15907870
20Colorectal cancer_Homo sapiens_hsa052101.14728160
21Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.14143738
22Measles_Homo sapiens_hsa051621.13639855
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.13556313
24Prolactin signaling pathway_Homo sapiens_hsa049171.13423826
25Hepatitis B_Homo sapiens_hsa051611.12653471
26Acute myeloid leukemia_Homo sapiens_hsa052211.12564478
27Inositol phosphate metabolism_Homo sapiens_hsa005621.12181283
28Longevity regulating pathway - mammal_Homo sapiens_hsa042111.11741282
29Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.10167121
30MicroRNAs in cancer_Homo sapiens_hsa052061.06530406
31Renin secretion_Homo sapiens_hsa049241.06511273
32cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06454966
33Type II diabetes mellitus_Homo sapiens_hsa049301.04807062
34Neurotrophin signaling pathway_Homo sapiens_hsa047221.04460039
35Oxytocin signaling pathway_Homo sapiens_hsa049211.03498183
36ErbB signaling pathway_Homo sapiens_hsa040121.01852350
37TGF-beta signaling pathway_Homo sapiens_hsa043501.01096357
38NF-kappa B signaling pathway_Homo sapiens_hsa040641.00076435
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.00021049
40TNF signaling pathway_Homo sapiens_hsa046681.00004820
41Pancreatic cancer_Homo sapiens_hsa052120.99259626
42Choline metabolism in cancer_Homo sapiens_hsa052310.97278478
43GnRH signaling pathway_Homo sapiens_hsa049120.97128339
44Leishmaniasis_Homo sapiens_hsa051400.96794029
45Tuberculosis_Homo sapiens_hsa051520.93899250
46Olfactory transduction_Homo sapiens_hsa047400.93233366
47Adherens junction_Homo sapiens_hsa045200.93232266
48Estrogen signaling pathway_Homo sapiens_hsa049150.92478760
49Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.91695300
50Insulin resistance_Homo sapiens_hsa049310.91579609
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.89334175
52MAPK signaling pathway_Homo sapiens_hsa040100.88848714
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88551166
54Sphingolipid signaling pathway_Homo sapiens_hsa040710.87826502
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86361512
56Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.84413338
57Chemokine signaling pathway_Homo sapiens_hsa040620.84373094
58Alcoholism_Homo sapiens_hsa050340.82850072
59Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.81698052
60Systemic lupus erythematosus_Homo sapiens_hsa053220.81623391
61RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.81127578
62Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.80493974
63Long-term depression_Homo sapiens_hsa047300.80472936
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79325710
65Toxoplasmosis_Homo sapiens_hsa051450.79224190
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78698725
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78534076
68Melanoma_Homo sapiens_hsa052180.77978900
69Viral carcinogenesis_Homo sapiens_hsa052030.77045937
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.76347997
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76064159
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.75327007
73Circadian entrainment_Homo sapiens_hsa047130.75057935
74Proteoglycans in cancer_Homo sapiens_hsa052050.74660850
75Influenza A_Homo sapiens_hsa051640.72522182
76Toll-like receptor signaling pathway_Homo sapiens_hsa046200.72476852
77Cholinergic synapse_Homo sapiens_hsa047250.71683883
78Thyroid cancer_Homo sapiens_hsa052160.71006336
79Legionellosis_Homo sapiens_hsa051340.70880756
80Insulin signaling pathway_Homo sapiens_hsa049100.70818539
81Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.70064043
82VEGF signaling pathway_Homo sapiens_hsa043700.69175166
83Gap junction_Homo sapiens_hsa045400.68966770
84cAMP signaling pathway_Homo sapiens_hsa040240.68374481
85Lysine degradation_Homo sapiens_hsa003100.67574826
86Apoptosis_Homo sapiens_hsa042100.65380357
87Herpes simplex infection_Homo sapiens_hsa051680.62621325
88Wnt signaling pathway_Homo sapiens_hsa043100.61625874
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61309801
90Rap1 signaling pathway_Homo sapiens_hsa040150.61011485
91Malaria_Homo sapiens_hsa051440.60689752
92Calcium signaling pathway_Homo sapiens_hsa040200.60556806
93Amphetamine addiction_Homo sapiens_hsa050310.60309921
94Focal adhesion_Homo sapiens_hsa045100.60194835
95Leukocyte transendothelial migration_Homo sapiens_hsa046700.58790539
96Hepatitis C_Homo sapiens_hsa051600.58686483
97Small cell lung cancer_Homo sapiens_hsa052220.58644028
98Ras signaling pathway_Homo sapiens_hsa040140.58636761
99AMPK signaling pathway_Homo sapiens_hsa041520.57730755
100Hedgehog signaling pathway_Homo sapiens_hsa043400.57310896

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