C16ORF71

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axoneme assembly (GO:0035082)8.88159979
2left/right pattern formation (GO:0060972)7.92256101
3regulation of cilium movement (GO:0003352)6.89588873
4primary alcohol catabolic process (GO:0034310)6.30001411
5ventricular system development (GO:0021591)5.83932570
6left/right axis specification (GO:0070986)5.57168830
7microtubule bundle formation (GO:0001578)5.53762356
8vitamin transmembrane transport (GO:0035461)5.46671676
9cellular response to ATP (GO:0071318)5.34609172
10centriole assembly (GO:0098534)5.17166051
11sperm capacitation (GO:0048240)5.14070224
12intraciliary transport (GO:0042073)5.10256519
13ethanol metabolic process (GO:0006067)5.08156592
14cilium organization (GO:0044782)4.99685391
15pyrimidine-containing compound transmembrane transport (GO:0072531)4.92971095
16cilium assembly (GO:0042384)4.85060268
17GDP-mannose metabolic process (GO:0019673)4.76057778
18diterpenoid biosynthetic process (GO:0016102)4.72546995
19response to xenobiotic stimulus (GO:0009410)4.58941527
20lung epithelium development (GO:0060428)4.56117612
21tolerance induction (GO:0002507)4.50792808
22protein localization to cilium (GO:0061512)4.47327795
23establishment of apical/basal cell polarity (GO:0035089)4.43005071
24regulation of microtubule-based movement (GO:0060632)4.32392446
25regulation of skeletal muscle contraction (GO:0014819)4.26232925
26nucleotide transmembrane transport (GO:1901679)4.24898398
27negative regulation of T cell differentiation in thymus (GO:0033085)4.17063219
28cilium morphogenesis (GO:0060271)4.15935559
29negative regulation of cell aging (GO:0090344)4.14250790
30microtubule depolymerization (GO:0007019)4.07527892
31one-carbon compound transport (GO:0019755)4.01364667
32sensory perception of taste (GO:0050909)3.96640286
33sperm motility (GO:0030317)3.93085729
34microtubule-based movement (GO:0007018)3.89029608
35adenosine receptor signaling pathway (GO:0001973)3.87054246
36establishment of monopolar cell polarity (GO:0061162)3.83538269
37establishment or maintenance of monopolar cell polarity (GO:0061339)3.83538269
38meiotic chromosome segregation (GO:0045132)3.79662566
39protein carboxylation (GO:0018214)3.77419683
40peptidyl-glutamic acid carboxylation (GO:0017187)3.77419683
41microtubule polymerization or depolymerization (GO:0031109)3.74689205
42cellular component assembly involved in morphogenesis (GO:0010927)3.72572322
43negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.67027055
44phosphatidylethanolamine biosynthetic process (GO:0006646)3.65973566
45ethanol oxidation (GO:0006069)3.62797518
46regulation of interleukin-5 production (GO:0032674)3.60436909
47glomerular epithelial cell development (GO:0072310)3.57829936
48sialylation (GO:0097503)3.56245663
49negative regulation of immunoglobulin mediated immune response (GO:0002890)3.52616312
50negative regulation of B cell mediated immunity (GO:0002713)3.52616312
51regulation of germinal center formation (GO:0002634)3.52401348
52rRNA methylation (GO:0031167)3.46434576
53cell projection assembly (GO:0030031)3.45733954
54phosphatidylcholine biosynthetic process (GO:0006656)3.43434830
55glutathione derivative biosynthetic process (GO:1901687)3.43073083
56glutathione derivative metabolic process (GO:1901685)3.43073083
57regulation of interleukin-13 production (GO:0032656)3.38169811
58DNA strand renaturation (GO:0000733)3.37272694
59negative regulation of inclusion body assembly (GO:0090084)3.33064643
60terpenoid biosynthetic process (GO:0016114)3.31796207
61retinoic acid metabolic process (GO:0042573)3.31615442
62regulation of synapse structural plasticity (GO:0051823)3.31421043
63G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.29161145
64phosphatidylethanolamine metabolic process (GO:0046337)3.27908234
65O-glycan processing (GO:0016266)3.19339364
66regulation of cytokine production involved in inflammatory response (GO:1900015)3.17927507
67sphingomyelin metabolic process (GO:0006684)3.12458753
68nucleoside diphosphate phosphorylation (GO:0006165)3.10469283
69retinol metabolic process (GO:0042572)3.09897678
70purinergic nucleotide receptor signaling pathway (GO:0035590)3.08719028
71lens fiber cell differentiation (GO:0070306)3.03425941
72negative regulation of humoral immune response (GO:0002921)2.99617822
73UV protection (GO:0009650)2.99179445
74cytoplasmic microtubule organization (GO:0031122)2.97951402
75establishment of planar polarity (GO:0001736)2.96530689
76establishment of tissue polarity (GO:0007164)2.96530689
77rRNA modification (GO:0000154)2.94137550
78cornea development in camera-type eye (GO:0061303)2.92440651
79glutathione biosynthetic process (GO:0006750)2.92008508
80positive regulation of protein kinase C signaling (GO:0090037)2.91039461
81exogenous drug catabolic process (GO:0042738)2.88194266
82primary alcohol metabolic process (GO:0034308)2.86293552
83renal absorption (GO:0070293)2.85113345
84spermatid development (GO:0007286)2.84207169
85glutathione metabolic process (GO:0006749)2.76809415
86positive regulation of tolerance induction (GO:0002645)2.76034866
87embryonic body morphogenesis (GO:0010172)2.74070084
88mitotic cell cycle arrest (GO:0071850)2.73566123
89detection of light stimulus involved in visual perception (GO:0050908)2.72581733
90detection of light stimulus involved in sensory perception (GO:0050962)2.72581733
91negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.68917970
92lateral ventricle development (GO:0021670)2.68497167
93nonribosomal peptide biosynthetic process (GO:0019184)2.66067712
94protein insertion into membrane (GO:0051205)2.61889684
95axonemal dynein complex assembly (GO:0070286)18.2036114
96cilium or flagellum-dependent cell motility (GO:0001539)16.3646430
97cilium movement (GO:0003341)12.9955390
98motile cilium assembly (GO:0044458)12.9333247
99epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)11.6144832
100epithelial cilium movement (GO:0003351)11.4919039

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.28932612
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.69385610
3* P68_20966046_ChIP-Seq_HELA_Human3.21569195
4CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human3.04240502
5VDR_21846776_ChIP-Seq_THP-1_Human2.81359270
6LXR_22292898_ChIP-Seq_THP-1_Human2.72363536
7SMC4_20622854_ChIP-Seq_HELA_Human2.65256876
8CTCF_27219007_Chip-Seq_Bcells_Human2.63304912
9E2F1_20622854_ChIP-Seq_HELA_Human2.52258962
10PHF8_20622854_ChIP-Seq_HELA_Human2.50174068
11ELF1_20517297_ChIP-Seq_JURKAT_Human2.42950127
12BCL6_27268052_Chip-Seq_Bcells_Human2.37494550
13BCOR_27268052_Chip-Seq_Bcells_Human2.35162283
14* SMAD2/3_21741376_ChIP-Seq_ESCs_Human2.28677808
15ERG_21242973_ChIP-ChIP_JURKAT_Human2.25936515
16TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.24909414
17RACK7_27058665_Chip-Seq_MCF-7_Human2.19207177
18CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.15873787
19DROSHA_22980978_ChIP-Seq_HELA_Human2.13749098
20YY1_22570637_ChIP-Seq_MALME-3M_Human2.06449195
21CTCF_20526341_ChIP-Seq_ESCs_Human2.04189801
22DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.01240356
23PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.98001367
24CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.92829726
25RARG_19884340_ChIP-ChIP_MEFs_Mouse1.90658863
26RARB_24833708_ChIP-Seq_LIVER_Mouse1.89785065
27MAF_26560356_Chip-Seq_TH2_Human1.86719556
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.84609981
29SA1_27219007_Chip-Seq_ERYTHROID_Human1.83829134
30RUNX1_27514584_Chip-Seq_MCF-7_Human1.83609588
31MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.81221541
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.77287001
33TP63_22573176_ChIP-Seq_HFKS_Human1.76707790
34CREB1_26743006_Chip-Seq_LNCaP_Human1.75341024
35RARA_24833708_ChIP-Seq_LIVER_Mouse1.71776563
36SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71530808
37RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.67792606
38TET1_21451524_ChIP-Seq_MESCs_Mouse1.62663255
39ERA_21632823_ChIP-Seq_H3396_Human1.61997792
40P300_27268052_Chip-Seq_Bcells_Human1.59482101
41CTCF_27219007_Chip-Seq_ERYTHROID_Human1.58295354
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.57573637
43FOXP1_21924763_ChIP-Seq_HESCs_Human1.56610193
44MAF_26560356_Chip-Seq_TH1_Human1.56335497
45SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.54795634
46XRN2_22483619_ChIP-Seq_HELA_Human1.54423158
47SA1_27219007_Chip-Seq_Bcells_Human1.51605835
48CTCF_21964334_Chip-Seq_Bcells_Human1.50731948
49TDRD3_21172665_ChIP-Seq_MCF-7_Human1.50189160
50SRY_22984422_ChIP-ChIP_TESTIS_Rat1.50038010
51PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.48719961
52VDR_24763502_ChIP-Seq_THP-1_Human1.48252285
53SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.47834322
54RXRA_24833708_ChIP-Seq_LIVER_Mouse1.46613038
55TP53_22127205_ChIP-Seq_IMR90_Human1.44453438
56EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.44237728
57IKZF1_21737484_ChIP-ChIP_HCT116_Human1.42389371
58P63_26484246_Chip-Seq_KERATINOCYTES_Human1.40083630
59EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.39585459
60DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.37939705
61TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.34507080
62CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.30775033
63KDM2B_26808549_Chip-Seq_SUP-B15_Human1.30252256
64OCT4_20526341_ChIP-Seq_ESCs_Human1.28167296
65MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.26413815
66PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24751059
67P53_21459846_ChIP-Seq_SAOS-2_Human1.23956920
68SOX2_21211035_ChIP-Seq_LN229_Human1.23218597
69MYC_19829295_ChIP-Seq_ESCs_Human1.20811029
70SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.20099392
71ESR1_21235772_ChIP-Seq_MCF-7_Human1.19912988
72RAD21_21589869_ChIP-Seq_MESCs_Mouse1.19747318
73SMC3_22415368_ChIP-Seq_MEFs_Mouse1.19152187
74CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.18917373
75FLI1_21867929_ChIP-Seq_CD8_Mouse1.18841136
76NANOG_20526341_ChIP-Seq_ESCs_Human1.17563171
77P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.17014037
78E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.16707161
79ETS1_21867929_ChIP-Seq_TH2_Mouse1.15963072
80CTCF_21964334_ChIP-Seq_BJAB-B_Human1.15931732
81EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.15757457
82EZH2_27294783_Chip-Seq_ESCs_Mouse1.15634553
83OCT4_19829295_ChIP-Seq_ESCs_Human1.15148414
84SOX2_27498859_Chip-Seq_STOMACH_Mouse1.12104827
85SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.11452027
86TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10977135
87BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.10959400
88FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10676114
89RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.10305122
90TAF2_19829295_ChIP-Seq_ESCs_Human1.08503581
91GATA3_21867929_ChIP-Seq_CD8_Mouse1.08057682
92KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.07137813
93FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06823189
94TP53_23651856_ChIP-Seq_MEFs_Mouse1.06583494
95TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.06328388
96* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06217082
97UTX_26944678_Chip-Seq_JUKART_Human1.00828478
98NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.00620122
99KLF5_25053715_ChIP-Seq_YYC3_Human1.00416930
100PU.1_20513432_ChIP-Seq_Bcells_Mouse0.99795330

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok6.34216935
2MP0003136_yellow_coat_color5.22826877
3MP0005171_absent_coat_pigmentation5.15687262
4MP0001986_abnormal_taste_sensitivity4.67938659
5MP0005174_abnormal_tail_pigmentation4.27643047
6MP0005423_abnormal_somatic_nervous4.21282738
7MP0002653_abnormal_ependyma_morphology3.85899815
8MP0004043_abnormal_pH_regulation3.46905584
9MP0001188_hyperpigmentation3.29125103
10MP0005409_darkened_coat_color3.23627434
11MP0002132_abnormal_respiratory_system3.12601678
12MP0005083_abnormal_biliary_tract2.87545771
13MP0002160_abnormal_reproductive_system2.51738232
14MP0002638_abnormal_pupillary_reflex2.50943834
15MP0004133_heterotaxia2.37967491
16MP0008789_abnormal_olfactory_epithelium2.28449728
17MP0001984_abnormal_olfaction2.10447760
18MP0002277_abnormal_respiratory_mucosa2.08395874
19MP0005377_hearing/vestibular/ear_phenot2.07150704
20MP0003878_abnormal_ear_physiology2.07150704
21MP0001968_abnormal_touch/_nociception2.02546528
22MP0001502_abnormal_circadian_rhythm1.95381792
23MP0001765_abnormal_ion_homeostasis1.86887799
24MP0004019_abnormal_vitamin_homeostasis1.81431224
25MP0009780_abnormal_chondrocyte_physiolo1.79335192
26MP0001756_abnormal_urination1.72125271
27MP0002735_abnormal_chemical_nociception1.67725016
28MP0005623_abnormal_meninges_morphology1.64475117
29MP0000015_abnormal_ear_pigmentation1.62217593
30MP0000751_myopathy1.57175537
31MP0005499_abnormal_olfactory_system1.47366726
32MP0005394_taste/olfaction_phenotype1.47366726
33MP0004381_abnormal_hair_follicle1.44444606
34MP0002909_abnormal_adrenal_gland1.43992341
35MP0003453_abnormal_keratinocyte_physiol1.43453817
36MP0005410_abnormal_fertilization1.34881779
37MP0000678_abnormal_parathyroid_gland1.31212372
38MP0002736_abnormal_nociception_after1.29583110
39MP0005389_reproductive_system_phenotype1.24094698
40MP0000013_abnormal_adipose_tissue1.18932374
41MP0000383_abnormal_hair_follicle1.14373902
42MP0001346_abnormal_lacrimal_gland1.14189064
43MP0001664_abnormal_digestion1.14079238
44MP0005365_abnormal_bile_salt1.11298904
45MP0001929_abnormal_gametogenesis1.10972802
46MP0005551_abnormal_eye_electrophysiolog1.08255446
47MP0003698_abnormal_male_reproductive1.05445485
48MP0002282_abnormal_trachea_morphology1.03587575
49MP0002249_abnormal_larynx_morphology0.97626319
50MP0003656_abnormal_erythrocyte_physiolo0.96797036
51MP0000566_synostosis0.94470492
52MP0009643_abnormal_urine_homeostasis0.90315902
53MP0001661_extended_life_span0.89247468
54MP0000538_abnormal_urinary_bladder0.89053349
55MP0002168_other_aberrant_phenotype0.87297946
56MP0005636_abnormal_mineral_homeostasis0.85688162
57MP0010030_abnormal_orbit_morphology0.84220907
58MP0001324_abnormal_eye_pigmentation0.83107264
59MP0010386_abnormal_urinary_bladder0.81332379
60MP0010678_abnormal_skin_adnexa0.76784999
61MP0002136_abnormal_kidney_physiology0.74476705
62MP0001970_abnormal_pain_threshold0.73203859
63MP0005395_other_phenotype0.71546503
64MP0005332_abnormal_amino_acid0.70634359
65MP0002928_abnormal_bile_duct0.70363958
66MP0000026_abnormal_inner_ear0.68966290
67MP0005501_abnormal_skin_physiology0.66206012
68MP0002210_abnormal_sex_determination0.66119957
69MP0001919_abnormal_reproductive_system0.65815975
70MP0005076_abnormal_cell_differentiation0.64298164
71MP0005220_abnormal_exocrine_pancreas0.63762942
72MP0003806_abnormal_nucleotide_metabolis0.63728226
73MP0000358_abnormal_cell_content/0.62321495
74MP0005330_cardiomyopathy0.60410943
75MP0005253_abnormal_eye_physiology0.60337131
76MP0002734_abnormal_mechanical_nocicepti0.58933934
77MP0002161_abnormal_fertility/fecundity0.57405740
78MP0005584_abnormal_enzyme/coenzyme_acti0.56216197
79MP0000003_abnormal_adipose_tissue0.55900381
80MP0010771_integument_phenotype0.54188124
81MP0005248_abnormal_Harderian_gland0.52966201
82MP0001905_abnormal_dopamine_level0.52238548
83MP0004130_abnormal_muscle_cell0.51136858
84MP0006036_abnormal_mitochondrial_physio0.50111865
85MP0001145_abnormal_male_reproductive0.49032575
86MP0005084_abnormal_gallbladder_morpholo0.48480041
87MP0003718_maternal_effect0.47974000
88MP0001270_distended_abdomen0.46642749
89MP0000750_abnormal_muscle_regeneration0.46473605
90MP0003303_peritoneal_inflammation0.45921109
91MP0002876_abnormal_thyroid_physiology0.44656403
92MP0003137_abnormal_impulse_conducting0.43918743
93MP0000653_abnormal_sex_gland0.43200116
94MP0000681_abnormal_thyroid_gland0.41654771
95MP0000367_abnormal_coat/_hair0.40535211
96MP0010155_abnormal_intestine_physiology0.40494176
97MP0005085_abnormal_gallbladder_physiolo0.39230963
98MP0000470_abnormal_stomach_morphology0.38782557
99MP0001944_abnormal_pancreas_morphology0.38203112
100MP0000747_muscle_weakness0.38026615

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.84684876
2Abnormal respiratory motile cilium morphology (HP:0005938)9.84684876
3Dynein arm defect of respiratory motile cilia (HP:0012255)9.56329107
4Absent/shortened dynein arms (HP:0200106)9.56329107
5Abnormal respiratory motile cilium physiology (HP:0012261)9.48865070
6Abnormal ciliary motility (HP:0012262)9.27806077
7Rhinitis (HP:0012384)8.59917299
8Chronic bronchitis (HP:0004469)6.56678241
9Nasal polyposis (HP:0100582)6.26092505
10Bronchiectasis (HP:0002110)6.25998654
11Abnormality of the nasal mucosa (HP:0000433)5.16426881
12Male infertility (HP:0003251)4.78319772
13Infertility (HP:0000789)4.54486089
14Recurrent sinusitis (HP:0011108)3.53737732
15Bronchitis (HP:0012387)3.47648850
16Occipital encephalocele (HP:0002085)3.31033081
17Chronic sinusitis (HP:0011109)3.27088087
18Rib fusion (HP:0000902)3.22188499
19Recurrent otitis media (HP:0000403)3.20770157
20Testicular atrophy (HP:0000029)3.14566616
21Popliteal pterygium (HP:0009756)3.12161343
22Atelectasis (HP:0100750)2.98975685
23Pancreatic fibrosis (HP:0100732)2.89614629
24True hermaphroditism (HP:0010459)2.87599973
25Aplasia of the musculature (HP:0100854)2.85715961
26Fetal akinesia sequence (HP:0001989)2.81394911
27Nephronophthisis (HP:0000090)2.79645183
28Dyschromatopsia (HP:0007641)2.77266879
29Chronic hepatic failure (HP:0100626)2.71048553
30Molar tooth sign on MRI (HP:0002419)2.65764164
31Abnormality of midbrain morphology (HP:0002418)2.65764164
32Decreased circulating renin level (HP:0003351)2.54586658
33Attenuation of retinal blood vessels (HP:0007843)2.49020515
34Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.46594647
35Cystic liver disease (HP:0006706)2.46512820
36Hyperactive renin-angiotensin system (HP:0000841)2.44616266
37Poikiloderma (HP:0001029)2.33900881
38Pancreatic cysts (HP:0001737)2.29438978
39Chronic otitis media (HP:0000389)2.28558739
40Vaginal fistula (HP:0004320)2.27317166
41Ulnar bowing (HP:0003031)2.23764725
42Bony spicule pigmentary retinopathy (HP:0007737)2.20990985
43Decreased central vision (HP:0007663)2.18858214
44Facial hemangioma (HP:0000329)2.18348413
45Congenital hepatic fibrosis (HP:0002612)2.18194998
46Annular pancreas (HP:0001734)2.13407910
47Abnormality of the renal medulla (HP:0100957)2.10051918
48Rectal fistula (HP:0100590)2.09999345
49Rectovaginal fistula (HP:0000143)2.09999345
50Tubular atrophy (HP:0000092)2.06276401
51Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.7385312
52Postaxial foot polydactyly (HP:0001830)1.96197685
53Turricephaly (HP:0000262)1.95650627
54Thin bony cortex (HP:0002753)1.93848279
55Congenital stationary night blindness (HP:0007642)1.93292515
56Akinesia (HP:0002304)1.93129042
57Intestinal fistula (HP:0100819)1.92947095
58Male pseudohermaphroditism (HP:0000037)1.91846472
59Anteriorly placed anus (HP:0001545)1.90948332
60Abnormal drinking behavior (HP:0030082)1.89522397
61Polydipsia (HP:0001959)1.89522397
62Anencephaly (HP:0002323)1.80092768
63Tubulointerstitial nephritis (HP:0001970)1.79002867
64Hemorrhage of the eye (HP:0011885)1.73746186
65Facial diplegia (HP:0001349)1.70201200
66Hyperkalemia (HP:0002153)1.69997971
67Coronal craniosynostosis (HP:0004440)1.68733383
68Abnormality of renin-angiotensin system (HP:0000847)1.68480546
69Hyponatremia (HP:0002902)1.66326784
70Bell-shaped thorax (HP:0001591)1.64117600
71Squamous cell carcinoma (HP:0002860)1.63290910
72Aplasia/Hypoplasia involving the musculature (HP:0001460)1.61028796
73Aplasia/Hypoplasia of the tongue (HP:0010295)1.59165402
74Abnormality of the intrinsic pathway (HP:0010989)1.55646189
75Hypoalbuminemia (HP:0003073)1.53090524
76Abnormal albumin level (HP:0012116)1.53090524
77Nephropathy (HP:0000112)1.51219754
78Renal salt wasting (HP:0000127)1.51151237
79Choroideremia (HP:0001139)1.49601335
80Absent speech (HP:0001344)1.49003256
81Chorioretinal atrophy (HP:0000533)1.47658885
82Abnormality of the hepatic vasculature (HP:0006707)1.47258191
83Asplenia (HP:0001746)1.45899490
84Medial flaring of the eyebrow (HP:0010747)1.44060889
85Short thorax (HP:0010306)1.43963207
86Abnormality of the costochondral junction (HP:0000919)1.43741056
87Aplasia/Hypoplasia of the spleen (HP:0010451)1.43510607
88Stage 5 chronic kidney disease (HP:0003774)1.43006592
89Mesangial abnormality (HP:0001966)1.41485093
90Prolonged partial thromboplastin time (HP:0003645)1.38332011
91Abnormality of chloride homeostasis (HP:0011422)1.37884092
92Joint hemorrhage (HP:0005261)1.37832645
93Abnormality of placental membranes (HP:0011409)1.37806306
94Amniotic constriction ring (HP:0009775)1.37806306
95Hand muscle atrophy (HP:0009130)1.36124156
96Recurrent bronchitis (HP:0002837)1.35191143
97Atrioventricular block (HP:0001678)1.34563837
98Hypophosphatemic rickets (HP:0004912)1.34561835
99Lip pit (HP:0100267)1.34493449
100Oculomotor apraxia (HP:0000657)1.33598596

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA23.44635368
2MST43.32211903
3WNK42.85457067
4TLK12.28056441
5MAPK1513.4468369
6GRK61.75143993
7MUSK1.74038259
8PNCK1.44347431
9BLK1.39839409
10MAPKAPK31.37621279
11STK161.31141735
12MST1R1.25420745
13EEF2K1.24371119
14TRIB31.24085913
15CSK1.15022167
16SMG11.09182531
17TTK0.99039273
18MAP3K30.98105214
19NME10.98082530
20MAP3K20.98015792
21NEK60.96917999
22PTK2B0.96304056
23CDK80.95192012
24ADRBK10.92111884
25PDPK10.91564544
26TESK20.88249555
27DYRK1B0.87435546
28ICK0.83547655
29PRKCI0.81230133
30SIK20.80514717
31ACVR1B0.80393865
32TBK10.76724987
33ADRBK20.74485789
34CCNB10.72594030
35STK240.69539771
36PIM20.69535478
37AURKA0.69377539
38STK380.66584189
39WNK10.65800426
40ZAP700.65121058
41MET0.62755036
42LRRK20.60066062
43PRKD20.58326368
44RIPK40.57723226
45ARAF0.57666475
46ZAK0.57583701
47PLK40.56258033
48MAP3K70.55893231
49MARK20.55598432
50MAP2K20.55570230
51RPS6KA20.54060433
52NEK20.54050976
53STK390.51222572
54TESK10.50595525
55CDK60.48590126
56OXSR10.48012137
57CAMKK10.46362436
58PLK10.45506897
59EPHB10.44386554
60PRKD10.42708141
61TRPM70.41714868
62BMPR1B0.39528581
63PRKCQ0.37540688
64MAP2K10.35632167
65PRKD30.35623296
66SGK2230.34880734
67SGK4940.34880734
68RPS6KB20.34529427
69DYRK30.33752828
70PBK0.33135066
71PRKCD0.30891159
72MAPK110.30882093
73SGK10.30445508
74AKT20.30008410
75CDK40.29934816
76ERBB20.29525065
77IRAK20.29468887
78ERN10.28934117
79PAK10.28074864
80MAPK120.26654291
81CHEK20.26073820
82MAP2K30.25572348
83CAMK2G0.25363040
84PINK10.25173517
85MAP2K60.25125631
86STK100.23880864
87ATR0.22590281
88TSSK60.22027690
89BMX0.21726522
90PRKACA0.21135423
91PAK40.20709734
92NEK90.20653506
93MAP2K40.20497217
94ROCK10.20479399
95GRK10.20260344
96CDK120.19902619
97STK110.19782996
98MAPK80.18578333
99HIPK20.17427924
100RPS6KA60.17266591

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006045.66897292
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.99490838
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.96015655
4Phenylalanine metabolism_Homo sapiens_hsa003603.91289128
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.71952973
6Sulfur relay system_Homo sapiens_hsa041223.50425899
7Chemical carcinogenesis_Homo sapiens_hsa052043.40757502
8Histidine metabolism_Homo sapiens_hsa003403.14199481
9Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.03408782
10Tyrosine metabolism_Homo sapiens_hsa003502.81664985
11Sphingolipid metabolism_Homo sapiens_hsa006002.29051313
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.06860311
13Fructose and mannose metabolism_Homo sapiens_hsa000511.98227473
14Glutathione metabolism_Homo sapiens_hsa004801.96560968
15beta-Alanine metabolism_Homo sapiens_hsa004101.94826037
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.92680893
17Huntingtons disease_Homo sapiens_hsa050161.91873310
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.88754911
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.87556012
20Circadian rhythm_Homo sapiens_hsa047101.71341392
21Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.64072681
22Retinol metabolism_Homo sapiens_hsa008301.53918509
23Taste transduction_Homo sapiens_hsa047421.52972979
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.48763309
25Caffeine metabolism_Homo sapiens_hsa002321.48248728
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.46991546
27Hedgehog signaling pathway_Homo sapiens_hsa043401.36265199
28Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.32681927
29Linoleic acid metabolism_Homo sapiens_hsa005911.22679947
30Fatty acid degradation_Homo sapiens_hsa000711.18915090
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14548856
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.10347473
33Carbohydrate digestion and absorption_Homo sapiens_hsa049731.04785930
34Vitamin digestion and absorption_Homo sapiens_hsa049771.03075605
35ABC transporters_Homo sapiens_hsa020101.02521405
36Nicotine addiction_Homo sapiens_hsa050331.02130680
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.95001323
38Fanconi anemia pathway_Homo sapiens_hsa034600.83954474
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83372777
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.81086752
41Cocaine addiction_Homo sapiens_hsa050300.71210884
42Peroxisome_Homo sapiens_hsa041460.69807438
43Glycerophospholipid metabolism_Homo sapiens_hsa005640.69105309
44Calcium signaling pathway_Homo sapiens_hsa040200.64914257
45Pyruvate metabolism_Homo sapiens_hsa006200.61951138
46Tight junction_Homo sapiens_hsa045300.61227910
47Drug metabolism - other enzymes_Homo sapiens_hsa009830.57904625
48Basal cell carcinoma_Homo sapiens_hsa052170.57777551
49N-Glycan biosynthesis_Homo sapiens_hsa005100.55378345
50Ovarian steroidogenesis_Homo sapiens_hsa049130.53992309
51Metabolic pathways_Homo sapiens_hsa011000.52586423
52Lysosome_Homo sapiens_hsa041420.50830043
53Notch signaling pathway_Homo sapiens_hsa043300.49755359
54Hippo signaling pathway_Homo sapiens_hsa043900.48236437
55Phototransduction_Homo sapiens_hsa047440.46461067
56PPAR signaling pathway_Homo sapiens_hsa033200.46305422
57Cyanoamino acid metabolism_Homo sapiens_hsa004600.44768946
58Arachidonic acid metabolism_Homo sapiens_hsa005900.42172486
59Nitrogen metabolism_Homo sapiens_hsa009100.41100007
60Salivary secretion_Homo sapiens_hsa049700.39715323
61Primary bile acid biosynthesis_Homo sapiens_hsa001200.37959117
62Melanogenesis_Homo sapiens_hsa049160.36514995
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36415256
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.33003903
65Arginine biosynthesis_Homo sapiens_hsa002200.30158357
66Endocytosis_Homo sapiens_hsa041440.27795047
67Fatty acid biosynthesis_Homo sapiens_hsa000610.27540222
68Arginine and proline metabolism_Homo sapiens_hsa003300.27449340
69Hepatitis C_Homo sapiens_hsa051600.27082863
70Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.26868254
71cAMP signaling pathway_Homo sapiens_hsa040240.26304828
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.21239975
73Glycerolipid metabolism_Homo sapiens_hsa005610.20564233
74Amphetamine addiction_Homo sapiens_hsa050310.20040365
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.19821111
76Nucleotide excision repair_Homo sapiens_hsa034200.19438383
77Insulin resistance_Homo sapiens_hsa049310.18367891
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.18361497
79mTOR signaling pathway_Homo sapiens_hsa041500.18196462
80Inositol phosphate metabolism_Homo sapiens_hsa005620.17760083
81Olfactory transduction_Homo sapiens_hsa047400.17295683
82Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.17224691
83Gap junction_Homo sapiens_hsa045400.16037453
84Basal transcription factors_Homo sapiens_hsa030220.15014396
85Axon guidance_Homo sapiens_hsa043600.12827568
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.10400284
87Steroid biosynthesis_Homo sapiens_hsa001000.09882274
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.09764725
89alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.08891251
90Bile secretion_Homo sapiens_hsa049760.08821506
91Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.08474457
92Choline metabolism in cancer_Homo sapiens_hsa052310.08108056
93Purine metabolism_Homo sapiens_hsa002300.07769474
94Mineral absorption_Homo sapiens_hsa049780.07257475
95Alcoholism_Homo sapiens_hsa050340.07144946
96Base excision repair_Homo sapiens_hsa034100.05446915
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.04789240
98Starch and sucrose metabolism_Homo sapiens_hsa005000.04225336
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.03910401
100Tryptophan metabolism_Homo sapiens_hsa003800.03054330

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