C16ORF70

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.49915874
2L-phenylalanine catabolic process (GO:0006559)5.49915874
3negative regulation of fibrinolysis (GO:0051918)5.20365337
4cholesterol efflux (GO:0033344)5.03839728
5L-phenylalanine metabolic process (GO:0006558)4.99121955
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.99121955
7regulation of fibrinolysis (GO:0051917)4.95968374
8aromatic amino acid family catabolic process (GO:0009074)4.43355719
9plasma lipoprotein particle assembly (GO:0034377)4.43188549
10very-low-density lipoprotein particle assembly (GO:0034379)4.36352453
11peptidyl-glutamic acid carboxylation (GO:0017187)4.33189020
12protein carboxylation (GO:0018214)4.33189020
13intestinal cholesterol absorption (GO:0030299)4.32028995
14regulation of protein activation cascade (GO:2000257)4.17358517
15piRNA metabolic process (GO:0034587)4.13023650
16low-density lipoprotein particle remodeling (GO:0034374)4.03353696
17positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.99925161
18regulation of complement activation (GO:0030449)3.98611885
19protein-lipid complex assembly (GO:0065005)3.96708787
20plasma lipoprotein particle remodeling (GO:0034369)3.86324813
21protein-lipid complex remodeling (GO:0034368)3.86324813
22macromolecular complex remodeling (GO:0034367)3.86324813
23high-density lipoprotein particle remodeling (GO:0034375)3.81575171
24complement activation, alternative pathway (GO:0006957)3.70751737
25regulation of cholesterol esterification (GO:0010872)3.64031973
26plasma lipoprotein particle organization (GO:0071827)3.61410324
27phospholipid efflux (GO:0033700)3.60570654
28reverse cholesterol transport (GO:0043691)3.59665191
29plasma lipoprotein particle clearance (GO:0034381)3.50871896
30glycerophospholipid catabolic process (GO:0046475)3.50432601
31indole-containing compound catabolic process (GO:0042436)3.48635582
32indolalkylamine catabolic process (GO:0046218)3.48635582
33tryptophan catabolic process (GO:0006569)3.48635582
34kynurenine metabolic process (GO:0070189)3.44151604
35C4-dicarboxylate transport (GO:0015740)3.44043624
36negative regulation of protein activation cascade (GO:2000258)3.42017048
37negative regulation of sterol transport (GO:0032372)3.41417066
38negative regulation of cholesterol transport (GO:0032375)3.41417066
39protein-lipid complex subunit organization (GO:0071825)3.41013983
40triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.40625788
41diacylglycerol metabolic process (GO:0046339)3.37653683
42DNA methylation involved in gamete generation (GO:0043046)3.32160850
43tryptophan metabolic process (GO:0006568)3.30507746
44aromatic amino acid family metabolic process (GO:0009072)3.30448927
45sodium-independent organic anion transport (GO:0043252)3.25366971
46blood coagulation, intrinsic pathway (GO:0007597)3.24512588
47protein-cofactor linkage (GO:0018065)3.24021363
48phosphate ion transmembrane transport (GO:0035435)3.23602035
49bile acid biosynthetic process (GO:0006699)3.23497814
50basic amino acid transport (GO:0015802)3.22481377
51adaptation of signaling pathway (GO:0023058)3.19914828
52exogenous drug catabolic process (GO:0042738)3.18527027
53indolalkylamine metabolic process (GO:0006586)3.17198636
54pyrimidine-containing compound transmembrane transport (GO:0072531)3.16104155
55cholesterol transport (GO:0030301)3.13522745
56sterol transport (GO:0015918)3.13522745
57triglyceride homeostasis (GO:0070328)3.10406861
58acylglycerol homeostasis (GO:0055090)3.10406861
59cellular ketone body metabolic process (GO:0046950)3.09930079
60heme transport (GO:0015886)3.09910076
61negative regulation of digestive system process (GO:0060457)3.06273438
62imidazole-containing compound metabolic process (GO:0052803)3.02755129
63transepithelial transport (GO:0070633)3.02540587
64cellular biogenic amine catabolic process (GO:0042402)3.01759559
65amine catabolic process (GO:0009310)3.01759559
66tyrosine metabolic process (GO:0006570)3.00878960
67folic acid transport (GO:0015884)2.98025261
68serine family amino acid catabolic process (GO:0009071)2.96710298
69S-adenosylmethionine metabolic process (GO:0046500)2.95466422
70fibrinolysis (GO:0042730)2.95022647
71peptidyl-glutamic acid modification (GO:0018200)2.93578614
72phosphate ion transport (GO:0006817)2.92414595
73acute-phase response (GO:0006953)2.91286222
74glutamate metabolic process (GO:0006536)2.89504882
75drug catabolic process (GO:0042737)2.87347497
76positive regulation of lipoprotein lipase activity (GO:0051006)2.85804275
77positive regulation of triglyceride lipase activity (GO:0061365)2.85804275
78alpha-amino acid catabolic process (GO:1901606)2.84407594
79galactose catabolic process (GO:0019388)2.83973723
80regulation of plasminogen activation (GO:0010755)2.83579449
81regulation of apoptotic cell clearance (GO:2000425)2.81709983
82negative regulation of complement activation (GO:0045916)2.80672184
83oligosaccharide catabolic process (GO:0009313)2.78943178
84bile acid metabolic process (GO:0008206)2.76939955
85galactose metabolic process (GO:0006012)2.72701807
86vitamin transmembrane transport (GO:0035461)2.72146880
87fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.69621052
88lipoprotein metabolic process (GO:0042157)2.69557882
89oxidative demethylation (GO:0070989)2.68584998
90cholesterol homeostasis (GO:0042632)2.68125973
91sterol homeostasis (GO:0055092)2.65827307
92epoxygenase P450 pathway (GO:0019373)2.64941983
93intestinal absorption (GO:0050892)2.63955989
94ketone body metabolic process (GO:1902224)2.63225569
95detection of light stimulus involved in sensory perception (GO:0050962)2.61708616
96detection of light stimulus involved in visual perception (GO:0050908)2.61708616
97cellular amino acid catabolic process (GO:0009063)2.61256549
98negative regulation of lipase activity (GO:0060192)2.60242751
99regulation of humoral immune response (GO:0002920)2.58662612
100positive regulation of blood coagulation (GO:0030194)2.55619929

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.76541984
2* ZNF274_21170338_ChIP-Seq_K562_Hela4.12900383
3CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.78299704
4CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.64446752
5EGR1_23403033_ChIP-Seq_LIVER_Mouse3.30498301
6VDR_22108803_ChIP-Seq_LS180_Human2.99710059
7RXR_22158963_ChIP-Seq_LIVER_Mouse2.85189573
8LXR_22158963_ChIP-Seq_LIVER_Mouse2.58677097
9IGF1R_20145208_ChIP-Seq_DFB_Human2.57959878
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.57030299
11PPARA_22158963_ChIP-Seq_LIVER_Mouse2.48914062
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.42428205
13NOTCH1_21737748_ChIP-Seq_TLL_Human2.25536326
14GBX2_23144817_ChIP-Seq_PC3_Human2.16847589
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.07706466
16* HNF4A_19822575_ChIP-Seq_HepG2_Human2.07253202
17* FOXA2_19822575_ChIP-Seq_HepG2_Human2.03329150
18CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.84478557
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.77867634
20OCT4_20526341_ChIP-Seq_ESCs_Human1.70677603
21IRF8_22096565_ChIP-ChIP_GC-B_Human1.64870862
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.63022238
23NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.52996231
24RAC3_21632823_ChIP-Seq_H3396_Human1.48659556
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.46204589
26ER_23166858_ChIP-Seq_MCF-7_Human1.42357144
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41672812
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.41565405
29HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.41095051
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.39576455
31AR_20517297_ChIP-Seq_VCAP_Human1.37153348
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.35596064
33MYC_19829295_ChIP-Seq_ESCs_Human1.35519486
34NANOG_19829295_ChIP-Seq_ESCs_Human1.35367609
35SOX2_19829295_ChIP-Seq_ESCs_Human1.35367609
36EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.34332163
37CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.34259764
38GABP_17652178_ChIP-ChIP_JURKAT_Human1.34244156
39ERA_21632823_ChIP-Seq_H3396_Human1.33406906
40FOXH1_21741376_ChIP-Seq_EPCs_Human1.32861997
41IRF8_21731497_ChIP-ChIP_J774_Mouse1.32412493
42GATA3_21878914_ChIP-Seq_MCF-7_Human1.28002651
43HOXB7_26014856_ChIP-Seq_BT474_Human1.27147140
44TP53_22573176_ChIP-Seq_HFKS_Human1.27064839
45FOXA1_21572438_ChIP-Seq_LNCaP_Human1.26229770
46LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.24330559
47NCOR_22424771_ChIP-Seq_293T_Human1.23456099
48POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23257091
49PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.21492585
50SALL1_21062744_ChIP-ChIP_HESCs_Human1.21350220
51ETV2_25802403_ChIP-Seq_MESCs_Mouse1.19720734
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.19653519
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19635493
54NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.18463632
55FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17793944
56FOXA1_25329375_ChIP-Seq_VCAP_Human1.17793944
57GATA3_26560356_Chip-Seq_TH2_Human1.17263849
58AR_21572438_ChIP-Seq_LNCaP_Human1.16773498
59STAT3_23295773_ChIP-Seq_U87_Human1.11451291
60SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11393549
61GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11175453
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10734318
63YY1_21170310_ChIP-Seq_MESCs_Mouse1.09821360
64* TAF2_19829295_ChIP-Seq_ESCs_Human1.06809744
65RXRA_24833708_ChIP-Seq_LIVER_Mouse1.05400404
66P300_19829295_ChIP-Seq_ESCs_Human1.05248373
67TCF4_23295773_ChIP-Seq_U87_Human1.04340314
68FOXH1_21741376_ChIP-Seq_ESCs_Human1.04167541
69KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03864972
70EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01178473
71GATA4_25053715_ChIP-Seq_YYC3_Human1.00476202
72NANOG_20526341_ChIP-Seq_ESCs_Human0.99410396
73PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.96388101
74CTBP1_25329375_ChIP-Seq_LNCAP_Human0.96185752
75AR_25329375_ChIP-Seq_VCAP_Human0.95987246
76REST_18959480_ChIP-ChIP_MESCs_Mouse0.95714233
77TAF15_26573619_Chip-Seq_HEK293_Human0.94969137
78CDX2_22108803_ChIP-Seq_LS180_Human0.94557119
79SRF_21415370_ChIP-Seq_HL-1_Mouse0.92575801
80IRF8_27001747_Chip-Seq_BMDM_Mouse0.90470756
81TCF4_22108803_ChIP-Seq_LS180_Human0.89660596
82KAP1_22055183_ChIP-Seq_ESCs_Mouse0.88807087
83EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.87380691
84* SMAD4_21741376_ChIP-Seq_EPCs_Human0.87226386
85* GABP_19822575_ChIP-Seq_HepG2_Human0.86743619
86* GATA3_26560356_Chip-Seq_TH1_Human0.86496009
87PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86441293
88CEBPB_22108803_ChIP-Seq_LS180_Human0.85710510
89VDR_24787735_ChIP-Seq_THP-1_Human0.85489016
90BCAT_22108803_ChIP-Seq_LS180_Human0.84941441
91P53_21459846_ChIP-Seq_SAOS-2_Human0.83414485
92HTT_18923047_ChIP-ChIP_STHdh_Human0.83299087
93SUZ12_27294783_Chip-Seq_NPCs_Mouse0.82866631
94TP53_16413492_ChIP-PET_HCT116_Human0.82861773
95TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.82800307
96PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.82758424
97BCOR_27268052_Chip-Seq_Bcells_Human0.82725891
98Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.80992628
99AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.80924514
100CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.80830248

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.58606947
2MP0003195_calcinosis5.38534767
3MP0005365_abnormal_bile_salt4.03803709
4MP0005360_urolithiasis3.92708577
5MP0008875_abnormal_xenobiotic_pharmacok3.34017429
6MP0003122_maternal_imprinting3.14773122
7MP0005085_abnormal_gallbladder_physiolo3.01602866
8MP0003172_abnormal_lysosome_physiology2.77340410
9MP0010329_abnormal_lipoprotein_level2.57746349
10MP0009840_abnormal_foam_cell2.43781054
11MP0005058_abnormal_lysosome_morphology2.38359892
12MP0001986_abnormal_taste_sensitivity2.18604952
13MP0003252_abnormal_bile_duct2.10934547
14MP0001764_abnormal_homeostasis2.02678226
15MP0008877_abnormal_DNA_methylation2.01766987
16MP0003646_muscle_fatigue1.89937929
17MP0005332_abnormal_amino_acid1.87710496
18MP0005167_abnormal_blood-brain_barrier1.82802914
19MP0008260_abnormal_autophagy1.67229860
20MP0001666_abnormal_nutrient_absorption1.66830448
21MP0000372_irregular_coat_pigmentation1.63530982
22MP0002132_abnormal_respiratory_system1.55158877
23MP0005551_abnormal_eye_electrophysiolog1.49519700
24MP0003011_delayed_dark_adaptation1.44715330
25MP0009046_muscle_twitch1.43050777
26MP0005084_abnormal_gallbladder_morpholo1.42521929
27MP0002118_abnormal_lipid_homeostasis1.41623813
28MP0003191_abnormal_cellular_cholesterol1.40385106
29MP0006082_CNS_inflammation1.34800647
30MP0003878_abnormal_ear_physiology1.34540457
31MP0005377_hearing/vestibular/ear_phenot1.34540457
32MP0003879_abnormal_hair_cell1.33139210
33MP0002138_abnormal_hepatobiliary_system1.28603043
34MP0000609_abnormal_liver_physiology1.16915775
35MP0001501_abnormal_sleep_pattern1.15968444
36MP0003950_abnormal_plasma_membrane1.13503578
37MP0003718_maternal_effect1.08379206
38MP0000604_amyloidosis1.07372804
39MP0005410_abnormal_fertilization1.06509227
40MP0002876_abnormal_thyroid_physiology1.06436699
41MP0010386_abnormal_urinary_bladder1.06416151
42MP0003121_genomic_imprinting1.03215359
43MP0002148_abnormal_hypersensitivity_rea1.02023259
44MP0002653_abnormal_ependyma_morphology0.99778071
45MP0005464_abnormal_platelet_physiology0.99659213
46MP0003303_peritoneal_inflammation0.97901133
47MP0003633_abnormal_nervous_system0.97513569
48MP0005636_abnormal_mineral_homeostasis0.97368827
49MP0004142_abnormal_muscle_tone0.96994343
50MP0003136_yellow_coat_color0.96766095
51MP0005646_abnormal_pituitary_gland0.96661664
52MP0008469_abnormal_protein_level0.96524732
53MP0009764_decreased_sensitivity_to0.94746064
54MP0001324_abnormal_eye_pigmentation0.93839442
55MP0003806_abnormal_nucleotide_metabolis0.93168770
56MP0003183_abnormal_peptide_metabolism0.92405454
57MP0004043_abnormal_pH_regulation0.88881617
58MP0003436_decreased_susceptibility_to0.87784657
59MP0006035_abnormal_mitochondrial_morpho0.86572668
60MP0002837_dystrophic_cardiac_calcinosis0.86327929
61MP0009785_altered_susceptibility_to0.86317477
62MP0001984_abnormal_olfaction0.84202060
63MP0002419_abnormal_innate_immunity0.83917956
64MP0005451_abnormal_body_composition0.83602615
65MP0009745_abnormal_behavioral_response0.81154945
66MP0000371_diluted_coat_color0.81060958
67MP0002064_seizures0.79965293
68MP0003787_abnormal_imprinting0.79938305
69MP0004019_abnormal_vitamin_homeostasis0.79745297
70MP0001502_abnormal_circadian_rhythm0.79289971
71MP0002229_neurodegeneration0.79231433
72MP0003656_abnormal_erythrocyte_physiolo0.78181706
73MP0002102_abnormal_ear_morphology0.76368228
74MP0005408_hypopigmentation0.76184510
75MP0005448_abnormal_energy_balance0.74661357
76MP0009780_abnormal_chondrocyte_physiolo0.74647588
77MP0005584_abnormal_enzyme/coenzyme_acti0.74407396
78MP0004742_abnormal_vestibular_system0.73342897
79MP0000598_abnormal_liver_morphology0.72814845
80MP0001968_abnormal_touch/_nociception0.72655124
81MP0001661_extended_life_span0.72287330
82MP0009642_abnormal_blood_homeostasis0.72213903
83MP0005319_abnormal_enzyme/_coenzyme0.71399189
84MP0003868_abnormal_feces_composition0.70778720
85MP0002078_abnormal_glucose_homeostasis0.70247066
86MP0002971_abnormal_brown_adipose0.69390679
87MP0001486_abnormal_startle_reflex0.67803272
88MP0002272_abnormal_nervous_system0.67479027
89MP0003698_abnormal_male_reproductive0.67083407
90MP0005253_abnormal_eye_physiology0.66973305
91MP0001929_abnormal_gametogenesis0.66504054
92MP0003631_nervous_system_phenotype0.66117415
93MP0005376_homeostasis/metabolism_phenot0.66045976
94MP0000920_abnormal_myelination0.66031084
95MP0005395_other_phenotype0.64586925
96MP0000427_abnormal_hair_cycle0.63439681
97MP0002572_abnormal_emotion/affect_behav0.62005953
98MP0002557_abnormal_social/conspecific_i0.61467482
99MP0001915_intracranial_hemorrhage0.60775126
100MP0004924_abnormal_behavior0.60455652

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.55029562
2Prolonged partial thromboplastin time (HP:0003645)5.48768966
3Abnormality of aromatic amino acid family metabolism (HP:0004338)4.70297159
4Hypobetalipoproteinemia (HP:0003563)4.01887639
5Joint hemorrhage (HP:0005261)3.86710995
6Vacuolated lymphocytes (HP:0001922)3.70956347
7Complement deficiency (HP:0004431)3.46462964
8Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.30269282
9Glomerulonephritis (HP:0000099)2.99630584
10Systemic lupus erythematosus (HP:0002725)2.99592433
11Abnormality of glycolipid metabolism (HP:0010969)2.89533952
12Abnormality of liposaccharide metabolism (HP:0010968)2.89533952
13Abnormality of glycosphingolipid metabolism (HP:0004343)2.89533952
14Increased cerebral lipofuscin (HP:0011813)2.82229602
15Increased neuronal autofluorescent lipopigment (HP:0002074)2.79154798
16Xanthomatosis (HP:0000991)2.77101224
17Epidermoid cyst (HP:0200040)2.76711401
18Abnormality of the common coagulation pathway (HP:0010990)2.75718214
19Acanthocytosis (HP:0001927)2.74402255
20Abnormality of the pubic bones (HP:0003172)2.71619586
21Spontaneous abortion (HP:0005268)2.66962610
22Abnormality of mucopolysaccharide metabolism (HP:0011020)2.63067894
23Abnormality of polysaccharide metabolism (HP:0011012)2.63067894
24Abnormality of glycosaminoglycan metabolism (HP:0004371)2.63067894
25Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.60641670
26Pendular nystagmus (HP:0012043)2.57004957
27Retinal atrophy (HP:0001105)2.52801881
28Mutism (HP:0002300)2.50095122
29Abnormality of monocarboxylic acid metabolism (HP:0010996)2.50042952
30Abnormality of the wing of the ilium (HP:0011867)2.49394988
31Conjugated hyperbilirubinemia (HP:0002908)2.47499482
32Disproportionate short-trunk short stature (HP:0003521)2.43533834
33Hyperalaninemia (HP:0003348)2.38997346
34Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.38997346
35Abnormality of alanine metabolism (HP:0010916)2.38997346
36Mucopolysacchariduria (HP:0008155)2.38158913
37Urinary glycosaminoglycan excretion (HP:0003541)2.38158913
38Intrahepatic cholestasis (HP:0001406)2.36819921
39Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.33617602
40Hypothermia (HP:0002045)2.33238317
41Fibular aplasia (HP:0002990)2.32440911
42Ketosis (HP:0001946)2.25841745
43Metaphyseal irregularity (HP:0003025)2.22518760
44Azoospermia (HP:0000027)2.19694365
45Barrel-shaped chest (HP:0001552)2.18469133
46Retrobulbar optic neuritis (HP:0100654)2.11713456
47Optic neuritis (HP:0100653)2.11713456
48Oligodactyly (hands) (HP:0001180)2.11247909
49Purpura (HP:0000979)2.09976096
50Hypolipoproteinemia (HP:0010981)2.08938940
51Hypoplastic iliac wings (HP:0002866)2.08327563
52Abnormality of the labia minora (HP:0012880)2.05055143
53Generalized aminoaciduria (HP:0002909)2.04783982
54Abnormality of complement system (HP:0005339)2.03834144
55Humeroradial synostosis (HP:0003041)2.02104376
56Synostosis involving the elbow (HP:0003938)2.02104376
57Ketoacidosis (HP:0001993)2.01330880
58Stomatitis (HP:0010280)2.00445882
59Hypoglycemic coma (HP:0001325)2.00349217
60Gingival bleeding (HP:0000225)2.00243487
61Disinhibition (HP:0000734)1.99640577
62Chronic hepatic failure (HP:0100626)1.98692442
63Abolished electroretinogram (ERG) (HP:0000550)1.95993409
64Bile duct proliferation (HP:0001408)1.95393836
65Abnormal biliary tract physiology (HP:0012439)1.95393836
66Pancreatic islet-cell hyperplasia (HP:0004510)1.94195837
67Hyperglycinemia (HP:0002154)1.93400276
68Lissencephaly (HP:0001339)1.92244033
69Agitation (HP:0000713)1.86743378
70Hemorrhage of the eye (HP:0011885)1.86226603
71Hypercholesterolemia (HP:0003124)1.85458864
72Type II lissencephaly (HP:0007260)1.83797717
73Dysostosis multiplex (HP:0000943)1.82791571
74Fat malabsorption (HP:0002630)1.81950487
75Skin nodule (HP:0200036)1.81496857
76Prolonged neonatal jaundice (HP:0006579)1.80742902
77Episodic fever (HP:0001954)1.80620784
78Abnormal protein glycosylation (HP:0012346)1.80271473
79Abnormal glycosylation (HP:0012345)1.80271473
80Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.80271473
81Abnormal protein N-linked glycosylation (HP:0012347)1.80271473
82Mesangial abnormality (HP:0001966)1.80108631
83Type I transferrin isoform profile (HP:0003642)1.79296665
84Loss of speech (HP:0002371)1.76735413
85Hypoplasia of the odontoid process (HP:0003311)1.75014501
86Orchitis (HP:0100796)1.73454530
87Febrile seizures (HP:0002373)1.73438910
88Abnormality of transition element cation homeostasis (HP:0011030)1.72967984
89Decreased electroretinogram (ERG) amplitude (HP:0000654)1.72434134
90Enlarged kidneys (HP:0000105)1.71968855
91Beaking of vertebral bodies (HP:0004568)1.71613442
92Abnormality of dental color (HP:0011073)1.70839205
93Recurrent gram-negative bacterial infections (HP:0005420)1.68814739
94Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.67945046
95Medial flaring of the eyebrow (HP:0010747)1.67678566
96Abnormality of the pancreatic islet cells (HP:0006476)1.65536464
97Abnormality of endocrine pancreas physiology (HP:0012093)1.65536464
98Gangrene (HP:0100758)1.64544387
99CNS demyelination (HP:0007305)1.64102630
100Spastic tetraplegia (HP:0002510)1.63743356

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.33857668
2PDK23.27342553
3WNK42.67732613
4WNK32.44999120
5TAOK32.18081533
6ADRBK22.09761101
7TRIM282.05508080
8MAP4K21.99055068
9MAP2K61.90162785
10SIK21.88686373
11FGFR41.81195919
12PINK11.79957568
13ACVR1B1.77394994
14AKT31.75830214
15EIF2AK31.72224410
16NUAK11.72138193
17CASK1.68969104
18FGFR31.64561686
19INSRR1.59274947
20TNK21.57896782
21SIK31.54597040
22CAMK1D1.51906945
23ZAK1.47399245
24PAK31.46715311
25OXSR11.42748336
26DAPK21.41733645
27PRKCG1.41703078
28MAPK131.41408003
29FGR1.40044423
30GRK11.39580086
31FER1.37382060
32EPHA31.35075706
33PDPK11.34195321
34MATK1.25240215
35PRKCE1.24312989
36PRKCZ1.23498630
37IKBKB1.17451176
38NTRK31.16359570
39MAP3K51.12624784
40BCKDK1.11574466
41STK391.10257906
42MAP3K41.08106070
43CAMKK21.07466180
44PRKAA21.07185918
45PDK11.03277255
46PIK3CA0.97543725
47BRD40.95827661
48MAP3K110.95462509
49PKN10.93066934
50PRKCI0.92972001
51CAMK1G0.91619716
52TYRO30.88082970
53MAPKAPK30.84879409
54TXK0.83591847
55EPHA40.83097453
56MAP2K40.82019505
57PRKAA10.79293594
58MARK30.77081459
59BMPR1B0.75045375
60ERBB20.70615480
61CDK120.70521062
62IRAK10.69839252
63TAOK10.67709156
64PRKCQ0.65417543
65MARK10.65161857
66STK380.63179717
67TBK10.63125738
68STK38L0.59685234
69TGFBR20.58294181
70CHUK0.58249632
71IRAK30.55784905
72PRKD30.55389540
73MAPK110.55327312
74BCR0.53807748
75PRKD20.50088956
76SYK0.47996662
77PRKACG0.46837958
78CSF1R0.46680649
79CAMK40.45995193
80MAP3K60.45072609
81MAP4K10.43935466
82SGK10.43659484
83MAP2K30.43628363
84BLK0.42948276
85SGK20.41257637
86CSNK1A10.40255390
87CDC42BPA0.40228788
88IGF1R0.38904157
89LATS10.38506264
90PHKG10.38071841
91PHKG20.38071841
92PRKG10.37149926
93CSNK1A1L0.36541676
94BMPR20.35305093
95TEC0.33748471
96RET0.33473746
97SGK2230.33254504
98SGK4940.33254504
99FGFR10.32592290
100PRKACA0.32054849

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.15519096
2Complement and coagulation cascades_Homo sapiens_hsa046103.78870423
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.57922088
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.40021689
5Butanoate metabolism_Homo sapiens_hsa006502.39925335
6Fatty acid degradation_Homo sapiens_hsa000712.10390847
7Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.08993639
8Glycosaminoglycan degradation_Homo sapiens_hsa005312.02273438
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.98075907
10Caffeine metabolism_Homo sapiens_hsa002321.96478770
11Steroid biosynthesis_Homo sapiens_hsa001001.86693151
12Other glycan degradation_Homo sapiens_hsa005111.86321200
13Tryptophan metabolism_Homo sapiens_hsa003801.86157449
14Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.85841898
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.78456392
16Lysosome_Homo sapiens_hsa041421.74985118
17Staphylococcus aureus infection_Homo sapiens_hsa051501.69457160
18Pentose and glucuronate interconversions_Homo sapiens_hsa000401.68976188
19Fatty acid metabolism_Homo sapiens_hsa012121.67768412
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.63941820
21Arginine biosynthesis_Homo sapiens_hsa002201.63518811
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.63287619
23Retinol metabolism_Homo sapiens_hsa008301.61678414
24ABC transporters_Homo sapiens_hsa020101.57252564
25Histidine metabolism_Homo sapiens_hsa003401.55975734
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55858536
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.54676392
28Sphingolipid metabolism_Homo sapiens_hsa006001.54351982
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.49398897
30Chemical carcinogenesis_Homo sapiens_hsa052041.48188046
31Steroid hormone biosynthesis_Homo sapiens_hsa001401.47145921
32Peroxisome_Homo sapiens_hsa041461.40823058
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.39247098
34Vitamin digestion and absorption_Homo sapiens_hsa049771.37524102
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.36378380
36PPAR signaling pathway_Homo sapiens_hsa033201.34807943
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.33674524
38Fatty acid biosynthesis_Homo sapiens_hsa000611.32773096
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.29254294
40Collecting duct acid secretion_Homo sapiens_hsa049661.24095372
41Fat digestion and absorption_Homo sapiens_hsa049751.24049278
42Phenylalanine metabolism_Homo sapiens_hsa003601.22933883
43Cyanoamino acid metabolism_Homo sapiens_hsa004601.22208656
44Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.21002672
45Linoleic acid metabolism_Homo sapiens_hsa005911.15634317
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.12751919
47Tyrosine metabolism_Homo sapiens_hsa003501.10518951
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.08880330
49Selenocompound metabolism_Homo sapiens_hsa004501.08859234
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.08841254
51Propanoate metabolism_Homo sapiens_hsa006401.06274464
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.03039113
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01912371
54Regulation of autophagy_Homo sapiens_hsa041401.01758125
55beta-Alanine metabolism_Homo sapiens_hsa004101.01107901
56Fatty acid elongation_Homo sapiens_hsa000620.98736033
57Starch and sucrose metabolism_Homo sapiens_hsa005000.94952805
58Arginine and proline metabolism_Homo sapiens_hsa003300.94866277
59Galactose metabolism_Homo sapiens_hsa000520.86716126
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.86193463
61Mineral absorption_Homo sapiens_hsa049780.84052137
62Basal transcription factors_Homo sapiens_hsa030220.82044930
63Lysine degradation_Homo sapiens_hsa003100.77219633
64Glycerolipid metabolism_Homo sapiens_hsa005610.76193560
65Sulfur metabolism_Homo sapiens_hsa009200.75748977
66Bile secretion_Homo sapiens_hsa049760.74093669
67Ether lipid metabolism_Homo sapiens_hsa005650.73045733
68Vitamin B6 metabolism_Homo sapiens_hsa007500.72786238
69Cysteine and methionine metabolism_Homo sapiens_hsa002700.72648540
70Nicotine addiction_Homo sapiens_hsa050330.64207640
71Nitrogen metabolism_Homo sapiens_hsa009100.62548636
722-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.57031863
73Metabolic pathways_Homo sapiens_hsa011000.52823383
74Pertussis_Homo sapiens_hsa051330.51076020
75Arachidonic acid metabolism_Homo sapiens_hsa005900.49264809
76Synaptic vesicle cycle_Homo sapiens_hsa047210.46907817
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43490871
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42657470
79Ovarian steroidogenesis_Homo sapiens_hsa049130.42194425
80Vibrio cholerae infection_Homo sapiens_hsa051100.42065387
81NOD-like receptor signaling pathway_Homo sapiens_hsa046210.41147079
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.40435067
83Rheumatoid arthritis_Homo sapiens_hsa053230.40269300
84Phototransduction_Homo sapiens_hsa047440.39380652
85Insulin resistance_Homo sapiens_hsa049310.37092549
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.35691512
87Glucagon signaling pathway_Homo sapiens_hsa049220.32215164
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28446048
89mTOR signaling pathway_Homo sapiens_hsa041500.25212266
90One carbon pool by folate_Homo sapiens_hsa006700.25091339
91Osteoclast differentiation_Homo sapiens_hsa043800.22997857
92Taste transduction_Homo sapiens_hsa047420.22993863
93N-Glycan biosynthesis_Homo sapiens_hsa005100.22763167
94Toll-like receptor signaling pathway_Homo sapiens_hsa046200.22242620
95Tuberculosis_Homo sapiens_hsa051520.22049309
96Phagosome_Homo sapiens_hsa041450.19515100
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.18080080
98RNA degradation_Homo sapiens_hsa030180.17152773
99AMPK signaling pathway_Homo sapiens_hsa041520.16511950
100Pyruvate metabolism_Homo sapiens_hsa006200.16110168

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