C16ORF52

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.94593051
2glutamate secretion (GO:0014047)4.87144234
3synaptic vesicle docking involved in exocytosis (GO:0016081)4.79415649
4cellular potassium ion homeostasis (GO:0030007)4.76772118
5synaptic vesicle maturation (GO:0016188)4.74286375
6regulation of short-term neuronal synaptic plasticity (GO:0048172)4.59156741
7positive regulation of dendritic spine morphogenesis (GO:0061003)4.51542719
8sodium ion export (GO:0071436)4.42929876
9short-term memory (GO:0007614)4.04376741
10ionotropic glutamate receptor signaling pathway (GO:0035235)3.92015955
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.90519669
12neuron recognition (GO:0008038)3.85018785
13synaptic vesicle exocytosis (GO:0016079)3.79579472
14neuronal action potential propagation (GO:0019227)3.72313948
15protein localization to synapse (GO:0035418)3.67874842
16synaptic transmission, glutamatergic (GO:0035249)3.64041854
17motile cilium assembly (GO:0044458)3.60645681
18exploration behavior (GO:0035640)3.60054269
19locomotory exploration behavior (GO:0035641)3.59993368
20cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.58976500
21positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.56895062
22gamma-aminobutyric acid signaling pathway (GO:0007214)3.52530385
23glutamate receptor signaling pathway (GO:0007215)3.47106187
24regulation of synaptic vesicle exocytosis (GO:2000300)3.41406559
25neurotransmitter secretion (GO:0007269)3.36797011
26neuron-neuron synaptic transmission (GO:0007270)3.34725454
27axonal fasciculation (GO:0007413)3.33350784
28positive regulation of synapse maturation (GO:0090129)3.33248040
29cellular sodium ion homeostasis (GO:0006883)3.33224668
30layer formation in cerebral cortex (GO:0021819)3.29948676
31regulation of dendritic spine morphogenesis (GO:0061001)3.28680434
32gamma-aminobutyric acid transport (GO:0015812)3.26536534
33negative regulation of dendrite morphogenesis (GO:0050774)3.25889910
34positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.24298170
35regulation of synaptic vesicle transport (GO:1902803)3.22243414
36potassium ion homeostasis (GO:0055075)3.18745625
37cerebellar granule cell differentiation (GO:0021707)3.16863998
38cell communication by electrical coupling (GO:0010644)3.11237583
39positive regulation of dendritic spine development (GO:0060999)3.10968914
40negative regulation of synaptic transmission, GABAergic (GO:0032229)3.09239660
41neurotransmitter-gated ion channel clustering (GO:0072578)3.04009945
42postsynaptic membrane organization (GO:0001941)3.03792248
43membrane depolarization during action potential (GO:0086010)3.02862516
44axon ensheathment in central nervous system (GO:0032291)3.00826613
45central nervous system myelination (GO:0022010)3.00826613
46positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.97756884
47regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.97530844
48regulation of excitatory postsynaptic membrane potential (GO:0060079)2.96800677
49regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.95770166
50regulation of voltage-gated calcium channel activity (GO:1901385)2.94928185
51regulation of long-term neuronal synaptic plasticity (GO:0048169)2.92793937
52regulation of neuronal synaptic plasticity (GO:0048168)2.90145262
53vocalization behavior (GO:0071625)2.89545438
54detection of calcium ion (GO:0005513)2.88666535
55potassium ion import (GO:0010107)2.88638300
56neuromuscular synaptic transmission (GO:0007274)2.86205520
57regulation of synapse maturation (GO:0090128)2.84126380
58regulation of dendritic spine development (GO:0060998)2.82825311
59behavioral defense response (GO:0002209)2.81688537
60behavioral fear response (GO:0001662)2.81688537
61regulation of neurotransmitter secretion (GO:0046928)2.80087510
62regulation of synapse assembly (GO:0051963)2.78488281
63regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.76622317
64regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.75542978
65regulation of postsynaptic membrane potential (GO:0060078)2.74706529
66membrane depolarization (GO:0051899)2.74328896
67regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.72033981
68positive regulation of synapse assembly (GO:0051965)2.71495457
69dendrite morphogenesis (GO:0048813)2.68468566
70dendrite development (GO:0016358)2.66368012
71adult walking behavior (GO:0007628)2.64096535
72positive regulation of sodium ion transmembrane transport (GO:1902307)2.63067341
73behavioral response to cocaine (GO:0048148)2.61665270
74cerebellar Purkinje cell differentiation (GO:0021702)2.60645736
75neuronal ion channel clustering (GO:0045161)2.59835063
76regulation of cAMP-dependent protein kinase activity (GO:2000479)2.57919693
77regulation of neurotransmitter transport (GO:0051588)2.57584996
78regulation of glutamate receptor signaling pathway (GO:1900449)2.57308007
79neurotransmitter transport (GO:0006836)2.57026490
80fear response (GO:0042596)2.56877907
81negative regulation of sodium ion transport (GO:0010766)2.55104515
82cell communication involved in cardiac conduction (GO:0086065)2.54622622
83presynaptic membrane organization (GO:0097090)2.54121123
84chemosensory behavior (GO:0007635)2.53868865
85negative regulation of fatty acid transport (GO:2000192)2.53864653
86presynaptic membrane assembly (GO:0097105)2.53718104
87regulation of dendrite morphogenesis (GO:0048814)2.51413312
88neuron cell-cell adhesion (GO:0007158)2.51307214
89positive regulation of dendrite morphogenesis (GO:0050775)2.50866624
90positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.49434379
91chondrocyte proliferation (GO:0035988)2.49362407
92transmission of nerve impulse (GO:0019226)2.48604612
93regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.46350036
94regulation of vesicle fusion (GO:0031338)2.46120461
95regulation of synaptic plasticity (GO:0048167)2.45628550
96axon extension (GO:0048675)2.45527394
97cell migration in hindbrain (GO:0021535)2.45168415
98positive regulation of membrane potential (GO:0045838)2.43400693
99regulation of synapse organization (GO:0050807)2.42770571
100limb bud formation (GO:0060174)2.42274265

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.44448188
2EZH2_22144423_ChIP-Seq_EOC_Human2.79125091
3CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.68188520
4AR_21572438_ChIP-Seq_LNCaP_Human2.51189149
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.43895944
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.43890570
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.23629279
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.17859557
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.16965767
10SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.14178090
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.06874847
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.05885753
13TAF15_26573619_Chip-Seq_HEK293_Human2.04282574
14CDX2_19796622_ChIP-Seq_MESCs_Mouse2.01646818
15RNF2_18974828_ChIP-Seq_MESCs_Mouse1.97562643
16EZH2_18974828_ChIP-Seq_MESCs_Mouse1.97562643
17VDR_22108803_ChIP-Seq_LS180_Human1.96212646
18FUS_26573619_Chip-Seq_HEK293_Human1.94647612
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.94231495
20EED_16625203_ChIP-ChIP_MESCs_Mouse1.90595288
21REST_21632747_ChIP-Seq_MESCs_Mouse1.88727352
22POU3F2_20337985_ChIP-ChIP_501MEL_Human1.88491591
23PIAS1_25552417_ChIP-Seq_VCAP_Human1.86829037
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.83626687
25EZH2_27304074_Chip-Seq_ESCs_Mouse1.81395446
26SMAD4_21799915_ChIP-Seq_A2780_Human1.81380176
27SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.80327177
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.79186883
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.78532693
30MTF2_20144788_ChIP-Seq_MESCs_Mouse1.78224705
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71322308
32SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.69822706
33PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.69182801
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68839052
35RNF2_27304074_Chip-Seq_ESCs_Mouse1.67091811
36JARID2_20075857_ChIP-Seq_MESCs_Mouse1.66042888
37SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.63632466
38P300_19829295_ChIP-Seq_ESCs_Human1.62611372
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62418197
40OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59714897
41RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57233835
42ZNF217_24962896_ChIP-Seq_MCF-7_Human1.53022195
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51969296
44EP300_21415370_ChIP-Seq_HL-1_Mouse1.51027283
45TP53_16413492_ChIP-PET_HCT116_Human1.50566007
46NR3C1_23031785_ChIP-Seq_PC12_Mouse1.49996928
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48855733
48* STAT3_23295773_ChIP-Seq_U87_Human1.48385671
49RNF2_27304074_Chip-Seq_NSC_Mouse1.47889243
50RARB_27405468_Chip-Seq_BRAIN_Mouse1.47738913
51CTNNB1_20460455_ChIP-Seq_HCT116_Human1.47539235
52SALL1_21062744_ChIP-ChIP_HESCs_Human1.45175821
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.44571336
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.44234490
55TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.40381707
56HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.39940620
57CBX2_27304074_Chip-Seq_ESCs_Mouse1.39807715
58EZH2_27294783_Chip-Seq_ESCs_Mouse1.37877612
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37259996
60REST_18959480_ChIP-ChIP_MESCs_Mouse1.36902587
61EWS_26573619_Chip-Seq_HEK293_Human1.35627230
62* TCF4_23295773_ChIP-Seq_U87_Human1.35390698
63RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.33604250
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.33294942
65NRF2_20460467_ChIP-Seq_MEFs_Mouse1.29096597
66NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.29096597
67SUZ12_27294783_Chip-Seq_ESCs_Mouse1.27990759
68UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27928094
69WT1_19549856_ChIP-ChIP_CCG9911_Human1.27661327
70TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26513828
71POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26513828
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25523553
73CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25109783
74FLI1_27457419_Chip-Seq_LIVER_Mouse1.25072214
75TP53_18474530_ChIP-ChIP_U2OS_Human1.24800915
76SOX2_21211035_ChIP-Seq_LN229_Gbm1.23359620
77ARNT_22903824_ChIP-Seq_MCF-7_Human1.23121312
78CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.22067213
79AHR_22903824_ChIP-Seq_MCF-7_Human1.21630095
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.21372569
81BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20899113
82PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.18826612
83KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.17523766
84ER_23166858_ChIP-Seq_MCF-7_Human1.16983972
85AR_25329375_ChIP-Seq_VCAP_Human1.14770763
86TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.14631472
87TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13255009
88YAP1_20516196_ChIP-Seq_MESCs_Mouse1.13238797
89IGF1R_20145208_ChIP-Seq_DFB_Human1.12233546
90NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11731504
91WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11262971
92KDM2B_26808549_Chip-Seq_REH_Human1.11114384
93MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11105078
94ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.11100128
95DROSHA_22980978_ChIP-Seq_HELA_Human1.11085380
96* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09569646
97AR_19668381_ChIP-Seq_PC3_Human1.08150141
98RUNX2_22187159_ChIP-Seq_PCA_Human1.05736940
99SOX9_26525672_Chip-Seq_HEART_Mouse1.05245870
100KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04242330

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.54089499
2MP0003880_abnormal_central_pattern3.79275028
3MP0003123_paternal_imprinting3.68005161
4MP0009046_muscle_twitch3.11714819
5MP0003635_abnormal_synaptic_transmissio3.08506927
6MP0004270_analgesia2.89507412
7MP0005423_abnormal_somatic_nervous2.68245572
8MP0002064_seizures2.61301823
9MP0002272_abnormal_nervous_system2.59257899
10MP0002063_abnormal_learning/memory/cond2.42256430
11MP0009745_abnormal_behavioral_response2.39469571
12MP0000569_abnormal_digit_pigmentation2.37075930
13MP0001486_abnormal_startle_reflex2.11934024
14MP0001501_abnormal_sleep_pattern2.05091863
15MP0002572_abnormal_emotion/affect_behav1.97356479
16MP0009780_abnormal_chondrocyte_physiolo1.96639383
17MP0002734_abnormal_mechanical_nocicepti1.93185315
18MP0000778_abnormal_nervous_system1.79053716
19MP0002735_abnormal_chemical_nociception1.78805523
20MP0008569_lethality_at_weaning1.76974301
21MP0003121_genomic_imprinting1.74330667
22MP0003122_maternal_imprinting1.70338853
23MP0001968_abnormal_touch/_nociception1.66093925
24MP0002184_abnormal_innervation1.64187765
25MP0002067_abnormal_sensory_capabilities1.62163265
26MP0001440_abnormal_grooming_behavior1.62122716
27MP0001299_abnormal_eye_distance/1.48860789
28MP0000955_abnormal_spinal_cord1.43757469
29MP0001970_abnormal_pain_threshold1.40596079
30MP0000534_abnormal_ureter_morphology1.37259389
31MP0002733_abnormal_thermal_nociception1.36478061
32MP0004811_abnormal_neuron_physiology1.35645934
33MP0001984_abnormal_olfaction1.31846756
34MP0008877_abnormal_DNA_methylation1.29628831
35MP0010386_abnormal_urinary_bladder1.28346591
36MP0002557_abnormal_social/conspecific_i1.28272398
37MP0002882_abnormal_neuron_morphology1.25623684
38MP0003890_abnormal_embryonic-extraembry1.23564043
39MP0001348_abnormal_lacrimal_gland1.20505046
40MP0003633_abnormal_nervous_system1.19704612
41MP0002066_abnormal_motor_capabilities/c1.16710042
42MP0002152_abnormal_brain_morphology1.15298752
43MP0004142_abnormal_muscle_tone1.14912564
44MP0001188_hyperpigmentation1.14575173
45MP0004885_abnormal_endolymph1.11757926
46MP0004924_abnormal_behavior1.10452131
47MP0005386_behavior/neurological_phenoty1.10452131
48MP0002736_abnormal_nociception_after1.09259621
49MP0002160_abnormal_reproductive_system1.08721052
50MP0003631_nervous_system_phenotype1.05124488
51MP0003787_abnormal_imprinting1.04422084
52MP0003942_abnormal_urinary_system1.03319233
53MP0004742_abnormal_vestibular_system1.03063189
54MP0005646_abnormal_pituitary_gland1.02851219
55MP0000537_abnormal_urethra_morphology1.01803020
56MP0000749_muscle_degeneration1.00501150
57MP0003315_abnormal_perineum_morphology0.97639897
58MP0003879_abnormal_hair_cell0.97035711
59MP0001502_abnormal_circadian_rhythm0.96202462
60MP0005367_renal/urinary_system_phenotyp0.95664609
61MP0000516_abnormal_urinary_system0.95664609
62MP0009250_abnormal_appendicular_skeleto0.95539687
63MP0005551_abnormal_eye_electrophysiolog0.95520060
64MP0004484_altered_response_of0.94413985
65MP0003861_abnormal_nervous_system0.91487520
66MP0005409_darkened_coat_color0.90997051
67MP0004215_abnormal_myocardial_fiber0.90933403
68MP0002638_abnormal_pupillary_reflex0.89294431
69MP0003385_abnormal_body_wall0.87548445
70MP0006276_abnormal_autonomic_nervous0.86343711
71MP0003632_abnormal_nervous_system0.82324558
72MP0003755_abnormal_palate_morphology0.81160840
73MP0000920_abnormal_myelination0.80128292
74MP0005503_abnormal_tendon_morphology0.79389317
75MP0005174_abnormal_tail_pigmentation0.76582980
76MP0002752_abnormal_somatic_nervous0.76566167
77MP0009384_cardiac_valve_regurgitation0.76472439
78MP0002108_abnormal_muscle_morphology0.75159026
79MP0000427_abnormal_hair_cycle0.74511909
80MP0008057_abnormal_DNA_replication0.70898670
81MP0004134_abnormal_chest_morphology0.70820275
82MP0008872_abnormal_physiological_respon0.70659531
83MP0003937_abnormal_limbs/digits/tail_de0.70246855
84MP0000639_abnormal_adrenal_gland0.70064514
85MP0004084_abnormal_cardiac_muscle0.69830854
86MP0004145_abnormal_muscle_electrophysio0.69461081
87MP0009379_abnormal_foot_pigmentation0.68795748
88MP0001485_abnormal_pinna_reflex0.67955810
89MP0003936_abnormal_reproductive_system0.67945846
90MP0005187_abnormal_penis_morphology0.66195693
91MP0000631_abnormal_neuroendocrine_gland0.65664581
92MP0003634_abnormal_glial_cell0.65427651
93MP0002822_catalepsy0.65299896
94MP0003329_amyloid_beta_deposits0.64928178
95MP0005670_abnormal_white_adipose0.64452278
96MP0002177_abnormal_outer_ear0.64282047
97MP0003941_abnormal_skin_development0.64233985
98MP0005620_abnormal_muscle_contractility0.63490996
99MP0004272_abnormal_basement_membrane0.62590303
100MP0001529_abnormal_vocalization0.62495699

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.21829384
2Febrile seizures (HP:0002373)5.80475093
3Focal seizures (HP:0007359)5.18242494
4Atonic seizures (HP:0010819)5.04722955
5Absence seizures (HP:0002121)4.12802320
6Myokymia (HP:0002411)4.11722949
7Epileptic encephalopathy (HP:0200134)4.04059848
8Dialeptic seizures (HP:0011146)4.00988584
9Generalized tonic-clonic seizures (HP:0002069)3.57944403
10Action tremor (HP:0002345)3.53086539
11Broad-based gait (HP:0002136)2.94455751
12Abnormality of the corticospinal tract (HP:0002492)2.94433906
13Progressive cerebellar ataxia (HP:0002073)2.88657928
14Urinary bladder sphincter dysfunction (HP:0002839)2.82026981
15Impaired vibration sensation in the lower limbs (HP:0002166)2.74930644
16Urinary urgency (HP:0000012)2.69377241
17Gaze-evoked nystagmus (HP:0000640)2.57798006
18Degeneration of the lateral corticospinal tracts (HP:0002314)2.56269206
19Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.56269206
20Scanning speech (HP:0002168)2.50870021
21Drooling (HP:0002307)2.36157203
22Visual hallucinations (HP:0002367)2.35793576
23Absent speech (HP:0001344)2.30167350
24Spastic gait (HP:0002064)2.27438945
25Bundle branch block (HP:0011710)2.22376446
26Ankle clonus (HP:0011448)2.22347483
27Status epilepticus (HP:0002133)2.20427847
28Protruding tongue (HP:0010808)2.13823691
29Hyperventilation (HP:0002883)2.13466328
30Arterial tortuosity (HP:0005116)2.11518485
31Megalencephaly (HP:0001355)2.08469855
32Dysmetria (HP:0001310)2.08293874
33Akinesia (HP:0002304)2.07808700
34Excessive salivation (HP:0003781)2.06982370
35Aplasia involving bones of the extremities (HP:0009825)2.06622370
36Aplasia involving bones of the upper limbs (HP:0009823)2.06622370
37Aplasia of the phalanges of the hand (HP:0009802)2.06622370
38Postural instability (HP:0002172)2.05201612
39Genetic anticipation (HP:0003743)2.04890789
40Limb dystonia (HP:0002451)2.04541903
41Vascular tortuosity (HP:0004948)2.00287454
42Termporal pattern (HP:0011008)1.97006736
43Insidious onset (HP:0003587)1.97006736
44Epileptiform EEG discharges (HP:0011182)1.94069067
45Truncal ataxia (HP:0002078)1.87224959
46Failure to thrive in infancy (HP:0001531)1.86910795
47Exotropia (HP:0000577)1.85832977
48Supranuclear gaze palsy (HP:0000605)1.82017042
49Submucous cleft hard palate (HP:0000176)1.81165594
50Dysmetric saccades (HP:0000641)1.80965900
51Amblyopia (HP:0000646)1.79440888
52Impaired vibratory sensation (HP:0002495)1.78658496
53Lower limb muscle weakness (HP:0007340)1.76024872
54Torticollis (HP:0000473)1.73594268
55Limited hip movement (HP:0008800)1.69838944
56Microglossia (HP:0000171)1.69170815
57Abnormality of binocular vision (HP:0011514)1.68038887
58Diplopia (HP:0000651)1.68038887
59Genital tract atresia (HP:0001827)1.67022677
60EEG with generalized epileptiform discharges (HP:0011198)1.66927992
61Thickened helices (HP:0000391)1.66513644
62Molar tooth sign on MRI (HP:0002419)1.65646447
63Abnormality of midbrain morphology (HP:0002418)1.65646447
64Widely spaced teeth (HP:0000687)1.63676826
65Morphological abnormality of the pyramidal tract (HP:0002062)1.60823858
66Gait imbalance (HP:0002141)1.60797005
67Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.60348962
68Abnormal eating behavior (HP:0100738)1.60320426
69Fair hair (HP:0002286)1.57121738
70Impaired smooth pursuit (HP:0007772)1.56933337
71Anxiety (HP:0000739)1.56560229
72Obstructive sleep apnea (HP:0002870)1.56553388
73Vaginal atresia (HP:0000148)1.55736174
74Chronic hepatic failure (HP:0100626)1.55496241
75Incomplete penetrance (HP:0003829)1.53596065
76Abnormality of the lower motor neuron (HP:0002366)1.50826275
77Depression (HP:0000716)1.50397938
78Epiphyseal dysplasia (HP:0002656)1.49018428
79Alacrima (HP:0000522)1.48480514
80Overgrowth (HP:0001548)1.47689915
81Papilledema (HP:0001085)1.47532730
82Abnormality of ocular smooth pursuit (HP:0000617)1.47340926
83Decreased lacrimation (HP:0000633)1.47144541
84Intellectual disability, moderate (HP:0002342)1.47118523
85Sensory axonal neuropathy (HP:0003390)1.46435048
86Coronal craniosynostosis (HP:0004440)1.46316589
87Poor coordination (HP:0002370)1.46108646
88Flat cornea (HP:0007720)1.45490426
89Blue irides (HP:0000635)1.45406383
90Clonus (HP:0002169)1.45233763
91Hypsarrhythmia (HP:0002521)1.44734955
92Abnormality of the nasal septum (HP:0000419)1.44651947
93Cerebral hypomyelination (HP:0006808)1.44230827
94Striae distensae (HP:0001065)1.43656498
95Deeply set eye (HP:0000490)1.43212572
96Generalized myoclonic seizures (HP:0002123)1.42834434
97Papillary thyroid carcinoma (HP:0002895)1.42543353
98Arnold-Chiari malformation (HP:0002308)1.41677642
99Horizontal nystagmus (HP:0000666)1.40957445
100Pulmonic stenosis (HP:0001642)1.39220739

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.26059633
2MARK13.57672689
3EPHA43.55397071
4TAF13.43925965
5LATS23.09162284
6PINK12.86046933
7NTRK32.85271151
8MAP3K92.66060395
9NTRK22.45065635
10NTRK12.38732681
11AKT32.25742730
12LATS12.03034486
13MAP3K41.78627788
14TNIK1.68900755
15MINK11.57021965
16SIK21.54738500
17MKNK21.51128500
18DYRK1A1.41966790
19PHKG21.36075870
20PHKG11.36075870
21PAK61.35552383
22PRKCG1.31257283
23KSR11.30033104
24PAK31.28869830
25SGK21.24952269
26MAP2K71.22874317
27PLK21.18742580
28MAP3K21.18572400
29DAPK21.18234325
30SGK4941.14429985
31SGK2231.14429985
32CAMKK11.12414421
33FGFR31.07775901
34GRK51.06255155
35CDK51.03534147
36CAMK11.01759255
37UHMK11.01064591
38STK38L0.99657110
39TYRO30.98655866
40STK380.97678169
41CAMK1G0.96565315
42SGK10.89949013
43KSR20.85401886
44LMTK20.84353414
45CAMK2A0.83580966
46BMPR1B0.81791363
47MAPK130.80276493
48WNK10.80118929
49PNCK0.79522917
50STK110.79378678
51CAMK1D0.77669495
52SGK30.75862603
53ERBB40.75303907
54MARK20.75242912
55PDGFRB0.74879293
56OBSCN0.73820240
57CAMK2B0.72957235
58PRKCE0.72525622
59BCR0.71922848
60STK390.71599376
61MAP2K40.69982140
62FGFR10.68602340
63CAMK40.67507234
64DMPK0.65588702
65DYRK30.65382044
66ERBB30.65235734
67CAMKK20.64470877
68PDGFRA0.64323927
69MAPK120.61458876
70NUAK10.61291235
71FRK0.60310877
72TGFBR20.58339813
73CDK180.57361267
74MAPKAPK50.55943145
75CDK140.55664473
76PTK20.55387659
77CDK150.55345313
78CSNK1A1L0.54797883
79PRKD30.53537528
80RPS6KA30.52358322
81MELK0.51904403
82CDK11A0.51098040
83CDK30.50152792
84DYRK1B0.49306432
85OXSR10.48630973
86PIK3CA0.48374649
87CSNK1G20.48104819
88MAPK100.46497024
89CSNK1E0.46429478
90PRKCH0.45386138
91RPS6KB10.40811120
92MKNK10.40704160
93PRKCZ0.40239341
94TGFBR10.39904280
95NME10.39760913
96FGFR20.39369066
97CDK90.38586819
98MARK30.38041060
99DAPK10.35122023
100PTK2B0.35064281

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.82691438
2Long-term potentiation_Homo sapiens_hsa047202.51744035
3Glutamatergic synapse_Homo sapiens_hsa047242.40279900
4Amphetamine addiction_Homo sapiens_hsa050312.15302693
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.15299640
6GABAergic synapse_Homo sapiens_hsa047272.14750657
7Morphine addiction_Homo sapiens_hsa050322.08186887
8Circadian entrainment_Homo sapiens_hsa047132.07655741
9Cocaine addiction_Homo sapiens_hsa050302.05257981
10Synaptic vesicle cycle_Homo sapiens_hsa047211.98729456
11Insulin secretion_Homo sapiens_hsa049111.89602416
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.88824506
13Dopaminergic synapse_Homo sapiens_hsa047281.83413353
14Salivary secretion_Homo sapiens_hsa049701.75183071
15Gastric acid secretion_Homo sapiens_hsa049711.66258522
16Cholinergic synapse_Homo sapiens_hsa047251.60532380
17Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.59199162
18Circadian rhythm_Homo sapiens_hsa047101.53659269
19Long-term depression_Homo sapiens_hsa047301.52360988
20Oxytocin signaling pathway_Homo sapiens_hsa049211.49241661
21Hedgehog signaling pathway_Homo sapiens_hsa043401.46627751
22Taste transduction_Homo sapiens_hsa047421.45371009
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.38785761
24Olfactory transduction_Homo sapiens_hsa047401.36378995
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.33878757
26Axon guidance_Homo sapiens_hsa043601.32998355
27Renin secretion_Homo sapiens_hsa049241.32522378
28cAMP signaling pathway_Homo sapiens_hsa040241.26004054
29Melanogenesis_Homo sapiens_hsa049161.25820792
30cGMP-PKG signaling pathway_Homo sapiens_hsa040221.24581160
31Glioma_Homo sapiens_hsa052141.22116513
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.20216278
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.19653383
34Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.19503811
35ErbB signaling pathway_Homo sapiens_hsa040121.18934165
36Fatty acid biosynthesis_Homo sapiens_hsa000611.17640045
37Calcium signaling pathway_Homo sapiens_hsa040201.17191934
38Wnt signaling pathway_Homo sapiens_hsa043101.15242296
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13754626
40Estrogen signaling pathway_Homo sapiens_hsa049151.12579662
41Gap junction_Homo sapiens_hsa045401.10487573
42Dilated cardiomyopathy_Homo sapiens_hsa054141.10256576
43ECM-receptor interaction_Homo sapiens_hsa045121.08825076
44Hippo signaling pathway_Homo sapiens_hsa043901.05765931
45Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.05679605
46Dorso-ventral axis formation_Homo sapiens_hsa043201.05437876
47Basal cell carcinoma_Homo sapiens_hsa052171.05220561
48Serotonergic synapse_Homo sapiens_hsa047261.02188100
49Glucagon signaling pathway_Homo sapiens_hsa049221.02085369
50Thyroid hormone synthesis_Homo sapiens_hsa049181.00460656
51Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98379484
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98005331
53GnRH signaling pathway_Homo sapiens_hsa049120.97115538
54Vascular smooth muscle contraction_Homo sapiens_hsa042700.92663238
55Cardiac muscle contraction_Homo sapiens_hsa042600.92626970
56Adherens junction_Homo sapiens_hsa045200.88003052
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84958385
58MAPK signaling pathway_Homo sapiens_hsa040100.84253388
59TGF-beta signaling pathway_Homo sapiens_hsa043500.78683426
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77242826
61Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77219041
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.75100330
63Oocyte meiosis_Homo sapiens_hsa041140.75061219
64Ras signaling pathway_Homo sapiens_hsa040140.75052659
65Endometrial cancer_Homo sapiens_hsa052130.74772462
66Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73973983
67Focal adhesion_Homo sapiens_hsa045100.72707050
68Pancreatic secretion_Homo sapiens_hsa049720.71445700
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.68518772
70Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66427355
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65674284
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65231691
73Inositol phosphate metabolism_Homo sapiens_hsa005620.63695235
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63142664
75Nitrogen metabolism_Homo sapiens_hsa009100.62503206
76Melanoma_Homo sapiens_hsa052180.61929351
77Proteoglycans in cancer_Homo sapiens_hsa052050.61841763
78Rap1 signaling pathway_Homo sapiens_hsa040150.61094428
79Type II diabetes mellitus_Homo sapiens_hsa049300.60177627
80mTOR signaling pathway_Homo sapiens_hsa041500.59948272
81FoxO signaling pathway_Homo sapiens_hsa040680.59824307
82Phototransduction_Homo sapiens_hsa047440.59792177
83Choline metabolism in cancer_Homo sapiens_hsa052310.59225411
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58060519
85AMPK signaling pathway_Homo sapiens_hsa041520.57744287
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52739888
87Renal cell carcinoma_Homo sapiens_hsa052110.49860025
88Prion diseases_Homo sapiens_hsa050200.49412978
89Mineral absorption_Homo sapiens_hsa049780.48730619
90Tight junction_Homo sapiens_hsa045300.48584784
91Bile secretion_Homo sapiens_hsa049760.48398356
92Colorectal cancer_Homo sapiens_hsa052100.47999500
93MicroRNAs in cancer_Homo sapiens_hsa052060.45782054
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45380876
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40712089
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.40637170
97Insulin signaling pathway_Homo sapiens_hsa049100.38257190
98PI3K-Akt signaling pathway_Homo sapiens_hsa041510.37895247
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.36812896
100Prostate cancer_Homo sapiens_hsa052150.35654855

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