C15ORF61

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.16382285
2protein complex biogenesis (GO:0070271)5.57790578
3ATP synthesis coupled proton transport (GO:0015986)5.54950089
4energy coupled proton transport, down electrochemical gradient (GO:0015985)5.54950089
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.52884259
6chaperone-mediated protein transport (GO:0072321)5.44992288
7mitochondrial respiratory chain complex I assembly (GO:0032981)5.32418953
8NADH dehydrogenase complex assembly (GO:0010257)5.32418953
9mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.32418953
10mitochondrial respiratory chain complex assembly (GO:0033108)5.18406025
11respiratory electron transport chain (GO:0022904)5.00642462
12electron transport chain (GO:0022900)4.93935658
13establishment of protein localization to mitochondrial membrane (GO:0090151)4.19836254
14peptidyl-histidine modification (GO:0018202)3.96403344
15DNA deamination (GO:0045006)3.95420284
16cytochrome complex assembly (GO:0017004)3.91915968
17regulation of mitochondrial translation (GO:0070129)3.90456103
18respiratory chain complex IV assembly (GO:0008535)3.89284739
19deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.77316873
20maturation of 5.8S rRNA (GO:0000460)3.73296850
21pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.71896628
22metallo-sulfur cluster assembly (GO:0031163)3.69260781
23iron-sulfur cluster assembly (GO:0016226)3.69260781
24protein neddylation (GO:0045116)3.61165307
25ATP biosynthetic process (GO:0006754)3.60339991
26viral transcription (GO:0019083)3.56350174
27translational termination (GO:0006415)3.54924569
28purine nucleoside triphosphate biosynthetic process (GO:0009145)3.52427506
29purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.50712749
30hydrogen ion transmembrane transport (GO:1902600)3.48764820
31pseudouridine synthesis (GO:0001522)3.40764822
32termination of RNA polymerase III transcription (GO:0006386)3.38847695
33transcription elongation from RNA polymerase III promoter (GO:0006385)3.38847695
34ribosomal small subunit biogenesis (GO:0042274)3.35902407
35protein-cofactor linkage (GO:0018065)3.34608342
36water-soluble vitamin biosynthetic process (GO:0042364)3.33397588
37behavioral response to nicotine (GO:0035095)3.31130302
38protein targeting to mitochondrion (GO:0006626)3.28679093
39proton transport (GO:0015992)3.25102776
40proteasome assembly (GO:0043248)3.21273634
41heme transport (GO:0015886)3.20513646
42GTP biosynthetic process (GO:0006183)3.20226482
43hydrogen transport (GO:0006818)3.18898062
44SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.18044055
45protein K6-linked ubiquitination (GO:0085020)3.13637759
46L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.13272267
47cotranslational protein targeting to membrane (GO:0006613)3.13075423
48protein targeting to ER (GO:0045047)3.11746916
49translational elongation (GO:0006414)3.11497816
50base-excision repair, AP site formation (GO:0006285)3.08855832
51regulation of appetite (GO:0032098)3.08649726
52establishment of protein localization to mitochondrion (GO:0072655)3.06704905
53ribonucleoside triphosphate biosynthetic process (GO:0009201)3.06284057
54exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.06209359
55pyrimidine nucleotide catabolic process (GO:0006244)3.02468992
56protein localization to endoplasmic reticulum (GO:0070972)3.02172508
57nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.01586834
58mitochondrial transport (GO:0006839)2.97485138
59establishment of protein localization to endoplasmic reticulum (GO:0072599)2.96857275
60ribosomal small subunit assembly (GO:0000028)2.96375533
61protein localization to mitochondrion (GO:0070585)2.95656373
62organic cation transport (GO:0015695)2.91539499
63oxidative phosphorylation (GO:0006119)2.90506846
64cellular ketone body metabolic process (GO:0046950)2.89151786
65tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.85746450
66RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.85746450
67ubiquinone biosynthetic process (GO:0006744)2.85214687
68intracellular protein transmembrane import (GO:0044743)2.82256050
69deoxyribonucleotide catabolic process (GO:0009264)2.79801228
70response to pheromone (GO:0019236)2.78778701
71UTP metabolic process (GO:0046051)2.78567579
72nucleoside triphosphate biosynthetic process (GO:0009142)2.77501218
73glycerophospholipid catabolic process (GO:0046475)2.77432912
74regulation of glucokinase activity (GO:0033131)2.77424278
75regulation of hexokinase activity (GO:1903299)2.77424278
76maturation of SSU-rRNA (GO:0030490)2.74932394
77nucleotide transmembrane transport (GO:1901679)2.74298727
78cellular component biogenesis (GO:0044085)2.70679958
79protein K11-linked deubiquitination (GO:0035871)2.70184730
80aerobic respiration (GO:0009060)2.69785865
81translation (GO:0006412)2.69591550
82inner mitochondrial membrane organization (GO:0007007)2.68921324
83UTP biosynthetic process (GO:0006228)2.66216666
84purine nucleotide salvage (GO:0032261)2.65267450
85negative regulation of response to food (GO:0032096)2.64762568
86negative regulation of appetite (GO:0032099)2.64762568
87cellular protein complex disassembly (GO:0043624)2.62908465
88male meiosis I (GO:0007141)2.62764578
89amino acid salvage (GO:0043102)2.60201026
90L-methionine salvage (GO:0071267)2.60201026
91L-methionine biosynthetic process (GO:0071265)2.60201026
92pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.58764289
93piRNA metabolic process (GO:0034587)2.58028304
94translational initiation (GO:0006413)2.57494938
95ketone body metabolic process (GO:1902224)2.56443430
96viral life cycle (GO:0019058)2.55672428
97aggressive behavior (GO:0002118)2.54632420
98mannosylation (GO:0097502)2.54071883
99deoxyribose phosphate catabolic process (GO:0046386)2.53397479
100ubiquinone metabolic process (GO:0006743)2.52277619

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.36328622
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.75730418
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.52700838
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.26675737
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.24287456
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.20642940
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.03634071
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.95900503
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.92223265
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.87045533
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.55006737
12EZH2_22144423_ChIP-Seq_EOC_Human2.52020701
13ZNF274_21170338_ChIP-Seq_K562_Hela2.51105144
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.41617889
15VDR_23849224_ChIP-Seq_CD4+_Human2.36737549
16IGF1R_20145208_ChIP-Seq_DFB_Human2.18876524
17SRF_21415370_ChIP-Seq_HL-1_Mouse2.08831394
18VDR_22108803_ChIP-Seq_LS180_Human2.00427029
19PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.97963541
20FOXP3_21729870_ChIP-Seq_TREG_Human1.87830390
21GBX2_23144817_ChIP-Seq_PC3_Human1.86919755
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.86299384
23THAP11_20581084_ChIP-Seq_MESCs_Mouse1.85826544
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.85171206
25MYC_18555785_ChIP-Seq_MESCs_Mouse1.84084877
26MYC_18940864_ChIP-ChIP_HL60_Human1.76517748
27EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.75915580
28* TP53_22573176_ChIP-Seq_HFKS_Human1.73804952
29DCP1A_22483619_ChIP-Seq_HELA_Human1.70005245
30NOTCH1_21737748_ChIP-Seq_TLL_Human1.69136196
31MYC_18358816_ChIP-ChIP_MESCs_Mouse1.60991249
32CREB1_15753290_ChIP-ChIP_HEK293T_Human1.60533321
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58980996
34GABP_19822575_ChIP-Seq_HepG2_Human1.56192210
35TTF2_22483619_ChIP-Seq_HELA_Human1.49214522
36EWS_26573619_Chip-Seq_HEK293_Human1.47086686
37CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.45651228
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.45267871
39HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.45194701
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.43741171
41CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.42889363
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36063692
43FUS_26573619_Chip-Seq_HEK293_Human1.35967120
44BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.32539215
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.30068059
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.28388943
47ZFP57_27257070_Chip-Seq_ESCs_Mouse1.26291073
48ELK1_19687146_ChIP-ChIP_HELA_Human1.25885386
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23371174
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22888549
51ER_23166858_ChIP-Seq_MCF-7_Human1.19350488
52GATA3_21878914_ChIP-Seq_MCF-7_Human1.18124597
53TAF15_26573619_Chip-Seq_HEK293_Human1.17172955
54GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.16042415
55XRN2_22483619_ChIP-Seq_HELA_Human1.14758336
56POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13868959
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.13466306
58* NCOR_22424771_ChIP-Seq_293T_Human1.12705254
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12653372
60AR_20517297_ChIP-Seq_VCAP_Human1.11861507
61ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.11539780
62FOXA1_25329375_ChIP-Seq_VCAP_Human1.10803732
63FOXA1_27270436_Chip-Seq_PROSTATE_Human1.10803732
64TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07098482
65PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.06959771
66NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.06635957
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06342238
68HTT_18923047_ChIP-ChIP_STHdh_Human1.05914067
69KDM5A_27292631_Chip-Seq_BREAST_Human1.05881718
70ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05525242
71ERA_21632823_ChIP-Seq_H3396_Human1.05353678
72IKZF1_21737484_ChIP-ChIP_HCT116_Human1.04938928
73ERG_20517297_ChIP-Seq_VCAP_Human1.04620970
74SOX2_19829295_ChIP-Seq_ESCs_Human1.03676891
75NANOG_19829295_ChIP-Seq_ESCs_Human1.03676891
76MYC_19829295_ChIP-Seq_ESCs_Human0.99503924
77SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.99337168
78LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.98501620
79EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.98357692
80CBP_20019798_ChIP-Seq_JUKART_Human0.98163507
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98163507
82FOXH1_21741376_ChIP-Seq_EPCs_Human0.98137879
83IRF1_19129219_ChIP-ChIP_H3396_Human0.97104884
84TAF2_19829295_ChIP-Seq_ESCs_Human0.97103122
85REST_21632747_ChIP-Seq_MESCs_Mouse0.97026732
86CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.96596910
87NANOG_20526341_ChIP-Seq_ESCs_Human0.95981792
88PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95575726
89RNF2_27304074_Chip-Seq_NSC_Mouse0.94673633
90P300_19829295_ChIP-Seq_ESCs_Human0.94199706
91E2F1_18555785_ChIP-Seq_MESCs_Mouse0.93424204
92ELF1_17652178_ChIP-ChIP_JURKAT_Human0.93333178
93ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.92633631
94MYC_19030024_ChIP-ChIP_MESCs_Mouse0.92262558
95AUTS2_25519132_ChIP-Seq_293T-REX_Human0.87872739
96HOXB4_20404135_ChIP-ChIP_EML_Mouse0.85874231
97FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.85650914
98BP1_19119308_ChIP-ChIP_Hs578T_Human0.84862471
99RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.84479106
100EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.82182235

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis3.35635529
2MP0004145_abnormal_muscle_electrophysio2.87569371
3MP0003646_muscle_fatigue2.76114150
4MP0003806_abnormal_nucleotide_metabolis2.72894663
5MP0005645_abnormal_hypothalamus_physiol2.53622161
6MP0006036_abnormal_mitochondrial_physio2.49584655
7MP0005646_abnormal_pituitary_gland2.24346474
8MP0009046_muscle_twitch2.13776756
9MP0008877_abnormal_DNA_methylation1.99251400
10MP0002160_abnormal_reproductive_system1.99056804
11MP0001984_abnormal_olfaction1.92593841
12MP0000372_irregular_coat_pigmentation1.91130649
13MP0004142_abnormal_muscle_tone1.87938473
14MP0003195_calcinosis1.86057618
15MP0001905_abnormal_dopamine_level1.84821116
16MP0001968_abnormal_touch/_nociception1.80584453
17MP0002163_abnormal_gland_morphology1.78773947
18MP0003718_maternal_effect1.77864565
19MP0003011_delayed_dark_adaptation1.77643320
20MP0006276_abnormal_autonomic_nervous1.77216871
21MP0009745_abnormal_behavioral_response1.76405168
22MP0001529_abnormal_vocalization1.74911496
23MP0005084_abnormal_gallbladder_morpholo1.74667634
24MP0002876_abnormal_thyroid_physiology1.73891543
25MP0008875_abnormal_xenobiotic_pharmacok1.73385801
26MP0005551_abnormal_eye_electrophysiolog1.72750843
27MP0004147_increased_porphyrin_level1.61424671
28MP0005389_reproductive_system_phenotype1.60287012
29MP0002638_abnormal_pupillary_reflex1.59879572
30MP0006072_abnormal_retinal_apoptosis1.59342893
31MP0002822_catalepsy1.57298395
32MP0002234_abnormal_pharynx_morphology1.54726098
33MP0002736_abnormal_nociception_after1.50801240
34MP0008789_abnormal_olfactory_epithelium1.49587186
35MP0006292_abnormal_olfactory_placode1.48571033
36MP0002272_abnormal_nervous_system1.46658098
37MP0002735_abnormal_chemical_nociception1.42314351
38MP0009379_abnormal_foot_pigmentation1.41138040
39MP0004043_abnormal_pH_regulation1.38628405
40MP0003787_abnormal_imprinting1.38360102
41MP0002064_seizures1.37365696
42MP0008058_abnormal_DNA_repair1.36981290
43MP0002653_abnormal_ependyma_morphology1.36532723
44MP0005332_abnormal_amino_acid1.35838925
45MP0001986_abnormal_taste_sensitivity1.34974342
46MP0003880_abnormal_central_pattern1.34280413
47MP0008995_early_reproductive_senescence1.34151932
48MP0005379_endocrine/exocrine_gland_phen1.31192726
49MP0000631_abnormal_neuroendocrine_gland1.28010332
50MP0001764_abnormal_homeostasis1.27132187
51MP0002102_abnormal_ear_morphology1.26418079
52MP0005253_abnormal_eye_physiology1.25944981
53MP0003186_abnormal_redox_activity1.24162960
54MP0005410_abnormal_fertilization1.24018958
55MP0002938_white_spotting1.20275132
56MP0001919_abnormal_reproductive_system1.17635223
57MP0005266_abnormal_metabolism1.16810285
58MP0003315_abnormal_perineum_morphology1.15509753
59MP0002572_abnormal_emotion/affect_behav1.13730814
60MP0003137_abnormal_impulse_conducting1.08959817
61MP0005394_taste/olfaction_phenotype1.08451110
62MP0005499_abnormal_olfactory_system1.08451110
63MP0005187_abnormal_penis_morphology1.08182505
64MP0008872_abnormal_physiological_respon1.07614361
65MP0006035_abnormal_mitochondrial_morpho1.06168443
66MP0000749_muscle_degeneration1.05658085
67MP0004924_abnormal_behavior1.04087424
68MP0005386_behavior/neurological_phenoty1.04087424
69MP0002733_abnormal_thermal_nociception1.01305508
70MP0002693_abnormal_pancreas_physiology0.98879502
71MP0005075_abnormal_melanosome_morpholog0.98140032
72MP0001970_abnormal_pain_threshold0.97237961
73MP0004215_abnormal_myocardial_fiber0.96420962
74MP0001944_abnormal_pancreas_morphology0.94848634
75MP0001486_abnormal_startle_reflex0.92473877
76MP0009697_abnormal_copulation0.90525638
77MP0002210_abnormal_sex_determination0.89545020
78MP0002734_abnormal_mechanical_nocicepti0.87974502
79MP0001929_abnormal_gametogenesis0.86791760
80MP0001485_abnormal_pinna_reflex0.86009266
81MP0003786_premature_aging0.85604719
82MP0002067_abnormal_sensory_capabilities0.85372670
83MP0002277_abnormal_respiratory_mucosa0.85224765
84MP0003635_abnormal_synaptic_transmissio0.84852140
85MP0004885_abnormal_endolymph0.84197342
86MP0003698_abnormal_male_reproductive0.83999752
87MP0005636_abnormal_mineral_homeostasis0.82486103
88MP0005647_abnormal_sex_gland0.82235570
89MP0004036_abnormal_muscle_relaxation0.78478968
90MP0001440_abnormal_grooming_behavior0.78459728
91MP0004085_abnormal_heartbeat0.78175635
92MP0002557_abnormal_social/conspecific_i0.78121856
93MP0001873_stomach_inflammation0.77725748
94MP0000653_abnormal_sex_gland0.77029251
95MP0010386_abnormal_urinary_bladder0.75457631
96MP0002269_muscular_atrophy0.74409080
97MP0008961_abnormal_basal_metabolism0.74087411
98MP0003283_abnormal_digestive_organ0.73383853
99MP0001145_abnormal_male_reproductive0.72596626
100MP0002106_abnormal_muscle_physiology0.71892835

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.16029468
2Mitochondrial inheritance (HP:0001427)4.86792051
3Abnormal mitochondria in muscle tissue (HP:0008316)4.86453427
4Acute encephalopathy (HP:0006846)4.53198763
5Progressive macrocephaly (HP:0004481)4.47565546
6Increased CSF lactate (HP:0002490)4.33431594
7Hepatic necrosis (HP:0002605)4.28324689
8Hepatocellular necrosis (HP:0001404)4.26452057
9Decreased activity of mitochondrial respiratory chain (HP:0008972)3.86705335
10Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.86705335
113-Methylglutaconic aciduria (HP:0003535)3.59711410
12Lipid accumulation in hepatocytes (HP:0006561)3.54276272
13Increased hepatocellular lipid droplets (HP:0006565)3.48072745
14Increased intramyocellular lipid droplets (HP:0012240)3.42761174
15Renal Fanconi syndrome (HP:0001994)3.27831020
16Lactic acidosis (HP:0003128)3.15575558
17Cerebral edema (HP:0002181)3.14154840
18Increased muscle lipid content (HP:0009058)3.13006960
19Increased serum lactate (HP:0002151)2.86800409
20Respiratory failure (HP:0002878)2.74214044
21Pancreatic cysts (HP:0001737)2.72483492
22Exercise intolerance (HP:0003546)2.67575948
23Abnormal number of erythroid precursors (HP:0012131)2.63149055
24Congenital stationary night blindness (HP:0007642)2.61922083
25Molar tooth sign on MRI (HP:0002419)2.57732490
26Abnormality of midbrain morphology (HP:0002418)2.57732490
27Large for gestational age (HP:0001520)2.57193277
28Pancreatic fibrosis (HP:0100732)2.54742205
29True hermaphroditism (HP:0010459)2.48449845
30Optic disc pallor (HP:0000543)2.46615448
31Ketoacidosis (HP:0001993)2.42701506
32Hyperglycinemia (HP:0002154)2.41103192
33Methylmalonic acidemia (HP:0002912)2.40608578
34Lethargy (HP:0001254)2.38696946
35Muscle fiber inclusion bodies (HP:0100299)2.38666730
36Abnormality of urine glucose concentration (HP:0011016)2.36495933
37Glycosuria (HP:0003076)2.36495933
38Abnormality of dicarboxylic acid metabolism (HP:0010995)2.36393663
39Dicarboxylic aciduria (HP:0003215)2.36393663
40Ketosis (HP:0001946)2.34708109
41Abnormality of alanine metabolism (HP:0010916)2.34692736
42Hyperalaninemia (HP:0003348)2.34692736
43Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.34692736
44Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.34574711
45Hypoplasia of the uterus (HP:0000013)2.29717156
46Exertional dyspnea (HP:0002875)2.27765773
47Type I transferrin isoform profile (HP:0003642)2.27280883
48Abnormality of cells of the erythroid lineage (HP:0012130)2.25788120
49Methylmalonic aciduria (HP:0012120)2.23870964
50Aplasia/hypoplasia of the uterus (HP:0008684)2.22354605
51Generalized aminoaciduria (HP:0002909)2.21387450
52Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.21142001
53Nemaline bodies (HP:0003798)2.17450287
54Renal cortical cysts (HP:0000803)2.16286288
55Hypoglycemic coma (HP:0001325)2.16242310
56Medial flaring of the eyebrow (HP:0010747)2.14704277
57Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.14076713
58CNS demyelination (HP:0007305)2.12292167
59Abnormal protein N-linked glycosylation (HP:0012347)2.10208949
60Abnormal protein glycosylation (HP:0012346)2.10208949
61Abnormal glycosylation (HP:0012345)2.10208949
62Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.10208949
63Abnormal rod and cone electroretinograms (HP:0008323)2.08483147
64Abnormality of renal resorption (HP:0011038)2.08120538
65Absent rod-and cone-mediated responses on ERG (HP:0007688)2.05726809
66Abolished electroretinogram (ERG) (HP:0000550)2.04379158
67Abnormality of the renal cortex (HP:0011035)2.01729602
68Nephronophthisis (HP:0000090)2.01460491
69Macrocytic anemia (HP:0001972)1.99965335
70Leukodystrophy (HP:0002415)1.99790248
71Muscle hypertrophy of the lower extremities (HP:0008968)1.95708728
72Hypothermia (HP:0002045)1.94090081
73Congenital, generalized hypertrichosis (HP:0004540)1.93455177
74Sclerocornea (HP:0000647)1.92864883
75Decreased electroretinogram (ERG) amplitude (HP:0000654)1.91958459
76Abnormal drinking behavior (HP:0030082)1.91883271
77Polydipsia (HP:0001959)1.91883271
78Male pseudohermaphroditism (HP:0000037)1.90248448
79Aplastic anemia (HP:0001915)1.89561701
80Calf muscle hypertrophy (HP:0008981)1.86665682
81Limb dystonia (HP:0002451)1.81959705
82Progressive microcephaly (HP:0000253)1.81796295
83Gait imbalance (HP:0002141)1.81524661
84Unsteady gait (HP:0002317)1.81391871
85Hyperglycinuria (HP:0003108)1.81021911
86Emotional lability (HP:0000712)1.79806043
87Attenuation of retinal blood vessels (HP:0007843)1.77688035
88Congenital primary aphakia (HP:0007707)1.74933702
89Reduced antithrombin III activity (HP:0001976)1.69029550
90Hyperinsulinemic hypoglycemia (HP:0000825)1.68362242
91X-linked dominant inheritance (HP:0001423)1.67045782
92Rectal fistula (HP:0100590)1.66226943
93Rectovaginal fistula (HP:0000143)1.66226943
94Exercise-induced myalgia (HP:0003738)1.65857896
95Absent thumb (HP:0009777)1.65663522
96Abnormality of serine family amino acid metabolism (HP:0010894)1.64822181
97Abnormality of glycine metabolism (HP:0010895)1.64822181
98Testicular atrophy (HP:0000029)1.64763006
99Gliosis (HP:0002171)1.64311666
100Exercise-induced muscle cramps (HP:0003710)1.61761161

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.54660513
2ZAK3.42519648
3PINK13.38436297
4TLK13.13898651
5OBSCN3.10690764
6PHKG12.62452363
7PHKG22.62452363
8WNK32.44748946
9BCKDK2.41105748
10MAP4K22.31420162
11STK162.30270265
12ADRBK22.30258215
13VRK22.27344027
14GRK12.11407801
15CDK192.06941161
16NME21.86154117
17BMPR1B1.63391599
18CSNK1G31.60259475
19VRK11.49007033
20TRIM281.44000328
21NUAK11.36750079
22CSNK1G11.36666427
23KDR1.34624382
24CCNB11.32983246
25CSNK1G21.31510582
26TAOK31.31050260
27LIMK11.23737683
28PIM21.21245637
29NME11.20445582
30DYRK21.20298672
31RPS6KA51.19841568
32CSNK1A1L1.18215655
33DAPK21.16975315
34TESK21.16925107
35NTRK31.15972619
36TNK21.14435188
37MAPK131.11756874
38MAP2K71.10022165
39OXSR11.06035149
40TXK1.04264085
41WNK41.00670817
42MUSK0.93140761
43MAPKAPK30.92154431
44EIF2AK30.90495596
45MAP3K110.89378626
46BUB10.89308881
47INSRR0.87519713
48ABL20.84660884
49MAPKAPK50.82887138
50CASK0.77715041
51PIK3CG0.71205183
52PLK10.67393269
53CAMK2A0.67168710
54CSNK1A10.66979455
55TIE10.65588609
56PRKCG0.65375871
57PKN10.62204609
58ARAF0.61442930
59PRKACA0.60994508
60DAPK10.59891660
61CDC70.58502394
62SCYL20.58492487
63AURKA0.55047225
64GRK50.53942830
65ADRBK10.52638180
66MARK10.51896732
67IKBKB0.51636278
68MAP3K40.51630434
69CSNK2A10.50529683
70PDK20.49657460
71CSNK2A20.48906238
72PLK40.48531438
73ATR0.48522125
74CAMK10.47507679
75DYRK30.47142944
76CHEK20.46963347
77MAP2K60.46125942
78NEK10.45969113
79STK390.45579348
80PRKG10.44832264
81PRKCE0.43575899
82CAMK2D0.42468822
83PIM10.41375013
84PAK30.41271209
85PIK3CA0.40326467
86TEC0.40174218
87KIT0.39706030
88PRKCA0.39392972
89CAMK2G0.36898335
90PRKD20.36205801
91TAF10.36190033
92STK110.35638449
93PRKCI0.34575259
94RPS6KA40.34060498
95ERBB30.33331720
96EIF2AK10.32312326
97CDK30.31877214
98FGFR20.31668821
99TESK10.31169937
100PLK30.29399267

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.67699024
2Parkinsons disease_Homo sapiens_hsa050123.87190123
3Ribosome_Homo sapiens_hsa030103.78754813
4Alzheimers disease_Homo sapiens_hsa050102.65823057
5Huntingtons disease_Homo sapiens_hsa050162.56645587
6RNA polymerase_Homo sapiens_hsa030202.42131916
7Cardiac muscle contraction_Homo sapiens_hsa042602.42011612
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.39085973
9Proteasome_Homo sapiens_hsa030502.33382368
10Protein export_Homo sapiens_hsa030602.23429677
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.10166854
12Sulfur relay system_Homo sapiens_hsa041221.89064067
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.88506591
14Phototransduction_Homo sapiens_hsa047441.83945254
15Folate biosynthesis_Homo sapiens_hsa007901.77363110
16Homologous recombination_Homo sapiens_hsa034401.74004348
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.72753194
18One carbon pool by folate_Homo sapiens_hsa006701.65020368
19Base excision repair_Homo sapiens_hsa034101.63862907
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.59277932
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.55744861
22Butanoate metabolism_Homo sapiens_hsa006501.53812745
23Peroxisome_Homo sapiens_hsa041461.51840854
24Pyrimidine metabolism_Homo sapiens_hsa002401.48560347
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.39423327
26Nitrogen metabolism_Homo sapiens_hsa009101.35588077
27RNA degradation_Homo sapiens_hsa030181.33996126
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.33774987
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32808224
30Linoleic acid metabolism_Homo sapiens_hsa005911.31560592
31Selenocompound metabolism_Homo sapiens_hsa004501.28994163
32Propanoate metabolism_Homo sapiens_hsa006401.26543358
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.25354244
34Purine metabolism_Homo sapiens_hsa002301.21368090
35Nicotine addiction_Homo sapiens_hsa050331.20339483
36Fanconi anemia pathway_Homo sapiens_hsa034601.16788216
37DNA replication_Homo sapiens_hsa030301.12105704
38Basal transcription factors_Homo sapiens_hsa030221.08037158
39Tryptophan metabolism_Homo sapiens_hsa003801.06425644
40SNARE interactions in vesicular transport_Homo sapiens_hsa041301.06374029
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02472143
42Collecting duct acid secretion_Homo sapiens_hsa049661.01597159
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.01290633
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01122414
45Metabolic pathways_Homo sapiens_hsa011000.96549673
46Nucleotide excision repair_Homo sapiens_hsa034200.95327511
47Fatty acid elongation_Homo sapiens_hsa000620.94602444
48Ether lipid metabolism_Homo sapiens_hsa005650.93496019
49Caffeine metabolism_Homo sapiens_hsa002320.89381621
50Olfactory transduction_Homo sapiens_hsa047400.85200404
51Pyruvate metabolism_Homo sapiens_hsa006200.83286003
52Primary bile acid biosynthesis_Homo sapiens_hsa001200.81325972
53Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79529177
54Sulfur metabolism_Homo sapiens_hsa009200.75941771
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.75407452
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.75372580
57Regulation of autophagy_Homo sapiens_hsa041400.75204685
58Mismatch repair_Homo sapiens_hsa034300.73673682
59Steroid hormone biosynthesis_Homo sapiens_hsa001400.73421133
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70424759
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67813925
62Arachidonic acid metabolism_Homo sapiens_hsa005900.66430144
63Fatty acid metabolism_Homo sapiens_hsa012120.64165389
64RNA transport_Homo sapiens_hsa030130.61775225
65Insulin secretion_Homo sapiens_hsa049110.55701058
66GABAergic synapse_Homo sapiens_hsa047270.55328758
67Glutathione metabolism_Homo sapiens_hsa004800.55259322
68Synaptic vesicle cycle_Homo sapiens_hsa047210.55105529
69Spliceosome_Homo sapiens_hsa030400.53896085
70Arginine and proline metabolism_Homo sapiens_hsa003300.53774166
71Fatty acid degradation_Homo sapiens_hsa000710.52979384
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52887653
73ABC transporters_Homo sapiens_hsa020100.52027894
74Morphine addiction_Homo sapiens_hsa050320.51033416
75Primary immunodeficiency_Homo sapiens_hsa053400.50935975
76Circadian rhythm_Homo sapiens_hsa047100.50192507
77Chemical carcinogenesis_Homo sapiens_hsa052040.49451604
78Calcium signaling pathway_Homo sapiens_hsa040200.48330807
79Vitamin digestion and absorption_Homo sapiens_hsa049770.47079138
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46979729
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41467106
82Taste transduction_Homo sapiens_hsa047420.41315275
83Retinol metabolism_Homo sapiens_hsa008300.41306553
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39757573
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37868926
86Serotonergic synapse_Homo sapiens_hsa047260.37823621
87Asthma_Homo sapiens_hsa053100.37059688
882-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.37013056
89beta-Alanine metabolism_Homo sapiens_hsa004100.36741271
90Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.36580770
91Tyrosine metabolism_Homo sapiens_hsa003500.36270808
92Non-homologous end-joining_Homo sapiens_hsa034500.36214765
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32991249
94Type I diabetes mellitus_Homo sapiens_hsa049400.31935148
95Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.31322726
96Salivary secretion_Homo sapiens_hsa049700.31067719
97Intestinal immune network for IgA production_Homo sapiens_hsa046720.30736390
98Mineral absorption_Homo sapiens_hsa049780.29842991
99Circadian entrainment_Homo sapiens_hsa047130.28347375
100Ovarian steroidogenesis_Homo sapiens_hsa049130.27906001

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