C15ORF48

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene was first identified in a study of human esophageal squamous cell carcinoma tissues. Levels of both the message and protein are reduced in carcinoma samples. In adult human tissues, this gene is expressed in the the esophagus, stomach, small intestine, colon and placenta. Alternatively spliced transcript variants that encode the same protein have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of vitamin D biosynthetic process (GO:0060556)5.54857487
2regulation of vitamin metabolic process (GO:0030656)5.11703896
3regulation of mononuclear cell migration (GO:0071675)4.75602175
4negative regulation of interleukin-12 production (GO:0032695)4.45557446
5lipopolysaccharide-mediated signaling pathway (GO:0031663)4.43781800
6regulation of T-helper 1 cell differentiation (GO:0045625)4.35617692
7regulation of cytokine secretion involved in immune response (GO:0002739)4.22511435
8positive regulation of heat generation (GO:0031652)4.20032427
9regulation of podosome assembly (GO:0071801)4.19888889
10response to peptidoglycan (GO:0032494)4.18566482
11regulation of fever generation (GO:0031620)4.17776768
12positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.15238029
13positive regulation of chemokine biosynthetic process (GO:0045080)4.10707358
14regulation of chronic inflammatory response (GO:0002676)4.10525351
15T-helper 1 type immune response (GO:0042088)4.07539053
16eosinophil chemotaxis (GO:0048245)3.91459387
17glycosphingolipid catabolic process (GO:0046479)3.83413449
18immunoglobulin mediated immune response (GO:0016064)3.81220434
19monocyte chemotaxis (GO:0002548)3.74420498
20NIK/NF-kappaB signaling (GO:0038061)3.73854676
21regulation of chemokine biosynthetic process (GO:0045073)3.73294986
22positive regulation of type 2 immune response (GO:0002830)3.69461867
23regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.67788896
24glycolipid catabolic process (GO:0019377)3.54542473
25macrophage activation involved in immune response (GO:0002281)3.51073214
26positive regulation of NF-kappaB import into nucleus (GO:0042346)3.51030770
27neutrophil activation involved in immune response (GO:0002283)3.50080867
28eosinophil migration (GO:0072677)3.45865044
29positive regulation of T-helper cell differentiation (GO:0045624)3.44172905
30myeloid dendritic cell differentiation (GO:0043011)3.43047143
31interferon-gamma-mediated signaling pathway (GO:0060333)3.42995004
32oligosaccharide catabolic process (GO:0009313)3.41532925
33type I interferon signaling pathway (GO:0060337)3.40462741
34cellular response to type I interferon (GO:0071357)3.40462741
35regulation of interferon-alpha production (GO:0032647)3.36891658
36response to type I interferon (GO:0034340)3.35215500
37regulation of dendritic cell antigen processing and presentation (GO:0002604)3.30349245
38positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.28925699
39response to protozoan (GO:0001562)3.22415746
40positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.21141987
41negative regulation of myeloid cell apoptotic process (GO:0033033)3.19170466
42positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.18880922
43negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.18685791
44branching involved in labyrinthine layer morphogenesis (GO:0060670)3.17933990
45regulation of membrane protein ectodomain proteolysis (GO:0051043)3.17817675
46defense response to protozoan (GO:0042832)3.17192936
47regulation of heat generation (GO:0031650)3.15774944
48cellular response to lipopolysaccharide (GO:0071222)3.15586337
49negative regulation of nitric oxide biosynthetic process (GO:0045019)3.11100176
50negative regulation of cytokine production involved in immune response (GO:0002719)3.09821458
51regulation of interleukin-12 production (GO:0032655)3.09057334
52tryptophan catabolic process (GO:0006569)3.08323343
53indole-containing compound catabolic process (GO:0042436)3.08323343
54indolalkylamine catabolic process (GO:0046218)3.08323343
55adhesion of symbiont to host cell (GO:0044650)3.07409447
56virion attachment to host cell (GO:0019062)3.07409447
57ceramide catabolic process (GO:0046514)3.05606863
58cellular response to molecule of bacterial origin (GO:0071219)3.04730615
59kynurenine metabolic process (GO:0070189)3.03002620
60regulation of inflammatory response to antigenic stimulus (GO:0002861)3.02710597
61lymphocyte chemotaxis (GO:0048247)3.00853683
62membrane lipid catabolic process (GO:0046466)3.00330538
63negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.99026822
64cellular response to interferon-gamma (GO:0071346)2.98501515
65regulation of T cell tolerance induction (GO:0002664)2.97389284
66regulation of T-helper cell differentiation (GO:0045622)2.95998492
67response to interferon-gamma (GO:0034341)2.95762530
68regulation of type 2 immune response (GO:0002828)2.92810209
69detection of molecule of bacterial origin (GO:0032490)2.92804292
70regulation of macrophage chemotaxis (GO:0010758)2.92456458
71dendritic cell differentiation (GO:0097028)2.91440812
72sphingolipid catabolic process (GO:0030149)2.91414237
73positive regulation of antigen processing and presentation (GO:0002579)2.90598603
74regulation of nitric oxide biosynthetic process (GO:0045428)2.90394054
75positive regulation of acute inflammatory response (GO:0002675)2.89545931
76granulocyte activation (GO:0036230)2.88585654
77regulation of antigen processing and presentation (GO:0002577)2.87500312
78positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.86525260
79positive regulation of nitric oxide biosynthetic process (GO:0045429)2.85768006
80myeloid dendritic cell activation (GO:0001773)2.85694204
81positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.85137884
82germinal center formation (GO:0002467)2.83704473
83regulation of NF-kappaB import into nucleus (GO:0042345)2.83535985
84positive regulation of interferon-alpha production (GO:0032727)2.82656561
85regulation of T-helper 2 cell differentiation (GO:0045628)2.82322749
86positive regulation of toll-like receptor signaling pathway (GO:0034123)2.81889876
87regulation of interferon-beta biosynthetic process (GO:0045357)2.81301093
88positive regulation of interleukin-12 production (GO:0032735)2.81050953
89angiotensin maturation (GO:0002003)2.80876885
90regulation of immunoglobulin secretion (GO:0051023)2.79651918
91negative regulation of lipid storage (GO:0010888)2.79540094
92B cell mediated immunity (GO:0019724)2.78916623
93positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.77247855
94positive regulation of interleukin-6 production (GO:0032755)2.72504217
95positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.71429003
96positive regulation of interleukin-10 production (GO:0032733)2.70737125
97regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.70460762
98regulation of interleukin-8 biosynthetic process (GO:0045414)2.70320041
99cellular response to thyroid hormone stimulus (GO:0097067)2.68893611
100modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.68879969

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.84645657
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.15144682
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.65387873
4RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human4.48688434
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.32388767
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.60544722
7NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.34626163
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.30066482
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.10388091
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.99268365
11Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.88357080
12STAT4_19710469_ChIP-ChIP_TH1__Mouse2.52751733
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.44320772
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.43040951
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.32958635
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.15768675
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.11264165
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.10950547
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.08963234
20VDR_24787735_ChIP-Seq_THP-1_Human1.96915007
21SMAD_19615063_ChIP-ChIP_OVARY_Human1.91595610
22PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.73799058
23GATA1_22025678_ChIP-Seq_K562_Human1.68980701
24TP63_17297297_ChIP-ChIP_HaCaT_Human1.68142080
25STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.66199381
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.65308784
27CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.65009429
28BRD4_27068464_Chip-Seq_AML-cells_Mouse1.64969840
29VDR_24763502_ChIP-Seq_THP-1_Human1.62462647
30TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.58793737
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.58668502
32SPI1_23547873_ChIP-Seq_NB4_Human1.56491005
33SPI1_23127762_ChIP-Seq_K562_Human1.54480372
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.54362090
35SOX2_20726797_ChIP-Seq_SW620_Human1.49699120
36NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.48451055
37CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.46190475
38FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.43080863
39STAT6_21828071_ChIP-Seq_BEAS2B_Human1.42907409
40ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.36462033
41LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.36357577
42PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36172454
43RXR_22158963_ChIP-Seq_LIVER_Mouse1.36093194
44PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.34075344
45CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32623785
46CDX2_20551321_ChIP-Seq_CACO-2_Human1.32332404
47STAT1_20625510_ChIP-Seq_HELA_Human1.31972503
48ESR1_21235772_ChIP-Seq_MCF-7_Human1.30184239
49SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27082235
50LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.23564281
51NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.22537687
52PU_27001747_Chip-Seq_BMDM_Mouse1.21183582
53LXR_22158963_ChIP-Seq_LIVER_Mouse1.19125114
54PPARA_22158963_ChIP-Seq_LIVER_Mouse1.19106984
55GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.18919601
56E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.17165969
57PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16931144
58RUNX1_22412390_ChIP-Seq_EML_Mouse1.15029807
59CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.14280816
60RUNX_20019798_ChIP-Seq_JUKART_Human1.12390220
61VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11355389
62CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10675204
63VDR_21846776_ChIP-Seq_THP-1_Human1.09788249
64JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09167694
65GATA2_21666600_ChIP-Seq_HMVEC_Human1.08653192
66JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07615091
67LXR_22292898_ChIP-Seq_THP-1_Human1.06969429
68MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.06699868
69MYB_26560356_Chip-Seq_TH2_Human1.02191548
70SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.99582811
71CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.99459640
72BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97284775
73SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96988684
74PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96640192
75ELK3_25401928_ChIP-Seq_HUVEC_Human0.96571221
76GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96516762
77GATA1_19941826_ChIP-Seq_K562_Human0.96351357
78SCL_19346495_ChIP-Seq_HPC-7_Human0.96044229
79RARG_19884340_ChIP-ChIP_MEFs_Mouse0.94803908
80MAF_26560356_Chip-Seq_TH1_Human0.92420975
81EGR1_19032775_ChIP-ChIP_M12_Human0.92106498
82GATA4_25053715_ChIP-Seq_YYC3_Human0.90566799
83TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.88379022
84BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.87814959
85GATA3_26560356_Chip-Seq_TH2_Human0.86063896
86STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.84584221
87GATA1_19941827_ChIP-Seq_MEL_Mouse0.84054385
88FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.83878319
89THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.83560667
90FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.82008532
91TFEB_21752829_ChIP-Seq_HELA_Human0.81924133
92NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.80486359
93BCL6_27268052_Chip-Seq_Bcells_Human0.80485612
94VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.79200968
95KDM2B_26808549_Chip-Seq_SUP-B15_Human0.79062356
96EGR1_23403033_ChIP-Seq_LIVER_Mouse0.78450922
97BCOR_27268052_Chip-Seq_Bcells_Human0.78051393
98SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.77703860
99SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.77585832
100SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.77585832

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.93090157
2MP0002139_abnormal_hepatobiliary_system3.78420618
3MP0006082_CNS_inflammation3.68609940
4MP0002148_abnormal_hypersensitivity_rea3.59079604
5MP0009785_altered_susceptibility_to3.50134100
6MP0003724_increased_susceptibility_to3.26532262
7MP0009840_abnormal_foam_cell3.19215605
8MP0003436_decreased_susceptibility_to3.05090943
9MP0005058_abnormal_lysosome_morphology2.99747171
10MP0004510_myositis2.89926005
11MP0001835_abnormal_antigen_presentation2.71740269
12MP0009764_decreased_sensitivity_to2.52887411
13MP0005000_abnormal_immune_tolerance2.50686170
14MP0001790_abnormal_immune_system2.42031351
15MP0005387_immune_system_phenotype2.42031351
16MP0005025_abnormal_response_to2.40598007
17MP0003300_gastrointestinal_ulcer2.37154682
18MP0002419_abnormal_innate_immunity2.34844642
19MP0005671_abnormal_response_to2.33550054
20MP0003806_abnormal_nucleotide_metabolis2.23277898
21MP0003075_altered_response_to2.23275511
22MP0010155_abnormal_intestine_physiology2.19423655
23MP0000343_altered_response_to2.18297174
24MP0002452_abnormal_antigen_presenting2.00078875
25MP0002723_abnormal_immune_serum1.93127508
26MP0001533_abnormal_skeleton_physiology1.91422928
27MP0001800_abnormal_humoral_immune1.90409164
28MP0001845_abnormal_inflammatory_respons1.88307059
29MP0004947_skin_inflammation1.87888286
30MP0008004_abnormal_stomach_pH1.81148018
31MP0002254_reproductive_system_inflammat1.80051601
32MP0005166_decreased_susceptibility_to1.76125896
33MP0008469_abnormal_protein_level1.70108146
34MP0000685_abnormal_immune_system1.69692948
35MP0005167_abnormal_blood-brain_barrier1.67297876
36MP0005451_abnormal_body_composition1.66985733
37MP0000604_amyloidosis1.63493817
38MP0009278_abnormal_bone_marrow1.61839016
39MP0003453_abnormal_keratinocyte_physiol1.59339747
40MP0003195_calcinosis1.58337577
41MP0001853_heart_inflammation1.55198244
42MP0003191_abnormal_cellular_cholesterol1.54531823
43MP0006054_spinal_hemorrhage1.53582212
44MP0001819_abnormal_immune_cell1.52644576
45MP0003448_altered_tumor_morphology1.51606524
46MP0002420_abnormal_adaptive_immunity1.50192050
47MP0003172_abnormal_lysosome_physiology1.48967606
48MP0005310_abnormal_salivary_gland1.48810976
49MP0002998_abnormal_bone_remodeling1.46196592
50MP0002138_abnormal_hepatobiliary_system1.42619577
51MP0005397_hematopoietic_system_phenotyp1.33983106
52MP0001545_abnormal_hematopoietic_system1.33983106
53MP0003690_abnormal_glial_cell1.33781556
54MP0002405_respiratory_system_inflammati1.33649506
55MP0009333_abnormal_splenocyte_physiolog1.32607656
56MP0002332_abnormal_exercise_endurance1.21434660
57MP0001663_abnormal_digestive_system1.20473885
58MP0000858_altered_metastatic_potential1.18902544
59MP0001873_stomach_inflammation1.18862602
60MP0005365_abnormal_bile_salt1.17596354
61MP0010352_gastrointestinal_tract_polyps1.13985022
62MP0003656_abnormal_erythrocyte_physiolo1.11725202
63MP0003183_abnormal_peptide_metabolism1.10544731
64MP0005464_abnormal_platelet_physiology1.01875989
65MP0000716_abnormal_immune_system1.01744038
66MP0005164_abnormal_response_to1.01248504
67MP0005165_increased_susceptibility_to0.97123858
68MP0009763_increased_sensitivity_to0.92736707
69MP0010234_abnormal_vibrissa_follicle0.92309849
70MP0002277_abnormal_respiratory_mucosa0.92070937
71MP0009765_abnormal_xenobiotic_induced0.89786225
72MP0000920_abnormal_myelination0.87808342
73MP0004019_abnormal_vitamin_homeostasis0.86945388
74MP0001501_abnormal_sleep_pattern0.85771590
75MP0005360_urolithiasis0.83383969
76MP0005381_digestive/alimentary_phenotyp0.82932907
77MP0003329_amyloid_beta_deposits0.78549104
78MP0001542_abnormal_bone_strength0.74793959
79MP0005390_skeleton_phenotype0.74101521
80MP0003866_abnormal_defecation0.73330352
81MP0002429_abnormal_blood_cell0.73199625
82MP0000609_abnormal_liver_physiology0.71846027
83MP0008874_decreased_physiological_sensi0.71408819
84MP0002837_dystrophic_cardiac_calcinosis0.71046759
85MP0005319_abnormal_enzyme/_coenzyme0.70361679
86MP0005023_abnormal_wound_healing0.70116659
87MP0003091_abnormal_cell_migration0.69158233
88MP0002398_abnormal_bone_marrow0.68693725
89MP0000249_abnormal_blood_vessel0.68348436
90MP0005535_abnormal_body_temperature0.66992833
91MP0000490_abnormal_crypts_of0.66747904
92MP0003795_abnormal_bone_structure0.65951380
93MP0004043_abnormal_pH_regulation0.64128930
94MP0009643_abnormal_urine_homeostasis0.63024915
95MP0001666_abnormal_nutrient_absorption0.61830200
96MP0002136_abnormal_kidney_physiology0.61532529
97MP0001764_abnormal_homeostasis0.61259442
98MP0005647_abnormal_sex_gland0.60253085
99MP0002693_abnormal_pancreas_physiology0.58346846
100MP0000689_abnormal_spleen_morphology0.57839645

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycosphingolipid metabolism (HP:0004343)6.71182713
2Abnormality of glycolipid metabolism (HP:0010969)6.71182713
3Abnormality of liposaccharide metabolism (HP:0010968)6.71182713
4Systemic lupus erythematosus (HP:0002725)5.05921314
5Vacuolated lymphocytes (HP:0001922)5.03112363
6Abnormality of macrophages (HP:0004311)4.74646199
7Loss of speech (HP:0002371)4.47233791
8Disinhibition (HP:0000734)4.33436331
9Dysostosis multiplex (HP:0000943)4.09162401
10Orchitis (HP:0100796)4.06061991
11Optic neuritis (HP:0100653)3.97139910
12Retrobulbar optic neuritis (HP:0100654)3.97139910
13Increased cerebral lipofuscin (HP:0011813)3.95678314
14Recurrent bacterial skin infections (HP:0005406)3.92536311
15Eczematoid dermatitis (HP:0000976)3.87269637
16Stomatitis (HP:0010280)3.61323466
17Mutism (HP:0002300)3.58672576
18Autoimmune thrombocytopenia (HP:0001973)3.57385819
19Malnutrition (HP:0004395)3.53608477
20Recurrent abscess formation (HP:0002722)3.51855107
21Myositis (HP:0100614)3.50197995
22Neurofibrillary tangles (HP:0002185)3.47391002
23Glomerulonephritis (HP:0000099)3.30251823
24Increased neuronal autofluorescent lipopigment (HP:0002074)3.20399891
25Mediastinal lymphadenopathy (HP:0100721)3.19543287
26Nuclear cataract (HP:0100018)3.18964498
27Abnormality of polysaccharide metabolism (HP:0011012)3.17920224
28Abnormality of glycosaminoglycan metabolism (HP:0004371)3.17920224
29Abnormality of mucopolysaccharide metabolism (HP:0011020)3.17920224
30Axonal loss (HP:0003447)3.14410608
31Nausea (HP:0002018)3.03689429
32Urinary glycosaminoglycan excretion (HP:0003541)3.03405919
33Mucopolysacchariduria (HP:0008155)3.03405919
34Amyloidosis (HP:0011034)2.97939588
35Keratoconjunctivitis sicca (HP:0001097)2.73292280
36Metaphyseal irregularity (HP:0003025)2.72969109
37Recurrent gram-negative bacterial infections (HP:0005420)2.72141252
38Hematochezia (HP:0002573)2.71922309
39Pulmonary infiltrates (HP:0002113)2.66762565
40Increased serum ferritin (HP:0003281)2.64322704
41Vasculitis (HP:0002633)2.61149465
42Apathy (HP:0000741)2.59655729
43Gangrene (HP:0100758)2.56436191
44Hemoptysis (HP:0002105)2.54517830
45Diminished motivation (HP:0000745)2.53795628
46Progressive neurologic deterioration (HP:0002344)2.52187506
47Abnormality of the vasculature of the conjunctiva (HP:0008054)2.50603009
48Keratoconjunctivitis (HP:0001096)2.49947125
49Myocardial infarction (HP:0001658)2.49902425
50Increased IgM level (HP:0003496)2.49891625
51Complement deficiency (HP:0004431)2.49026720
52Petechiae (HP:0000967)2.41427677
53Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.35053220
54Prolonged neonatal jaundice (HP:0006579)2.31112949
55Cerebral inclusion bodies (HP:0100314)2.30762966
56Elevated erythrocyte sedimentation rate (HP:0003565)2.30234409
57Obstructive lung disease (HP:0006536)2.29303060
58Chronic obstructive pulmonary disease (HP:0006510)2.29303060
59Inappropriate behavior (HP:0000719)2.28806218
60Gastrointestinal infarctions (HP:0005244)2.28647335
61Polyneuropathy (HP:0001271)2.17679014
62Interstitial pulmonary disease (HP:0006530)2.17433081
63Abnormality of iron homeostasis (HP:0011031)2.17259310
64Thin bony cortex (HP:0002753)2.15522995
65Neuronal loss in central nervous system (HP:0002529)2.11358747
66Abnormality of complement system (HP:0005339)2.10491358
67Bone pain (HP:0002653)2.09310425
68Purpura (HP:0000979)2.08719190
69Basal ganglia calcification (HP:0002135)2.06046187
70Hyperparathyroidism (HP:0000843)2.05990180
71Anorexia (HP:0002039)2.04889047
72Recurrent skin infections (HP:0001581)2.04735501
73Parakeratosis (HP:0001036)2.04448528
74Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.03931047
75Gingivitis (HP:0000230)2.01479383
76Dementia (HP:0000726)2.01215608
77Abnormality of glutamine family amino acid metabolism (HP:0010902)1.99672449
78Agnosia (HP:0010524)1.99301042
79Chronic diarrhea (HP:0002028)1.98921044
80Autoimmune hemolytic anemia (HP:0001890)1.98219234
81Hypophosphatemia (HP:0002148)1.98180074
82Premature loss of primary teeth (HP:0006323)1.96572446
83Hepatosplenomegaly (HP:0001433)1.94686308
84Joint swelling (HP:0001386)1.94651787
85Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.92701327
86Abnormality of the pleura (HP:0002103)1.89934754
87Steatorrhea (HP:0002570)1.89463808
88Hypergammaglobulinemia (HP:0010702)1.87581670
89Recurrent viral infections (HP:0004429)1.86734994
90Protuberant abdomen (HP:0001538)1.86427566
91Nephritis (HP:0000123)1.84615143
92Fat malabsorption (HP:0002630)1.82178695
93T lymphocytopenia (HP:0005403)1.82013314
94Pancreatitis (HP:0001733)1.81752771
95Urticaria (HP:0001025)1.80867037
96Acne (HP:0001061)1.80197067
97Recurrent fungal infections (HP:0002841)1.80004665
98Abnormality of the nasal mucosa (HP:0000433)1.79955461
99Peripheral demyelination (HP:0011096)1.79518073
100Asymmetric septal hypertrophy (HP:0001670)1.78558333

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK35.98450834
2NME24.07866026
3GRK73.48998627
4MAP3K143.39306795
5ACVR1B3.06965188
6DDR22.98292245
7MATK2.84665985
8TAOK22.74201581
9TBK12.68891618
10RIPK12.52710812
11BLK2.48878049
12TYK22.21936732
13IKBKB2.20298155
14TAOK12.15761190
15IKBKE1.98015803
16RIPK41.96895957
17PIM21.92790547
18IRAK41.92170457
19MAP3K111.90047789
20ERN11.87428897
21ADRBK21.83764368
22FGR1.82981916
23MAP3K31.80108620
24BMPR21.73270869
25CSK1.72381241
26TGFBR21.58650635
27MOS1.53763813
28TXK1.46745480
29CDC42BPA1.42695078
30PRPF4B1.41466854
31ABL21.41328499
32MAP4K11.40255591
33JAK31.36644632
34CHUK1.36554116
35MAP3K131.19295812
36MAP3K11.16578555
37JAK11.04416078
38LYN1.02580510
39MST1R1.00349841
40IRAK11.00258276
41STK240.96217096
42ZAP700.93158681
43MAP2K30.91678418
44MAP2K60.91488061
45MAP3K50.89374559
46IRAK20.88933287
47PRKG20.85785253
48LMTK20.83802993
49TESK10.79574892
50JAK20.78377384
51MAP3K120.76873521
52DAPK20.68539300
53LATS20.65635850
54SYK0.65516924
55EPHA30.65251779
56ARAF0.63760403
57TESK20.61835208
58SIK30.61698010
59CSF1R0.61068395
60PDK20.59477992
61MST40.57563958
62TAOK30.53689235
63PIM10.52942050
64TYRO30.52849236
65LCK0.50559148
66MARK30.49078096
67STK100.45972976
68KIT0.45473041
69PAK40.45452021
70CAMKK20.41485323
71BMX0.39807381
72PDPK10.37316575
73DAPK30.36809823
74CLK10.36768308
75HCK0.35919250
76EPHA20.33957409
77PDGFRA0.33701225
78EPHB20.31980003
79ABL10.31600751
80EPHB10.31506681
81DYRK30.31307177
82CDK60.31165275
83MAPK40.31029315
84PDK10.30498117
85HIPK20.28416711
86BTK0.25089068
87FGFR40.24278359
88RPS6KL10.23847413
89RPS6KC10.23847413
90PRKAA20.23321784
91EGFR0.22875350
92PRKCD0.22578631
93CAMK2D0.20793190
94GSK3A0.20565849
95INSR0.19897627
96PRKACG0.18738625
97CAMK2G0.16999338
98RPS6KA60.16776567
99MAPKAPK20.16696074
100FYN0.16580209

Predicted pathways (KEGG)

RankGene SetZ-score
1Rheumatoid arthritis_Homo sapiens_hsa053233.08889616
2Allograft rejection_Homo sapiens_hsa053302.93818353
3Asthma_Homo sapiens_hsa053102.93127135
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.88133644
5Staphylococcus aureus infection_Homo sapiens_hsa051502.61832168
6Graft-versus-host disease_Homo sapiens_hsa053322.56394517
7Other glycan degradation_Homo sapiens_hsa005112.55696525
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.50961537
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.46361043
10Leishmaniasis_Homo sapiens_hsa051402.37363500
11NOD-like receptor signaling pathway_Homo sapiens_hsa046212.35415487
12Type I diabetes mellitus_Homo sapiens_hsa049402.28023543
13Pertussis_Homo sapiens_hsa051332.27750026
14Osteoclast differentiation_Homo sapiens_hsa043802.25727509
15Autoimmune thyroid disease_Homo sapiens_hsa053202.22910058
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.17068366
17TNF signaling pathway_Homo sapiens_hsa046682.16903158
18Legionellosis_Homo sapiens_hsa051342.16873535
19Lysosome_Homo sapiens_hsa041422.12557722
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.05031825
21Malaria_Homo sapiens_hsa051442.03115993
22Tuberculosis_Homo sapiens_hsa051521.96059275
23African trypanosomiasis_Homo sapiens_hsa051431.94618311
24Sulfur metabolism_Homo sapiens_hsa009201.86995313
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.77435523
26Salmonella infection_Homo sapiens_hsa051321.73983868
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.72185687
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.69088334
29Mineral absorption_Homo sapiens_hsa049781.68081993
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.66393829
31Influenza A_Homo sapiens_hsa051641.64707451
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.52743961
33Toxoplasmosis_Homo sapiens_hsa051451.49828120
34Antigen processing and presentation_Homo sapiens_hsa046121.38074699
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.32888916
36Hematopoietic cell lineage_Homo sapiens_hsa046401.20802431
37Phagosome_Homo sapiens_hsa041451.19653222
38Hepatitis C_Homo sapiens_hsa051601.16848391
39Viral myocarditis_Homo sapiens_hsa054161.15820295
40Herpes simplex infection_Homo sapiens_hsa051681.14307130
41Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.10546077
42Chemokine signaling pathway_Homo sapiens_hsa040621.09972659
43Collecting duct acid secretion_Homo sapiens_hsa049660.99605550
44Measles_Homo sapiens_hsa051620.98948664
45Prion diseases_Homo sapiens_hsa050200.96282115
46Sphingolipid metabolism_Homo sapiens_hsa006000.93587293
47Jak-STAT signaling pathway_Homo sapiens_hsa046300.91524328
48Tryptophan metabolism_Homo sapiens_hsa003800.85646606
49Renin-angiotensin system_Homo sapiens_hsa046140.82153778
50Shigellosis_Homo sapiens_hsa051310.81458037
51Bladder cancer_Homo sapiens_hsa052190.77073761
52B cell receptor signaling pathway_Homo sapiens_hsa046620.75233552
53PPAR signaling pathway_Homo sapiens_hsa033200.74931038
54Amoebiasis_Homo sapiens_hsa051460.74909086
55Galactose metabolism_Homo sapiens_hsa000520.73440334
56Apoptosis_Homo sapiens_hsa042100.70932170
57Adipocytokine signaling pathway_Homo sapiens_hsa049200.70868457
58Hepatitis B_Homo sapiens_hsa051610.69306515
59Complement and coagulation cascades_Homo sapiens_hsa046100.67051554
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66579954
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63618454
62Fructose and mannose metabolism_Homo sapiens_hsa000510.59966705
63Vibrio cholerae infection_Homo sapiens_hsa051100.58229313
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56060563
65Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.53703939
66Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.53344754
67Vitamin digestion and absorption_Homo sapiens_hsa049770.51458270
68Fat digestion and absorption_Homo sapiens_hsa049750.51346868
69Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49934238
70Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44578775
71Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43219924
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.42332912
73Epstein-Barr virus infection_Homo sapiens_hsa051690.42052664
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41327983
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39513052
76Glutathione metabolism_Homo sapiens_hsa004800.39246110
77Prolactin signaling pathway_Homo sapiens_hsa049170.38878197
78T cell receptor signaling pathway_Homo sapiens_hsa046600.37873675
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.35214326
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34845926
81Acute myeloid leukemia_Homo sapiens_hsa052210.32943037
82Primary immunodeficiency_Homo sapiens_hsa053400.31931443
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.30831183
84Type II diabetes mellitus_Homo sapiens_hsa049300.27062860
85Ether lipid metabolism_Homo sapiens_hsa005650.24498090
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.23199898
87Folate biosynthesis_Homo sapiens_hsa007900.22951925
88Arachidonic acid metabolism_Homo sapiens_hsa005900.22521722
89Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.21405035
90VEGF signaling pathway_Homo sapiens_hsa043700.21224816
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.20842584
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.20136358
93Starch and sucrose metabolism_Homo sapiens_hsa005000.18962896
94Chemical carcinogenesis_Homo sapiens_hsa052040.18222532
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.17804641
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.16109033
97Systemic lupus erythematosus_Homo sapiens_hsa053220.16098074
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.15740161
99Protein digestion and absorption_Homo sapiens_hsa049740.15647008
100HIF-1 signaling pathway_Homo sapiens_hsa040660.14418284

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