C14ORF93

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA methylation involved in gamete generation (GO:0043046)4.40625235
2negative regulation of phagocytosis (GO:0050765)3.97927058
3piRNA metabolic process (GO:0034587)3.83326805
4positive regulation of granulocyte differentiation (GO:0030854)3.79787851
5preassembly of GPI anchor in ER membrane (GO:0016254)3.62428265
6respiratory chain complex IV assembly (GO:0008535)3.62282319
7peptidyl-histidine modification (GO:0018202)3.57078681
8synapsis (GO:0007129)3.47702489
9regulation of B cell apoptotic process (GO:0002902)3.45835150
10positive regulation of B cell differentiation (GO:0045579)3.25337984
11positive regulation by organism of defense response of other organism involved in symbiotic interact3.24991125
12modulation by symbiont of host immune response (GO:0052553)3.24991125
13positive regulation by symbiont of host defense response (GO:0052509)3.24991125
14modulation by symbiont of host defense response (GO:0052031)3.24991125
15modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.24991125
16modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.24991125
17cytochrome complex assembly (GO:0017004)3.22416726
18positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.18932720
19deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.16776802
20positive regulation of gamma-delta T cell activation (GO:0046645)3.04390210
21kinetochore assembly (GO:0051382)2.98592052
22GPI anchor biosynthetic process (GO:0006506)2.95854001
23pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.93733008
24neutrophil activation involved in immune response (GO:0002283)2.81886653
25DNA deamination (GO:0045006)2.79776642
26branched-chain amino acid catabolic process (GO:0009083)2.78948831
27keratinocyte development (GO:0003334)2.78500634
28regulation of vacuole organization (GO:0044088)2.77465540
29kinetochore organization (GO:0051383)2.75384015
30positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.73293590
31C-terminal protein lipidation (GO:0006501)2.70409957
32regulation of autophagic vacuole assembly (GO:2000785)2.70138215
33T cell homeostasis (GO:0043029)2.68269022
34GPI anchor metabolic process (GO:0006505)2.62313186
35inositol phosphate catabolic process (GO:0071545)2.61878694
36poly(A)+ mRNA export from nucleus (GO:0016973)2.60478867
37regulation of granulocyte differentiation (GO:0030852)2.58436570
38branched-chain amino acid metabolic process (GO:0009081)2.58360204
39protein import into peroxisome matrix (GO:0016558)2.56979968
40DNA synthesis involved in DNA repair (GO:0000731)2.54233034
41regulation of oxidative stress-induced neuron death (GO:1903203)2.53146844
42oxygen transport (GO:0015671)2.51115089
43histone H4-K16 acetylation (GO:0043984)2.48432382
44water-soluble vitamin biosynthetic process (GO:0042364)2.48112024
453-UTR-mediated mRNA stabilization (GO:0070935)2.47522304
46response to peptidoglycan (GO:0032494)2.47365066
47resolution of meiotic recombination intermediates (GO:0000712)2.44779989
48male meiosis I (GO:0007141)2.42593106
49rRNA modification (GO:0000154)2.41958440
50ribosome assembly (GO:0042255)2.41868531
51definitive hemopoiesis (GO:0060216)2.38540305
52valine metabolic process (GO:0006573)2.37464610
53regulation of interferon-beta biosynthetic process (GO:0045357)2.36928904
54erythrocyte maturation (GO:0043249)2.36619644
55negative regulation of erythrocyte differentiation (GO:0045647)2.34744705
56protein complex biogenesis (GO:0070271)2.32912300
57pyrimidine nucleotide catabolic process (GO:0006244)2.32391916
58leukocyte migration involved in inflammatory response (GO:0002523)2.31058598
59leukocyte degranulation (GO:0043299)2.28620159
60positive regulation of histone H3-K4 methylation (GO:0051571)2.27766883
61mitochondrial respiratory chain complex assembly (GO:0033108)2.26280620
62histone H2A acetylation (GO:0043968)2.25852139
63RNA methylation (GO:0001510)2.25360140
64response to host immune response (GO:0052572)2.23342342
65response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.23342342
66mitochondrial respiratory chain complex I assembly (GO:0032981)2.23303264
67NADH dehydrogenase complex assembly (GO:0010257)2.23303264
68mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.23303264
69megakaryocyte development (GO:0035855)2.22636272
70positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.22270074
71tRNA modification (GO:0006400)2.21423628
72somatic hypermutation of immunoglobulin genes (GO:0016446)2.20199925
73somatic diversification of immune receptors via somatic mutation (GO:0002566)2.20199925
74tRNA methylation (GO:0030488)2.19989047
75regulation of histone H3-K4 methylation (GO:0051569)2.19657322
76phosphorylated carbohydrate dephosphorylation (GO:0046838)2.19275111
77inositol phosphate dephosphorylation (GO:0046855)2.19275111
78DNA catabolic process, endonucleolytic (GO:0000737)2.19176394
79regulation of gamma-delta T cell activation (GO:0046643)2.18349419
80phosphatidylethanolamine biosynthetic process (GO:0006646)2.18111927
81pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.17225704
82mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.16961957
83positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.16961957
84polyol catabolic process (GO:0046174)2.16483436
85meiosis I (GO:0007127)2.14417005
86protoporphyrinogen IX metabolic process (GO:0046501)2.14321005
87RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.13120274
88regulation of B cell differentiation (GO:0045577)2.11831462
89mast cell activation involved in immune response (GO:0002279)2.10321298
90mast cell degranulation (GO:0043303)2.10321298
91negative regulation of T cell apoptotic process (GO:0070233)2.09981828
92DNA double-strand break processing (GO:0000729)2.09669027
93negative regulation of translational initiation (GO:0045947)2.09183431
94negative regulation of B cell apoptotic process (GO:0002903)2.08859839
95negative regulation of cell size (GO:0045792)2.08081676
96negative regulation of stem cell proliferation (GO:2000647)2.08074688
97C-terminal protein amino acid modification (GO:0018410)2.07778542
98rRNA methylation (GO:0031167)2.07729217
99production of molecular mediator involved in inflammatory response (GO:0002532)2.07676217
100regulation of gamma-delta T cell differentiation (GO:0045586)2.06992677

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.55752038
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.12988275
3HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.75380258
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.75117005
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.67996813
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.66789958
7ELF1_17652178_ChIP-ChIP_JURKAT_Human2.57435368
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.50631953
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.47839969
10SRF_21415370_ChIP-Seq_HL-1_Mouse2.44544961
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.38164994
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.22956100
13VDR_23849224_ChIP-Seq_CD4+_Human2.20062271
14FOXP3_21729870_ChIP-Seq_TREG_Human2.18209901
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.17973202
16SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.11663720
17CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.09824466
18CIITA_25753668_ChIP-Seq_RAJI_Human2.08122413
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.02132979
20FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.01730075
21GABP_19822575_ChIP-Seq_HepG2_Human2.01296147
22KDM5A_27292631_Chip-Seq_BREAST_Human1.98017456
23SPI1_23547873_ChIP-Seq_NB4_Human1.91350926
24DCP1A_22483619_ChIP-Seq_HELA_Human1.89382297
25MYC_22102868_ChIP-Seq_BL_Human1.83884536
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83569011
27HOXB4_20404135_ChIP-ChIP_EML_Mouse1.83260200
28SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.82251400
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.82238019
30ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.81386195
31VDR_21846776_ChIP-Seq_THP-1_Human1.74149004
32CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.72571377
33IGF1R_20145208_ChIP-Seq_DFB_Human1.71065680
34IRF8_21731497_ChIP-ChIP_J774_Mouse1.66543512
35YY1_21170310_ChIP-Seq_MESCs_Mouse1.64902010
36MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.64467497
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.64191220
38IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.63704098
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.63221127
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.62364597
41EGR1_19374776_ChIP-ChIP_THP-1_Human1.59008616
42SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.58493092
43MAF_26560356_Chip-Seq_TH2_Human1.56937973
44ZNF263_19887448_ChIP-Seq_K562_Human1.56032824
45ERG_20887958_ChIP-Seq_HPC-7_Mouse1.49009360
46FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.48159208
47MYC_18358816_ChIP-ChIP_MESCs_Mouse1.46191890
48ZNF274_21170338_ChIP-Seq_K562_Hela1.45855671
49MYB_26560356_Chip-Seq_TH1_Human1.42827340
50GATA1_22025678_ChIP-Seq_K562_Human1.41051587
51NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.40029134
52MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.38064411
53XRN2_22483619_ChIP-Seq_HELA_Human1.37969936
54E2F7_22180533_ChIP-Seq_HELA_Human1.37503645
55BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.37255227
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.36396927
57MYC_18555785_ChIP-Seq_MESCs_Mouse1.32966826
58* MAF_26560356_Chip-Seq_TH1_Human1.32020911
59GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.31483126
60* UTX_26944678_Chip-Seq_JUKART_Human1.31053741
61CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.27932365
62* MYB_26560356_Chip-Seq_TH2_Human1.27859539
63RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.27381487
64MYC_19030024_ChIP-ChIP_MESCs_Mouse1.26408894
65TFEB_21752829_ChIP-Seq_HELA_Human1.26190622
66DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.25179643
67YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22670376
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.22254483
69* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.21503925
70SCL_19346495_ChIP-Seq_HPC-7_Human1.17208416
71GATA3_27048872_Chip-Seq_THYMUS_Human1.15240651
72CREB1_15753290_ChIP-ChIP_HEK293T_Human1.14577498
73LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.14530972
74E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.11999598
75TTF2_22483619_ChIP-Seq_HELA_Human1.09663879
76FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09461971
77PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08540033
78E2F4_17652178_ChIP-ChIP_JURKAT_Human1.08314978
79TP63_19390658_ChIP-ChIP_HaCaT_Human1.07891636
80TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07535214
81IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.06751793
82NCOR1_26117541_ChIP-Seq_K562_Human1.04903906
83VDR_24763502_ChIP-Seq_THP-1_Human1.04855516
84EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.04197709
85ELK1_19687146_ChIP-ChIP_HELA_Human1.02220354
86MYCN_18555785_ChIP-Seq_MESCs_Mouse1.01894131
87EGR1_23403033_ChIP-Seq_LIVER_Mouse1.01882028
88ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01711672
89MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.99543789
90SPI1_23127762_ChIP-Seq_K562_Human0.98922317
91HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.97269151
92CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.96088748
93BCL6_27268052_Chip-Seq_Bcells_Human0.95778191
94ELF1_20517297_ChIP-Seq_JURKAT_Human0.94007367
95SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.93397342
96LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.92075470
97E2F1_18555785_ChIP-Seq_MESCs_Mouse0.91973798
98FOXP1_21924763_ChIP-Seq_HESCs_Human0.90578084
99E2F1_20622854_ChIP-Seq_HELA_Human0.88800955
100STAT4_19710469_ChIP-ChIP_TH1__Mouse0.87487940

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002132_abnormal_respiratory_system3.78906036
2MP0003806_abnormal_nucleotide_metabolis3.25701860
3MP0003656_abnormal_erythrocyte_physiolo3.09071937
4MP0009697_abnormal_copulation2.81540584
5MP0008058_abnormal_DNA_repair2.63545900
6MP0002396_abnormal_hematopoietic_system2.40184225
7MP0003724_increased_susceptibility_to2.11103530
8MP0006035_abnormal_mitochondrial_morpho2.04677336
9MP0005075_abnormal_melanosome_morpholog1.99503536
10MP0006036_abnormal_mitochondrial_physio1.95941934
11MP0001661_extended_life_span1.94453546
12MP0010094_abnormal_chromosome_stability1.91011056
13MP0000685_abnormal_immune_system1.90646705
14MP0003172_abnormal_lysosome_physiology1.84701105
15MP0005365_abnormal_bile_salt1.74836103
16MP0008877_abnormal_DNA_methylation1.72576243
17MP0002653_abnormal_ependyma_morphology1.72026279
18MP0001764_abnormal_homeostasis1.71984516
19MP0001835_abnormal_antigen_presentation1.70189639
20MP0000372_irregular_coat_pigmentation1.69575740
21MP0008995_early_reproductive_senescence1.69513383
22MP0005083_abnormal_biliary_tract1.67895700
23MP0005451_abnormal_body_composition1.67361826
24MP0002722_abnormal_immune_system1.56532124
25MP0005058_abnormal_lysosome_morphology1.55903292
26MP0000689_abnormal_spleen_morphology1.55625311
27MP0005397_hematopoietic_system_phenotyp1.55553223
28MP0001545_abnormal_hematopoietic_system1.55553223
29MP0000703_abnormal_thymus_morphology1.54506169
30MP0003786_premature_aging1.49597469
31MP0003436_decreased_susceptibility_to1.46309912
32MP0002160_abnormal_reproductive_system1.44727321
33MP0005084_abnormal_gallbladder_morpholo1.42282478
34MP0002837_dystrophic_cardiac_calcinosis1.41916096
35MP0002398_abnormal_bone_marrow1.41765602
36MP0001800_abnormal_humoral_immune1.41462295
37MP0005367_renal/urinary_system_phenotyp1.40865878
38MP0000516_abnormal_urinary_system1.40865878
39MP0003693_abnormal_embryo_hatching1.38065791
40MP0005379_endocrine/exocrine_gland_phen1.37038375
41MP0005464_abnormal_platelet_physiology1.35662823
42MP0002419_abnormal_innate_immunity1.28612124
43MP0005220_abnormal_exocrine_pancreas1.28289996
44MP0003763_abnormal_thymus_physiology1.25950913
45MP0002723_abnormal_immune_serum1.23628007
46MP0004808_abnormal_hematopoietic_stem1.23092678
47MP0001929_abnormal_gametogenesis1.20269581
48MP0003186_abnormal_redox_activity1.19772124
49MP0002420_abnormal_adaptive_immunity1.18237985
50MP0008875_abnormal_xenobiotic_pharmacok1.18002640
51MP0005332_abnormal_amino_acid1.17405900
52MP0003195_calcinosis1.16111972
53MP0005025_abnormal_response_to1.15753769
54MP0001819_abnormal_immune_cell1.15682812
55MP0000716_abnormal_immune_system1.11922555
56MP0010234_abnormal_vibrissa_follicle1.11878933
57MP0002429_abnormal_blood_cell1.09413562
58MP0008260_abnormal_autophagy1.09113141
59MP0004381_abnormal_hair_follicle1.08428843
60MP0008007_abnormal_cellular_replicative1.08351964
61MP0003077_abnormal_cell_cycle1.05644270
62MP0001145_abnormal_male_reproductive1.05502200
63MP0010329_abnormal_lipoprotein_level1.05336500
64MP0002210_abnormal_sex_determination1.05181032
65MP0006054_spinal_hemorrhage1.04838989
66MP0003943_abnormal_hepatobiliary_system1.04467316
67MP0002452_abnormal_antigen_presenting1.02987032
68MP0005174_abnormal_tail_pigmentation1.02575432
69MP0002166_altered_tumor_susceptibility1.01883612
70MP0001944_abnormal_pancreas_morphology0.99926955
71MP0002405_respiratory_system_inflammati0.99586531
72MP0000609_abnormal_liver_physiology0.98988646
73MP0005389_reproductive_system_phenotype0.98633523
74MP0009785_altered_susceptibility_to0.98536615
75MP0005387_immune_system_phenotype0.97512223
76MP0001790_abnormal_immune_system0.97512223
77MP0003698_abnormal_male_reproductive0.96488247
78MP0003111_abnormal_nucleus_morphology0.95914271
79MP0000653_abnormal_sex_gland0.95580693
80MP0005085_abnormal_gallbladder_physiolo0.95099149
81MP0002138_abnormal_hepatobiliary_system0.94991256
82MP0000313_abnormal_cell_death0.94387623
83MP0008469_abnormal_protein_level0.94330399
84MP0000358_abnormal_cell_content/0.94092306
85MP0002693_abnormal_pancreas_physiology0.93856573
86MP0003122_maternal_imprinting0.91926172
87MP0002139_abnormal_hepatobiliary_system0.91063328
88MP0000598_abnormal_liver_morphology0.90795074
89MP0005000_abnormal_immune_tolerance0.90209601
90MP0002019_abnormal_tumor_incidence0.89247089
91MP0002127_abnormal_cardiovascular_syste0.89244169
92MP0009333_abnormal_splenocyte_physiolog0.85643397
93MP0008057_abnormal_DNA_replication0.85305401
94MP0002277_abnormal_respiratory_mucosa0.85122831
95MP0001986_abnormal_taste_sensitivity0.79343256
96MP0000465_gastrointestinal_hemorrhage0.78304019
97MP0009115_abnormal_fat_cell0.76643304
98MP0005319_abnormal_enzyme/_coenzyme0.74581927
99MP0005376_homeostasis/metabolism_phenot0.73782704
100MP0001984_abnormal_olfaction0.71771418

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)4.31556027
2Cutaneous melanoma (HP:0012056)4.26204946
3Abnormality of long-chain fatty-acid metabolism (HP:0010964)4.04334571
4Panhypogammaglobulinemia (HP:0003139)3.87736406
5Microvesicular hepatic steatosis (HP:0001414)3.39640956
6Squamous cell carcinoma (HP:0002860)3.26606292
7Abnormality of DNA repair (HP:0003254)3.12167442
8Abnormal delayed hypersensitivity skin test (HP:0002963)3.08884099
9Dyschromatopsia (HP:0007641)2.90043890
10Neoplasm of the adrenal cortex (HP:0100641)2.79591740
11Stomatitis (HP:0010280)2.71777909
12Abnormality of fatty-acid metabolism (HP:0004359)2.70666743
13Poikiloderma (HP:0001029)2.63099950
14Hepatocellular necrosis (HP:0001404)2.58130019
15Acute hepatic failure (HP:0006554)2.56726925
16Ketosis (HP:0001946)2.53732202
17Brushfield spots (HP:0001088)2.51194916
18Prolonged bleeding time (HP:0003010)2.50609649
19True hermaphroditism (HP:0010459)2.47374841
20Recurrent abscess formation (HP:0002722)2.47371832
21Recurrent fungal infections (HP:0002841)2.41092186
22Reticulocytosis (HP:0001923)2.39751727
23Hypochromic microcytic anemia (HP:0004840)2.37896963
24Recurrent bacterial skin infections (HP:0005406)2.32279806
25Asymmetry of the thorax (HP:0001555)2.32225807
26Type 2 muscle fiber atrophy (HP:0003554)2.31346962
27Cheilitis (HP:0100825)2.24592269
28Recurrent gram-negative bacterial infections (HP:0005420)2.24558487
29Basal cell carcinoma (HP:0002671)2.23665964
30Hepatic necrosis (HP:0002605)2.22896900
31Hypochromic anemia (HP:0001931)2.22590157
32Thyroiditis (HP:0100646)2.21973143
33Severe combined immunodeficiency (HP:0004430)2.21225605
34Hypoplastic pelvis (HP:0008839)2.21175357
35Lipid accumulation in hepatocytes (HP:0006561)2.18799270
36Reduced antithrombin III activity (HP:0001976)2.18684572
37Renal Fanconi syndrome (HP:0001994)2.14863600
38Osteomalacia (HP:0002749)2.13791215
39Granulocytopenia (HP:0001913)2.13595744
40Absent rod-and cone-mediated responses on ERG (HP:0007688)2.05849470
41Chronic mucocutaneous candidiasis (HP:0002728)2.05043607
42Recurrent cutaneous fungal infections (HP:0011370)2.05043607
43Easy fatigability (HP:0003388)2.04094706
44Episodic fever (HP:0001954)2.04052289
45Abnormal ciliary motility (HP:0012262)2.03743609
46Recurrent skin infections (HP:0001581)2.03324673
47Cholelithiasis (HP:0001081)1.99940455
48Muscle fiber atrophy (HP:0100295)1.98286912
49Poor suck (HP:0002033)1.93961037
50Pancreatic islet-cell hyperplasia (HP:0004510)1.92687310
51Joint hemorrhage (HP:0005261)1.91883726
52Acute lymphatic leukemia (HP:0006721)1.90913663
53Abnormal gallbladder morphology (HP:0012437)1.90896731
54Spastic paraparesis (HP:0002313)1.90629715
55Increased CSF lactate (HP:0002490)1.89491580
56Chronic obstructive pulmonary disease (HP:0006510)1.88346444
57Obstructive lung disease (HP:0006536)1.88346444
58Elevated erythrocyte sedimentation rate (HP:0003565)1.88255153
59Absent thumb (HP:0009777)1.87622124
60Abnormality of the pancreatic islet cells (HP:0006476)1.87365297
61Abnormality of endocrine pancreas physiology (HP:0012093)1.87365297
62Abnormality of aromatic amino acid family metabolism (HP:0004338)1.87107454
63Cholecystitis (HP:0001082)1.85301987
64Abnormal gallbladder physiology (HP:0012438)1.85301987
65Increased serum lactate (HP:0002151)1.85194080
66Abnormality of T cell physiology (HP:0011840)1.84491331
67Mitochondrial inheritance (HP:0001427)1.84255437
68Fetal akinesia sequence (HP:0001989)1.83499418
69Ketoacidosis (HP:0001993)1.83376271
70Abnormality of pyrimidine metabolism (HP:0004353)1.83213952
71Microcytic anemia (HP:0001935)1.82965132
72Abnormality of reticulocytes (HP:0004312)1.80218926
73Pancreatic cysts (HP:0001737)1.79894261
74Large for gestational age (HP:0001520)1.78660526
75B lymphocytopenia (HP:0010976)1.78655655
76Gingival bleeding (HP:0000225)1.76654485
77Neutropenia (HP:0001875)1.76514075
78Abnormality of macrophages (HP:0004311)1.76067545
79Combined immunodeficiency (HP:0005387)1.75623380
80Sex reversal (HP:0012245)1.74720275
81Abnormal sex determination (HP:0012244)1.74720275
82Eosinophilia (HP:0001880)1.74526502
83Epiphyseal stippling (HP:0010655)1.73459484
84Gastrointestinal inflammation (HP:0004386)1.72466609
85Intestinal atresia (HP:0011100)1.71211556
86Progressive macrocephaly (HP:0004481)1.70590135
87Dicarboxylic aciduria (HP:0003215)1.70588131
88Abnormality of dicarboxylic acid metabolism (HP:0010995)1.70588131
89Hyperammonemia (HP:0001987)1.70431344
90Type I transferrin isoform profile (HP:0003642)1.69030324
91Popliteal pterygium (HP:0009756)1.67786742
92Abnormal protein N-linked glycosylation (HP:0012347)1.67736518
93Abnormal protein glycosylation (HP:0012346)1.67736518
94Abnormal glycosylation (HP:0012345)1.67736518
95Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.67736518
96Cutaneous photosensitivity (HP:0000992)1.66013820
97Abnormal rod and cone electroretinograms (HP:0008323)1.65190154
98Myelodysplasia (HP:0002863)1.64844735
99Abnormality of B cell number (HP:0010975)1.64795629
100Hypoproteinemia (HP:0003075)1.64709679

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.05345901
2PINK13.30292912
3MAP4K23.24968590
4EPHB13.06768935
5TRIM282.89956991
6TNK22.53995834
7MAP4K12.53442510
8FGFR22.29185211
9EIF2AK31.90109360
10MARK31.89308244
11STK161.79788099
12RIPK41.79174027
13DYRK31.68456090
14MAP2K31.63264394
15BCKDK1.61049515
16ERN11.58791513
17EIF2AK11.47314901
18IRAK41.41803815
19RAF11.41427496
20NME21.41108617
21FGFR31.36779013
22BRAF1.35930881
23BTK1.34552188
24NLK1.26651612
25TYK21.19768135
26ZAP701.15399584
27SMG11.15155679
28ZAK1.11205598
29PDK21.10858181
30BLK1.07361154
31CCNB11.06011944
32TLK11.05720679
33KSR21.05418114
34SYK1.00623402
35MST41.00239518
36CSNK1G30.98769102
37TAOK30.96592774
38MAP3K100.95742833
39WNK40.95719033
40CSNK1A1L0.93802044
41GRK60.93779880
42YES10.90726378
43PKN20.90615083
44KSR10.89533113
45TEC0.89113228
46SIK30.86838644
47NME10.85609787
48ATR0.85524449
49HCK0.85055415
50CDK70.83854721
51NUAK10.81881815
52LYN0.79853441
53CSNK1G10.79260159
54PIK3CG0.79246181
55PRKCI0.78406155
56CSF1R0.77840539
57GRK10.77446327
58IKBKE0.74024278
59ACVR1B0.73161087
60BCR0.72960648
61PTK2B0.70967332
62MAP3K10.70669662
63IKBKB0.70257787
64FGR0.70124318
65PRKCQ0.68776100
66PDK10.68491366
67HIPK20.67057072
68BMPR1B0.65718876
69PBK0.63079229
70BRSK20.62014160
71PDPK10.61919361
72RPS6KB10.60553906
73TBK10.57270827
74VRK20.55953354
75NEK20.55670699
76RPS6KA40.55354569
77FES0.55156516
78CAMKK20.55140190
79TNIK0.54700325
80MAP3K20.54131277
81MAPKAPK20.51443148
82IRAK20.50884073
83BRSK10.50401000
84CDK40.49559092
85VRK10.48664198
86RPS6KB20.47816526
87RET0.47231340
88MELK0.46201217
89PIM20.45036122
90MAP3K30.41320894
91MAP3K80.40817081
92JAK20.40053957
93RPS6KA50.39990953
94MAPK110.39472654
95ATM0.39042326
96DYRK20.37898556
97MKNK10.37354867
98LCK0.37198204
99ITK0.37181404
100CDC42BPA0.36387607

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.69461169
2Base excision repair_Homo sapiens_hsa034102.80014769
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.57565633
4Fanconi anemia pathway_Homo sapiens_hsa034602.51145394
5Primary immunodeficiency_Homo sapiens_hsa053402.44845304
6Homologous recombination_Homo sapiens_hsa034402.34633010
7Non-homologous end-joining_Homo sapiens_hsa034502.25346249
8Sulfur relay system_Homo sapiens_hsa041222.06430884
9Glycosaminoglycan degradation_Homo sapiens_hsa005311.96603783
10Nucleotide excision repair_Homo sapiens_hsa034201.95376582
11DNA replication_Homo sapiens_hsa030301.84577379
12Other glycan degradation_Homo sapiens_hsa005111.80566208
13Maturity onset diabetes of the young_Homo sapiens_hsa049501.79447937
14Peroxisome_Homo sapiens_hsa041461.66058449
15Selenocompound metabolism_Homo sapiens_hsa004501.55845823
16Propanoate metabolism_Homo sapiens_hsa006401.53444065
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52566757
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.48379704
19Acute myeloid leukemia_Homo sapiens_hsa052211.41803571
20Pyrimidine metabolism_Homo sapiens_hsa002401.41504271
21Butanoate metabolism_Homo sapiens_hsa006501.41061600
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.37877269
23RNA degradation_Homo sapiens_hsa030181.36016299
24Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.35207020
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.31965920
26Basal transcription factors_Homo sapiens_hsa030221.30371086
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.29086309
28mTOR signaling pathway_Homo sapiens_hsa041501.28749740
29Folate biosynthesis_Homo sapiens_hsa007901.26108664
30Non-small cell lung cancer_Homo sapiens_hsa052231.25058582
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.22175105
32Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.20270325
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.18808686
34N-Glycan biosynthesis_Homo sapiens_hsa005101.16261810
35RNA polymerase_Homo sapiens_hsa030201.09593936
36One carbon pool by folate_Homo sapiens_hsa006701.05421984
37Glutathione metabolism_Homo sapiens_hsa004801.02680372
38Purine metabolism_Homo sapiens_hsa002301.02455423
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.00965627
40Spliceosome_Homo sapiens_hsa030400.97769536
41Regulation of autophagy_Homo sapiens_hsa041400.97416448
42Endometrial cancer_Homo sapiens_hsa052130.95846831
43RNA transport_Homo sapiens_hsa030130.95019143
44Measles_Homo sapiens_hsa051620.93480193
45Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.93118955
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.91033266
47B cell receptor signaling pathway_Homo sapiens_hsa046620.89723006
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.86926913
49Drug metabolism - other enzymes_Homo sapiens_hsa009830.86682109
50Ether lipid metabolism_Homo sapiens_hsa005650.85046314
51Glycerophospholipid metabolism_Homo sapiens_hsa005640.84965045
52Mismatch repair_Homo sapiens_hsa034300.84841493
53Fructose and mannose metabolism_Homo sapiens_hsa000510.84621674
54p53 signaling pathway_Homo sapiens_hsa041150.83787916
55Metabolic pathways_Homo sapiens_hsa011000.82443171
56Fatty acid metabolism_Homo sapiens_hsa012120.82232831
57Complement and coagulation cascades_Homo sapiens_hsa046100.81962636
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79433558
59Herpes simplex infection_Homo sapiens_hsa051680.77248740
60Inositol phosphate metabolism_Homo sapiens_hsa005620.75907080
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75246989
62Osteoclast differentiation_Homo sapiens_hsa043800.74044353
63Hepatitis B_Homo sapiens_hsa051610.72924352
64RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.72185873
65Legionellosis_Homo sapiens_hsa051340.71189760
66Pentose phosphate pathway_Homo sapiens_hsa000300.70992208
67Fatty acid elongation_Homo sapiens_hsa000620.70335740
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68324475
69Chemical carcinogenesis_Homo sapiens_hsa052040.66306716
70Viral carcinogenesis_Homo sapiens_hsa052030.65235494
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64617747
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.64054823
73mRNA surveillance pathway_Homo sapiens_hsa030150.63943180
74Thyroid cancer_Homo sapiens_hsa052160.63172262
75Olfactory transduction_Homo sapiens_hsa047400.60103715
76FoxO signaling pathway_Homo sapiens_hsa040680.59428894
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.58227213
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57929567
79Nitrogen metabolism_Homo sapiens_hsa009100.57201931
80Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56990198
81Fatty acid degradation_Homo sapiens_hsa000710.55555797
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.54100021
83Retinol metabolism_Homo sapiens_hsa008300.52370486
84Arachidonic acid metabolism_Homo sapiens_hsa005900.51342657
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51150163
86Vitamin digestion and absorption_Homo sapiens_hsa049770.50869644
87Insulin resistance_Homo sapiens_hsa049310.50652908
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49743634
89Protein export_Homo sapiens_hsa030600.49477531
90Ribosome_Homo sapiens_hsa030100.47716496
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46961557
92Linoleic acid metabolism_Homo sapiens_hsa005910.46581026
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46460847
94Hepatitis C_Homo sapiens_hsa051600.45624181
95Carbon metabolism_Homo sapiens_hsa012000.45509304
96Pyruvate metabolism_Homo sapiens_hsa006200.45090807
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43001992
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42307086
99Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.40435578
100T cell receptor signaling pathway_Homo sapiens_hsa046600.39182826

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