C14ORF80

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)5.21789487
2GDP-mannose metabolic process (GO:0019673)4.11299884
3UTP biosynthetic process (GO:0006228)4.09506226
4maturation of SSU-rRNA (GO:0030490)4.03809716
5mitotic chromosome condensation (GO:0007076)3.96784582
6DNA unwinding involved in DNA replication (GO:0006268)3.94248193
7DNA replication initiation (GO:0006270)3.84242642
8viral transcription (GO:0019083)3.78686362
9peptidyl-arginine omega-N-methylation (GO:0035247)3.76943405
10tRNA methylation (GO:0030488)3.76101241
11DNA strand elongation involved in DNA replication (GO:0006271)3.75601569
12folic acid metabolic process (GO:0046655)3.75498211
13DNA strand elongation (GO:0022616)3.73459979
14pseudouridine synthesis (GO:0001522)3.72305870
15regulation of mammary gland epithelial cell proliferation (GO:0033599)3.70130542
16negative regulation of DNA-templated transcription, elongation (GO:0032785)3.67307194
17negative regulation of cell size (GO:0045792)3.67223686
18regulation of chromatin binding (GO:0035561)3.61987684
19mitotic sister chromatid segregation (GO:0000070)3.61553794
20GTP biosynthetic process (GO:0006183)3.57014776
21pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.56695591
22tRNA modification (GO:0006400)3.54753128
23pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.53009369
24UTP metabolic process (GO:0046051)3.50757945
25guanosine-containing compound biosynthetic process (GO:1901070)3.46704187
26ncRNA 3-end processing (GO:0043628)3.45160829
27spliceosomal tri-snRNP complex assembly (GO:0000244)3.44701386
28translational termination (GO:0006415)3.43188858
29ribonucleoprotein complex biogenesis (GO:0022613)3.35934199
30ribosome biogenesis (GO:0042254)3.35277469
31viral mRNA export from host cell nucleus (GO:0046784)3.35203192
32regulation of translational fidelity (GO:0006450)3.33310061
33translational elongation (GO:0006414)3.33255775
34telomere maintenance via semi-conservative replication (GO:0032201)3.32987514
35proline biosynthetic process (GO:0006561)3.31154981
36apoptotic process involved in morphogenesis (GO:0060561)3.29639872
37DNA replication checkpoint (GO:0000076)3.28341586
38pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.24429599
39rRNA transcription (GO:0009303)3.23629550
40folic acid-containing compound biosynthetic process (GO:0009396)3.18818155
41deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.16759303
42CTP metabolic process (GO:0046036)3.16536295
43CTP biosynthetic process (GO:0006241)3.16536295
44pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.16186891
45negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.15302631
46pentose metabolic process (GO:0019321)3.15159048
47heterochromatin organization (GO:0070828)3.14818776
48pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.13912616
49snRNA metabolic process (GO:0016073)3.13742479
50regulation of translational termination (GO:0006449)3.12846879
51positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.08679083
52mitotic nuclear envelope reassembly (GO:0007084)3.06647850
53nuclear envelope reassembly (GO:0031468)3.06647850
54nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.06311159
55negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.04559585
56protein insertion into membrane (GO:0051205)3.02383243
57histone arginine methylation (GO:0034969)3.02304463
58transcription from mitochondrial promoter (GO:0006390)3.01373520
59mitochondrial RNA metabolic process (GO:0000959)3.00125463
60activation of Rac GTPase activity (GO:0032863)3.00047636
61negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.95076281
62sister chromatid segregation (GO:0000819)2.92060656
63viral life cycle (GO:0019058)2.91795153
64chromosome condensation (GO:0030261)2.89542779
65rRNA processing (GO:0006364)2.87424829
66peptidyl-arginine methylation (GO:0018216)2.84725739
67peptidyl-arginine N-methylation (GO:0035246)2.84725739
68chromatin assembly (GO:0031497)2.83756225
69positive regulation of T cell apoptotic process (GO:0070234)2.79884652
70cellular protein complex disassembly (GO:0043624)2.77461167
71modulation by virus of host process (GO:0019054)2.76646552
72positive regulation of histone deacetylation (GO:0031065)2.73771819
73rRNA metabolic process (GO:0016072)2.73594957
74positive regulation of lymphocyte apoptotic process (GO:0070230)2.72739138
75negative regulation of viral release from host cell (GO:1902187)2.71676430
76ribosomal small subunit assembly (GO:0000028)2.71060378
77base-excision repair, AP site formation (GO:0006285)2.70903089
78protein complex disassembly (GO:0043241)2.69306630
79intracellular estrogen receptor signaling pathway (GO:0030520)2.66967303
80regulation of mitochondrial translation (GO:0070129)2.65479861
81telomere maintenance via recombination (GO:0000722)2.65261545
82SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.65235747
83nucleotide salvage (GO:0043173)2.64169584
84formation of translation preinitiation complex (GO:0001731)2.62751290
85positive regulation of keratinocyte differentiation (GO:0045618)2.61121403
86protein targeting to ER (GO:0045047)2.60925661
87pyrimidine nucleoside salvage (GO:0043097)2.59675551
88pyrimidine-containing compound salvage (GO:0008655)2.59675551
89regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.58694127
90protein K6-linked ubiquitination (GO:0085020)2.57327988
91positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.57065494
92cellular component biogenesis (GO:0044085)2.56897842
93negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.56881553
94positive regulation of histone acetylation (GO:0035066)2.55841388
95mitotic G1/S transition checkpoint (GO:0044819)2.55659901
96cotranslational protein targeting to membrane (GO:0006613)2.54627907
97ncRNA processing (GO:0034470)2.53965083
98regulation of apoptotic process involved in morphogenesis (GO:1902337)2.53815590
99snRNA processing (GO:0016180)2.53300856
100NIK/NF-kappaB signaling (GO:0038061)2.52713742

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.76372753
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.12292361
3* VDR_21846776_ChIP-Seq_THP-1_Human3.03638551
4FOXM1_23109430_ChIP-Seq_U2OS_Human2.82125440
5MYC_22102868_ChIP-Seq_BL_Human2.80555994
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.69646695
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.45192848
8TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.42556214
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.34724623
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.32062747
11LXR_22292898_ChIP-Seq_THP-1_Human2.25971104
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.18462291
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.10164177
14DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.08443120
15XRN2_22483619_ChIP-Seq_HELA_Human2.05871834
16P68_20966046_ChIP-Seq_HELA_Human1.85067377
17* RACK7_27058665_Chip-Seq_MCF-7_Human1.84022147
18TET1_21451524_ChIP-Seq_MESCs_Mouse1.79937766
19* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.78901596
20* ELK3_25401928_ChIP-Seq_HUVEC_Human1.76926438
21THAP11_20581084_ChIP-Seq_MESCs_Mouse1.74726530
22ETS1_20019798_ChIP-Seq_JURKAT_Human1.73757162
23MYC_19030024_ChIP-ChIP_MESCs_Mouse1.66597852
24CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.62482869
25* GABP_19822575_ChIP-Seq_HepG2_Human1.62402209
26ZNF263_19887448_ChIP-Seq_K562_Human1.60635590
27DCP1A_22483619_ChIP-Seq_HELA_Human1.59242461
28* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.58542098
29MYC_19079543_ChIP-ChIP_MESCs_Mouse1.56775575
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.53932755
31CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.53197604
32NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.51093343
33PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.50835972
34* KDM5A_27292631_Chip-Seq_BREAST_Human1.49348459
35MAF_26560356_Chip-Seq_TH2_Human1.42433728
36* KDM2B_26808549_Chip-Seq_DND41_Human1.42309778
37CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.41632689
38CIITA_25753668_ChIP-Seq_RAJI_Human1.39524011
39BCOR_27268052_Chip-Seq_Bcells_Human1.39340914
40TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.39313894
41ELF1_20517297_ChIP-Seq_JURKAT_Human1.39113646
42CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.38407227
43NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.38358546
44ELF1_17652178_ChIP-ChIP_JURKAT_Human1.36157787
45BCL6_27268052_Chip-Seq_Bcells_Human1.35415581
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.35226721
47SRY_22984422_ChIP-ChIP_TESTIS_Rat1.33057017
48NELFA_20434984_ChIP-Seq_ESCs_Mouse1.32318995
49TCF7_22412390_ChIP-Seq_EML_Mouse1.32268068
50SA1_27219007_Chip-Seq_ERYTHROID_Human1.31334390
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.31066335
52FOXP1_21924763_ChIP-Seq_HESCs_Human1.30929825
53THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30652198
54MAF_26560356_Chip-Seq_TH1_Human1.29431016
55CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.29271762
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.28326377
57SMC4_20622854_ChIP-Seq_HELA_Human1.27369186
58VDR_24763502_ChIP-Seq_THP-1_Human1.26999281
59SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.26753308
60SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.26397491
61* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.26138165
62TTF2_22483619_ChIP-Seq_HELA_Human1.24794790
63EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24673876
64KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23955449
65TP63_17297297_ChIP-ChIP_HaCaT_Human1.23577824
66CTCF_26484167_Chip-Seq_Bcells_Mouse1.22471500
67ZFX_18555785_ChIP-Seq_MESCs_Mouse1.21656012
68PHF8_20622854_ChIP-Seq_HELA_Human1.21510171
69CTCF_27219007_Chip-Seq_ERYTHROID_Human1.20992850
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.20723740
71SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.19948349
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.19887280
73E2F4_17652178_ChIP-ChIP_JURKAT_Human1.18982925
74E2F1_20622854_ChIP-Seq_HELA_Human1.18309064
75BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.17980106
76E2F1_18555785_ChIP-Seq_MESCs_Mouse1.17207314
77CTCF_18555785_ChIP-Seq_MESCs_Mouse1.16403528
78* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15425078
79FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.14959732
80KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14728850
81POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.14569708
82* UTX_26944678_Chip-Seq_JUKART_Human1.14174582
83KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13637722
84RARG_19884340_ChIP-ChIP_MEFs_Mouse1.12820658
85ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.12500449
86TP53_22127205_ChIP-Seq_IMR90_Human1.12344548
87SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.11139357
88CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.11113480
89* CREB1_26743006_Chip-Seq_LNCaP_Human1.11016464
90RARB_24833708_ChIP-Seq_LIVER_Mouse1.10168320
91PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09182140
92NANOG_18555785_ChIP-Seq_MESCs_Mouse1.07697922
93ATF3_27146783_Chip-Seq_COLON_Human1.07624676
94E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.07421247
95SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07399434
96RARA_24833708_ChIP-Seq_LIVER_Mouse1.07370934
97SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.06370578
98UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.06368734
99STAT6_21828071_ChIP-Seq_BEAS2B_Human1.06332116
100* FOXP3_21729870_ChIP-Seq_TREG_Human1.05923191

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003111_abnormal_nucleus_morphology3.69642433
2MP0003693_abnormal_embryo_hatching3.47106628
3MP0010094_abnormal_chromosome_stability3.13381655
4MP0005076_abnormal_cell_differentiation3.13156389
5MP0003705_abnormal_hypodermis_morpholog3.09824800
6MP0004185_abnormal_adipocyte_glucose2.94105144
7MP0003077_abnormal_cell_cycle2.59664762
8MP0002877_abnormal_melanocyte_morpholog2.50687571
9MP0001873_stomach_inflammation2.43899418
10MP0003786_premature_aging2.19125323
11MP0005058_abnormal_lysosome_morphology2.13104443
12MP0009333_abnormal_splenocyte_physiolog2.01932563
13MP0009278_abnormal_bone_marrow2.00359085
14MP0005451_abnormal_body_composition2.00342029
15MP0004957_abnormal_blastocyst_morpholog1.86715068
16MP0005501_abnormal_skin_physiology1.79906150
17MP0003763_abnormal_thymus_physiology1.78184783
18MP0002249_abnormal_larynx_morphology1.73888751
19MP0004233_abnormal_muscle_weight1.66051701
20MP0000678_abnormal_parathyroid_gland1.65764847
21MP0008260_abnormal_autophagy1.57273119
22MP0008932_abnormal_embryonic_tissue1.56659022
23MP0002396_abnormal_hematopoietic_system1.56483371
24MP0001849_ear_inflammation1.56102325
25MP0003123_paternal_imprinting1.52727905
26MP0001348_abnormal_lacrimal_gland1.52610540
27MP0000490_abnormal_crypts_of1.52359934
28MP0003806_abnormal_nucleotide_metabolis1.47848985
29MP0004381_abnormal_hair_follicle1.46678988
30MP0003453_abnormal_keratinocyte_physiol1.46252095
31MP0003172_abnormal_lysosome_physiology1.45899999
32MP0005670_abnormal_white_adipose1.44361333
33MP0000350_abnormal_cell_proliferation1.37924074
34MP0010307_abnormal_tumor_latency1.36988560
35MP0000003_abnormal_adipose_tissue1.36526792
36MP0000703_abnormal_thymus_morphology1.36324876
37MP0005083_abnormal_biliary_tract1.36153318
38MP0002163_abnormal_gland_morphology1.33040158
39MP0000313_abnormal_cell_death1.32631467
40MP0008058_abnormal_DNA_repair1.32510347
41MP0001730_embryonic_growth_arrest1.31604234
42MP0009379_abnormal_foot_pigmentation1.30713062
43MP0002796_impaired_skin_barrier1.30206219
44MP0002653_abnormal_ependyma_morphology1.29224249
45MP0009840_abnormal_foam_cell1.27642289
46MP0010030_abnormal_orbit_morphology1.26150228
47MP0008007_abnormal_cellular_replicative1.26068445
48MP0005666_abnormal_adipose_tissue1.25959601
49MP0003436_decreased_susceptibility_to1.22443737
50MP0000358_abnormal_cell_content/1.20583888
51MP0002019_abnormal_tumor_incidence1.18185512
52MP0004858_abnormal_nervous_system1.17012901
53MP0000685_abnormal_immune_system1.12433043
54MP0010234_abnormal_vibrissa_follicle1.10437410
55MP0008995_early_reproductive_senescence1.10247066
56MP0002089_abnormal_postnatal_growth/wei1.09022518
57MP0006035_abnormal_mitochondrial_morpho1.08715837
58MP0002080_prenatal_lethality1.07531315
59MP0000537_abnormal_urethra_morphology1.06905432
60MP0004947_skin_inflammation1.06766938
61MP0001919_abnormal_reproductive_system1.06645226
62MP0002398_abnormal_bone_marrow1.06355848
63MP0004808_abnormal_hematopoietic_stem1.06112053
64MP0001346_abnormal_lacrimal_gland1.05863918
65MP0005375_adipose_tissue_phenotype1.04712928
66MP0000681_abnormal_thyroid_gland1.03748078
67MP0000858_altered_metastatic_potential1.02788113
68MP0002970_abnormal_white_adipose1.02218950
69MP0002098_abnormal_vibrissa_morphology1.01448860
70MP0002429_abnormal_blood_cell0.97454066
71MP0002722_abnormal_immune_system0.92709565
72MP0001727_abnormal_embryo_implantation0.91756791
73MP0001216_abnormal_epidermal_layer0.89469870
74MP0000733_abnormal_muscle_development0.89381325
75MP0001661_extended_life_span0.88272581
76MP0001697_abnormal_embryo_size0.86590777
77MP0000716_abnormal_immune_system0.85024645
78MP0000470_abnormal_stomach_morphology0.83895906
79MP0005380_embryogenesis_phenotype0.83070069
80MP0001672_abnormal_embryogenesis/_devel0.83070069
81MP0009931_abnormal_skin_appearance0.82708678
82MP0005310_abnormal_salivary_gland0.82455422
83MP0001800_abnormal_humoral_immune0.82241153
84MP0001819_abnormal_immune_cell0.81066682
85MP0002420_abnormal_adaptive_immunity0.79978964
86MP0001270_distended_abdomen0.79629449
87MP0008057_abnormal_DNA_replication0.79420782
88MP0002075_abnormal_coat/hair_pigmentati0.79221586
89MP0009672_abnormal_birth_weight0.76881975
90MP0002723_abnormal_immune_serum0.76416153
91MP0003183_abnormal_peptide_metabolism0.76072968
92MP0006036_abnormal_mitochondrial_physio0.75463794
93MP0002452_abnormal_antigen_presenting0.74409679
94MP0000750_abnormal_muscle_regeneration0.74267585
95MP0000689_abnormal_spleen_morphology0.74064176
96MP0010771_integument_phenotype0.72105981
97MP0002085_abnormal_embryonic_tissue0.71402266
98MP0001186_pigmentation_phenotype0.71329096
99MP0003984_embryonic_growth_retardation0.70820337
100MP0008961_abnormal_basal_metabolism0.68084392

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.38107666
2Aplasia/Hypoplasia of the sacrum (HP:0008517)4.14198642
3Microretrognathia (HP:0000308)3.72950848
4Breast hypoplasia (HP:0003187)3.71073036
5Abnormal number of erythroid precursors (HP:0012131)3.59799284
6Broad distal phalanx of finger (HP:0009836)3.58887499
7Hyperacusis (HP:0010780)3.54283915
8Abnormality of cells of the erythroid lineage (HP:0012130)3.51186123
9Testicular atrophy (HP:0000029)3.49202588
10Chromosomal breakage induced by crosslinking agents (HP:0003221)3.36881630
11Aplasia/Hypoplasia of the patella (HP:0006498)3.34748626
12Increased neuronal autofluorescent lipopigment (HP:0002074)3.18528705
13Patellar aplasia (HP:0006443)3.16977899
14Squamous cell carcinoma (HP:0002860)3.13427594
15Reticulocytopenia (HP:0001896)3.07956469
16Progressive muscle weakness (HP:0003323)2.92547414
17Chromsome breakage (HP:0040012)2.80100372
18Increased cerebral lipofuscin (HP:0011813)2.76354797
19Stridor (HP:0010307)2.61714521
20Microvesicular hepatic steatosis (HP:0001414)2.60481857
21Absent thumb (HP:0009777)2.57375706
22Ragged-red muscle fibers (HP:0003200)2.52772833
23Broad face (HP:0000283)2.51998405
24Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.51518244
25Short thumb (HP:0009778)2.47660166
26Ulnar bowing (HP:0003031)2.40230713
27Deep palmar crease (HP:0006191)2.37390106
28Self-mutilation (HP:0000742)2.34724351
29Ureteral duplication (HP:0000073)2.34259950
30Slender long bone (HP:0003100)2.28306932
31Abnormality of the thoracic spine (HP:0100711)2.27428488
32Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.24096935
33Septate vagina (HP:0001153)2.22178794
34Thin bony cortex (HP:0002753)2.19671010
35Long palpebral fissure (HP:0000637)2.18699865
36Thoracic kyphosis (HP:0002942)2.13501432
37Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.13009799
38Poikiloderma (HP:0001029)2.10569412
39J-shaped sella turcica (HP:0002680)2.10369246
40Rough bone trabeculation (HP:0100670)2.08953150
41Rectal prolapse (HP:0002035)2.08689241
42Pallor (HP:0000980)2.07849909
43Hypoplasia of the capital femoral epiphysis (HP:0003090)2.06613688
44Optic nerve coloboma (HP:0000588)2.05546883
45Horseshoe kidney (HP:0000085)2.05076836
46Selective tooth agenesis (HP:0001592)2.02841362
47Abnormality of the preputium (HP:0100587)2.00286844
48Abnormality of DNA repair (HP:0003254)1.99766083
49Hypertensive crisis (HP:0100735)1.98870109
50Abnormal number of incisors (HP:0011064)1.97511603
51Abnormality of reticulocytes (HP:0004312)1.97422954
52Insomnia (HP:0100785)1.95583406
53Hypergonadotropic hypogonadism (HP:0000815)1.90249804
54Duplicated collecting system (HP:0000081)1.89367080
55Abnormality of the distal phalanges of the toes (HP:0010182)1.89360180
56Bowing of the arm (HP:0006488)1.88516487
57Bowed forearm bones (HP:0003956)1.88516487
58Facial hemangioma (HP:0000329)1.88127735
59Abnormality of the carotid arteries (HP:0005344)1.88111401
60Flattened epiphyses (HP:0003071)1.85570322
61Myopathic facies (HP:0002058)1.84611844
62Abnormality of cochlea (HP:0000375)1.84129453
63Progressive microcephaly (HP:0000253)1.83759174
64Abnormal trabecular bone morphology (HP:0100671)1.80105290
65Visual hallucinations (HP:0002367)1.79692154
66Abnormality of lateral ventricle (HP:0030047)1.78951056
67Hyperthyroidism (HP:0000836)1.78882835
6811 pairs of ribs (HP:0000878)1.78753658
69Hypoparathyroidism (HP:0000829)1.78691568
70Down-sloping shoulders (HP:0200021)1.77153606
71Elfin facies (HP:0004428)1.77068504
72Increased serum ferritin (HP:0003281)1.76819805
73Abnormality of the renal collecting system (HP:0004742)1.75927211
74Atresia of the external auditory canal (HP:0000413)1.75776654
75Colitis (HP:0002583)1.74876138
76Rib fusion (HP:0000902)1.72971364
77Trismus (HP:0000211)1.70758212
78Achilles tendon contracture (HP:0001771)1.69602518
79Cleft eyelid (HP:0000625)1.67998158
80Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.67458097
81Absent epiphyses (HP:0010577)1.67458097
82Bone marrow hypocellularity (HP:0005528)1.67165238
83Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.65821277
84Abnormality of the umbilical cord (HP:0010881)1.64846863
85Flat capital femoral epiphysis (HP:0003370)1.63747180
86Short femoral neck (HP:0100864)1.63727547
87Abnormality of the columella (HP:0009929)1.63630400
88Intestinal fistula (HP:0100819)1.63507719
89Patellar dislocation (HP:0002999)1.61654545
90Entropion (HP:0000621)1.60381701
91Short nail (HP:0001799)1.58936529
92Duplication of thumb phalanx (HP:0009942)1.58859732
93Cortical visual impairment (HP:0100704)1.57882890
94Abnormality of the fingertips (HP:0001211)1.56678952
95Concave nail (HP:0001598)1.56601562
96Overriding aorta (HP:0002623)1.56498201
97Abnormality of homocysteine metabolism (HP:0010919)1.56346178
98Homocystinuria (HP:0002156)1.56346178
99Hypoplasia of the pons (HP:0012110)1.55677292
100Diaphragmatic weakness (HP:0009113)1.55629512

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.43122662
2SMG13.97818150
3NME23.81498694
4IRAK33.22427128
5SIK13.08856548
6ICK2.64856132
7EPHA22.49358900
8TLK12.39905700
9BUB12.36479524
10EEF2K2.31222516
11VRK22.17403350
12MAP3K111.96918611
13PKN21.94495944
14MAP4K11.77607419
15RPS6KB21.76487932
16ERN11.72756064
17MAP2K31.67650231
18TESK21.63217389
19IRAK41.51822848
20CDK121.48885831
21SIK21.48495522
22NME11.44383619
23PRPF4B1.42241974
24AURKA1.35336856
25MAP2K21.30327895
26STK161.27294578
27MAP3K101.23767797
28PIM21.23315696
29MAPK111.19265604
30CDK81.18446636
31MAPKAPK31.17797475
32IRAK21.16499222
33CDC71.15975251
34CDK41.15047348
35CDK71.14601630
36MST1R1.12561033
37GRK61.06966334
38CHEK21.05496972
39PRKD21.02858660
40PRKCI1.01446540
41CAMK1D0.93652552
42IKBKB0.91563013
43PTK60.89766362
44MTOR0.89061670
45CAMKK10.88526716
46SIK30.88394519
47TBK10.87412154
48ZAK0.84913152
49NEK20.83121554
50RPS6KC10.82728929
51RPS6KL10.82728929
52RPS6KA20.82575018
53RPS6KA60.81936833
54TAOK20.80877550
55BRAF0.80184212
56PAK40.77607062
57ARAF0.77065919
58MAPK150.74782457
59MAP3K80.73637844
60CHUK0.71139805
61ATR0.71086782
62PDPK10.70938642
63BCKDK0.69537213
64TAF10.68516636
65MAP2K60.67588545
66TNK20.67404079
67MAP3K130.65297637
68AURKB0.64794626
69MAP3K30.63021912
70PRKD30.62825880
71BRSK10.62349324
72CHEK10.60179608
73TAOK10.58050219
74TTN0.57261150
75CDK90.56463924
76ILK0.55588549
77RPS6KA10.55363208
78STK40.54042063
79HIPK20.52254667
80STK100.50041615
81MARK20.49098307
82PLK10.47098334
83TESK10.45385857
84RPS6KA50.44742887
85DAPK10.42989786
86MUSK0.42707279
87MAPKAPK20.38597474
88DAPK30.38319979
89MELK0.37374712
90VRK10.37287933
91BTK0.36777799
92AKT20.36716858
93CDK20.36403820
94CDC42BPA0.36138910
95SRPK10.35689481
96MAP3K10.34375405
97CCNB10.33726246
98KDR0.33261792
99CDK10.32124658
100IRAK10.31358603

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041224.60376760
2DNA replication_Homo sapiens_hsa030304.50551493
3Base excision repair_Homo sapiens_hsa034103.48735044
4Ribosome_Homo sapiens_hsa030103.39245425
5Pyrimidine metabolism_Homo sapiens_hsa002402.42759526
6Homologous recombination_Homo sapiens_hsa034402.42177135
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.22151173
8Spliceosome_Homo sapiens_hsa030402.08297224
9Bladder cancer_Homo sapiens_hsa052192.01981015
10Fanconi anemia pathway_Homo sapiens_hsa034601.92590207
11Other glycan degradation_Homo sapiens_hsa005111.91674887
12Fructose and mannose metabolism_Homo sapiens_hsa000511.90950973
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.88254249
14One carbon pool by folate_Homo sapiens_hsa006701.87607222
15RNA polymerase_Homo sapiens_hsa030201.86845344
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.77696955
17Nucleotide excision repair_Homo sapiens_hsa034201.70809154
18Cell cycle_Homo sapiens_hsa041101.64426406
19Mismatch repair_Homo sapiens_hsa034301.58120432
20Notch signaling pathway_Homo sapiens_hsa043301.56781637
21Vitamin B6 metabolism_Homo sapiens_hsa007501.48062404
22Acute myeloid leukemia_Homo sapiens_hsa052211.40162349
23Pentose phosphate pathway_Homo sapiens_hsa000301.39802066
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.38457971
25RNA transport_Homo sapiens_hsa030131.32935193
26Biosynthesis of amino acids_Homo sapiens_hsa012301.29110395
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.25906190
28Selenocompound metabolism_Homo sapiens_hsa004501.25068194
29Systemic lupus erythematosus_Homo sapiens_hsa053221.22846554
30Galactose metabolism_Homo sapiens_hsa000521.17386327
31Non-small cell lung cancer_Homo sapiens_hsa052231.17255412
32VEGF signaling pathway_Homo sapiens_hsa043701.16968478
33B cell receptor signaling pathway_Homo sapiens_hsa046621.12819422
34Central carbon metabolism in cancer_Homo sapiens_hsa052301.12647720
35Epstein-Barr virus infection_Homo sapiens_hsa051691.12371750
36Primary immunodeficiency_Homo sapiens_hsa053401.12044211
37Viral carcinogenesis_Homo sapiens_hsa052031.09751578
38Folate biosynthesis_Homo sapiens_hsa007901.09390689
39Chronic myeloid leukemia_Homo sapiens_hsa052201.08368199
40mRNA surveillance pathway_Homo sapiens_hsa030151.07778063
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.05397609
42Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.99907794
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.98042229
44Alcoholism_Homo sapiens_hsa050340.89310799
45HTLV-I infection_Homo sapiens_hsa051660.88849529
46Apoptosis_Homo sapiens_hsa042100.85075463
47Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81358946
48Purine metabolism_Homo sapiens_hsa002300.80814683
49Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.80679010
50NF-kappa B signaling pathway_Homo sapiens_hsa040640.76928280
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.76897979
52Herpes simplex infection_Homo sapiens_hsa051680.76763764
53p53 signaling pathway_Homo sapiens_hsa041150.75524236
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.74715729
55mTOR signaling pathway_Homo sapiens_hsa041500.74283425
56Lysine degradation_Homo sapiens_hsa003100.72735737
57Toll-like receptor signaling pathway_Homo sapiens_hsa046200.69601161
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.69126970
59Hepatitis B_Homo sapiens_hsa051610.68199014
60Thyroid cancer_Homo sapiens_hsa052160.66734466
61N-Glycan biosynthesis_Homo sapiens_hsa005100.66434451
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66404892
63Huntingtons disease_Homo sapiens_hsa050160.64510222
64Proteasome_Homo sapiens_hsa030500.62355252
652-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.61969373
66Hepatitis C_Homo sapiens_hsa051600.61380370
67Non-homologous end-joining_Homo sapiens_hsa034500.61193532
68Pancreatic cancer_Homo sapiens_hsa052120.61057333
69Vibrio cholerae infection_Homo sapiens_hsa051100.60040275
70Glycosaminoglycan degradation_Homo sapiens_hsa005310.59473269
71Lysosome_Homo sapiens_hsa041420.59272804
72Basal transcription factors_Homo sapiens_hsa030220.57555083
73Intestinal immune network for IgA production_Homo sapiens_hsa046720.55971088
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55832898
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.55097800
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54004776
77TNF signaling pathway_Homo sapiens_hsa046680.52983122
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.49955352
79Oxidative phosphorylation_Homo sapiens_hsa001900.47392660
80Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47292266
81T cell receptor signaling pathway_Homo sapiens_hsa046600.46221727
82AMPK signaling pathway_Homo sapiens_hsa041520.45626416
83Small cell lung cancer_Homo sapiens_hsa052220.43191419
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42781512
85Influenza A_Homo sapiens_hsa051640.40863630
86RNA degradation_Homo sapiens_hsa030180.40849378
87Carbon metabolism_Homo sapiens_hsa012000.40534363
88Endometrial cancer_Homo sapiens_hsa052130.40375978
89Osteoclast differentiation_Homo sapiens_hsa043800.39429896
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38475074
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37310807
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36599158
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35454606
94MicroRNAs in cancer_Homo sapiens_hsa052060.34908603
95Glutathione metabolism_Homo sapiens_hsa004800.34124530
96Shigellosis_Homo sapiens_hsa051310.33238738
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.32643783
98Basal cell carcinoma_Homo sapiens_hsa052170.31427698
99Sphingolipid metabolism_Homo sapiens_hsa006000.29933185
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.28043231

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