C14ORF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)8.96280089
2ATP synthesis coupled proton transport (GO:0015986)7.84134628
3energy coupled proton transport, down electrochemical gradient (GO:0015985)7.84134628
4viral transcription (GO:0019083)7.13698022
5translational termination (GO:0006415)6.92609953
6mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.72609000
7respiratory electron transport chain (GO:0022904)6.50936406
8electron transport chain (GO:0022900)6.39464947
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.21701601
10cotranslational protein targeting to membrane (GO:0006613)6.17970350
11ribosomal small subunit assembly (GO:0000028)6.13345136
12protein targeting to ER (GO:0045047)6.12205667
13establishment of protein localization to mitochondrial membrane (GO:0090151)5.93922646
14establishment of protein localization to endoplasmic reticulum (GO:0072599)5.88410919
15protein localization to endoplasmic reticulum (GO:0070972)5.77185310
16translational elongation (GO:0006414)5.75802774
17chaperone-mediated protein transport (GO:0072321)5.62434396
18protein complex biogenesis (GO:0070271)5.49890952
19ribosomal small subunit biogenesis (GO:0042274)5.36885751
20cellular protein complex disassembly (GO:0043624)5.33376761
21viral life cycle (GO:0019058)5.25649622
22mitochondrial respiratory chain complex assembly (GO:0033108)5.13817668
23mitochondrial respiratory chain complex I assembly (GO:0032981)5.11164918
24NADH dehydrogenase complex assembly (GO:0010257)5.11164918
25mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.11164918
26maturation of SSU-rRNA (GO:0030490)5.10501939
27nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.10018622
28translational initiation (GO:0006413)4.87956854
29protein neddylation (GO:0045116)4.73693104
30ribosomal large subunit biogenesis (GO:0042273)4.61106178
31hydrogen ion transmembrane transport (GO:1902600)4.47592152
32protein complex disassembly (GO:0043241)4.47122686
33ATP biosynthetic process (GO:0006754)4.43167878
34macromolecular complex disassembly (GO:0032984)4.29504112
35translation (GO:0006412)4.24047195
36proteasome assembly (GO:0043248)4.13385585
37protein targeting to membrane (GO:0006612)4.07509558
38purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.06966498
39purine nucleoside triphosphate biosynthetic process (GO:0009145)4.06186322
40regulation of mitochondrial translation (GO:0070129)4.03964751
41proton transport (GO:0015992)3.98232654
42hydrogen transport (GO:0006818)3.90220614
43inner mitochondrial membrane organization (GO:0007007)3.87477786
44sequestering of actin monomers (GO:0042989)3.84444728
45nuclear-transcribed mRNA catabolic process (GO:0000956)3.72294304
46transcription elongation from RNA polymerase III promoter (GO:0006385)3.72055128
47termination of RNA polymerase III transcription (GO:0006386)3.72055128
48respiratory chain complex IV assembly (GO:0008535)3.71717367
49oxidative phosphorylation (GO:0006119)3.70919986
50cytochrome complex assembly (GO:0017004)3.69629620
51ribonucleoside triphosphate biosynthetic process (GO:0009201)3.54073193
52mRNA catabolic process (GO:0006402)3.51120473
53negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.43072691
54nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.42821728
55cellular component biogenesis (GO:0044085)3.39305936
56intracellular protein transmembrane import (GO:0044743)3.32700324
57exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.30196405
58protein targeting to mitochondrion (GO:0006626)3.24957429
59protein-cofactor linkage (GO:0018065)3.23425882
60establishment of protein localization to mitochondrion (GO:0072655)3.22195280
61nucleoside triphosphate biosynthetic process (GO:0009142)3.18972902
62positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.18743851
63protein localization to mitochondrion (GO:0070585)3.16498935
64RNA catabolic process (GO:0006401)3.16444132
65behavioral response to nicotine (GO:0035095)3.14435343
66mitochondrial transport (GO:0006839)3.09223646
67regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.08150097
68negative regulation of ligase activity (GO:0051352)3.07388236
69negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.07388236
70tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.06766550
71RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.06766550
72regulation of cellular amino acid metabolic process (GO:0006521)3.03012951
73purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.98955300
74purine nucleoside monophosphate biosynthetic process (GO:0009127)2.98955300
75aerobic respiration (GO:0009060)2.97811242
76DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.95938735
77anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.94553273
78spliceosomal snRNP assembly (GO:0000387)2.93830018
79DNA damage response, detection of DNA damage (GO:0042769)2.93429268
80rRNA modification (GO:0000154)2.92986601
81GTP biosynthetic process (GO:0006183)2.92328792
82establishment of protein localization to membrane (GO:0090150)2.90192815
83protein targeting (GO:0006605)2.89573128
84signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.88907244
85signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.88907244
86signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.88907244
87intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.85765183
88signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.85765183
89spliceosomal complex assembly (GO:0000245)2.85246612
90ribonucleoprotein complex biogenesis (GO:0022613)2.83626455
91water-soluble vitamin biosynthetic process (GO:0042364)2.83543622
92pseudouridine synthesis (GO:0001522)2.76980067
93signal transduction involved in DNA integrity checkpoint (GO:0072401)2.76186337
94signal transduction involved in DNA damage checkpoint (GO:0072422)2.76186337
95signal transduction involved in cell cycle checkpoint (GO:0072395)2.74364102
96positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.74253527
97chromatin remodeling at centromere (GO:0031055)2.71796681
98establishment of protein localization to organelle (GO:0072594)2.70246214
99rRNA processing (GO:0006364)2.67779029
100pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.67522988

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.77128129
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.68612360
3EST1_17652178_ChIP-ChIP_JURKAT_Human4.51808448
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.93273097
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.43996897
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.21968520
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.18219884
8* ETS1_20019798_ChIP-Seq_JURKAT_Human3.17012105
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.09371509
10MYC_18555785_ChIP-Seq_MESCs_Mouse3.01314591
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.87876955
12ELK1_19687146_ChIP-ChIP_HELA_Human2.60381537
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.57448885
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.53457513
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.38068074
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.37059989
17EZH2_22144423_ChIP-Seq_EOC_Human2.34185680
18* VDR_23849224_ChIP-Seq_CD4+_Human2.33497666
19PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.16696584
20THAP11_20581084_ChIP-Seq_MESCs_Mouse2.11117731
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.03202438
22TTF2_22483619_ChIP-Seq_HELA_Human2.02147820
23SRF_21415370_ChIP-Seq_HL-1_Mouse1.99080959
24FOXP3_21729870_ChIP-Seq_TREG_Human1.97732453
25MYC_18940864_ChIP-ChIP_HL60_Human1.96364041
26VDR_22108803_ChIP-Seq_LS180_Human1.95955497
27E2F4_17652178_ChIP-ChIP_JURKAT_Human1.86361922
28MYC_19079543_ChIP-ChIP_MESCs_Mouse1.84802115
29XRN2_22483619_ChIP-Seq_HELA_Human1.83847141
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.79903711
31ZNF274_21170338_ChIP-Seq_K562_Hela1.79693198
32MYC_19030024_ChIP-ChIP_MESCs_Mouse1.69832072
33FUS_26573619_Chip-Seq_HEK293_Human1.69553821
34YY1_21170310_ChIP-Seq_MESCs_Mouse1.60401660
35ELF1_17652178_ChIP-ChIP_JURKAT_Human1.59157925
36EWS_26573619_Chip-Seq_HEK293_Human1.58075013
37EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.56599787
38E2F1_18555785_ChIP-Seq_MESCs_Mouse1.56356283
39* DCP1A_22483619_ChIP-Seq_HELA_Human1.56296148
40ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.50843858
41POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.44039313
42PADI4_21655091_ChIP-ChIP_MCF-7_Human1.42912939
43CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.42681818
44FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.39131134
45ELK1_22589737_ChIP-Seq_MCF10A_Human1.37248234
46* GABP_19822575_ChIP-Seq_HepG2_Human1.36907375
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.32437009
48TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.30528106
49TAF15_26573619_Chip-Seq_HEK293_Human1.27915427
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.26511709
51BMI1_23680149_ChIP-Seq_NPCS_Mouse1.25886660
52FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.24885288
53TP53_22573176_ChIP-Seq_HFKS_Human1.24050736
54* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22217877
55POU5F1_16153702_ChIP-ChIP_HESCs_Human1.20015784
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18569818
57IGF1R_20145208_ChIP-Seq_DFB_Human1.17346906
58SOX2_16153702_ChIP-ChIP_HESCs_Human1.17047899
59HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16810681
60* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16271996
61YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16186037
62ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.15971423
63MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.13229179
64NELFA_20434984_ChIP-Seq_ESCs_Mouse1.11797511
65ZFP57_27257070_Chip-Seq_ESCs_Mouse1.11748437
66FLI1_27457419_Chip-Seq_LIVER_Mouse1.10003378
67HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.09749759
68CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08506668
69EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07270642
70PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05343808
71ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.03324817
72P300_19829295_ChIP-Seq_ESCs_Human1.03080414
73POU3F2_20337985_ChIP-ChIP_501MEL_Human1.02545137
74GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01121301
75CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.00794310
76FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00507934
77IRF1_19129219_ChIP-ChIP_H3396_Human1.00469648
78SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.98651985
79RBPJ_22232070_ChIP-Seq_NCS_Mouse0.97033596
80NANOG_16153702_ChIP-ChIP_HESCs_Human0.96993098
81POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.96792710
82HTT_18923047_ChIP-ChIP_STHdh_Human0.96011171
83RNF2_27304074_Chip-Seq_NSC_Mouse0.93371192
84ERG_20517297_ChIP-Seq_VCAP_Human0.91244720
85GBX2_23144817_ChIP-Seq_PC3_Human0.90259177
86GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.89716769
87FOXA1_27270436_Chip-Seq_PROSTATE_Human0.88688931
88FOXA1_25329375_ChIP-Seq_VCAP_Human0.88688931
89TP63_19390658_ChIP-ChIP_HaCaT_Human0.88462445
90CTCF_18555785_ChIP-Seq_MESCs_Mouse0.85099913
91CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.84798651
92SOX2_19829295_ChIP-Seq_ESCs_Human0.80323046
93NANOG_19829295_ChIP-Seq_ESCs_Human0.80323046
94NCOR_22424771_ChIP-Seq_293T_Human0.79911504
95* AR_20517297_ChIP-Seq_VCAP_Human0.79745138
96KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.78140966
97PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.77721589
98SOX2_18555785_ChIP-Seq_MESCs_Mouse0.76806391
99ETV2_25802403_ChIP-Seq_MESCs_Mouse0.76500800
100REST_21632747_ChIP-Seq_MESCs_Mouse0.76073936

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.60152618
2MP0006292_abnormal_olfactory_placode2.91807049
3MP0003136_yellow_coat_color2.62504411
4MP0002938_white_spotting2.30197200
5MP0003806_abnormal_nucleotide_metabolis2.29535994
6MP0003880_abnormal_central_pattern2.29478613
7MP0001529_abnormal_vocalization2.29459088
8MP0002837_dystrophic_cardiac_calcinosis2.22244061
9MP0006072_abnormal_retinal_apoptosis2.02922660
10MP0004142_abnormal_muscle_tone2.02386274
11MP0000372_irregular_coat_pigmentation2.01236314
12MP0003011_delayed_dark_adaptation2.00605009
13MP0002638_abnormal_pupillary_reflex1.97467824
14MP0003186_abnormal_redox_activity1.88242170
15MP0001984_abnormal_olfaction1.80689704
16MP0006036_abnormal_mitochondrial_physio1.80400451
17MP0000566_synostosis1.79975764
18MP0008058_abnormal_DNA_repair1.77484139
19MP0002736_abnormal_nociception_after1.76642814
20MP0009046_muscle_twitch1.75937386
21MP0008789_abnormal_olfactory_epithelium1.73851381
22MP0008877_abnormal_DNA_methylation1.72097772
23MP0003718_maternal_effect1.70911326
24MP0001968_abnormal_touch/_nociception1.67227700
25MP0008995_early_reproductive_senescence1.67029881
26MP0001905_abnormal_dopamine_level1.64963438
27MP0002653_abnormal_ependyma_morphology1.64846133
28MP0005084_abnormal_gallbladder_morpholo1.64271743
29MP0001485_abnormal_pinna_reflex1.63065358
30MP0005551_abnormal_eye_electrophysiolog1.55087544
31MP0006276_abnormal_autonomic_nervous1.54909543
32MP0002272_abnormal_nervous_system1.53836067
33MP0009745_abnormal_behavioral_response1.53661480
34MP0006035_abnormal_mitochondrial_morpho1.46873094
35MP0002277_abnormal_respiratory_mucosa1.44624716
36MP0000631_abnormal_neuroendocrine_gland1.44082259
37MP0002102_abnormal_ear_morphology1.41369044
38MP0002822_catalepsy1.39701358
39MP0003122_maternal_imprinting1.39533867
40MP0001293_anophthalmia1.38711632
41MP0004145_abnormal_muscle_electrophysio1.38071798
42MP0008875_abnormal_xenobiotic_pharmacok1.37855911
43MP0010030_abnormal_orbit_morphology1.36313902
44MP0005394_taste/olfaction_phenotype1.33066823
45MP0005499_abnormal_olfactory_system1.33066823
46MP0005253_abnormal_eye_physiology1.32660990
47MP0003121_genomic_imprinting1.30866067
48MP0004742_abnormal_vestibular_system1.30408739
49MP0004133_heterotaxia1.30217760
50MP0004147_increased_porphyrin_level1.29413576
51MP0002234_abnormal_pharynx_morphology1.25733987
52MP0008872_abnormal_physiological_respon1.21913454
53MP0002064_seizures1.21894392
54MP0002735_abnormal_chemical_nociception1.20316079
55MP0001486_abnormal_startle_reflex1.19996703
56MP0005423_abnormal_somatic_nervous1.17415331
57MP0002734_abnormal_mechanical_nocicepti1.16895865
58MP0003693_abnormal_embryo_hatching1.16094070
59MP0001986_abnormal_taste_sensitivity1.14435225
60MP0003787_abnormal_imprinting1.13440702
61MP0005646_abnormal_pituitary_gland1.10428403
62MP0002572_abnormal_emotion/affect_behav1.08912776
63MP0003938_abnormal_ear_development1.06925995
64MP0002095_abnormal_skin_pigmentation1.04343459
65MP0001970_abnormal_pain_threshold1.04248615
66MP0002557_abnormal_social/conspecific_i1.00348108
67MP0002067_abnormal_sensory_capabilities1.00297226
68MP0004957_abnormal_blastocyst_morpholog1.00277071
69MP0000026_abnormal_inner_ear1.00203008
70MP0005645_abnormal_hypothalamus_physiol1.00145256
71MP0000049_abnormal_middle_ear0.98598793
72MP0000778_abnormal_nervous_system0.96981347
73MP0003646_muscle_fatigue0.96163479
74MP0002160_abnormal_reproductive_system0.94523688
75MP0003315_abnormal_perineum_morphology0.94396833
76MP0004215_abnormal_myocardial_fiber0.93508962
77MP0003123_paternal_imprinting0.89897975
78MP0002752_abnormal_somatic_nervous0.88953170
79MP0004885_abnormal_endolymph0.87989303
80MP0010386_abnormal_urinary_bladder0.87663916
81MP0002751_abnormal_autonomic_nervous0.87442509
82MP0003635_abnormal_synaptic_transmissio0.86791257
83MP0002210_abnormal_sex_determination0.86102882
84MP0003786_premature_aging0.85654302
85MP0005195_abnormal_posterior_eye0.85508182
86MP0005408_hypopigmentation0.85294982
87MP0002733_abnormal_thermal_nociception0.85056019
88MP0009697_abnormal_copulation0.84773497
89MP0005389_reproductive_system_phenotype0.84642266
90MP0003137_abnormal_impulse_conducting0.82805621
91MP0001764_abnormal_homeostasis0.81845899
92MP0001440_abnormal_grooming_behavior0.80277070
93MP0010094_abnormal_chromosome_stability0.79900859
94MP0001188_hyperpigmentation0.77435676
95MP0001963_abnormal_hearing_physiology0.75135960
96MP0002184_abnormal_innervation0.74519245
97MP0003283_abnormal_digestive_organ0.74349539
98MP0003890_abnormal_embryonic-extraembry0.74113656
99MP0002063_abnormal_learning/memory/cond0.73884462
100MP0003567_abnormal_fetal_cardiomyocyte0.73851407

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.13968941
2Abnormal mitochondria in muscle tissue (HP:0008316)5.60631362
3Mitochondrial inheritance (HP:0001427)5.57820066
4Acute encephalopathy (HP:0006846)5.31457082
5Increased hepatocellular lipid droplets (HP:0006565)5.16310287
6Progressive macrocephaly (HP:0004481)5.13939988
7Increased CSF lactate (HP:0002490)4.85053791
8Abnormality of cells of the erythroid lineage (HP:0012130)4.84012717
9Lipid accumulation in hepatocytes (HP:0006561)4.82083799
10Abnormal number of erythroid precursors (HP:0012131)4.70433906
11Hepatocellular necrosis (HP:0001404)4.66869663
12Reticulocytopenia (HP:0001896)4.34462145
13Hepatic necrosis (HP:0002605)4.33459231
14Renal Fanconi syndrome (HP:0001994)4.27424746
15Macrocytic anemia (HP:0001972)4.00861208
16Cerebral edema (HP:0002181)3.87380556
17Increased intramyocellular lipid droplets (HP:0012240)3.81076309
183-Methylglutaconic aciduria (HP:0003535)3.78927150
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.31577076
20Exertional dyspnea (HP:0002875)3.29504115
21Congenital, generalized hypertrichosis (HP:0004540)3.25958317
22Increased muscle lipid content (HP:0009058)3.23831666
23Decreased activity of mitochondrial respiratory chain (HP:0008972)3.23328907
24Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.23328907
25Lactic acidosis (HP:0003128)3.06361657
26Optic disc pallor (HP:0000543)3.04104218
27Respiratory failure (HP:0002878)3.00215218
28Pancreatic cysts (HP:0001737)2.90728093
29Increased serum lactate (HP:0002151)2.88743076
30Pancreatic fibrosis (HP:0100732)2.86582984
31Abnormality of renal resorption (HP:0011038)2.84741197
32Exercise intolerance (HP:0003546)2.84527119
33Pallor (HP:0000980)2.83083527
34Leukodystrophy (HP:0002415)2.81479018
35Myokymia (HP:0002411)2.70092175
36Septo-optic dysplasia (HP:0100842)2.69072892
37Molar tooth sign on MRI (HP:0002419)2.68801000
38Abnormality of midbrain morphology (HP:0002418)2.68801000
39Respiratory difficulties (HP:0002880)2.67808717
40True hermaphroditism (HP:0010459)2.67250564
41Abnormality of urine glucose concentration (HP:0011016)2.55346684
42Glycosuria (HP:0003076)2.55346684
43Medial flaring of the eyebrow (HP:0010747)2.47028819
44Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.46846620
45Lethargy (HP:0001254)2.43006948
46Nephronophthisis (HP:0000090)2.33829319
47Methylmalonic acidemia (HP:0002912)2.23402280
48Hyperglycinemia (HP:0002154)2.21788150
49CNS demyelination (HP:0007305)2.18396814
50X-linked dominant inheritance (HP:0001423)2.17601041
51Hyperphosphaturia (HP:0003109)2.16694747
52Generalized aminoaciduria (HP:0002909)2.15296221
53Sclerocornea (HP:0000647)2.11227743
54Methylmalonic aciduria (HP:0012120)2.07480453
55Colon cancer (HP:0003003)2.07406546
56Gait imbalance (HP:0002141)2.05904572
57Aplastic anemia (HP:0001915)2.03296463
58Congenital primary aphakia (HP:0007707)1.99698702
59Type I transferrin isoform profile (HP:0003642)1.98579219
60Absent septum pellucidum (HP:0001331)1.98082678
61Abnormality of the labia minora (HP:0012880)1.92661131
62Nephrogenic diabetes insipidus (HP:0009806)1.88291822
63Absent thumb (HP:0009777)1.86543764
64Aplasia/Hypoplasia of the sacrum (HP:0008517)1.85098710
65Concave nail (HP:0001598)1.83991436
66Emotional lability (HP:0000712)1.81468829
67Male pseudohermaphroditism (HP:0000037)1.80818993
68Abnormality of the renal medulla (HP:0100957)1.80128717
69Optic nerve hypoplasia (HP:0000609)1.79603341
70Limb dystonia (HP:0002451)1.77336083
71Oral leukoplakia (HP:0002745)1.77184944
72Stenosis of the external auditory canal (HP:0000402)1.75709177
73Focal motor seizures (HP:0011153)1.73715587
74Abnormality of the anterior horn cell (HP:0006802)1.73120882
75Degeneration of anterior horn cells (HP:0002398)1.73120882
76Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.72388955
77Abnormal ciliary motility (HP:0012262)1.71789873
78Hypothermia (HP:0002045)1.70043601
79Congenital stationary night blindness (HP:0007642)1.69486008
80Blindness (HP:0000618)1.69274647
81Genital tract atresia (HP:0001827)1.68286285
82Hyperglycinuria (HP:0003108)1.67343518
83Abnormal respiratory motile cilium physiology (HP:0012261)1.67166537
84Type II lissencephaly (HP:0007260)1.66510137
85Vaginal atresia (HP:0000148)1.66384117
86Abnormality of serum amino acid levels (HP:0003112)1.64741458
87Dicarboxylic aciduria (HP:0003215)1.62282096
88Abnormality of dicarboxylic acid metabolism (HP:0010995)1.62282096
89Triphalangeal thumb (HP:0001199)1.61706660
90Abnormality of the septum pellucidum (HP:0007375)1.60306966
91Depressed nasal ridge (HP:0000457)1.59992738
92Increased serum pyruvate (HP:0003542)1.57046569
93Rib fusion (HP:0000902)1.56815515
94Anencephaly (HP:0002323)1.56369747
95Aplasia/hypoplasia of the uterus (HP:0008684)1.56341558
96Pancytopenia (HP:0001876)1.56221529
97Aplasia/Hypoplasia of the tongue (HP:0010295)1.55493331
98Abnormality of alanine metabolism (HP:0010916)1.55379352
99Hyperalaninemia (HP:0003348)1.55379352
100Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.55379352

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.04355319
2STK163.26245294
3MAP3K122.68073494
4ZAK2.64881203
5NME12.64153983
6BUB12.59285130
7VRK12.55702507
8WNK32.50810976
9CDC71.96113484
10TLK11.95344276
11DYRK21.94780616
12NUAK11.86145409
13PBK1.79103707
14CDK191.69542046
15MST41.67134871
16ADRBK21.65533518
17BCKDK1.65504304
18SRPK11.64595005
19BMPR1B1.63235920
20NME21.59935278
21MAP4K21.59175770
22TAF11.58962358
23PINK11.45459747
24NEK11.41568900
25GRK11.37997682
26CASK1.33285181
27FRK1.29488326
28PNCK1.25066085
29PLK31.23517845
30EPHB21.21494625
31WEE11.20281709
32MAP2K71.19372772
33TNIK1.16549509
34INSRR1.14576022
35MAP3K41.13462500
36PLK41.10464221
37OXSR11.04297022
38PRKCG1.00068988
39MARK10.99061683
40EIF2AK10.97683906
41MAPK130.96431327
42PASK0.95424206
43EPHA40.94851248
44DYRK30.94840088
45CSNK1G20.92891744
46CSNK1G30.90115489
47OBSCN0.90104344
48LIMK10.88389706
49PLK10.86893593
50WNK40.86821142
51PHKG20.86049316
52PHKG10.86049316
53MYLK0.79257986
54MUSK0.78193538
55DAPK30.76799083
56TRIM280.76073171
57CSNK1G10.75418884
58AURKB0.73092316
59CSNK2A20.71701105
60PDK20.71356638
61MINK10.71078649
62TTK0.70521522
63MKNK10.68295911
64PLK20.68287238
65RPS6KA50.67313869
66PAK30.66827650
67EIF2AK30.66739529
68ABL20.66550422
69CHEK20.66507550
70GRK70.66140090
71AURKA0.65832727
72ADRBK10.65604893
73CSNK2A10.63955745
74MAPK150.63435623
75GRK50.62716932
76CCNB10.61528563
77BRSK20.61482515
78CDK80.60326529
79MAPKAPK50.58055719
80NTRK20.57044218
81CSNK1A1L0.54566625
82LRRK20.53148471
83ILK0.52438744
84PRKCE0.51729198
85PRKACA0.51436629
86TESK20.48168491
87MAP2K40.47623029
88CSNK1E0.47363928
89CAMK2A0.47122287
90TAOK30.46108179
91CSNK1A10.45564244
92ATR0.44541645
93NEK20.43858901
94CAMK10.42611655
95MAP3K110.42400719
96TXK0.41822190
97DAPK10.41031496
98TGFBR10.40122076
99CDK30.39758465
100PRKG10.39586354

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.54004964
2Ribosome_Homo sapiens_hsa030105.47955883
3Parkinsons disease_Homo sapiens_hsa050124.70765700
4Proteasome_Homo sapiens_hsa030503.68072602
5Huntingtons disease_Homo sapiens_hsa050163.33178899
6Alzheimers disease_Homo sapiens_hsa050103.27875963
7Protein export_Homo sapiens_hsa030602.85644468
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.85380443
9Cardiac muscle contraction_Homo sapiens_hsa042602.82612532
10RNA polymerase_Homo sapiens_hsa030202.66830827
11Homologous recombination_Homo sapiens_hsa034401.97205638
12Mismatch repair_Homo sapiens_hsa034301.95632659
13DNA replication_Homo sapiens_hsa030301.64393443
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.51068349
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42783665
16Spliceosome_Homo sapiens_hsa030401.39392957
17Nucleotide excision repair_Homo sapiens_hsa034201.34736715
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.33497192
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.33484208
20Pyrimidine metabolism_Homo sapiens_hsa002401.26029111
21Basal transcription factors_Homo sapiens_hsa030221.23778767
22Fanconi anemia pathway_Homo sapiens_hsa034601.20774887
23Folate biosynthesis_Homo sapiens_hsa007901.17664564
24RNA degradation_Homo sapiens_hsa030181.17635201
25Nicotine addiction_Homo sapiens_hsa050331.14259482
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.13667981
27Collecting duct acid secretion_Homo sapiens_hsa049661.12157039
28Propanoate metabolism_Homo sapiens_hsa006401.07151244
29Phototransduction_Homo sapiens_hsa047441.04788579
30Purine metabolism_Homo sapiens_hsa002301.04483409
31Butanoate metabolism_Homo sapiens_hsa006501.03945629
32Base excision repair_Homo sapiens_hsa034101.03019579
33Glutathione metabolism_Homo sapiens_hsa004801.01417626
34One carbon pool by folate_Homo sapiens_hsa006700.96311303
35Fatty acid elongation_Homo sapiens_hsa000620.93630822
36Pyruvate metabolism_Homo sapiens_hsa006200.89833974
37Maturity onset diabetes of the young_Homo sapiens_hsa049500.87484066
38Peroxisome_Homo sapiens_hsa041460.85602835
39Nitrogen metabolism_Homo sapiens_hsa009100.84871655
40RNA transport_Homo sapiens_hsa030130.84572598
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.83955642
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.83594734
43Metabolic pathways_Homo sapiens_hsa011000.82574844
44Sulfur relay system_Homo sapiens_hsa041220.80163110
45Tryptophan metabolism_Homo sapiens_hsa003800.76901095
46Sulfur metabolism_Homo sapiens_hsa009200.72576333
47Chemical carcinogenesis_Homo sapiens_hsa052040.71114565
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71112577
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70537579
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70305440
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67339929
52Linoleic acid metabolism_Homo sapiens_hsa005910.64043109
53Selenocompound metabolism_Homo sapiens_hsa004500.63558694
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.61190785
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.60263806
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59057101
57Regulation of autophagy_Homo sapiens_hsa041400.56931762
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53883328
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.51854794
60Non-homologous end-joining_Homo sapiens_hsa034500.51407608
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48173828
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47961858
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46244212
64GABAergic synapse_Homo sapiens_hsa047270.46076091
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45404133
66Olfactory transduction_Homo sapiens_hsa047400.45115412
67Tyrosine metabolism_Homo sapiens_hsa003500.43987638
68Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.43793408
69Morphine addiction_Homo sapiens_hsa050320.43551309
70Taste transduction_Homo sapiens_hsa047420.41317221
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.41105350
72Vitamin digestion and absorption_Homo sapiens_hsa049770.41047158
73Caffeine metabolism_Homo sapiens_hsa002320.40370626
74Synaptic vesicle cycle_Homo sapiens_hsa047210.40140316
75Retinol metabolism_Homo sapiens_hsa008300.38349779
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37745362
77Mineral absorption_Homo sapiens_hsa049780.36867467
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34669955
79beta-Alanine metabolism_Homo sapiens_hsa004100.33924905
80Fatty acid degradation_Homo sapiens_hsa000710.33768030
81Arachidonic acid metabolism_Homo sapiens_hsa005900.32257695
82Fat digestion and absorption_Homo sapiens_hsa049750.31773634
83Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.30409887
84Serotonergic synapse_Homo sapiens_hsa047260.30402321
85Arginine and proline metabolism_Homo sapiens_hsa003300.29979342
86Steroid biosynthesis_Homo sapiens_hsa001000.29066107
87Carbon metabolism_Homo sapiens_hsa012000.28028302
88Basal cell carcinoma_Homo sapiens_hsa052170.27039682
89Cell cycle_Homo sapiens_hsa041100.26864128
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.25841166
91Systemic lupus erythematosus_Homo sapiens_hsa053220.24953272
92Asthma_Homo sapiens_hsa053100.24628038
932-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.24496182
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.23971237
95Oocyte meiosis_Homo sapiens_hsa041140.23151723
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.22586755
97Fatty acid metabolism_Homo sapiens_hsa012120.22390610
98Ether lipid metabolism_Homo sapiens_hsa005650.21742540
99Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.21390431
100Circadian entrainment_Homo sapiens_hsa047130.20444147

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