C14ORF178

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-fucose metabolic process (GO:0042354)4.46063624
2L-fucose catabolic process (GO:0042355)4.46063624
3fucose catabolic process (GO:0019317)4.46063624
4behavioral response to nicotine (GO:0035095)4.39739175
5response to pheromone (GO:0019236)4.20030021
6piRNA metabolic process (GO:0034587)3.71663331
7platelet dense granule organization (GO:0060155)3.71068471
8indole-containing compound catabolic process (GO:0042436)3.65175271
9indolalkylamine catabolic process (GO:0046218)3.65175271
10tryptophan catabolic process (GO:0006569)3.65175271
11negative regulation of mast cell activation (GO:0033004)3.61405526
12DNA double-strand break processing (GO:0000729)3.58443263
13water-soluble vitamin biosynthetic process (GO:0042364)3.50403981
14indolalkylamine metabolic process (GO:0006586)3.44940315
15kynurenine metabolic process (GO:0070189)3.32130018
16respiratory chain complex IV assembly (GO:0008535)3.31997348
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.27153153
18detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.23210625
19cornea development in camera-type eye (GO:0061303)3.22971087
20adaptation of signaling pathway (GO:0023058)3.17774287
21cytochrome complex assembly (GO:0017004)3.16630594
22nonmotile primary cilium assembly (GO:0035058)3.13575800
23protein complex biogenesis (GO:0070271)3.12503159
24regulation of memory T cell differentiation (GO:0043380)3.11119365
25DNA deamination (GO:0045006)3.10157475
26tryptophan metabolic process (GO:0006568)3.08461465
27detection of light stimulus involved in sensory perception (GO:0050962)3.07745779
28detection of light stimulus involved in visual perception (GO:0050908)3.07745779
29protein-cofactor linkage (GO:0018065)3.07333292
30male meiosis I (GO:0007141)3.02248207
31replication fork processing (GO:0031297)3.00623316
32negative regulation of telomere maintenance (GO:0032205)2.99227784
33regulation of hexokinase activity (GO:1903299)2.99031177
34regulation of glucokinase activity (GO:0033131)2.99031177
35DNA methylation involved in gamete generation (GO:0043046)2.97633017
36axoneme assembly (GO:0035082)2.97421275
37neural tube formation (GO:0001841)2.95935280
38ubiquinone biosynthetic process (GO:0006744)2.95923375
39cilium morphogenesis (GO:0060271)2.92701393
40cellular ketone body metabolic process (GO:0046950)2.91990774
41mannosylation (GO:0097502)2.88863119
42amine catabolic process (GO:0009310)2.83965942
43cellular biogenic amine catabolic process (GO:0042402)2.83965942
44protein localization to cilium (GO:0061512)2.83828954
45mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.83572353
46mitochondrial respiratory chain complex I assembly (GO:0032981)2.83572353
47NADH dehydrogenase complex assembly (GO:0010257)2.83572353
48epithelial cilium movement (GO:0003351)2.79355653
49RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.79341011
50tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.79341011
51photoreceptor cell maintenance (GO:0045494)2.79092602
52mitochondrial respiratory chain complex assembly (GO:0033108)2.78123590
53ubiquinone metabolic process (GO:0006743)2.77262776
54auditory receptor cell stereocilium organization (GO:0060088)2.76889073
55inositol phosphate catabolic process (GO:0071545)2.74180692
56ketone body metabolic process (GO:1902224)2.73681791
57recombinational repair (GO:0000725)2.69912161
58double-strand break repair via homologous recombination (GO:0000724)2.68097765
59gamma-aminobutyric acid transport (GO:0015812)2.67770541
60synapsis (GO:0007129)2.65639416
61rhodopsin mediated signaling pathway (GO:0016056)2.64325322
62reflex (GO:0060004)2.64103891
63retinal cone cell development (GO:0046549)2.63319979
64regulation of cilium movement (GO:0003352)2.62415974
65regulation of rhodopsin mediated signaling pathway (GO:0022400)2.62301422
66preassembly of GPI anchor in ER membrane (GO:0016254)2.61501530
67aromatic amino acid family catabolic process (GO:0009074)2.61498437
68inner ear receptor stereocilium organization (GO:0060122)2.61108383
69reciprocal meiotic recombination (GO:0007131)2.60126865
70reciprocal DNA recombination (GO:0035825)2.60126865
71photoreceptor cell development (GO:0042461)2.58295125
72polyol catabolic process (GO:0046174)2.57594789
73regulation of meiosis I (GO:0060631)2.57370360
74oxidative demethylation (GO:0070989)2.55921552
75kidney morphogenesis (GO:0060993)2.54664759
76neuronal action potential (GO:0019228)2.52092843
77cilium organization (GO:0044782)2.51964935
78exogenous drug catabolic process (GO:0042738)2.50627070
79regulation of nuclear cell cycle DNA replication (GO:0033262)2.50552671
80negative regulation of DNA-dependent DNA replication (GO:2000104)2.47548953
81indole-containing compound metabolic process (GO:0042430)2.47500522
82behavioral response to ethanol (GO:0048149)2.44603268
83nucleobase catabolic process (GO:0046113)2.42676697
84drug catabolic process (GO:0042737)2.42313420
85nucleotide transmembrane transport (GO:1901679)2.41682411
86regulation of neurotransmitter uptake (GO:0051580)2.41058939
87L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.41054660
88pyrimidine nucleobase catabolic process (GO:0006208)2.40931655
89peptidyl-histidine modification (GO:0018202)2.40573700
90cilium assembly (GO:0042384)2.40412618
91negative regulation of transcription regulatory region DNA binding (GO:2000678)2.39859004
92protein polyglutamylation (GO:0018095)2.39812064
93glycosphingolipid biosynthetic process (GO:0006688)2.39173935
94regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.37905611
95estrogen biosynthetic process (GO:0006703)2.37829736
96inositol phosphate dephosphorylation (GO:0046855)2.37740336
97phosphorylated carbohydrate dephosphorylation (GO:0046838)2.37740336
98male meiosis (GO:0007140)2.37111542
99positive regulation of defense response to virus by host (GO:0002230)2.36877126
100benzene-containing compound metabolic process (GO:0042537)2.36199745

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.27725471
2VDR_22108803_ChIP-Seq_LS180_Human3.07097594
3IGF1R_20145208_ChIP-Seq_DFB_Human3.06157323
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.88417723
5GBX2_23144817_ChIP-Seq_PC3_Human2.84398992
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.64402576
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.52741947
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.41851316
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.30854800
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.21825623
11EWS_26573619_Chip-Seq_HEK293_Human2.18366512
12FUS_26573619_Chip-Seq_HEK293_Human2.18101508
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.12618186
14CTBP1_25329375_ChIP-Seq_LNCAP_Human2.06165202
15P300_19829295_ChIP-Seq_ESCs_Human2.05524700
16TAF15_26573619_Chip-Seq_HEK293_Human2.05239781
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.01566256
18ER_23166858_ChIP-Seq_MCF-7_Human1.93524443
19SALL1_21062744_ChIP-ChIP_HESCs_Human1.86454235
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.82566928
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.80194553
22EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.72733323
23BCAT_22108803_ChIP-Seq_LS180_Human1.70133561
24TP53_22573176_ChIP-Seq_HFKS_Human1.64876988
25AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.61807279
26IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.61715599
27CBP_20019798_ChIP-Seq_JUKART_Human1.61715599
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.61089016
29MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.59198569
30UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.54196384
31GABP_17652178_ChIP-ChIP_JURKAT_Human1.51537406
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.49713417
33* STAT3_23295773_ChIP-Seq_U87_Human1.47874367
34AR_25329375_ChIP-Seq_VCAP_Human1.47662068
35IRF1_19129219_ChIP-ChIP_H3396_Human1.47445049
36SMAD4_21799915_ChIP-Seq_A2780_Human1.47300058
37GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.47097397
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.44138622
39RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43847084
40MYC_18940864_ChIP-ChIP_HL60_Human1.43261993
41EZH2_22144423_ChIP-Seq_EOC_Human1.42584520
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40914411
43TCF4_23295773_ChIP-Seq_U87_Human1.39986229
44* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.39833044
45* FOXA1_25329375_ChIP-Seq_VCAP_Human1.39833044
46HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.39100475
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.39075644
48PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38727539
49SOX2_19829295_ChIP-Seq_ESCs_Human1.38582021
50NANOG_19829295_ChIP-Seq_ESCs_Human1.38582021
51BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37146390
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36186495
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36056218
54SUZ12_27294783_Chip-Seq_NPCs_Mouse1.35907819
55NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33125059
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32965381
57NFE2_27457419_Chip-Seq_LIVER_Mouse1.31371519
58TCF4_22108803_ChIP-Seq_LS180_Human1.30605528
59EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.27479096
60KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.27201770
61NCOR_22424771_ChIP-Seq_293T_Human1.26470883
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.25403223
63ETV2_25802403_ChIP-Seq_MESCs_Mouse1.24374780
64AR_20517297_ChIP-Seq_VCAP_Human1.23008724
65EST1_17652178_ChIP-ChIP_JURKAT_Human1.22501918
66RUNX2_22187159_ChIP-Seq_PCA_Human1.22426475
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22244617
68BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.20964980
69* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.20935272
70CRX_20693478_ChIP-Seq_RETINA_Mouse1.20314239
71PRDM14_20953172_ChIP-Seq_ESCs_Human1.20132062
72KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20083521
73CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19774678
74FLI1_21867929_ChIP-Seq_TH2_Mouse1.16878088
75SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16542677
76RNF2_27304074_Chip-Seq_NSC_Mouse1.14893958
77SMAD4_21741376_ChIP-Seq_EPCs_Human1.14736409
78CBX2_27304074_Chip-Seq_ESCs_Mouse1.14571224
79HOXB7_26014856_ChIP-Seq_BT474_Human1.13191212
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.12977600
81REST_21632747_ChIP-Seq_MESCs_Mouse1.12526835
82GATA3_21878914_ChIP-Seq_MCF-7_Human1.11945838
83AUTS2_25519132_ChIP-Seq_293T-REX_Human1.11602708
84EGR1_23403033_ChIP-Seq_LIVER_Mouse1.10469601
85* VDR_23849224_ChIP-Seq_CD4+_Human1.10300281
86TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08012548
87CDX2_22108803_ChIP-Seq_LS180_Human1.06790495
88EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06462964
89P53_22387025_ChIP-Seq_ESCs_Mouse1.06361579
90CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.06098477
91OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04925482
92POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03742536
93TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03742536
94ELK1_19687146_ChIP-ChIP_HELA_Human1.01148955
95TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00421696
96OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00413120
97STAT3_18555785_Chip-Seq_ESCs_Mouse0.99485567
98SRF_21415370_ChIP-Seq_HL-1_Mouse0.98509638
99PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97624836
100SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.96793101

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis3.38987559
2MP0008877_abnormal_DNA_methylation3.30062234
3MP0002102_abnormal_ear_morphology2.91971921
4MP0005551_abnormal_eye_electrophysiolog2.61379510
5MP0001986_abnormal_taste_sensitivity2.58493667
6MP0003195_calcinosis2.56222737
7MP0000372_irregular_coat_pigmentation2.40110889
8MP0006072_abnormal_retinal_apoptosis2.37228522
9MP0003787_abnormal_imprinting2.33150655
10MP0001968_abnormal_touch/_nociception2.30666589
11MP0005646_abnormal_pituitary_gland2.25987989
12MP0002653_abnormal_ependyma_morphology2.25622128
13MP0009046_muscle_twitch2.06281212
14MP0002876_abnormal_thyroid_physiology2.05742604
15MP0008872_abnormal_physiological_respon2.05131388
16MP0008875_abnormal_xenobiotic_pharmacok2.02296088
17MP0001984_abnormal_olfaction1.97962915
18MP0002736_abnormal_nociception_after1.87651738
19MP0006292_abnormal_olfactory_placode1.85996645
20MP0001501_abnormal_sleep_pattern1.81636943
21MP0005253_abnormal_eye_physiology1.81170305
22MP0003011_delayed_dark_adaptation1.77564718
23MP0004885_abnormal_endolymph1.68658980
24MP0005075_abnormal_melanosome_morpholog1.67883488
25MP0004043_abnormal_pH_regulation1.67453308
26MP0005645_abnormal_hypothalamus_physiol1.65424714
27MP0002638_abnormal_pupillary_reflex1.60422422
28MP0009745_abnormal_behavioral_response1.58141063
29MP0003646_muscle_fatigue1.54737766
30MP0000569_abnormal_digit_pigmentation1.54027585
31MP0002163_abnormal_gland_morphology1.52559711
32MP0005084_abnormal_gallbladder_morpholo1.52364228
33MP0002938_white_spotting1.50884249
34MP0002272_abnormal_nervous_system1.50466762
35MP0002234_abnormal_pharynx_morphology1.49062813
36MP0004142_abnormal_muscle_tone1.48630659
37MP0003880_abnormal_central_pattern1.48387056
38MP0005379_endocrine/exocrine_gland_phen1.47835383
39MP0003252_abnormal_bile_duct1.45635245
40MP0000631_abnormal_neuroendocrine_gland1.44110078
41MP0005174_abnormal_tail_pigmentation1.43864024
42MP0003136_yellow_coat_color1.42142855
43MP0008058_abnormal_DNA_repair1.41188263
44MP0002735_abnormal_chemical_nociception1.37527254
45MP0001764_abnormal_homeostasis1.37269858
46MP0010386_abnormal_urinary_bladder1.37006909
47MP0006276_abnormal_autonomic_nervous1.34058723
48MP0001486_abnormal_startle_reflex1.33241778
49MP0008995_early_reproductive_senescence1.30104468
50MP0005389_reproductive_system_phenotype1.27279179
51MP0000516_abnormal_urinary_system1.25702140
52MP0005367_renal/urinary_system_phenotyp1.25702140
53MP0002928_abnormal_bile_duct1.24305247
54MP0005386_behavior/neurological_phenoty1.20013981
55MP0004924_abnormal_behavior1.20013981
56MP0004133_heterotaxia1.19284464
57MP0002733_abnormal_thermal_nociception1.18639708
58MP0002160_abnormal_reproductive_system1.16486489
59MP0000427_abnormal_hair_cycle1.15272233
60MP0001485_abnormal_pinna_reflex1.13057191
61MP0002572_abnormal_emotion/affect_behav1.12455182
62MP0004147_increased_porphyrin_level1.09777377
63MP0005332_abnormal_amino_acid1.08593521
64MP0002693_abnormal_pancreas_physiology1.07879647
65MP0001970_abnormal_pain_threshold1.06324431
66MP0003121_genomic_imprinting1.06125216
67MP0004215_abnormal_myocardial_fiber1.04730956
68MP0003718_maternal_effect1.03700341
69MP0002064_seizures1.00313449
70MP0005410_abnormal_fertilization0.99700610
71MP0001919_abnormal_reproductive_system0.99298389
72MP0002557_abnormal_social/conspecific_i0.95391591
73MP0004742_abnormal_vestibular_system0.93609108
74MP0005085_abnormal_gallbladder_physiolo0.91637064
75MP0002095_abnormal_skin_pigmentation0.90785826
76MP0000538_abnormal_urinary_bladder0.88670366
77MP0006054_spinal_hemorrhage0.88499997
78MP0001929_abnormal_gametogenesis0.87656416
79MP0003698_abnormal_male_reproductive0.87099398
80MP0003186_abnormal_redox_activity0.85330039
81MP0010329_abnormal_lipoprotein_level0.84393980
82MP0005195_abnormal_posterior_eye0.84224411
83MP0008789_abnormal_olfactory_epithelium0.83479450
84MP0000653_abnormal_sex_gland0.83004334
85MP0004145_abnormal_muscle_electrophysio0.82469171
86MP0002751_abnormal_autonomic_nervous0.82181927
87MP0002734_abnormal_mechanical_nocicepti0.81935595
88MP0002138_abnormal_hepatobiliary_system0.81729986
89MP0002067_abnormal_sensory_capabilities0.80594740
90MP0001324_abnormal_eye_pigmentation0.80449838
91MP0002210_abnormal_sex_determination0.78780797
92MP0003122_maternal_imprinting0.78678262
93MP0003137_abnormal_impulse_conducting0.77941813
94MP0006036_abnormal_mitochondrial_physio0.77629879
95MP0001145_abnormal_male_reproductive0.77394334
96MP0002063_abnormal_learning/memory/cond0.76877765
97MP0002229_neurodegeneration0.75780152
98MP0005220_abnormal_exocrine_pancreas0.75322309
99MP0001944_abnormal_pancreas_morphology0.74548849
100MP0000383_abnormal_hair_follicle0.74410237

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.41696221
2True hermaphroditism (HP:0010459)4.28367158
3Pancreatic fibrosis (HP:0100732)4.21282585
4Congenital stationary night blindness (HP:0007642)3.93160724
5Nephronophthisis (HP:0000090)3.75676849
6Abnormality of midbrain morphology (HP:0002418)3.71613286
7Molar tooth sign on MRI (HP:0002419)3.71613286
8Chronic hepatic failure (HP:0100626)3.57997801
9Abnormality of the renal cortex (HP:0011035)3.44582567
10Abnormality of the renal medulla (HP:0100957)3.23786111
11Hyperventilation (HP:0002883)3.21772599
12Medial flaring of the eyebrow (HP:0010747)3.19893828
13Tubular atrophy (HP:0000092)2.98346661
14Renal cortical cysts (HP:0000803)2.81549964
15Abnormal rod and cone electroretinograms (HP:0008323)2.80740008
16Cystic liver disease (HP:0006706)2.79724435
17Abolished electroretinogram (ERG) (HP:0000550)2.74410638
18Attenuation of retinal blood vessels (HP:0007843)2.73934436
19Type II lissencephaly (HP:0007260)2.73442117
20Progressive inability to walk (HP:0002505)2.69960709
21Abnormal drinking behavior (HP:0030082)2.68361008
22Polydipsia (HP:0001959)2.68361008
23Gaze-evoked nystagmus (HP:0000640)2.64063067
24Bile duct proliferation (HP:0001408)2.58885314
25Abnormal biliary tract physiology (HP:0012439)2.58885314
26Inability to walk (HP:0002540)2.49596347
27Gait imbalance (HP:0002141)2.35985785
28Pendular nystagmus (HP:0012043)2.35472057
29Sclerocornea (HP:0000647)2.33875195
30Methylmalonic acidemia (HP:0002912)2.31983713
31Congenital primary aphakia (HP:0007707)2.31379510
32Absent/shortened dynein arms (HP:0200106)2.28689261
33Dynein arm defect of respiratory motile cilia (HP:0012255)2.28689261
34Male pseudohermaphroditism (HP:0000037)2.22747913
35Absent rod-and cone-mediated responses on ERG (HP:0007688)2.19839641
36Increased CSF lactate (HP:0002490)2.17698058
37Keratoconus (HP:0000563)2.17234563
38Increased corneal curvature (HP:0100692)2.17234563
39Abnormality of the labia minora (HP:0012880)2.17171829
40Ketoacidosis (HP:0001993)2.16099475
41Congenital hepatic fibrosis (HP:0002612)2.15772585
42Nephrogenic diabetes insipidus (HP:0009806)2.15380057
43Intestinal atresia (HP:0011100)2.13442732
44Mitochondrial inheritance (HP:0001427)2.12287033
45Aplasia/Hypoplasia of the spleen (HP:0010451)2.12265727
46Polyuria (HP:0000103)2.11738501
47Aplasia/Hypoplasia of the tongue (HP:0010295)2.08244220
48Furrowed tongue (HP:0000221)2.07643642
49Acute necrotizing encephalopathy (HP:0006965)2.06182239
50Anencephaly (HP:0002323)2.05001342
51Progressive macrocephaly (HP:0004481)2.04775880
52Hypothermia (HP:0002045)2.02567084
53Methylmalonic aciduria (HP:0012120)2.02544889
54Decreased central vision (HP:0007663)2.00071851
55Thyroiditis (HP:0100646)1.99338211
56Abnormal respiratory motile cilium morphology (HP:0005938)1.98738023
57Abnormal respiratory epithelium morphology (HP:0012253)1.98738023
58Ketosis (HP:0001946)1.98649574
59Aplasia/Hypoplasia of the fovea (HP:0008060)1.98258266
60Hypoplasia of the fovea (HP:0007750)1.98258266
61Hepatic necrosis (HP:0002605)1.96703260
62Hemiparesis (HP:0001269)1.96207953
63Lissencephaly (HP:0001339)1.95892784
64Genital tract atresia (HP:0001827)1.93232210
65Stomach cancer (HP:0012126)1.92896968
66Hepatocellular necrosis (HP:0001404)1.92606966
67Aplasia/hypoplasia of the uterus (HP:0008684)1.92548822
68Hyperglycinuria (HP:0003108)1.91694131
69Progressive cerebellar ataxia (HP:0002073)1.91175077
70Asplenia (HP:0001746)1.91151195
71Dyskinesia (HP:0100660)1.90599134
72Congenital sensorineural hearing impairment (HP:0008527)1.89256760
73Tachypnea (HP:0002789)1.88439090
74Hyperglycinemia (HP:0002154)1.88205649
75Postaxial foot polydactyly (HP:0001830)1.87668392
763-Methylglutaconic aciduria (HP:0003535)1.86882033
77Acute encephalopathy (HP:0006846)1.86482481
78Broad-based gait (HP:0002136)1.84247754
79Decreased electroretinogram (ERG) amplitude (HP:0000654)1.83470880
80Vaginal atresia (HP:0000148)1.81013173
81Bony spicule pigmentary retinopathy (HP:0007737)1.79447443
82Febrile seizures (HP:0002373)1.75810501
83Aplasia/Hypoplasia of the tibia (HP:0005772)1.74384691
84Pachygyria (HP:0001302)1.74313699
85Lipid accumulation in hepatocytes (HP:0006561)1.74242205
86Optic disc pallor (HP:0000543)1.73879574
87Postaxial hand polydactyly (HP:0001162)1.73461965
88Abnormality of serine family amino acid metabolism (HP:0010894)1.73443075
89Abnormality of glycine metabolism (HP:0010895)1.73443075
90Tubulointerstitial nephritis (HP:0001970)1.73330227
91Increased serum lactate (HP:0002151)1.73183123
92Hypoplasia of the uterus (HP:0000013)1.71655091
93Protruding tongue (HP:0010808)1.71369019
94Absent speech (HP:0001344)1.70960648
95Abnormality of alanine metabolism (HP:0010916)1.70367062
96Hyperalaninemia (HP:0003348)1.70367062
97Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.70367062
98Abnormal ciliary motility (HP:0012262)1.70000352
99Mesangial abnormality (HP:0001966)1.69375170
100Large for gestational age (HP:0001520)1.69323303

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.77552225
2MAP4K23.35239113
3ADRBK23.00396448
4NUAK12.76741994
5GRK12.71998597
6MAPK132.52315428
7TXK2.28979672
8BMPR1B2.27545740
9PINK12.21430478
10WNK32.17984188
11ZAK2.14296615
12CASK2.08248644
13ACVR1B1.97309247
14TRIM281.83780315
15INSRR1.76925645
16WNK41.75470230
17TAOK31.67080215
18PASK1.65731173
19TLK11.54840418
20MST41.40041855
21PAK31.39579800
22PLK21.38246138
23DAPK21.36194997
24NTRK31.28518614
25FGFR21.27929229
26OXSR11.27860508
27EIF2AK31.25798467
28BCKDK1.19768218
29MAP3K41.14959470
30PRKCE1.12634812
31ADRBK11.11056171
32MKNK21.10894013
33PHKG21.10638423
34PHKG11.10638423
35STK391.06198508
36CSNK1G31.04878881
37CSNK1G11.04242293
38ERBB31.03025737
39CSNK1G21.03014351
40TNIK1.01503184
41PLK40.93649166
42MAPKAPK30.92503496
43CAMKK20.87495823
44MARK10.87187496
45TEC0.85153081
46CDK190.81713059
47PRKCG0.80357729
48CSNK1A1L0.80140851
49EPHA40.80118964
50PRKCQ0.77008275
51TNK20.76111222
52STK38L0.75458156
53VRK10.72432320
54BRSK20.71506724
55CCNB10.69594474
56STK110.68925343
57DYRK20.68777781
58IKBKB0.68143899
59PTK2B0.65756066
60ITK0.65656955
61PRKCI0.64920510
62MAP2K70.60560572
63FER0.59774155
64CAMKK10.59129138
65PKN10.58174064
66TGFBR10.57249545
67MAP2K60.57111065
68PLK30.56873411
69NEK10.52452732
70CAMK2A0.49868394
71GRK70.49147199
72PRKACA0.49036509
73STK30.48745286
74BCR0.46311032
75FLT30.45832741
76MKNK10.45203930
77CSNK1A10.44677844
78EIF2AK10.42542887
79GRK50.42133127
80TIE10.42038705
81RPS6KA50.41807208
82KIT0.41781792
83PIK3CA0.41746692
84EIF2AK20.39984180
85PRKCZ0.37542408
86AKT30.36947632
87CSNK1D0.36629702
88MAPKAPK50.36622863
89SYK0.35635823
90PRKCA0.34625638
91IGF1R0.33111708
92NME10.32106679
93MUSK0.31200195
94PRKG10.30273621
95PRKACB0.29646254
96NTRK20.29157317
97CAMK2D0.29113375
98TRPM70.28687496
99ATM0.27754679
100LYN0.27633203

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.15712969
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.66036722
3Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.53086594
4Linoleic acid metabolism_Homo sapiens_hsa005912.50775140
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.33643507
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.30831616
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.30805222
8Nitrogen metabolism_Homo sapiens_hsa009102.30585763
9Butanoate metabolism_Homo sapiens_hsa006502.30545684
10Caffeine metabolism_Homo sapiens_hsa002322.24454541
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.16653830
12Protein export_Homo sapiens_hsa030602.14120036
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.03667734
14Ether lipid metabolism_Homo sapiens_hsa005651.90890998
15Homologous recombination_Homo sapiens_hsa034401.85386790
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.83128955
17Tryptophan metabolism_Homo sapiens_hsa003801.77238994
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.72161729
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.68557007
20Basal transcription factors_Homo sapiens_hsa030221.65945919
21Fanconi anemia pathway_Homo sapiens_hsa034601.65286106
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.64244088
23Propanoate metabolism_Homo sapiens_hsa006401.62150847
24Oxidative phosphorylation_Homo sapiens_hsa001901.59877841
25RNA polymerase_Homo sapiens_hsa030201.58284768
26Selenocompound metabolism_Homo sapiens_hsa004501.49071102
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.45729678
28Nicotine addiction_Homo sapiens_hsa050331.43722882
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.32321720
30Asthma_Homo sapiens_hsa053101.31426500
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.30431702
32Olfactory transduction_Homo sapiens_hsa047401.27171447
33Chemical carcinogenesis_Homo sapiens_hsa052041.27024176
34Regulation of autophagy_Homo sapiens_hsa041401.21597054
35Insulin secretion_Homo sapiens_hsa049111.21487398
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.21315743
37Taste transduction_Homo sapiens_hsa047421.20595858
38Peroxisome_Homo sapiens_hsa041461.17897825
39Retinol metabolism_Homo sapiens_hsa008301.12387800
40Primary bile acid biosynthesis_Homo sapiens_hsa001201.08257720
41Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.07041689
42Arachidonic acid metabolism_Homo sapiens_hsa005901.06367590
43Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.03218043
44Type I diabetes mellitus_Homo sapiens_hsa049401.02646022
45Parkinsons disease_Homo sapiens_hsa050121.02366648
46Non-homologous end-joining_Homo sapiens_hsa034500.99811652
47One carbon pool by folate_Homo sapiens_hsa006700.99735567
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.98438812
49Morphine addiction_Homo sapiens_hsa050320.96973637
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.93118848
51Primary immunodeficiency_Homo sapiens_hsa053400.91835019
52RNA degradation_Homo sapiens_hsa030180.88914238
53ABC transporters_Homo sapiens_hsa020100.82901893
54Serotonergic synapse_Homo sapiens_hsa047260.81680217
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80860679
56Collecting duct acid secretion_Homo sapiens_hsa049660.79218965
57Glycerolipid metabolism_Homo sapiens_hsa005610.77681869
58Circadian entrainment_Homo sapiens_hsa047130.77549714
59Fatty acid elongation_Homo sapiens_hsa000620.76598912
60Ovarian steroidogenesis_Homo sapiens_hsa049130.76504560
61Steroid biosynthesis_Homo sapiens_hsa001000.75398957
62Salivary secretion_Homo sapiens_hsa049700.75301250
63GABAergic synapse_Homo sapiens_hsa047270.71901118
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68296175
65Metabolic pathways_Homo sapiens_hsa011000.67087960
66Glutamatergic synapse_Homo sapiens_hsa047240.66591205
67Fat digestion and absorption_Homo sapiens_hsa049750.65664842
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65539092
69Allograft rejection_Homo sapiens_hsa053300.65301914
70Purine metabolism_Homo sapiens_hsa002300.62972933
71Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.60903834
72Fatty acid metabolism_Homo sapiens_hsa012120.60237239
73beta-Alanine metabolism_Homo sapiens_hsa004100.59481440
74Sulfur metabolism_Homo sapiens_hsa009200.59222365
75Graft-versus-host disease_Homo sapiens_hsa053320.58233814
76Huntingtons disease_Homo sapiens_hsa050160.57858873
77Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.56999542
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55231652
79Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.55080143
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54375022
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54036532
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53922422
83Autoimmune thyroid disease_Homo sapiens_hsa053200.53887748
84Alzheimers disease_Homo sapiens_hsa050100.50252912
85Mineral absorption_Homo sapiens_hsa049780.49912837
86Sphingolipid metabolism_Homo sapiens_hsa006000.49789718
87Folate biosynthesis_Homo sapiens_hsa007900.48844262
88Histidine metabolism_Homo sapiens_hsa003400.48656830
89Pyrimidine metabolism_Homo sapiens_hsa002400.48380607
90Calcium signaling pathway_Homo sapiens_hsa040200.47288654
91Cardiac muscle contraction_Homo sapiens_hsa042600.46885323
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46829784
93Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.46119117
94Fatty acid degradation_Homo sapiens_hsa000710.45583829
95Dorso-ventral axis formation_Homo sapiens_hsa043200.43856060
96Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43512951
97Long-term depression_Homo sapiens_hsa047300.43453605
98Dopaminergic synapse_Homo sapiens_hsa047280.43362455
99Rheumatoid arthritis_Homo sapiens_hsa053230.42196742
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.42158712

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