C14ORF142

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)7.72305700
2cilium movement (GO:0003341)5.80378547
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.74070336
4epithelial cilium movement (GO:0003351)5.65431730
5cilium or flagellum-dependent cell motility (GO:0001539)5.50731749
6proteasome assembly (GO:0043248)5.24172896
7motile cilium assembly (GO:0044458)5.04020701
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.97719390
9energy coupled proton transport, down electrochemical gradient (GO:0015985)4.91937927
10ATP synthesis coupled proton transport (GO:0015986)4.91937927
11establishment of protein localization to mitochondrial membrane (GO:0090151)4.75548981
12protein neddylation (GO:0045116)4.50666005
13mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.45424982
14CENP-A containing nucleosome assembly (GO:0034080)4.23236643
15negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.18729286
16respiratory electron transport chain (GO:0022904)4.13554229
17chromatin remodeling at centromere (GO:0031055)4.11034260
18electron transport chain (GO:0022900)4.08457460
19regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.93632638
20positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.93065535
21regulation of cellular amino acid metabolic process (GO:0006521)3.80112856
22intraciliary transport (GO:0042073)3.78296697
23negative regulation of ligase activity (GO:0051352)3.77411163
24negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.77411163
25anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.74828296
26regulation of cilium movement (GO:0003352)3.68372541
27protein complex biogenesis (GO:0070271)3.56344494
28axoneme assembly (GO:0035082)3.54149034
29establishment of integrated proviral latency (GO:0075713)3.52424736
30chaperone-mediated protein transport (GO:0072321)3.51336396
31DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.48009403
32cullin deneddylation (GO:0010388)3.47374671
33pseudouridine synthesis (GO:0001522)3.43811385
34regulation of mitochondrial translation (GO:0070129)3.41806096
35mitochondrial respiratory chain complex assembly (GO:0033108)3.41774912
36intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.40057301
37signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.40057301
38mitochondrial respiratory chain complex I assembly (GO:0032981)3.39316933
39NADH dehydrogenase complex assembly (GO:0010257)3.39316933
40mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.39316933
41signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.38935041
42signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.38935041
43signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.38935041
44histone exchange (GO:0043486)3.35557932
45positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.34625293
46telomere maintenance via semi-conservative replication (GO:0032201)3.30775016
47centriole replication (GO:0007099)3.30498861
48centriole assembly (GO:0098534)3.28238346
49signal transduction involved in DNA damage checkpoint (GO:0072422)3.27672607
50signal transduction involved in DNA integrity checkpoint (GO:0072401)3.27672607
51DNA double-strand break processing (GO:0000729)3.26547819
52signal transduction involved in cell cycle checkpoint (GO:0072395)3.23697141
53positive regulation of ligase activity (GO:0051351)3.23299039
54RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.22929305
55tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.22929305
56nucleoside diphosphate phosphorylation (GO:0006165)3.19683483
57GTP biosynthetic process (GO:0006183)3.18113632
58DNA strand elongation involved in DNA replication (GO:0006271)3.17081635
59protein deneddylation (GO:0000338)3.17034235
60nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.12188884
61protein targeting to mitochondrion (GO:0006626)3.12108495
62DNA replication-independent nucleosome assembly (GO:0006336)3.09243550
63DNA replication-independent nucleosome organization (GO:0034724)3.09243550
64deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.08934162
65exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.08449706
66left/right pattern formation (GO:0060972)3.07335539
67purine nucleoside triphosphate biosynthetic process (GO:0009145)3.03692167
68DNA strand elongation (GO:0022616)3.01925647
69respiratory chain complex IV assembly (GO:0008535)3.01171098
70protein localization to mitochondrion (GO:0070585)2.99950987
71oxidative phosphorylation (GO:0006119)2.99612089
72purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.99153431
73regulation of ubiquitin-protein transferase activity (GO:0051438)2.97741348
74pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.96375796
75mitotic metaphase plate congression (GO:0007080)2.96348371
76metaphase plate congression (GO:0051310)2.96328178
77deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.96226087
78establishment of viral latency (GO:0019043)2.95679170
79nucleoside triphosphate biosynthetic process (GO:0009142)2.94004930
80ATP biosynthetic process (GO:0006754)2.93166000
81organelle disassembly (GO:1903008)2.92324951
82telomere maintenance via recombination (GO:0000722)2.92200337
83DNA deamination (GO:0045006)2.91354783
84histone H2A acetylation (GO:0043968)2.91233266
85establishment of protein localization to mitochondrion (GO:0072655)2.90116999
86regulation of ligase activity (GO:0051340)2.89832288
87deoxyribonucleotide biosynthetic process (GO:0009263)2.89696438
88DNA replication checkpoint (GO:0000076)2.89633661
89spliceosomal snRNP assembly (GO:0000387)2.89256708
90purine nucleobase biosynthetic process (GO:0009113)2.88619574
91water-soluble vitamin biosynthetic process (GO:0042364)2.88504980
92regulation of cellular amine metabolic process (GO:0033238)2.87030643
93transcription elongation from RNA polymerase III promoter (GO:0006385)2.86910169
94termination of RNA polymerase III transcription (GO:0006386)2.86910169
95rRNA modification (GO:0000154)2.86466415
96DNA catabolic process, exonucleolytic (GO:0000738)2.85801095
97cilium organization (GO:0044782)2.84889956
98protein K6-linked ubiquitination (GO:0085020)2.84652988
99mitotic recombination (GO:0006312)2.84272712
100cytochrome complex assembly (GO:0017004)2.82179852

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.10478741
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.53360076
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.89240332
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.87963857
5E2F7_22180533_ChIP-Seq_HELA_Human3.76822835
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.32834012
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.27799892
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.07813456
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.98053656
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.95902921
11ELK1_19687146_ChIP-ChIP_HELA_Human2.95218012
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.92903771
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.91140545
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.77935498
15VDR_23849224_ChIP-Seq_CD4+_Human2.75389521
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.61120854
17DCP1A_22483619_ChIP-Seq_HELA_Human2.46338213
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.45773397
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.33163073
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.32880120
21PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.29971528
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.29511476
23SRF_21415370_ChIP-Seq_HL-1_Mouse2.27262178
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.26890426
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.26324469
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.24214557
27FOXP3_21729870_ChIP-Seq_TREG_Human2.22258064
28FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.07147506
29PADI4_21655091_ChIP-ChIP_MCF-7_Human2.05648169
30HOXB4_20404135_ChIP-ChIP_EML_Mouse2.02605562
31VDR_22108803_ChIP-Seq_LS180_Human1.98515309
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.96490457
33* GABP_19822575_ChIP-Seq_HepG2_Human1.90448978
34E2F1_18555785_ChIP-Seq_MESCs_Mouse1.88595091
35CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.86780810
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.84791342
37AR_21909140_ChIP-Seq_LNCAP_Human1.84305050
38PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.83355114
39NELFA_20434984_ChIP-Seq_ESCs_Mouse1.82141786
40ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.77526254
41FOXM1_23109430_ChIP-Seq_U2OS_Human1.69758336
42TTF2_22483619_ChIP-Seq_HELA_Human1.67994967
43EWS_26573619_Chip-Seq_HEK293_Human1.63863300
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.62971844
45XRN2_22483619_ChIP-Seq_HELA_Human1.60810568
46MYC_18940864_ChIP-ChIP_HL60_Human1.58723333
47MYC_19079543_ChIP-ChIP_MESCs_Mouse1.57185451
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55724705
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48744866
50HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.46271340
51* E2F1_21310950_ChIP-Seq_MCF-7_Human1.44796542
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.41935889
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.38991672
54CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.38917531
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.38007160
56MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.28812111
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.25747378
58HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.20622379
59CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.19366961
60ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.19102081
61CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.18630259
62ZNF274_21170338_ChIP-Seq_K562_Hela1.16345127
63POU3F2_20337985_ChIP-ChIP_501MEL_Human1.10918471
64* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10576610
65ZFX_18555785_ChIP-Seq_MESCs_Mouse1.09841109
66FUS_26573619_Chip-Seq_HEK293_Human1.08828785
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07219487
68ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06661432
69EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05572671
70NANOG_18555785_ChIP-Seq_MESCs_Mouse1.05197712
71KDM5A_27292631_Chip-Seq_BREAST_Human1.05112820
72IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.04136815
73BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04061575
74POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.00843056
75ELK1_22589737_ChIP-Seq_MCF10A_Human0.96336420
76FLI1_27457419_Chip-Seq_LIVER_Mouse0.94961509
77IGF1R_20145208_ChIP-Seq_DFB_Human0.92360952
78HTT_18923047_ChIP-ChIP_STHdh_Human0.92245237
79RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.89514958
80NANOG_16153702_ChIP-ChIP_HESCs_Human0.88975858
81PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.88821206
82EGR1_23403033_ChIP-Seq_LIVER_Mouse0.88766865
83TFEB_21752829_ChIP-Seq_HELA_Human0.88745141
84KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.87453279
85TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.86687517
86SOX17_20123909_ChIP-Seq_XEN_Mouse0.83438650
87ELF5_23300383_ChIP-Seq_T47D_Human0.82008517
88DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.81784582
89STAT3_1855785_ChIP-Seq_MESCs_Mouse0.80235348
90AR_20517297_ChIP-Seq_VCAP_Human0.79013926
91TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.78812105
92SALL1_21062744_ChIP-ChIP_HESCs_Human0.78457302
93PCGF2_27294783_Chip-Seq_ESCs_Mouse0.75247542
94ZNF263_19887448_ChIP-Seq_K562_Human0.75002978
95SOX2_18555785_ChIP-Seq_MESCs_Mouse0.73316327
96SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.72951884
97SOX2_16153702_ChIP-ChIP_HESCs_Human0.72611079
98NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.72174603
99NOTCH1_21737748_ChIP-Seq_TLL_Human0.72161016
100FOXA1_27270436_Chip-Seq_PROSTATE_Human0.71698063

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis5.03904908
2MP0010094_abnormal_chromosome_stability3.71411816
3MP0008058_abnormal_DNA_repair3.40949979
4MP0003693_abnormal_embryo_hatching3.12206988
5MP0004957_abnormal_blastocyst_morpholog3.08743674
6MP0008875_abnormal_xenobiotic_pharmacok3.02925188
7MP0002653_abnormal_ependyma_morphology2.63564332
8MP0006036_abnormal_mitochondrial_physio2.63148528
9MP0003186_abnormal_redox_activity2.52918356
10MP0003786_premature_aging2.51138605
11MP0003718_maternal_effect2.47545010
12MP0003111_abnormal_nucleus_morphology2.43098463
13MP0000372_irregular_coat_pigmentation2.39527082
14MP0003077_abnormal_cell_cycle2.32199234
15MP0002277_abnormal_respiratory_mucosa2.18215868
16MP0009697_abnormal_copulation2.17864136
17MP0002132_abnormal_respiratory_system2.17678457
18MP0008932_abnormal_embryonic_tissue2.13474198
19MP0008057_abnormal_DNA_replication2.12332590
20MP0008789_abnormal_olfactory_epithelium2.11636908
21MP0001529_abnormal_vocalization2.11346237
22MP0008007_abnormal_cellular_replicative2.10170183
23MP0006035_abnormal_mitochondrial_morpho2.06521648
24MP0002837_dystrophic_cardiac_calcinosis1.91614923
25MP0001984_abnormal_olfaction1.76176570
26MP0005408_hypopigmentation1.73555196
27MP0001764_abnormal_homeostasis1.70911797
28MP0009379_abnormal_foot_pigmentation1.64199569
29MP0006072_abnormal_retinal_apoptosis1.60823027
30MP0002160_abnormal_reproductive_system1.51462417
31MP0005084_abnormal_gallbladder_morpholo1.49172669
32MP0002102_abnormal_ear_morphology1.49155927
33MP0000358_abnormal_cell_content/1.42859017
34MP0008995_early_reproductive_senescence1.39975879
35MP0004133_heterotaxia1.38114733
36MP0003136_yellow_coat_color1.32676431
37MP0005645_abnormal_hypothalamus_physiol1.28806905
38MP0001929_abnormal_gametogenesis1.28075025
39MP0002736_abnormal_nociception_after1.25102434
40MP0005395_other_phenotype1.23927581
41MP0001293_anophthalmia1.22668190
42MP0002139_abnormal_hepatobiliary_system1.17219966
43MP0002163_abnormal_gland_morphology1.15441694
44MP0004215_abnormal_myocardial_fiber1.14680976
45MP0002210_abnormal_sex_determination1.13901543
46MP0002938_white_spotting1.12798999
47MP0003195_calcinosis1.12391486
48MP0005636_abnormal_mineral_homeostasis1.12061857
49MP0005499_abnormal_olfactory_system1.11151920
50MP0005394_taste/olfaction_phenotype1.11151920
51MP0005253_abnormal_eye_physiology1.09330445
52MP0004019_abnormal_vitamin_homeostasis1.01105533
53MP0005075_abnormal_melanosome_morpholog0.97082240
54MP0008873_increased_physiological_sensi0.96891135
55MP0002282_abnormal_trachea_morphology0.94680956
56MP0005646_abnormal_pituitary_gland0.94491363
57MP0000516_abnormal_urinary_system0.92710066
58MP0005367_renal/urinary_system_phenotyp0.92710066
59MP0000343_altered_response_to0.91970439
60MP0000350_abnormal_cell_proliferation0.91874214
61MP0000653_abnormal_sex_gland0.91464219
62MP0001727_abnormal_embryo_implantation0.89907267
63MP0002019_abnormal_tumor_incidence0.89223095
64MP0005389_reproductive_system_phenotype0.89172501
65MP0000313_abnormal_cell_death0.86986442
66MP0002090_abnormal_vision0.86812551
67MP0009333_abnormal_splenocyte_physiolog0.85187499
68MP0009046_muscle_twitch0.84311740
69MP0001145_abnormal_male_reproductive0.84258985
70MP0005165_increased_susceptibility_to0.83560482
71MP0002638_abnormal_pupillary_reflex0.83548754
72MP0008877_abnormal_DNA_methylation0.83125007
73MP0003698_abnormal_male_reproductive0.82371102
74MP0004043_abnormal_pH_regulation0.81189863
75MP0003941_abnormal_skin_development0.81135724
76MP0006292_abnormal_olfactory_placode0.80179838
77MP0010307_abnormal_tumor_latency0.79361839
78MP0005623_abnormal_meninges_morphology0.76794222
79MP0005332_abnormal_amino_acid0.76457892
80MP0005410_abnormal_fertilization0.75881404
81MP0002095_abnormal_skin_pigmentation0.75122309
82MP0001119_abnormal_female_reproductive0.74787799
83MP0005379_endocrine/exocrine_gland_phen0.73436266
84MP0001905_abnormal_dopamine_level0.72219618
85MP0000647_abnormal_sebaceous_gland0.70676305
86MP0001853_heart_inflammation0.69678809
87MP0000490_abnormal_crypts_of0.69504099
88MP0008872_abnormal_physiological_respon0.69399894
89MP0002909_abnormal_adrenal_gland0.68971292
90MP0002148_abnormal_hypersensitivity_rea0.66999710
91MP0001730_embryonic_growth_arrest0.66926379
92MP0006082_CNS_inflammation0.66896073
93MP0010678_abnormal_skin_adnexa0.66075536
94MP0001697_abnormal_embryo_size0.65999418
95MP0005187_abnormal_penis_morphology0.65620339
96MP0003123_paternal_imprinting0.65339704
97MP0002080_prenatal_lethality0.64905056
98MP0000631_abnormal_neuroendocrine_gland0.64314792
99MP0004147_increased_porphyrin_level0.63830256
100MP0003890_abnormal_embryonic-extraembry0.62795532

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.90799436
2Abnormal respiratory motile cilium physiology (HP:0012261)6.84666311
3Abnormal ciliary motility (HP:0012262)6.50652587
4Abnormal respiratory epithelium morphology (HP:0012253)6.48848437
5Abnormal respiratory motile cilium morphology (HP:0005938)6.48848437
6Dynein arm defect of respiratory motile cilia (HP:0012255)6.39955449
7Absent/shortened dynein arms (HP:0200106)6.39955449
8Rhinitis (HP:0012384)6.20783926
9Chronic bronchitis (HP:0004469)4.92261077
10Bronchiectasis (HP:0002110)4.37021139
11Acute necrotizing encephalopathy (HP:0006965)4.12398928
12Increased hepatocellular lipid droplets (HP:0006565)4.09897087
13Mitochondrial inheritance (HP:0001427)3.84599409
14Abnormal mitochondria in muscle tissue (HP:0008316)3.75933836
15Lipid accumulation in hepatocytes (HP:0006561)3.74698849
16Increased CSF lactate (HP:0002490)3.62305061
17Acute encephalopathy (HP:0006846)3.59216710
18Progressive macrocephaly (HP:0004481)3.54907099
19Renal Fanconi syndrome (HP:0001994)3.52983351
20True hermaphroditism (HP:0010459)3.51378853
21Pancreatic fibrosis (HP:0100732)3.50636929
22Nasal polyposis (HP:0100582)3.25476567
23Hepatocellular necrosis (HP:0001404)3.23450833
24Pancreatic cysts (HP:0001737)3.18499433
25Hepatic necrosis (HP:0002605)3.14454084
26Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.88921651
27Decreased activity of mitochondrial respiratory chain (HP:0008972)2.88921651
28Cerebral edema (HP:0002181)2.85876790
29Abnormality of midbrain morphology (HP:0002418)2.79616676
30Molar tooth sign on MRI (HP:0002419)2.79616676
31Chronic sinusitis (HP:0011109)2.77626033
32Increased intramyocellular lipid droplets (HP:0012240)2.69670174
333-Methylglutaconic aciduria (HP:0003535)2.66510477
34Bronchitis (HP:0012387)2.66292481
35Exertional dyspnea (HP:0002875)2.65929507
36Occipital encephalocele (HP:0002085)2.57900240
37Recurrent sinusitis (HP:0011108)2.53024654
38Abnormality of the nasal mucosa (HP:0000433)2.51461746
39Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.46245822
40Nephronophthisis (HP:0000090)2.41604389
41Exercise intolerance (HP:0003546)2.40295866
42Lactic acidosis (HP:0003128)2.39995270
43Respiratory failure (HP:0002878)2.39698538
44Increased serum lactate (HP:0002151)2.38442180
45Medial flaring of the eyebrow (HP:0010747)2.33082180
46Abnormality of renal resorption (HP:0011038)2.23394399
47Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.21471470
48Infertility (HP:0000789)2.17691450
49Degeneration of anterior horn cells (HP:0002398)2.17371550
50Abnormality of the anterior horn cell (HP:0006802)2.17371550
51Increased muscle lipid content (HP:0009058)2.16210641
52Postaxial foot polydactyly (HP:0001830)2.16105660
53Aplasia/Hypoplasia of the tongue (HP:0010295)2.15582437
54Sclerocornea (HP:0000647)2.09692600
55Male pseudohermaphroditism (HP:0000037)2.06146966
56Respiratory difficulties (HP:0002880)2.03753943
57Increased serum pyruvate (HP:0003542)2.01700112
58Cystic liver disease (HP:0006706)1.96849936
59Recurrent otitis media (HP:0000403)1.96629448
60Chronic hepatic failure (HP:0100626)1.95544654
61Congenital primary aphakia (HP:0007707)1.93700560
62Methylmalonic acidemia (HP:0002912)1.93545345
63Anencephaly (HP:0002323)1.92657753
64Congenital hepatic fibrosis (HP:0002612)1.91815175
65Lethargy (HP:0001254)1.90692269
66Median cleft lip (HP:0000161)1.90266130
67Supernumerary spleens (HP:0009799)1.85534766
68Optic disc pallor (HP:0000543)1.84659179
69Aplastic anemia (HP:0001915)1.82880407
70Type I transferrin isoform profile (HP:0003642)1.81948952
71Abnormality of methionine metabolism (HP:0010901)1.81772389
72CNS demyelination (HP:0007305)1.81322972
73Hypoglycemic coma (HP:0001325)1.80839801
74Furrowed tongue (HP:0000221)1.78629524
75Generalized aminoaciduria (HP:0002909)1.78450489
76Abnormal protein glycosylation (HP:0012346)1.78179920
77Abnormal glycosylation (HP:0012345)1.78179920
78Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.78179920
79Abnormal protein N-linked glycosylation (HP:0012347)1.78179920
80Gait imbalance (HP:0002141)1.77897975
81Abnormality of urine glucose concentration (HP:0011016)1.77194451
82Glycosuria (HP:0003076)1.77194451
83Abnormality of the renal medulla (HP:0100957)1.75837570
84Chronic otitis media (HP:0000389)1.74615110
85Oculomotor apraxia (HP:0000657)1.71400224
86Nephrogenic diabetes insipidus (HP:0009806)1.70968037
87Male infertility (HP:0003251)1.69444842
88Aplasia/Hypoplasia of the sacrum (HP:0008517)1.69323042
89Leukodystrophy (HP:0002415)1.69041331
90Abnormality of glycolysis (HP:0004366)1.65087075
91Abnormality of alanine metabolism (HP:0010916)1.64360072
92Hyperalaninemia (HP:0003348)1.64360072
93Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.64360072
94Congenital, generalized hypertrichosis (HP:0004540)1.59855586
95Postaxial hand polydactyly (HP:0001162)1.59241533
96Abnormal number of erythroid precursors (HP:0012131)1.58498490
97Pancytopenia (HP:0001876)1.58039811
98Reduced antithrombin III activity (HP:0001976)1.57920875
99Methylmalonic aciduria (HP:0012120)1.57592270
100Abnormality of the renal cortex (HP:0011035)1.55705456

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST44.00911729
2VRK23.77577819
3BUB13.48728267
4EIF2AK12.94796421
5EIF2AK32.79316076
6PBK2.69702692
7NEK12.68292535
8VRK12.47367356
9WEE12.37290413
10SRPK12.31649254
11MAPK152.22932976
12NME22.06619431
13TTK2.06545524
14CDC72.04110093
15PLK41.96119333
16STK161.94884180
17TESK11.92081102
18CCNB11.90616035
19ZAK1.84742186
20TSSK61.81884066
21BRSK21.77936081
22PLK31.74504578
23NUAK11.72211935
24MAP4K21.64335365
25MAP3K121.60657180
26BCR1.52099566
27PNCK1.51404068
28SCYL21.44794384
29ERBB31.43754450
30NME11.40723644
31TAF11.39746607
32WNK31.38682585
33MKNK11.36561479
34TRIM281.35899722
35PLK11.24147485
36BCKDK1.16375643
37MKNK21.12514380
38DYRK31.11838219
39ACVR1B1.10974696
40STK41.07195371
41RPS6KA41.05436231
42CSNK1G21.05233499
43FRK1.04462038
44TLK11.02555916
45CSNK1G31.02215396
46AURKB0.99227768
47BMPR1B0.96331680
48MAP2K70.94920390
49PIM20.88618318
50PDK20.86494580
51CSNK1G10.85601630
52ATR0.79325853
53AURKA0.75786485
54RPS6KA50.73528787
55LIMK10.71521235
56STK240.70394551
57PLK20.69735063
58DYRK20.68662312
59MAP3K40.67800988
60EPHA20.67061383
61KDR0.66944021
62EIF2AK20.62557077
63BRSK10.62092384
64GRK10.61295616
65CHEK20.61081005
66CSNK2A10.58244794
67STK30.57713774
68DAPK10.56973067
69CSNK1A1L0.56292620
70CSNK2A20.54887004
71ADRBK20.54109030
72OXSR10.51335388
73BMPR20.51063428
74STK390.50866133
75STK100.49962986
76EPHA30.49515766
77STK38L0.47896573
78PRKCI0.47305088
79MAP3K80.45273555
80ERBB40.45034580
81PAK40.44300182
82PASK0.43726710
83ARAF0.42126068
84MAPKAPK30.41542705
85CLK10.41434242
86MINK10.41121720
87ATM0.39999924
88ABL20.39962112
89MYLK0.38139938
90ILK0.36719548
91CHEK10.35375537
92TAOK10.29781170
93LRRK20.29426351
94TESK20.28090543
95TEC0.27933456
96WNK40.25559946
97PTK2B0.25294203
98CSNK1A10.23724977
99FER0.23052947
100PAK10.22770807

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.50345024
2Oxidative phosphorylation_Homo sapiens_hsa001903.78815760
3Mismatch repair_Homo sapiens_hsa034303.22576485
4Parkinsons disease_Homo sapiens_hsa050123.17523446
5Protein export_Homo sapiens_hsa030603.01475613
6DNA replication_Homo sapiens_hsa030302.94244897
7Huntingtons disease_Homo sapiens_hsa050162.80355408
8Ribosome_Homo sapiens_hsa030102.62505038
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.28533900
10RNA polymerase_Homo sapiens_hsa030202.25361069
11Homologous recombination_Homo sapiens_hsa034402.18013284
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.09246108
13Alzheimers disease_Homo sapiens_hsa050101.95824300
14Nucleotide excision repair_Homo sapiens_hsa034201.95367502
15Spliceosome_Homo sapiens_hsa030401.90057310
16Non-homologous end-joining_Homo sapiens_hsa034501.83965794
17Pyrimidine metabolism_Homo sapiens_hsa002401.75751097
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.74449560
19Fanconi anemia pathway_Homo sapiens_hsa034601.74336956
20Glutathione metabolism_Homo sapiens_hsa004801.71694154
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.68587971
22RNA transport_Homo sapiens_hsa030131.62042021
23Base excision repair_Homo sapiens_hsa034101.61383046
24Propanoate metabolism_Homo sapiens_hsa006401.53488068
25Fatty acid elongation_Homo sapiens_hsa000621.44947795
26Basal transcription factors_Homo sapiens_hsa030221.43425937
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.42650069
28Pyruvate metabolism_Homo sapiens_hsa006201.36305901
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.36145919
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.35733114
31One carbon pool by folate_Homo sapiens_hsa006701.34841884
32RNA degradation_Homo sapiens_hsa030181.31906945
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.31042109
34Steroid biosynthesis_Homo sapiens_hsa001001.30191222
35Collecting duct acid secretion_Homo sapiens_hsa049661.26710290
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.24315352
37Folate biosynthesis_Homo sapiens_hsa007901.23849455
38Purine metabolism_Homo sapiens_hsa002301.22297505
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.15710233
40Peroxisome_Homo sapiens_hsa041461.11581092
41Cardiac muscle contraction_Homo sapiens_hsa042601.05537181
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.04191069
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.02009665
44Chemical carcinogenesis_Homo sapiens_hsa052041.01143921
45Cell cycle_Homo sapiens_hsa041101.00482446
46Butanoate metabolism_Homo sapiens_hsa006500.95815145
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.93945134
48Sulfur metabolism_Homo sapiens_hsa009200.90905174
49Systemic lupus erythematosus_Homo sapiens_hsa053220.89924390
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89593343
51Tyrosine metabolism_Homo sapiens_hsa003500.88360332
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.87970081
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87918623
54Metabolic pathways_Homo sapiens_hsa011000.83753169
55beta-Alanine metabolism_Homo sapiens_hsa004100.83120125
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79902877
57Caffeine metabolism_Homo sapiens_hsa002320.79218918
58Phenylalanine metabolism_Homo sapiens_hsa003600.76696112
59Carbon metabolism_Homo sapiens_hsa012000.71374149
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70981189
61Selenocompound metabolism_Homo sapiens_hsa004500.70156417
62Vitamin B6 metabolism_Homo sapiens_hsa007500.69856761
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67815967
64Fatty acid degradation_Homo sapiens_hsa000710.64823928
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.63181270
66Antigen processing and presentation_Homo sapiens_hsa046120.58410043
67Drug metabolism - other enzymes_Homo sapiens_hsa009830.58120873
68p53 signaling pathway_Homo sapiens_hsa041150.55206441
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.54814060
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54738310
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50862202
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50328082
73Oocyte meiosis_Homo sapiens_hsa041140.49959078
74Type I diabetes mellitus_Homo sapiens_hsa049400.48561366
75Primary immunodeficiency_Homo sapiens_hsa053400.48495504
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48025876
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46916203
78Fatty acid metabolism_Homo sapiens_hsa012120.46066658
79N-Glycan biosynthesis_Homo sapiens_hsa005100.45614898
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45454376
81Rheumatoid arthritis_Homo sapiens_hsa053230.44046114
82Retinol metabolism_Homo sapiens_hsa008300.44011838
83Vibrio cholerae infection_Homo sapiens_hsa051100.43935420
84Histidine metabolism_Homo sapiens_hsa003400.43657526
85mRNA surveillance pathway_Homo sapiens_hsa030150.43569276
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42385615
87Epstein-Barr virus infection_Homo sapiens_hsa051690.39221709
88Regulation of autophagy_Homo sapiens_hsa041400.39001676
89Biosynthesis of amino acids_Homo sapiens_hsa012300.37803927
90Alcoholism_Homo sapiens_hsa050340.36712576
91Asthma_Homo sapiens_hsa053100.34497069
92Sphingolipid metabolism_Homo sapiens_hsa006000.32736049
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30794017
94Tryptophan metabolism_Homo sapiens_hsa003800.30631740
95Sulfur relay system_Homo sapiens_hsa041220.27955399
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.27917852
97Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.24625585
98Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.23678800
99Arginine and proline metabolism_Homo sapiens_hsa003300.22927786
100Pentose phosphate pathway_Homo sapiens_hsa000300.21035857

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »