C14ORF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.78237162
2ATP synthesis coupled proton transport (GO:0015986)4.95298982
3energy coupled proton transport, down electrochemical gradient (GO:0015985)4.95298982
4chaperone-mediated protein transport (GO:0072321)4.77489843
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.60542582
6establishment of protein localization to mitochondrial membrane (GO:0090151)4.60177844
7protein complex biogenesis (GO:0070271)4.23652153
8respiratory electron transport chain (GO:0022904)4.18796039
9proteasome assembly (GO:0043248)4.16707846
10electron transport chain (GO:0022900)4.13566840
11regulation of mitochondrial translation (GO:0070129)4.04246652
12mitochondrial respiratory chain complex assembly (GO:0033108)4.01696173
13mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.89417871
14mitochondrial respiratory chain complex I assembly (GO:0032981)3.89417871
15NADH dehydrogenase complex assembly (GO:0010257)3.89417871
16water-soluble vitamin biosynthetic process (GO:0042364)3.81757780
17cholesterol biosynthetic process (GO:0006695)3.70651028
18respiratory chain complex IV assembly (GO:0008535)3.68659803
19protein neddylation (GO:0045116)3.68626535
20termination of RNA polymerase III transcription (GO:0006386)3.60752825
21transcription elongation from RNA polymerase III promoter (GO:0006385)3.60752825
22cullin deneddylation (GO:0010388)3.49980709
23establishment of integrated proviral latency (GO:0075713)3.47451019
24negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.35999073
25protein deneddylation (GO:0000338)3.34998334
26* sterol biosynthetic process (GO:0016126)3.34679832
27cytochrome complex assembly (GO:0017004)3.32301719
28L-serine metabolic process (GO:0006563)3.24613069
29regulation of cellular amino acid metabolic process (GO:0006521)3.19053238
30regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.10869206
31aldehyde catabolic process (GO:0046185)3.09546227
32positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.07864508
33tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.07100417
34RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.07100417
35nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.05669840
36negative regulation of ligase activity (GO:0051352)3.02972231
37negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.02972231
38inner mitochondrial membrane organization (GO:0007007)3.02176376
39exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.97916274
40glyoxylate metabolic process (GO:0046487)2.97120562
41L-phenylalanine catabolic process (GO:0006559)2.96815149
42erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.96815149
43chromatin remodeling at centromere (GO:0031055)2.94412462
44ribosomal small subunit assembly (GO:0000028)2.93315959
45DNA damage response, detection of DNA damage (GO:0042769)2.92285563
46isoprenoid biosynthetic process (GO:0008299)2.89133188
47anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.87733523
48branched-chain amino acid catabolic process (GO:0009083)2.86666089
49ATP biosynthetic process (GO:0006754)2.86307561
50CENP-A containing nucleosome assembly (GO:0034080)2.85394996
51purine nucleoside triphosphate biosynthetic process (GO:0009145)2.83346525
52oxidative phosphorylation (GO:0006119)2.82939095
53purine nucleobase biosynthetic process (GO:0009113)2.80983199
54protein targeting to mitochondrion (GO:0006626)2.80382694
55pseudouridine synthesis (GO:0001522)2.80155072
56rRNA modification (GO:0000154)2.79584911
57ribosomal large subunit biogenesis (GO:0042273)2.79057245
58DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.77881645
59protein-cofactor linkage (GO:0018065)2.76347592
60purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.76061830
61hydrogen ion transmembrane transport (GO:1902600)2.74223378
62establishment of protein localization to mitochondrion (GO:0072655)2.73671267
63signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.72654048
64signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.72654048
65signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.72654048
66protein localization to mitochondrion (GO:0070585)2.71875192
67serine family amino acid biosynthetic process (GO:0009070)2.71299358
68establishment of viral latency (GO:0019043)2.70959453
69cotranslational protein targeting to membrane (GO:0006613)2.70589921
70intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.69684146
71signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.69684146
72SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.68889737
73spliceosomal snRNP assembly (GO:0000387)2.66363560
74erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.65760688
75L-phenylalanine metabolic process (GO:0006558)2.65760688
76maturation of SSU-rRNA (GO:0030490)2.65044469
77intracellular protein transmembrane import (GO:0044743)2.64926277
78protein targeting to ER (GO:0045047)2.63808280
79translation (GO:0006412)2.63590874
80signal transduction involved in DNA integrity checkpoint (GO:0072401)2.60454833
81signal transduction involved in DNA damage checkpoint (GO:0072422)2.60454833
82positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.59706928
83signal transduction involved in cell cycle checkpoint (GO:0072395)2.59482031
84glycine metabolic process (GO:0006544)2.57459771
85peptidyl-histidine modification (GO:0018202)2.57288626
86nucleobase biosynthetic process (GO:0046112)2.55177140
87protein localization to endoplasmic reticulum (GO:0070972)2.52516844
88ribonucleoside triphosphate biosynthetic process (GO:0009201)2.52501458
897-methylguanosine mRNA capping (GO:0006370)2.51924115
90establishment of protein localization to endoplasmic reticulum (GO:0072599)2.51709133
91mannosylation (GO:0097502)2.50784052
92serine family amino acid catabolic process (GO:0009071)2.50480636
93proton transport (GO:0015992)2.49473189
94regulation of cellular amine metabolic process (GO:0033238)2.49037995
95hydrogen transport (GO:0006818)2.45369069
96RNA capping (GO:0036260)2.44651267
977-methylguanosine RNA capping (GO:0009452)2.44651267
98serine family amino acid metabolic process (GO:0009069)2.44473031
99GTP biosynthetic process (GO:0006183)2.43617015
100cellular component biogenesis (GO:0044085)2.43591291

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.86805643
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.29994390
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.22171446
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.82649751
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.18970414
6* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.06253773
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.03829249
8* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.98608458
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.84026351
10CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.78753643
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.76551911
12ELK1_19687146_ChIP-ChIP_HELA_Human2.44584088
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.33214536
14PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.27468786
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.18359866
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.13674464
17SRF_21415370_ChIP-Seq_HL-1_Mouse2.07738625
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.03935902
19VDR_23849224_ChIP-Seq_CD4+_Human2.03555219
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.02058927
21FOXP3_21729870_ChIP-Seq_TREG_Human1.97427739
22E2F1_18555785_ChIP-Seq_MESCs_Mouse1.95882090
23THAP11_20581084_ChIP-Seq_MESCs_Mouse1.94530558
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.88541456
25ZNF274_21170338_ChIP-Seq_K562_Hela1.86570418
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.83416354
27MYC_19079543_ChIP-ChIP_MESCs_Mouse1.81572129
28DCP1A_22483619_ChIP-Seq_HELA_Human1.79432284
29EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.78582314
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78151965
31GABP_19822575_ChIP-Seq_HepG2_Human1.76760513
32ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.75033345
33TTF2_22483619_ChIP-Seq_HELA_Human1.73758090
34MYC_18940864_ChIP-ChIP_HL60_Human1.70701802
35PADI4_21655091_ChIP-ChIP_MCF-7_Human1.69093377
36CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.67851913
37E2F7_22180533_ChIP-Seq_HELA_Human1.67834085
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.67292471
39XRN2_22483619_ChIP-Seq_HELA_Human1.63075985
40VDR_22108803_ChIP-Seq_LS180_Human1.60724205
41YY1_21170310_ChIP-Seq_MESCs_Mouse1.60359655
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.58231501
43FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.57275079
44FUS_26573619_Chip-Seq_HEK293_Human1.53525679
45RBPJ_22232070_ChIP-Seq_NCS_Mouse1.52931703
46HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.52398234
47EWS_26573619_Chip-Seq_HEK293_Human1.52122848
48POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.45164122
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45151381
50NANOG_16153702_ChIP-ChIP_HESCs_Human1.38682013
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.38106640
52POU5F1_16153702_ChIP-ChIP_HESCs_Human1.29629295
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.25506819
54MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.25118858
55MYCN_18555785_ChIP-Seq_MESCs_Mouse1.24707413
56SOX2_16153702_ChIP-ChIP_HESCs_Human1.22436155
57IGF1R_20145208_ChIP-Seq_DFB_Human1.22159225
58DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.21204326
59POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.20326417
60ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.19888406
61GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.18681883
62CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.17247632
63TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10894626
64NANOG_18555785_ChIP-Seq_MESCs_Mouse1.09023553
65SOX2_18555785_ChIP-Seq_MESCs_Mouse1.07088615
66ELK1_22589737_ChIP-Seq_MCF10A_Human1.06549381
67AR_21909140_ChIP-Seq_LNCAP_Human1.05595356
68SALL1_21062744_ChIP-ChIP_HESCs_Human1.03820401
69P300_19829295_ChIP-Seq_ESCs_Human1.03618806
70CTBP1_25329375_ChIP-Seq_LNCAP_Human1.02719516
71TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02277737
72ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.01992594
73POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00420028
74HTT_18923047_ChIP-ChIP_STHdh_Human0.98642672
75SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.98543892
76FLI1_27457419_Chip-Seq_LIVER_Mouse0.96184739
77FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95628362
78ZFP57_27257070_Chip-Seq_ESCs_Mouse0.95063416
79CTBP2_25329375_ChIP-Seq_LNCAP_Human0.94674338
80TAF15_26573619_Chip-Seq_HEK293_Human0.94250727
81IRF1_19129219_ChIP-ChIP_H3396_Human0.92452308
82GBX2_23144817_ChIP-Seq_PC3_Human0.92137215
83SOX17_20123909_ChIP-Seq_XEN_Mouse0.91799730
84E2F1_21310950_ChIP-Seq_MCF-7_Human0.91128781
85POU3F2_20337985_ChIP-ChIP_501MEL_Human0.90986112
86KDM5A_27292631_Chip-Seq_BREAST_Human0.90599286
87MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.89246483
88ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.89028127
89GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89008305
90ZFX_18555785_ChIP-Seq_MESCs_Mouse0.88511826
91GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.85782937
92CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.85310971
93NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.84584126
94CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.84464938
95KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.84093033
96TP53_22573176_ChIP-Seq_HFKS_Human0.82198756
97EGR1_23403033_ChIP-Seq_LIVER_Mouse0.81590426
98MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.81545526
99CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.81129040
100* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.80933037

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode2.75189657
2MP0003122_maternal_imprinting2.74867653
3MP0001529_abnormal_vocalization2.68564510
4MP0008058_abnormal_DNA_repair2.47098953
5MP0002938_white_spotting2.43227668
6MP0008877_abnormal_DNA_methylation2.33247992
7MP0003011_delayed_dark_adaptation2.26128378
8MP0008875_abnormal_xenobiotic_pharmacok2.19333360
9MP0008789_abnormal_olfactory_epithelium2.14953003
10MP0002139_abnormal_hepatobiliary_system2.14920020
11MP0001984_abnormal_olfaction2.06521356
12MP0003718_maternal_effect2.00673529
13MP0000566_synostosis1.93464124
14MP0003195_calcinosis1.92983087
15MP0003890_abnormal_embryonic-extraembry1.92748660
16MP0003693_abnormal_embryo_hatching1.81684796
17MP0003186_abnormal_redox_activity1.79420671
18MP0005084_abnormal_gallbladder_morpholo1.78281948
19MP0003121_genomic_imprinting1.78251898
20MP0005499_abnormal_olfactory_system1.77230795
21MP0005394_taste/olfaction_phenotype1.77230795
22MP0009379_abnormal_foot_pigmentation1.76542293
23MP0006072_abnormal_retinal_apoptosis1.73913901
24MP0001293_anophthalmia1.73614492
25MP0009697_abnormal_copulation1.66936110
26MP0004133_heterotaxia1.64066451
27MP0004957_abnormal_blastocyst_morpholog1.59338564
28MP0010030_abnormal_orbit_morphology1.58400381
29MP0003880_abnormal_central_pattern1.55477334
30MP0005085_abnormal_gallbladder_physiolo1.54203198
31MP0003806_abnormal_nucleotide_metabolis1.53866274
32MP0002736_abnormal_nociception_after1.52151549
33MP0003941_abnormal_skin_development1.49193011
34MP0002653_abnormal_ependyma_morphology1.48938605
35MP0005365_abnormal_bile_salt1.42569588
36MP0006035_abnormal_mitochondrial_morpho1.41052223
37MP0003136_yellow_coat_color1.38113043
38MP0008932_abnormal_embryonic_tissue1.37561410
39MP0010094_abnormal_chromosome_stability1.37424116
40MP0005408_hypopigmentation1.34332437
41MP0003787_abnormal_imprinting1.26498889
42MP0004147_increased_porphyrin_level1.25724638
43MP0005332_abnormal_amino_acid1.23912082
44MP0002233_abnormal_nose_morphology1.23701047
45MP0000372_irregular_coat_pigmentation1.23381240
46MP0003123_paternal_imprinting1.23256235
47MP0005551_abnormal_eye_electrophysiolog1.22860888
48MP0006036_abnormal_mitochondrial_physio1.20994087
49MP0002102_abnormal_ear_morphology1.20518380
50MP0003567_abnormal_fetal_cardiomyocyte1.19593673
51MP0004142_abnormal_muscle_tone1.19431477
52MP0009046_muscle_twitch1.17530002
53MP0003937_abnormal_limbs/digits/tail_de1.17060750
54MP0001764_abnormal_homeostasis1.16321257
55MP0003111_abnormal_nucleus_morphology1.15505113
56MP0003786_premature_aging1.11491863
57MP0001188_hyperpigmentation1.08569249
58MP0003119_abnormal_digestive_system1.07597537
59MP0005253_abnormal_eye_physiology1.06130160
60MP0001666_abnormal_nutrient_absorption1.04322248
61MP0002090_abnormal_vision1.03109337
62MP0001968_abnormal_touch/_nociception1.03062112
63MP0000049_abnormal_middle_ear1.01294057
64MP0002272_abnormal_nervous_system1.01244862
65MP0003315_abnormal_perineum_morphology0.99559556
66MP0008007_abnormal_cellular_replicative0.99077828
67MP0002638_abnormal_pupillary_reflex0.98949988
68MP0001485_abnormal_pinna_reflex0.98892861
69MP0004019_abnormal_vitamin_homeostasis0.97966185
70MP0000631_abnormal_neuroendocrine_gland0.96956856
71MP0001905_abnormal_dopamine_level0.95853465
72MP0001286_abnormal_eye_development0.94891355
73MP0006276_abnormal_autonomic_nervous0.93477116
74MP0005646_abnormal_pituitary_gland0.92977179
75MP0002234_abnormal_pharynx_morphology0.92233204
76MP0008995_early_reproductive_senescence0.90329824
77MP0008872_abnormal_physiological_respon0.87984190
78MP0000647_abnormal_sebaceous_gland0.87590049
79MP0002160_abnormal_reproductive_system0.87334820
80MP0010329_abnormal_lipoprotein_level0.86104255
81MP0002751_abnormal_autonomic_nervous0.85648285
82MP0003077_abnormal_cell_cycle0.85527228
83MP0002210_abnormal_sex_determination0.85338114
84MP0005645_abnormal_hypothalamus_physiol0.84992245
85MP0002697_abnormal_eye_size0.83107595
86MP0002557_abnormal_social/conspecific_i0.79818264
87MP0009745_abnormal_behavioral_response0.79160906
88MP0001929_abnormal_gametogenesis0.79120001
89MP0000778_abnormal_nervous_system0.78494000
90MP0003755_abnormal_palate_morphology0.78444902
91MP0002876_abnormal_thyroid_physiology0.78071319
92MP0005391_vision/eye_phenotype0.77234951
93MP0005389_reproductive_system_phenotype0.76945538
94MP0000653_abnormal_sex_gland0.76169613
95MP0001145_abnormal_male_reproductive0.74207430
96MP0002277_abnormal_respiratory_mucosa0.74042905
97MP0002837_dystrophic_cardiac_calcinosis0.72464504
98MP0004742_abnormal_vestibular_system0.72408811
99MP0002184_abnormal_innervation0.72337324
100MP0002282_abnormal_trachea_morphology0.72135655

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.73473502
2Acute encephalopathy (HP:0006846)4.42300851
3Abnormal mitochondria in muscle tissue (HP:0008316)4.29638894
4Mitochondrial inheritance (HP:0001427)4.00951117
5Progressive macrocephaly (HP:0004481)3.87415236
6Increased CSF lactate (HP:0002490)3.64657860
7Increased hepatocellular lipid droplets (HP:0006565)3.50525115
8Hyperglycinemia (HP:0002154)3.42046976
9Cerebral edema (HP:0002181)3.38745218
10Hepatocellular necrosis (HP:0001404)3.32162955
11Lipid accumulation in hepatocytes (HP:0006561)3.24806666
12Hepatic necrosis (HP:0002605)3.14009416
13Renal Fanconi syndrome (HP:0001994)3.07423930
14Increased serum pyruvate (HP:0003542)3.06524070
15Abnormality of the labia minora (HP:0012880)3.01668227
16Methylmalonic acidemia (HP:0002912)2.89722526
17Abnormality of glycolysis (HP:0004366)2.74170831
18Type I transferrin isoform profile (HP:0003642)2.73743858
19Abnormality of glycine metabolism (HP:0010895)2.66064990
20Abnormality of serine family amino acid metabolism (HP:0010894)2.66064990
21Hyperglycinuria (HP:0003108)2.61048097
22True hermaphroditism (HP:0010459)2.60394186
23Abnormality of methionine metabolism (HP:0010901)2.58218751
24Abnormality of aromatic amino acid family metabolism (HP:0004338)2.54467177
25Pancreatic fibrosis (HP:0100732)2.52465174
26Lactic acidosis (HP:0003128)2.50372581
27Methylmalonic aciduria (HP:0012120)2.48788291
28Increased serum lactate (HP:0002151)2.48204977
29Decreased activity of mitochondrial respiratory chain (HP:0008972)2.47889946
30Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.47889946
31Lethargy (HP:0001254)2.44735271
32Abnormality of serum amino acid levels (HP:0003112)2.43609554
33Medial flaring of the eyebrow (HP:0010747)2.42754965
34Septo-optic dysplasia (HP:0100842)2.42528811
35Respiratory failure (HP:0002878)2.39137870
363-Methylglutaconic aciduria (HP:0003535)2.35398114
37Pancreatic cysts (HP:0001737)2.33733492
38Colon cancer (HP:0003003)2.27752577
39Leukodystrophy (HP:0002415)2.24982855
40Reduced antithrombin III activity (HP:0001976)2.24616202
41Abnormality of aspartate family amino acid metabolism (HP:0010899)2.24469872
42Abnormal protein glycosylation (HP:0012346)2.22376938
43Abnormal glycosylation (HP:0012345)2.22376938
44Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.22376938
45Abnormal protein N-linked glycosylation (HP:0012347)2.22376938
46Optic disc pallor (HP:0000543)2.20910630
47Abnormal number of erythroid precursors (HP:0012131)2.18280261
48Hyperphosphaturia (HP:0003109)2.16717227
49Macrocytic anemia (HP:0001972)2.13631257
50Poor suck (HP:0002033)2.11649642
51Increased intramyocellular lipid droplets (HP:0012240)2.11376084
52Abnormality of urine glucose concentration (HP:0011016)2.11021536
53Glycosuria (HP:0003076)2.11021536
54Reticulocytopenia (HP:0001896)2.05116423
55Congenital primary aphakia (HP:0007707)2.04192160
56Abnormality of cells of the erythroid lineage (HP:0012130)2.04074989
57Exercise intolerance (HP:0003546)2.02794019
58Prolonged partial thromboplastin time (HP:0003645)2.02035170
59Bifid tongue (HP:0010297)2.01766052
60Molar tooth sign on MRI (HP:0002419)2.00985806
61Abnormality of midbrain morphology (HP:0002418)2.00985806
62Sclerocornea (HP:0000647)2.00905665
63Gait imbalance (HP:0002141)1.99776479
64Hypoglycemic coma (HP:0001325)1.99174496
65Abnormal lung lobation (HP:0002101)1.98869285
66Myokymia (HP:0002411)1.94398923
67Nephrogenic diabetes insipidus (HP:0009806)1.94267658
68Abnormality of renal resorption (HP:0011038)1.92695333
69Aplasia/Hypoplasia of the tongue (HP:0010295)1.92640991
70Genital tract atresia (HP:0001827)1.91823644
71Vaginal atresia (HP:0000148)1.90515100
72Supernumerary spleens (HP:0009799)1.89116796
73Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.87594923
74Hypoplastic pelvis (HP:0008839)1.86632857
75Anophthalmia (HP:0000528)1.86468613
76Meckel diverticulum (HP:0002245)1.84309694
77Nephronophthisis (HP:0000090)1.83354541
78Abnormality of the anterior horn cell (HP:0006802)1.80027316
79Degeneration of anterior horn cells (HP:0002398)1.80027316
80Male pseudohermaphroditism (HP:0000037)1.77894173
81X-linked dominant inheritance (HP:0001423)1.75582253
82Abnormality of the ileum (HP:0001549)1.75490686
83Exertional dyspnea (HP:0002875)1.75298574
84CNS demyelination (HP:0007305)1.72247739
85Abnormal biliary tract physiology (HP:0012439)1.71833867
86Bile duct proliferation (HP:0001408)1.71833867
87Neoplasm of the adrenal gland (HP:0100631)1.71420536
88Absent septum pellucidum (HP:0001331)1.70360771
89Delayed CNS myelination (HP:0002188)1.70155627
90Hyperinsulinemic hypoglycemia (HP:0000825)1.69405976
91Abnormality of vitamin B metabolism (HP:0004340)1.69228370
92Stenosis of the external auditory canal (HP:0000402)1.68700655
93Hypobetalipoproteinemia (HP:0003563)1.68380106
94Sparse eyelashes (HP:0000653)1.65815196
95Postaxial hand polydactyly (HP:0001162)1.64933838
96Adrenal hypoplasia (HP:0000835)1.64782528
97Generalized aminoaciduria (HP:0002909)1.63706388
98Increased muscle lipid content (HP:0009058)1.63530300
99Bilateral microphthalmos (HP:0007633)1.63501532
100Microvesicular hepatic steatosis (HP:0001414)1.62579145

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.96024327
2STK162.90612648
3MST42.82862080
4BUB12.70544486
5SRPK12.44348413
6TSSK62.35973859
7WNK32.33956906
8CDC72.22505508
9VRK12.19548184
10PBK2.18122256
11EIF2AK12.17641486
12MAP3K122.10060153
13BCKDK2.09564766
14ZAK2.03473843
15MAP4K21.98860346
16PLK31.93170530
17BMPR1B1.88094822
18TRIM281.87982246
19TNIK1.84372147
20DYRK21.83563413
21NME11.82329839
22PNCK1.76116896
23EIF2AK31.75120437
24NUAK11.70760609
25NEK11.70663956
26WEE11.57616822
27TTK1.55559421
28PLK41.55240737
29CSNK1G11.49809626
30MKNK21.49419659
31CASK1.45056022
32TAF11.39145375
33MKNK11.38971275
34CSNK1G31.38128273
35MAP3K41.32654607
36CSNK1G21.28176681
37PLK11.23327029
38MAP2K71.20879610
39BCR1.19892054
40BRSK21.17734420
41GRK11.13669168
42CSNK1A1L1.09444376
43PINK11.06483988
44CDK191.02571792
45PLK20.99680993
46PRKCG0.93342259
47WNK40.89681931
48ADRBK20.89226208
49LIMK10.86154925
50EPHA40.84248664
51BRSK10.83819953
52DYRK30.82977272
53OXSR10.82780669
54MAPK150.79658532
55FGFR20.78392040
56FRK0.77510742
57NME20.77375846
58ACVR1B0.73178878
59PASK0.73011597
60AURKB0.69868613
61TIE10.69227289
62ATR0.69078016
63STK390.68226015
64MINK10.64599741
65PRKCE0.62469614
66CSNK2A20.61192661
67TLK10.60967583
68CSNK2A10.60518991
69CHEK20.59304224
70CSNK1A10.58159021
71DAPK10.56261397
72TESK10.55764200
73AURKA0.54923135
74ERBB30.54798411
75PDK20.53995819
76CSNK1E0.53856398
77TGFBR10.52230561
78PRKCI0.52064917
79FGFR10.49623167
80ATM0.49202713
81EIF2AK20.47646237
82EPHA20.47470380
83MAPKAPK50.45801686
84RPS6KA40.44000032
85CDK80.43211256
86RPS6KA50.43067865
87CDK30.40037076
88MAPK130.39425163
89CDK70.38774539
90FER0.38630911
91PAK30.38505863
92INSRR0.38449897
93CAMK2D0.38008635
94STK38L0.36794880
95FLT30.36721371
96ERBB40.35405528
97EPHB20.34542706
98CDK140.31927407
99PAK40.31662424
100PRKDC0.31509164

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.27078236
2Oxidative phosphorylation_Homo sapiens_hsa001903.26345308
3Parkinsons disease_Homo sapiens_hsa050122.77758642
4Protein export_Homo sapiens_hsa030602.77431931
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.64818596
6Steroid biosynthesis_Homo sapiens_hsa001002.60594218
7Ribosome_Homo sapiens_hsa030102.52494093
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.26682368
9RNA polymerase_Homo sapiens_hsa030202.26052008
10Fatty acid elongation_Homo sapiens_hsa000622.01119528
11Huntingtons disease_Homo sapiens_hsa050162.00509197
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.99571870
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.95551268
14Mismatch repair_Homo sapiens_hsa034301.91887854
15Propanoate metabolism_Homo sapiens_hsa006401.87478585
16Alzheimers disease_Homo sapiens_hsa050101.79418320
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.77905317
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.77052036
19Butanoate metabolism_Homo sapiens_hsa006501.71780496
20DNA replication_Homo sapiens_hsa030301.63678122
21Pyruvate metabolism_Homo sapiens_hsa006201.56454565
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.51923062
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.49579696
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.42737008
25Primary bile acid biosynthesis_Homo sapiens_hsa001201.40912273
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.39727108
27Homologous recombination_Homo sapiens_hsa034401.37403086
28Peroxisome_Homo sapiens_hsa041461.32884393
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.31411679
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.31180479
31Base excision repair_Homo sapiens_hsa034101.30216005
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.30133414
33One carbon pool by folate_Homo sapiens_hsa006701.29118914
34Folate biosynthesis_Homo sapiens_hsa007901.27696611
35Nucleotide excision repair_Homo sapiens_hsa034201.26845156
36Spliceosome_Homo sapiens_hsa030401.26812728
37Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.21305337
38Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.19236865
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.17615210
40Cardiac muscle contraction_Homo sapiens_hsa042601.17463763
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.17321843
42Fatty acid metabolism_Homo sapiens_hsa012121.15695567
43Vitamin B6 metabolism_Homo sapiens_hsa007501.14965960
44Fatty acid degradation_Homo sapiens_hsa000711.14514379
45Pentose and glucuronate interconversions_Homo sapiens_hsa000401.13668895
46Glutathione metabolism_Homo sapiens_hsa004801.13629536
47Non-homologous end-joining_Homo sapiens_hsa034501.12721587
48Basal transcription factors_Homo sapiens_hsa030221.12441377
49RNA degradation_Homo sapiens_hsa030181.11950244
50Retinol metabolism_Homo sapiens_hsa008301.10357514
51Pyrimidine metabolism_Homo sapiens_hsa002401.09533558
52Chemical carcinogenesis_Homo sapiens_hsa052041.07795054
53RNA transport_Homo sapiens_hsa030131.06120567
54Carbon metabolism_Homo sapiens_hsa012001.03364386
55Biosynthesis of amino acids_Homo sapiens_hsa012301.03033339
56Fanconi anemia pathway_Homo sapiens_hsa034601.02765117
57Caffeine metabolism_Homo sapiens_hsa002320.94644651
58Tryptophan metabolism_Homo sapiens_hsa003800.94418279
59Metabolic pathways_Homo sapiens_hsa011000.93555407
60beta-Alanine metabolism_Homo sapiens_hsa004100.93286516
61Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.90009076
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87312274
63Nitrogen metabolism_Homo sapiens_hsa009100.84797290
64Maturity onset diabetes of the young_Homo sapiens_hsa049500.82430064
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.82027823
66Purine metabolism_Homo sapiens_hsa002300.81668249
67Steroid hormone biosynthesis_Homo sapiens_hsa001400.81633946
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81538864
69Selenocompound metabolism_Homo sapiens_hsa004500.79214768
70Sulfur relay system_Homo sapiens_hsa041220.76899047
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74087561
72Sulfur metabolism_Homo sapiens_hsa009200.73973419
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.71702465
74Tyrosine metabolism_Homo sapiens_hsa003500.70797375
75Fat digestion and absorption_Homo sapiens_hsa049750.70510912
76Vitamin digestion and absorption_Homo sapiens_hsa049770.68015349
77Arginine and proline metabolism_Homo sapiens_hsa003300.67540286
78N-Glycan biosynthesis_Homo sapiens_hsa005100.63800873
79Linoleic acid metabolism_Homo sapiens_hsa005910.63243196
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.61882764
81Arginine biosynthesis_Homo sapiens_hsa002200.60341811
82Collecting duct acid secretion_Homo sapiens_hsa049660.58458341
83Phenylalanine metabolism_Homo sapiens_hsa003600.58033070
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45797483
85Phototransduction_Homo sapiens_hsa047440.44968804
86Histidine metabolism_Homo sapiens_hsa003400.43041741
87Cyanoamino acid metabolism_Homo sapiens_hsa004600.41707516
88Cell cycle_Homo sapiens_hsa041100.40905906
89Nicotine addiction_Homo sapiens_hsa050330.40091046
90Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.38346976
91Arachidonic acid metabolism_Homo sapiens_hsa005900.34221670
92Basal cell carcinoma_Homo sapiens_hsa052170.31361798
93Oocyte meiosis_Homo sapiens_hsa041140.31046994
94mRNA surveillance pathway_Homo sapiens_hsa030150.30161096
95Starch and sucrose metabolism_Homo sapiens_hsa005000.29221454
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28580774
97Regulation of autophagy_Homo sapiens_hsa041400.27387250
98Ether lipid metabolism_Homo sapiens_hsa005650.27091858
99Vibrio cholerae infection_Homo sapiens_hsa051100.25492861
100Complement and coagulation cascades_Homo sapiens_hsa046100.24866766

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