C12ORF76

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.68535397
2neuronal action potential propagation (GO:0019227)4.16022055
3gamma-aminobutyric acid transport (GO:0015812)3.89067775
4protein polyglutamylation (GO:0018095)3.56607860
5membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.48091779
6detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.45327665
7G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.35184745
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.28268646
9synaptic transmission, glutamatergic (GO:0035249)3.27550091
10detection of light stimulus involved in sensory perception (GO:0050962)3.26496264
11detection of light stimulus involved in visual perception (GO:0050908)3.26496264
12transmission of nerve impulse (GO:0019226)3.24243445
13regulation of cilium movement (GO:0003352)3.19442249
14protein neddylation (GO:0045116)3.16264897
15axoneme assembly (GO:0035082)3.15999650
16epithelial cilium movement (GO:0003351)3.14979289
17glutamate receptor signaling pathway (GO:0007215)3.13553542
18postsynaptic membrane organization (GO:0001941)3.13303245
19synaptic vesicle maturation (GO:0016188)3.12351138
20membrane depolarization during action potential (GO:0086010)3.11064919
21neuronal action potential (GO:0019228)3.09859802
22neuron cell-cell adhesion (GO:0007158)3.07076123
23protein localization to synapse (GO:0035418)3.04438770
24cilium or flagellum-dependent cell motility (GO:0001539)3.03961233
25pyrimidine nucleobase catabolic process (GO:0006208)3.03878099
26protein localization to cilium (GO:0061512)3.02505230
27ionotropic glutamate receptor signaling pathway (GO:0035235)3.02033525
28response to pheromone (GO:0019236)2.98978084
29negative regulation of heart rate (GO:0010459)2.98964693
30tryptophan catabolic process (GO:0006569)2.97629298
31indole-containing compound catabolic process (GO:0042436)2.97629298
32indolalkylamine catabolic process (GO:0046218)2.97629298
33negative regulation of appetite (GO:0032099)2.95296092
34negative regulation of response to food (GO:0032096)2.95296092
35neuron-neuron synaptic transmission (GO:0007270)2.94998972
36retinal cone cell development (GO:0046549)2.94963172
37central nervous system myelination (GO:0022010)2.94142210
38axon ensheathment in central nervous system (GO:0032291)2.94142210
39indolalkylamine metabolic process (GO:0006586)2.93855592
40behavioral response to ethanol (GO:0048149)2.92754905
41neural tube formation (GO:0001841)2.89167097
42fucose catabolic process (GO:0019317)2.88752700
43L-fucose metabolic process (GO:0042354)2.88752700
44L-fucose catabolic process (GO:0042355)2.88752700
45startle response (GO:0001964)2.88061198
46nonmotile primary cilium assembly (GO:0035058)2.87569080
47regulation of short-term neuronal synaptic plasticity (GO:0048172)2.87098697
48dopamine transport (GO:0015872)2.84660180
49regulation of neurotransmitter uptake (GO:0051580)2.83638104
50cilium movement (GO:0003341)2.82710365
51photoreceptor cell maintenance (GO:0045494)2.75571697
52proline transport (GO:0015824)2.74017500
53serotonin metabolic process (GO:0042428)2.73414284
54negative regulation of synaptic transmission, GABAergic (GO:0032229)2.72821999
55platelet dense granule organization (GO:0060155)2.71905750
56primary amino compound metabolic process (GO:1901160)2.70505442
57amine catabolic process (GO:0009310)2.67574836
58cellular biogenic amine catabolic process (GO:0042402)2.67574836
59C4-dicarboxylate transport (GO:0015740)2.66768991
60regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.66577711
61glycerophospholipid catabolic process (GO:0046475)2.64108141
62reflex (GO:0060004)2.63687199
63negative regulation of neurotransmitter transport (GO:0051589)2.61464054
64cellular ketone body metabolic process (GO:0046950)2.60735080
65kynurenine metabolic process (GO:0070189)2.60128636
66adult walking behavior (GO:0007628)2.60097199
67neurotransmitter-gated ion channel clustering (GO:0072578)2.59979204
68presynaptic membrane organization (GO:0097090)2.59771153
69indole-containing compound metabolic process (GO:0042430)2.59382301
70negative regulation of cytosolic calcium ion concentration (GO:0051481)2.58160613
71presynaptic membrane assembly (GO:0097105)2.57487839
72auditory behavior (GO:0031223)2.56788088
73regulation of microtubule-based movement (GO:0060632)2.56711587
74gamma-aminobutyric acid signaling pathway (GO:0007214)2.55801506
75cilium organization (GO:0044782)2.55349134
76nucleobase catabolic process (GO:0046113)2.55063583
77regulation of voltage-gated calcium channel activity (GO:1901385)2.53932756
78neuromuscular synaptic transmission (GO:0007274)2.52990457
79positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.52846853
80rhodopsin mediated signaling pathway (GO:0016056)2.52285995
81protein K11-linked deubiquitination (GO:0035871)2.52260582
82cilium assembly (GO:0042384)2.51915414
83mitochondrial respiratory chain complex I assembly (GO:0032981)2.50177979
84NADH dehydrogenase complex assembly (GO:0010257)2.50177979
85mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.50177979
86regulation of rhodopsin mediated signaling pathway (GO:0022400)2.49790299
87vocalization behavior (GO:0071625)2.49008268
88behavioral response to cocaine (GO:0048148)2.47478668
89detection of mechanical stimulus involved in sensory perception (GO:0050974)2.46826031
90glycosphingolipid biosynthetic process (GO:0006688)2.46454591
91tryptophan metabolic process (GO:0006568)2.45241855
92sulfation (GO:0051923)2.43805336
93negative regulation of mast cell activation (GO:0033004)2.43006117
94negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.42702080
95negative regulation of translation, ncRNA-mediated (GO:0040033)2.42702080
96regulation of translation, ncRNA-mediated (GO:0045974)2.42702080
97positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.42221231
98tachykinin receptor signaling pathway (GO:0007217)2.41674182
99synaptic transmission, cholinergic (GO:0007271)2.41634915
100neurotransmitter uptake (GO:0001504)2.41463951

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.34335080
2GBX2_23144817_ChIP-Seq_PC3_Human3.57900135
3ZNF274_21170338_ChIP-Seq_K562_Hela2.95330571
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.84260013
5VDR_22108803_ChIP-Seq_LS180_Human2.77519586
6TAF15_26573619_Chip-Seq_HEK293_Human2.50503796
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.46463000
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.46004668
9IGF1R_20145208_ChIP-Seq_DFB_Human2.40305839
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.35374809
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.31253137
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.04015626
13P300_19829295_ChIP-Seq_ESCs_Human1.98348890
14CTBP1_25329375_ChIP-Seq_LNCAP_Human1.92991863
15REST_21632747_ChIP-Seq_MESCs_Mouse1.89573119
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.87777471
17SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.86383337
18EWS_26573619_Chip-Seq_HEK293_Human1.83128776
19FUS_26573619_Chip-Seq_HEK293_Human1.80735928
20AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.77409020
21SMAD4_21799915_ChIP-Seq_A2780_Human1.75424498
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70917484
23ER_23166858_ChIP-Seq_MCF-7_Human1.64332652
24* STAT3_23295773_ChIP-Seq_U87_Human1.62631170
25UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.62281133
26POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.62179451
27TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62179451
28PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61011366
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.59340152
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.57818077
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.57362320
32TCF4_23295773_ChIP-Seq_U87_Human1.54386279
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.54279743
34AR_25329375_ChIP-Seq_VCAP_Human1.53484931
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.52515416
36BCAT_22108803_ChIP-Seq_LS180_Human1.51864325
37SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47058072
38CBP_20019798_ChIP-Seq_JUKART_Human1.46698079
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46698079
40IRF1_19129219_ChIP-ChIP_H3396_Human1.46356812
41RNF2_27304074_Chip-Seq_NSC_Mouse1.45532507
42SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45084890
43AR_21572438_ChIP-Seq_LNCaP_Human1.43698445
44MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42110949
45SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.39605981
46REST_18959480_ChIP-ChIP_MESCs_Mouse1.39410681
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.38286699
48NR3C1_21868756_ChIP-Seq_MCF10A_Human1.37132711
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36879802
50DROSHA_22980978_ChIP-Seq_HELA_Human1.34304977
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34090862
52MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33386121
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.32184004
54PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31173038
55TP53_22573176_ChIP-Seq_HFKS_Human1.29525117
56SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28062492
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.24966958
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.24936594
59PRDM14_20953172_ChIP-Seq_ESCs_Human1.24814295
60TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23798585
61NANOG_19829295_ChIP-Seq_ESCs_Human1.23519661
62SOX2_19829295_ChIP-Seq_ESCs_Human1.23519661
63PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22548419
64RUNX2_22187159_ChIP-Seq_PCA_Human1.22518873
65JARID2_20064375_ChIP-Seq_MESCs_Mouse1.21851644
66TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21117668
67BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20743516
68* TCF4_22108803_ChIP-Seq_LS180_Human1.20210511
69FLI1_21867929_ChIP-Seq_TH2_Mouse1.19626595
70NANOG_18555785_Chip-Seq_ESCs_Mouse1.19097525
71CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.18860712
72SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.18151242
73RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16942252
74EZH2_27294783_Chip-Seq_NPCs_Mouse1.16430232
75SMAD4_21741376_ChIP-Seq_EPCs_Human1.15236393
76KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14612639
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.14066211
78EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13960891
79P53_22387025_ChIP-Seq_ESCs_Mouse1.11041737
80MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09142403
81SOX2_21211035_ChIP-Seq_LN229_Gbm1.09023009
82LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.06888680
83ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04847686
84HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.04747439
85GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03844999
86EZH2_27304074_Chip-Seq_ESCs_Mouse1.03317587
87E2F1_18555785_Chip-Seq_ESCs_Mouse1.02570362
88* FOXA1_25329375_ChIP-Seq_VCAP_Human1.02300204
89* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02300204
90TAL1_26923725_Chip-Seq_HPCs_Mouse1.01724281
91GATA3_21878914_ChIP-Seq_MCF-7_Human1.01395284
92TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01120526
93EZH2_27294783_Chip-Seq_ESCs_Mouse1.00506758
94CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00273976
95CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99844331
96FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98998433
97CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98843791
98CRX_20693478_ChIP-Seq_RETINA_Mouse0.98360122
99TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97100462
100TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.96788661

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.63203076
2MP0001968_abnormal_touch/_nociception3.07224392
3MP0002736_abnormal_nociception_after2.75858093
4MP0009046_muscle_twitch2.64792009
5MP0004859_abnormal_synaptic_plasticity2.63314574
6MP0000569_abnormal_digit_pigmentation2.53857509
7MP0009745_abnormal_behavioral_response2.52564781
8MP0008877_abnormal_DNA_methylation2.49858123
9MP0002272_abnormal_nervous_system2.32166613
10MP0003635_abnormal_synaptic_transmissio2.29660836
11MP0005551_abnormal_eye_electrophysiolog2.29336858
12MP0003787_abnormal_imprinting2.29325940
13MP0001486_abnormal_startle_reflex2.25045926
14MP0006276_abnormal_autonomic_nervous2.23018808
15MP0005423_abnormal_somatic_nervous2.21970211
16MP0002638_abnormal_pupillary_reflex2.17551697
17MP0002064_seizures2.15009932
18MP0005646_abnormal_pituitary_gland2.11668223
19MP0002102_abnormal_ear_morphology2.11336965
20MP0002735_abnormal_chemical_nociception2.01953292
21MP0001501_abnormal_sleep_pattern2.00034213
22MP0002572_abnormal_emotion/affect_behav1.97778229
23MP0001984_abnormal_olfaction1.97272083
24MP0003136_yellow_coat_color1.95615887
25MP0004142_abnormal_muscle_tone1.94684137
26MP0002063_abnormal_learning/memory/cond1.90823669
27MP0002733_abnormal_thermal_nociception1.82192937
28MP0001970_abnormal_pain_threshold1.81228500
29MP0008872_abnormal_physiological_respon1.73400212
30MP0002067_abnormal_sensory_capabilities1.70287966
31MP0002653_abnormal_ependyma_morphology1.68786463
32MP0004270_analgesia1.66881657
33MP0003195_calcinosis1.65711681
34MP0002734_abnormal_mechanical_nocicepti1.63014171
35MP0000372_irregular_coat_pigmentation1.62467908
36MP0001986_abnormal_taste_sensitivity1.61004437
37MP0002557_abnormal_social/conspecific_i1.59324485
38MP0005645_abnormal_hypothalamus_physiol1.59119246
39MP0004885_abnormal_endolymph1.57359887
40MP0001485_abnormal_pinna_reflex1.55699775
41MP0005253_abnormal_eye_physiology1.51856689
42MP0004742_abnormal_vestibular_system1.43746435
43MP0005174_abnormal_tail_pigmentation1.39223235
44MP0000778_abnormal_nervous_system1.39214505
45MP0001529_abnormal_vocalization1.38646850
46MP0004147_increased_porphyrin_level1.35052986
47MP0005386_behavior/neurological_phenoty1.34160183
48MP0004924_abnormal_behavior1.34160183
49MP0000631_abnormal_neuroendocrine_gland1.30645508
50MP0006292_abnormal_olfactory_placode1.29324858
51MP0002822_catalepsy1.26908514
52MP0006072_abnormal_retinal_apoptosis1.23832416
53MP0001905_abnormal_dopamine_level1.23227752
54MP0005167_abnormal_blood-brain_barrier1.23018332
55MP0003122_maternal_imprinting1.21252941
56MP0002837_dystrophic_cardiac_calcinosis1.17265202
57MP0005084_abnormal_gallbladder_morpholo1.17159302
58MP0005410_abnormal_fertilization1.16075255
59MP0010386_abnormal_urinary_bladder1.15587302
60MP0002229_neurodegeneration1.13468128
61MP0004133_heterotaxia1.10169608
62MP0002882_abnormal_neuron_morphology1.07887376
63MP0004043_abnormal_pH_regulation1.05720155
64MP0008569_lethality_at_weaning1.04654308
65MP0005464_abnormal_platelet_physiology1.03725337
66MP0001502_abnormal_circadian_rhythm1.03500510
67MP0003879_abnormal_hair_cell1.02555715
68MP0000955_abnormal_spinal_cord1.02523019
69MP0000230_abnormal_systemic_arterial1.02000302
70MP0002876_abnormal_thyroid_physiology0.99818375
71MP0003633_abnormal_nervous_system0.99554014
72MP0003646_muscle_fatigue0.99510405
73MP0002184_abnormal_innervation0.99058545
74MP0001440_abnormal_grooming_behavior0.98864820
75MP0001963_abnormal_hearing_physiology0.97988763
76MP0003121_genomic_imprinting0.96995116
77MP0002752_abnormal_somatic_nervous0.96377478
78MP0005171_absent_coat_pigmentation0.94774567
79MP0008995_early_reproductive_senescence0.92587024
80MP0003011_delayed_dark_adaptation0.90118874
81MP0003698_abnormal_male_reproductive0.89464449
82MP0002066_abnormal_motor_capabilities/c0.89147856
83MP0004145_abnormal_muscle_electrophysio0.88641442
84MP0008875_abnormal_xenobiotic_pharmacok0.88586297
85MP0002095_abnormal_skin_pigmentation0.88328923
86MP0002909_abnormal_adrenal_gland0.87246960
87MP0002928_abnormal_bile_duct0.87032829
88MP0000015_abnormal_ear_pigmentation0.85685900
89MP0004811_abnormal_neuron_physiology0.84461820
90MP0003631_nervous_system_phenotype0.84394863
91MP0001188_hyperpigmentation0.84286193
92MP0003878_abnormal_ear_physiology0.83507250
93MP0005377_hearing/vestibular/ear_phenot0.83507250
94MP0005195_abnormal_posterior_eye0.81246786
95MP0005394_taste/olfaction_phenotype0.81055512
96MP0005499_abnormal_olfactory_system0.81055512
97MP0004215_abnormal_myocardial_fiber0.80943607
98MP0005075_abnormal_melanosome_morpholog0.80630282
99MP0000427_abnormal_hair_cycle0.78794175
100MP0005187_abnormal_penis_morphology0.77858700

Predicted human phenotypes

RankGene SetZ-score
1Febrile seizures (HP:0002373)4.04801966
2Pancreatic cysts (HP:0001737)4.01366546
3Progressive cerebellar ataxia (HP:0002073)3.78218508
4Pancreatic fibrosis (HP:0100732)3.65288681
5True hermaphroditism (HP:0010459)3.59527224
6Hyperventilation (HP:0002883)3.56933403
7Molar tooth sign on MRI (HP:0002419)3.54887983
8Abnormality of midbrain morphology (HP:0002418)3.54887983
9Focal motor seizures (HP:0011153)3.46074475
10Medial flaring of the eyebrow (HP:0010747)3.30353705
11Nephronophthisis (HP:0000090)3.22089746
12Gaze-evoked nystagmus (HP:0000640)3.21689707
13Focal seizures (HP:0007359)3.15847540
14Congenital stationary night blindness (HP:0007642)3.09763035
15Genetic anticipation (HP:0003743)2.99034963
16Atonic seizures (HP:0010819)2.91543867
17Gait imbalance (HP:0002141)2.88079739
18Decreased central vision (HP:0007663)2.86985404
19Abnormality of the renal medulla (HP:0100957)2.85714106
20Myokymia (HP:0002411)2.83140808
21Abnormality of the renal cortex (HP:0011035)2.76906782
22Congenital primary aphakia (HP:0007707)2.66667133
23Attenuation of retinal blood vessels (HP:0007843)2.65982284
24Broad-based gait (HP:0002136)2.65255568
25Chronic hepatic failure (HP:0100626)2.65098397
26Epileptic encephalopathy (HP:0200134)2.64764512
27Cystic liver disease (HP:0006706)2.58936932
28Dialeptic seizures (HP:0011146)2.58215063
29Abolished electroretinogram (ERG) (HP:0000550)2.57065324
30Type II lissencephaly (HP:0007260)2.56856110
31Abnormal drinking behavior (HP:0030082)2.51420522
32Polydipsia (HP:0001959)2.51420522
33Nephrogenic diabetes insipidus (HP:0009806)2.51115805
34Polyphagia (HP:0002591)2.50038137
35Absent speech (HP:0001344)2.47328418
36Hemiparesis (HP:0001269)2.46835541
37Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.46567331
38Abnormality of alanine metabolism (HP:0010916)2.46567331
39Hyperalaninemia (HP:0003348)2.46567331
40Inability to walk (HP:0002540)2.44932501
41Absent/shortened dynein arms (HP:0200106)2.41542372
42Dynein arm defect of respiratory motile cilia (HP:0012255)2.41542372
43Lissencephaly (HP:0001339)2.39158893
44Prolonged bleeding time (HP:0003010)2.29244846
45Abnormal ciliary motility (HP:0012262)2.28137331
46Protruding tongue (HP:0010808)2.27636511
47Genital tract atresia (HP:0001827)2.23790874
48Abnormal respiratory epithelium morphology (HP:0012253)2.22191308
49Abnormal respiratory motile cilium morphology (HP:0005938)2.22191308
50Vaginal atresia (HP:0000148)2.15410131
51Optic nerve hypoplasia (HP:0000609)2.14541765
52Clumsiness (HP:0002312)2.14381646
53Absence seizures (HP:0002121)2.13209566
54Abnormality of the labia minora (HP:0012880)2.09849738
55Congenital hepatic fibrosis (HP:0002612)2.07512367
56Thyroid-stimulating hormone excess (HP:0002925)2.05806471
57Aplasia/Hypoplasia of the tibia (HP:0005772)2.05764229
58Cerebellar dysplasia (HP:0007033)2.03651614
59Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.01404958
60Sclerocornea (HP:0000647)1.99476134
61Renal cortical cysts (HP:0000803)1.98567830
62Decreased circulating renin level (HP:0003351)1.97976950
63Poor coordination (HP:0002370)1.97731384
64Acute necrotizing encephalopathy (HP:0006965)1.97324049
65Congenital sensorineural hearing impairment (HP:0008527)1.96769699
66Bony spicule pigmentary retinopathy (HP:0007737)1.96715425
67Progressive inability to walk (HP:0002505)1.95745151
68Abnormal rod and cone electroretinograms (HP:0008323)1.93675120
69Drooling (HP:0002307)1.92563859
70Limb dystonia (HP:0002451)1.92097188
71Fair hair (HP:0002286)1.90671850
72Anencephaly (HP:0002323)1.90416498
733-Methylglutaconic aciduria (HP:0003535)1.90031538
74Male pseudohermaphroditism (HP:0000037)1.89212689
75Polyuria (HP:0000103)1.88484058
76Stomach cancer (HP:0012126)1.88397311
77Urinary bladder sphincter dysfunction (HP:0002839)1.88326354
78Oligodactyly (hands) (HP:0001180)1.87814560
79Diplopia (HP:0000651)1.87155681
80Abnormality of binocular vision (HP:0011514)1.87155681
81Tubular atrophy (HP:0000092)1.85858783
82Progressive macrocephaly (HP:0004481)1.84375348
83Degeneration of the lateral corticospinal tracts (HP:0002314)1.83213525
84Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.83213525
85Abnormal respiratory motile cilium physiology (HP:0012261)1.81284602
86Aplasia/Hypoplasia of the tongue (HP:0010295)1.81013234
87Specific learning disability (HP:0001328)1.80255605
88Hypothermia (HP:0002045)1.79632436
89Widely spaced teeth (HP:0000687)1.78027444
90Postaxial hand polydactyly (HP:0001162)1.76065480
91Pachygyria (HP:0001302)1.75570854
92Abnormality of macular pigmentation (HP:0008002)1.74946476
93Epileptiform EEG discharges (HP:0011182)1.73792768
94Bile duct proliferation (HP:0001408)1.73406208
95Abnormal biliary tract physiology (HP:0012439)1.73406208
96Excessive salivation (HP:0003781)1.73185645
97Postaxial foot polydactyly (HP:0001830)1.73127007
98Mitochondrial inheritance (HP:0001427)1.73115361
99Keratoconus (HP:0000563)1.72115698
100Increased corneal curvature (HP:0100692)1.72115698

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.16669299
2TAOK32.83149860
3ADRBK22.48137243
4CASK2.46957040
5MAP4K22.41356161
6MAPK132.30536584
7BMPR1B2.27255477
8MARK12.20690867
9PINK12.16852067
10MAP3K42.16826229
11WNK32.16157737
12DAPK22.12976474
13NTRK32.01066673
14EPHA41.99267839
15ZAK1.94784408
16ACVR1B1.74357798
17TNIK1.72118540
18INSRR1.69388055
19GRK11.50277187
20WNK41.49749828
21NTRK21.49251820
22PLK21.43782184
23NUAK11.39279807
24MAP2K71.38761878
25OXSR11.30768896
26PAK31.30367931
27STK391.21205075
28PRKCG1.20345074
29TXK1.19573570
30DYRK21.15633645
31CSNK1G21.08166391
32ADRBK11.06043203
33TEC1.05043754
34TRIM281.03592116
35GRK51.03348286
36PTK2B1.01747637
37PNCK0.97258499
38TNK20.97232110
39TLK10.96878972
40MINK10.96721391
41CAMKK20.95252126
42PRKCE0.93543777
43CSNK1G10.93535775
44SIK20.92349819
45CSNK1G30.89454337
46MKNK20.88965398
47BCR0.88201796
48DYRK1A0.87247743
49SGK20.86974261
50PKN10.86609666
51MAP2K40.85174015
52CSNK1A1L0.84346495
53CAMK2A0.78339340
54SGK4940.73379961
55SGK2230.73379961
56CAMK10.72432911
57SYK0.71809391
58MST40.67764856
59UHMK10.65134430
60CDK190.64721400
61PAK60.63061409
62IRAK10.61441493
63CDK50.59951166
64ERBB20.59009481
65ERBB30.58801099
66NLK0.57293746
67PHKG10.56165263
68PHKG20.56165263
69PRKCQ0.56157083
70AKT30.55999766
71PRKACA0.53141819
72PRKG10.47583742
73STK110.47207918
74DYRK30.47139427
75CSNK1D0.45423540
76MARK30.45201637
77BMPR20.45199515
78PIK3CG0.43913422
79EPHA30.43842526
80CSNK1A10.43554911
81CAMKK10.43484721
82CAMK1G0.42722901
83PIK3CA0.42426297
84MAP2K60.42262588
85PRKCA0.41425400
86PRKCZ0.41337428
87BTK0.40496507
88FGFR20.40388071
89SGK10.39837711
90RIPK40.39823410
91PRKCH0.39510650
92FER0.39065767
93CAMK40.37034000
94ITK0.36447501
95STK38L0.36231804
96RPS6KA50.33875792
97PRKCB0.31451185
98CDK30.31110562
99TIE10.30685515
100BCKDK0.30498903

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.69823784
2Phototransduction_Homo sapiens_hsa047442.94754866
3Morphine addiction_Homo sapiens_hsa050322.55703427
4Nitrogen metabolism_Homo sapiens_hsa009102.55399613
5GABAergic synapse_Homo sapiens_hsa047272.36689479
6Circadian entrainment_Homo sapiens_hsa047132.29435703
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.25272940
8Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.21059597
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.13493515
10Glutamatergic synapse_Homo sapiens_hsa047242.13133505
11Taste transduction_Homo sapiens_hsa047422.09101599
12Olfactory transduction_Homo sapiens_hsa047401.96960296
13Butanoate metabolism_Homo sapiens_hsa006501.95043429
14Linoleic acid metabolism_Homo sapiens_hsa005911.94576317
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.93748426
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.92162950
17Serotonergic synapse_Homo sapiens_hsa047261.78634866
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.76318970
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.71397798
20Synaptic vesicle cycle_Homo sapiens_hsa047211.67856901
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.63964952
22Oxidative phosphorylation_Homo sapiens_hsa001901.61236368
23Insulin secretion_Homo sapiens_hsa049111.58365000
24Collecting duct acid secretion_Homo sapiens_hsa049661.55365244
25Dopaminergic synapse_Homo sapiens_hsa047281.50529330
26Ether lipid metabolism_Homo sapiens_hsa005651.47143475
27Amphetamine addiction_Homo sapiens_hsa050311.42109615
28Salivary secretion_Homo sapiens_hsa049701.38675054
29Regulation of autophagy_Homo sapiens_hsa041401.37960765
30Parkinsons disease_Homo sapiens_hsa050121.36826264
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.36011532
32Cocaine addiction_Homo sapiens_hsa050301.34231247
33Long-term depression_Homo sapiens_hsa047301.33397216
34Calcium signaling pathway_Homo sapiens_hsa040201.32564181
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.27062825
36ABC transporters_Homo sapiens_hsa020101.21281250
37Cholinergic synapse_Homo sapiens_hsa047251.19200044
38SNARE interactions in vesicular transport_Homo sapiens_hsa041301.08426250
39Gastric acid secretion_Homo sapiens_hsa049711.08310995
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.07473503
41Tryptophan metabolism_Homo sapiens_hsa003801.07167790
42Cardiac muscle contraction_Homo sapiens_hsa042601.04832805
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.98482031
44Arachidonic acid metabolism_Homo sapiens_hsa005900.96265814
45Platelet activation_Homo sapiens_hsa046110.93618583
46Vascular smooth muscle contraction_Homo sapiens_hsa042700.92242608
47Oxytocin signaling pathway_Homo sapiens_hsa049210.91068337
48Primary bile acid biosynthesis_Homo sapiens_hsa001200.90294701
49Huntingtons disease_Homo sapiens_hsa050160.89721453
50Renin secretion_Homo sapiens_hsa049240.89515128
51Alzheimers disease_Homo sapiens_hsa050100.88769946
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.88191215
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.88098113
54Basal transcription factors_Homo sapiens_hsa030220.87264651
55cAMP signaling pathway_Homo sapiens_hsa040240.86910991
56Propanoate metabolism_Homo sapiens_hsa006400.86512714
57Circadian rhythm_Homo sapiens_hsa047100.80979988
58Steroid hormone biosynthesis_Homo sapiens_hsa001400.80895847
59Protein export_Homo sapiens_hsa030600.79506859
60beta-Alanine metabolism_Homo sapiens_hsa004100.78200831
61Ovarian steroidogenesis_Homo sapiens_hsa049130.77329007
62Aldosterone synthesis and secretion_Homo sapiens_hsa049250.76897943
63Glycerolipid metabolism_Homo sapiens_hsa005610.76669944
64Dorso-ventral axis formation_Homo sapiens_hsa043200.74732213
65Chemical carcinogenesis_Homo sapiens_hsa052040.72646015
66RNA polymerase_Homo sapiens_hsa030200.71845463
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69502377
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67888311
69Peroxisome_Homo sapiens_hsa041460.66258226
70Homologous recombination_Homo sapiens_hsa034400.64746403
71Pancreatic secretion_Homo sapiens_hsa049720.64147186
72Fanconi anemia pathway_Homo sapiens_hsa034600.63153250
73Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59534909
74Caffeine metabolism_Homo sapiens_hsa002320.59151813
75Alcoholism_Homo sapiens_hsa050340.58178878
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56426748
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.55364241
78Selenocompound metabolism_Homo sapiens_hsa004500.54585720
79Intestinal immune network for IgA production_Homo sapiens_hsa046720.52716239
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51554435
81Long-term potentiation_Homo sapiens_hsa047200.50183593
82Histidine metabolism_Homo sapiens_hsa003400.49341186
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46713478
84Ras signaling pathway_Homo sapiens_hsa040140.46514965
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45285296
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44702191
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43354636
88Retinol metabolism_Homo sapiens_hsa008300.43161982
89Gap junction_Homo sapiens_hsa045400.42521296
90Asthma_Homo sapiens_hsa053100.41979399
91Steroid biosynthesis_Homo sapiens_hsa001000.40788349
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.40162601
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.39694299
94RNA degradation_Homo sapiens_hsa030180.39571096
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38735015
96Purine metabolism_Homo sapiens_hsa002300.36790606
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34805090
98Axon guidance_Homo sapiens_hsa043600.32882979
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32099089
100Metabolic pathways_Homo sapiens_hsa011000.30351345

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