C12ORF73

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.87596078
2ATP synthesis coupled proton transport (GO:0015986)5.41311639
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.41311639
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.97476074
5mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.85350836
6mitochondrial respiratory chain complex I assembly (GO:0032981)4.85350836
7NADH dehydrogenase complex assembly (GO:0010257)4.85350836
8protein complex biogenesis (GO:0070271)4.78571129
9establishment of protein localization to mitochondrial membrane (GO:0090151)4.74148525
10chaperone-mediated protein transport (GO:0072321)4.68590208
11mitochondrial respiratory chain complex assembly (GO:0033108)4.67626238
12respiratory electron transport chain (GO:0022904)4.45670581
13electron transport chain (GO:0022900)4.37748025
14viral transcription (GO:0019083)3.96805160
15regulation of mitochondrial translation (GO:0070129)3.96091506
16translational termination (GO:0006415)3.92511013
17SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.76706365
18cotranslational protein targeting to membrane (GO:0006613)3.75562174
19ribosomal small subunit biogenesis (GO:0042274)3.74585181
20ribosomal small subunit assembly (GO:0000028)3.70321040
21respiratory chain complex IV assembly (GO:0008535)3.69670333
22protein targeting to ER (GO:0045047)3.65300968
23protein neddylation (GO:0045116)3.61018577
24peptidyl-histidine modification (GO:0018202)3.60349122
25establishment of protein localization to endoplasmic reticulum (GO:0072599)3.52590899
26maturation of SSU-rRNA (GO:0030490)3.52486208
27protein targeting to mitochondrion (GO:0006626)3.45857790
28protein localization to endoplasmic reticulum (GO:0070972)3.44500912
29pseudouridine synthesis (GO:0001522)3.39788621
30translational elongation (GO:0006414)3.35579294
31cytochrome complex assembly (GO:0017004)3.34920850
32protein-cofactor linkage (GO:0018065)3.34232912
33transcription elongation from RNA polymerase III promoter (GO:0006385)3.32179581
34termination of RNA polymerase III transcription (GO:0006386)3.32179581
35establishment of protein localization to mitochondrion (GO:0072655)3.30887452
36proteasome assembly (GO:0043248)3.25799914
37protein localization to mitochondrion (GO:0070585)3.24649286
38inner mitochondrial membrane organization (GO:0007007)3.23379264
39DNA damage response, detection of DNA damage (GO:0042769)3.22996936
40translation (GO:0006412)3.22478008
41nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.21924305
42cullin deneddylation (GO:0010388)3.19792583
43ATP biosynthetic process (GO:0006754)3.19437813
44exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.15780204
45hydrogen ion transmembrane transport (GO:1902600)3.15601211
46intracellular protein transmembrane import (GO:0044743)3.11545082
47ribosomal large subunit biogenesis (GO:0042273)3.11324998
48translational initiation (GO:0006413)3.11045950
49purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.10372450
50purine nucleoside triphosphate biosynthetic process (GO:0009145)3.10126904
51cellular component biogenesis (GO:0044085)3.07027813
52behavioral response to nicotine (GO:0035095)3.03569224
53oxidative phosphorylation (GO:0006119)3.02423996
54cellular protein complex disassembly (GO:0043624)3.02114252
55nonmotile primary cilium assembly (GO:0035058)3.00548393
56viral life cycle (GO:0019058)2.99010695
57spliceosomal snRNP assembly (GO:0000387)2.98858203
58chromatin remodeling at centromere (GO:0031055)2.98702028
59tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.98247385
60RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.98247385
61nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.97342051
62platelet dense granule organization (GO:0060155)2.92250367
63CENP-A containing nucleosome assembly (GO:0034080)2.89574476
64rRNA modification (GO:0000154)2.87245799
65ribonucleoside triphosphate biosynthetic process (GO:0009201)2.84127001
66protein deneddylation (GO:0000338)2.83433867
67GTP biosynthetic process (GO:0006183)2.81665465
68proton transport (GO:0015992)2.80164093
69water-soluble vitamin biosynthetic process (GO:0042364)2.78618990
707-methylguanosine mRNA capping (GO:0006370)2.76992646
71pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.76833028
72mitochondrial transport (GO:0006839)2.74207568
73hydrogen transport (GO:0006818)2.74188432
74tRNA processing (GO:0008033)2.71814880
75protein K6-linked ubiquitination (GO:0085020)2.71411593
767-methylguanosine RNA capping (GO:0009452)2.69449467
77RNA capping (GO:0036260)2.69449467
78rRNA processing (GO:0006364)2.68243886
79kinetochore assembly (GO:0051382)2.64465009
80preassembly of GPI anchor in ER membrane (GO:0016254)2.61753984
81ribonucleoprotein complex biogenesis (GO:0022613)2.61744357
82protein complex disassembly (GO:0043241)2.61089254
83DNA replication checkpoint (GO:0000076)2.60855825
84nucleoside triphosphate biosynthetic process (GO:0009142)2.59881375
85organelle disassembly (GO:1903008)2.58457148
86tRNA metabolic process (GO:0006399)2.58336547
87macromolecular complex disassembly (GO:0032984)2.57529888
88rRNA metabolic process (GO:0016072)2.57368016
89intracellular protein transmembrane transport (GO:0065002)2.56625317
90replication fork processing (GO:0031297)2.56220483
91protein transmembrane transport (GO:0071806)2.55014380
92base-excision repair, AP site formation (GO:0006285)2.54956364
93nuclear-transcribed mRNA catabolic process (GO:0000956)2.49923569
94aerobic respiration (GO:0009060)2.49616747
95negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.45658576
96histone exchange (GO:0043486)2.44402675
97UTP biosynthetic process (GO:0006228)2.44080768
98mannosylation (GO:0097502)2.43796552
99resolution of meiotic recombination intermediates (GO:0000712)2.43602972
100deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.42803167

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.89313749
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.32922728
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.99582818
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.85290211
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.46675882
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.42478738
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.35017906
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.15110033
9MYC_18555785_ChIP-Seq_MESCs_Mouse3.02561872
10CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.69542659
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.61716142
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.58499020
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.50335309
14ELK1_19687146_ChIP-ChIP_HELA_Human2.48292761
15VDR_23849224_ChIP-Seq_CD4+_Human2.44979367
16THAP11_20581084_ChIP-Seq_MESCs_Mouse2.35064464
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.25923180
18PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.23571222
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.20288299
20XRN2_22483619_ChIP-Seq_HELA_Human2.14192814
21ZNF274_21170338_ChIP-Seq_K562_Hela2.12926141
22DCP1A_22483619_ChIP-Seq_HELA_Human2.11588692
23* FOXP3_21729870_ChIP-Seq_TREG_Human2.10841955
24MYC_18358816_ChIP-ChIP_MESCs_Mouse2.10222127
25TTF2_22483619_ChIP-Seq_HELA_Human2.05472192
26* GABP_19822575_ChIP-Seq_HepG2_Human1.98598218
27PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96335490
28MYC_19030024_ChIP-ChIP_MESCs_Mouse1.94087697
29SRF_21415370_ChIP-Seq_HL-1_Mouse1.92050164
30MYC_18940864_ChIP-ChIP_HL60_Human1.86468740
31FUS_26573619_Chip-Seq_HEK293_Human1.84785881
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.79191402
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.76317136
34YY1_21170310_ChIP-Seq_MESCs_Mouse1.75607829
35E2F1_18555785_ChIP-Seq_MESCs_Mouse1.71171026
36ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.70484983
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.69614354
38EWS_26573619_Chip-Seq_HEK293_Human1.67645739
39E2F7_22180533_ChIP-Seq_HELA_Human1.67291676
40MYC_19079543_ChIP-ChIP_MESCs_Mouse1.67001981
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62663388
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.55298624
43FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.54925112
44IGF1R_20145208_ChIP-Seq_DFB_Human1.53736920
45PADI4_21655091_ChIP-ChIP_MCF-7_Human1.52388089
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.44531242
47NELFA_20434984_ChIP-Seq_ESCs_Mouse1.43564773
48POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.35522061
49TP63_19390658_ChIP-ChIP_HaCaT_Human1.29966062
50RBPJ_22232070_ChIP-Seq_NCS_Mouse1.28053405
51EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.27466492
52KDM5A_27292631_Chip-Seq_BREAST_Human1.24564029
53MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.23795713
54VDR_22108803_ChIP-Seq_LS180_Human1.23147841
55SOX2_16153702_ChIP-ChIP_HESCs_Human1.22054506
56IRF1_19129219_ChIP-ChIP_H3396_Human1.20761195
57POU5F1_16153702_ChIP-ChIP_HESCs_Human1.20176272
58ZFP57_27257070_Chip-Seq_ESCs_Mouse1.16981586
59MYCN_18555785_ChIP-Seq_MESCs_Mouse1.15528477
60CBX2_27304074_Chip-Seq_ESCs_Mouse1.14000156
61EZH2_22144423_ChIP-Seq_EOC_Human1.13895978
62E2F1_21310950_ChIP-Seq_MCF-7_Human1.13720153
63SALL1_21062744_ChIP-ChIP_HESCs_Human1.13217272
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13121353
65TP53_22573176_ChIP-Seq_HFKS_Human1.12233489
66CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11687876
67BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10891259
68HOXB4_20404135_ChIP-ChIP_EML_Mouse1.10376727
69POU3F2_20337985_ChIP-ChIP_501MEL_Human1.08779877
70NOTCH1_21737748_ChIP-Seq_TLL_Human1.08018830
71CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.07021257
72ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06559166
73ELK1_22589737_ChIP-Seq_MCF10A_Human1.05541657
74RNF2_27304074_Chip-Seq_NSC_Mouse1.04630557
75SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.03365930
76CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.02886430
77BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02814669
78E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01001215
79GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97920431
80TAF15_26573619_Chip-Seq_HEK293_Human0.97254107
81FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97000611
82EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96390459
83P300_19829295_ChIP-Seq_ESCs_Human0.96095114
84ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.95476561
85DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95386148
86NANOG_16153702_ChIP-ChIP_HESCs_Human0.92254561
87CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.92105430
88CTBP1_25329375_ChIP-Seq_LNCAP_Human0.91274017
89GBX2_23144817_ChIP-Seq_PC3_Human0.90548435
90SOX2_18555785_ChIP-Seq_MESCs_Mouse0.88079567
91HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.86860314
92CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.85172923
93MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.83812096
94KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.81998434
95ZFX_18555785_ChIP-Seq_MESCs_Mouse0.81944539
96KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.81931066
97SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.80596065
98GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.80359200
99* FOXP1_21924763_ChIP-Seq_HESCs_Human0.77295196
100NCOR_22424771_ChIP-Seq_293T_Human0.76444717

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001529_abnormal_vocalization2.80486702
2MP0006292_abnormal_olfactory_placode2.75259805
3MP0003880_abnormal_central_pattern2.51743944
4MP0002102_abnormal_ear_morphology2.21846012
5MP0008789_abnormal_olfactory_epithelium2.14715669
6MP0009379_abnormal_foot_pigmentation2.13564586
7MP0002938_white_spotting2.13007148
8MP0008058_abnormal_DNA_repair2.06371113
9MP0003693_abnormal_embryo_hatching1.94024722
10MP0005394_taste/olfaction_phenotype1.91434722
11MP0005499_abnormal_olfactory_system1.91434722
12MP0002653_abnormal_ependyma_morphology1.86363841
13MP0002234_abnormal_pharynx_morphology1.84426341
14MP0003890_abnormal_embryonic-extraembry1.73662209
15MP0005423_abnormal_somatic_nervous1.71231788
16MP0004145_abnormal_muscle_electrophysio1.69410558
17MP0003122_maternal_imprinting1.69156395
18MP0004147_increased_porphyrin_level1.68273128
19MP0006276_abnormal_autonomic_nervous1.64739771
20MP0006072_abnormal_retinal_apoptosis1.63640158
21MP0002822_catalepsy1.62564166
22MP0004142_abnormal_muscle_tone1.60418303
23MP0003136_yellow_coat_color1.60200971
24MP0008877_abnormal_DNA_methylation1.59907488
25MP0004133_heterotaxia1.59901345
26MP0002736_abnormal_nociception_after1.54702898
27MP0006036_abnormal_mitochondrial_physio1.54394398
28MP0000372_irregular_coat_pigmentation1.54331191
29MP0003718_maternal_effect1.53660031
30MP0010094_abnormal_chromosome_stability1.53383257
31MP0000049_abnormal_middle_ear1.53063420
32MP0003121_genomic_imprinting1.49421299
33MP0002638_abnormal_pupillary_reflex1.49418525
34MP0009046_muscle_twitch1.48507058
35MP0000631_abnormal_neuroendocrine_gland1.47631424
36MP0002160_abnormal_reproductive_system1.46682526
37MP0005551_abnormal_eye_electrophysiolog1.44311620
38MP0006035_abnormal_mitochondrial_morpho1.42539000
39MP0002837_dystrophic_cardiac_calcinosis1.40059348
40MP0005253_abnormal_eye_physiology1.38992485
41MP0001984_abnormal_olfaction1.36770390
42MP0003186_abnormal_redox_activity1.35381943
43MP0010030_abnormal_orbit_morphology1.33849849
44MP0001968_abnormal_touch/_nociception1.32357895
45MP0001188_hyperpigmentation1.29934330
46MP0001293_anophthalmia1.29807839
47MP0003567_abnormal_fetal_cardiomyocyte1.28638454
48MP0004957_abnormal_blastocyst_morpholog1.24928712
49MP0003786_premature_aging1.24831546
50MP0008995_early_reproductive_senescence1.22013431
51MP0002163_abnormal_gland_morphology1.21552513
52MP0001764_abnormal_homeostasis1.20801852
53MP0005084_abnormal_gallbladder_morpholo1.18547509
54MP0003011_delayed_dark_adaptation1.18131006
55MP0008932_abnormal_embryonic_tissue1.16472117
56MP0004742_abnormal_vestibular_system1.16295361
57MP0002210_abnormal_sex_determination1.15114762
58MP0002751_abnormal_autonomic_nervous1.14606765
59MP0009745_abnormal_behavioral_response1.13801603
60MP0000778_abnormal_nervous_system1.13647696
61MP0003937_abnormal_limbs/digits/tail_de1.09011943
62MP0002272_abnormal_nervous_system1.08936418
63MP0005646_abnormal_pituitary_gland1.07975722
64MP0003077_abnormal_cell_cycle1.06955249
65MP0001485_abnormal_pinna_reflex1.06671899
66MP0002184_abnormal_innervation1.06557008
67MP0004885_abnormal_endolymph1.05989714
68MP0003806_abnormal_nucleotide_metabolis1.05714979
69MP0003111_abnormal_nucleus_morphology1.05531962
70MP0002752_abnormal_somatic_nervous1.01129050
71MP0001486_abnormal_startle_reflex0.97681159
72MP0003123_paternal_imprinting0.96244123
73MP0003119_abnormal_digestive_system0.95212148
74MP0005645_abnormal_hypothalamus_physiol0.94466995
75MP0002095_abnormal_skin_pigmentation0.93982439
76MP0003787_abnormal_imprinting0.92970475
77MP0002557_abnormal_social/conspecific_i0.92524828
78MP0002233_abnormal_nose_morphology0.91953742
79MP0001905_abnormal_dopamine_level0.91470021
80MP0003938_abnormal_ear_development0.90029409
81MP0003755_abnormal_palate_morphology0.90018931
82MP0005195_abnormal_posterior_eye0.89819636
83MP0001324_abnormal_eye_pigmentation0.89194206
84MP0001145_abnormal_male_reproductive0.88885562
85MP0005391_vision/eye_phenotype0.88885208
86MP0005389_reproductive_system_phenotype0.88019443
87MP0000026_abnormal_inner_ear0.87580641
88MP0008875_abnormal_xenobiotic_pharmacok0.87231271
89MP0002572_abnormal_emotion/affect_behav0.87195771
90MP0002067_abnormal_sensory_capabilities0.86906154
91MP0000955_abnormal_spinal_cord0.86868498
92MP0001286_abnormal_eye_development0.86605740
93MP0000653_abnormal_sex_gland0.86475477
94MP0003137_abnormal_impulse_conducting0.86445397
95MP0005379_endocrine/exocrine_gland_phen0.86388089
96MP0003635_abnormal_synaptic_transmissio0.84946454
97MP0002277_abnormal_respiratory_mucosa0.84253515
98MP0009697_abnormal_copulation0.83215093
99MP0001929_abnormal_gametogenesis0.82602753
100MP0008872_abnormal_physiological_respon0.82481581

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.12967958
2Mitochondrial inheritance (HP:0001427)4.69260741
3Abnormal mitochondria in muscle tissue (HP:0008316)4.66763844
4Increased hepatocellular lipid droplets (HP:0006565)4.65643443
5Acute encephalopathy (HP:0006846)4.46273884
6Increased CSF lactate (HP:0002490)4.24523540
7Progressive macrocephaly (HP:0004481)4.21874380
8Lipid accumulation in hepatocytes (HP:0006561)4.14879411
9Renal Fanconi syndrome (HP:0001994)4.08973247
10Hepatocellular necrosis (HP:0001404)3.96278338
11Hepatic necrosis (HP:0002605)3.65004743
12Cerebral edema (HP:0002181)3.36081058
13Abnormal number of erythroid precursors (HP:0012131)3.31052500
14Increased intramyocellular lipid droplets (HP:0012240)3.29296734
15Abnormality of cells of the erythroid lineage (HP:0012130)3.14999315
16Decreased activity of mitochondrial respiratory chain (HP:0008972)3.14012421
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.14012421
183-Methylglutaconic aciduria (HP:0003535)3.13822015
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.07071930
20Increased serum lactate (HP:0002151)2.87202317
21Lactic acidosis (HP:0003128)2.86458967
22Molar tooth sign on MRI (HP:0002419)2.84861553
23Abnormality of midbrain morphology (HP:0002418)2.84861553
24Optic disc pallor (HP:0000543)2.68710499
25Exercise intolerance (HP:0003546)2.60946993
26Increased muscle lipid content (HP:0009058)2.59839410
27Reticulocytopenia (HP:0001896)2.56201068
28Exertional dyspnea (HP:0002875)2.54781674
29Abnormality of renal resorption (HP:0011038)2.51937270
30Pancreatic cysts (HP:0001737)2.47383395
31Respiratory failure (HP:0002878)2.45066181
32Pancreatic fibrosis (HP:0100732)2.43553729
33True hermaphroditism (HP:0010459)2.43349420
34Respiratory difficulties (HP:0002880)2.40828714
35Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.39298668
36Hyperglycinemia (HP:0002154)2.36392304
37Medial flaring of the eyebrow (HP:0010747)2.35462223
38Macrocytic anemia (HP:0001972)2.34931975
39Leukodystrophy (HP:0002415)2.34454813
40Glycosuria (HP:0003076)2.33970746
41Abnormality of urine glucose concentration (HP:0011016)2.33970746
42Methylmalonic acidemia (HP:0002912)2.27256806
43Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.23423125
44Abnormality of alanine metabolism (HP:0010916)2.23423125
45Hyperalaninemia (HP:0003348)2.23423125
46Colon cancer (HP:0003003)2.21639193
47Gait imbalance (HP:0002141)2.14239721
48Abnormality of the labia minora (HP:0012880)2.13351550
49Methylmalonic aciduria (HP:0012120)2.05727170
50Congenital primary aphakia (HP:0007707)2.04236592
51Hyperphosphaturia (HP:0003109)2.03541462
52Type I transferrin isoform profile (HP:0003642)2.03192019
53Nephronophthisis (HP:0000090)2.02308987
54Poor suck (HP:0002033)2.00932777
55Abnormality of the anterior horn cell (HP:0006802)1.99497471
56Degeneration of anterior horn cells (HP:0002398)1.99497471
57Lethargy (HP:0001254)1.98219243
58Increased serum pyruvate (HP:0003542)1.96769567
59Nephrogenic diabetes insipidus (HP:0009806)1.93452170
60CNS demyelination (HP:0007305)1.83374142
61Abnormality of glycolysis (HP:0004366)1.82071345
62Abnormality of serum amino acid levels (HP:0003112)1.81529347
63Pendular nystagmus (HP:0012043)1.81198405
64Intestinal atresia (HP:0011100)1.81148672
65Sclerocornea (HP:0000647)1.80968566
66X-linked dominant inheritance (HP:0001423)1.77360527
67Aplasia/Hypoplasia of the sacrum (HP:0008517)1.76989662
68Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.75716857
69Myokymia (HP:0002411)1.75615443
70Hyperglycinuria (HP:0003108)1.75585212
71Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.74619582
72Abnormal protein N-linked glycosylation (HP:0012347)1.74619582
73Abnormal protein glycosylation (HP:0012346)1.74619582
74Abnormal glycosylation (HP:0012345)1.74619582
75Absent thumb (HP:0009777)1.73902046
76Anencephaly (HP:0002323)1.72006534
77Generalized aminoaciduria (HP:0002909)1.70739952
78Occipital encephalocele (HP:0002085)1.69549055
79Rib fusion (HP:0000902)1.69214587
80Abnormality of the pons (HP:0007361)1.68838419
81Genital tract atresia (HP:0001827)1.68146296
82Aplasia/Hypoplasia of the uvula (HP:0010293)1.67618705
83Limb dystonia (HP:0002451)1.67296553
84Vaginal atresia (HP:0000148)1.66751727
85Renal tubular dysfunction (HP:0000124)1.63264857
86Congenital stationary night blindness (HP:0007642)1.63119632
87Abnormality of glycine metabolism (HP:0010895)1.61255547
88Abnormality of serine family amino acid metabolism (HP:0010894)1.61255547
89Triphalangeal thumb (HP:0001199)1.60647422
90Meckel diverticulum (HP:0002245)1.59286958
91Hypoplasia of the pons (HP:0012110)1.59216362
92Emotional lability (HP:0000712)1.58895858
93Pallor (HP:0000980)1.58682256
94Abnormality of the ileum (HP:0001549)1.57570609
95Abnormality of the renal medulla (HP:0100957)1.57503465
96Retinal dysplasia (HP:0007973)1.56926742
97Microvesicular hepatic steatosis (HP:0001414)1.52671991
98Stenosis of the external auditory canal (HP:0000402)1.51550015
99Abnormal urine phosphate concentration (HP:0012599)1.50908921
100Type II lissencephaly (HP:0007260)1.49692495

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K23.11831040
2STK162.98949601
3WNK32.78956251
4VRK22.69372113
5CASK2.37949379
6SRPK12.37070677
7BCKDK2.24386574
8ZAK2.08775681
9BUB12.06971714
10TRIM281.99964074
11CDC71.98386023
12MAP2K71.97172115
13DYRK21.96550847
14MAP3K41.96135231
15VRK11.84368138
16BMPR1B1.82238179
17NME11.81048449
18TNIK1.80750111
19TLK11.78414136
20PLK41.70457614
21NME21.67204600
22MARK11.66345121
23NEK11.65324666
24DYRK31.54949716
25PBK1.52728311
26CSNK1G31.50832519
27CSNK1G21.49860124
28WEE11.49793754
29PINK11.43853539
30MAPK131.39624796
31BCR1.38551418
32CDK191.37259063
33PDK21.31963601
34CSNK1A1L1.31900522
35CSNK1G11.31900037
36EIF2AK31.22844779
37PLK31.19141423
38MKNK11.18693312
39NUAK11.17809894
40WNK41.14356530
41MKNK21.13397588
42BRSK21.13083875
43PHKG11.11317917
44PHKG21.11317917
45PNCK1.11002173
46PLK11.06877728
47TAF11.05465678
48MST40.99018953
49PLK20.95332630
50MAP2K40.94206366
51EIF2AK10.93133742
52GRK10.92996838
53PAK30.91458091
54OBSCN0.90561648
55ADRBK20.90286100
56FRK0.90257908
57CHEK20.89337593
58INSRR0.88773550
59MINK10.86424452
60BRSK10.86220198
61PRKCG0.84557173
62MAP3K120.84224779
63ACVR1B0.83957250
64PIM20.83927221
65TSSK60.81918015
66ATR0.80438916
67PASK0.80359939
68AURKA0.79946469
69OXSR10.79778632
70ERBB30.78416238
71STK38L0.73199212
72TTK0.72054468
73RPS6KA50.66675321
74CSNK2A20.63323476
75CSNK2A10.61814199
76AURKB0.60849279
77MUSK0.59864460
78CSNK1A10.55654659
79ATM0.54405877
80EPHA40.53857758
81PRKCI0.53177722
82LIMK10.53150440
83NEK20.52725438
84PRKCE0.52654091
85CCNB10.52312463
86CDK80.50781751
87MAPKAPK50.48507784
88CSNK1E0.48081241
89RPS6KA40.47819364
90NTRK20.47274801
91MAPK150.46258756
92TGFBR10.44896169
93ADRBK10.44848950
94CAMKK20.44615078
95PRKACA0.41324738
96CDK140.41223737
97DAPK30.39871339
98CDK180.39641450
99CDK11A0.39293280
100LMTK20.38470533

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.33061371
2Ribosome_Homo sapiens_hsa030103.86030381
3Parkinsons disease_Homo sapiens_hsa050123.64935980
4Protein export_Homo sapiens_hsa030603.37576177
5RNA polymerase_Homo sapiens_hsa030202.73488612
6Huntingtons disease_Homo sapiens_hsa050162.70972764
7Proteasome_Homo sapiens_hsa030502.57812468
8Alzheimers disease_Homo sapiens_hsa050102.44223766
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.28838300
10Homologous recombination_Homo sapiens_hsa034402.16890169
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.03776878
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.03665082
13Mismatch repair_Homo sapiens_hsa034301.97272259
14Cardiac muscle contraction_Homo sapiens_hsa042601.88334706
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.88014149
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.87681551
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.87004315
18Basal transcription factors_Homo sapiens_hsa030221.86442074
19Fanconi anemia pathway_Homo sapiens_hsa034601.81298378
20DNA replication_Homo sapiens_hsa030301.77857677
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.62525528
22Nucleotide excision repair_Homo sapiens_hsa034201.57719261
23Base excision repair_Homo sapiens_hsa034101.57020624
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.56887835
25Spliceosome_Homo sapiens_hsa030401.54733188
26RNA degradation_Homo sapiens_hsa030181.53498126
27Pyrimidine metabolism_Homo sapiens_hsa002401.50163431
28Propanoate metabolism_Homo sapiens_hsa006401.46349299
29One carbon pool by folate_Homo sapiens_hsa006701.45394114
30RNA transport_Homo sapiens_hsa030131.40113169
31Steroid biosynthesis_Homo sapiens_hsa001001.35119281
32Non-homologous end-joining_Homo sapiens_hsa034501.27167951
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26797858
34Collecting duct acid secretion_Homo sapiens_hsa049661.26577081
35Butanoate metabolism_Homo sapiens_hsa006501.22354119
36Nicotine addiction_Homo sapiens_hsa050331.18620973
37Pyruvate metabolism_Homo sapiens_hsa006201.17466100
38Phototransduction_Homo sapiens_hsa047441.14184939
39Sulfur relay system_Homo sapiens_hsa041221.13496059
40Folate biosynthesis_Homo sapiens_hsa007901.09249429
41Fatty acid elongation_Homo sapiens_hsa000621.09144696
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.08730058
43Purine metabolism_Homo sapiens_hsa002301.08653936
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.03129163
45Selenocompound metabolism_Homo sapiens_hsa004500.93632855
46Metabolic pathways_Homo sapiens_hsa011000.90392793
47Peroxisome_Homo sapiens_hsa041460.85178433
48Maturity onset diabetes of the young_Homo sapiens_hsa049500.83852202
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.81609815
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.79773502
51Regulation of autophagy_Homo sapiens_hsa041400.79203069
52Sulfur metabolism_Homo sapiens_hsa009200.73461759
53Cell cycle_Homo sapiens_hsa041100.73312941
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.71126955
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67203997
56Glutathione metabolism_Homo sapiens_hsa004800.64929410
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64382675
58Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61063803
59Taste transduction_Homo sapiens_hsa047420.59914121
60Carbon metabolism_Homo sapiens_hsa012000.59125810
61mRNA surveillance pathway_Homo sapiens_hsa030150.55326976
62Arginine and proline metabolism_Homo sapiens_hsa003300.54170107
63Tryptophan metabolism_Homo sapiens_hsa003800.53368479
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53190409
65Biosynthesis of amino acids_Homo sapiens_hsa012300.52821780
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51312704
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50430812
68Synaptic vesicle cycle_Homo sapiens_hsa047210.50391742
69Oocyte meiosis_Homo sapiens_hsa041140.50339085
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49956524
71Vibrio cholerae infection_Homo sapiens_hsa051100.49205198
72GABAergic synapse_Homo sapiens_hsa047270.48102174
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46141364
74Nitrogen metabolism_Homo sapiens_hsa009100.45628883
75N-Glycan biosynthesis_Homo sapiens_hsa005100.40246987
76Fatty acid metabolism_Homo sapiens_hsa012120.39977251
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39113894
78Linoleic acid metabolism_Homo sapiens_hsa005910.36692328
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.35554854
80Morphine addiction_Homo sapiens_hsa050320.34957260
81Hedgehog signaling pathway_Homo sapiens_hsa043400.34941494
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34830683
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34123883
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.34044289
85Ether lipid metabolism_Homo sapiens_hsa005650.33767908
86Chemical carcinogenesis_Homo sapiens_hsa052040.33177935
87p53 signaling pathway_Homo sapiens_hsa041150.32817013
88Alcoholism_Homo sapiens_hsa050340.29884223
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29756558
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.29660651
91Fatty acid degradation_Homo sapiens_hsa000710.29509427
92Basal cell carcinoma_Homo sapiens_hsa052170.29409162
93beta-Alanine metabolism_Homo sapiens_hsa004100.29076862
94Tyrosine metabolism_Homo sapiens_hsa003500.28778346
95Circadian rhythm_Homo sapiens_hsa047100.28577208
96Olfactory transduction_Homo sapiens_hsa047400.26541860
97Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.25499882
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24325190
99Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.23592616
100Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.22882546

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