C11ORF95

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)4.36661067
2cell migration in hindbrain (GO:0021535)4.15926111
3axonal fasciculation (GO:0007413)3.96584908
4axon extension (GO:0048675)3.95173296
5neuron recognition (GO:0008038)3.91799595
6neuron projection extension involved in neuron projection guidance (GO:1902284)3.82615768
7axon extension involved in axon guidance (GO:0048846)3.82615768
8postsynaptic membrane organization (GO:0001941)3.74377161
9presynaptic membrane organization (GO:0097090)3.62446518
10paraxial mesoderm development (GO:0048339)3.57134969
11presynaptic membrane assembly (GO:0097105)3.48362278
12dendritic spine morphogenesis (GO:0060997)3.35243032
13planar cell polarity pathway involved in neural tube closure (GO:0090179)3.34777588
14neuron projection extension (GO:1990138)3.32792932
15negative regulation of catenin import into nucleus (GO:0035414)3.29378377
16camera-type eye morphogenesis (GO:0048593)3.25225824
17nucleobase catabolic process (GO:0046113)3.18045589
18cranial nerve morphogenesis (GO:0021602)3.17947208
19ganglion development (GO:0061548)3.17455688
20central nervous system projection neuron axonogenesis (GO:0021952)3.11038995
21cerebral cortex radially oriented cell migration (GO:0021799)3.10282063
22regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.01506717
23regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.01276955
24establishment of mitochondrion localization (GO:0051654)2.99787491
25layer formation in cerebral cortex (GO:0021819)2.99278211
26convergent extension (GO:0060026)2.98685645
27spinal cord development (GO:0021510)2.93798269
28mitochondrion transport along microtubule (GO:0047497)2.90094264
29establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.90094264
30neuronal ion channel clustering (GO:0045161)2.82999301
31substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.80821671
32substrate-independent telencephalic tangential migration (GO:0021826)2.80821671
33cell proliferation in forebrain (GO:0021846)2.78750119
34neuron cell-cell adhesion (GO:0007158)2.78212553
35establishment of monopolar cell polarity (GO:0061162)2.77197821
36establishment or maintenance of monopolar cell polarity (GO:0061339)2.77197821
37retinal ganglion cell axon guidance (GO:0031290)2.74595618
38establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.74188090
39positive regulation of synapse assembly (GO:0051965)2.73555037
40regulation of axon extension involved in axon guidance (GO:0048841)2.71916789
41positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.70999960
42protein localization to synapse (GO:0035418)2.70145729
43regulation of axon guidance (GO:1902667)2.68203363
44heterochromatin organization (GO:0070828)2.66373910
45developmental cell growth (GO:0048588)2.65221473
46outer ear morphogenesis (GO:0042473)2.64471085
47lateral sprouting from an epithelium (GO:0060601)2.63277368
48dendrite morphogenesis (GO:0048813)2.62474755
49head development (GO:0060322)2.61557483
50olfactory bulb development (GO:0021772)2.57333108
51establishment of nucleus localization (GO:0040023)2.56193701
52negative regulation of axon extension involved in axon guidance (GO:0048843)2.56067263
53locomotory exploration behavior (GO:0035641)2.54469932
54regulation of short-term neuronal synaptic plasticity (GO:0048172)2.53376364
55negative regulation of axon guidance (GO:1902668)2.53210064
56exploration behavior (GO:0035640)2.53120783
57renal system development (GO:0072001)2.52579462
58dendrite development (GO:0016358)2.52054216
59body morphogenesis (GO:0010171)2.50776011
60regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.49912141
61lung-associated mesenchyme development (GO:0060484)2.49622780
62Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.49570156
63regulation of glycogen (starch) synthase activity (GO:2000465)2.47874245
64spinal cord association neuron differentiation (GO:0021527)2.43989919
65neuron migration (GO:0001764)2.42685963
66G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.41907712
67positive regulation of gastrulation (GO:2000543)2.40093210
68vocalization behavior (GO:0071625)2.38717277
69forebrain neuron differentiation (GO:0021879)2.38539859
70cochlea morphogenesis (GO:0090103)2.37880357
71peripheral nervous system axon ensheathment (GO:0032292)2.35748951
72myelination in peripheral nervous system (GO:0022011)2.35748951
73behavioral response to nicotine (GO:0035095)2.35672437
74tongue development (GO:0043586)2.34564777
75ephrin receptor signaling pathway (GO:0048013)2.34451316
76establishment of planar polarity (GO:0001736)2.34234041
77establishment of tissue polarity (GO:0007164)2.34234041
78kidney mesenchyme development (GO:0072074)2.33187821
79regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.33032722
80regulation of establishment of planar polarity (GO:0090175)2.33022992
81regulation of neuron migration (GO:2001222)2.30892183
82adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.30139407
83regulation of NFAT protein import into nucleus (GO:0051532)2.29452919
84neurotransmitter-gated ion channel clustering (GO:0072578)2.29288289
85axon ensheathment in central nervous system (GO:0032291)2.28211931
86central nervous system myelination (GO:0022010)2.28211931
87positive regulation of neuroblast proliferation (GO:0002052)2.27295603
88central nervous system neuron axonogenesis (GO:0021955)2.25992588
89embryonic retina morphogenesis in camera-type eye (GO:0060059)2.25536839
90metanephric mesenchyme development (GO:0072075)2.24887922
91auditory behavior (GO:0031223)2.24250943
92regulation of synapse assembly (GO:0051963)2.22551434
93heart valve formation (GO:0003188)2.20552907
94non-canonical Wnt signaling pathway (GO:0035567)2.20486300
95bone trabecula formation (GO:0060346)2.19947260
96artery development (GO:0060840)2.19914531
97apical protein localization (GO:0045176)2.19904761
98regulation of glutamate receptor signaling pathway (GO:1900449)2.19723147
99skeletal muscle organ development (GO:0060538)2.18516196
100establishment or maintenance of apical/basal cell polarity (GO:0035088)2.17353661

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.51143436
2EZH2_27304074_Chip-Seq_ESCs_Mouse3.25464625
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.11220724
4RBPJ_22232070_ChIP-Seq_NCS_Mouse2.95702878
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.90738147
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.84451407
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.84451407
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.78826661
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.76676914
10CBX2_27304074_Chip-Seq_ESCs_Mouse2.67079662
11RNF2_27304074_Chip-Seq_ESCs_Mouse2.63676403
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.49242113
13PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.39506775
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.36458774
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.35080451
16EZH2_27294783_Chip-Seq_ESCs_Mouse2.34187040
17SUZ12_27294783_Chip-Seq_ESCs_Mouse2.26575057
18SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.24016606
19EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.22520796
20SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.20224806
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.13195799
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.11499893
23TP53_20018659_ChIP-ChIP_R1E_Mouse2.09206386
24RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.08700772
25ERG_21242973_ChIP-ChIP_JURKAT_Human2.06553876
26SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.01544925
27EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.01131423
28RING1B_27294783_Chip-Seq_ESCs_Mouse1.94834158
29RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.92078042
30ZFP281_18757296_ChIP-ChIP_E14_Mouse1.91285090
31RING1B_27294783_Chip-Seq_NPCs_Mouse1.83564470
32SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.82675038
33REST_21632747_ChIP-Seq_MESCs_Mouse1.82370219
34OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.80972737
35MTF2_20144788_ChIP-Seq_MESCs_Mouse1.77371600
36WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.77160996
37ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.73090775
38ZFP281_27345836_Chip-Seq_ESCs_Mouse1.72727113
39TP63_19390658_ChIP-ChIP_HaCaT_Human1.70780708
40* KDM2B_26808549_Chip-Seq_K562_Human1.68426649
41SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.65328242
42TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.64378260
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.60437072
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.57723645
45RNF2_27304074_Chip-Seq_NSC_Mouse1.56988359
46REST_18959480_ChIP-ChIP_MESCs_Mouse1.47840823
47ISL1_27105846_Chip-Seq_CPCs_Mouse1.44326180
48* CTCF_27219007_Chip-Seq_Bcells_Human1.40223852
49GATA1_26923725_Chip-Seq_HPCs_Mouse1.38044360
50POU5F1_16153702_ChIP-ChIP_HESCs_Human1.36904408
51DROSHA_22980978_ChIP-Seq_HELA_Human1.35210330
52RARB_27405468_Chip-Seq_BRAIN_Mouse1.28545845
53AR_21572438_ChIP-Seq_LNCaP_Human1.23229361
54TRIM28_21343339_ChIP-Seq_HEK293_Human1.21799541
55GBX2_23144817_ChIP-Seq_PC3_Human1.21016729
56RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.19101885
57GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.18551759
58SOX2_18555785_ChIP-Seq_MESCs_Mouse1.13645849
59HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.13261565
60THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11704014
61WT1_19549856_ChIP-ChIP_CCG9911_Human1.11338816
62KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.11028005
63EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.07052476
64DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.05838097
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03954243
66WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03259876
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02955810
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02955810
69SOX2_16153702_ChIP-ChIP_HESCs_Human1.00545172
70STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.99911520
71* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.99528482
72SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.98588605
73TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.94843314
74MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.93600225
75SOX3_22085726_ChIP-Seq_NPCs_Mouse0.92923671
76DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92890183
77* KDM2B_26808549_Chip-Seq_JURKAT_Human0.91532114
78POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.91095543
79YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90399169
80IKZF1_21737484_ChIP-ChIP_HCT116_Human0.90252942
81TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90175966
82NFIB_24661679_ChIP-Seq_LUNG_Mouse0.89691821
83* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.87793672
84POU5F1_16518401_ChIP-PET_MESCs_Mouse0.85831147
85NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.85734981
86MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.85553973
87TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.85316428
88AR_19668381_ChIP-Seq_PC3_Human0.83838949
89SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.83716898
90TBX3_20139965_ChIP-Seq_MESCs_Mouse0.83064598
91KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.82986786
92* SMAD3_21741376_ChIP-Seq_ESCs_Human0.82432400
93TBX3_20139965_ChIP-Seq_ESCs_Mouse0.82239393
94SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.80338465
95FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.79844030
96SOX9_26525672_Chip-Seq_HEART_Mouse0.79212229
97MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.78825317
98TET1_21490601_ChIP-Seq_MESCs_Mouse0.76446961
99P53_22127205_ChIP-Seq_FIBROBLAST_Human0.76413023
100* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.76217159

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000778_abnormal_nervous_system2.82574607
2MP0000566_synostosis2.79349079
3MP0010030_abnormal_orbit_morphology2.69870327
4MP0004859_abnormal_synaptic_plasticity2.46262355
5MP0000537_abnormal_urethra_morphology2.13157646
6MP0003123_paternal_imprinting2.10178651
7MP0006292_abnormal_olfactory_placode2.05635664
8MP0003122_maternal_imprinting2.04048593
9MP0000049_abnormal_middle_ear2.03272583
10MP0005423_abnormal_somatic_nervous2.00685116
11MP0009379_abnormal_foot_pigmentation1.91772596
12MP0001299_abnormal_eye_distance/1.85675236
13MP0006276_abnormal_autonomic_nervous1.85446084
14MP0003880_abnormal_central_pattern1.84921040
15MP0003942_abnormal_urinary_system1.84785790
16MP0003890_abnormal_embryonic-extraembry1.77913820
17MP0002184_abnormal_innervation1.75953810
18MP0000534_abnormal_ureter_morphology1.75541853
19MP0003385_abnormal_body_wall1.74105060
20MP0005257_abnormal_intraocular_pressure1.73693314
21MP0009053_abnormal_anal_canal1.69434232
22MP0000955_abnormal_spinal_cord1.67169013
23MP0009250_abnormal_appendicular_skeleto1.58484917
24MP0004270_analgesia1.58474764
25MP0002249_abnormal_larynx_morphology1.56831700
26MP0001188_hyperpigmentation1.55262522
27MP0005394_taste/olfaction_phenotype1.55140744
28MP0005499_abnormal_olfactory_system1.55140744
29MP0003861_abnormal_nervous_system1.54567430
30MP0003635_abnormal_synaptic_transmissio1.54358441
31MP0003119_abnormal_digestive_system1.54218039
32MP0003787_abnormal_imprinting1.51533292
33MP0003121_genomic_imprinting1.50967782
34MP0003937_abnormal_limbs/digits/tail_de1.49733619
35MP0002233_abnormal_nose_morphology1.49485534
36MP0003283_abnormal_digestive_organ1.48058860
37MP0008789_abnormal_olfactory_epithelium1.46776217
38MP0003755_abnormal_palate_morphology1.40439242
39MP0003315_abnormal_perineum_morphology1.39562960
40MP0000428_abnormal_craniofacial_morphol1.38485250
41MP0003938_abnormal_ear_development1.36521197
42MP0001293_anophthalmia1.36179418
43MP0002697_abnormal_eye_size1.35910823
44MP0004133_heterotaxia1.35893755
45MP0002063_abnormal_learning/memory/cond1.34502633
46MP0005503_abnormal_tendon_morphology1.29661442
47MP0005409_darkened_coat_color1.29422797
48MP0010368_abnormal_lymphatic_system1.28550205
49MP0003705_abnormal_hypodermis_morpholog1.28495625
50MP0002152_abnormal_brain_morphology1.27857686
51MP0002116_abnormal_craniofacial_bone1.27204861
52MP0004858_abnormal_nervous_system1.26552479
53MP0002734_abnormal_mechanical_nocicepti1.26174290
54MP0008438_abnormal_cutaneous_collagen1.22475235
55MP0002092_abnormal_eye_morphology1.22288827
56MP0002882_abnormal_neuron_morphology1.21340837
57MP0004811_abnormal_neuron_physiology1.19566700
58MP0001346_abnormal_lacrimal_gland1.17335099
59MP0003935_abnormal_craniofacial_develop1.17290959
60MP0004272_abnormal_basement_membrane1.16825694
61MP0001286_abnormal_eye_development1.14999428
62MP0002752_abnormal_somatic_nervous1.11012346
63MP0004885_abnormal_endolymph1.09227392
64MP0002938_white_spotting1.08616748
65MP0002081_perinatal_lethality1.08252059
66MP0003136_yellow_coat_color1.07063045
67MP0002932_abnormal_joint_morphology1.06316693
68MP0002557_abnormal_social/conspecific_i1.05741683
69MP0005187_abnormal_penis_morphology1.05714424
70MP0002653_abnormal_ependyma_morphology1.05192093
71MP0002572_abnormal_emotion/affect_behav1.04863968
72MP0005623_abnormal_meninges_morphology1.03775678
73MP0000631_abnormal_neuroendocrine_gland1.03613784
74MP0001529_abnormal_vocalization1.03239888
75MP0000026_abnormal_inner_ear0.98604933
76MP0003115_abnormal_respiratory_system0.95497096
77MP0005248_abnormal_Harderian_gland0.95104299
78MP0000462_abnormal_digestive_system0.94543070
79MP0002751_abnormal_autonomic_nervous0.93442052
80MP0001984_abnormal_olfaction0.91243996
81MP0001879_abnormal_lymphatic_vessel0.89955842
82MP0000432_abnormal_head_morphology0.88326558
83MP0002272_abnormal_nervous_system0.86695716
84MP0002114_abnormal_axial_skeleton0.86552716
85MP0003567_abnormal_fetal_cardiomyocyte0.86340143
86MP0002822_catalepsy0.86293490
87MP0000762_abnormal_tongue_morphology0.85678618
88MP0002111_abnormal_tail_morphology0.84297307
89MP0002084_abnormal_developmental_patter0.81798801
90MP0005508_abnormal_skeleton_morphology0.81656958
91MP0009672_abnormal_birth_weight0.81063108
92MP0002085_abnormal_embryonic_tissue0.80868958
93MP0001502_abnormal_circadian_rhythm0.80668155
94MP0009384_cardiac_valve_regurgitation0.79644539
95MP0005391_vision/eye_phenotype0.79476006
96MP0001440_abnormal_grooming_behavior0.78529912
97MP0001177_atelectasis0.76318597
98MP0001970_abnormal_pain_threshold0.76043712
99MP0002735_abnormal_chemical_nociception0.76026501
100MP0005195_abnormal_posterior_eye0.75982775

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)3.18482456
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.18482456
3Turricephaly (HP:0000262)3.13371635
4Broad metatarsal (HP:0001783)2.89913082
5Shallow orbits (HP:0000586)2.83015634
6High anterior hairline (HP:0009890)2.78345418
7Coronal craniosynostosis (HP:0004440)2.77861978
8Abnormality of the 4th metacarpal (HP:0010012)2.67921325
9Abnormality of the aortic arch (HP:0012303)2.66697787
10Cutaneous finger syndactyly (HP:0010554)2.64476570
11Myokymia (HP:0002411)2.62690291
12Cutaneous syndactyly (HP:0012725)2.58785759
13Hepatoblastoma (HP:0002884)2.55770896
14Partial duplication of the phalanx of hand (HP:0009999)2.47613240
15Partial duplication of thumb phalanx (HP:0009944)2.41402166
16Aplasia involving bones of the upper limbs (HP:0009823)2.32819537
17Aplasia of the phalanges of the hand (HP:0009802)2.32819537
18Aplasia involving bones of the extremities (HP:0009825)2.32819537
19Shawl scrotum (HP:0000049)2.28469674
20Septo-optic dysplasia (HP:0100842)2.27952270
21Hypoventilation (HP:0002791)2.17599342
22Rib fusion (HP:0000902)2.11262561
23Hyperacusis (HP:0010780)2.05251949
24Renovascular hypertension (HP:0100817)2.04600726
25Vitreoretinal degeneration (HP:0000655)2.03503047
26Protrusio acetabuli (HP:0003179)2.01879306
27Abnormality of the labia minora (HP:0012880)2.01394290
28Megalencephaly (HP:0001355)2.00790124
29Bowel diverticulosis (HP:0005222)2.00407767
30Bladder diverticulum (HP:0000015)2.00163016
31Morphological abnormality of the middle ear (HP:0008609)1.98395674
32Renal duplication (HP:0000075)1.96102260
33Trigonocephaly (HP:0000243)1.92709117
34Overriding aorta (HP:0002623)1.91801858
35Genu recurvatum (HP:0002816)1.90122981
36Neonatal short-limb short stature (HP:0008921)1.89967669
37Broad thumb (HP:0011304)1.89396040
38Cortical dysplasia (HP:0002539)1.88855274
39Calcaneovalgus deformity (HP:0001848)1.87287505
40Overgrowth (HP:0001548)1.87112406
41Ulnar bowing (HP:0003031)1.86457686
42Wide anterior fontanel (HP:0000260)1.86359946
43Midline defect of the nose (HP:0004122)1.86084378
44Broad finger (HP:0001500)1.85798562
45Buphthalmos (HP:0000557)1.84559303
46Esophageal atresia (HP:0002032)1.84363171
47Broad long bones (HP:0005622)1.83987232
48Broad phalanges of the hand (HP:0009768)1.82299696
49Drooling (HP:0002307)1.82188758
50Premature rupture of membranes (HP:0001788)1.81585269
51Insomnia (HP:0100785)1.81478004
52Deep palmar crease (HP:0006191)1.81304180
53Abnormality of the phalanges of the hallux (HP:0010057)1.79068812
54Preaxial foot polydactyly (HP:0001841)1.78465332
55Broad phalanx (HP:0006009)1.77850560
56Arnold-Chiari malformation (HP:0002308)1.76177065
57Deformed tarsal bones (HP:0008119)1.75611544
58Elfin facies (HP:0004428)1.75362358
59Thin ribs (HP:0000883)1.74860380
60Megalocornea (HP:0000485)1.74135425
61Abnormality of dentin (HP:0010299)1.72688575
62Bronchomalacia (HP:0002780)1.67866234
63Abnormality of the diencephalon (HP:0010662)1.65953036
64Pointed chin (HP:0000307)1.65737071
65Anophthalmia (HP:0000528)1.65519675
66Sleep apnea (HP:0010535)1.64846362
67Abnormal number of incisors (HP:0011064)1.64704328
68Vertebral arch anomaly (HP:0008438)1.63371553
69Aplasia/Hypoplasia of the sternum (HP:0006714)1.63217352
70Aplasia/Hypoplasia of the brainstem (HP:0007362)1.62340170
71Hypoplasia of the brainstem (HP:0002365)1.62340170
72Choanal stenosis (HP:0000452)1.62325240
73Abnormality of the lower motor neuron (HP:0002366)1.58922183
74Spinal rigidity (HP:0003306)1.58715356
75Broad hallux (HP:0010055)1.58383904
76Narrow nasal bridge (HP:0000446)1.57877982
77Abnormality of the calcaneus (HP:0008364)1.56627449
78Excessive salivation (HP:0003781)1.55238234
79Deviation of the hallux (HP:0010051)1.54679453
80Hypoplasia of the maxilla (HP:0000327)1.54282598
81Abnormality of the antihelix (HP:0009738)1.51908653
82Broad toe (HP:0001837)1.51380548
83Duplication of thumb phalanx (HP:0009942)1.51195828
84Abnormality of the incisor (HP:0000676)1.50424753
85Flat cornea (HP:0007720)1.50319083
86Optic nerve hypoplasia (HP:0000609)1.49984839
87Enlarged penis (HP:0000040)1.49655589
88Renal dysplasia (HP:0000110)1.49263869
89Abnormality of the parietal bone (HP:0002696)1.48623452
90Abdominal situs inversus (HP:0003363)1.48109174
91Abnormality of abdominal situs (HP:0011620)1.48109174
92Short palpebral fissure (HP:0012745)1.46942525
93Obstructive sleep apnea (HP:0002870)1.46889280
94Omphalocele (HP:0001539)1.46792204
95Diastasis recti (HP:0001540)1.46115769
96Facial hemangioma (HP:0000329)1.45773927
97Hallux valgus (HP:0001822)1.45639538
98Spina bifida occulta (HP:0003298)1.45307801
99Exotropia (HP:0000577)1.44658734
100Skull defect (HP:0001362)1.44341546

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.30987381
2EPHB23.65413004
3CASK3.47967371
4LATS22.58075156
5NTRK22.32281767
6MAP3K102.28433052
7NTRK12.16042091
8DYRK22.11488503
9TYRO32.06102890
10ICK2.00037889
11PNCK1.99026152
12MAP3K91.73370626
13NTRK31.68777208
14LATS11.68603728
15TRIB31.63275236
16CAMK1G1.61474285
17FGFR21.55220102
18SGK2231.55186353
19SGK4941.55186353
20EPHA41.51995367
21PDGFRA1.49325612
22PINK11.48203160
23MAP2K71.44181279
24MINK11.38375326
25EEF2K1.36600995
26CAMK1D1.25559112
27SIK21.24414083
28DYRK31.19588356
29SGK21.17640697
30MAP3K41.17525076
31NEK21.15752568
32PRKD31.11377234
33DYRK1B1.11164317
34KSR11.09824302
35SGK31.07604162
36RPS6KA21.07568542
37MARK21.03912637
38DDR21.02294754
39TIE11.01434046
40CSNK1G20.99272278
41TNIK0.98211817
42STK38L0.97998397
43RIPK10.95707207
44MTOR0.93425220
45WNK40.92841627
46PRKCG0.92303843
47MKNK20.91356654
48PAK60.89829438
49PKN20.88940517
50SIK10.84121715
51CDK190.84068497
52UHMK10.83572330
53CDK50.82600982
54MKNK10.80616964
55BRAF0.77131920
56WNK30.73517803
57MAPK150.72947174
58MAPK130.72929070
59CDK140.69611715
60PTK20.68629552
61CAMK10.66855264
62MAP2K40.66738954
63CDK150.65804810
64CDK11A0.65493782
65STK110.62745014
66BCR0.61716662
67AKT30.61358107
68PDGFRB0.60747025
69PRKCH0.60637427
70CSNK1E0.60533788
71DYRK1A0.60485431
72CSNK1G30.60242808
73CSNK1G10.59716039
74CDK180.59066325
75WNK10.58750163
76PAK30.56648028
77CDC70.56265028
78RPS6KC10.54428475
79RPS6KL10.54428475
80DMPK0.53770450
81PKN10.53738088
82PAK20.53433888
83CSNK1A1L0.52648658
84IRAK20.50585886
85RPS6KA60.50344973
86CAMK40.50216693
87CDK30.47554912
88PRKAA10.47550751
89GSK3B0.45562772
90PHKG10.45356465
91PHKG20.45356465
92AURKA0.44322274
93CHEK20.43164559
94RET0.42677882
95AKT10.41668205
96PRKDC0.41063105
97PRKCZ0.40550856
98TAF10.39899368
99STK380.39697978
100SGK10.39206402

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052172.64485751
2Axon guidance_Homo sapiens_hsa043602.49573026
3Hedgehog signaling pathway_Homo sapiens_hsa043402.44898562
4Nicotine addiction_Homo sapiens_hsa050332.10427940
5Hippo signaling pathway_Homo sapiens_hsa043901.92990639
6Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.82816517
7Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.74202727
8Cocaine addiction_Homo sapiens_hsa050301.71320698
9Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.70492481
10Melanogenesis_Homo sapiens_hsa049161.70323218
11Wnt signaling pathway_Homo sapiens_hsa043101.68697568
12Circadian entrainment_Homo sapiens_hsa047131.57871347
13Gap junction_Homo sapiens_hsa045401.56429585
14Notch signaling pathway_Homo sapiens_hsa043301.56016222
15Glutamatergic synapse_Homo sapiens_hsa047241.55932220
16Dilated cardiomyopathy_Homo sapiens_hsa054141.51224789
17ECM-receptor interaction_Homo sapiens_hsa045121.47290303
18Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.46276814
19Dopaminergic synapse_Homo sapiens_hsa047281.43636985
20Cholinergic synapse_Homo sapiens_hsa047251.42830731
21GABAergic synapse_Homo sapiens_hsa047271.40224551
22Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.39560118
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.37725744
24Morphine addiction_Homo sapiens_hsa050321.33290411
25Endometrial cancer_Homo sapiens_hsa052131.29114419
26Cardiac muscle contraction_Homo sapiens_hsa042601.28540255
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.21552413
28Insulin secretion_Homo sapiens_hsa049111.16562297
29ErbB signaling pathway_Homo sapiens_hsa040121.16142052
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.16126071
31Colorectal cancer_Homo sapiens_hsa052101.14792439
32Long-term potentiation_Homo sapiens_hsa047201.13911655
33Amphetamine addiction_Homo sapiens_hsa050311.11171222
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.10783309
35Oxytocin signaling pathway_Homo sapiens_hsa049211.10350144
36Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.05228065
37Aldosterone synthesis and secretion_Homo sapiens_hsa049251.04846375
38Focal adhesion_Homo sapiens_hsa045101.04077232
39Long-term depression_Homo sapiens_hsa047301.02615895
40Glioma_Homo sapiens_hsa052141.02600264
41Melanoma_Homo sapiens_hsa052181.01691429
42MicroRNAs in cancer_Homo sapiens_hsa052060.98096949
43Thyroid hormone signaling pathway_Homo sapiens_hsa049190.96629813
44Rap1 signaling pathway_Homo sapiens_hsa040150.95921377
45Alcoholism_Homo sapiens_hsa050340.95256900
46Adherens junction_Homo sapiens_hsa045200.95067718
47cAMP signaling pathway_Homo sapiens_hsa040240.94174673
48Ribosome_Homo sapiens_hsa030100.93765155
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.93167228
50Estrogen signaling pathway_Homo sapiens_hsa049150.92631215
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.91206406
52Synaptic vesicle cycle_Homo sapiens_hsa047210.88299136
53GnRH signaling pathway_Homo sapiens_hsa049120.87720732
54cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87673097
55TGF-beta signaling pathway_Homo sapiens_hsa043500.86956331
56Protein digestion and absorption_Homo sapiens_hsa049740.84729361
57Pathways in cancer_Homo sapiens_hsa052000.84439097
58Longevity regulating pathway - mammal_Homo sapiens_hsa042110.84009536
59Ras signaling pathway_Homo sapiens_hsa040140.83436422
60Tight junction_Homo sapiens_hsa045300.83270614
61Lysine degradation_Homo sapiens_hsa003100.82954960
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.82718084
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.82683243
64Gastric acid secretion_Homo sapiens_hsa049710.81153891
65MAPK signaling pathway_Homo sapiens_hsa040100.75095806
66AMPK signaling pathway_Homo sapiens_hsa041520.75086631
67Steroid biosynthesis_Homo sapiens_hsa001000.74464570
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.73854471
69Proteoglycans in cancer_Homo sapiens_hsa052050.73256053
70Renin secretion_Homo sapiens_hsa049240.72351596
71Dorso-ventral axis formation_Homo sapiens_hsa043200.71149997
72VEGF signaling pathway_Homo sapiens_hsa043700.70564387
73Prion diseases_Homo sapiens_hsa050200.69883783
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69491805
75Serotonergic synapse_Homo sapiens_hsa047260.68950606
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68631854
77Central carbon metabolism in cancer_Homo sapiens_hsa052300.67654293
78PI3K-Akt signaling pathway_Homo sapiens_hsa041510.66858860
79Chronic myeloid leukemia_Homo sapiens_hsa052200.66540590
80Taste transduction_Homo sapiens_hsa047420.66496544
81Renal cell carcinoma_Homo sapiens_hsa052110.65038140
82mRNA surveillance pathway_Homo sapiens_hsa030150.64027914
83Thyroid hormone synthesis_Homo sapiens_hsa049180.63646925
84Calcium signaling pathway_Homo sapiens_hsa040200.62241097
85Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.60992243
86Prostate cancer_Homo sapiens_hsa052150.58907126
87Insulin signaling pathway_Homo sapiens_hsa049100.57630719
88Oocyte meiosis_Homo sapiens_hsa041140.56752385
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56308529
90Olfactory transduction_Homo sapiens_hsa047400.56191306
91Phototransduction_Homo sapiens_hsa047440.55883067
92Cell cycle_Homo sapiens_hsa041100.54748325
93Salivary secretion_Homo sapiens_hsa049700.53929967
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53903503
95Sulfur relay system_Homo sapiens_hsa041220.53886915
96Type II diabetes mellitus_Homo sapiens_hsa049300.53814494
97Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.53402395
98Choline metabolism in cancer_Homo sapiens_hsa052310.53173604
99Glucagon signaling pathway_Homo sapiens_hsa049220.51929890
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49968923

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