C11ORF94

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to ATP (GO:0071318)9.59386554
2negative regulation of cell aging (GO:0090344)8.70239668
3DNA strand renaturation (GO:0000733)8.46167550
4adenosine receptor signaling pathway (GO:0001973)8.21813428
5GDP-mannose metabolic process (GO:0019673)8.19999612
6regulation of skeletal muscle contraction (GO:0014819)7.87770047
7meiotic chromosome segregation (GO:0045132)7.27619293
8G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)7.12866001
9peptidyl-glutamic acid carboxylation (GO:0017187)6.88304698
10protein carboxylation (GO:0018214)6.88304698
11rRNA methylation (GO:0031167)6.63512856
12purinergic nucleotide receptor signaling pathway (GO:0035590)6.62714908
13regulation of synapse structural plasticity (GO:0051823)6.59788961
14sensory perception of taste (GO:0050909)6.48413100
15lens fiber cell differentiation (GO:0070306)6.43703936
16mitotic cell cycle arrest (GO:0071850)6.30557910
17negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)5.86551372
18rRNA modification (GO:0000154)5.70588178
19regulation of cytokine production involved in inflammatory response (GO:1900015)5.32878608
20response to ATP (GO:0033198)5.23551020
21positive regulation of protein kinase C signaling (GO:0090037)5.22161958
22adenine nucleotide transport (GO:0051503)5.04303646
23purine ribonucleotide transport (GO:0015868)5.01968275
24purinergic receptor signaling pathway (GO:0035587)4.96412632
25urinary tract smooth muscle contraction (GO:0014848)4.90093819
26behavioral response to nicotine (GO:0035095)4.84004541
27estrogen biosynthetic process (GO:0006703)4.75892654
28regulation of protein kinase A signaling (GO:0010738)4.50024858
29detection of light stimulus involved in sensory perception (GO:0050962)4.46461783
30detection of light stimulus involved in visual perception (GO:0050908)4.46461783
31G-protein coupled purinergic receptor signaling pathway (GO:0035588)4.44605928
32UV protection (GO:0009650)4.43804001
33transepithelial transport (GO:0070633)4.38981634
34positive regulation of megakaryocyte differentiation (GO:0045654)4.37492744
35positive regulation of heat generation (GO:0031652)4.27140528
36peristalsis (GO:0030432)4.19182577
37nucleoside transmembrane transport (GO:1901642)4.18055531
38melanin biosynthetic process (GO:0042438)4.14483436
39regulation of cell aging (GO:0090342)4.09613849
40neuromuscular synaptic transmission (GO:0007274)3.98794039
41mannose metabolic process (GO:0006013)3.92639901
42melanin metabolic process (GO:0006582)3.89037270
43purine nucleotide transport (GO:0015865)3.88865961
44protein import into peroxisome matrix (GO:0016558)3.88020310
45granulocyte differentiation (GO:0030851)3.87401283
46nucleotide transmembrane transport (GO:1901679)3.86765315
47semaphorin-plexin signaling pathway (GO:0071526)3.81860402
48protein retention in ER lumen (GO:0006621)3.76348131
49protein insertion into membrane (GO:0051205)3.74856508
50nucleotide-sugar biosynthetic process (GO:0009226)3.72398435
51positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.71363551
52sex determination (GO:0007530)3.65611453
53mitochondrion distribution (GO:0048311)3.58166124
54regulation of phospholipid biosynthetic process (GO:0071071)3.57652120
55negative regulation of interleukin-8 production (GO:0032717)3.56686576
56cell migration in hindbrain (GO:0021535)3.56410951
57histone phosphorylation (GO:0016572)3.54157929
58sialylation (GO:0097503)3.46382053
59endocytic recycling (GO:0032456)3.45021749
60sphingosine metabolic process (GO:0006670)3.39861231
61grooming behavior (GO:0007625)3.35592164
62type B pancreatic cell proliferation (GO:0044342)3.35175934
63sphingomyelin metabolic process (GO:0006684)3.34672755
64interferon-gamma production (GO:0032609)3.31822557
65phosphatidylglycerol biosynthetic process (GO:0006655)3.31145750
66activation of adenylate cyclase activity (GO:0007190)3.30529174
67purine nucleoside bisphosphate biosynthetic process (GO:0034033)3.28638679
68ribonucleoside bisphosphate biosynthetic process (GO:0034030)3.28638679
69nucleoside bisphosphate biosynthetic process (GO:0033866)3.28638679
70peptidyl-glutamic acid modification (GO:0018200)3.28551846
71gonadal mesoderm development (GO:0007506)3.27014497
72DNA replication checkpoint (GO:0000076)3.22472174
73sulfur amino acid catabolic process (GO:0000098)3.22127694
74maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.19118929
75iron coordination entity transport (GO:1901678)3.16138277
76folic acid metabolic process (GO:0046655)3.16095828
77tRNA modification (GO:0006400)3.15038202
78positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.13265230
79regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)3.09432334
80positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.09100310
81secondary metabolite biosynthetic process (GO:0044550)3.08332795
82diol metabolic process (GO:0034311)3.08180291
83cellular anion homeostasis (GO:0030002)3.02687222
84phosphatidylethanolamine biosynthetic process (GO:0006646)3.02526805
85regulation of nuclear cell cycle DNA replication (GO:0033262)3.02312278
86cardiolipin metabolic process (GO:0032048)3.01629688
87cilium or flagellum-dependent cell motility (GO:0001539)3.01052517
88regulation of heat generation (GO:0031650)3.00741735
89snRNA transcription (GO:0009301)3.00636425
90DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.90647119
91trivalent inorganic anion homeostasis (GO:0072506)2.89714745
92phosphate ion homeostasis (GO:0055062)2.89714745
93nucleoside transport (GO:0015858)2.88139412
94microtubule depolymerization (GO:0007019)2.85823326
95phosphate ion transmembrane transport (GO:0035435)2.85488763
96positive regulation of adenylate cyclase activity (GO:0045762)2.85400646
97tachykinin receptor signaling pathway (GO:0007217)2.85389514
98ribosomal small subunit biogenesis (GO:0042274)2.84576016
99DNA duplex unwinding (GO:0032508)2.84390063
100positive regulation of blood pressure (GO:0045777)2.84332780

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human4.38900085
2STAT6_21828071_ChIP-Seq_BEAS2B_Human4.13537028
3TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse3.16099108
4LXR_22292898_ChIP-Seq_THP-1_Human3.13457982
5P68_20966046_ChIP-Seq_HELA_Human3.06105651
6XRN2_22483619_ChIP-Seq_HELA_Human2.63018495
7EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.54933770
8CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.53510632
9MAF_26560356_Chip-Seq_TH2_Human2.47875991
10E2F1_20622854_ChIP-Seq_HELA_Human2.37629525
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.35689797
12DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.34254501
13BCOR_27268052_Chip-Seq_Bcells_Human2.29133760
14* CTCF_27219007_Chip-Seq_Bcells_Human2.28804490
15MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human2.23195377
16PHF8_20622854_ChIP-Seq_HELA_Human2.22215167
17BCL6_27268052_Chip-Seq_Bcells_Human2.20212192
18ERG_21242973_ChIP-ChIP_JURKAT_Human2.20073199
19RACK7_27058665_Chip-Seq_MCF-7_Human2.14999193
20VDR_24763502_ChIP-Seq_THP-1_Human2.13316302
21TET1_21451524_ChIP-Seq_MESCs_Mouse2.12896000
22CTCF_27219007_Chip-Seq_ERYTHROID_Human2.10936204
23ELF1_20517297_ChIP-Seq_JURKAT_Human1.97911760
24RARA_24833708_ChIP-Seq_LIVER_Mouse1.95618746
25MYC_22102868_ChIP-Seq_BL_Human1.94349848
26RARB_24833708_ChIP-Seq_LIVER_Mouse1.94165892
27* MAF_26560356_Chip-Seq_TH1_Human1.89707999
28KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.88163008
29CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.84021155
30CTCF_21964334_Chip-Seq_Bcells_Human1.83926075
31KDM2B_26808549_Chip-Seq_SUP-B15_Human1.83636834
32TP53_22127205_ChIP-Seq_IMR90_Human1.82032990
33RXRA_24833708_ChIP-Seq_LIVER_Mouse1.81929268
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.81273568
35SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.81089911
36* SMC4_20622854_ChIP-Seq_HELA_Human1.80873552
37FOXP1_21924763_ChIP-Seq_HESCs_Human1.80568581
38SA1_27219007_Chip-Seq_ERYTHROID_Human1.74505396
39TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.71236609
40KDM2B_26808549_Chip-Seq_DND41_Human1.66959519
41SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.65963525
42DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.64273313
43YY1_22570637_ChIP-Seq_MALME-3M_Human1.62242909
44CREB1_26743006_Chip-Seq_LNCaP_Human1.60991879
45SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.59122673
46ELK3_25401928_ChIP-Seq_HUVEC_Human1.58692305
47TP63_19390658_ChIP-ChIP_HaCaT_Human1.51860094
48SRY_22984422_ChIP-ChIP_TESTIS_Rat1.51833520
49UTX_26944678_Chip-Seq_JUKART_Human1.51570278
50SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50223273
51CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.49112286
52EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.48234561
53FOXM1_23109430_ChIP-Seq_U2OS_Human1.48099576
54TCF7_22412390_ChIP-Seq_EML_Mouse1.47992713
55CTCF_21964334_ChIP-Seq_BJAB-B_Human1.45824743
56FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.45710555
57CTCF_20526341_ChIP-Seq_ESCs_Human1.43942241
58JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.42948145
59RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.42187390
60CIITA_25753668_ChIP-Seq_RAJI_Human1.40368669
61ERA_21632823_ChIP-Seq_H3396_Human1.35132016
62ETS1_21867929_ChIP-Seq_TH2_Mouse1.35035697
63ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.34219440
64SA1_27219007_Chip-Seq_Bcells_Human1.34020937
65UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.33325357
66DNAJC2_21179169_ChIP-ChIP_NT2_Human1.32883924
67EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.30463351
68CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.26926096
69E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.24446987
70PU.1_20513432_ChIP-Seq_Bcells_Mouse1.23590744
71NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.20481304
72KDM2B_26808549_Chip-Seq_K562_Human1.20283427
73NCOR1_26117541_ChIP-Seq_K562_Human1.20224829
74ATF3_27146783_Chip-Seq_COLON_Human1.19790824
75JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.17884451
76BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.17787811
77RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.15811866
78PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14861554
79MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.14121350
80* UBF1/2_26484160_Chip-Seq_HMECs_Human1.11961839
81P300_27268052_Chip-Seq_Bcells_Human1.11455739
82CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.10897164
83CTCF_26484167_Chip-Seq_Bcells_Mouse1.10682911
84HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.09320158
85KDM2B_26808549_Chip-Seq_JURKAT_Human1.08645081
86MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.06060253
87OCT4_19829295_ChIP-Seq_ESCs_Human1.05414890
88FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.04902227
89SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.04634834
90CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.04469713
91E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03736109
92GABP_19822575_ChIP-Seq_HepG2_Human1.03629209
93TP63_17297297_ChIP-ChIP_HaCaT_Human1.03469312
94DCP1A_22483619_ChIP-Seq_HELA_Human1.02962844
95SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.02470857
96SMC3_22415368_ChIP-Seq_MEFs_Mouse1.01005616
97* TP63_22573176_ChIP-Seq_HFKS_Human1.00579708
98TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.99620166
99PKCTHETA_26484144_Chip-Seq_BREAST_Human0.97765128
100GATA3_21867929_ChIP-Seq_CD8_Mouse0.97587360

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation7.14770191
2MP0005174_abnormal_tail_pigmentation6.73976875
3MP0001986_abnormal_taste_sensitivity6.20272982
4MP0005423_abnormal_somatic_nervous5.88074118
5MP0003136_yellow_coat_color4.77126149
6MP0001188_hyperpigmentation3.79391893
7MP0005409_darkened_coat_color3.51121395
8MP0005083_abnormal_biliary_tract3.20096663
9MP0001968_abnormal_touch/_nociception2.89586346
10MP0000015_abnormal_ear_pigmentation2.60188744
11MP0000751_myopathy2.40499421
12MP0001756_abnormal_urination2.28332033
13MP0001502_abnormal_circadian_rhythm2.17068724
14MP0003705_abnormal_hypodermis_morpholog2.05988754
15MP0008875_abnormal_xenobiotic_pharmacok2.04522067
16MP0001661_extended_life_span2.02047197
17MP0003453_abnormal_keratinocyte_physiol1.96262696
18MP0002638_abnormal_pupillary_reflex1.95019822
19MP0002160_abnormal_reproductive_system1.88125142
20MP0002736_abnormal_nociception_after1.87317737
21MP0005410_abnormal_fertilization1.84818562
22MP0004381_abnormal_hair_follicle1.83975142
23MP0003111_abnormal_nucleus_morphology1.67403325
24MP0000538_abnormal_urinary_bladder1.53635595
25MP0000750_abnormal_muscle_regeneration1.52623216
26MP0004130_abnormal_muscle_cell1.46859673
27MP0002735_abnormal_chemical_nociception1.44939899
28MP0005058_abnormal_lysosome_morphology1.36543825
29MP0005501_abnormal_skin_physiology1.36320006
30MP0000747_muscle_weakness1.28369528
31MP0003693_abnormal_embryo_hatching1.24089773
32MP0005330_cardiomyopathy1.22920180
33MP0000013_abnormal_adipose_tissue1.16390144
34MP0005332_abnormal_amino_acid1.11945892
35MP0009053_abnormal_anal_canal1.08629844
36MP0000003_abnormal_adipose_tissue1.08285292
37MP0003879_abnormal_hair_cell1.06519011
38MP0005377_hearing/vestibular/ear_phenot0.96803708
39MP0003878_abnormal_ear_physiology0.96803708
40MP0005365_abnormal_bile_salt0.96551103
41MP0003077_abnormal_cell_cycle0.95172864
42MP0000470_abnormal_stomach_morphology0.94033877
43MP0005076_abnormal_cell_differentiation0.93361680
44MP0005551_abnormal_eye_electrophysiolog0.91512632
45MP0001765_abnormal_ion_homeostasis0.88263653
46MP0005584_abnormal_enzyme/coenzyme_acti0.87978082
47MP0009840_abnormal_foam_cell0.86102541
48MP0004957_abnormal_blastocyst_morpholog0.84363358
49MP0003806_abnormal_nucleotide_metabolis0.84191163
50MP0000516_abnormal_urinary_system0.83383573
51MP0005367_renal/urinary_system_phenotyp0.83383573
52MP0001919_abnormal_reproductive_system0.82095039
53MP0010094_abnormal_chromosome_stability0.81336465
54MP0002909_abnormal_adrenal_gland0.79529840
55MP0001348_abnormal_lacrimal_gland0.78229987
56MP0001664_abnormal_digestion0.78078362
57MP0005257_abnormal_intraocular_pressure0.75467238
58MP0000367_abnormal_coat/_hair0.74401504
59MP0001970_abnormal_pain_threshold0.73479978
60MP0004043_abnormal_pH_regulation0.72969588
61MP0005220_abnormal_exocrine_pancreas0.72168556
62MP0002928_abnormal_bile_duct0.71499452
63MP0010771_integument_phenotype0.71250084
64MP0009278_abnormal_bone_marrow0.70374828
65MP0009931_abnormal_skin_appearance0.69929382
66MP0005389_reproductive_system_phenotype0.68478673
67MP0003091_abnormal_cell_migration0.68437430
68MP0003448_altered_tumor_morphology0.68123197
69MP0001958_emphysema0.67818509
70MP0000778_abnormal_nervous_system0.65875718
71MP0005623_abnormal_meninges_morphology0.63242686
72MP0005084_abnormal_gallbladder_morpholo0.62841607
73MP0001905_abnormal_dopamine_level0.60846979
74MP0009379_abnormal_foot_pigmentation0.60690757
75MP0000358_abnormal_cell_content/0.59937294
76MP0004019_abnormal_vitamin_homeostasis0.58522818
77MP0002019_abnormal_tumor_incidence0.58376374
78MP0010386_abnormal_urinary_bladder0.57925752
79MP0009643_abnormal_urine_homeostasis0.57343074
80MP0003303_peritoneal_inflammation0.56944004
81MP0005253_abnormal_eye_physiology0.55219639
82MP0004185_abnormal_adipocyte_glucose0.53670819
83MP0003315_abnormal_perineum_morphology0.51608026
84MP0003137_abnormal_impulse_conducting0.50649989
85MP0003172_abnormal_lysosome_physiology0.50324004
86MP0001324_abnormal_eye_pigmentation0.50143030
87MP0002254_reproductive_system_inflammat0.49939400
88MP0003698_abnormal_male_reproductive0.48141719
89MP0002210_abnormal_sex_determination0.47863859
90MP0004197_abnormal_fetal_growth/weight/0.47100870
91MP0008874_decreased_physiological_sensi0.46965030
92MP0002136_abnormal_kidney_physiology0.45784581
93MP0002075_abnormal_coat/hair_pigmentati0.45646355
94MP0008770_decreased_survivor_rate0.43898185
95MP0001873_stomach_inflammation0.39952717
96MP0005375_adipose_tissue_phenotype0.39686101
97MP0001191_abnormal_skin_condition0.38778158
98MP0004087_abnormal_muscle_fiber0.38071988
99MP0002095_abnormal_skin_pigmentation0.37465572
100MP0003385_abnormal_body_wall0.34624006

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)6.50097164
2Testicular atrophy (HP:0000029)6.17652900
3Rectovaginal fistula (HP:0000143)5.74677424
4Rectal fistula (HP:0100590)5.74677424
5Thin bony cortex (HP:0002753)5.72960880
6Intestinal fistula (HP:0100819)5.38499923
7Poikiloderma (HP:0001029)5.25113782
8Vaginal fistula (HP:0004320)5.25021638
9Attenuation of retinal blood vessels (HP:0007843)5.07712131
10Dyschromatopsia (HP:0007641)4.96191126
11Facial hemangioma (HP:0000329)4.90736916
12Annular pancreas (HP:0001734)4.70867954
13Ulnar bowing (HP:0003031)4.62116392
14Abnormality of the intrinsic pathway (HP:0010989)4.38056720
15Popliteal pterygium (HP:0009756)4.31704882
16Turricephaly (HP:0000262)4.22300688
17Hemorrhage of the eye (HP:0011885)4.09707812
18Fetal akinesia sequence (HP:0001989)4.05318074
19Bony spicule pigmentary retinopathy (HP:0007737)4.03423121
20Mesangial abnormality (HP:0001966)4.01189858
21Aplasia/Hypoplasia involving the carpal bones (HP:0006502)4.00418609
22Delayed epiphyseal ossification (HP:0002663)3.94355638
23Coronal craniosynostosis (HP:0004440)3.88286635
24Facial diplegia (HP:0001349)3.88249673
25Akinesia (HP:0002304)3.85544337
26Congenital stationary night blindness (HP:0007642)3.81996035
27Joint hemorrhage (HP:0005261)3.78939043
28Squamous cell carcinoma (HP:0002860)3.78001976
29Aplasia of the musculature (HP:0100854)3.66513937
30Prolonged partial thromboplastin time (HP:0003645)3.64964322
31Chorioretinal atrophy (HP:0000533)3.61651793
32Anteriorly placed anus (HP:0001545)3.59348362
33Enlarged epiphyses (HP:0010580)3.58330751
34Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.37416622
35Short chin (HP:0000331)3.34510248
36Patellar aplasia (HP:0006443)3.28372866
37Hypophosphatemic rickets (HP:0004912)3.20824277
38Choroideremia (HP:0001139)3.17612013
39Abnormality of placental membranes (HP:0011409)3.10862369
40Amniotic constriction ring (HP:0009775)3.10862369
41Renal Fanconi syndrome (HP:0001994)3.09273352
42Capillary hemangiomas (HP:0005306)3.08296225
43Abnormality of the costochondral junction (HP:0000919)3.03096205
44Aplasia/Hypoplasia of the patella (HP:0006498)3.02828799
45Atrioventricular block (HP:0001678)3.02200163
46Increased hepatocellular lipid droplets (HP:0006565)2.98306856
47Lipid accumulation in hepatocytes (HP:0006561)2.89875966
48Absent thumb (HP:0009777)2.77940853
49Abnormal albumin level (HP:0012116)2.72827576
50Hypoalbuminemia (HP:0003073)2.72827576
51Bowed forearm bones (HP:0003956)2.70528862
52Bowing of the arm (HP:0006488)2.70528862
53Flat occiput (HP:0005469)2.63686611
54Decreased electroretinogram (ERG) amplitude (HP:0000654)2.62380524
55Joint stiffness (HP:0001387)2.60952328
56Widely patent fontanelles and sutures (HP:0004492)2.55348521
57Myotonia (HP:0002486)2.54368535
58Premature graying of hair (HP:0002216)2.44433514
59Male infertility (HP:0003251)2.41988711
60Zonular cataract (HP:0010920)2.40520351
61Birth length less than 3rd percentile (HP:0003561)2.39605894
62Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.39404662
63Neonatal onset (HP:0003623)2.37415211
64Decreased central vision (HP:0007663)2.37234300
65Abnormal epiphyseal ossification (HP:0010656)2.35795918
66Abnormality of the common coagulation pathway (HP:0010990)2.29073563
67Choanal stenosis (HP:0000452)2.27425928
68Basal cell carcinoma (HP:0002671)2.27392876
69Increased number of teeth (HP:0011069)2.22561444
70Narrow nasal bridge (HP:0000446)2.20839388
71Pendular nystagmus (HP:0012043)2.19754445
72Increased intramyocellular lipid droplets (HP:0012240)2.18181292
73Neonatal respiratory distress (HP:0002643)2.16911987
74Aplasia/Hypoplasia involving the musculature (HP:0001460)2.15431602
75Increased muscle lipid content (HP:0009058)2.15076522
76Short humerus (HP:0005792)2.15046355
77Thin ribs (HP:0000883)2.10195616
78Myopathic facies (HP:0002058)2.09798255
79Cystic hygroma (HP:0000476)2.08606293
80Hypoplasia of the radius (HP:0002984)2.07473009
81Abnormality of the hepatic vasculature (HP:0006707)2.05840682
82Spina bifida occulta (HP:0003298)2.05009897
83Abnormal urine phosphate concentration (HP:0012599)2.03626691
84Thrombocytosis (HP:0001894)2.03201030
85Breast hypoplasia (HP:0003187)2.01332803
86Malignant hyperthermia (HP:0002047)1.97590985
87Aplasia/hypoplasia of the humerus (HP:0006507)1.97379402
88Short thumb (HP:0009778)1.93443518
89Pterygium (HP:0001059)1.92031469
90Epiphyseal stippling (HP:0010655)1.90998468
91Fatigable weakness (HP:0003473)1.90607735
92Abnormality of the neuromuscular junction (HP:0003398)1.90607735
93Spontaneous abortion (HP:0005268)1.87534507
94Vertebral clefting (HP:0008428)1.85760892
95Abnormal trabecular bone morphology (HP:0100671)1.83277930
96Muscle fiber atrophy (HP:0100295)1.83107896
97Type 2 muscle fiber atrophy (HP:0003554)1.78730297
98Absent radius (HP:0003974)1.78383439
99Cheilitis (HP:0100825)1.76465685
100Exertional dyspnea (HP:0002875)1.74528823

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK159.38124755
2WNK44.15048203
3BLK3.55872949
4PIM23.15416811
5IRAK23.10269434
6MUSK2.93099803
7TRIB32.68635788
8TLK12.63845448
9TESK22.40149740
10DYRK1B1.94530686
11SIK21.75873954
12SIK11.72292384
13GRK61.69544466
14ERN11.56219632
15EPHB21.51010434
16PDPK11.49290355
17ZAK1.48083214
18STK161.44211230
19PRKD21.40815986
20RPS6KA21.37938967
21CDK61.34328283
22WNK11.31415328
23MAP2K31.24598000
24BRAF1.22308619
25CDK41.20165093
26ZAP701.17628312
27IRAK31.05796737
28ICK1.03652961
29ADRBK10.97532775
30AKT30.95569298
31EEF2K0.93346044
32RPS6KL10.90610312
33RPS6KC10.90610312
34MTOR0.90523094
35ARAF0.89809589
36BMX0.89371410
37CDK150.89162907
38RPS6KA60.88249748
39CDK11A0.87145483
40ADRBK20.85861493
41CSK0.81841016
42PRKD30.81502855
43CDK180.81496565
44TAOK10.81070755
45CCNB10.79194608
46NEK20.77215624
47AURKA0.76133548
48MINK10.75674783
49CDK140.75017896
50PRKD10.68952539
51MST1R0.66062705
52MAPK110.65022444
53MAPK80.62574193
54STK110.61106861
55CHEK20.56267465
56CAMK1D0.56038775
57SGK2230.55196368
58SGK4940.55196368
59DYRK30.54662924
60PRKCH0.53829069
61TYRO30.53484209
62CSNK1D0.53408844
63DAPK30.53049874
64DDR20.52947698
65PAK10.51855648
66CAMK1G0.51778125
67MAP2K40.50991669
68MARK20.50546369
69TBK10.48205107
70MAP2K60.48049288
71ACVR1B0.47054973
72RPS6KA50.43754052
73CDK120.43298305
74MAP2K70.41015346
75ATR0.39979166
76MAP2K20.39958944
77IKBKB0.38421749
78EPHA20.37679698
79AKT20.35540703
80MAPK120.34055598
81TRIM280.33468699
82PKN20.33264833
83PDK10.33091452
84MAP3K100.29324073
85CDK10.28174697
86CDK20.26820763
87GSK3B0.25617036
88HIPK20.24637718
89PIM10.23905512
90RIPK10.23563559
91RPS6KA10.22845021
92MAPK140.22830168
93ERBB20.22807559
94RAF10.22737328
95CAMK10.22095118
96PDGFRB0.21675218
97AKT10.20761415
98TIE10.20603440
99PRKAA10.20201315
100NTRK30.19041638

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006047.80391394
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001306.14393238
3Sulfur relay system_Homo sapiens_hsa041225.75800543
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.44287021
5Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.23715424
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.76135861
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.44389959
8Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.35273529
9Fructose and mannose metabolism_Homo sapiens_hsa000512.33270012
10Sphingolipid metabolism_Homo sapiens_hsa006001.93642647
11Circadian rhythm_Homo sapiens_hsa047101.62139566
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.62116634
13Hedgehog signaling pathway_Homo sapiens_hsa043401.52099461
14Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.47310907
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.38949982
16Fanconi anemia pathway_Homo sapiens_hsa034601.35642350
17Taste transduction_Homo sapiens_hsa047421.30652015
18Bladder cancer_Homo sapiens_hsa052191.25659330
19mTOR signaling pathway_Homo sapiens_hsa041501.23627629
20Other glycan degradation_Homo sapiens_hsa005111.14825638
21Nicotine addiction_Homo sapiens_hsa050331.14808302
22Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.08052865
23Alcoholism_Homo sapiens_hsa050341.04700700
24Inositol phosphate metabolism_Homo sapiens_hsa005620.94997056
25VEGF signaling pathway_Homo sapiens_hsa043700.93257333
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.90196655
27Lysine degradation_Homo sapiens_hsa003100.85805551
28Lysosome_Homo sapiens_hsa041420.83893844
29Vitamin digestion and absorption_Homo sapiens_hsa049770.83241242
30Base excision repair_Homo sapiens_hsa034100.82134138
31Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78223600
32Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.74249061
33Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70608215
34Ovarian steroidogenesis_Homo sapiens_hsa049130.69918763
35Notch signaling pathway_Homo sapiens_hsa043300.69036445
36Systemic lupus erythematosus_Homo sapiens_hsa053220.63269444
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60315435
38Axon guidance_Homo sapiens_hsa043600.59663549
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59211963
40Neurotrophin signaling pathway_Homo sapiens_hsa047220.58583610
41Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56885912
42Hippo signaling pathway_Homo sapiens_hsa043900.55883634
43Pyruvate metabolism_Homo sapiens_hsa006200.54299163
44Melanogenesis_Homo sapiens_hsa049160.53596876
45Non-small cell lung cancer_Homo sapiens_hsa052230.52955217
46Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52666271
47Cocaine addiction_Homo sapiens_hsa050300.51715337
48Calcium signaling pathway_Homo sapiens_hsa040200.51119919
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50732632
50Endocytosis_Homo sapiens_hsa041440.50597520
51Chronic myeloid leukemia_Homo sapiens_hsa052200.49009259
52Renin-angiotensin system_Homo sapiens_hsa046140.47219360
53Cell cycle_Homo sapiens_hsa041100.45144429
54Basal transcription factors_Homo sapiens_hsa030220.44923202
55Insulin resistance_Homo sapiens_hsa049310.44734809
56Dorso-ventral axis formation_Homo sapiens_hsa043200.43839480
57Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42396994
58Gap junction_Homo sapiens_hsa045400.40980062
59Glycerophospholipid metabolism_Homo sapiens_hsa005640.39574436
60Acute myeloid leukemia_Homo sapiens_hsa052210.39282039
61Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33288718
62ErbB signaling pathway_Homo sapiens_hsa040120.32253323
63RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.32105759
64N-Glycan biosynthesis_Homo sapiens_hsa005100.30575136
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.30385795
66Hepatitis C_Homo sapiens_hsa051600.29724524
67Viral carcinogenesis_Homo sapiens_hsa052030.28853015
68Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.27519686
69Insulin signaling pathway_Homo sapiens_hsa049100.27498843
70MAPK signaling pathway_Homo sapiens_hsa040100.25798033
71Glioma_Homo sapiens_hsa052140.24008571
72Endometrial cancer_Homo sapiens_hsa052130.23860314
73Apoptosis_Homo sapiens_hsa042100.23786046
74Basal cell carcinoma_Homo sapiens_hsa052170.22963326
75Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.22500930
76Jak-STAT signaling pathway_Homo sapiens_hsa046300.21726915
772-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.21658370
78Cholinergic synapse_Homo sapiens_hsa047250.21546387
79Hematopoietic cell lineage_Homo sapiens_hsa046400.20948746
80Aldosterone synthesis and secretion_Homo sapiens_hsa049250.20659863
81Pyrimidine metabolism_Homo sapiens_hsa002400.19454250
82B cell receptor signaling pathway_Homo sapiens_hsa046620.19284244
83p53 signaling pathway_Homo sapiens_hsa041150.18415699
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.17587438
85Hepatitis B_Homo sapiens_hsa051610.17295778
86Pancreatic cancer_Homo sapiens_hsa052120.15567913
87Fatty acid biosynthesis_Homo sapiens_hsa000610.15183717
88Melanoma_Homo sapiens_hsa052180.14954597
89Arginine biosynthesis_Homo sapiens_hsa002200.14298676
90Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.13324036
91Steroid biosynthesis_Homo sapiens_hsa001000.13106215
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.13007902
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.11964760
94FoxO signaling pathway_Homo sapiens_hsa040680.11551925
95Morphine addiction_Homo sapiens_hsa050320.11524419
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.10964050
97Toll-like receptor signaling pathway_Homo sapiens_hsa046200.10207635
98cAMP signaling pathway_Homo sapiens_hsa040240.09599615
99Metabolic pathways_Homo sapiens_hsa011000.09421875
100Prostate cancer_Homo sapiens_hsa052150.08941015

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