C11ORF70

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.94207383
2motile cilium assembly (GO:0044458)8.17953087
3axoneme assembly (GO:0035082)6.77580830
4intraciliary transport (GO:0042073)6.11944639
5left/right pattern formation (GO:0060972)5.77006246
6regulation of cilium movement (GO:0003352)5.70450580
7cilium organization (GO:0044782)5.25857473
8cilium assembly (GO:0042384)5.14672082
9protein localization to cilium (GO:0061512)4.86016242
10ventricular system development (GO:0021591)4.78306033
11left/right axis specification (GO:0070986)4.67548700
12cilium morphogenesis (GO:0060271)4.62195463
13mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.96924222
14microtubule bundle formation (GO:0001578)3.93409268
15cellular component assembly involved in morphogenesis (GO:0010927)3.93282422
16nonmotile primary cilium assembly (GO:0035058)3.87560795
17nucleoside diphosphate phosphorylation (GO:0006165)3.84132696
18primary alcohol catabolic process (GO:0034310)3.80006692
19vitamin transmembrane transport (GO:0035461)3.60772457
20GTP biosynthetic process (GO:0006183)3.57964857
21mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.55319079
22energy coupled proton transport, down electrochemical gradient (GO:0015985)3.47837823
23ATP synthesis coupled proton transport (GO:0015986)3.47837823
24regulation of microtubule-based movement (GO:0060632)3.38285771
25centriole assembly (GO:0098534)3.34145627
26cell projection assembly (GO:0030031)3.30777128
27negative regulation of T cell differentiation in thymus (GO:0033085)3.30575770
28diterpenoid biosynthetic process (GO:0016102)3.26975406
29microtubule-based movement (GO:0007018)3.26524908
30smoothened signaling pathway (GO:0007224)3.22092339
31determination of left/right symmetry (GO:0007368)3.20966755
32terpenoid biosynthetic process (GO:0016114)3.18416769
33pyrimidine-containing compound transmembrane transport (GO:0072531)3.18181658
34glutathione derivative metabolic process (GO:1901685)3.15817274
35glutathione derivative biosynthetic process (GO:1901687)3.15817274
36protein complex biogenesis (GO:0070271)3.11537893
37centriole replication (GO:0007099)3.11135942
38determination of bilateral symmetry (GO:0009855)3.04472887
39sperm motility (GO:0030317)3.03669399
40mitochondrial respiratory chain complex assembly (GO:0033108)2.99736019
41specification of symmetry (GO:0009799)2.98195065
42ethanol metabolic process (GO:0006067)2.95867758
43electron transport chain (GO:0022900)2.91606056
44UTP biosynthetic process (GO:0006228)2.91472203
45cornea development in camera-type eye (GO:0061303)2.88381824
46aldehyde catabolic process (GO:0046185)2.87063838
47one-carbon compound transport (GO:0019755)2.86510261
48microtubule depolymerization (GO:0007019)2.84163036
49respiratory electron transport chain (GO:0022904)2.81083234
50retinoic acid metabolic process (GO:0042573)2.79281181
51purine nucleoside triphosphate biosynthetic process (GO:0009145)2.78754369
52mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.77896723
53mitochondrial respiratory chain complex I assembly (GO:0032981)2.77896723
54NADH dehydrogenase complex assembly (GO:0010257)2.77896723
55proteasome assembly (GO:0043248)2.77748612
56protein polyglutamylation (GO:0018095)2.77444688
57lateral sprouting from an epithelium (GO:0060601)2.75638971
58purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.73924299
59response to xenobiotic stimulus (GO:0009410)2.73561931
60UTP metabolic process (GO:0046051)2.71285585
61neural tube formation (GO:0001841)2.71048529
62male meiosis I (GO:0007141)2.70698076
63behavioral response to nicotine (GO:0035095)2.70310956
64establishment of protein localization to mitochondrial membrane (GO:0090151)2.67884865
65preassembly of GPI anchor in ER membrane (GO:0016254)2.64730695
66microtubule polymerization or depolymerization (GO:0031109)2.62384284
67photoreceptor cell maintenance (GO:0045494)2.59726268
68cellular ketone body metabolic process (GO:0046950)2.57934157
69retinal rod cell development (GO:0046548)2.54851573
70establishment of planar polarity (GO:0001736)2.54523526
71establishment of tissue polarity (GO:0007164)2.54523526
72retinol metabolic process (GO:0042572)2.52478632
73negative regulation of transcription regulatory region DNA binding (GO:2000678)2.49975112
74nucleoside triphosphate biosynthetic process (GO:0009142)2.48808437
75ATP biosynthetic process (GO:0006754)2.47385176
76lung epithelium development (GO:0060428)2.43862857
77C-terminal protein lipidation (GO:0006501)2.42551270
78respiratory chain complex IV assembly (GO:0008535)2.40404391
79C-terminal protein amino acid modification (GO:0018410)2.39756531
80establishment of monopolar cell polarity (GO:0061162)2.38882358
81establishment or maintenance of monopolar cell polarity (GO:0061339)2.38882358
82proton transport (GO:0015992)2.37930457
83platelet dense granule organization (GO:0060155)2.37773171
84ubiquinone biosynthetic process (GO:0006744)2.37550966
85CTP metabolic process (GO:0046036)2.35850565
86CTP biosynthetic process (GO:0006241)2.35850565
87establishment of apical/basal cell polarity (GO:0035089)2.35013569
88hydrogen transport (GO:0006818)2.33348118
89exogenous drug catabolic process (GO:0042738)2.33184562
90hydrogen ion transmembrane transport (GO:1902600)2.32295628
91protein-cofactor linkage (GO:0018065)2.32192131
92ribonucleoside triphosphate biosynthetic process (GO:0009201)2.30422440
93nucleotide phosphorylation (GO:0046939)2.28926854
94organelle assembly (GO:0070925)2.28804992
95spinal cord motor neuron differentiation (GO:0021522)2.28747234
96water-soluble vitamin biosynthetic process (GO:0042364)2.28426718
97axonemal dynein complex assembly (GO:0070286)13.2247110
98cilium movement (GO:0003341)10.5895847
99cilium or flagellum-dependent cell motility (GO:0001539)10.5689645
100epithelial cilium movement (GO:0003351)10.0717428

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.10212571
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.98355733
3VDR_22108803_ChIP-Seq_LS180_Human2.91122689
4ZNF274_21170338_ChIP-Seq_K562_Hela2.75208391
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.60325036
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.28927453
7FUS_26573619_Chip-Seq_HEK293_Human2.26758398
8GBX2_23144817_ChIP-Seq_PC3_Human2.15318257
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.14096960
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.12644706
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.09610376
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.07028529
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.05907268
14CTBP2_25329375_ChIP-Seq_LNCAP_Human2.02481748
15TAF15_26573619_Chip-Seq_HEK293_Human1.99408374
16SALL1_21062744_ChIP-ChIP_HESCs_Human1.98675320
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.95459699
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.88064043
19EWS_26573619_Chip-Seq_HEK293_Human1.83516157
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.83094018
21PIAS1_25552417_ChIP-Seq_VCAP_Human1.69245259
22EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.68466239
23P300_19829295_ChIP-Seq_ESCs_Human1.68320834
24ER_23166858_ChIP-Seq_MCF-7_Human1.56767518
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.55064078
26BCAT_22108803_ChIP-Seq_LS180_Human1.53830061
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.52023705
28BMI1_23680149_ChIP-Seq_NPCS_Mouse1.51629604
29EST1_17652178_ChIP-ChIP_JURKAT_Human1.51586896
30* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.48685375
31* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.44733561
32* FOXA1_25329375_ChIP-Seq_VCAP_Human1.44733561
33SMAD4_21799915_ChIP-Seq_A2780_Human1.39795102
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.39345472
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.38489033
36TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38162211
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34127381
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33438543
39MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32398406
40PHF8_20622853_ChIP-Seq_HELA_Human1.32197514
41IGF1R_20145208_ChIP-Seq_DFB_Human1.31818334
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.31802956
43MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30867404
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29050620
45STAT3_23295773_ChIP-Seq_U87_Human1.28075914
46AR_25329375_ChIP-Seq_VCAP_Human1.27542209
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.26475357
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.26065699
49EZH2_22144423_ChIP-Seq_EOC_Human1.25857935
50* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25843483
51ELK1_19687146_ChIP-ChIP_HELA_Human1.25692687
52AR_20517297_ChIP-Seq_VCAP_Human1.25104417
53TCF4_22108803_ChIP-Seq_LS180_Human1.24190635
54* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21848909
55CBP_20019798_ChIP-Seq_JUKART_Human1.20376047
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20376047
57ETV1_20927104_ChIP-Seq_GIST48_Human1.20301041
58TP53_22573176_ChIP-Seq_HFKS_Human1.19633721
59CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18403447
60FOXM1_26456572_ChIP-Seq_MCF-7_Human1.16934547
61NANOG_19829295_ChIP-Seq_ESCs_Human1.16881146
62SOX2_19829295_ChIP-Seq_ESCs_Human1.16881146
63TBL1_22424771_ChIP-Seq_293T_Human1.15856472
64MYC_18940864_ChIP-ChIP_HL60_Human1.15561684
65* RUNX2_22187159_ChIP-Seq_PCA_Human1.14036925
66PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.13758261
67JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.12594318
68CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.12241365
69HNFA_21074721_ChIP-Seq_CACO-2_Human1.10562912
70NFYB_21822215_ChIP-Seq_K562_Human1.10114937
71SRF_21415370_ChIP-Seq_HL-1_Mouse1.09690570
72FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08414784
73SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08386310
74RBPJ_21746931_ChIP-Seq_IB4_Human1.08084869
75NFYA_21822215_ChIP-Seq_K562_Human1.08079457
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07245331
77RNF2_27304074_Chip-Seq_NSC_Mouse1.07045653
78TCF4_23295773_ChIP-Seq_U87_Human1.05346470
79EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05023685
80NCOR_22424771_ChIP-Seq_293T_Human1.04824575
81UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02042552
82GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02041185
83LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01475142
84SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.01407943
85SMAD4_21741376_ChIP-Seq_EPCs_Human1.01323239
86TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01258579
87KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00216985
88* GATA3_21878914_ChIP-Seq_MCF-7_Human0.96457424
89CBX2_22325352_ChIP-Seq_293T-Rex_Human0.96417635
90VDR_23849224_ChIP-Seq_CD4+_Human0.96190819
91CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.96007808
92PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95655181
93TRIM28_21343339_ChIP-Seq_HEK293_Human0.95652383
94GATA6_21074721_ChIP-Seq_CACO-2_Human0.95469819
95SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.94698787
96NANOG_18555785_Chip-Seq_ESCs_Mouse0.94584707
97ERG_20517297_ChIP-Seq_VCAP_Human0.94458254
98TP53_18474530_ChIP-ChIP_U2OS_Human0.94019516
99TAL1_26923725_Chip-Seq_HPCs_Mouse0.93987840
100IRF1_19129219_ChIP-ChIP_H3396_Human0.93984165

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology4.25728726
2MP0008875_abnormal_xenobiotic_pharmacok3.88667151
3MP0004133_heterotaxia2.84858822
4MP0000566_synostosis2.43233164
5MP0001984_abnormal_olfaction2.41501522
6MP0004043_abnormal_pH_regulation2.41341817
7MP0003878_abnormal_ear_physiology2.22429544
8MP0005377_hearing/vestibular/ear_phenot2.22429544
9MP0008789_abnormal_olfactory_epithelium2.12703228
10MP0002282_abnormal_trachea_morphology2.03735982
11MP0010030_abnormal_orbit_morphology1.98859994
12MP0003136_yellow_coat_color1.85233330
13MP0001485_abnormal_pinna_reflex1.80728736
14MP0002277_abnormal_respiratory_mucosa1.80629148
15MP0002638_abnormal_pupillary_reflex1.79021689
16MP0004019_abnormal_vitamin_homeostasis1.76190251
17MP0003880_abnormal_central_pattern1.73394415
18MP0005551_abnormal_eye_electrophysiolog1.73258912
19MP0000427_abnormal_hair_cycle1.73101711
20MP0003011_delayed_dark_adaptation1.69951529
21MP0005646_abnormal_pituitary_gland1.68596813
22MP0002160_abnormal_reproductive_system1.68552256
23MP0006072_abnormal_retinal_apoptosis1.64812333
24MP0000383_abnormal_hair_follicle1.64125899
25MP0005253_abnormal_eye_physiology1.62166513
26MP0001968_abnormal_touch/_nociception1.61005295
27MP0009046_muscle_twitch1.60602573
28MP0009780_abnormal_chondrocyte_physiolo1.59710442
29MP0005623_abnormal_meninges_morphology1.56828417
30MP0002102_abnormal_ear_morphology1.56730396
31MP0003195_calcinosis1.54647155
32MP0002876_abnormal_thyroid_physiology1.50113722
33MP0002736_abnormal_nociception_after1.50100055
34MP0003806_abnormal_nucleotide_metabolis1.49494923
35MP0001293_anophthalmia1.46652393
36MP0002735_abnormal_chemical_nociception1.45810871
37MP0001346_abnormal_lacrimal_gland1.45313172
38MP0000631_abnormal_neuroendocrine_gland1.43741690
39MP0003718_maternal_effect1.34666574
40MP0000647_abnormal_sebaceous_gland1.34616690
41MP0002938_white_spotting1.33121029
42MP0002837_dystrophic_cardiac_calcinosis1.31677646
43MP0003937_abnormal_limbs/digits/tail_de1.30917629
44MP0002909_abnormal_adrenal_gland1.30422339
45MP0004885_abnormal_endolymph1.29250771
46MP0000026_abnormal_inner_ear1.26967874
47MP0009745_abnormal_behavioral_response1.26335904
48MP0005394_taste/olfaction_phenotype1.24950548
49MP0005499_abnormal_olfactory_system1.24950548
50MP0006292_abnormal_olfactory_placode1.20227352
51MP0002234_abnormal_pharynx_morphology1.20137450
52MP0008877_abnormal_DNA_methylation1.19095733
53MP0001905_abnormal_dopamine_level1.18849001
54MP0002132_abnormal_respiratory_system1.18781581
55MP0000049_abnormal_middle_ear1.17261928
56MP0003938_abnormal_ear_development1.15803595
57MP0010386_abnormal_urinary_bladder1.15759334
58MP0005389_reproductive_system_phenotype1.14327870
59MP0002734_abnormal_mechanical_nocicepti1.13149371
60MP0002928_abnormal_bile_duct1.12849916
61MP0004142_abnormal_muscle_tone1.12386455
62MP0001529_abnormal_vocalization1.09155978
63MP0002233_abnormal_nose_morphology1.07895946
64MP0010678_abnormal_skin_adnexa1.07288313
65MP0001986_abnormal_taste_sensitivity1.05468481
66MP0001929_abnormal_gametogenesis1.05222977
67MP0008872_abnormal_physiological_respon1.03737446
68MP0003186_abnormal_redox_activity1.02456462
69MP0008058_abnormal_DNA_repair1.01899641
70MP0003698_abnormal_male_reproductive1.01215183
71MP0001970_abnormal_pain_threshold0.99306072
72MP0005084_abnormal_gallbladder_morpholo0.98894405
73MP0005391_vision/eye_phenotype0.98616974
74MP0005195_abnormal_posterior_eye0.97664687
75MP0009697_abnormal_copulation0.96938456
76MP0003119_abnormal_digestive_system0.96639273
77MP0002272_abnormal_nervous_system0.95792812
78MP0002557_abnormal_social/conspecific_i0.95663748
79MP0005645_abnormal_hypothalamus_physiol0.95593822
80MP0002210_abnormal_sex_determination0.94577846
81MP0001324_abnormal_eye_pigmentation0.93384815
82MP0002572_abnormal_emotion/affect_behav0.93293639
83MP0000778_abnormal_nervous_system0.92831932
84MP0001764_abnormal_homeostasis0.91322475
85MP0001486_abnormal_startle_reflex0.90814378
86MP0005395_other_phenotype0.88369120
87MP0003890_abnormal_embryonic-extraembry0.87025536
88MP0000653_abnormal_sex_gland0.84035400
89MP0003122_maternal_imprinting0.83640647
90MP0001145_abnormal_male_reproductive0.82914762
91MP0002752_abnormal_somatic_nervous0.81265709
92MP0001963_abnormal_hearing_physiology0.80808308
93MP0003252_abnormal_bile_duct0.79809556
94MP0000372_irregular_coat_pigmentation0.78623266
95MP0002733_abnormal_thermal_nociception0.78608160
96MP0005085_abnormal_gallbladder_physiolo0.78464733
97MP0001286_abnormal_eye_development0.78436759
98MP0005636_abnormal_mineral_homeostasis0.75569964
99MP0000569_abnormal_digit_pigmentation0.75215830
100MP0005248_abnormal_Harderian_gland0.74284602

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.90428965
2Abnormal respiratory motile cilium physiology (HP:0012261)8.59406260
3Abnormal respiratory motile cilium morphology (HP:0005938)8.38033267
4Abnormal respiratory epithelium morphology (HP:0012253)8.38033267
5Abnormal ciliary motility (HP:0012262)8.37413790
6Dynein arm defect of respiratory motile cilia (HP:0012255)8.14475687
7Absent/shortened dynein arms (HP:0200106)8.14475687
8Rhinitis (HP:0012384)7.66756960
9Chronic bronchitis (HP:0004469)6.16333072
10Bronchiectasis (HP:0002110)5.22973567
11Pancreatic fibrosis (HP:0100732)4.80498627
12True hermaphroditism (HP:0010459)4.69741768
13Pancreatic cysts (HP:0001737)4.31148612
14Nasal polyposis (HP:0100582)4.14899684
15Molar tooth sign on MRI (HP:0002419)4.14694660
16Abnormality of midbrain morphology (HP:0002418)4.14694660
17Nephronophthisis (HP:0000090)4.08702347
18Occipital encephalocele (HP:0002085)3.95261389
19Cystic liver disease (HP:0006706)3.38989873
20Medial flaring of the eyebrow (HP:0010747)3.36171986
21Abnormality of the renal medulla (HP:0100957)3.31359685
22Chronic hepatic failure (HP:0100626)3.28956618
23Abnormality of the nasal mucosa (HP:0000433)3.23909120
24Postaxial foot polydactyly (HP:0001830)2.95645118
25Chronic sinusitis (HP:0011109)2.91152912
26Gait imbalance (HP:0002141)2.90288628
27Anencephaly (HP:0002323)2.90199507
28Bronchitis (HP:0012387)2.90159073
29Congenital primary aphakia (HP:0007707)2.87829392
30Recurrent sinusitis (HP:0011108)2.86118273
31Sclerocornea (HP:0000647)2.79732840
32Aplasia/Hypoplasia of the tongue (HP:0010295)2.77992203
33Tubular atrophy (HP:0000092)2.77523326
34Infertility (HP:0000789)2.70128699
35Congenital hepatic fibrosis (HP:0002612)2.68244350
36Nephrogenic diabetes insipidus (HP:0009806)2.64610223
37Male pseudohermaphroditism (HP:0000037)2.44018995
38Furrowed tongue (HP:0000221)2.42611313
39Abnormality of the renal cortex (HP:0011035)2.34227729
40Oculomotor apraxia (HP:0000657)2.32078940
41Genital tract atresia (HP:0001827)2.27991572
42Postaxial hand polydactyly (HP:0001162)2.26675693
43Vaginal atresia (HP:0000148)2.25179256
44Recurrent otitis media (HP:0000403)2.16763248
45Polydipsia (HP:0001959)2.14331961
46Abnormal drinking behavior (HP:0030082)2.14331961
47Preaxial hand polydactyly (HP:0001177)2.12308527
48Tubulointerstitial nephritis (HP:0001970)2.09934084
49Acute necrotizing encephalopathy (HP:0006965)2.03609270
50Poor coordination (HP:0002370)1.98024244
51Abnormal biliary tract physiology (HP:0012439)1.96905778
52Bile duct proliferation (HP:0001408)1.96905778
53Hyperactive renin-angiotensin system (HP:0000841)1.94844436
54Male infertility (HP:0003251)1.91345620
55Mitochondrial inheritance (HP:0001427)1.91091797
56Chronic otitis media (HP:0000389)1.87499916
57Abnormal mitochondria in muscle tissue (HP:0008316)1.86502842
58Anophthalmia (HP:0000528)1.83712061
59Acute encephalopathy (HP:0006846)1.82075154
60Median cleft lip (HP:0000161)1.81209513
61Atelectasis (HP:0100750)1.76702652
62Abnormality of macular pigmentation (HP:0008002)1.73151213
63Progressive macrocephaly (HP:0004481)1.72188111
64Aganglionic megacolon (HP:0002251)1.69533683
65Increased CSF lactate (HP:0002490)1.61885522
66Nephropathy (HP:0000112)1.61085315
67Abnormal rod and cone electroretinograms (HP:0008323)1.60813560
68Stage 5 chronic kidney disease (HP:0003774)1.60774025
693-Methylglutaconic aciduria (HP:0003535)1.60318599
70Polyuria (HP:0000103)1.60176940
71Supernumerary spleens (HP:0009799)1.57307354
72Congenital stationary night blindness (HP:0007642)1.54998665
73Aplasia/Hypoplasia of the spleen (HP:0010451)1.54743693
74Retinitis pigmentosa (HP:0000510)1.53321672
75Prominent nasal bridge (HP:0000426)1.53158746
76Decreased circulating renin level (HP:0003351)1.52941981
77Aplasia/hypoplasia of the uterus (HP:0008684)1.50160487
78Narrow forehead (HP:0000341)1.50156776
79Aplasia/Hypoplasia of the lens (HP:0008063)1.49820702
80Renal salt wasting (HP:0000127)1.48466267
81Esophageal atresia (HP:0002032)1.47140827
82Multicystic kidney dysplasia (HP:0000003)1.44480095
83Tubulointerstitial abnormality (HP:0001969)1.43503125
84Congenital, generalized hypertrichosis (HP:0004540)1.42648982
85Increased hepatocellular lipid droplets (HP:0006565)1.41992953
86Lipid accumulation in hepatocytes (HP:0006561)1.40027483
87Holoprosencephaly (HP:0001360)1.38876534
88Bell-shaped thorax (HP:0001591)1.38796031
89Decreased central vision (HP:0007663)1.37045609
90Asplenia (HP:0001746)1.35242691
91Hepatocellular necrosis (HP:0001404)1.35133274
92Broad foot (HP:0001769)1.35010145
93Absent rod-and cone-mediated responses on ERG (HP:0007688)1.34136646
94Oligodactyly (hands) (HP:0001180)1.33694058
95Type II lissencephaly (HP:0007260)1.32948997
96Highly arched eyebrow (HP:0002553)1.32864578
97Renal dysplasia (HP:0000110)1.32555691
98Oligohydramnios (HP:0001562)1.29303731
99Pendular nystagmus (HP:0012043)1.28641634
100Facial cleft (HP:0002006)1.27847384

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK155.62700198
2PNCK3.19481324
3MST42.94390158
4NME12.83943352
5FRK2.72011925
6EPHA22.31751802
7MAP4K22.26422686
8ZAK2.20278706
9INSRR2.18327826
10WNK32.14826555
11TLK12.10321118
12STK162.07713547
13CASK1.98308342
14OXSR11.93873118
15BMPR1B1.83298878
16GRK11.82936234
17WNK41.70774282
18ADRBK21.68688044
19STK38L1.67640101
20MAP3K121.63762532
21PTK2B1.56604297
22MAPK131.40628308
23VRK21.33789543
24WEE11.33668359
25BCR1.26894497
26MAP3K41.22784160
27STK391.21196203
28VRK11.19007871
29MAPKAPK31.18866356
30TTK1.17345216
31PINK11.15652704
32MET1.14039671
33LATS11.11490904
34EPHA31.11141261
35EPHA41.08605902
36NUAK11.05453286
37CDK191.04946704
38TNIK1.02934703
39CSNK1G20.99164418
40MAP2K70.97727855
41MAPKAPK50.97051356
42STK240.93550755
43DYRK20.92894721
44BRSK20.91071484
45PAK30.90140050
46EPHB20.86669502
47PRKCE0.85689600
48ACVR1B0.85135550
49CSNK1G10.84058183
50PLK20.79317967
51MAP3K20.78446863
52DYRK30.78289298
53PBK0.77268286
54PRKCI0.76893326
55CSNK1G30.75648052
56TSSK60.75592619
57PHKG20.74627008
58PHKG10.74627008
59ERBB30.73844693
60PLK30.71523371
61ADRBK10.70632172
62PLK10.69471276
63BUB10.69395486
64BCKDK0.67807473
65MYLK0.67533004
66TRIM280.66870257
67TAF10.65051040
68MARK10.64974634
69SRPK10.64883886
70PLK40.64148736
71STK30.62344742
72MUSK0.60353986
73FGFR20.58863361
74MKNK20.58094205
75PRKCG0.57537820
76CSNK1A1L0.56955071
77NTRK30.56912038
78IRAK10.55400678
79CCNB10.52871739
80CAMK2A0.52322446
81PRKD30.50989499
82RPS6KA50.50127420
83LIMK10.49438571
84TGFBR10.49376381
85FER0.47373146
86CAMKK20.46370469
87MKNK10.45649375
88NLK0.44135685
89CHEK20.42999242
90PKN10.37761085
91STK380.34767479
92EIF2AK10.33754477
93PRKACA0.31572903
94ABL20.31148720
95CAMK2G0.30587812
96EPHB10.30430976
97NTRK20.30059883
98ERBB20.29592473
99AURKA0.25835758
100CSNK1A10.25538116

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.32350791
2Huntingtons disease_Homo sapiens_hsa050162.92739176
3Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.85985917
4Parkinsons disease_Homo sapiens_hsa050122.59944318
5Chemical carcinogenesis_Homo sapiens_hsa052042.55081234
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.42468343
7Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.40725385
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.37911758
9Proteasome_Homo sapiens_hsa030502.35661456
10Protein export_Homo sapiens_hsa030602.18074210
11Tyrosine metabolism_Homo sapiens_hsa003502.03582310
12Phenylalanine metabolism_Homo sapiens_hsa003601.87075023
13RNA polymerase_Homo sapiens_hsa030201.81862124
14Alzheimers disease_Homo sapiens_hsa050101.76315996
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.75487790
16Glutathione metabolism_Homo sapiens_hsa004801.74548899
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.70093646
18Histidine metabolism_Homo sapiens_hsa003401.68745822
19Linoleic acid metabolism_Homo sapiens_hsa005911.64147673
20Phototransduction_Homo sapiens_hsa047441.61304760
21Caffeine metabolism_Homo sapiens_hsa002321.60106662
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.55465644
23Nicotine addiction_Homo sapiens_hsa050331.51467872
24Retinol metabolism_Homo sapiens_hsa008301.49183968
25Homologous recombination_Homo sapiens_hsa034401.49179110
26Collecting duct acid secretion_Homo sapiens_hsa049661.48359670
27Peroxisome_Homo sapiens_hsa041461.45795356
28beta-Alanine metabolism_Homo sapiens_hsa004101.45067955
29Nitrogen metabolism_Homo sapiens_hsa009101.41966423
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.37924308
31Ribosome_Homo sapiens_hsa030101.37532204
32Propanoate metabolism_Homo sapiens_hsa006401.34412441
33Fanconi anemia pathway_Homo sapiens_hsa034601.32934826
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.32910149
35Cardiac muscle contraction_Homo sapiens_hsa042601.32012618
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.30610412
37Butanoate metabolism_Homo sapiens_hsa006501.29396224
38Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.29141315
39Primary bile acid biosynthesis_Homo sapiens_hsa001201.26023708
40Sulfur metabolism_Homo sapiens_hsa009201.25968439
41Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.17894380
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.10797000
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.10608467
44Basal transcription factors_Homo sapiens_hsa030221.09764749
45Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.08874778
46Nucleotide excision repair_Homo sapiens_hsa034201.08796924
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.07499725
48Maturity onset diabetes of the young_Homo sapiens_hsa049501.06582093
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.05753769
50Folate biosynthesis_Homo sapiens_hsa007901.05438000
51Tryptophan metabolism_Homo sapiens_hsa003800.99803837
52Purine metabolism_Homo sapiens_hsa002300.98470883
53Hedgehog signaling pathway_Homo sapiens_hsa043400.94648513
54Metabolic pathways_Homo sapiens_hsa011000.94471217
55Selenocompound metabolism_Homo sapiens_hsa004500.93685809
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.89496153
57Basal cell carcinoma_Homo sapiens_hsa052170.89420331
58Mismatch repair_Homo sapiens_hsa034300.87754639
59Sulfur relay system_Homo sapiens_hsa041220.83635725
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.82148883
61Pyrimidine metabolism_Homo sapiens_hsa002400.81693488
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.79208202
63Arachidonic acid metabolism_Homo sapiens_hsa005900.78885645
64Pyruvate metabolism_Homo sapiens_hsa006200.78073536
65Taste transduction_Homo sapiens_hsa047420.76961484
66One carbon pool by folate_Homo sapiens_hsa006700.75913279
67Ether lipid metabolism_Homo sapiens_hsa005650.75407645
68Steroid biosynthesis_Homo sapiens_hsa001000.74050234
69Fatty acid degradation_Homo sapiens_hsa000710.73934379
70RNA degradation_Homo sapiens_hsa030180.71275276
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69773755
72ABC transporters_Homo sapiens_hsa020100.69137379
73Fatty acid elongation_Homo sapiens_hsa000620.69054579
74Sphingolipid metabolism_Homo sapiens_hsa006000.64263724
75N-Glycan biosynthesis_Homo sapiens_hsa005100.63400930
76Circadian rhythm_Homo sapiens_hsa047100.62058164
77Vitamin digestion and absorption_Homo sapiens_hsa049770.61413261
78Regulation of autophagy_Homo sapiens_hsa041400.60385448
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59899857
80Olfactory transduction_Homo sapiens_hsa047400.58430569
81Arginine and proline metabolism_Homo sapiens_hsa003300.53508481
82Mineral absorption_Homo sapiens_hsa049780.53041427
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49444056
84Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.47321887
85Cocaine addiction_Homo sapiens_hsa050300.46667625
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45864875
87GABAergic synapse_Homo sapiens_hsa047270.43051545
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.42205190
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40932738
90Salivary secretion_Homo sapiens_hsa049700.40796039
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40717111
92Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.37829236
93Hippo signaling pathway_Homo sapiens_hsa043900.37647146
94Morphine addiction_Homo sapiens_hsa050320.37440314
95Tight junction_Homo sapiens_hsa045300.35552643
96Serotonergic synapse_Homo sapiens_hsa047260.35414892
97Glycerolipid metabolism_Homo sapiens_hsa005610.31378551
98Glutamatergic synapse_Homo sapiens_hsa047240.28871425
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.27101180
100Spliceosome_Homo sapiens_hsa030400.25672161

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