C11ORF68

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to endosome (GO:0036010)4.12030901
2negative regulation of erythrocyte differentiation (GO:0045647)3.99949845
3regulation of early endosome to late endosome transport (GO:2000641)3.87586816
4negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.70620942
5stress fiber assembly (GO:0043149)3.68602807
6barbed-end actin filament capping (GO:0051016)3.55904534
7negative regulation of cell size (GO:0045792)3.40685617
8protein retention in ER lumen (GO:0006621)3.35273605
9synaptic vesicle docking involved in exocytosis (GO:0016081)3.29659428
10skin morphogenesis (GO:0043589)3.22460182
11maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.10940571
12negative regulation of necrotic cell death (GO:0060547)3.05519894
13regulation of T-helper 2 cell differentiation (GO:0045628)3.02983513
14COPI coating of Golgi vesicle (GO:0048205)3.01073692
15Golgi transport vesicle coating (GO:0048200)3.01073692
16positive regulation of protein dephosphorylation (GO:0035307)2.98977166
17response to peptidoglycan (GO:0032494)2.95381775
18modulation by symbiont of host cellular process (GO:0044068)2.86805786
19regulation of extracellular matrix disassembly (GO:0010715)2.85033534
20positive regulation of blood vessel endothelial cell migration (GO:0043536)2.84166553
21positive regulation of fibroblast migration (GO:0010763)2.82843270
22virion attachment to host cell (GO:0019062)2.82559955
23adhesion of symbiont to host cell (GO:0044650)2.82559955
24signal complex assembly (GO:0007172)2.78923754
25cell-substrate adherens junction assembly (GO:0007045)2.77780677
26focal adhesion assembly (GO:0048041)2.77780677
27regulation of necrotic cell death (GO:0010939)2.77400039
28pinocytosis (GO:0006907)2.76263221
29adherens junction assembly (GO:0034333)2.75862928
30positive regulation of receptor recycling (GO:0001921)2.75816718
31modulation by symbiont of host defense response (GO:0052031)2.74524693
32modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.74524693
33modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.74524693
34positive regulation by organism of defense response of other organism involved in symbiotic interact2.74524693
35modulation by symbiont of host immune response (GO:0052553)2.74524693
36positive regulation by symbiont of host defense response (GO:0052509)2.74524693
37positive regulation of Cdc42 GTPase activity (GO:0043089)2.74280131
38vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.72004404
39protein targeting to plasma membrane (GO:0072661)2.69726065
40antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.65995448
41activation of Rac GTPase activity (GO:0032863)2.61480549
42negative regulation of cell killing (GO:0031342)2.60860328
43negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.60860328
44adhesion of symbiont to host (GO:0044406)2.60323659
45G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.58860422
46cell-substrate junction assembly (GO:0007044)2.58424196
47modulation by virus of host process (GO:0019054)2.57323947
48retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.57036190
49mannose metabolic process (GO:0006013)2.56947272
50positive regulation of extracellular matrix organization (GO:1903055)2.56800496
51positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.56256929
52endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.52985052
53negative regulation of necroptotic process (GO:0060546)2.52576359
54regulation of mammary gland epithelial cell proliferation (GO:0033599)2.52276163
55cytoskeletal anchoring at plasma membrane (GO:0007016)2.51509686
56regulation of macrophage cytokine production (GO:0010935)2.50615605
57adenosine receptor signaling pathway (GO:0001973)2.49705356
58cortical actin cytoskeleton organization (GO:0030866)2.48413554
59regulation of ARF protein signal transduction (GO:0032012)2.48408794
60negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.46511136
61activation of MAPKKK activity (GO:0000185)2.45737506
62negative regulation of homotypic cell-cell adhesion (GO:0034111)2.45483863
63antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.45239399
64positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.44575694
65response to laminar fluid shear stress (GO:0034616)2.44273635
66negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.43111517
67antigen processing and presentation of endogenous antigen (GO:0019883)2.41065105
68peptidyl-proline hydroxylation (GO:0019511)2.40865936
69endocytic recycling (GO:0032456)2.38262367
70hypotonic response (GO:0006971)2.37800299
71extracellular fibril organization (GO:0043206)2.36915284
72fibril organization (GO:0097435)2.34657964
73cell-cell junction maintenance (GO:0045217)2.34160110
74lipopolysaccharide-mediated signaling pathway (GO:0031663)2.33922410
75regulation of response to osmotic stress (GO:0047484)2.33666875
76glutamate secretion (GO:0014047)2.33613656
77hyaluronan catabolic process (GO:0030214)2.32342812
78negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.32180335
79positive regulation of macrophage cytokine production (GO:0060907)2.31682814
80UV protection (GO:0009650)2.30462215
81substrate-dependent cell migration (GO:0006929)2.30024048
82synaptic vesicle exocytosis (GO:0016079)2.29875953
83response to host (GO:0075136)2.29445865
84response to host defenses (GO:0052200)2.29445865
85response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.29445865
86macrophage activation involved in immune response (GO:0002281)2.29279240
87endodermal cell differentiation (GO:0035987)2.29247273
88platelet aggregation (GO:0070527)2.28776805
89regulation of apoptotic process involved in morphogenesis (GO:1902337)2.26995837
90regulation of leukocyte degranulation (GO:0043300)2.26532339
91protein maturation by protein folding (GO:0022417)2.22633335
92regulation of protein dephosphorylation (GO:0035304)2.22142978
93regulation of ARF GTPase activity (GO:0032312)2.21715067
94modulation by virus of host morphology or physiology (GO:0019048)2.21572239
95protein hydroxylation (GO:0018126)2.21269617
96cortical cytoskeleton organization (GO:0030865)2.20122096
97pentose-phosphate shunt (GO:0006098)2.18775272
98regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.18648443
99positive regulation of myotube differentiation (GO:0010831)2.17793280
100actin filament bundle organization (GO:0061572)2.17178853

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.32023642
2RARG_19884340_ChIP-ChIP_MEFs_Mouse3.27657256
3* LXR_22292898_ChIP-Seq_THP-1_Human2.96908845
4* ELK3_25401928_ChIP-Seq_HUVEC_Human2.82203016
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.55312840
6KDM2B_26808549_Chip-Seq_SUP-B15_Human2.46914561
7VDR_21846776_ChIP-Seq_THP-1_Human2.42857227
8NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.33542410
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.19836081
10KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.18676295
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.18049811
12* RACK7_27058665_Chip-Seq_MCF-7_Human2.15729343
13TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.09175779
14* KDM2B_26808549_Chip-Seq_DND41_Human2.05699509
15KDM2B_26808549_Chip-Seq_K562_Human1.89994013
16MYC_22102868_ChIP-Seq_BL_Human1.89390777
17TCF7_22412390_ChIP-Seq_EML_Mouse1.85830098
18RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.82951869
19* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.82588314
20EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76132378
21* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.73511374
22ZFP281_18757296_ChIP-ChIP_E14_Mouse1.68273131
23PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.67809611
24CTCF_27219007_Chip-Seq_ERYTHROID_Human1.65053489
25PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.61450058
26TET1_21451524_ChIP-Seq_MESCs_Mouse1.61373551
27EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.60345617
28SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.59859134
29VDR_24763502_ChIP-Seq_THP-1_Human1.59368888
30SA1_27219007_Chip-Seq_ERYTHROID_Human1.59209507
31ESR2_21235772_ChIP-Seq_MCF-7_Human1.57333772
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.56276812
33STAT6_21828071_ChIP-Seq_BEAS2B_Human1.55333909
34SRY_22984422_ChIP-ChIP_TESTIS_Rat1.54174296
35ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.53010740
36RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.52509554
37P68_20966046_ChIP-Seq_HELA_Human1.51897465
38ZNF263_19887448_ChIP-Seq_K562_Human1.45221141
39WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.44459496
40* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.43146250
41KDM2B_26808549_Chip-Seq_JURKAT_Human1.42678784
42ELF1_20517297_ChIP-Seq_JURKAT_Human1.41926856
43MAF_26560356_Chip-Seq_TH1_Human1.39312498
44TRIM28_21343339_ChIP-Seq_HEK293_Human1.38429892
45SMC4_20622854_ChIP-Seq_HELA_Human1.37952583
46RUNX1_22412390_ChIP-Seq_EML_Mouse1.36882261
47* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.36639313
48MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.35554103
49EGR1_19374776_ChIP-ChIP_THP-1_Human1.34785968
50DNAJC2_21179169_ChIP-ChIP_NT2_Human1.33294404
51SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.33211280
52KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.32647887
53KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.31313171
54TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29873397
55KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.29548773
56E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.28229609
57PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28194871
58TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.28193093
59* TP53_22127205_ChIP-Seq_IMR90_Human1.27963932
60MAF_26560356_Chip-Seq_TH2_Human1.27296562
61* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.26899964
62CLOCK_20551151_ChIP-Seq_293T_Human1.26721686
63TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25727617
64NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.25313559
65* ATF3_27146783_Chip-Seq_COLON_Human1.24092821
66SMC1_22415368_ChIP-Seq_MEFs_Mouse1.23179972
67BRD4_27068464_Chip-Seq_AML-cells_Mouse1.22779033
68EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.21577439
69RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.20130401
70NCOR1_26117541_ChIP-Seq_K562_Human1.19681395
71MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.19397642
72BCL6_27268052_Chip-Seq_Bcells_Human1.19264016
73UTX_26944678_Chip-Seq_JUKART_Human1.18302853
74BCOR_27268052_Chip-Seq_Bcells_Human1.17826192
75NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.17803640
76CREB1_26743006_Chip-Seq_LNCaP_Human1.15922690
77SPI1_23127762_ChIP-Seq_K562_Human1.15545957
78MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.14616398
79CTCF_27219007_Chip-Seq_Bcells_Human1.13733311
80CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.13606002
81CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.12665729
82GATA1_22383799_ChIP-Seq_G1ME_Mouse1.12306163
83TET1_21490601_ChIP-Seq_MESCs_Mouse1.11703652
84GATA1_19941826_ChIP-Seq_K562_Human1.11219441
85GATA1_19941827_ChIP-Seq_MEL_Mouse1.10163400
86IKZF1_21737484_ChIP-ChIP_HCT116_Human1.08207301
87MYB_21317192_ChIP-Seq_ERMYB_Mouse1.07907688
88SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.07450676
89CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.06587183
90CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.06478350
91CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05150619
92SMC3_22415368_ChIP-Seq_MEFs_Mouse1.05112271
93SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.04887169
94TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04018861
95ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.02789543
96PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00449743
97ZFP281_27345836_Chip-Seq_ESCs_Mouse0.98298012
98PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98147981
99SA1_27219007_Chip-Seq_Bcells_Human0.96254025
100UBF1/2_26484160_Chip-Seq_HMECs_Human0.95951955

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.27953911
2MP0003705_abnormal_hypodermis_morpholog4.27537799
3MP0005058_abnormal_lysosome_morphology3.19259784
4MP0003191_abnormal_cellular_cholesterol3.02973727
5MP0009840_abnormal_foam_cell2.74342768
6MP0005451_abnormal_body_composition2.71528242
7MP0004510_myositis2.65196718
8MP0003436_decreased_susceptibility_to2.56176575
9MP0003279_aneurysm2.51952400
10MP0003303_peritoneal_inflammation2.42742642
11MP0009278_abnormal_bone_marrow2.41952887
12MP0003566_abnormal_cell_adhesion2.34761778
13MP0001958_emphysema2.25072767
14MP0004859_abnormal_synaptic_plasticity2.24787386
15MP0004858_abnormal_nervous_system2.20869911
16MP0000751_myopathy2.17209234
17MP0008260_abnormal_autophagy2.07213172
18MP0003172_abnormal_lysosome_physiology2.04049209
19MP0003329_amyloid_beta_deposits1.85264683
20MP0005623_abnormal_meninges_morphology1.84615290
21MP0003300_gastrointestinal_ulcer1.83953722
22MP0005464_abnormal_platelet_physiology1.79127243
23MP0003075_altered_response_to1.76841334
24MP0003091_abnormal_cell_migration1.71847313
25MP0001849_ear_inflammation1.69107088
26MP0005023_abnormal_wound_healing1.66308755
27MP0001533_abnormal_skeleton_physiology1.59688999
28MP0005257_abnormal_intraocular_pressure1.56367517
29MP0004272_abnormal_basement_membrane1.56059732
30MP0000858_altered_metastatic_potential1.55543944
31MP0000343_altered_response_to1.49485710
32MP0001542_abnormal_bone_strength1.46709602
33MP0002877_abnormal_melanocyte_morpholog1.39605008
34MP0005397_hematopoietic_system_phenotyp1.37975162
35MP0001545_abnormal_hematopoietic_system1.37975162
36MP0004947_skin_inflammation1.36970871
37MP0002419_abnormal_innate_immunity1.33565693
38MP0000604_amyloidosis1.33021331
39MP0003879_abnormal_hair_cell1.31800226
40MP0000759_abnormal_skeletal_muscle1.27522764
41MP0002998_abnormal_bone_remodeling1.25503550
42MP0001348_abnormal_lacrimal_gland1.24739049
43MP0006082_CNS_inflammation1.23147848
44MP0005503_abnormal_tendon_morphology1.21999410
45MP0005390_skeleton_phenotype1.20775530
46MP0000749_muscle_degeneration1.20413564
47MP0003828_pulmonary_edema1.20019797
48MP0005275_abnormal_skin_tensile1.16423107
49MP0003724_increased_susceptibility_to1.15320730
50MP0005025_abnormal_response_to1.14045948
51MP0000767_abnormal_smooth_muscle1.12054256
52MP0000750_abnormal_muscle_regeneration1.11672858
53MP0003453_abnormal_keratinocyte_physiol1.09404557
54MP0000920_abnormal_myelination1.06508195
55MP0005000_abnormal_immune_tolerance1.05681296
56MP0008874_decreased_physiological_sensi1.05555292
57MP0005076_abnormal_cell_differentiation1.05319758
58MP0000747_muscle_weakness1.03082669
59MP0010368_abnormal_lymphatic_system1.02322427
60MP0005166_decreased_susceptibility_to1.01713148
61MP0003634_abnormal_glial_cell1.01280501
62MP0008004_abnormal_stomach_pH0.99529510
63MP0002060_abnormal_skin_morphology0.99300139
64MP0004185_abnormal_adipocyte_glucose0.98916642
65MP0005375_adipose_tissue_phenotype0.98752029
66MP0005164_abnormal_response_to0.97849047
67MP0000685_abnormal_immune_system0.97829353
68MP0005666_abnormal_adipose_tissue0.97139376
69MP0003448_altered_tumor_morphology0.96548105
70MP0000003_abnormal_adipose_tissue0.96279640
71MP0000733_abnormal_muscle_development0.94521410
72MP0004233_abnormal_muscle_weight0.94127103
73MP0002295_abnormal_pulmonary_circulatio0.93723090
74MP0002089_abnormal_postnatal_growth/wei0.93280117
75MP0002148_abnormal_hypersensitivity_rea0.92759330
76MP0005165_increased_susceptibility_to0.92019369
77MP0009384_cardiac_valve_regurgitation0.91240522
78MP0000678_abnormal_parathyroid_gland0.90414312
79MP0005595_abnormal_vascular_smooth0.87124576
80MP0005508_abnormal_skeleton_morphology0.86667602
81MP0003690_abnormal_glial_cell0.85193281
82MP0002332_abnormal_exercise_endurance0.83963636
83MP0004087_abnormal_muscle_fiber0.82134275
84MP0002933_joint_inflammation0.81521197
85MP0002896_abnormal_bone_mineralization0.80650061
86MP0005387_immune_system_phenotype0.80462246
87MP0001790_abnormal_immune_system0.80462246
88MP0001851_eye_inflammation0.78926102
89MP0008569_lethality_at_weaning0.78000124
90MP0003795_abnormal_bone_structure0.75869208
91MP0000681_abnormal_thyroid_gland0.75376152
92MP0009333_abnormal_splenocyte_physiolog0.74737682
93MP0009785_altered_susceptibility_to0.74476343
94MP0005621_abnormal_cell_physiology0.73609773
95MP0005670_abnormal_white_adipose0.73154247
96MP0002723_abnormal_immune_serum0.65488906
97MP0002420_abnormal_adaptive_immunity0.64218590
98MP0001819_abnormal_immune_cell0.63774869
99MP0005409_darkened_coat_color0.63589216
100MP0005330_cardiomyopathy0.63440299

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.70890982
2Premature rupture of membranes (HP:0001788)4.37928510
3Vertebral compression fractures (HP:0002953)3.76205523
4Increased variability in muscle fiber diameter (HP:0003557)3.11683611
5Type 1 muscle fiber predominance (HP:0003803)3.03701215
6Increased connective tissue (HP:0009025)3.01199002
7Upper limb amyotrophy (HP:0009129)2.95837937
8Distal upper limb amyotrophy (HP:0007149)2.95837937
9Fragile skin (HP:0001030)2.95366583
10Abnormality of skeletal muscle fiber size (HP:0012084)2.93831502
11Distal lower limb muscle weakness (HP:0009053)2.90185402
12Spinal rigidity (HP:0003306)2.83939826
13Distal lower limb amyotrophy (HP:0008944)2.81113672
14Achilles tendon contracture (HP:0001771)2.77336133
15Supranuclear gaze palsy (HP:0000605)2.66227908
16Cervical subluxation (HP:0003308)2.64624540
17Obstructive sleep apnea (HP:0002870)2.63834471
18Cerebral aneurysm (HP:0004944)2.59496395
19Slender build (HP:0001533)2.59317938
20Dysostosis multiplex (HP:0000943)2.56690582
21Hyperacusis (HP:0010780)2.55391930
22Vascular tortuosity (HP:0004948)2.52919568
23Ankle contracture (HP:0006466)2.52711781
24Abnormality of glycolipid metabolism (HP:0010969)2.47332012
25Abnormality of liposaccharide metabolism (HP:0010968)2.47332012
26Abnormality of glycosphingolipid metabolism (HP:0004343)2.47332012
27Abnormality of the Achilles tendon (HP:0005109)2.44227122
28Centrally nucleated skeletal muscle fibers (HP:0003687)2.42806181
29Neurofibrillary tangles (HP:0002185)2.41633693
30Nuclear cataract (HP:0100018)2.41374373
31Difficulty climbing stairs (HP:0003551)2.36631015
32Arterial tortuosity (HP:0005116)2.35747462
33Axonal loss (HP:0003447)2.35579905
34Aortic aneurysm (HP:0004942)2.32587598
35Atrophic scars (HP:0001075)2.32533766
36Mildly elevated creatine phosphokinase (HP:0008180)2.30465428
37Blue sclerae (HP:0000592)2.28424289
38Hand muscle atrophy (HP:0009130)2.26411424
39Spondylolisthesis (HP:0003302)2.23663087
40Mitral regurgitation (HP:0001653)2.22932366
41Dilatation of the ascending aorta (HP:0005111)2.22169904
42Bladder diverticulum (HP:0000015)2.20587302
43Myopathic facies (HP:0002058)2.19129731
44Lower limb amyotrophy (HP:0007210)2.18741543
45Exercise-induced myalgia (HP:0003738)2.18013782
46Shallow orbits (HP:0000586)2.17007767
47Cerebral inclusion bodies (HP:0100314)2.16578996
48Genu recurvatum (HP:0002816)2.16561385
49Insomnia (HP:0100785)2.15889716
50Wormian bones (HP:0002645)2.15462864
51Asymmetric septal hypertrophy (HP:0001670)2.12104861
52Aortic dissection (HP:0002647)2.11015145
53Peritonitis (HP:0002586)2.10965909
54Broad face (HP:0000283)2.10473845
55Short nail (HP:0001799)2.09092600
56Cellulitis (HP:0100658)2.09010630
57Generalized amyotrophy (HP:0003700)2.08518464
58Abnormality of macrophages (HP:0004311)2.06378804
59Biconcave vertebral bodies (HP:0004586)2.05847655
60Stridor (HP:0010307)1.99511050
61Joint stiffness (HP:0001387)1.99074050
62Neuronal loss in central nervous system (HP:0002529)1.98989041
63Abnormality of dentin (HP:0010299)1.97834603
64Broad metatarsal (HP:0001783)1.97299768
65Purpura (HP:0000979)1.95569395
66Abnormality of polysaccharide metabolism (HP:0011012)1.94480915
67Abnormality of glycosaminoglycan metabolism (HP:0004371)1.94480915
68Abnormality of mucopolysaccharide metabolism (HP:0011020)1.94480915
69Disproportionate tall stature (HP:0001519)1.92577939
70Aneurysm (HP:0002617)1.92330335
71Loss of speech (HP:0002371)1.91412615
72Mucopolysacchariduria (HP:0008155)1.90027041
73Urinary glycosaminoglycan excretion (HP:0003541)1.90027041
74Hypertensive crisis (HP:0100735)1.89858202
75Round ear (HP:0100830)1.89778003
76Polygenic inheritance (HP:0010982)1.86682646
77Hypoventilation (HP:0002791)1.83960070
78Polycythemia (HP:0001901)1.83319919
79Emphysema (HP:0002097)1.82622326
80Bulbar palsy (HP:0001283)1.80507236
81Hyperparathyroidism (HP:0000843)1.77185414
82Segmental peripheral demyelination/remyelination (HP:0003481)1.76716173
83Eczematoid dermatitis (HP:0000976)1.76698544
84Muscle fiber splitting (HP:0003555)1.76443081
85Foot dorsiflexor weakness (HP:0009027)1.76244034
86Hyperextensible skin (HP:0000974)1.74950426
87Elbow flexion contracture (HP:0002987)1.74376643
88Petechiae (HP:0000967)1.73078936
89Amyloidosis (HP:0011034)1.72813946
90Ulnar bowing (HP:0003031)1.72035665
91Joint laxity (HP:0001388)1.71561124
92Coxa vara (HP:0002812)1.64978715
93Interstitial pulmonary disease (HP:0006530)1.62042127
94Soft skin (HP:0000977)1.61778663
95Easy fatigability (HP:0003388)1.61671833
96Neonatal short-limb short stature (HP:0008921)1.61070973
97Abnormality of the nasal mucosa (HP:0000433)1.60486423
98Upper motor neuron abnormality (HP:0002127)1.60078361
99Hyporeflexia of lower limbs (HP:0002600)1.59123488
100Abnormal gallbladder physiology (HP:0012438)1.58040844

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.43233735
2MAP3K113.36789953
3TRIB33.17906637
4PRPF4B2.80647228
5IRAK32.52081606
6MAP2K32.42815516
7SIK12.30222352
8ICK2.07122530
9TAOK22.06310967
10TESK12.05276688
11SMG11.94412121
12NME21.90717030
13RIPK11.89942436
14TTN1.88226536
15EPHA21.78965298
16ARAF1.78791587
17PRKD21.78013464
18EPHB11.70347020
19PAK41.66361273
20MAP3K131.62966283
21RIPK41.60448595
22TAOK11.60074217
23MAP3K31.58004671
24MAP4K11.57948216
25PRKD31.51692474
26MAP3K11.50255116
27MOS1.44338892
28MARK21.32885843
29PIM21.32297622
30PTK21.32227422
31TESK21.26475376
32PDGFRA1.26332824
33PAK61.25740825
34TBK11.23256978
35STK381.16521809
36KSR21.15900577
37NTRK11.13062406
38DDR21.07286889
39LIMK11.03626921
40IRAK41.02280733
41DYRK1B1.00668530
42MST1R0.96407629
43BRAF0.95912820
44BMX0.93363561
45PDPK10.92777035
46CDC42BPA0.91703474
47TGFBR20.91511223
48LATS20.90446266
49TNK20.89223801
50PRKG20.88973082
51LMTK20.88729354
52SIK20.86837423
53PTK60.85196574
54TYK20.81310837
55SIK30.80867652
56MYLK0.78347276
57MAPK120.78033858
58ABL20.76892901
59ZAP700.76874043
60IRAK20.75954159
61DAPK30.72028897
62PKN20.68932157
63RPS6KA20.68833939
64JAK30.68764857
65EPHB20.66419133
66MAP3K90.65938812
67HIPK20.65764537
68SCYL20.63423024
69MAP3K80.61314708
70CSK0.57974504
71PAK20.57667331
72MTOR0.57104862
73PDK10.55044990
74MAP3K70.54401003
75DMPK0.52796784
76LRRK20.52647751
77ROCK20.52381900
78PAK10.51835272
79ILK0.51095406
80PTK2B0.50864742
81DAPK10.49933635
82PHKG20.49656120
83PHKG10.49656120
84FGFR40.48948480
85GRK50.48846170
86DAPK20.48732921
87RPS6KC10.47543432
88RPS6KL10.47543432
89PRKCH0.47057220
90FES0.46650373
91MAPK70.46432444
92CDK120.44946977
93MAP3K60.44398283
94RAF10.41300570
95CAMK2G0.39056623
96CAMKK10.39003477
97MAP3K140.38559807
98CDK11A0.37755455
99MAP3K120.37226842
100GRK60.37016070

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.62930178
2Other glycan degradation_Homo sapiens_hsa005112.56973579
3Glycosaminoglycan degradation_Homo sapiens_hsa005311.80834942
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.76297679
5Osteoclast differentiation_Homo sapiens_hsa043801.71758577
6Synaptic vesicle cycle_Homo sapiens_hsa047211.65891893
7Acute myeloid leukemia_Homo sapiens_hsa052211.62177038
8Chronic myeloid leukemia_Homo sapiens_hsa052201.58016488
9VEGF signaling pathway_Homo sapiens_hsa043701.56646475
10Prion diseases_Homo sapiens_hsa050201.56576379
11Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.48731186
12Bladder cancer_Homo sapiens_hsa052191.48132888
13Toll-like receptor signaling pathway_Homo sapiens_hsa046201.44414995
14Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.42063371
15Pentose phosphate pathway_Homo sapiens_hsa000301.41049346
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.39845969
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.38616207
18Malaria_Homo sapiens_hsa051441.37266894
19Non-small cell lung cancer_Homo sapiens_hsa052231.36031288
20Amoebiasis_Homo sapiens_hsa051461.34822382
21Focal adhesion_Homo sapiens_hsa045101.33750065
22AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.32756842
23Lysosome_Homo sapiens_hsa041421.30746874
24Endocytosis_Homo sapiens_hsa041441.29079795
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.27145536
26Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.22898452
27Pancreatic cancer_Homo sapiens_hsa052121.20597845
28Leishmaniasis_Homo sapiens_hsa051401.19419812
29Neurotrophin signaling pathway_Homo sapiens_hsa047221.19401452
30Central carbon metabolism in cancer_Homo sapiens_hsa052301.17421795
31Long-term potentiation_Homo sapiens_hsa047201.16668357
32Shigellosis_Homo sapiens_hsa051311.14957258
33Salmonella infection_Homo sapiens_hsa051321.14456069
34Glioma_Homo sapiens_hsa052141.13620940
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12675477
36Phospholipase D signaling pathway_Homo sapiens_hsa040721.12518514
37Notch signaling pathway_Homo sapiens_hsa043301.11423938
38B cell receptor signaling pathway_Homo sapiens_hsa046621.09873498
39GnRH signaling pathway_Homo sapiens_hsa049121.09024119
40Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.06789825
41Vibrio cholerae infection_Homo sapiens_hsa051101.03945594
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.03078196
43TNF signaling pathway_Homo sapiens_hsa046681.02086637
44ECM-receptor interaction_Homo sapiens_hsa045121.01174369
45Tuberculosis_Homo sapiens_hsa051521.01049483
46Galactose metabolism_Homo sapiens_hsa000521.00493143
47Renal cell carcinoma_Homo sapiens_hsa052111.00032636
48ErbB signaling pathway_Homo sapiens_hsa040120.99881020
49Proteoglycans in cancer_Homo sapiens_hsa052050.99063840
50Fructose and mannose metabolism_Homo sapiens_hsa000510.99037485
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93653375
52Toxoplasmosis_Homo sapiens_hsa051450.92600249
53Sphingolipid signaling pathway_Homo sapiens_hsa040710.91596019
54Platelet activation_Homo sapiens_hsa046110.91524145
55Insulin signaling pathway_Homo sapiens_hsa049100.90517661
56Regulation of actin cytoskeleton_Homo sapiens_hsa048100.90501876
57Dilated cardiomyopathy_Homo sapiens_hsa054140.90465796
58Endometrial cancer_Homo sapiens_hsa052130.89436763
59Pertussis_Homo sapiens_hsa051330.88951806
60SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87457987
61Phagosome_Homo sapiens_hsa041450.86317613
62Estrogen signaling pathway_Homo sapiens_hsa049150.81416719
63African trypanosomiasis_Homo sapiens_hsa051430.80131253
64Hepatitis B_Homo sapiens_hsa051610.79197867
65Hepatitis C_Homo sapiens_hsa051600.78476188
66Apoptosis_Homo sapiens_hsa042100.78315559
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76958879
68Rap1 signaling pathway_Homo sapiens_hsa040150.76879120
69Chemokine signaling pathway_Homo sapiens_hsa040620.76354084
70RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.74023212
71mTOR signaling pathway_Homo sapiens_hsa041500.73084544
72Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72232897
73MAPK signaling pathway_Homo sapiens_hsa040100.72159177
74Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71494150
75Influenza A_Homo sapiens_hsa051640.70888962
76Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.68495300
77Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66876031
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66723963
79Small cell lung cancer_Homo sapiens_hsa052220.66680196
80Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.64662861
81HIF-1 signaling pathway_Homo sapiens_hsa040660.64186788
82Gap junction_Homo sapiens_hsa045400.63645148
83Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.63145168
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62123332
85Inositol phosphate metabolism_Homo sapiens_hsa005620.61954803
86Viral myocarditis_Homo sapiens_hsa054160.61663014
87Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61408346
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.61248336
89Thyroid cancer_Homo sapiens_hsa052160.60536507
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59253832
91HTLV-I infection_Homo sapiens_hsa051660.59102248
92Gastric acid secretion_Homo sapiens_hsa049710.59050606
93Prolactin signaling pathway_Homo sapiens_hsa049170.57441118
94AMPK signaling pathway_Homo sapiens_hsa041520.55894220
95Melanogenesis_Homo sapiens_hsa049160.54075382
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52773596
97Oxytocin signaling pathway_Homo sapiens_hsa049210.50039798
98Measles_Homo sapiens_hsa051620.49504400
99Cocaine addiction_Homo sapiens_hsa050300.47956019
100Insulin resistance_Homo sapiens_hsa049310.46642482

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