C11ORF53

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sensory perception of taste (GO:0050909)8.43225708
2regulation of female receptivity (GO:0045924)8.31488893
3phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)8.19141975
4female mating behavior (GO:0060180)7.07544976
5adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)6.88842785
6long term synaptic depression (GO:0060292)6.46445940
7synaptic transmission, dopaminergic (GO:0001963)5.54868367
8negative regulation by host of viral transcription (GO:0043922)5.27659076
9dendritic spine morphogenesis (GO:0060997)5.07570270
10negative regulation of execution phase of apoptosis (GO:1900118)5.00866701
11aminoglycoside antibiotic metabolic process (GO:0030647)4.77403789
12transmission of nerve impulse (GO:0019226)4.56966709
13inositol phosphate dephosphorylation (GO:0046855)4.16482621
14phosphorylated carbohydrate dephosphorylation (GO:0046838)4.16482621
15regulation of ARF protein signal transduction (GO:0032012)4.00297782
16multicellular organismal reproductive behavior (GO:0033057)3.96122958
17glycoside metabolic process (GO:0016137)3.91337479
18regulation of systemic arterial blood pressure by hormone (GO:0001990)3.84653235
19regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.84653235
20endocrine process (GO:0050886)3.84653235
21auditory receptor cell differentiation (GO:0042491)3.76405829
22daunorubicin metabolic process (GO:0044597)3.75140637
23polyketide metabolic process (GO:0030638)3.75140637
24doxorubicin metabolic process (GO:0044598)3.75140637
25piRNA metabolic process (GO:0034587)3.73795471
26DNA methylation involved in gamete generation (GO:0043046)3.72702047
27dendritic spine organization (GO:0097061)3.69757100
28response to catecholamine (GO:0071869)3.68113344
29response to monoamine (GO:0071867)3.68113344
30sensory perception of chemical stimulus (GO:0007606)3.67886432
31myelin maintenance (GO:0043217)3.66615796
32inositol phosphate catabolic process (GO:0071545)3.63427453
33cellular response to monoamine stimulus (GO:0071868)3.56583061
34cellular response to catecholamine stimulus (GO:0071870)3.56583061
35phospholipid dephosphorylation (GO:0046839)3.55174992
36membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.52712471
37histone H2A acetylation (GO:0043968)3.50256021
38retinol metabolic process (GO:0042572)3.46537259
39CDP-diacylglycerol biosynthetic process (GO:0016024)3.45832230
40positive regulation of histone H3-K4 methylation (GO:0051571)3.45510507
41vesicle targeting (GO:0006903)3.43213935
42cAMP catabolic process (GO:0006198)3.42475546
43modulation by host of viral transcription (GO:0043921)3.40405525
44modulation by host of symbiont transcription (GO:0052472)3.40405525
45phosphatidylinositol dephosphorylation (GO:0046856)3.39650081
46actin filament capping (GO:0051693)3.32351585
47regulation of hydrogen peroxide metabolic process (GO:0010310)3.32109895
48modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)3.26983113
49regulation of systemic arterial blood pressure (GO:0003073)3.25567494
50negative regulation of cAMP-mediated signaling (GO:0043951)3.23457965
51positive regulation of calcium ion import (GO:0090280)3.23044636
52positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.22418867
53positive regulation of gluconeogenesis (GO:0045722)3.21875152
54negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.21499004
55response to amphetamine (GO:0001975)3.19952140
56neuron fate specification (GO:0048665)3.19797895
57cyclic nucleotide catabolic process (GO:0009214)3.19244066
58polyol catabolic process (GO:0046174)3.16976275
59termination of G-protein coupled receptor signaling pathway (GO:0038032)3.14724028
60membrane repolarization during action potential (GO:0086011)3.13037625
61protein localization to cilium (GO:0061512)3.12273418
62termination of signal transduction (GO:0023021)3.07309688
63positive regulation of mitotic sister chromatid separation (GO:1901970)3.03581580
64positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.03581580
65positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.03581580
66phosphate ion transport (GO:0006817)2.95821794
67nephron epithelium morphogenesis (GO:0072088)2.94114725
68nephron tubule morphogenesis (GO:0072078)2.94114725
69nephron tubule formation (GO:0072079)2.93922893
70positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.92961934
71neuronal action potential (GO:0019228)2.92703738
72L-alpha-amino acid transmembrane transport (GO:1902475)2.92483186
73multicellular organismal signaling (GO:0035637)2.89038391
74ethanol oxidation (GO:0006069)2.88079109
75CDP-diacylglycerol metabolic process (GO:0046341)2.86032796
76potassium ion transmembrane transport (GO:0071805)2.78513110
77cellular potassium ion transport (GO:0071804)2.78513110
78microtubule severing (GO:0051013)2.78365316
79cilium morphogenesis (GO:0060271)2.74923249
80negative regulation of cell size (GO:0045792)2.74648816
81peptide hormone processing (GO:0016486)2.74648542
82regulation of skeletal muscle contraction (GO:0014819)2.69878538
83regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.69422101
84renal absorption (GO:0070293)2.67520099
85icosanoid secretion (GO:0032309)2.65013806
86arachidonic acid secretion (GO:0050482)2.65013806
87epithelial cell fate commitment (GO:0072148)2.64475031
88regulation of vacuole organization (GO:0044088)2.64005542
89negative regulation of actin filament depolymerization (GO:0030835)2.63625769
90mitochondrion degradation (GO:0000422)2.62454879
91glomerular epithelial cell development (GO:0072310)2.61836464
92insulin secretion (GO:0030073)2.61690980
93multi-organism reproductive behavior (GO:0044705)2.61072121
94water-soluble vitamin biosynthetic process (GO:0042364)2.60434404
95positive regulation of protein homooligomerization (GO:0032464)2.58672081
96potassium ion transport (GO:0006813)2.58104622
97glomerular visceral epithelial cell development (GO:0072015)2.56665550
98prepulse inhibition (GO:0060134)2.55016772
99digestion (GO:0007586)2.54969206
100potassium ion export (GO:0071435)2.52960937

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.33573683
2GATA1_22025678_ChIP-Seq_K562_Human5.91412914
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.15387944
4IKZF1_21737484_ChIP-ChIP_HCT116_Human3.54221962
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.10506673
6CTBP2_25329375_ChIP-Seq_LNCAP_Human2.03795352
7TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.91654884
8BMI1_23680149_ChIP-Seq_NPCS_Mouse1.82621291
9CTCF_27219007_Chip-Seq_Bcells_Human1.79314592
10CDX2_20551321_ChIP-Seq_CACO-2_Human1.74157891
11* PIAS1_25552417_ChIP-Seq_VCAP_Human1.71074940
12STAT1_20625510_ChIP-Seq_HELA_Human1.63655865
13RNF2_27304074_Chip-Seq_NSC_Mouse1.56873858
14FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.53822884
15FOXO3_23340844_ChIP-Seq_DLD1_Human1.53256270
16STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.50864758
17DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.45720205
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.44248727
19ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.42902559
20CDX2_22108803_ChIP-Seq_LS180_Human1.39518545
21IRF1_19129219_ChIP-ChIP_H3396_Human1.39477007
22SOX2_20726797_ChIP-Seq_SW620_Human1.38041131
23AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.36250077
24CBP_21632823_ChIP-Seq_H3396_Human1.35444229
25GATA6_25053715_ChIP-Seq_YYC3_Human1.33469413
26* FOXA1_25552417_ChIP-Seq_VCAP_Human1.29020557
27FOXH1_21741376_ChIP-Seq_EPCs_Human1.27042657
28EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.22996296
29CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.22975714
30REST_18959480_ChIP-ChIP_MESCs_Mouse1.21807830
31HTT_18923047_ChIP-ChIP_STHdh_Human1.21303653
32SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.19745295
33SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.15594444
34TP53_22573176_ChIP-Seq_HFKS_Human1.14128552
35ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.13887934
36STAT1_17558387_ChIP-Seq_HELA_Human1.13307676
37GATA4_25053715_ChIP-Seq_YYC3_Human1.12897317
38OCT4_20526341_ChIP-Seq_ESCs_Human1.12830912
39RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.11829442
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11141426
41* SA1_27219007_Chip-Seq_Bcells_Human1.10121646
42NCOR_22424771_ChIP-Seq_293T_Human1.07233879
43* FOXA1_25329375_ChIP-Seq_VCAP_Human1.06582761
44* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06582761
45SMC4_20622854_ChIP-Seq_HELA_Human1.06230525
46EZH2_27304074_Chip-Seq_ESCs_Mouse1.05901906
47FLI1_21867929_ChIP-Seq_CD8_Mouse1.03601673
48NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.03288945
49HOXB7_26014856_ChIP-Seq_BT474_Human1.02790648
50ESR1_21235772_ChIP-Seq_MCF-7_Human1.02514989
51RARB_27405468_Chip-Seq_BRAIN_Mouse1.02404669
52ERG_20517297_ChIP-Seq_VCAP_Human1.01632601
53BCL6_27268052_Chip-Seq_Bcells_Human1.01365153
54TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.01225623
55RUNX1_26923725_Chip-Seq_HPCs_Mouse1.00372512
56EZH2_27294783_Chip-Seq_ESCs_Mouse1.00319528
57TCF4_22108803_ChIP-Seq_LS180_Human0.98620581
58FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.98422666
59RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.97425705
60SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.96390053
61IGF1R_20145208_ChIP-Seq_DFB_Human0.95863863
62P68_20966046_ChIP-Seq_HELA_Human0.95521968
63AHR_22903824_ChIP-Seq_MCF-7_Human0.94511400
64ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.93394866
65* SMAD4_21741376_ChIP-Seq_EPCs_Human0.93215016
66RAC3_21632823_ChIP-Seq_H3396_Human0.92928794
67PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.92360044
68RAD21_21589869_ChIP-Seq_MESCs_Mouse0.91685971
69SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91255341
70P53_21459846_ChIP-Seq_SAOS-2_Human0.90999496
71KLF5_20875108_ChIP-Seq_MESCs_Mouse0.90435917
72IRF8_22096565_ChIP-ChIP_GC-B_Human0.90080739
73ELF1_17652178_ChIP-ChIP_JURKAT_Human0.89019603
74* AR_25329375_ChIP-Seq_VCAP_Human0.88609254
75FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88203815
76P300_27268052_Chip-Seq_Bcells_Human0.87590743
77MYC_19829295_ChIP-Seq_ESCs_Human0.85636604
78SOX2_18555785_Chip-Seq_ESCs_Mouse0.84775502
79CBX2_27304074_Chip-Seq_ESCs_Mouse0.84535046
80AR_20517297_ChIP-Seq_VCAP_Human0.84514246
81CTCF_21964334_Chip-Seq_Bcells_Human0.84456612
82FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.83813226
83RACK7_27058665_Chip-Seq_MCF-7_Human0.83752954
84REST_21632747_ChIP-Seq_MESCs_Mouse0.83296188
85BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.83137194
86* CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.82461614
87SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.82399243
88LXR_22158963_ChIP-Seq_LIVER_Mouse0.81646342
89PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.81535453
90PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.80699262
91STAT3_18555785_Chip-Seq_ESCs_Mouse0.79866891
92JARID2_20075857_ChIP-Seq_MESCs_Mouse0.78770913
93PHF8_20622854_ChIP-Seq_HELA_Human0.78526191
94RBPJ_21746931_ChIP-Seq_IB4_Human0.78441728
95RXR_22158963_ChIP-Seq_LIVER_Mouse0.78248927
96CEBPB_22108803_ChIP-Seq_LS180_Human0.77342070
97GATA3_21867929_ChIP-Seq_TH1_Mouse0.77341620
98GATA3_21867929_ChIP-Seq_CD8_Mouse0.77296316
99FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.77133514
100ETV2_25802403_ChIP-Seq_MESCs_Mouse0.76745906

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005645_abnormal_hypothalamus_physiol7.50738308
2MP0010234_abnormal_vibrissa_follicle5.41153418
3MP0004858_abnormal_nervous_system5.09521300
4MP0002139_abnormal_hepatobiliary_system4.65344364
5MP0001986_abnormal_taste_sensitivity4.51997346
6MP0002909_abnormal_adrenal_gland4.01086798
7MP0002837_dystrophic_cardiac_calcinosis3.93720373
8MP0003787_abnormal_imprinting3.34148333
9MP0005423_abnormal_somatic_nervous2.89494030
10MP0003879_abnormal_hair_cell2.87207001
11MP0009780_abnormal_chondrocyte_physiolo2.79281894
12MP0005377_hearing/vestibular/ear_phenot2.53362384
13MP0003878_abnormal_ear_physiology2.53362384
14MP0003123_paternal_imprinting2.44046006
15MP0002138_abnormal_hepatobiliary_system2.41351804
16MP0005379_endocrine/exocrine_gland_phen2.41348136
17MP0008057_abnormal_DNA_replication1.86799054
18MP0008877_abnormal_DNA_methylation1.79350361
19MP0006276_abnormal_autonomic_nervous1.77698010
20MP0009046_muscle_twitch1.72249164
21MP0000003_abnormal_adipose_tissue1.63389884
22MP0010352_gastrointestinal_tract_polyps1.62113382
23MP0000516_abnormal_urinary_system1.61385208
24MP0005367_renal/urinary_system_phenotyp1.61385208
25MP0005220_abnormal_exocrine_pancreas1.55651126
26MP0002254_reproductive_system_inflammat1.51462085
27MP0001485_abnormal_pinna_reflex1.50879239
28MP0004019_abnormal_vitamin_homeostasis1.46515755
29MP0001944_abnormal_pancreas_morphology1.41668900
30MP0005365_abnormal_bile_salt1.36853704
31MP0006036_abnormal_mitochondrial_physio1.31805473
32MP0000013_abnormal_adipose_tissue1.31621610
33MP0006072_abnormal_retinal_apoptosis1.31298593
34MP0002166_altered_tumor_susceptibility1.29755329
35MP0000631_abnormal_neuroendocrine_gland1.24863591
36MP0002163_abnormal_gland_morphology1.21364079
37MP0003868_abnormal_feces_composition1.19176698
38MP0010386_abnormal_urinary_bladder1.15808597
39MP0002693_abnormal_pancreas_physiology1.12407675
40MP0005310_abnormal_salivary_gland1.12327209
41MP0000026_abnormal_inner_ear1.10123425
42MP0010678_abnormal_skin_adnexa1.08705040
43MP0000538_abnormal_urinary_bladder1.05626886
44MP0001666_abnormal_nutrient_absorption1.05413575
45MP0001664_abnormal_digestion1.04259864
46MP0000678_abnormal_parathyroid_gland1.04051508
47MP0005375_adipose_tissue_phenotype1.03469711
48MP0001348_abnormal_lacrimal_gland1.01324440
49MP0010329_abnormal_lipoprotein_level1.01312426
50MP0004145_abnormal_muscle_electrophysio0.98852241
51MP0002078_abnormal_glucose_homeostasis0.97034980
52MP0001756_abnormal_urination0.93138325
53MP0005448_abnormal_energy_balance0.92122720
54MP0004885_abnormal_endolymph0.89525961
55MP0001984_abnormal_olfaction0.88264054
56MP0004270_analgesia0.86902164
57MP0006035_abnormal_mitochondrial_morpho0.84316539
58MP0004036_abnormal_muscle_relaxation0.84142341
59MP0009643_abnormal_urine_homeostasis0.81854701
60MP0003953_abnormal_hormone_level0.79896366
61MP0004215_abnormal_myocardial_fiber0.78303849
62MP0004043_abnormal_pH_regulation0.78210736
63MP0005646_abnormal_pituitary_gland0.77726003
64MP0000230_abnormal_systemic_arterial0.76553096
65MP0008875_abnormal_xenobiotic_pharmacok0.75033366
66MP0002006_tumorigenesis0.74797836
67MP0005332_abnormal_amino_acid0.72203402
68MP0005647_abnormal_sex_gland0.70833400
69MP0001661_extended_life_span0.70536296
70MP0002136_abnormal_kidney_physiology0.70326825
71MP0001545_abnormal_hematopoietic_system0.69589662
72MP0005397_hematopoietic_system_phenotyp0.69589662
73MP0005084_abnormal_gallbladder_morpholo0.69074256
74MP0001765_abnormal_ion_homeostasis0.69017633
75MP0005551_abnormal_eye_electrophysiolog0.66373343
76MP0005319_abnormal_enzyme/_coenzyme0.66000184
77MP0001905_abnormal_dopamine_level0.64526973
78MP0003121_genomic_imprinting0.60704581
79MP0003646_muscle_fatigue0.60616313
80MP0005636_abnormal_mineral_homeostasis0.60516625
81MP0002229_neurodegeneration0.60375071
82MP0000427_abnormal_hair_cycle0.59656671
83MP0002118_abnormal_lipid_homeostasis0.59568791
84MP0005266_abnormal_metabolism0.59347337
85MP0008004_abnormal_stomach_pH0.58999261
86MP0002876_abnormal_thyroid_physiology0.57008086
87MP0002269_muscular_atrophy0.56855621
88MP0005248_abnormal_Harderian_gland0.55918096
89MP0002332_abnormal_exercise_endurance0.55824269
90MP0003075_altered_response_to0.52202100
91MP0002160_abnormal_reproductive_system0.50900894
92MP0002009_preneoplasia0.50833901
93MP0005666_abnormal_adipose_tissue0.48973328
94MP0001764_abnormal_homeostasis0.48717303
95MP0005535_abnormal_body_temperature0.47969393
96MP0005253_abnormal_eye_physiology0.47955095
97MP0004510_myositis0.47049087
98MP0001216_abnormal_epidermal_layer0.46939332
99MP0005334_abnormal_fat_pad0.46790711
100MP0002069_abnormal_eating/drinking_beha0.46418089

Predicted human phenotypes

RankGene SetZ-score
1Pigmentary retinal degeneration (HP:0001146)6.94863230
2Urethral obstruction (HP:0000796)5.21770782
3Severe visual impairment (HP:0001141)4.78021147
4Hypoplasia of the uterus (HP:0000013)4.49350705
5Hyperthyroidism (HP:0000836)4.17844990
6Enlarged penis (HP:0000040)3.97699930
7Aplasia/hypoplasia of the uterus (HP:0008684)3.96479685
8Abnormality of the vitreous humor (HP:0004327)3.79531371
9Abnormality of lateral ventricle (HP:0030047)3.76191504
10Keratoconjunctivitis (HP:0001096)3.56736617
11Keratoconjunctivitis sicca (HP:0001097)3.38691786
12Poor suck (HP:0002033)2.96715627
13Abnormality of aromatic amino acid family metabolism (HP:0004338)2.86864851
14Generalized aminoaciduria (HP:0002909)2.85079993
15Glycosuria (HP:0003076)2.84331012
16Abnormality of urine glucose concentration (HP:0011016)2.84331012
17Tubular atrophy (HP:0000092)2.76290620
18Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.72100697
19Congenital sensorineural hearing impairment (HP:0008527)2.70952243
20Proximal tubulopathy (HP:0000114)2.68772604
21Hematochezia (HP:0002573)2.66059452
22Amelogenesis imperfecta (HP:0000705)2.65395904
23Pendular nystagmus (HP:0012043)2.62279262
24True hermaphroditism (HP:0010459)2.61377791
25Steatorrhea (HP:0002570)2.59584378
26Testicular neoplasm (HP:0010788)2.52081541
27Mesangial abnormality (HP:0001966)2.50747845
28Hyperkalemia (HP:0002153)2.48916649
29Anteriorly placed anus (HP:0001545)2.47539405
30Progressive macrocephaly (HP:0004481)2.43683188
31Abnormal albumin level (HP:0012116)2.38551729
32Hypoalbuminemia (HP:0003073)2.38551729
33Facial shape deformation (HP:0011334)2.37870441
34Potter facies (HP:0002009)2.37870441
35Abnormality of vitamin B metabolism (HP:0004340)2.37122211
36Hypokinesia (HP:0002375)2.33351396
37Male pseudohermaphroditism (HP:0000037)2.33312265
38Abnormal sex determination (HP:0012244)2.32211133
39Sex reversal (HP:0012245)2.32211133
40Congenital malformation of the right heart (HP:0011723)2.31510053
41Double outlet right ventricle (HP:0001719)2.31510053
42Hypoproteinemia (HP:0003075)2.29846344
43Neonatal respiratory distress (HP:0002643)2.29805216
44Abnormality of fatty-acid metabolism (HP:0004359)2.27610438
45Keratitis (HP:0000491)2.27055308
46Choroideremia (HP:0001139)2.24057923
47Popliteal pterygium (HP:0009756)2.23486610
48Azoospermia (HP:0000027)2.21868770
49Horizontal nystagmus (HP:0000666)2.19826308
50Abnormality of chloride homeostasis (HP:0011422)2.19326180
51Hyperglycemia (HP:0003074)2.18287841
52Gout (HP:0001997)2.16734746
53Exocrine pancreatic insufficiency (HP:0001738)2.14860112
54Fat malabsorption (HP:0002630)2.13858749
55Abnormality of vitamin metabolism (HP:0100508)2.13855459
56Agitation (HP:0000713)2.09869650
57Overriding aorta (HP:0002623)2.08847463
58Unilateral renal agenesis (HP:0000122)2.08144094
59Intestinal atresia (HP:0011100)2.04591139
60Pancreatic fibrosis (HP:0100732)2.04387728
61Buphthalmos (HP:0000557)2.04106949
62Dynein arm defect of respiratory motile cilia (HP:0012255)2.03547633
63Absent/shortened dynein arms (HP:0200106)2.03547633
64Asymmetry of the thorax (HP:0001555)2.02431085
65Lymphangioma (HP:0100764)2.02059214
66Vascular calcification (HP:0004934)2.01543094
67Sclerocornea (HP:0000647)2.01147313
68Ketoacidosis (HP:0001993)2.00930633
69Pancreatic cysts (HP:0001737)2.00038098
70Hypobetalipoproteinemia (HP:0003563)1.99141962
71Abnormality of the line of Schwalbe (HP:0008048)1.97287632
72Congenital stationary night blindness (HP:0007642)1.96355231
73Abnormality of dental color (HP:0011073)1.95010751
74Decreased circulating renin level (HP:0003351)1.93549977
75Late onset (HP:0003584)1.92717424
76Conjunctival hamartoma (HP:0100780)1.92222504
77Diminished movement (HP:0002374)1.89082868
78Hyperphosphatemia (HP:0002905)1.89064076
79Hemiparesis (HP:0001269)1.88730629
80Furrowed tongue (HP:0000221)1.87510818
81Malnutrition (HP:0004395)1.86937450
82Myopathic facies (HP:0002058)1.86553708
83Ketosis (HP:0001946)1.86509037
84Tinnitus (HP:0000360)1.84105748
85Insulin-resistant diabetes mellitus (HP:0000831)1.83250823
86Increased CSF protein (HP:0002922)1.80775138
87Nephronophthisis (HP:0000090)1.78882983
88Delayed gross motor development (HP:0002194)1.78681171
89Muscle fiber inclusion bodies (HP:0100299)1.78672180
90Neoplasm of the adrenal cortex (HP:0100641)1.78595357
91Abnormality of the renal cortex (HP:0011035)1.78228622
92Acute necrotizing encephalopathy (HP:0006965)1.77873768
93Bronchiectasis (HP:0002110)1.76230087
94Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.74274899
95Dysautonomia (HP:0002459)1.73317021
96Hyperactive renin-angiotensin system (HP:0000841)1.73075389
97Amblyopia (HP:0000646)1.72983806
98Abnormal respiratory epithelium morphology (HP:0012253)1.71261256
99Abnormal respiratory motile cilium morphology (HP:0005938)1.71261256
100Palpitations (HP:0001962)1.71137473

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.16599109
2MST45.96110238
3PRKD35.76397507
4TEC4.97675570
5MAP4K24.68756745
6ITK4.06269476
7FGFR23.51458193
8PKN23.15809214
9PTK22.77920922
10BTK2.12565127
11MKNK11.99911008
12TRPM71.97345402
13ERBB31.87133082
14RPS6KB21.54381397
15MAP2K61.43315956
16FLT31.41057231
17PHKG21.36671583
18PHKG11.36671583
19FGFR31.35462618
20MAPKAPK51.30010865
21MKNK21.19926525
22OBSCN1.18334314
23EPHA21.15174307
24PRKCI1.12366729
25PAK31.02653495
26LRRK21.02481922
27TAOK11.01377318
28MST1R0.98088065
29STK40.97355549
30GRK10.95277755
31NTRK30.91918963
32STK30.89407116
33STK100.85406110
34FER0.84357397
35STK390.77417880
36PRKCE0.68414369
37IRAK30.66702816
38BMPR1B0.66410745
39MAP2K10.64399400
40LMTK20.61744553
41MAPKAPK30.61693062
42WNK30.61671563
43AKT30.58347649
44OXSR10.57161336
45EIF2AK10.56018412
46CASK0.55179879
47UHMK10.54678014
48PAK40.54616446
49DYRK20.50182131
50MAP2K20.49408310
51TNK20.49174896
52ADRBK20.48977737
53INSRR0.45549839
54STK110.43101787
55PRKD20.42758703
56STK160.41391683
57IRAK20.41076514
58CSNK1G30.40230169
59EEF2K0.39884376
60TRIB30.38181676
61AKT20.37932889
62MAP3K70.36710209
63PINK10.34086824
64HIPK20.33714120
65LIMK10.33139091
66CSNK1G10.31704771
67DAPK20.30585432
68PRKG20.30314224
69BRSK10.30009897
70IRAK40.29037299
71WNK40.28408415
72MET0.26558817
73MAP3K20.25000046
74ROCK10.24852961
75DYRK1B0.23291445
76PRKACA0.23033882
77IGF1R0.22593386
78CAMK2D0.21877899
79PRKAA10.19986801
80SRC0.18798615
81CSNK1G20.18734573
82PRKAA20.18523031
83AURKA0.16992795
84YES10.16603402
85CSNK1A10.16576171
86MAPK110.16195016
87NME10.16040173
88TESK10.15659709
89MARK20.14842957
90NLK0.14725004
91RPS6KA50.14443284
92DYRK30.14265666
93EGFR0.14023565
94PRKCZ0.13969679
95BCKDK0.13187915
96INSR0.12712436
97TBK10.12040229
98PLK10.11933559
99PRKACB0.11655663
100TTK0.11003680

Predicted pathways (KEGG)

RankGene SetZ-score
1Taste transduction_Homo sapiens_hsa047425.06304370
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.19496219
3Renin-angiotensin system_Homo sapiens_hsa046142.69082412
4Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.56953195
5Pancreatic secretion_Homo sapiens_hsa049722.37784487
6Oxidative phosphorylation_Homo sapiens_hsa001902.10097088
7Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.04418309
8Vitamin B6 metabolism_Homo sapiens_hsa007502.00528553
9Sulfur metabolism_Homo sapiens_hsa009202.00467561
10Carbohydrate digestion and absorption_Homo sapiens_hsa049731.96598402
11Phototransduction_Homo sapiens_hsa047441.87387829
12Pentose and glucuronate interconversions_Homo sapiens_hsa000401.87077529
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.75784800
14Linoleic acid metabolism_Homo sapiens_hsa005911.75769269
15Collecting duct acid secretion_Homo sapiens_hsa049661.72621759
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.67677769
17Other glycan degradation_Homo sapiens_hsa005111.65059258
18Arachidonic acid metabolism_Homo sapiens_hsa005901.64803517
19Fat digestion and absorption_Homo sapiens_hsa049751.64478263
20Folate biosynthesis_Homo sapiens_hsa007901.62448511
21Serotonergic synapse_Homo sapiens_hsa047261.59079474
22Propanoate metabolism_Homo sapiens_hsa006401.58030004
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.48724168
24Insulin secretion_Homo sapiens_hsa049111.46849912
25Selenocompound metabolism_Homo sapiens_hsa004501.41718485
26Vibrio cholerae infection_Homo sapiens_hsa051101.37148629
27Parkinsons disease_Homo sapiens_hsa050121.35903797
28Protein digestion and absorption_Homo sapiens_hsa049741.32261073
29Peroxisome_Homo sapiens_hsa041461.31589578
30Caffeine metabolism_Homo sapiens_hsa002321.31504511
31Retinol metabolism_Homo sapiens_hsa008301.29867743
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.28882626
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28556564
34Renin secretion_Homo sapiens_hsa049241.26376828
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.25882288
36Ether lipid metabolism_Homo sapiens_hsa005651.25296537
37Tryptophan metabolism_Homo sapiens_hsa003801.24159707
38Butanoate metabolism_Homo sapiens_hsa006501.23656536
39Sphingolipid metabolism_Homo sapiens_hsa006001.23624516
40Glutathione metabolism_Homo sapiens_hsa004801.21087585
41Chemical carcinogenesis_Homo sapiens_hsa052041.19650708
42Glycerophospholipid metabolism_Homo sapiens_hsa005641.18774820
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.12496653
44Starch and sucrose metabolism_Homo sapiens_hsa005001.10760785
45Synaptic vesicle cycle_Homo sapiens_hsa047211.09216410
46Alzheimers disease_Homo sapiens_hsa050101.06429738
47Ovarian steroidogenesis_Homo sapiens_hsa049131.02015226
48Glucagon signaling pathway_Homo sapiens_hsa049221.01101335
49Cardiac muscle contraction_Homo sapiens_hsa042600.99665388
50Arginine biosynthesis_Homo sapiens_hsa002200.93652824
51Arginine and proline metabolism_Homo sapiens_hsa003300.89964126
52Dopaminergic synapse_Homo sapiens_hsa047280.89180465
53Vitamin digestion and absorption_Homo sapiens_hsa049770.88711631
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.88045908
55Calcium signaling pathway_Homo sapiens_hsa040200.85065224
56ABC transporters_Homo sapiens_hsa020100.82559081
57Sulfur relay system_Homo sapiens_hsa041220.79922473
58Huntingtons disease_Homo sapiens_hsa050160.78973251
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.78216096
60Protein export_Homo sapiens_hsa030600.77734747
61Nitrogen metabolism_Homo sapiens_hsa009100.75847223
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75653087
63Mineral absorption_Homo sapiens_hsa049780.74804301
64Salivary secretion_Homo sapiens_hsa049700.72482069
65Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.72264164
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.70970225
67Circadian rhythm_Homo sapiens_hsa047100.70833691
68Metabolic pathways_Homo sapiens_hsa011000.70457814
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.68089209
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67997816
71Morphine addiction_Homo sapiens_hsa050320.67739233
72Fructose and mannose metabolism_Homo sapiens_hsa000510.67215285
73Tyrosine metabolism_Homo sapiens_hsa003500.65792879
74Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63314437
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.63193939
76Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.61882465
77Gastric acid secretion_Homo sapiens_hsa049710.61679985
78Tight junction_Homo sapiens_hsa045300.60467337
79N-Glycan biosynthesis_Homo sapiens_hsa005100.59993721
80Cholinergic synapse_Homo sapiens_hsa047250.58894815
81Fatty acid degradation_Homo sapiens_hsa000710.58557514
82Histidine metabolism_Homo sapiens_hsa003400.55630669
83Bile secretion_Homo sapiens_hsa049760.55251206
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53422027
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53093578
86Phenylalanine metabolism_Homo sapiens_hsa003600.51209176
87beta-Alanine metabolism_Homo sapiens_hsa004100.48023095
88Glycerolipid metabolism_Homo sapiens_hsa005610.45193066
89Galactose metabolism_Homo sapiens_hsa000520.44863810
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43936498
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43326599
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42377582
93Fatty acid metabolism_Homo sapiens_hsa012120.41857019
94Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.41777282
95Glutamatergic synapse_Homo sapiens_hsa047240.39419917
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39276985
97Aldosterone synthesis and secretion_Homo sapiens_hsa049250.37694350
98GABAergic synapse_Homo sapiens_hsa047270.36657024
99Circadian entrainment_Homo sapiens_hsa047130.36154616
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34215581

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