C11ORF31

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.41033476
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.10951860
3ribosomal small subunit biogenesis (GO:0042274)5.97773834
4chaperone-mediated protein transport (GO:0072321)5.86396436
5viral transcription (GO:0019083)5.85115113
6pyrimidine deoxyribonucleotide catabolic process (GO:0009223)5.65013341
7translational termination (GO:0006415)5.62214263
8ATP synthesis coupled proton transport (GO:0015986)5.58025182
9energy coupled proton transport, down electrochemical gradient (GO:0015985)5.58025182
10regulation of mitochondrial translation (GO:0070129)5.23378879
11maturation of SSU-rRNA (GO:0030490)5.23029622
12SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.13783754
13cotranslational protein targeting to membrane (GO:0006613)5.05151298
14protein targeting to ER (GO:0045047)5.03335553
15protein complex biogenesis (GO:0070271)5.02666085
16establishment of protein localization to mitochondrial membrane (GO:0090151)4.95266624
17translational elongation (GO:0006414)4.93987787
18protein localization to endoplasmic reticulum (GO:0070972)4.80950739
19establishment of protein localization to endoplasmic reticulum (GO:0072599)4.80468542
20mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.78767117
21mitochondrial respiratory chain complex assembly (GO:0033108)4.74374035
22pyrimidine nucleotide catabolic process (GO:0006244)4.72325123
23respiratory electron transport chain (GO:0022904)4.72086866
24mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.67191751
25mitochondrial respiratory chain complex I assembly (GO:0032981)4.67191751
26NADH dehydrogenase complex assembly (GO:0010257)4.67191751
27electron transport chain (GO:0022900)4.62177330
28viral life cycle (GO:0019058)4.48898416
29deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.45515703
30pyrimidine deoxyribonucleotide metabolic process (GO:0009219)4.31670051
31nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.30801688
32cellular protein complex disassembly (GO:0043624)4.28415034
33deoxyribonucleotide catabolic process (GO:0009264)4.21869438
34translational initiation (GO:0006413)4.21806530
35proteasome assembly (GO:0043248)4.20788626
36ribosomal large subunit biogenesis (GO:0042273)4.16726009
37translation (GO:0006412)4.12019199
38respiratory chain complex IV assembly (GO:0008535)4.05869839
39base-excision repair, AP site formation (GO:0006285)4.05691701
40deoxyribose phosphate catabolic process (GO:0046386)4.04684841
41cytochrome complex assembly (GO:0017004)4.02896060
42transcription elongation from RNA polymerase III promoter (GO:0006385)3.99906606
43termination of RNA polymerase III transcription (GO:0006386)3.99906606
44pseudouridine synthesis (GO:0001522)3.99024182
45protein targeting to mitochondrion (GO:0006626)3.98979626
46tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.94719500
47RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.94719500
48cellular component biogenesis (GO:0044085)3.90482661
49protein neddylation (GO:0045116)3.86060560
50establishment of protein localization to mitochondrion (GO:0072655)3.76854274
51DNA deamination (GO:0045006)3.75090466
52protein complex disassembly (GO:0043241)3.73864213
53negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.73461786
54ribonucleoprotein complex biogenesis (GO:0022613)3.72975231
55deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.71053476
56nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.62628983
57protein localization to mitochondrion (GO:0070585)3.56807791
58macromolecular complex disassembly (GO:0032984)3.55136503
59exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.54474846
60oxidative phosphorylation (GO:0006119)3.51579762
61metallo-sulfur cluster assembly (GO:0031163)3.49255187
62iron-sulfur cluster assembly (GO:0016226)3.49255187
63GTP biosynthetic process (GO:0006183)3.43969693
64rRNA modification (GO:0000154)3.43893077
65negative regulation of ligase activity (GO:0051352)3.39953466
66negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.39953466
672-deoxyribonucleotide metabolic process (GO:0009394)3.36601585
68positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.35376802
69protein targeting to membrane (GO:0006612)3.34456088
70telomere maintenance via semi-conservative replication (GO:0032201)3.33682292
71rRNA processing (GO:0006364)3.33236982
72regulation of cellular amino acid metabolic process (GO:0006521)3.33220507
73nuclear-transcribed mRNA catabolic process (GO:0000956)3.33187776
74regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.30827500
75chromatin remodeling at centromere (GO:0031055)3.30586293
76establishment of integrated proviral latency (GO:0075713)3.29558352
77deoxyribose phosphate metabolic process (GO:0019692)3.23563880
78pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.23008486
79purine deoxyribonucleotide catabolic process (GO:0009155)3.22207881
80DNA strand elongation involved in DNA replication (GO:0006271)3.21170428
81rRNA metabolic process (GO:0016072)3.20003982
82purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.17406458
83purine nucleoside triphosphate biosynthetic process (GO:0009145)3.17275550
84CENP-A containing nucleosome assembly (GO:0034080)3.14287613
85mRNA catabolic process (GO:0006402)3.14119387
86DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.13490103
87anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.11537050
88spliceosomal snRNP assembly (GO:0000387)3.10392923
89ATP biosynthetic process (GO:0006754)3.09018068
90pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.08859027
91establishment of viral latency (GO:0019043)3.07513491
92UTP biosynthetic process (GO:0006228)3.05562707
93signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.04992267
94signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.04992267
95signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.04992267
96DNA strand elongation (GO:0022616)3.04303756
97intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.03498054
98signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.03498054
99protein maturation by protein folding (GO:0022417)3.02517636
100RNA catabolic process (GO:0006401)3.01981064

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.37846524
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.08811117
3JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.00507340
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.95186422
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.69259451
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.57119810
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.53525887
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.52071200
9* ETS1_20019798_ChIP-Seq_JURKAT_Human3.48865133
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.39092281
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.14316876
12MYC_18358816_ChIP-ChIP_MESCs_Mouse3.11197399
13CREB1_15753290_ChIP-ChIP_HEK293T_Human3.08119927
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.94330342
15E2F7_22180533_ChIP-Seq_HELA_Human2.93267098
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.85291723
17* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.78939325
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.59996765
19THAP11_20581084_ChIP-Seq_MESCs_Mouse2.56326675
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.55834111
21* VDR_23849224_ChIP-Seq_CD4+_Human2.48850553
22FOXP3_21729870_ChIP-Seq_TREG_Human2.43577971
23MYC_19079543_ChIP-ChIP_MESCs_Mouse2.39162458
24XRN2_22483619_ChIP-Seq_HELA_Human2.36328035
25SRF_21415370_ChIP-Seq_HL-1_Mouse2.35974293
26GABP_19822575_ChIP-Seq_HepG2_Human2.28227498
27PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.27429257
28E2F1_18555785_ChIP-Seq_MESCs_Mouse2.20755453
29* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.08354795
30TTF2_22483619_ChIP-Seq_HELA_Human2.08123964
31YY1_21170310_ChIP-Seq_MESCs_Mouse2.00858742
32* DCP1A_22483619_ChIP-Seq_HELA_Human1.96368848
33NELFA_20434984_ChIP-Seq_ESCs_Mouse1.95800226
34CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.92887308
35ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.89191112
36ELK1_19687146_ChIP-ChIP_HELA_Human1.84261773
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.77635390
38TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.77428619
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.75830469
40* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.72823550
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.69958760
42FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.67887306
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.64448014
44CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.59499573
45CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.51375725
46MYC_18940864_ChIP-ChIP_HL60_Human1.50577692
47POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.48986442
48HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.46737562
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.44694311
50CIITA_25753668_ChIP-Seq_RAJI_Human1.41321144
51BP1_19119308_ChIP-ChIP_Hs578T_Human1.39415560
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.37101465
53ERG_20887958_ChIP-Seq_HPC-7_Mouse1.34703624
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34693656
55BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.31879887
56CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.30980284
57YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27652781
58CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.27431845
59CTCF_18555785_ChIP-Seq_MESCs_Mouse1.26616266
60ZFX_18555785_ChIP-Seq_MESCs_Mouse1.26119681
61* KDM5A_27292631_Chip-Seq_BREAST_Human1.25672229
62SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.24680681
63MYCN_18555785_ChIP-Seq_MESCs_Mouse1.21075196
64MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.20287885
65SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.18147628
66FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.14052436
67* FOXP1_21924763_ChIP-Seq_HESCs_Human1.13955228
68E2F1_21310950_ChIP-Seq_MCF-7_Human1.13316249
69* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13241465
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11844634
71PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.11633109
72SRY_22984422_ChIP-ChIP_TESTIS_Rat1.08197908
73NANOG_18555785_ChIP-Seq_MESCs_Mouse1.07904972
74* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07111504
75KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05520343
76CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02389440
77IRF1_19129219_ChIP-ChIP_H3396_Human0.99844476
78TET1_21451524_ChIP-Seq_MESCs_Mouse0.99555085
79ELK1_22589737_ChIP-Seq_MCF10A_Human0.98938837
80CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98484781
81BCL6_27268052_Chip-Seq_Bcells_Human0.97387103
82EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.96717371
83GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95369863
84PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94762270
85ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.94475900
86FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93053866
87SOX2_18555785_ChIP-Seq_MESCs_Mouse0.93034219
88SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.92205113
89ELF1_20517297_ChIP-Seq_JURKAT_Human0.92033539
90ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91190939
91TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90636548
92RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.88856003
93CTCF_26484167_Chip-Seq_Bcells_Mouse0.88048237
94YY1_22570637_ChIP-Seq_MALME-3M_Human0.87943239
95* VDR_21846776_ChIP-Seq_THP-1_Human0.86704361
96PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.84933338
97CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.84062076
98SOX2_16153702_ChIP-ChIP_HESCs_Human0.83217084
99HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.79502620
100NOTCH1_21737748_ChIP-Seq_TLL_Human0.77728931

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.05982072
2MP0006292_abnormal_olfactory_placode4.15987443
3MP0008058_abnormal_DNA_repair3.49631956
4MP0003806_abnormal_nucleotide_metabolis3.23042079
5MP0003693_abnormal_embryo_hatching3.20405862
6MP0003186_abnormal_redox_activity2.95853500
7MP0010094_abnormal_chromosome_stability2.67647102
8MP0006036_abnormal_mitochondrial_physio2.61559595
9MP0002653_abnormal_ependyma_morphology2.57586875
10MP0008789_abnormal_olfactory_epithelium2.48920577
11MP0004957_abnormal_blastocyst_morpholog2.47192332
12MP0000372_irregular_coat_pigmentation2.32506310
13MP0003111_abnormal_nucleus_morphology2.28044534
14MP0008877_abnormal_DNA_methylation2.26775842
15MP0003786_premature_aging2.25974533
16MP0004147_increased_porphyrin_level2.01356163
17MP0003718_maternal_effect1.93675834
18MP0008932_abnormal_embryonic_tissue1.92053650
19MP0005394_taste/olfaction_phenotype1.89604598
20MP0005499_abnormal_olfactory_system1.89604598
21MP0003077_abnormal_cell_cycle1.87698190
22MP0005084_abnormal_gallbladder_morpholo1.82293700
23MP0002163_abnormal_gland_morphology1.74763142
24MP0006035_abnormal_mitochondrial_morpho1.73922466
25MP0003136_yellow_coat_color1.67486661
26MP0001905_abnormal_dopamine_level1.65497481
27MP0008007_abnormal_cellular_replicative1.58737751
28MP0001293_anophthalmia1.54644354
29MP0002938_white_spotting1.54185382
30MP0005075_abnormal_melanosome_morpholog1.52520309
31MP0008995_early_reproductive_senescence1.43732601
32MP0002160_abnormal_reproductive_system1.42733678
33MP0006072_abnormal_retinal_apoptosis1.41056434
34MP0003787_abnormal_imprinting1.39885790
35MP0001529_abnormal_vocalization1.36832026
36MP0002095_abnormal_skin_pigmentation1.35239212
37MP0001764_abnormal_homeostasis1.31360379
38MP0003123_paternal_imprinting1.30032475
39MP0005645_abnormal_hypothalamus_physiol1.24958881
40MP0002736_abnormal_nociception_after1.24311663
41MP0005671_abnormal_response_to1.20588653
42MP0002210_abnormal_sex_determination1.19962754
43MP0005389_reproductive_system_phenotype1.18186778
44MP0003011_delayed_dark_adaptation1.17913302
45MP0002837_dystrophic_cardiac_calcinosis1.17879685
46MP0010030_abnormal_orbit_morphology1.16278711
47MP0009333_abnormal_splenocyte_physiolog1.15493579
48MP0008872_abnormal_physiological_respon1.14867734
49MP0000358_abnormal_cell_content/1.14099217
50MP0004142_abnormal_muscle_tone1.13676815
51MP0002277_abnormal_respiratory_mucosa1.11376602
52MP0008875_abnormal_xenobiotic_pharmacok1.09585257
53MP0001968_abnormal_touch/_nociception1.02297846
54MP0003121_genomic_imprinting1.01050073
55MP0001485_abnormal_pinna_reflex1.01023284
56MP0000049_abnormal_middle_ear1.00727455
57MP0001145_abnormal_male_reproductive0.98997803
58MP0005379_endocrine/exocrine_gland_phen0.98021916
59MP0002638_abnormal_pupillary_reflex0.97432878
60MP0000313_abnormal_cell_death0.96841075
61MP0001929_abnormal_gametogenesis0.94801370
62MP0000653_abnormal_sex_gland0.93273229
63MP0000490_abnormal_crypts_of0.91282374
64MP0003878_abnormal_ear_physiology0.91156531
65MP0005377_hearing/vestibular/ear_phenot0.91156531
66MP0001984_abnormal_olfaction0.90872617
67MP0002019_abnormal_tumor_incidence0.90714897
68MP0001986_abnormal_taste_sensitivity0.90077451
69MP0001188_hyperpigmentation0.89776960
70MP0009697_abnormal_copulation0.88968381
71MP0002148_abnormal_hypersensitivity_rea0.87829749
72MP0002102_abnormal_ear_morphology0.86032595
73MP0001119_abnormal_female_reproductive0.85964094
74MP0003315_abnormal_perineum_morphology0.85454693
75MP0005636_abnormal_mineral_homeostasis0.84768301
76MP0000631_abnormal_neuroendocrine_gland0.83336082
77MP0005174_abnormal_tail_pigmentation0.82093356
78MP0004133_heterotaxia0.81961220
79MP0001919_abnormal_reproductive_system0.78948554
80MP0005646_abnormal_pituitary_gland0.78734916
81MP0002132_abnormal_respiratory_system0.78659531
82MP0005410_abnormal_fertilization0.78173428
83MP0006276_abnormal_autonomic_nervous0.77861191
84MP0001853_heart_inflammation0.74573186
85MP0002138_abnormal_hepatobiliary_system0.72221075
86MP0005551_abnormal_eye_electrophysiolog0.71843983
87MP0001881_abnormal_mammary_gland0.68953103
88MP0000350_abnormal_cell_proliferation0.68162129
89MP0000689_abnormal_spleen_morphology0.67208965
90MP0003698_abnormal_male_reproductive0.66267469
91MP0005332_abnormal_amino_acid0.66188701
92MP0002429_abnormal_blood_cell0.62429619
93MP0001727_abnormal_embryo_implantation0.62395520
94MP0001545_abnormal_hematopoietic_system0.62243187
95MP0005397_hematopoietic_system_phenotyp0.62243187
96MP0009765_abnormal_xenobiotic_induced0.61902197
97MP0005253_abnormal_eye_physiology0.60437614
98MP0001835_abnormal_antigen_presentation0.60050863
99MP0008873_increased_physiological_sensi0.58963912
100MP0005220_abnormal_exocrine_pancreas0.58711814

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.96334511
2Abnormal mitochondria in muscle tissue (HP:0008316)5.71544673
3Mitochondrial inheritance (HP:0001427)5.44209537
4Acute encephalopathy (HP:0006846)5.37919273
5Hepatocellular necrosis (HP:0001404)5.04285737
6Increased CSF lactate (HP:0002490)4.81704562
7Progressive macrocephaly (HP:0004481)4.78568849
8Hepatic necrosis (HP:0002605)4.53629328
9Abnormality of cells of the erythroid lineage (HP:0012130)4.42350302
10Reticulocytopenia (HP:0001896)4.28844412
11Increased hepatocellular lipid droplets (HP:0006565)4.19563341
12Abnormal number of erythroid precursors (HP:0012131)4.18810609
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.10018852
14Decreased activity of mitochondrial respiratory chain (HP:0008972)4.10018852
15Increased intramyocellular lipid droplets (HP:0012240)4.00868765
16Lipid accumulation in hepatocytes (HP:0006561)3.98996849
17Cerebral edema (HP:0002181)3.95171410
18Renal Fanconi syndrome (HP:0001994)3.71115509
19Increased muscle lipid content (HP:0009058)3.53101585
203-Methylglutaconic aciduria (HP:0003535)3.49437551
21Lactic acidosis (HP:0003128)3.41254797
22Macrocytic anemia (HP:0001972)3.38059768
23Increased serum lactate (HP:0002151)3.36965423
24Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.34024435
25Exercise intolerance (HP:0003546)3.12047771
26Respiratory failure (HP:0002878)3.07839232
27Hyperglycinemia (HP:0002154)3.01689800
28Aplasia/Hypoplasia of the sacrum (HP:0008517)2.98917531
29Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.85265936
30Aplastic anemia (HP:0001915)2.83096287
31Microvesicular hepatic steatosis (HP:0001414)2.74250746
32Exertional dyspnea (HP:0002875)2.73279696
33Pallor (HP:0000980)2.67933356
34Colon cancer (HP:0003003)2.66816710
35Optic disc pallor (HP:0000543)2.65344394
36Type I transferrin isoform profile (HP:0003642)2.61926033
37Leukodystrophy (HP:0002415)2.61880925
38Respiratory difficulties (HP:0002880)2.55392393
39Lethargy (HP:0001254)2.50302855
40Pancytopenia (HP:0001876)2.35141872
41Cleft eyelid (HP:0000625)2.30547068
42Microretrognathia (HP:0000308)2.30544661
43Abnormality of dicarboxylic acid metabolism (HP:0010995)2.29331286
44Dicarboxylic aciduria (HP:0003215)2.29331286
45Multiple enchondromatosis (HP:0005701)2.27073901
46Abnormal protein glycosylation (HP:0012346)2.26295266
47Abnormal glycosylation (HP:0012345)2.26295266
48Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.26295266
49Abnormal protein N-linked glycosylation (HP:0012347)2.26295266
50Absent thumb (HP:0009777)2.25240672
51Abnormality of midbrain morphology (HP:0002418)2.22895078
52Molar tooth sign on MRI (HP:0002419)2.22895078
53CNS demyelination (HP:0007305)2.19305772
54Methylmalonic aciduria (HP:0012120)2.18113123
55Abnormality of renal resorption (HP:0011038)2.16793308
56Pancreatic fibrosis (HP:0100732)2.13467267
57Increased serum pyruvate (HP:0003542)2.12951844
58Emotional lability (HP:0000712)2.09756747
59Progressive microcephaly (HP:0000253)2.04729730
60Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.96205449
61Abnormality of alanine metabolism (HP:0010916)1.96205449
62Hyperalaninemia (HP:0003348)1.96205449
63Testicular atrophy (HP:0000029)1.95304222
64Abnormality of urine glucose concentration (HP:0011016)1.94865417
65Glycosuria (HP:0003076)1.94865417
66Generalized aminoaciduria (HP:0002909)1.93832635
67Abnormality of serum amino acid levels (HP:0003112)1.90711733
68Pancreatic cysts (HP:0001737)1.89350402
69Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.86493820
70Oral leukoplakia (HP:0002745)1.83927668
71Thrombocytosis (HP:0001894)1.83387328
72Cerebral hypomyelination (HP:0006808)1.83175129
73Cerebral palsy (HP:0100021)1.82072455
74Abnormality of the anterior horn cell (HP:0006802)1.80104718
75Degeneration of anterior horn cells (HP:0002398)1.80104718
76Hyperphosphaturia (HP:0003109)1.79205787
77Methylmalonic acidemia (HP:0002912)1.78404364
78Absent rod-and cone-mediated responses on ERG (HP:0007688)1.77605704
79Abnormality of glycolysis (HP:0004366)1.77486769
80Reduced antithrombin III activity (HP:0001976)1.76304845
81Medial flaring of the eyebrow (HP:0010747)1.75601552
82Hyperglycinuria (HP:0003108)1.75286271
83X-linked dominant inheritance (HP:0001423)1.74837779
84Rough bone trabeculation (HP:0100670)1.74783191
85Sclerocornea (HP:0000647)1.73889648
86Myokymia (HP:0002411)1.73683961
87Triphalangeal thumb (HP:0001199)1.72050168
88True hermaphroditism (HP:0010459)1.70271261
89Abnormality of glycine metabolism (HP:0010895)1.67555042
90Abnormality of serine family amino acid metabolism (HP:0010894)1.67555042
91Agammaglobulinemia (HP:0004432)1.67360948
92Neutropenia (HP:0001875)1.66541116
93Blindness (HP:0000618)1.63268324
94Septo-optic dysplasia (HP:0100842)1.62614162
95Gliosis (HP:0002171)1.62116673
96Horseshoe kidney (HP:0000085)1.59983029
97Abnormality of the labia minora (HP:0012880)1.59041070
98Cellular immunodeficiency (HP:0005374)1.58935640
99Vomiting (HP:0002013)1.58100758
100Muscle fiber atrophy (HP:0100295)1.56107161

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.30285968
2NME24.14874614
3BCKDK3.74908135
4TESK23.44558879
5STK163.43150724
6BUB12.98368585
7CDC72.94400500
8ZAK2.82725646
9KDR2.79208654
10VRK12.59374120
11TLK12.46355213
12CDK192.35958989
13PIM22.30095883
14NUAK12.06588692
15ARAF1.99794368
16SRPK11.73896496
17MAP4K21.71564037
18TESK11.64138015
19DYRK21.60978612
20MAP3K111.59665819
21LIMK11.55689531
22ABL21.49582318
23NME11.38330507
24AURKA1.33891847
25SCYL21.31129393
26PBK1.29160448
27NEK11.23700192
28PDK21.23393476
29PLK41.11016569
30RPS6KA51.10727409
31PLK11.07493992
32CSNK1G31.06210136
33TAF11.05946659
34BMPR1B1.03916129
35ATR0.97222617
36AURKB0.97213695
37MST40.94313445
38DAPK10.88291433
39DAPK30.88153282
40MAP2K70.87670939
41CSNK1G20.86429085
42LRRK20.86104123
43PLK30.81750945
44CHEK20.80630365
45DYRK30.80028678
46GRK10.79356028
47WNK30.78469241
48CDK80.77669001
49CSNK1G10.77451278
50MAP4K10.74583575
51BRAF0.70372496
52TRIM280.69284236
53CSNK2A20.69191231
54CSNK2A10.68961287
55TTK0.67845689
56RPS6KA40.65407179
57KIT0.60546815
58CSNK1A1L0.60082532
59MAP3K120.59462377
60PAK10.58440049
61ILK0.58439170
62PRKCI0.58075384
63ADRBK20.57671427
64IKBKB0.57609403
65PRKCQ0.55692726
66PIM10.55157093
67OXSR10.54298569
68EIF2AK10.52859813
69TAOK30.50071263
70CCNB10.46892298
71CDK70.46750079
72TXK0.46468550
73FLT30.43494624
74RPS6KB20.43167087
75INSRR0.41805068
76PASK0.40761902
77CSF1R0.39362799
78STK40.39087295
79TBK10.37017019
80ATM0.36296878
81CHEK10.35990879
82CSNK1A10.35841776
83TAOK20.33460971
84NEK20.32809082
85EIF2AK30.32513928
86GRK50.31905073
87BRSK10.31877659
88MUSK0.31680855
89TIE10.31658093
90PRKCG0.31444380
91TEC0.30888497
92MKNK10.30411680
93MAP3K80.29410940
94TNK20.28425707
95CDK11A0.28412842
96CDK140.27917755
97MAPKAPK30.27098695
98IKBKE0.25211792
99LYN0.24848370
100MAPKAPK50.24429181

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.10542308
2Oxidative phosphorylation_Homo sapiens_hsa001904.21934875
3Proteasome_Homo sapiens_hsa030503.89503052
4Parkinsons disease_Homo sapiens_hsa050123.70092909
5DNA replication_Homo sapiens_hsa030303.35401972
6RNA polymerase_Homo sapiens_hsa030202.96337601
7Mismatch repair_Homo sapiens_hsa034302.83226165
8Huntingtons disease_Homo sapiens_hsa050162.68957325
9Base excision repair_Homo sapiens_hsa034102.68390933
10Homologous recombination_Homo sapiens_hsa034402.40981953
11Alzheimers disease_Homo sapiens_hsa050102.33843659
12Protein export_Homo sapiens_hsa030602.22839535
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.13381342
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.12142709
15Pyrimidine metabolism_Homo sapiens_hsa002402.11346419
16Spliceosome_Homo sapiens_hsa030401.92889937
17Nucleotide excision repair_Homo sapiens_hsa034201.79681916
18Sulfur relay system_Homo sapiens_hsa041221.77086584
19Fanconi anemia pathway_Homo sapiens_hsa034601.65455343
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.64828311
21Cardiac muscle contraction_Homo sapiens_hsa042601.57675798
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.48691127
23One carbon pool by folate_Homo sapiens_hsa006701.48354591
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.46141180
25Fatty acid elongation_Homo sapiens_hsa000621.44978618
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.38462956
27RNA degradation_Homo sapiens_hsa030181.29043866
28RNA transport_Homo sapiens_hsa030131.27882922
29Purine metabolism_Homo sapiens_hsa002301.25638878
30Glutathione metabolism_Homo sapiens_hsa004801.18411524
31Folate biosynthesis_Homo sapiens_hsa007901.16541068
32Primary immunodeficiency_Homo sapiens_hsa053401.14678227
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.09876204
34Non-homologous end-joining_Homo sapiens_hsa034501.09027946
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.08945528
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.06712237
37Systemic lupus erythematosus_Homo sapiens_hsa053221.03347667
38Basal transcription factors_Homo sapiens_hsa030221.02066097
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.98255872
40Asthma_Homo sapiens_hsa053100.95010409
41Peroxisome_Homo sapiens_hsa041460.91949926
42Pyruvate metabolism_Homo sapiens_hsa006200.91492644
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90565160
44Propanoate metabolism_Homo sapiens_hsa006400.89509517
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.87563819
46Metabolic pathways_Homo sapiens_hsa011000.85160247
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.79200219
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75981463
49Carbon metabolism_Homo sapiens_hsa012000.72674772
50Intestinal immune network for IgA production_Homo sapiens_hsa046720.72496236
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.71302351
52Biosynthesis of amino acids_Homo sapiens_hsa012300.69570333
53Sulfur metabolism_Homo sapiens_hsa009200.66154439
54Collecting duct acid secretion_Homo sapiens_hsa049660.61347965
55Allograft rejection_Homo sapiens_hsa053300.59433644
56Cell cycle_Homo sapiens_hsa041100.57773672
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55728512
58Drug metabolism - other enzymes_Homo sapiens_hsa009830.53775528
59Autoimmune thyroid disease_Homo sapiens_hsa053200.53740769
60Antigen processing and presentation_Homo sapiens_hsa046120.53404547
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53369004
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52685300
63Selenocompound metabolism_Homo sapiens_hsa004500.49570426
64Butanoate metabolism_Homo sapiens_hsa006500.48874599
65Graft-versus-host disease_Homo sapiens_hsa053320.48485874
66Pentose phosphate pathway_Homo sapiens_hsa000300.46647310
67Type I diabetes mellitus_Homo sapiens_hsa049400.46111887
68Phototransduction_Homo sapiens_hsa047440.45138341
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44040463
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43538629
71Epstein-Barr virus infection_Homo sapiens_hsa051690.43410563
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42695419
73Alcoholism_Homo sapiens_hsa050340.39670609
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39411508
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.37818570
76Tyrosine metabolism_Homo sapiens_hsa003500.37091339
77Rheumatoid arthritis_Homo sapiens_hsa053230.36617170
78Steroid biosynthesis_Homo sapiens_hsa001000.35152783
79Arachidonic acid metabolism_Homo sapiens_hsa005900.35089974
80Tryptophan metabolism_Homo sapiens_hsa003800.34971889
81p53 signaling pathway_Homo sapiens_hsa041150.34343020
82N-Glycan biosynthesis_Homo sapiens_hsa005100.34207152
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33652299
84Chemical carcinogenesis_Homo sapiens_hsa052040.33651182
85Regulation of autophagy_Homo sapiens_hsa041400.31920839
86mRNA surveillance pathway_Homo sapiens_hsa030150.31676523
87Fatty acid degradation_Homo sapiens_hsa000710.31033149
88Fatty acid metabolism_Homo sapiens_hsa012120.30430126
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.30208148
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29123876
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.26066041
92Phenylalanine metabolism_Homo sapiens_hsa003600.26022541
93Vitamin B6 metabolism_Homo sapiens_hsa007500.25946738
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.25819270
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.25264963
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.23614773
97Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.22236600
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.20858754
99Galactose metabolism_Homo sapiens_hsa000520.20803034
100Caffeine metabolism_Homo sapiens_hsa002320.20795892

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