C11ORF24

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)6.16423681
2Golgi transport vesicle coating (GO:0048200)6.16423681
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.04065792
4protein retention in ER lumen (GO:0006621)5.01871782
5proline biosynthetic process (GO:0006561)4.52502397
6skin morphogenesis (GO:0043589)4.42579532
7protein maturation by protein folding (GO:0022417)4.19047499
8basement membrane organization (GO:0071711)3.98232571
9adhesion of symbiont to host (GO:0044406)3.96015031
10adhesion of symbiont to host cell (GO:0044650)3.92200215
11virion attachment to host cell (GO:0019062)3.92200215
12GDP-mannose metabolic process (GO:0019673)3.89068389
13peptidyl-glutamic acid carboxylation (GO:0017187)3.75512568
14protein carboxylation (GO:0018214)3.75512568
15retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.74612456
16regulation of plasminogen activation (GO:0010755)3.70883158
17proline metabolic process (GO:0006560)3.70423733
18type B pancreatic cell proliferation (GO:0044342)3.56274170
19hemidesmosome assembly (GO:0031581)3.53552660
20COPII vesicle coating (GO:0048208)3.51141401
21regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.50869563
22nucleotide-sugar biosynthetic process (GO:0009226)3.49278830
23very-low-density lipoprotein particle assembly (GO:0034379)3.48620645
24cell adhesion mediated by integrin (GO:0033627)3.46741229
25endodermal cell differentiation (GO:0035987)3.41729099
26regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.34884795
27protein heterotrimerization (GO:0070208)3.32973411
28pinocytosis (GO:0006907)3.28101322
29regulation of extracellular matrix disassembly (GO:0010715)3.26400076
30actin filament depolymerization (GO:0030042)3.23965759
31collagen fibril organization (GO:0030199)3.22315162
32NADH metabolic process (GO:0006734)3.13704389
33negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.13517922
34peptidyl-proline hydroxylation (GO:0019511)3.11658988
354-hydroxyproline metabolic process (GO:0019471)3.10926042
36plasma lipoprotein particle assembly (GO:0034377)3.09660216
37negative regulation of fibrinolysis (GO:0051918)3.08277439
38regulation of early endosome to late endosome transport (GO:2000641)3.06977926
39protein-lipid complex assembly (GO:0065005)3.06558533
40extracellular fibril organization (GO:0043206)3.04245224
41protein localization to endosome (GO:0036010)3.04085840
42barbed-end actin filament capping (GO:0051016)3.03761676
43activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.03461606
44cell-substrate junction assembly (GO:0007044)3.01007652
45hyaluronan catabolic process (GO:0030214)2.98463229
46glutamine family amino acid biosynthetic process (GO:0009084)2.95706332
47urea cycle (GO:0000050)2.93600823
48regulation of metalloenzyme activity (GO:0048552)2.92460492
49positive regulation of nuclease activity (GO:0032075)2.92355105
50UV protection (GO:0009650)2.90651340
51regulation of cholesterol esterification (GO:0010872)2.88629549
52fibril organization (GO:0097435)2.86572732
53vesicle coating (GO:0006901)2.85833024
54endoplasmic reticulum unfolded protein response (GO:0030968)2.81587400
55urea metabolic process (GO:0019627)2.79649896
56protein hydroxylation (GO:0018126)2.79476970
57chondrocyte proliferation (GO:0035988)2.78707649
58regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.78197658
59positive regulation of extracellular matrix organization (GO:1903055)2.77572321
60desmosome organization (GO:0002934)2.76791835
61fibrinolysis (GO:0042730)2.66311747
62regulation of apoptotic process involved in morphogenesis (GO:1902337)2.65870583
63regulation of fibrinolysis (GO:0051917)2.65311448
64endothelial cell morphogenesis (GO:0001886)2.63906006
65stress fiber assembly (GO:0043149)2.63741810
66angiotensin maturation (GO:0002003)2.63514600
67cellular response to unfolded protein (GO:0034620)2.61805934
68regulation of cholesterol homeostasis (GO:2000188)2.60377225
69nitrogen cycle metabolic process (GO:0071941)2.57617324
70nuclear envelope reassembly (GO:0031468)2.56455828
71mitotic nuclear envelope reassembly (GO:0007084)2.56455828
72cellular copper ion homeostasis (GO:0006878)2.55644492
73glycosphingolipid catabolic process (GO:0046479)2.54849884
74ER-nucleus signaling pathway (GO:0006984)2.54641690
75regulation of nuclease activity (GO:0032069)2.54418595
76regulation of mammary gland epithelial cell proliferation (GO:0033599)2.53779934
77apoptotic cell clearance (GO:0043277)2.53564495
78intestinal absorption (GO:0050892)2.52868986
79epithelial cell-cell adhesion (GO:0090136)2.52609505
80nucleobase-containing small molecule interconversion (GO:0015949)2.52129738
81multicellular organismal macromolecule metabolic process (GO:0044259)2.49228691
82positive regulation of pseudopodium assembly (GO:0031274)2.48842395
83negative regulation of smooth muscle cell migration (GO:0014912)2.48070224
84nucleoside diphosphate biosynthetic process (GO:0009133)2.46895201
85collagen metabolic process (GO:0032963)2.46875459
86focal adhesion assembly (GO:0048041)2.46137892
87cell-substrate adherens junction assembly (GO:0007045)2.46137892
88fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.44773139
89cellular response to topologically incorrect protein (GO:0035967)2.43546885
90glucose 6-phosphate metabolic process (GO:0051156)2.41421013
91extracellular matrix disassembly (GO:0022617)2.40359822
92adherens junction assembly (GO:0034333)2.39579051
93positive regulation of blood vessel endothelial cell migration (GO:0043536)2.39288815
94multicellular organismal metabolic process (GO:0044236)2.37802468
95protein N-linked glycosylation via asparagine (GO:0018279)2.37668397
96positive regulation of osteoblast proliferation (GO:0033690)2.37275728
97erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.37103562
98L-phenylalanine metabolic process (GO:0006558)2.37103562
99glycolipid catabolic process (GO:0019377)2.34846162
100peptidyl-asparagine modification (GO:0018196)2.34096738

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.57790938
2RARG_19884340_ChIP-ChIP_MEFs_Mouse3.43393018
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.96949912
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.95604863
5PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.87092720
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.71446147
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.65853184
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.54529780
9ZNF263_19887448_ChIP-Seq_K562_Human2.50258239
10ELK3_25401928_ChIP-Seq_HUVEC_Human2.37541270
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.27662346
12LXR_22292898_ChIP-Seq_THP-1_Human2.16999036
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.12436985
14CLOCK_20551151_ChIP-Seq_293T_Human2.01005409
15RACK7_27058665_Chip-Seq_MCF-7_Human1.93676806
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.89941787
17TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.85676701
18RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.84206592
19TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81507744
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.80955745
21TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78799761
22RXR_22158963_ChIP-Seq_LIVER_Mouse1.78455810
23DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.77202841
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.74871416
25MYC_18555785_ChIP-Seq_MESCs_Mouse1.72321262
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.70052395
27HIF1A_21447827_ChIP-Seq_MCF-7_Human1.67292491
28MYC_18358816_ChIP-ChIP_MESCs_Mouse1.65167417
29KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.63772292
30PPARA_22158963_ChIP-Seq_LIVER_Mouse1.61353082
31TET1_21451524_ChIP-Seq_MESCs_Mouse1.59123288
32ATF3_27146783_Chip-Seq_COLON_Human1.58074756
33CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.57580635
34KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.55729687
35UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.50469462
36POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.48856974
37JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.48253792
38E2F7_22180533_ChIP-Seq_HELA_Human1.45637520
39KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.44677340
40TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.43069820
41HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.42905009
42ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.41262706
43SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.40648819
44ZFX_18555785_ChIP-Seq_MESCs_Mouse1.40647278
45KLF4_18555785_ChIP-Seq_MESCs_Mouse1.40360219
46VDR_21846776_ChIP-Seq_THP-1_Human1.39966118
47SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.39049465
48AR_21909140_ChIP-Seq_LNCAP_Human1.38532286
49CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.36218581
50P300_27058665_Chip-Seq_ZR-75-30cells_Human1.35848526
51NELFA_20434984_ChIP-Seq_ESCs_Mouse1.35429161
52NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.35323264
53TP53_22127205_ChIP-Seq_IMR90_Human1.33316505
54CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.30453940
55SRY_22984422_ChIP-ChIP_TESTIS_Rat1.30316133
56ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.29890566
57E2F1_18555785_ChIP-Seq_MESCs_Mouse1.27693003
58MYC_19079543_ChIP-ChIP_MESCs_Mouse1.27673709
59MYC_19030024_ChIP-ChIP_MESCs_Mouse1.27033644
60MYC_22102868_ChIP-Seq_BL_Human1.25181355
61STAT3_1855785_ChIP-Seq_MESCs_Mouse1.24830054
62HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.24074648
63RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.22132806
64* UBF1/2_26484160_Chip-Seq_HMECs_Human1.21782216
65CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.19638908
66DCP1A_22483619_ChIP-Seq_HELA_Human1.19565394
67ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.18311209
68SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.18097684
69XRN2_22483619_ChIP-Seq_HELA_Human1.16958705
70SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14778487
71KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12644017
72THAP11_20581084_ChIP-Seq_MESCs_Mouse1.11211842
73SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.10472770
74NANOG_18555785_ChIP-Seq_MESCs_Mouse1.09833444
75TBX5_21415370_ChIP-Seq_HL-1_Mouse1.09471367
76SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.08191424
77SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.08191424
78SA1_27219007_Chip-Seq_ERYTHROID_Human1.05760190
79SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05546962
80CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04782437
81* GABP_19822575_ChIP-Seq_HepG2_Human1.03893399
82TFEB_21752829_ChIP-Seq_HELA_Human1.03412961
83ESR2_21235772_ChIP-Seq_MCF-7_Human1.02755640
84CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.01673033
85CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01506657
86NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.00728979
87NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.00397120
88SMC1_22415368_ChIP-Seq_MEFs_Mouse0.98009035
89RARA_24833708_ChIP-Seq_LIVER_Mouse0.97380126
90PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97320545
91CTCF_18555785_ChIP-Seq_MESCs_Mouse0.97310594
92CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96921720
93WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.96306301
94P68_20966046_ChIP-Seq_HELA_Human0.96196060
95P63_26484246_Chip-Seq_KERATINOCYTES_Human0.95299584
96EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.95271553
97KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95078580
98CREB1_15753290_ChIP-ChIP_HEK293T_Human0.95073989
99PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.94956616
100SMC3_22415368_ChIP-Seq_MEFs_Mouse0.94178296

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.53217733
2MP0003705_abnormal_hypodermis_morpholog4.01308771
3MP0005360_urolithiasis3.74631346
4MP0005257_abnormal_intraocular_pressure3.57094533
5MP0004272_abnormal_basement_membrane3.45663455
6MP0009840_abnormal_foam_cell3.01543935
7MP0003566_abnormal_cell_adhesion2.78006840
8MP0005275_abnormal_skin_tensile2.68025957
9MP0005058_abnormal_lysosome_morphology2.60562402
10MP0003279_aneurysm2.39337447
11MP0005503_abnormal_tendon_morphology2.34961085
12MP0005451_abnormal_body_composition2.23183665
13MP0002877_abnormal_melanocyte_morpholog2.15643911
14MP0005623_abnormal_meninges_morphology2.15588604
15MP0009384_cardiac_valve_regurgitation2.07029626
16MP0001958_emphysema2.06208588
17MP0004858_abnormal_nervous_system1.99356780
18MP0005023_abnormal_wound_healing1.97528879
19MP0002060_abnormal_skin_morphology1.88109528
20MP0002139_abnormal_hepatobiliary_system1.87326712
21MP0008260_abnormal_autophagy1.74179293
22MP0010030_abnormal_orbit_morphology1.70468292
23MP0003950_abnormal_plasma_membrane1.65534152
24MP0001542_abnormal_bone_strength1.64109744
25MP0005408_hypopigmentation1.60496823
26MP0006054_spinal_hemorrhage1.58407729
27MP0003191_abnormal_cellular_cholesterol1.56339333
28MP0000013_abnormal_adipose_tissue1.51046623
29MP0001849_ear_inflammation1.49803974
30MP0001666_abnormal_nutrient_absorption1.49549707
31MP0010368_abnormal_lymphatic_system1.42744209
32MP0000003_abnormal_adipose_tissue1.40272667
33MP0010352_gastrointestinal_tract_polyps1.39454700
34MP0003091_abnormal_cell_migration1.34447178
35MP0005365_abnormal_bile_salt1.31901303
36MP0000858_altered_metastatic_potential1.30489229
37MP0003941_abnormal_skin_development1.28442047
38MP0000751_myopathy1.27777725
39MP0001243_abnormal_dermal_layer1.24213757
40MP0005508_abnormal_skeleton_morphology1.20428374
41MP0002089_abnormal_postnatal_growth/wei1.20285883
42MP0005085_abnormal_gallbladder_physiolo1.19082722
43MP0000767_abnormal_smooth_muscle1.18142576
44MP0005171_absent_coat_pigmentation1.15127431
45MP0000678_abnormal_parathyroid_gland1.14955083
46MP0005501_abnormal_skin_physiology1.13815245
47MP0005409_darkened_coat_color1.10936204
48MP0002896_abnormal_bone_mineralization1.09994230
49MP0004233_abnormal_muscle_weight1.08859181
50MP0003453_abnormal_keratinocyte_physiol1.07515938
51MP0010234_abnormal_vibrissa_follicle1.04864348
52MP0000762_abnormal_tongue_morphology1.01978562
53MP0009053_abnormal_anal_canal0.95741966
54MP0005197_abnormal_uvea_morphology0.93038312
55MP0003806_abnormal_nucleotide_metabolis0.92401203
56MP0008932_abnormal_embryonic_tissue0.92288323
57MP0002295_abnormal_pulmonary_circulatio0.91089336
58MP0005165_increased_susceptibility_to0.90702062
59MP0001915_intracranial_hemorrhage0.88157123
60MP0002796_impaired_skin_barrier0.86993036
61MP0003186_abnormal_redox_activity0.86729643
62MP0003172_abnormal_lysosome_physiology0.82827111
63MP0001216_abnormal_epidermal_layer0.80816481
64MP0004019_abnormal_vitamin_homeostasis0.80586394
65MP0010329_abnormal_lipoprotein_level0.80306390
66MP0005332_abnormal_amino_acid0.77645446
67MP0000467_abnormal_esophagus_morphology0.77210912
68MP0003868_abnormal_feces_composition0.75795053
69MP0000534_abnormal_ureter_morphology0.74879809
70MP0005621_abnormal_cell_physiology0.73616338
71MP0000490_abnormal_crypts_of0.73180951
72MP0001730_embryonic_growth_arrest0.71861898
73MP0005076_abnormal_cell_differentiation0.70923294
74MP0002254_reproductive_system_inflammat0.69855833
75MP0005390_skeleton_phenotype0.69509982
76MP0001661_extended_life_span0.69342945
77MP0004957_abnormal_blastocyst_morpholog0.68707374
78MP0003448_altered_tumor_morphology0.68269878
79MP0005164_abnormal_response_to0.67082448
80MP0000462_abnormal_digestive_system0.66991042
81MP0003111_abnormal_nucleus_morphology0.66505550
82MP0005375_adipose_tissue_phenotype0.66119126
83MP0009780_abnormal_chondrocyte_physiolo0.65758677
84MP0005193_abnormal_anterior_eye0.65566003
85MP0000538_abnormal_urinary_bladder0.65170225
86MP0001299_abnormal_eye_distance/0.64596229
87MP0003385_abnormal_body_wall0.64586659
88MP0000343_altered_response_to0.64150433
89MP0009250_abnormal_appendicular_skeleto0.63881752
90MP0004264_abnormal_extraembryonic_tissu0.63812403
91MP0005330_cardiomyopathy0.63647353
92MP0001881_abnormal_mammary_gland0.62955107
93MP0005670_abnormal_white_adipose0.62572334
94MP0010771_integument_phenotype0.61983461
95MP0000733_abnormal_muscle_development0.61553748
96MP0003693_abnormal_embryo_hatching0.61497988
97MP0000609_abnormal_liver_physiology0.61293006
98MP0000750_abnormal_muscle_regeneration0.59901998
99MP0003795_abnormal_bone_structure0.59632438
100MP0009333_abnormal_splenocyte_physiolog0.58872042

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)7.00053439
2Protrusio acetabuli (HP:0003179)5.74587922
3Vertebral compression fractures (HP:0002953)3.86271750
4Atrophic scars (HP:0001075)3.62389618
5Ankle contracture (HP:0006466)3.49782158
6Aortic dissection (HP:0002647)3.26244865
7Fragile skin (HP:0001030)3.19069265
8Bladder diverticulum (HP:0000015)3.07752602
9Follicular hyperkeratosis (HP:0007502)3.02343052
10Cervical subluxation (HP:0003308)2.97024686
11Deep venous thrombosis (HP:0002625)2.96957408
12Abnormality of dentin (HP:0010299)2.92703398
13Spinal rigidity (HP:0003306)2.87980135
14Distal upper limb amyotrophy (HP:0007149)2.87978178
15Upper limb amyotrophy (HP:0009129)2.87978178
16Wormian bones (HP:0002645)2.87085496
17Soft skin (HP:0000977)2.86753255
18Blue sclerae (HP:0000592)2.82201083
19Achilles tendon contracture (HP:0001771)2.81512001
20Abnormality of the Achilles tendon (HP:0005109)2.75300723
21Vascular tortuosity (HP:0004948)2.74326051
22Elbow flexion contracture (HP:0002987)2.61579691
23Aortic aneurysm (HP:0004942)2.57416519
24Abnormality of glutamine family amino acid metabolism (HP:0010902)2.54474368
25Shallow orbits (HP:0000586)2.50806146
26Abnormal delivery (HP:0001787)2.49619831
27Genu recurvatum (HP:0002816)2.47361043
28Abnormality of carpal bone ossification (HP:0006257)2.45379124
29Hand muscle atrophy (HP:0009130)2.43740230
30Biconcave vertebral bodies (HP:0004586)2.43450047
31Abnormality of the acetabulum (HP:0003170)2.41712877
32Arterial tortuosity (HP:0005116)2.41203058
33Cardiovascular calcification (HP:0011915)2.38244502
34Mildly elevated creatine phosphokinase (HP:0008180)2.36461354
35Ulnar bowing (HP:0003031)2.33574621
36Nonimmune hydrops fetalis (HP:0001790)2.31572599
37Increased connective tissue (HP:0009025)2.30248358
38Hypobetalipoproteinemia (HP:0003563)2.27830952
39Cholecystitis (HP:0001082)2.26612344
40Abnormal gallbladder physiology (HP:0012438)2.26612344
41Generalized amyotrophy (HP:0003700)2.26065880
42Neonatal short-limb short stature (HP:0008921)2.25630051
43Trismus (HP:0000211)2.24418305
44Osteolytic defects of the hand bones (HP:0009699)2.23218661
45Osteolytic defects of the phalanges of the hand (HP:0009771)2.23218661
46Entropion (HP:0000621)2.22646654
47Xanthomatosis (HP:0000991)2.21743667
48Peritonitis (HP:0002586)2.21610775
49Cerebral aneurysm (HP:0004944)2.19484854
50Dilatation of the ascending aorta (HP:0005111)2.18907453
51Mitral stenosis (HP:0001718)2.17755992
52Systemic lupus erythematosus (HP:0002725)2.15219231
53Type 1 muscle fiber predominance (HP:0003803)2.14697206
54Abnormality of monocarboxylic acid metabolism (HP:0010996)2.13854894
55Hydroxyprolinuria (HP:0003080)2.11395289
56Abnormality of proline metabolism (HP:0010907)2.11395289
57Thin bony cortex (HP:0002753)2.10657824
58Short nail (HP:0001799)2.09469326
59Disproportionate tall stature (HP:0001519)2.08174773
60Slender build (HP:0001533)2.07075149
61Distal lower limb amyotrophy (HP:0008944)2.06014759
62Spondylolisthesis (HP:0003302)2.05583175
63Rough bone trabeculation (HP:0100670)2.05392814
64Abnormal ossification of hand bones (HP:0005921)2.03815020
65Natal tooth (HP:0000695)2.03782186
66Hyperextensible skin (HP:0000974)2.02331455
67Vascular calcification (HP:0004934)2.01618565
68Hypolipoproteinemia (HP:0010981)1.98609094
69Distal lower limb muscle weakness (HP:0009053)1.97473206
70Hemorrhage of the eye (HP:0011885)1.94364213
71Abnormality of the distal phalanges of the toes (HP:0010182)1.94169467
72Abnormality of complement system (HP:0005339)1.93739627
73Hyperacusis (HP:0010780)1.93479892
74Mitral regurgitation (HP:0001653)1.93093245
75Premature skin wrinkling (HP:0100678)1.92405343
76Joint stiffness (HP:0001387)1.92140007
77Reduced subcutaneous adipose tissue (HP:0003758)1.89331867
78Abnormality of the umbilical cord (HP:0010881)1.88183851
79Abnormality of glycolysis (HP:0004366)1.86194889
80Joint laxity (HP:0001388)1.85860850
81Increased variability in muscle fiber diameter (HP:0003557)1.85656667
82Coxa vara (HP:0002812)1.84622419
83Renal duplication (HP:0000075)1.82920054
84Increased serum pyruvate (HP:0003542)1.81057093
85Aneurysm (HP:0002617)1.79192095
86Myocardial infarction (HP:0001658)1.78871876
87Dysostosis multiplex (HP:0000943)1.78551854
88Bowel diverticulosis (HP:0005222)1.77376473
89Breech presentation (HP:0001623)1.77250894
90Mitral valve prolapse (HP:0001634)1.75852012
91Redundant skin (HP:0001582)1.75411221
92Ileus (HP:0002595)1.74959098
93Hypoalphalipoproteinemia (HP:0003233)1.74609606
94Broad metatarsal (HP:0001783)1.73648861
95Prolonged neonatal jaundice (HP:0006579)1.71091903
96Abnormality of skeletal muscle fiber size (HP:0012084)1.71005017
97Abnormality of aromatic amino acid family metabolism (HP:0004338)1.70587737
98Mucopolysacchariduria (HP:0008155)1.70454805
99Urinary glycosaminoglycan excretion (HP:0003541)1.70454805
100Back pain (HP:0003418)1.69503621

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.87900639
2NME23.29740100
3TESK13.19458801
4EPHA22.74628950
5IRAK32.66482969
6TRIB32.63161242
7MST1R2.53202796
8SMG12.41209360
9MYLK2.37366528
10TESK22.32440248
11PAK42.29159251
12PDGFRA2.26352070
13SIK12.24756253
14ARAF2.23944258
15PIM22.18987808
16LIMK12.16082978
17RIPK12.09942591
18PTK22.06409637
19DDR21.83900001
20FGFR41.79874022
21ICK1.78503366
22TAOK21.72483983
23MAP3K31.69476434
24MET1.57464363
25LMTK21.52956818
26BUB11.52852810
27TTN1.44046508
28PRPF4B1.42244632
29EPHB21.38260891
30PRKD21.28309673
31ABL21.27911795
32PAK21.23101242
33VRK21.21759282
34PDK21.16141810
35SCYL21.13056929
36ILK1.10638377
37LATS21.06742934
38CDK121.05434663
39PRKG21.05027378
40NEK91.00255101
41NEK10.98969149
42CDC42BPA0.98413027
43MAP3K80.95364411
44EEF2K0.93197974
45BRAF0.92695470
46PKN20.92388330
47MAPKAPK30.92273063
48NTRK10.91750553
49EIF2AK10.91490262
50ERBB40.90176298
51TGFBR20.84841786
52EPHB10.82242935
53MAP3K110.80874934
54CDK70.79722120
55MAP3K100.79706501
56MAPK110.77004450
57MOS0.76524806
58PTK60.75152669
59FLT30.74492816
60MAP2K30.73244552
61SIK30.70557702
62CDK80.70191702
63DAPK30.68979365
64MTOR0.68904896
65CLK10.64312543
66PAK10.62588749
67KSR20.62207046
68TBK10.61006032
69MAP3K120.59552379
70BRSK10.59432039
71PDPK10.58678741
72STK160.58424515
73STK380.57997010
74BMX0.57188296
75PBK0.55025905
76TYK20.54928657
77BCKDK0.50525242
78MAP3K10.47271208
79STK100.45793585
80MAPKAPK20.45055293
81TTK0.44706663
82AURKA0.43903214
83PRKCI0.43675852
84RPS6KA20.43075134
85LRRK20.42833775
86DMPK0.41293354
87GSK3A0.40953271
88PRKD30.38818443
89TAOK10.37931576
90AURKB0.36230270
91MAP3K130.35622398
92CDK11A0.35619442
93AKT20.34634821
94CDK150.34465378
95ROCK20.33674331
96CDK90.33530650
97CAMK2G0.32309743
98DAPK10.32205767
99CDK180.31672872
100CDK40.29177341

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004603.04719368
2Other glycan degradation_Homo sapiens_hsa005112.84740442
3Sulfur relay system_Homo sapiens_hsa041222.77764717
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.75384152
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.52252687
6Fructose and mannose metabolism_Homo sapiens_hsa000512.48970983
7Galactose metabolism_Homo sapiens_hsa000522.41361083
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.20709202
9Glycosaminoglycan degradation_Homo sapiens_hsa005312.19557049
10Biosynthesis of amino acids_Homo sapiens_hsa012302.16392483
11Sulfur metabolism_Homo sapiens_hsa009202.10184424
12Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.04733332
13Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.02310474
14ECM-receptor interaction_Homo sapiens_hsa045121.89523635
15Arginine biosynthesis_Homo sapiens_hsa002201.88301318
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.87499424
17Fat digestion and absorption_Homo sapiens_hsa049751.78874845
18N-Glycan biosynthesis_Homo sapiens_hsa005101.76978280
19Complement and coagulation cascades_Homo sapiens_hsa046101.74530275
20Pentose phosphate pathway_Homo sapiens_hsa000301.66563955
21Renin-angiotensin system_Homo sapiens_hsa046141.60160400
22Protein digestion and absorption_Homo sapiens_hsa049741.58244822
23Proteasome_Homo sapiens_hsa030501.51909443
24Carbon metabolism_Homo sapiens_hsa012001.47202723
25Vibrio cholerae infection_Homo sapiens_hsa051101.44834575
26Vitamin digestion and absorption_Homo sapiens_hsa049771.44599928
27Bladder cancer_Homo sapiens_hsa052191.42841076
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.40110686
29Arginine and proline metabolism_Homo sapiens_hsa003301.34104941
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.31263595
31Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.28030928
32Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.27508070
33Focal adhesion_Homo sapiens_hsa045101.27454378
34Prion diseases_Homo sapiens_hsa050201.25738451
35Glutathione metabolism_Homo sapiens_hsa004801.25667691
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.20144185
37Central carbon metabolism in cancer_Homo sapiens_hsa052301.19658064
38Phenylalanine metabolism_Homo sapiens_hsa003601.18231120
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.14335883
40PPAR signaling pathway_Homo sapiens_hsa033201.09020410
41Pentose and glucuronate interconversions_Homo sapiens_hsa000401.07138817
42Vitamin B6 metabolism_Homo sapiens_hsa007501.04835841
43Lysosome_Homo sapiens_hsa041421.04386066
44Folate biosynthesis_Homo sapiens_hsa007901.04327704
45Fatty acid elongation_Homo sapiens_hsa000621.02452788
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.02265569
47Sphingolipid metabolism_Homo sapiens_hsa006001.00730505
48Starch and sucrose metabolism_Homo sapiens_hsa005000.99595284
49Small cell lung cancer_Homo sapiens_hsa052220.97711282
50Pyruvate metabolism_Homo sapiens_hsa006200.97389190
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.95792274
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91756873
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.89893355
54Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.88845154
55Proteoglycans in cancer_Homo sapiens_hsa052050.85104598
56Tyrosine metabolism_Homo sapiens_hsa003500.84284926
57Pyrimidine metabolism_Homo sapiens_hsa002400.84017377
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.83661628
59Amoebiasis_Homo sapiens_hsa051460.83281190
60DNA replication_Homo sapiens_hsa030300.81302757
61One carbon pool by folate_Homo sapiens_hsa006700.77937671
62Mineral absorption_Homo sapiens_hsa049780.77656190
63Base excision repair_Homo sapiens_hsa034100.75441607
64Shigellosis_Homo sapiens_hsa051310.75343393
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69507415
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.68677657
67Fatty acid degradation_Homo sapiens_hsa000710.65458031
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63936672
69Chronic myeloid leukemia_Homo sapiens_hsa052200.63102499
70Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.62618930
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60283638
72Bile secretion_Homo sapiens_hsa049760.59419103
73Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55164181
74Thyroid cancer_Homo sapiens_hsa052160.53802885
75Fatty acid metabolism_Homo sapiens_hsa012120.49780874
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45722961
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45529152
78Retinol metabolism_Homo sapiens_hsa008300.44776296
79PI3K-Akt signaling pathway_Homo sapiens_hsa041510.43662982
80Steroid biosynthesis_Homo sapiens_hsa001000.43562541
81Adherens junction_Homo sapiens_hsa045200.43283109
82Metabolic pathways_Homo sapiens_hsa011000.42971354
83Chemical carcinogenesis_Homo sapiens_hsa052040.42061511
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41202821
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.39935429
86Pancreatic cancer_Homo sapiens_hsa052120.39881665
87Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.36397277
88p53 signaling pathway_Homo sapiens_hsa041150.36267174
89Salmonella infection_Homo sapiens_hsa051320.36237656
90Pertussis_Homo sapiens_hsa051330.34932350
91Apoptosis_Homo sapiens_hsa042100.34596375
92Insulin resistance_Homo sapiens_hsa049310.33934276
93AMPK signaling pathway_Homo sapiens_hsa041520.31488864
94Prostate cancer_Homo sapiens_hsa052150.31392823
95Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.31225589
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.29977086
97Endocytosis_Homo sapiens_hsa041440.29471319
98Lysine degradation_Homo sapiens_hsa003100.25244586
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.25131006
100Histidine metabolism_Homo sapiens_hsa003400.22671024

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