C11ORF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.73700040
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.35874870
3protein complex biogenesis (GO:0070271)4.18847891
4ATP synthesis coupled proton transport (GO:0015986)4.18733444
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.18733444
6response to pheromone (GO:0019236)4.14536070
7respiratory chain complex IV assembly (GO:0008535)4.09813205
8mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.02598232
9mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.99299104
10mitochondrial respiratory chain complex I assembly (GO:0032981)3.99299104
11NADH dehydrogenase complex assembly (GO:0010257)3.99299104
12water-soluble vitamin biosynthetic process (GO:0042364)3.97039988
13mitochondrial respiratory chain complex assembly (GO:0033108)3.95100226
14cellular ketone body metabolic process (GO:0046950)3.74687603
15cytochrome complex assembly (GO:0017004)3.63764482
16DNA deamination (GO:0045006)3.57824274
17electron transport chain (GO:0022900)3.52186091
18respiratory electron transport chain (GO:0022904)3.47415662
19protein-cofactor linkage (GO:0018065)3.44336019
20establishment of protein localization to mitochondrial membrane (GO:0090151)3.39880220
21ketone body metabolic process (GO:1902224)3.36113637
22epithelial cilium movement (GO:0003351)3.18955034
23protein neddylation (GO:0045116)3.16066236
24L-fucose catabolic process (GO:0042355)3.14343278
25fucose catabolic process (GO:0019317)3.14343278
26L-fucose metabolic process (GO:0042354)3.14343278
27nonmotile primary cilium assembly (GO:0035058)3.13194166
28protein localization to cilium (GO:0061512)3.11338148
29detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.09834704
30epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.08031016
31indole-containing compound catabolic process (GO:0042436)3.05582658
32indolalkylamine catabolic process (GO:0046218)3.05582658
33tryptophan catabolic process (GO:0006569)3.05582658
34platelet dense granule organization (GO:0060155)3.01216378
35chaperone-mediated protein transport (GO:0072321)2.96539772
36preassembly of GPI anchor in ER membrane (GO:0016254)2.93539021
37axoneme assembly (GO:0035082)2.92569552
38rRNA modification (GO:0000154)2.87047126
39kynurenine metabolic process (GO:0070189)2.84858946
40indolalkylamine metabolic process (GO:0006586)2.80595963
41hydrogen ion transmembrane transport (GO:1902600)2.80004132
42ATP biosynthetic process (GO:0006754)2.79689904
43nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.78005335
44ribosomal small subunit assembly (GO:0000028)2.77222972
45peptidyl-histidine modification (GO:0018202)2.76222416
46maturation of 5.8S rRNA (GO:0000460)2.75852464
47exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.75251957
48detection of light stimulus involved in sensory perception (GO:0050962)2.72822988
49detection of light stimulus involved in visual perception (GO:0050908)2.72822988
50histone H2A acetylation (GO:0043968)2.71978248
51proteasome assembly (GO:0043248)2.69671324
52intraciliary transport (GO:0042073)2.68017423
53tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.66916853
54RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.66916853
55purine nucleoside triphosphate biosynthetic process (GO:0009145)2.65688497
56cilium morphogenesis (GO:0060271)2.65548697
57proton transport (GO:0015992)2.64902359
58regulation of cilium movement (GO:0003352)2.64551160
59purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.64144152
60nephron epithelium morphogenesis (GO:0072088)2.63985185
61nephron tubule morphogenesis (GO:0072078)2.63985185
62termination of RNA polymerase III transcription (GO:0006386)2.63411313
63transcription elongation from RNA polymerase III promoter (GO:0006385)2.63411313
64protein polyglutamylation (GO:0018095)2.61523758
65photoreceptor cell maintenance (GO:0045494)2.59851765
66hydrogen transport (GO:0006818)2.58811400
67sulfation (GO:0051923)2.58190421
68signal peptide processing (GO:0006465)2.57498941
69intracellular protein transmembrane import (GO:0044743)2.57102956
70replication fork processing (GO:0031297)2.56772091
71mannosylation (GO:0097502)2.56532092
72tryptophan metabolic process (GO:0006568)2.55434659
73centriole replication (GO:0007099)2.55028946
74rRNA methylation (GO:0031167)2.53929221
75cilium movement (GO:0003341)2.53526361
76cilium organization (GO:0044782)2.51891842
77pseudouridine synthesis (GO:0001522)2.51285678
78neural tube formation (GO:0001841)2.50998232
79indole-containing compound metabolic process (GO:0042430)2.50454967
80behavioral response to ethanol (GO:0048149)2.49925672
81regulation of glucokinase activity (GO:0033131)2.49916498
82regulation of hexokinase activity (GO:1903299)2.49916498
83L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.49606571
84negative regulation of telomere maintenance (GO:0032205)2.49091126
85protein K6-linked ubiquitination (GO:0085020)2.48639042
86dopamine transport (GO:0015872)2.48215971
87regulation of meiosis I (GO:0060631)2.47216035
88recombinational repair (GO:0000725)2.47037297
89cilium assembly (GO:0042384)2.46884050
90ubiquinone biosynthetic process (GO:0006744)2.46858532
91translational termination (GO:0006415)2.45779365
92SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.45579180
93cotranslational protein targeting to membrane (GO:0006613)2.44315272
94double-strand break repair via homologous recombination (GO:0000724)2.44282054
95DNA damage response, detection of DNA damage (GO:0042769)2.43373714
96protein targeting to ER (GO:0045047)2.38245127
97C-terminal protein amino acid modification (GO:0018410)2.37391977
98aromatic amino acid family catabolic process (GO:0009074)2.37368312
99sperm motility (GO:0030317)2.37336662
100GPI anchor metabolic process (GO:0006505)2.36921494

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.71282100
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.08543708
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.01242757
4VDR_22108803_ChIP-Seq_LS180_Human2.95105762
5* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.81462003
6GBX2_23144817_ChIP-Seq_PC3_Human2.70492906
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.55406953
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.38389605
9IGF1R_20145208_ChIP-Seq_DFB_Human2.36457477
10FUS_26573619_Chip-Seq_HEK293_Human2.28909640
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.27686046
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.26155452
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.24141513
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.17747683
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.16735789
16EWS_26573619_Chip-Seq_HEK293_Human2.16236899
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.06485897
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.05484294
19ELK1_19687146_ChIP-ChIP_HELA_Human2.03739439
20CTBP1_25329375_ChIP-Seq_LNCAP_Human1.99363067
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.86187721
22* MYC_18940864_ChIP-ChIP_HL60_Human1.85290272
23P300_19829295_ChIP-Seq_ESCs_Human1.83958419
24EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.78198704
25TAF15_26573619_Chip-Seq_HEK293_Human1.77090555
26ETS1_20019798_ChIP-Seq_JURKAT_Human1.76766007
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.76478540
28VDR_23849224_ChIP-Seq_CD4+_Human1.75674134
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.73835974
30ER_23166858_ChIP-Seq_MCF-7_Human1.68224642
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68041570
32EZH2_22144423_ChIP-Seq_EOC_Human1.64770164
33JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.63832916
34MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.56973119
35UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.48050605
36TP53_22573176_ChIP-Seq_HFKS_Human1.46726926
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.43560760
38IRF1_19129219_ChIP-ChIP_H3396_Human1.43509752
39SRF_21415370_ChIP-Seq_HL-1_Mouse1.41507201
40FOXA1_27270436_Chip-Seq_PROSTATE_Human1.40135545
41FOXA1_25329375_ChIP-Seq_VCAP_Human1.40135545
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38974110
43NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.37722376
44GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.37340837
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36159662
46CBP_20019798_ChIP-Seq_JUKART_Human1.36159662
47AR_25329375_ChIP-Seq_VCAP_Human1.33470695
48HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.32803499
49CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.32228965
50NANOG_19829295_ChIP-Seq_ESCs_Human1.31422139
51SOX2_19829295_ChIP-Seq_ESCs_Human1.31422139
52AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30662591
53BCAT_22108803_ChIP-Seq_LS180_Human1.29057468
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.25582887
55STAT3_23295773_ChIP-Seq_U87_Human1.22994934
56FOXP3_21729870_ChIP-Seq_TREG_Human1.22237531
57KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21026404
58SMAD4_21799915_ChIP-Seq_A2780_Human1.20123099
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.20064564
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19786016
61TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19310321
62PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18482940
63AR_20517297_ChIP-Seq_VCAP_Human1.17926961
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17871357
65NCOR_22424771_ChIP-Seq_293T_Human1.17668954
66CBX2_27304074_Chip-Seq_ESCs_Mouse1.16987021
67TCF4_22108803_ChIP-Seq_LS180_Human1.16986771
68NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16793790
69ETV2_25802403_ChIP-Seq_MESCs_Mouse1.15904396
70EZH2_27294783_Chip-Seq_NPCs_Mouse1.12853710
71GATA3_21878914_ChIP-Seq_MCF-7_Human1.12735686
72FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12303137
73AUTS2_25519132_ChIP-Seq_293T-REX_Human1.10712368
74EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10489074
75NOTCH1_21737748_ChIP-Seq_TLL_Human1.09797913
76TCF4_23295773_ChIP-Seq_U87_Human1.09416080
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08445040
78PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.07390770
79REST_21632747_ChIP-Seq_MESCs_Mouse1.07275337
80CREB1_15753290_ChIP-ChIP_HEK293T_Human1.07201558
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07157099
82SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05481081
83RUNX2_22187159_ChIP-Seq_PCA_Human1.04871768
84FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04817388
85SMAD3_21741376_ChIP-Seq_EPCs_Human1.04207703
86* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04086044
87SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01974380
88POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00822513
89TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00822513
90HTT_18923047_ChIP-ChIP_STHdh_Human1.00537978
91HOXB7_26014856_ChIP-Seq_BT474_Human0.99438256
92RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98791010
93NANOG_18555785_Chip-Seq_ESCs_Mouse0.98649335
94CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.96998309
95PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.96533165
96CRX_20693478_ChIP-Seq_RETINA_Mouse0.96496047
97FLI1_21867929_ChIP-Seq_TH2_Mouse0.95718545
98EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95236770
99RNF2_27304074_Chip-Seq_NSC_Mouse0.94353504
100P53_22387025_ChIP-Seq_ESCs_Mouse0.94299960

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis2.82539879
2MP0008877_abnormal_DNA_methylation2.68996436
3MP0002837_dystrophic_cardiac_calcinosis2.62740393
4MP0006072_abnormal_retinal_apoptosis2.44106784
5MP0005551_abnormal_eye_electrophysiolog2.36835458
6MP0002102_abnormal_ear_morphology2.13478069
7MP0005645_abnormal_hypothalamus_physiol2.12198774
8MP0002938_white_spotting2.09618365
9MP0006292_abnormal_olfactory_placode2.01951674
10MP0003136_yellow_coat_color1.90446757
11MP0004043_abnormal_pH_regulation1.85737468
12MP0001968_abnormal_touch/_nociception1.83270624
13MP0005253_abnormal_eye_physiology1.82679899
14MP0005084_abnormal_gallbladder_morpholo1.82472644
15MP0005646_abnormal_pituitary_gland1.79976987
16MP0003880_abnormal_central_pattern1.79486572
17MP0009379_abnormal_foot_pigmentation1.78184429
18MP0002876_abnormal_thyroid_physiology1.76934061
19MP0002638_abnormal_pupillary_reflex1.75552686
20MP0004133_heterotaxia1.74997264
21MP0009046_muscle_twitch1.73459877
22MP0001485_abnormal_pinna_reflex1.72874802
23MP0003787_abnormal_imprinting1.69765196
24MP0008875_abnormal_xenobiotic_pharmacok1.69391483
25MP0002736_abnormal_nociception_after1.63765258
26MP0004142_abnormal_muscle_tone1.63226961
27MP0000372_irregular_coat_pigmentation1.62625512
28MP0000631_abnormal_neuroendocrine_gland1.61716361
29MP0008058_abnormal_DNA_repair1.60322886
30MP0008872_abnormal_physiological_respon1.59966787
31MP0004885_abnormal_endolymph1.59217449
32MP0003011_delayed_dark_adaptation1.58645574
33MP0001986_abnormal_taste_sensitivity1.53344732
34MP0009745_abnormal_behavioral_response1.50112115
35MP0002163_abnormal_gland_morphology1.48330654
36MP0003718_maternal_effect1.45812542
37MP0004147_increased_porphyrin_level1.45096349
38MP0002653_abnormal_ependyma_morphology1.45047387
39MP0010386_abnormal_urinary_bladder1.42243582
40MP0002272_abnormal_nervous_system1.41281873
41MP0005379_endocrine/exocrine_gland_phen1.40843239
42MP0002160_abnormal_reproductive_system1.38740390
43MP0003283_abnormal_digestive_organ1.36327790
44MP0006276_abnormal_autonomic_nervous1.35052483
45MP0003878_abnormal_ear_physiology1.32138853
46MP0005377_hearing/vestibular/ear_phenot1.32138853
47MP0000427_abnormal_hair_cycle1.29993666
48MP0001984_abnormal_olfaction1.28942962
49MP0001764_abnormal_homeostasis1.27528355
50MP0008995_early_reproductive_senescence1.26744208
51MP0001486_abnormal_startle_reflex1.23045809
52MP0005389_reproductive_system_phenotype1.22982202
53MP0003646_muscle_fatigue1.21569808
54MP0006036_abnormal_mitochondrial_physio1.19659244
55MP0002735_abnormal_chemical_nociception1.18669623
56MP0001529_abnormal_vocalization1.18540339
57MP0002928_abnormal_bile_duct1.18124652
58MP0004742_abnormal_vestibular_system1.13109437
59MP0002234_abnormal_pharynx_morphology1.13095033
60MP0005410_abnormal_fertilization1.11382465
61MP0005332_abnormal_amino_acid1.11381500
62MP0002557_abnormal_social/conspecific_i1.08994367
63MP0003786_premature_aging1.08973306
64MP0005174_abnormal_tail_pigmentation1.08853598
65MP0001501_abnormal_sleep_pattern1.07914999
66MP0004215_abnormal_myocardial_fiber1.07047943
67MP0003121_genomic_imprinting1.06590155
68MP0005195_abnormal_posterior_eye1.05810720
69MP0001905_abnormal_dopamine_level1.04129001
70MP0009697_abnormal_copulation1.02707144
71MP0004145_abnormal_muscle_electrophysio1.02586851
72MP0001970_abnormal_pain_threshold1.01890548
73MP0001944_abnormal_pancreas_morphology1.00335463
74MP0008789_abnormal_olfactory_epithelium0.99545903
75MP0002733_abnormal_thermal_nociception0.99430810
76MP0002095_abnormal_skin_pigmentation0.99146165
77MP0001919_abnormal_reproductive_system0.98978798
78MP0003693_abnormal_embryo_hatching0.98957636
79MP0005075_abnormal_melanosome_morpholog0.98623116
80MP0002572_abnormal_emotion/affect_behav0.97722488
81MP0000569_abnormal_digit_pigmentation0.97558485
82MP0003698_abnormal_male_reproductive0.96650665
83MP0002693_abnormal_pancreas_physiology0.94613449
84MP0003186_abnormal_redox_activity0.94574173
85MP0001293_anophthalmia0.94196654
86MP0002138_abnormal_hepatobiliary_system0.93657986
87MP0001929_abnormal_gametogenesis0.93594607
88MP0000026_abnormal_inner_ear0.93462624
89MP0002210_abnormal_sex_determination0.91850194
90MP0002064_seizures0.91292343
91MP0003122_maternal_imprinting0.90912864
92MP0002751_abnormal_autonomic_nervous0.90604126
93MP0005220_abnormal_exocrine_pancreas0.90314792
94MP0002277_abnormal_respiratory_mucosa0.90170122
95MP0002067_abnormal_sensory_capabilities0.89078723
96MP0002184_abnormal_innervation0.86099689
97MP0005085_abnormal_gallbladder_physiolo0.86001281
98MP0002752_abnormal_somatic_nervous0.85606253
99MP0005636_abnormal_mineral_homeostasis0.85195282
100MP0001963_abnormal_hearing_physiology0.84257684

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.33734541
2Pancreatic fibrosis (HP:0100732)4.01108880
3True hermaphroditism (HP:0010459)3.99689461
4Abnormality of midbrain morphology (HP:0002418)3.90903946
5Molar tooth sign on MRI (HP:0002419)3.90903946
6Acute necrotizing encephalopathy (HP:0006965)3.52568963
7Nephronophthisis (HP:0000090)3.44610034
8Mitochondrial inheritance (HP:0001427)3.39459717
9Hepatic necrosis (HP:0002605)3.31996641
10Hepatocellular necrosis (HP:0001404)3.29867959
11Congenital stationary night blindness (HP:0007642)3.17919017
12Progressive macrocephaly (HP:0004481)3.16259110
13Increased CSF lactate (HP:0002490)3.13604342
14Acute encephalopathy (HP:0006846)3.10848137
15Abnormal mitochondria in muscle tissue (HP:0008316)3.06652459
16Pendular nystagmus (HP:0012043)3.03877964
17Medial flaring of the eyebrow (HP:0010747)3.01177824
18Abnormality of the renal medulla (HP:0100957)2.92779186
19Abnormality of the renal cortex (HP:0011035)2.92345114
20Sclerocornea (HP:0000647)2.72588259
21Cystic liver disease (HP:0006706)2.72031172
223-Methylglutaconic aciduria (HP:0003535)2.58534858
23Type II lissencephaly (HP:0007260)2.56572972
24Abnormal rod and cone electroretinograms (HP:0008323)2.54535605
25Generalized aminoaciduria (HP:0002909)2.53470032
26Abolished electroretinogram (ERG) (HP:0000550)2.53316861
27Renal cortical cysts (HP:0000803)2.49255546
28Congenital primary aphakia (HP:0007707)2.48283623
29Increased hepatocellular lipid droplets (HP:0006565)2.48159359
30Attenuation of retinal blood vessels (HP:0007843)2.44801134
31Gait imbalance (HP:0002141)2.44204439
32Methylmalonic acidemia (HP:0002912)2.40798884
33Hypothermia (HP:0002045)2.37867870
34Nephrogenic diabetes insipidus (HP:0009806)2.37183788
35Lipid accumulation in hepatocytes (HP:0006561)2.37163192
36Male pseudohermaphroditism (HP:0000037)2.31409805
37Chronic hepatic failure (HP:0100626)2.30168188
38Absent rod-and cone-mediated responses on ERG (HP:0007688)2.26368708
39Abnormal number of erythroid precursors (HP:0012131)2.22384003
40Anencephaly (HP:0002323)2.22195834
41Furrowed tongue (HP:0000221)2.21309958
42Aplasia/Hypoplasia of the tongue (HP:0010295)2.20983295
43Cerebral edema (HP:0002181)2.19251904
44Increased serum lactate (HP:0002151)2.17771952
45Polydipsia (HP:0001959)2.16199013
46Abnormal drinking behavior (HP:0030082)2.16199013
47Tubular atrophy (HP:0000092)2.15221651
48Renal Fanconi syndrome (HP:0001994)2.14713395
49Methylmalonic aciduria (HP:0012120)2.12978182
50Optic disc pallor (HP:0000543)2.11347826
51Congenital, generalized hypertrichosis (HP:0004540)2.09497732
52Lactic acidosis (HP:0003128)2.07686910
53Ketoacidosis (HP:0001993)2.06117944
54Abnormality of cells of the erythroid lineage (HP:0012130)2.05961504
55Glycosuria (HP:0003076)2.05722363
56Abnormality of urine glucose concentration (HP:0011016)2.05722363
57Genital tract atresia (HP:0001827)2.05519530
58Decreased central vision (HP:0007663)2.03000956
59Congenital hepatic fibrosis (HP:0002612)2.02804464
60Colon cancer (HP:0003003)1.99650071
61Large for gestational age (HP:0001520)1.99608627
62Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.99382882
63Hyperventilation (HP:0002883)1.98994568
64Vaginal atresia (HP:0000148)1.98635357
65Intestinal atresia (HP:0011100)1.96691681
66Postaxial foot polydactyly (HP:0001830)1.96435251
67Abnormality of macular pigmentation (HP:0008002)1.96424719
68Dynein arm defect of respiratory motile cilia (HP:0012255)1.95338004
69Absent/shortened dynein arms (HP:0200106)1.95338004
70Abnormal respiratory epithelium morphology (HP:0012253)1.93430248
71Abnormal respiratory motile cilium morphology (HP:0005938)1.93430248
72Congenital sensorineural hearing impairment (HP:0008527)1.92963100
73Respiratory failure (HP:0002878)1.89879718
74Abnormal ciliary motility (HP:0012262)1.87429254
75Polyuria (HP:0000103)1.85197722
76Abnormality of alanine metabolism (HP:0010916)1.85032470
77Hyperalaninemia (HP:0003348)1.85032470
78Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.85032470
79Severe visual impairment (HP:0001141)1.84283961
80Ketosis (HP:0001946)1.83302629
81Abnormality of the labia minora (HP:0012880)1.83064012
82Optic nerve hypoplasia (HP:0000609)1.81669601
83Abnormal biliary tract physiology (HP:0012439)1.81138462
84Bile duct proliferation (HP:0001408)1.81138462
85Aplasia/Hypoplasia of the uvula (HP:0010293)1.80932151
86Hyperglycinemia (HP:0002154)1.79634178
87Increased corneal curvature (HP:0100692)1.79119087
88Keratoconus (HP:0000563)1.79119087
89Abnormality of vitamin B metabolism (HP:0004340)1.77201050
90Lissencephaly (HP:0001339)1.77094196
91Postaxial hand polydactyly (HP:0001162)1.76489443
92Abnormality of renal resorption (HP:0011038)1.75740953
93Lethargy (HP:0001254)1.75370745
94Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.73352449
95Decreased activity of mitochondrial respiratory chain (HP:0008972)1.73352449
96Hypoglycemic coma (HP:0001325)1.73159633
97CNS demyelination (HP:0007305)1.71329128
98Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.70880571
99Preaxial hand polydactyly (HP:0001177)1.70260876
100Tachypnea (HP:0002789)1.69746211

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.95463690
2NUAK12.79930971
3BMPR1B2.77313266
4ADRBK22.73083025
5WNK32.61512096
6ZAK2.60382343
7MAP4K22.43916553
8GRK12.22479480
9WNK42.00181461
10VRK21.99813375
11INSRR1.97698160
12ACVR1B1.86506096
13MST41.75243984
14CDK191.66384691
15TLK11.63370423
16TNIK1.62520850
17CASK1.54654243
18OXSR11.50615755
19DAPK21.47854675
20STK161.43725885
21NME11.42258628
22VRK11.41814893
23TAOK31.40552418
24STK391.38470508
25STK38L1.37534468
26PNCK1.34599135
27MAP3K41.31661196
28MAPK131.29465670
29MKNK21.26878746
30PLK41.25567637
31STK241.22921892
32BCKDK1.17694744
33PINK11.17127398
34PASK1.14397189
35TXK1.14179942
36DYRK21.11712313
37CSNK1G11.10516755
38EIF2AK31.04007474
39PLK31.03946153
40PAK31.01975895
41NTRK30.99585277
42NLK0.98934976
43STK30.96183754
44ADRBK10.95867249
45CDC70.95673730
46TGFBR10.95173226
47PLK20.94947179
48PRKCG0.94638802
49CSNK1G20.91596224
50MKNK10.91417070
51CSNK1G30.90842259
52MAP2K70.89564550
53TRIM280.89171544
54BRSK20.88466786
55BUB10.86131083
56FGFR20.83857524
57WEE10.83102168
58PRKCE0.82673263
59TAF10.80260467
60ERBB30.75209833
61IRAK10.73228779
62MAPKAPK50.72719632
63CSNK1A1L0.69424364
64PLK10.68337534
65PHKG20.67158197
66PHKG10.67158197
67PTK2B0.63237667
68RPS6KA50.62885970
69TEC0.62203500
70MAPK150.61762428
71CDK30.59439629
72CAMKK20.58305318
73EIF2AK10.56730950
74TIE10.55797447
75MAP2K60.52635646
76CSNK1A10.51135831
77AKT30.50219237
78TNK20.48239057
79FLT30.47337912
80MUSK0.47232434
81CAMK2A0.47124605
82NEK10.46822556
83PRKACA0.46226073
84SRPK10.44480752
85CHEK20.43091831
86PIK3CA0.42575602
87AURKA0.41893859
88CAMK10.41691960
89ATR0.41268452
90BCR0.39071271
91GRK50.38429515
92MAPKAPK30.37487178
93STK110.37429998
94FER0.36980750
95DYRK30.36654596
96TSSK60.36153770
97NEK20.35725637
98PRKCQ0.35655373
99RPS6KA40.34536869
100CSNK2A10.34179528

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.51769579
2Protein export_Homo sapiens_hsa030602.90811627
3Parkinsons disease_Homo sapiens_hsa050122.81273309
4Ribosome_Homo sapiens_hsa030102.71266323
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.56132856
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.52719386
7Butanoate metabolism_Homo sapiens_hsa006502.36798149
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.21002615
9Homologous recombination_Homo sapiens_hsa034402.17555294
10Phototransduction_Homo sapiens_hsa047442.06314988
11Proteasome_Homo sapiens_hsa030502.05968439
12RNA polymerase_Homo sapiens_hsa030202.03734919
13Huntingtons disease_Homo sapiens_hsa050161.94934269
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.90872649
15Alzheimers disease_Homo sapiens_hsa050101.88686830
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.75837005
17Linoleic acid metabolism_Homo sapiens_hsa005911.70655248
18Sulfur metabolism_Homo sapiens_hsa009201.62068783
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.60486776
20Selenocompound metabolism_Homo sapiens_hsa004501.59357774
21Cardiac muscle contraction_Homo sapiens_hsa042601.53321791
22Propanoate metabolism_Homo sapiens_hsa006401.52540411
23Nicotine addiction_Homo sapiens_hsa050331.50064990
24Basal transcription factors_Homo sapiens_hsa030221.48984149
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.47426985
26Tryptophan metabolism_Homo sapiens_hsa003801.47316086
27Nitrogen metabolism_Homo sapiens_hsa009101.46475486
28One carbon pool by folate_Homo sapiens_hsa006701.42116324
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.42057492
30Fanconi anemia pathway_Homo sapiens_hsa034601.39316560
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.33028334
32RNA degradation_Homo sapiens_hsa030181.31377212
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.29467927
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.28166466
35Caffeine metabolism_Homo sapiens_hsa002321.27048641
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.25854761
37Peroxisome_Homo sapiens_hsa041461.24513246
38Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.23079839
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.22162511
40Ether lipid metabolism_Homo sapiens_hsa005651.21979697
41Fatty acid elongation_Homo sapiens_hsa000621.19998502
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.14492370
43Chemical carcinogenesis_Homo sapiens_hsa052041.13797790
44Retinol metabolism_Homo sapiens_hsa008301.12494990
45Primary bile acid biosynthesis_Homo sapiens_hsa001201.12376661
46Mismatch repair_Homo sapiens_hsa034301.10850228
47Pentose and glucuronate interconversions_Homo sapiens_hsa000401.05648207
48Taste transduction_Homo sapiens_hsa047421.04185650
49Nucleotide excision repair_Homo sapiens_hsa034201.02719208
50Collecting duct acid secretion_Homo sapiens_hsa049661.02180564
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.98408327
52Purine metabolism_Homo sapiens_hsa002300.95907615
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92415663
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90943720
55Olfactory transduction_Homo sapiens_hsa047400.90840726
56Pyrimidine metabolism_Homo sapiens_hsa002400.88983229
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85450093
58Non-homologous end-joining_Homo sapiens_hsa034500.84239442
59Metabolic pathways_Homo sapiens_hsa011000.82495987
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82280972
61Insulin secretion_Homo sapiens_hsa049110.77824903
62Fatty acid degradation_Homo sapiens_hsa000710.75731137
63Steroid biosynthesis_Homo sapiens_hsa001000.74704553
64Morphine addiction_Homo sapiens_hsa050320.74625388
65Regulation of autophagy_Homo sapiens_hsa041400.73643781
66Arachidonic acid metabolism_Homo sapiens_hsa005900.72680811
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.71049410
68Folate biosynthesis_Homo sapiens_hsa007900.70305022
69RNA transport_Homo sapiens_hsa030130.69022637
70beta-Alanine metabolism_Homo sapiens_hsa004100.66853199
71Sulfur relay system_Homo sapiens_hsa041220.65633426
72Fatty acid metabolism_Homo sapiens_hsa012120.61939587
73ABC transporters_Homo sapiens_hsa020100.61732992
74Serotonergic synapse_Homo sapiens_hsa047260.61027801
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60922450
76Glutathione metabolism_Homo sapiens_hsa004800.59440566
77Fat digestion and absorption_Homo sapiens_hsa049750.59146444
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56228729
79GABAergic synapse_Homo sapiens_hsa047270.55735016
80Circadian entrainment_Homo sapiens_hsa047130.54665335
81Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.53250844
82Base excision repair_Homo sapiens_hsa034100.51875452
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49849598
84Vitamin digestion and absorption_Homo sapiens_hsa049770.47461416
85Glutamatergic synapse_Homo sapiens_hsa047240.47340037
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46774798
87Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.46732296
88Intestinal immune network for IgA production_Homo sapiens_hsa046720.46317822
89Spliceosome_Homo sapiens_hsa030400.44960379
90Glycerolipid metabolism_Homo sapiens_hsa005610.44086176
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.44007416
92DNA replication_Homo sapiens_hsa030300.43187124
93Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.42851311
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40013679
95Ovarian steroidogenesis_Homo sapiens_hsa049130.39019099
96Arginine and proline metabolism_Homo sapiens_hsa003300.38706451
97Cocaine addiction_Homo sapiens_hsa050300.36392348
98Circadian rhythm_Homo sapiens_hsa047100.35944198
99Pyruvate metabolism_Homo sapiens_hsa006200.35560629
100Mineral absorption_Homo sapiens_hsa049780.34800986

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