C10ORF90

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1secondary metabolite biosynthetic process (GO:0044550)9.41075528
2acrosome reaction (GO:0007340)8.36243546
3fusion of sperm to egg plasma membrane (GO:0007342)8.14900051
4axon ensheathment in central nervous system (GO:0032291)7.24263291
5central nervous system myelination (GO:0022010)7.24263291
6response to pheromone (GO:0019236)6.73960699
7plasma membrane fusion (GO:0045026)6.17342669
8sperm motility (GO:0030317)6.12095174
9sperm capacitation (GO:0048240)5.74287293
10calcium ion-dependent exocytosis (GO:0017156)5.28912343
11negative regulation of inclusion body assembly (GO:0090084)5.21884002
12microtubule polymerization or depolymerization (GO:0031109)4.94209802
13protein polyglutamylation (GO:0018095)4.86929376
14melanocyte differentiation (GO:0030318)4.82599381
15ketone body metabolic process (GO:1902224)4.64030685
16long-chain fatty acid biosynthetic process (GO:0042759)4.60194565
17pigment cell differentiation (GO:0050931)4.59742110
18chromosome condensation (GO:0030261)4.47227442
19phenol-containing compound biosynthetic process (GO:0046189)4.31283092
20microtubule depolymerization (GO:0007019)4.22956086
21DNA packaging (GO:0006323)4.21465216
22spermatid development (GO:0007286)4.18899532
23microtubule severing (GO:0051013)4.17763666
24myelin maintenance (GO:0043217)4.08282581
25developmental pigmentation (GO:0048066)4.07167183
26tyrosine metabolic process (GO:0006570)3.83882201
27peripheral nervous system development (GO:0007422)3.81745037
28response to methylmercury (GO:0051597)3.75990052
29cell wall macromolecule metabolic process (GO:0044036)3.72714867
30single strand break repair (GO:0000012)3.70058880
31sperm-egg recognition (GO:0035036)3.67232626
32neuronal ion channel clustering (GO:0045161)3.63226314
33binding of sperm to zona pellucida (GO:0007339)3.58642090
34regulation of inclusion body assembly (GO:0090083)3.57750318
35melanosome organization (GO:0032438)3.42347508
36multicellular organism reproduction (GO:0032504)3.41701151
37astrocyte differentiation (GO:0048708)3.40455768
38male gamete generation (GO:0048232)3.27849827
39spermatogenesis (GO:0007283)3.27664019
40protein targeting to Golgi (GO:0000042)3.27167616
41presynaptic membrane organization (GO:0097090)3.23629896
42reproduction (GO:0000003)3.22600104
43sexual reproduction (GO:0019953)3.21830168
44establishment of protein localization to Golgi (GO:0072600)3.21372864
45presynaptic membrane assembly (GO:0097105)3.19023324
46pigment granule organization (GO:0048753)3.18477958
47dendritic spine organization (GO:0097061)3.13828559
48myelination (GO:0042552)3.10167425
49cellular ketone body metabolic process (GO:0046950)3.06060417
50coenzyme catabolic process (GO:0009109)3.05984665
51rRNA methylation (GO:0031167)3.05720769
52gamete generation (GO:0007276)3.03027397
53ensheathment of neurons (GO:0007272)3.00494158
54axon ensheathment (GO:0008366)3.00494158
55retrograde transport, vesicle recycling within Golgi (GO:0000301)3.00122286
56actin filament capping (GO:0051693)2.99984988
57musculoskeletal movement (GO:0050881)2.99360445
58multicellular organismal movement (GO:0050879)2.99360445
59spermatid nucleus differentiation (GO:0007289)2.96825970
60proline transport (GO:0015824)2.93659956
61neuroepithelial cell differentiation (GO:0060563)2.91244470
62cell-cell recognition (GO:0009988)2.89878053
63negative regulation of Rho protein signal transduction (GO:0035024)2.89611208
64phosphatidylethanolamine biosynthetic process (GO:0006646)2.89383042
65oligodendrocyte differentiation (GO:0048709)2.89133731
66microtubule nucleation (GO:0007020)2.87919164
67protein depolymerization (GO:0051261)2.86488468
68amino acid import (GO:0043090)2.86346717
69centrosome duplication (GO:0051298)2.85076861
70L-amino acid import (GO:0043092)2.82060079
71astrocyte development (GO:0014002)2.80783643
72alanine transport (GO:0032328)2.78850641
73synaptic vesicle exocytosis (GO:0016079)2.73614535
74sodium ion export (GO:0071436)2.71100134
75positive regulation of Rab GTPase activity (GO:0032851)2.68902768
76regulation of Rab GTPase activity (GO:0032313)2.68902768
77phosphatidylethanolamine metabolic process (GO:0046337)2.67189870
78peptidyl-proline hydroxylation (GO:0019511)2.66504880
79locomotory exploration behavior (GO:0035641)2.65422646
80synaptic vesicle maturation (GO:0016188)2.63106388
81negative regulation of synaptic transmission, GABAergic (GO:0032229)2.61695183
82negative regulation of actin filament depolymerization (GO:0030835)2.60906618
83G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.59920579
84retinal rod cell development (GO:0046548)2.55659764
85cyclic nucleotide catabolic process (GO:0009214)2.54309123
86germ cell development (GO:0007281)2.54164220
87glomerular visceral epithelial cell development (GO:0072015)2.53631101
88long-term synaptic potentiation (GO:0060291)2.51795564
89chromatin silencing (GO:0006342)2.48669295
90membrane assembly (GO:0071709)2.48407664
91pigment biosynthetic process (GO:0046148)2.48044855
92synaptic vesicle docking involved in exocytosis (GO:0016081)2.47794753
93cellular process involved in reproduction in multicellular organism (GO:0022412)2.45244099
94regulation of neuronal synaptic plasticity (GO:0048168)2.44517625
95glutamate secretion (GO:0014047)2.42654121
96glycerol ether metabolic process (GO:0006662)2.41412182
97acidic amino acid transport (GO:0015800)2.40554440
98rRNA modification (GO:0000154)2.39997248
99melanin biosynthetic process (GO:0042438)11.4118318
100melanin metabolic process (GO:0006582)10.3085270

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human2.76369227
2MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.65783902
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.59508192
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.43921790
5DROSHA_22980978_ChIP-Seq_HELA_Human2.35077523
6CTBP2_25329375_ChIP-Seq_LNCAP_Human2.18758042
7GBX2_23144817_ChIP-Seq_PC3_Human2.13857931
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.94279434
9AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.84955347
10ARNT_22903824_ChIP-Seq_MCF-7_Human1.83164509
11P300_19829295_ChIP-Seq_ESCs_Human1.82580595
12* SMAD3_21741376_ChIP-Seq_EPCs_Human1.79438382
13SMAD4_21799915_ChIP-Seq_A2780_Human1.77858188
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.77106312
15AR_21572438_ChIP-Seq_LNCaP_Human1.73802387
16* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.73795461
17CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72398495
18* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.69910343
19FUS_26573619_Chip-Seq_HEK293_Human1.69095064
20* STAT3_23295773_ChIP-Seq_U87_Human1.66789032
21MITF_21258399_ChIP-Seq_MELANOMA_Human1.63879537
22SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.63501583
23SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57371530
24OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57073910
25* CBP_20019798_ChIP-Seq_JUKART_Human1.57068205
26* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.57068205
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.48376229
28SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48233805
29ZNF217_24962896_ChIP-Seq_MCF-7_Human1.47419533
30AR_25329375_ChIP-Seq_VCAP_Human1.46754975
31TCF4_23295773_ChIP-Seq_U87_Human1.46346227
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45995732
33AHR_22903824_ChIP-Seq_MCF-7_Human1.44653639
34TP53_18474530_ChIP-ChIP_U2OS_Human1.44220795
35MTF2_20144788_ChIP-Seq_MESCs_Mouse1.42523384
36REST_21632747_ChIP-Seq_MESCs_Mouse1.42060928
37SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.41574694
38TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40463644
39POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.40463644
40* SMAD3_21741376_ChIP-Seq_ESCs_Human1.39573506
41TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39551498
42* SMAD4_21741376_ChIP-Seq_EPCs_Human1.38492994
43* SMAD4_21741376_ChIP-Seq_HESCs_Human1.38218128
44* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.36650141
45CJUN_26792858_Chip-Seq_BT549_Human1.36567608
46TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.36470034
47NANOG_18555785_Chip-Seq_ESCs_Mouse1.35107313
48TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.34744844
49* SOX2_21211035_ChIP-Seq_LN229_Gbm1.31014485
50EZH2_27294783_Chip-Seq_ESCs_Mouse1.30951958
51SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.28871632
52CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27677612
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.23502386
54SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22350091
55* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21797822
56TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.21793808
57GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.21452983
58SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.18975662
59E2F1_18555785_Chip-Seq_ESCs_Mouse1.17689055
60RARB_27405468_Chip-Seq_BRAIN_Mouse1.17467709
61KDM2B_26808549_Chip-Seq_REH_Human1.16475270
62ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15706294
63TAF15_26573619_Chip-Seq_HEK293_Human1.15217012
64SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.15137360
65SUZ12_27294783_Chip-Seq_ESCs_Mouse1.14626475
66CDX2_19796622_ChIP-Seq_MESCs_Mouse1.14559817
67ER_23166858_ChIP-Seq_MCF-7_Human1.12128717
68NFIB_24661679_ChIP-Seq_LUNG_Mouse1.11547385
69NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.11523762
70* TBL1_22424771_ChIP-Seq_293T_Human1.10620718
71GF1_26923725_Chip-Seq_HPCs_Mouse1.10499072
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09644452
73SMAD_19615063_ChIP-ChIP_OVARY_Human1.08677731
74MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08244127
75KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.07684626
76REST_18959480_ChIP-ChIP_MESCs_Mouse1.07660079
77AUTS2_25519132_ChIP-Seq_293T-REX_Human1.07527223
78JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06524371
79TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06417322
80TP53_23651856_ChIP-Seq_MEFs_Mouse1.05604268
81ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.04402356
82YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03237981
83P53_22387025_ChIP-Seq_ESCs_Mouse1.02749358
84* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01261996
85RUNX2_22187159_ChIP-Seq_PCA_Human1.00979484
86MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00306575
87EZH2_27304074_Chip-Seq_ESCs_Mouse0.99962056
88JARID2_20075857_ChIP-Seq_MESCs_Mouse0.99693203
89PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.99588804
90CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.99420166
91TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98895313
92* AR_19668381_ChIP-Seq_PC3_Human0.98887144
93SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98732050
94RNF2_18974828_ChIP-Seq_MESCs_Mouse0.98283897
95EZH2_18974828_ChIP-Seq_MESCs_Mouse0.98283897
96JARID2_20064375_ChIP-Seq_MESCs_Mouse0.98159625
97P300_18555785_Chip-Seq_ESCs_Mouse0.97094339
98CBX2_22325352_ChIP-Seq_293T-Rex_Human0.96399142
99WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95645981
100ETV2_25802403_ChIP-Seq_MESCs_Mouse0.95605895

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation8.04959609
2MP0000372_irregular_coat_pigmentation6.00730391
3MP0003136_yellow_coat_color5.69634407
4MP0005408_hypopigmentation4.86240053
5MP0000015_abnormal_ear_pigmentation4.13912166
6MP0005410_abnormal_fertilization3.57094555
7MP0000569_abnormal_digit_pigmentation3.30195570
8MP0005075_abnormal_melanosome_morpholog3.22532523
9MP0002095_abnormal_skin_pigmentation3.11084316
10MP0004381_abnormal_hair_follicle2.99278888
11MP0005174_abnormal_tail_pigmentation2.84264212
12MP0000371_diluted_coat_color2.64469193
13MP0003878_abnormal_ear_physiology2.63896957
14MP0005377_hearing/vestibular/ear_phenot2.63896957
15MP0002877_abnormal_melanocyte_morpholog2.60863737
16MP0000920_abnormal_myelination2.21536348
17MP0004859_abnormal_synaptic_plasticity2.01311726
18MP0005257_abnormal_intraocular_pressure1.94331369
19MP0005670_abnormal_white_adipose1.85097042
20MP0001324_abnormal_eye_pigmentation1.81209264
21MP0005248_abnormal_Harderian_gland1.78171447
22MP0001486_abnormal_startle_reflex1.78165610
23MP0002075_abnormal_coat/hair_pigmentati1.70795324
24MP0003690_abnormal_glial_cell1.62184607
25MP0005423_abnormal_somatic_nervous1.61272799
26MP0002938_white_spotting1.57945755
27MP0004885_abnormal_endolymph1.55477555
28MP0004270_analgesia1.55093838
29MP0002272_abnormal_nervous_system1.51387287
30MP0002064_seizures1.43979919
31MP0001186_pigmentation_phenotype1.38206436
32MP0003698_abnormal_male_reproductive1.35991073
33MP0009046_muscle_twitch1.31373259
34MP0001485_abnormal_pinna_reflex1.25209312
35MP0002229_neurodegeneration1.25166169
36MP0008569_lethality_at_weaning1.20782638
37MP0005409_darkened_coat_color1.13057419
38MP0003635_abnormal_synaptic_transmissio1.10645576
39MP0001299_abnormal_eye_distance/1.06697407
40MP0001348_abnormal_lacrimal_gland1.05829370
41MP0003950_abnormal_plasma_membrane1.05094235
42MP0001929_abnormal_gametogenesis1.04505436
43MP0000749_muscle_degeneration0.99985196
44MP0001984_abnormal_olfaction0.98112461
45MP0003634_abnormal_glial_cell0.98048382
46MP0002822_catalepsy0.97737165
47MP0003172_abnormal_lysosome_physiology0.97725353
48MP0009780_abnormal_chondrocyte_physiolo0.97405704
49MP0009745_abnormal_behavioral_response0.96741921
50MP0001968_abnormal_touch/_nociception0.95096169
51MP0003646_muscle_fatigue0.94988026
52MP0003632_abnormal_nervous_system0.92324618
53MP0002090_abnormal_vision0.91106928
54MP0002067_abnormal_sensory_capabilities0.91052918
55MP0002734_abnormal_mechanical_nocicepti0.90350827
56MP0000955_abnormal_spinal_cord0.89309160
57MP0002063_abnormal_learning/memory/cond0.89027154
58MP0002735_abnormal_chemical_nociception0.88156688
59MP0001963_abnormal_hearing_physiology0.88112385
60MP0005551_abnormal_eye_electrophysiolog0.87586080
61MP0001905_abnormal_dopamine_level0.86185372
62MP0002572_abnormal_emotion/affect_behav0.80704976
63MP0005253_abnormal_eye_physiology0.80293322
64MP0003880_abnormal_central_pattern0.76264067
65MP0002638_abnormal_pupillary_reflex0.75827121
66MP0002161_abnormal_fertility/fecundity0.74025575
67MP0003633_abnormal_nervous_system0.73857279
68MP0003631_nervous_system_phenotype0.73832937
69MP0001501_abnormal_sleep_pattern0.73542869
70MP0005197_abnormal_uvea_morphology0.73120223
71MP0004742_abnormal_vestibular_system0.73079534
72MP0001970_abnormal_pain_threshold0.72092710
73MP0003879_abnormal_hair_cell0.71362465
74MP0004510_myositis0.71171281
75MP0005386_behavior/neurological_phenoty0.67727942
76MP0004924_abnormal_behavior0.67727942
77MP0004142_abnormal_muscle_tone0.64737219
78MP0002882_abnormal_neuron_morphology0.62891908
79MP0002102_abnormal_ear_morphology0.60577876
80MP0002066_abnormal_motor_capabilities/c0.58949750
81MP0002557_abnormal_social/conspecific_i0.58687092
82MP0004036_abnormal_muscle_relaxation0.57606916
83MP0002733_abnormal_thermal_nociception0.57027392
84MP0003329_amyloid_beta_deposits0.55862370
85MP0003718_maternal_effect0.53857869
86MP0000026_abnormal_inner_ear0.52925543
87MP0004484_altered_response_of0.52278525
88MP0000778_abnormal_nervous_system0.51127023
89MP0002752_abnormal_somatic_nervous0.49019492
90MP0001440_abnormal_grooming_behavior0.47954715
91MP0006138_congestive_heart_failure0.47820443
92MP0002177_abnormal_outer_ear0.46710236
93MP0003045_fibrosis0.46426381
94MP0004811_abnormal_neuron_physiology0.45692519
95MP0000534_abnormal_ureter_morphology0.42691307
96MP0000747_muscle_weakness0.40741690
97MP0001502_abnormal_circadian_rhythm0.40692854
98MP0002269_muscular_atrophy0.38822982
99MP0000367_abnormal_coat/_hair0.37811563
100MP0000681_abnormal_thyroid_gland0.36670647

Predicted human phenotypes

RankGene SetZ-score
1White forelock (HP:0002211)7.84443939
2Patchy hypopigmentation of hair (HP:0011365)7.25006639
3Hypoplasia of the fovea (HP:0007750)6.68180818
4Aplasia/Hypoplasia of the fovea (HP:0008060)6.68180818
5Ocular albinism (HP:0001107)6.36255011
6Blue irides (HP:0000635)6.34759009
7Aplasia/Hypoplasia of the macula (HP:0008059)6.26194262
8Aplasia/Hypoplasia affecting the retina (HP:0008061)5.83053288
9Abnormality of the fovea (HP:0000493)5.55500683
10Iris hypopigmentation (HP:0007730)5.49257162
11Abnormal auditory evoked potentials (HP:0006958)5.41046150
12Hypoplasia of the iris (HP:0007676)4.70886306
13Peripheral hypomyelination (HP:0007182)4.61153310
14Congenital sensorineural hearing impairment (HP:0008527)4.44522312
15Heterochromia iridis (HP:0001100)4.32381715
16Hypopigmentation of the fundus (HP:0007894)4.18774074
17Severe visual impairment (HP:0001141)4.03104132
18Generalized hypopigmentation (HP:0007513)3.94101889
19Albinism (HP:0001022)3.77020076
20Upper limb muscle weakness (HP:0003484)3.70942986
21Alacrima (HP:0000522)3.66252100
22Action tremor (HP:0002345)3.66009074
23Degeneration of the lateral corticospinal tracts (HP:0002314)3.57457242
24Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.57457242
25Scanning speech (HP:0002168)3.54111440
26Bell-shaped thorax (HP:0001591)3.34934399
27Cerebral hypomyelination (HP:0006808)3.34273514
28Spastic paraparesis (HP:0002313)3.33464631
29Premature graying of hair (HP:0002216)3.22696942
30Abnormality of the corticospinal tract (HP:0002492)3.17867496
31Decreased lacrimation (HP:0000633)3.15635933
32Insidious onset (HP:0003587)2.99592923
33Termporal pattern (HP:0011008)2.99592923
34Decreased motor nerve conduction velocity (HP:0003431)2.66745619
35Cerebral inclusion bodies (HP:0100314)2.53449698
36Focal motor seizures (HP:0011153)2.52946810
37Morphological abnormality of the inner ear (HP:0011390)2.50532706
38Dysmetria (HP:0001310)2.43721796
39Amblyopia (HP:0000646)2.43599353
40Paraparesis (HP:0002385)2.42850106
41Cutaneous melanoma (HP:0012056)2.39358283
42Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.37730674
43Attenuation of retinal blood vessels (HP:0007843)2.32074526
44Myokymia (HP:0002411)2.29345198
45Decreased central vision (HP:0007663)2.28342352
46Resting tremor (HP:0002322)2.24349199
47Freckling (HP:0001480)2.23509096
48Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.23204345
49Hand muscle atrophy (HP:0009130)2.21723860
50Asymmetric septal hypertrophy (HP:0001670)2.21150228
51Bilateral sensorineural hearing impairment (HP:0008619)2.21131396
52Tubulointerstitial nephritis (HP:0001970)2.19678478
53Postural instability (HP:0002172)2.18340811
54Abnormality of the ischium (HP:0003174)2.14597110
55Underdeveloped nasal alae (HP:0000430)2.13686208
56Neurofibrillary tangles (HP:0002185)2.13502624
57Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.12364572
58Hypoplastic ischia (HP:0003175)2.12162478
59Stridor (HP:0010307)2.08384164
60Generalized hypopigmentation of hair (HP:0011358)2.07198005
61Intellectual disability, moderate (HP:0002342)2.00480523
62Horizontal nystagmus (HP:0000666)1.93673123
63Spastic gait (HP:0002064)1.93491194
64Hyperkalemia (HP:0002153)1.89548541
65Supranuclear gaze palsy (HP:0000605)1.89297501
66Megalencephaly (HP:0001355)1.85156865
67Focal seizures (HP:0007359)1.84304098
68Submucous cleft hard palate (HP:0000176)1.82485279
69Abnormality of macular pigmentation (HP:0008002)1.81679989
70Progressive cerebellar ataxia (HP:0002073)1.81314561
71Upper limb amyotrophy (HP:0009129)1.79868888
72Distal upper limb amyotrophy (HP:0007149)1.79868888
73Ulnar claw (HP:0001178)1.79383423
74Bony spicule pigmentary retinopathy (HP:0007737)1.74824813
75Bowel incontinence (HP:0002607)1.73070567
76Onion bulb formation (HP:0003383)1.70991385
77Delusions (HP:0000746)1.67004701
78Recurrent corneal erosions (HP:0000495)1.66908100
79Bradycardia (HP:0001662)1.65239085
80Facial cleft (HP:0002006)1.65114596
81Male infertility (HP:0003251)1.63345118
82CNS hypomyelination (HP:0003429)1.62575116
83Chronic hepatic failure (HP:0100626)1.62560021
84Enlarged epiphyses (HP:0010580)1.62420054
85Synophrys (HP:0000664)1.61326118
86Leukodystrophy (HP:0002415)1.59747765
87Abnormal large intestine physiology (HP:0012700)1.57388401
88Split foot (HP:0001839)1.56894059
89Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.56524142
90Absent epiphyses (HP:0010577)1.56524142
91Difficulty walking (HP:0002355)1.53573137
92Congenital stationary night blindness (HP:0007642)1.49518865
93Distal sensory impairment (HP:0002936)1.49514896
94Intention tremor (HP:0002080)1.48796628
95Abnormality of the epiphysis of the femoral head (HP:0010574)1.47212875
96Sensory axonal neuropathy (HP:0003390)1.45695287
97Akinesia (HP:0002304)1.45133331
98Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.43955928
99Abnormality of femoral epiphyses (HP:0006499)1.43955928
100Abnormality of the costochondral junction (HP:0000919)1.42042521

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.58399564
2TESK13.70385524
3MAP3K93.24244870
4PLK43.20531884
5PLK23.11081311
6MARK12.97327046
7PRKD32.81707266
8TRIM282.57234590
9PDK22.48020792
10UHMK12.26807016
11INSRR2.15129431
12WEE12.05567953
13MARK32.02647073
14FGFR21.97303922
15SIK31.95465168
16PAK61.95170404
17NTRK31.84459871
18PNCK1.72570435
19PBK1.72404510
20STK381.62641158
21MAP4K21.57400849
22MAP3K31.49428157
23NEK61.47274549
24MINK11.46745625
25MET1.43622979
26TYRO31.41545787
27LIMK11.39715111
28LMTK21.34286703
29NTRK21.31146625
30FER1.26699261
31BCR1.25955037
32CAMK1G1.24886459
33WNK11.21774313
34PTK2B1.18803136
35PKN11.15777639
36STK391.12175720
37PRKD11.12102334
38ARAF1.10198382
39MST1R1.07457843
40PAK31.04499383
41LATS21.02894793
42MAPKAPK51.02761354
43TNIK0.99238959
44FRK0.95156714
45PDK10.94586340
46BMPR1B0.92305122
47CSNK1G20.91042309
48PDPK10.90759305
49CDK70.88438265
50CAMK2B0.79464653
51PIK3CG0.77882595
52BRSK10.76962920
53PRKCH0.76292374
54CDK120.72711669
55CSNK1A1L0.72426194
56BRD40.72094368
57MAPK100.71355817
58CAMK2A0.71156212
59PRKCG0.65732520
60STK38L0.65717335
61CSNK1G30.65433231
62DYRK1A0.64193381
63CAMK2D0.64094982
64EPHA40.62780485
65CASK0.62094189
66ROCK20.61089491
67ERBB30.60730595
68KSR20.59708926
69FGFR10.58955318
70CDK50.56203454
71CDK180.55465106
72GSK3A0.55220035
73CDK11A0.55071308
74BRAF0.54188577
75MAP2K10.53839671
76ABL20.53594931
77CSNK1G10.51250903
78NTRK10.50943638
79CAMK2G0.50729705
80GRK50.50464261
81PRKG10.49759805
82CCNB10.49474636
83KSR10.48287425
84CDK30.46775264
85CAMK10.46497317
86ROCK10.46291087
87GSK3B0.42973683
88SGK4940.42456370
89SGK2230.42456370
90CDK140.41010689
91CDK150.40214804
92AKT30.38730979
93RPS6KA30.38154883
94PAK10.37720861
95PRKAA20.36071059
96PTK20.33879326
97PHKG20.33316023
98PHKG10.33316023
99SGK10.32934325
100CSNK1D0.31973065

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000613.24644699
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.09889393
3Nicotine addiction_Homo sapiens_hsa050332.61726118
4Synaptic vesicle cycle_Homo sapiens_hsa047212.55724926
5Histidine metabolism_Homo sapiens_hsa003402.38824012
6Olfactory transduction_Homo sapiens_hsa047402.28599919
7Morphine addiction_Homo sapiens_hsa050322.24254340
8Tyrosine metabolism_Homo sapiens_hsa003502.15017734
9beta-Alanine metabolism_Homo sapiens_hsa004102.13293821
10Glutamatergic synapse_Homo sapiens_hsa047242.04700159
11Melanogenesis_Homo sapiens_hsa049162.02762080
12Taste transduction_Homo sapiens_hsa047422.00451559
13Circadian entrainment_Homo sapiens_hsa047131.91084859
14Long-term potentiation_Homo sapiens_hsa047201.87753387
15GABAergic synapse_Homo sapiens_hsa047271.84839849
16Salivary secretion_Homo sapiens_hsa049701.81052159
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.72524105
18Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.66232507
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.65216164
20Inositol phosphate metabolism_Homo sapiens_hsa005621.63434389
21Calcium signaling pathway_Homo sapiens_hsa040201.63247528
22Arginine and proline metabolism_Homo sapiens_hsa003301.60873150
23Dorso-ventral axis formation_Homo sapiens_hsa043201.54882492
24Phosphatidylinositol signaling system_Homo sapiens_hsa040701.51208587
25Oocyte meiosis_Homo sapiens_hsa041141.48761282
26Insulin secretion_Homo sapiens_hsa049111.48688410
27Gastric acid secretion_Homo sapiens_hsa049711.48134250
28Amphetamine addiction_Homo sapiens_hsa050311.40502750
29Cocaine addiction_Homo sapiens_hsa050301.37288042
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.37071315
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.28653055
32Endocytosis_Homo sapiens_hsa041441.28173336
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.22456675
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16834366
35Renin secretion_Homo sapiens_hsa049241.13153647
36cAMP signaling pathway_Homo sapiens_hsa040241.08953725
37Phospholipase D signaling pathway_Homo sapiens_hsa040721.07252796
38Estrogen signaling pathway_Homo sapiens_hsa049151.02272468
39Vitamin B6 metabolism_Homo sapiens_hsa007501.01454729
40Cholinergic synapse_Homo sapiens_hsa047251.00600311
41ABC transporters_Homo sapiens_hsa020100.97402024
42Sphingolipid metabolism_Homo sapiens_hsa006000.96105293
43Dopaminergic synapse_Homo sapiens_hsa047280.95552793
44Fatty acid metabolism_Homo sapiens_hsa012120.91887275
45Bile secretion_Homo sapiens_hsa049760.90746384
46Adherens junction_Homo sapiens_hsa045200.89234362
47Phototransduction_Homo sapiens_hsa047440.88817239
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87086010
49Vibrio cholerae infection_Homo sapiens_hsa051100.86562019
50Circadian rhythm_Homo sapiens_hsa047100.85753831
51Nitrogen metabolism_Homo sapiens_hsa009100.84059009
52Oxytocin signaling pathway_Homo sapiens_hsa049210.83956883
53Thyroid hormone signaling pathway_Homo sapiens_hsa049190.83867698
54Mineral absorption_Homo sapiens_hsa049780.82408748
55cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82013235
56Gap junction_Homo sapiens_hsa045400.81484468
57Prion diseases_Homo sapiens_hsa050200.80635129
58Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80224464
59Glycosaminoglycan degradation_Homo sapiens_hsa005310.77884164
60Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76724934
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72816870
62Glycerophospholipid metabolism_Homo sapiens_hsa005640.72701933
63Propanoate metabolism_Homo sapiens_hsa006400.70960191
64ECM-receptor interaction_Homo sapiens_hsa045120.70819767
65Pancreatic secretion_Homo sapiens_hsa049720.70502663
66Tight junction_Homo sapiens_hsa045300.69979112
67Glioma_Homo sapiens_hsa052140.69747732
68Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69148297
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.67652463
70Hippo signaling pathway_Homo sapiens_hsa043900.67436960
71Serotonergic synapse_Homo sapiens_hsa047260.67177165
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.66745176
73Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.66369763
74ErbB signaling pathway_Homo sapiens_hsa040120.66251006
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.65629529
76Collecting duct acid secretion_Homo sapiens_hsa049660.65145468
77Butanoate metabolism_Homo sapiens_hsa006500.62948396
78Thyroid hormone synthesis_Homo sapiens_hsa049180.61327338
79Melanoma_Homo sapiens_hsa052180.59820397
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58407268
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57196128
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56221942
83PPAR signaling pathway_Homo sapiens_hsa033200.54090275
84Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52624226
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51416619
86Rap1 signaling pathway_Homo sapiens_hsa040150.49857118
87Ras signaling pathway_Homo sapiens_hsa040140.48630672
88Lysine degradation_Homo sapiens_hsa003100.47186321
89Arginine biosynthesis_Homo sapiens_hsa002200.43436950
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.41005073
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40566305
92MAPK signaling pathway_Homo sapiens_hsa040100.40523852
93Endometrial cancer_Homo sapiens_hsa052130.40496476
94Prostate cancer_Homo sapiens_hsa052150.37448002
95Folate biosynthesis_Homo sapiens_hsa007900.37411773
96Protein digestion and absorption_Homo sapiens_hsa049740.37318498
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35944357
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.35838105
99Axon guidance_Homo sapiens_hsa043600.35386593
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35198502

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