C10ORF76

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)4.01064792
2negative regulation of cell killing (GO:0031342)3.90855447
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.90855447
4positive regulation by symbiont of host defense response (GO:0052509)3.84487538
5modulation by symbiont of host defense response (GO:0052031)3.84487538
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.84487538
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.84487538
8positive regulation by organism of defense response of other organism involved in symbiotic interact3.84487538
9modulation by symbiont of host immune response (GO:0052553)3.84487538
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.81236533
11antigen processing and presentation of endogenous antigen (GO:0019883)3.74804840
12antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.69721190
13macrophage activation involved in immune response (GO:0002281)3.49887850
14negative regulation of erythrocyte differentiation (GO:0045647)3.38151351
15regulation of gamma-delta T cell activation (GO:0046643)3.36904073
16response to peptidoglycan (GO:0032494)3.36588961
17regulation of interferon-beta biosynthetic process (GO:0045357)3.30250260
18immunoglobulin mediated immune response (GO:0016064)3.28420119
19response to muramyl dipeptide (GO:0032495)3.27313151
20detection of other organism (GO:0098543)3.23615599
21negative regulation of interleukin-12 production (GO:0032695)3.17635210
22germinal center formation (GO:0002467)3.12190280
23detection of bacterium (GO:0016045)3.05216155
24stress fiber assembly (GO:0043149)3.00212178
25regulation of B cell receptor signaling pathway (GO:0050855)2.99894554
26neutrophil activation involved in immune response (GO:0002283)2.99408566
27regulation of necroptotic process (GO:0060544)2.95340703
28regulation of gamma-delta T cell differentiation (GO:0045586)2.91164222
29protein localization to endosome (GO:0036010)2.86874399
30regulation of NFAT protein import into nucleus (GO:0051532)2.83830384
31regulation of dendritic cell antigen processing and presentation (GO:0002604)2.81113241
32antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.80134232
33detection of external biotic stimulus (GO:0098581)2.77853324
34pinocytosis (GO:0006907)2.77200008
35lipopolysaccharide-mediated signaling pathway (GO:0031663)2.76932512
36interferon-gamma-mediated signaling pathway (GO:0060333)2.76442672
37detection of molecule of bacterial origin (GO:0032490)2.75959933
38amyloid precursor protein catabolic process (GO:0042987)2.74460980
39positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.73537478
40barbed-end actin filament capping (GO:0051016)2.71953902
41response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.71653586
42response to host immune response (GO:0052572)2.71653586
43cellular response to exogenous dsRNA (GO:0071360)2.70639230
44positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.64620298
45positive regulation of leukocyte degranulation (GO:0043302)2.63639434
46regulation of leukocyte degranulation (GO:0043300)2.61899030
47B cell receptor signaling pathway (GO:0050853)2.60817631
48regulation of antigen processing and presentation (GO:0002577)2.58539907
49response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.58190042
50response to host (GO:0075136)2.58190042
51response to host defenses (GO:0052200)2.58190042
52cellular response to type I interferon (GO:0071357)2.58062220
53type I interferon signaling pathway (GO:0060337)2.58062220
54regulation of type I interferon-mediated signaling pathway (GO:0060338)2.57202886
55negative regulation of necroptotic process (GO:0060546)2.57119939
56positive regulation of antigen processing and presentation (GO:0002579)2.56701020
57negative regulation of T cell mediated immunity (GO:0002710)2.55841686
58response to type I interferon (GO:0034340)2.55098549
59mannose metabolic process (GO:0006013)2.53646299
60T-helper 1 type immune response (GO:0042088)2.53564236
61regulation of mast cell degranulation (GO:0043304)2.53520388
62glycosphingolipid catabolic process (GO:0046479)2.52415126
63negative regulation of interleukin-6 production (GO:0032715)2.51267554
64negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.49910350
65cellular response to thyroid hormone stimulus (GO:0097067)2.49832632
66NIK/NF-kappaB signaling (GO:0038061)2.48281517
67positive regulation of mast cell activation (GO:0033005)2.46338506
68response to laminar fluid shear stress (GO:0034616)2.46063296
69regulation of hypersensitivity (GO:0002883)2.46031265
70cellular extravasation (GO:0045123)2.45483436
71positive regulation of interferon-alpha production (GO:0032727)2.44913129
72macrophage activation (GO:0042116)2.44428406
73myeloid cell activation involved in immune response (GO:0002275)2.42201543
74positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.42161073
75detection of biotic stimulus (GO:0009595)2.41967416
76negative regulation of lymphocyte mediated immunity (GO:0002707)2.41636313
77regulation of myeloid leukocyte mediated immunity (GO:0002886)2.39644499
78regulation of interferon-alpha production (GO:0032647)2.37445895
79microglial cell activation (GO:0001774)2.37322966
80JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.35876050
81positive regulation of mast cell degranulation (GO:0043306)2.32201758
82positive regulation of mast cell activation involved in immune response (GO:0033008)2.32201758
83positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.31741613
84positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.29883387
85regulation of defense response to virus by virus (GO:0050690)2.29706738
86regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.29414836
87regulation of mast cell activation involved in immune response (GO:0033006)2.28417933
88positive regulation of Cdc42 GTPase activity (GO:0043089)2.27344601
89B cell homeostasis (GO:0001782)2.26365500
90positive regulation of B cell differentiation (GO:0045579)2.24577070
91negative regulation of leukocyte mediated immunity (GO:0002704)2.24556189
92regulation of mast cell activation (GO:0033003)2.21619980
93Arp2/3 complex-mediated actin nucleation (GO:0034314)2.20510131
94positive thymic T cell selection (GO:0045059)2.20395105
95T cell selection (GO:0045058)2.19725439
96positive regulation of tumor necrosis factor production (GO:0032760)2.18795599
97positive regulation of Rap GTPase activity (GO:0032854)2.18760514
98glycolipid catabolic process (GO:0019377)2.18426359
99negative regulation of innate immune response (GO:0045824)2.17400243
100positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.17275829

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.56621276
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.05118943
3SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.85143956
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.79943981
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.72283140
6IRF8_27001747_Chip-Seq_BMDM_Mouse2.67639568
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.63883544
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.58934786
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.58199019
10MYC_22102868_ChIP-Seq_BL_Human2.36828769
11VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.32820087
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.32170934
13VDR_21846776_ChIP-Seq_THP-1_Human2.26740726
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.23496201
15KDM2B_26808549_Chip-Seq_SUP-B15_Human2.22952644
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.19924597
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.18330871
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.14399602
19Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.09244008
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.06843548
21VDR_24763502_ChIP-Seq_THP-1_Human2.05137835
22RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.03028650
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.01297667
24TCF7_22412390_ChIP-Seq_EML_Mouse1.97005320
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.90508390
26BRD4_27068464_Chip-Seq_AML-cells_Mouse1.89101185
27RUNX_20019798_ChIP-Seq_JUKART_Human1.87513087
28ELK3_25401928_ChIP-Seq_HUVEC_Human1.84965941
29MAF_26560356_Chip-Seq_TH1_Human1.82946795
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.80178028
31KDM2B_26808549_Chip-Seq_DND41_Human1.79908078
32SPI1_23127762_ChIP-Seq_K562_Human1.79831327
33STAT4_19710469_ChIP-ChIP_TH1__Mouse1.78048138
34SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.77389336
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.76888068
36KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.75699530
37IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.73472886
38RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.68604287
39GATA1_19941827_ChIP-Seq_MEL_Mouse1.65182285
40VDR_24787735_ChIP-Seq_THP-1_Human1.63899752
41FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.63323765
42KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.57980272
43LXR_22292898_ChIP-Seq_THP-1_Human1.57226906
44SCL_19346495_ChIP-Seq_HPC-7_Human1.53439102
45UTX_26944678_Chip-Seq_JUKART_Human1.51548897
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.50097594
47SPI1_23547873_ChIP-Seq_NB4_Human1.50024071
48* MYB_26560356_Chip-Seq_TH2_Human1.48334981
49TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.40698962
50ESR1_20079471_ChIP-ChIP_T-47D_Human1.37786181
51TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.37236284
52RARG_19884340_ChIP-ChIP_MEFs_Mouse1.37108270
53SMAD_19615063_ChIP-ChIP_OVARY_Human1.36700404
54TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.36508468
55RACK7_27058665_Chip-Seq_MCF-7_Human1.34385696
56MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.30879643
57STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.28998678
58TBX20_22080862_ChIP-Seq_HEART_Mouse1.27935772
59TBX20_22328084_ChIP-Seq_HEART_Mouse1.27935772
60* MYB_26560356_Chip-Seq_TH1_Human1.27528359
61TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26658555
62PU_27001747_Chip-Seq_BMDM_Mouse1.26011274
63MAF_26560356_Chip-Seq_TH2_Human1.24382659
64GATA2_21666600_ChIP-Seq_HMVEC_Human1.22606107
65GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21694140
66PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20851041
67CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20740799
68LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.19268398
69KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16926051
70PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.16916267
71SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15657039
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.13886677
73LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10959968
74KDM2B_26808549_Chip-Seq_JURKAT_Human1.10814459
75TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06906741
76NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.06846874
77KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06487870
78KDM2B_26808549_Chip-Seq_K562_Human1.05791271
79GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02822226
80PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02065645
81P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02047374
82CLOCK_20551151_ChIP-Seq_293T_Human1.01918293
83RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01694212
84CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00791094
85GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00133606
86FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.98617715
87PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97841955
88SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.97618551
89SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.97618551
90GATA3_27048872_Chip-Seq_THYMUS_Human0.97581234
91DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96138565
92MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.94888479
93GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94521582
94GATA1_22025678_ChIP-Seq_K562_Human0.94120001
95CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.93531412
96P300_27058665_Chip-Seq_ZR-75-30cells_Human0.92753158
97STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.92583922
98CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.92005455
99ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.91917167
100ESR1_21235772_ChIP-Seq_MCF-7_Human0.91879534

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.38196366
2MP0003436_decreased_susceptibility_to2.98870474
3MP0005451_abnormal_body_composition2.88067538
4MP0003303_peritoneal_inflammation2.82776038
5MP0005058_abnormal_lysosome_morphology2.67464941
6MP0009840_abnormal_foam_cell2.53560532
7MP0000685_abnormal_immune_system2.46661196
8MP0003724_increased_susceptibility_to2.25981356
9MP0003300_gastrointestinal_ulcer2.25148820
10MP0003191_abnormal_cellular_cholesterol2.21574821
11MP0002419_abnormal_innate_immunity2.18739159
12MP0005000_abnormal_immune_tolerance2.16665349
13MP0001800_abnormal_humoral_immune2.14540793
14MP0009785_altered_susceptibility_to2.12726366
15MP0005387_immune_system_phenotype2.12265912
16MP0001790_abnormal_immune_system2.12265912
17MP0003183_abnormal_peptide_metabolism2.10342636
18MP0005025_abnormal_response_to2.09786920
19MP0005671_abnormal_response_to2.08564717
20MP0004510_myositis2.07279806
21MP0002148_abnormal_hypersensitivity_rea2.01703906
22MP0008260_abnormal_autophagy2.00919986
23MP0006082_CNS_inflammation1.99323292
24MP0003763_abnormal_thymus_physiology1.95884250
25MP0002452_abnormal_antigen_presenting1.94237559
26MP0003172_abnormal_lysosome_physiology1.92824745
27MP0002723_abnormal_immune_serum1.90769466
28MP0004233_abnormal_muscle_weight1.80245573
29MP0003828_pulmonary_edema1.80149512
30MP0002420_abnormal_adaptive_immunity1.73389665
31MP0004947_skin_inflammation1.72607130
32MP0001819_abnormal_immune_cell1.71630584
33MP0000604_amyloidosis1.67912447
34MP0003646_muscle_fatigue1.64759518
35MP0001533_abnormal_skeleton_physiology1.58703851
36MP0002998_abnormal_bone_remodeling1.54439565
37MP0002405_respiratory_system_inflammati1.52548636
38MP0010155_abnormal_intestine_physiology1.51363001
39MP0005409_darkened_coat_color1.51314807
40MP0005464_abnormal_platelet_physiology1.48377426
41MP0002254_reproductive_system_inflammat1.47424858
42MP0003329_amyloid_beta_deposits1.46610498
43MP0002332_abnormal_exercise_endurance1.41334934
44MP0004130_abnormal_muscle_cell1.40524165
45MP0003091_abnormal_cell_migration1.34148369
46MP0009278_abnormal_bone_marrow1.33948097
47MP0001845_abnormal_inflammatory_respons1.32184891
48MP0000716_abnormal_immune_system1.31102736
49MP0002166_altered_tumor_susceptibility1.29328064
50MP0000751_myopathy1.26326455
51MP0002398_abnormal_bone_marrow1.23038396
52MP0005310_abnormal_salivary_gland1.21005271
53MP0008469_abnormal_protein_level1.19732849
54MP0001851_eye_inflammation1.16691112
55MP0004036_abnormal_muscle_relaxation1.13570954
56MP0009764_decreased_sensitivity_to1.12412514
57MP0003705_abnormal_hypodermis_morpholog1.11670272
58MP0003075_altered_response_to1.10562018
59MP0004808_abnormal_hematopoietic_stem1.07622922
60MP0003656_abnormal_erythrocyte_physiolo1.07547674
61MP0002009_preneoplasia1.05703739
62MP0000858_altered_metastatic_potential1.05110203
63MP0000343_altered_response_to1.02237521
64MP0002429_abnormal_blood_cell1.00553366
65MP0000689_abnormal_spleen_morphology1.00147691
66MP0009115_abnormal_fat_cell0.99114940
67MP0005670_abnormal_white_adipose0.98988035
68MP0002877_abnormal_melanocyte_morpholog0.98439631
69MP0003566_abnormal_cell_adhesion0.95771850
70MP0000747_muscle_weakness0.94308098
71MP0003045_fibrosis0.93196094
72MP0000249_abnormal_blood_vessel0.93074919
73MP0009333_abnormal_splenocyte_physiolog0.91899030
74MP0003221_abnormal_cardiomyocyte_apopto0.91561220
75MP0001545_abnormal_hematopoietic_system0.90326142
76MP0005397_hematopoietic_system_phenotyp0.90326142
77MP0004484_altered_response_of0.90320088
78MP0001958_emphysema0.89346794
79MP0003950_abnormal_plasma_membrane0.89301013
80MP0003866_abnormal_defecation0.88436911
81MP0004087_abnormal_muscle_fiber0.88351982
82MP0002722_abnormal_immune_system0.88284231
83MP0000465_gastrointestinal_hemorrhage0.86558029
84MP0001853_heart_inflammation0.86492806
85MP0003453_abnormal_keratinocyte_physiol0.85615605
86MP0008874_decreased_physiological_sensi0.85449015
87MP0004883_abnormal_blood_vessel0.84930508
88MP0004084_abnormal_cardiac_muscle0.83932184
89MP0002269_muscular_atrophy0.83513755
90MP0000759_abnormal_skeletal_muscle0.83458989
91MP0002933_joint_inflammation0.81755564
92MP0005165_increased_susceptibility_to0.81317811
93MP0005375_adipose_tissue_phenotype0.80456975
94MP0005076_abnormal_cell_differentiation0.80086501
95MP0001542_abnormal_bone_strength0.79119693
96MP0001873_stomach_inflammation0.78335676
97MP0005666_abnormal_adipose_tissue0.77946812
98MP0005330_cardiomyopathy0.76021815
99MP0005167_abnormal_blood-brain_barrier0.75845693
100MP0006138_congestive_heart_failure0.75336941

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycosphingolipid metabolism (HP:0004343)4.06869620
2Abnormality of glycolipid metabolism (HP:0010969)4.06869620
3Abnormality of liposaccharide metabolism (HP:0010968)4.06869620
4Recurrent abscess formation (HP:0002722)3.72619765
5Recurrent bacterial skin infections (HP:0005406)3.64432425
6Eczematoid dermatitis (HP:0000976)3.55939690
7Asymmetric septal hypertrophy (HP:0001670)3.34820220
8Elevated erythrocyte sedimentation rate (HP:0003565)3.28018063
9Abnormality of macrophages (HP:0004311)3.13377747
10Increased cerebral lipofuscin (HP:0011813)3.09288838
11Distal lower limb muscle weakness (HP:0009053)3.07371293
12Centrally nucleated skeletal muscle fibers (HP:0003687)2.93573972
13Gingivitis (HP:0000230)2.74528825
14Recurrent cutaneous fungal infections (HP:0011370)2.71363633
15Chronic mucocutaneous candidiasis (HP:0002728)2.71363633
16Amyloidosis (HP:0011034)2.69228913
17Distal lower limb amyotrophy (HP:0008944)2.68342673
18Stomatitis (HP:0010280)2.67560513
19Systemic lupus erythematosus (HP:0002725)2.65519230
20Recurrent fungal infections (HP:0002841)2.61862090
21Recurrent skin infections (HP:0001581)2.57715982
22Increased neuronal autofluorescent lipopigment (HP:0002074)2.55278005
23Spontaneous hematomas (HP:0007420)2.54031281
24Colitis (HP:0002583)2.53892974
25Fatigue (HP:0012378)2.53120159
26Dysostosis multiplex (HP:0000943)2.51427617
27Ragged-red muscle fibers (HP:0003200)2.45916857
28Exercise-induced myalgia (HP:0003738)2.45576031
29Myositis (HP:0100614)2.43269102
30Gastrointestinal stroma tumor (HP:0100723)2.39211559
31Mediastinal lymphadenopathy (HP:0100721)2.34974959
32Loss of speech (HP:0002371)2.34464509
33Recurrent viral infections (HP:0004429)2.32948918
34Increased IgE level (HP:0003212)2.30926246
35Bundle branch block (HP:0011710)2.29947623
36Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.28104619
37Peritonitis (HP:0002586)2.17925900
38Chest pain (HP:0100749)2.17635399
39Cellulitis (HP:0100658)2.17341353
40Vasculitis (HP:0002633)2.17165892
41Pustule (HP:0200039)2.16606948
42Increased connective tissue (HP:0009025)2.15793616
43Urticaria (HP:0001025)2.15501559
44Hyporeflexia of lower limbs (HP:0002600)2.14165072
45Ventricular tachycardia (HP:0004756)2.14022472
46Orchitis (HP:0100796)2.13578342
47Inflammation of the large intestine (HP:0002037)2.12649709
48Type 1 muscle fiber predominance (HP:0003803)2.12011178
49Recurrent gram-negative bacterial infections (HP:0005420)2.09950839
50Muscle fiber splitting (HP:0003555)2.08805558
51Gastrointestinal inflammation (HP:0004386)2.04640165
52Rhabdomyolysis (HP:0003201)2.03699094
53EMG: myopathic abnormalities (HP:0003458)2.03111685
54Interstitial pulmonary disease (HP:0006530)2.00986766
55Muscle fiber inclusion bodies (HP:0100299)1.97927181
56Abnormality of mucopolysaccharide metabolism (HP:0011020)1.97384206
57Abnormality of polysaccharide metabolism (HP:0011012)1.97384206
58Abnormality of glycosaminoglycan metabolism (HP:0004371)1.97384206
59Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.96410696
60T lymphocytopenia (HP:0005403)1.95406439
61Sudden death (HP:0001699)1.93265043
62Nemaline bodies (HP:0003798)1.91976187
63Abnormality of skeletal muscle fiber size (HP:0012084)1.91703214
64Thin bony cortex (HP:0002753)1.91316420
65Mucopolysacchariduria (HP:0008155)1.91031853
66Urinary glycosaminoglycan excretion (HP:0003541)1.91031853
67Vacuolated lymphocytes (HP:0001922)1.89378673
68Gastrointestinal infarctions (HP:0005244)1.88418998
69Autoimmune thrombocytopenia (HP:0001973)1.88328126
70Frequent falls (HP:0002359)1.87313394
71Neurofibrillary tangles (HP:0002185)1.86063923
72Bilateral sensorineural hearing impairment (HP:0008619)1.85150107
73Upper motor neuron abnormality (HP:0002127)1.84999189
74Myoglobinuria (HP:0002913)1.82987036
75Difficulty running (HP:0009046)1.80941652
76Hypergammaglobulinemia (HP:0010702)1.80940512
77Cerebral inclusion bodies (HP:0100314)1.76923807
78Meningitis (HP:0001287)1.76541419
79Diminished motivation (HP:0000745)1.75895141
80Increased variability in muscle fiber diameter (HP:0003557)1.75238226
81Emphysema (HP:0002097)1.75055509
82Disinhibition (HP:0000734)1.74412949
83Segmental peripheral demyelination/remyelination (HP:0003481)1.74370521
84Malnutrition (HP:0004395)1.74320878
85Restrictive lung disease (HP:0002091)1.73882048
86Optic neuritis (HP:0100653)1.71801022
87Retrobulbar optic neuritis (HP:0100654)1.71801022
88Purpura (HP:0000979)1.70833032
89Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.70663621
90Leukocytosis (HP:0001974)1.69112275
91Apathy (HP:0000741)1.68726526
92Right ventricular cardiomyopathy (HP:0011663)1.68676077
93Myocardial infarction (HP:0001658)1.68589919
94Axonal loss (HP:0003447)1.68477458
95Hematochezia (HP:0002573)1.68086348
96Increased serum ferritin (HP:0003281)1.67594395
97Progressive muscle weakness (HP:0003323)1.67309460
98Pulmonary infiltrates (HP:0002113)1.66994971
99Abnormality of the peritoneum (HP:0002585)1.66390970
100Abnormality of T cell number (HP:0011839)1.66364689

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN12.72297394
2PRPF4B2.70635956
3MAP3K142.53381482
4TRIB32.50978685
5RIPK42.50488112
6TTN2.35112309
7MAP4K12.30430737
8TYK22.21068567
9MAP3K132.03927144
10MAP2K32.03289973
11CSF1R1.98074236
12RIPK11.94469139
13TBK11.79716591
14EPHB11.77990420
15CDK121.71339653
16IRAK41.61449651
17ICK1.61023541
18BLK1.56429716
19NEK91.52247930
20ZAP701.50661322
21IKBKE1.41061205
22CSK1.40803564
23TAOK11.39604403
24KIT1.38891720
25JAK11.33440276
26JAK31.32295192
27MAP3K11.31706228
28MAP3K31.29604784
29MAPK71.27799155
30KSR21.25895715
31PRKD21.25403503
32MAP3K111.24041698
33CDC42BPA1.23307261
34SIK11.22315873
35IRAK31.16575928
36BRD41.10601784
37FES1.10417139
38IKBKB1.10066711
39OBSCN1.08810159
40MARK21.06674831
41CAMK1D1.03049905
42CAMK1G1.02565268
43FGR0.99702963
44TAOK20.98712191
45BTK0.98152705
46FGFR40.96418787
47SYK0.96357187
48MATK0.95164866
49TGFBR20.94164437
50SMG10.92661076
51HCK0.90908344
52MAP3K60.89532081
53SGK30.89222467
54PKN20.83953489
55MAPK120.83664228
56GRK70.83196980
57MOS0.79784889
58GRK60.78764911
59MYLK0.77417100
60JAK20.76142709
61PTK60.76076598
62TNK20.74886461
63CHUK0.74094014
64RPS6KA20.73688031
65PDGFRB0.73644961
66LYN0.73588629
67RPS6KL10.70190441
68RPS6KC10.70190441
69PDK10.69879356
70BMPR20.69685787
71PDPK10.69034637
72MAPK110.68702454
73HIPK20.68397178
74MAP3K50.66934433
75MAP3K70.65968541
76PDGFRA0.65745607
77SIK30.65534377
78LCK0.63065995
79TRPM70.60279887
80STK380.60042667
81DYRK1B0.59936798
82MAP2K20.59513102
83IRAK10.59376964
84MAP3K20.58554270
85ITK0.58321198
86STK100.57735991
87PTK2B0.57604197
88ARAF0.57298094
89CAMK40.57124302
90RPS6KA60.56340771
91CDK60.53981994
92PRKAA20.51614162
93PRKD10.51551893
94MTOR0.48801674
95RET0.47077802
96TEC0.46222271
97CAMKK10.45590199
98FLT30.45512443
99DDR20.44604439
100MAP2K10.44037238

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.34383354
2Leishmaniasis_Homo sapiens_hsa051402.26872494
3Osteoclast differentiation_Homo sapiens_hsa043802.21078226
4B cell receptor signaling pathway_Homo sapiens_hsa046622.10461097
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.99916141
6Staphylococcus aureus infection_Homo sapiens_hsa051501.99787256
7Asthma_Homo sapiens_hsa053101.93253875
8Allograft rejection_Homo sapiens_hsa053301.91499281
9Toll-like receptor signaling pathway_Homo sapiens_hsa046201.82011483
10Viral myocarditis_Homo sapiens_hsa054161.79471454
11Tuberculosis_Homo sapiens_hsa051521.72496563
12Graft-versus-host disease_Homo sapiens_hsa053321.72459563
13Intestinal immune network for IgA production_Homo sapiens_hsa046721.69619933
14Autoimmune thyroid disease_Homo sapiens_hsa053201.68216137
15Toxoplasmosis_Homo sapiens_hsa051451.63373825
16Lysosome_Homo sapiens_hsa041421.57619578
17Influenza A_Homo sapiens_hsa051641.55094445
18Acute myeloid leukemia_Homo sapiens_hsa052211.53300305
19Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.45379321
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.43963108
21Antigen processing and presentation_Homo sapiens_hsa046121.41227241
22Primary immunodeficiency_Homo sapiens_hsa053401.40470113
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.38200165
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.36244747
25TNF signaling pathway_Homo sapiens_hsa046681.36233824
26Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.35698400
27Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.35695938
28T cell receptor signaling pathway_Homo sapiens_hsa046601.29543820
29Type I diabetes mellitus_Homo sapiens_hsa049401.28512163
30Measles_Homo sapiens_hsa051621.22936839
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.21202080
32Hepatitis C_Homo sapiens_hsa051601.21036171
33Neurotrophin signaling pathway_Homo sapiens_hsa047221.15503951
34Rheumatoid arthritis_Homo sapiens_hsa053231.14967639
35Hematopoietic cell lineage_Homo sapiens_hsa046401.14934671
36Glycosaminoglycan degradation_Homo sapiens_hsa005311.12673313
37Pertussis_Homo sapiens_hsa051331.11538384
38Non-small cell lung cancer_Homo sapiens_hsa052231.10693134
39Phagosome_Homo sapiens_hsa041451.09982899
40Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.08950982
41Hepatitis B_Homo sapiens_hsa051611.08709258
42Prolactin signaling pathway_Homo sapiens_hsa049171.08582879
43Malaria_Homo sapiens_hsa051441.07911269
44VEGF signaling pathway_Homo sapiens_hsa043701.07308242
45Chronic myeloid leukemia_Homo sapiens_hsa052201.05296343
46Notch signaling pathway_Homo sapiens_hsa043301.05109921
47Chemokine signaling pathway_Homo sapiens_hsa040621.05021326
48Herpes simplex infection_Homo sapiens_hsa051681.04016023
49Shigellosis_Homo sapiens_hsa051311.03937763
50Salmonella infection_Homo sapiens_hsa051321.03024769
51Legionellosis_Homo sapiens_hsa051341.02253532
52Jak-STAT signaling pathway_Homo sapiens_hsa046301.01036144
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.99965943
54Platelet activation_Homo sapiens_hsa046110.98967078
55Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.96110883
56Adipocytokine signaling pathway_Homo sapiens_hsa049200.96038769
57Pancreatic cancer_Homo sapiens_hsa052120.96010896
58GnRH signaling pathway_Homo sapiens_hsa049120.94579720
59Apoptosis_Homo sapiens_hsa042100.93255398
60Insulin resistance_Homo sapiens_hsa049310.91971507
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.90454493
62Renal cell carcinoma_Homo sapiens_hsa052110.90334580
63Amoebiasis_Homo sapiens_hsa051460.84779586
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78917727
65Bladder cancer_Homo sapiens_hsa052190.78561557
66Endometrial cancer_Homo sapiens_hsa052130.77181604
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73910498
68Endocytosis_Homo sapiens_hsa041440.73879086
69Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73393545
70Prion diseases_Homo sapiens_hsa050200.72984639
71Insulin signaling pathway_Homo sapiens_hsa049100.72555817
72Inositol phosphate metabolism_Homo sapiens_hsa005620.72065580
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.71808075
74mTOR signaling pathway_Homo sapiens_hsa041500.71097583
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.68692002
76Dilated cardiomyopathy_Homo sapiens_hsa054140.68077473
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64922700
78Type II diabetes mellitus_Homo sapiens_hsa049300.64113056
79Estrogen signaling pathway_Homo sapiens_hsa049150.61037553
80Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59989333
81African trypanosomiasis_Homo sapiens_hsa051430.57140290
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56269795
83FoxO signaling pathway_Homo sapiens_hsa040680.55219523
84ErbB signaling pathway_Homo sapiens_hsa040120.55215044
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54610248
86MAPK signaling pathway_Homo sapiens_hsa040100.53416230
87Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52569878
88Dorso-ventral axis formation_Homo sapiens_hsa043200.52391428
89Glioma_Homo sapiens_hsa052140.51484742
90Viral carcinogenesis_Homo sapiens_hsa052030.50574748
91Choline metabolism in cancer_Homo sapiens_hsa052310.50357526
92Focal adhesion_Homo sapiens_hsa045100.49283143
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49160668
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.48238223
95Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.48201469
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47684081
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47663952
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47493523
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47186740
100Prostate cancer_Homo sapiens_hsa052150.46910387

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