C10ORF71

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1skeletal muscle contraction (GO:0003009)9.67998763
2regulation of skeletal muscle contraction (GO:0014819)9.42627625
3regulation of relaxation of muscle (GO:1901077)8.38609678
4myofibril assembly (GO:0030239)7.79663256
5striated muscle contraction (GO:0006941)7.65778812
6actin filament-based movement (GO:0030048)7.64265308
7sarcomere organization (GO:0045214)7.62810358
8positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)7.41235656
9creatine metabolic process (GO:0006600)7.11872882
10response to stimulus involved in regulation of muscle adaptation (GO:0014874)6.98695642
11regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.91337013
12response to muscle activity (GO:0014850)6.78111986
13cardiac myofibril assembly (GO:0055003)6.37713055
14response to inactivity (GO:0014854)6.30463724
15skeletal muscle fiber development (GO:0048741)6.13653339
16cardiac muscle contraction (GO:0060048)6.11498105
17muscle contraction (GO:0006936)5.77389729
18skeletal muscle adaptation (GO:0043501)5.69795919
19regulation of actin filament-based movement (GO:1903115)5.64576468
20actomyosin structure organization (GO:0031032)5.64277653
21myotube cell development (GO:0014904)5.62683701
22regulation of cell communication by electrical coupling (GO:0010649)5.51846454
23regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.47789036
24negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.32864839
25glycogen catabolic process (GO:0005980)5.27538804
26cardiac muscle hypertrophy (GO:0003300)5.22106953
27plasma membrane repair (GO:0001778)5.19699888
28NADH metabolic process (GO:0006734)5.18823683
29muscle system process (GO:0003012)5.16467169
30striated muscle hypertrophy (GO:0014897)4.97472517
31glucan catabolic process (GO:0009251)4.95764552
32muscle fiber development (GO:0048747)4.85339400
33negative regulation of potassium ion transmembrane transport (GO:1901380)4.77244352
34glycogen biosynthetic process (GO:0005978)4.75161103
35glucan biosynthetic process (GO:0009250)4.75161103
36cellular polysaccharide catabolic process (GO:0044247)4.65141082
37skeletal muscle tissue development (GO:0007519)4.61340787
38striated muscle adaptation (GO:0014888)4.58960176
39regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.49214913
40muscle hypertrophy (GO:0014896)4.44148374
41muscle tissue morphogenesis (GO:0060415)4.40693162
42adult heart development (GO:0007512)4.33985005
43regulation of striated muscle contraction (GO:0006942)4.33792753
44cardiac muscle tissue morphogenesis (GO:0055008)4.33507274
45regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.31399545
46regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.24612910
47polysaccharide catabolic process (GO:0000272)4.18757636
482-oxoglutarate metabolic process (GO:0006103)4.17162312
49skeletal muscle tissue regeneration (GO:0043403)4.16912293
50muscle cell cellular homeostasis (GO:0046716)4.15587952
51carnitine shuttle (GO:0006853)4.10341323
52positive regulation of calcium ion transmembrane transporter activity (GO:1901021)4.09166052
53cardiac muscle cell development (GO:0055013)4.06921722
54regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.98463990
55striated muscle cell development (GO:0055002)3.96962963
56tricarboxylic acid cycle (GO:0006099)3.91816299
57regulation of the force of heart contraction (GO:0002026)3.91586193
58regulation of calcium ion transmembrane transport (GO:1903169)3.84969894
59regulation of calcium ion transmembrane transporter activity (GO:1901019)3.84969894
60glycogen metabolic process (GO:0005977)3.82863119
61muscle structure development (GO:0061061)3.77292115
62cardiac cell development (GO:0055006)3.77235069
63muscle organ development (GO:0007517)3.76272218
64fructose metabolic process (GO:0006000)3.76207554
65cellular glucan metabolic process (GO:0006073)3.75212534
66glucan metabolic process (GO:0044042)3.75212534
67cardiac muscle adaptation (GO:0014887)3.72739144
68cardiac muscle hypertrophy in response to stress (GO:0014898)3.72739144
69muscle hypertrophy in response to stress (GO:0003299)3.72739144
70positive regulation of myotube differentiation (GO:0010831)3.72025321
71striated muscle atrophy (GO:0014891)3.71932810
72muscle cell fate commitment (GO:0042693)3.71069430
73muscle adaptation (GO:0043500)3.70392736
74muscle organ morphogenesis (GO:0048644)3.68403377
75gluconeogenesis (GO:0006094)3.67539308
76negative regulation of calcium ion transmembrane transport (GO:1903170)3.65064615
77negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.65064615
78response to activity (GO:0014823)3.64773949
79heart process (GO:0003015)3.64761834
80heart contraction (GO:0060047)3.64761834
81fatty acid transmembrane transport (GO:1902001)3.47865840
82regulation of membrane repolarization (GO:0060306)3.45106132
83regulation of sequestering of triglyceride (GO:0010889)3.40966286
84muscle cell development (GO:0055001)3.40564729
85positive regulation of cation channel activity (GO:2001259)3.39359507
86muscle atrophy (GO:0014889)3.35107191
87relaxation of muscle (GO:0090075)3.34930978
88negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.32515766
89myoblast fusion (GO:0007520)3.31921432
90regulation of muscle system process (GO:0090257)3.29492561
91hexose biosynthetic process (GO:0019319)3.26905211
92striated muscle tissue development (GO:0014706)3.26597333
93membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.25553743
94regulation of myoblast differentiation (GO:0045661)3.25066410
95positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.20586977
96regulation of muscle contraction (GO:0006937)3.19389642
97muscle filament sliding (GO:0030049)12.5581297
98actin-myosin filament sliding (GO:0033275)12.5581297
99sarcoplasmic reticulum calcium ion transport (GO:0070296)11.1518061
100actin-mediated cell contraction (GO:0070252)10.3245347

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.67453141
2EZH2_22144423_ChIP-Seq_EOC_Human5.24924890
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.31880688
4RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.09421458
5PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.50091641
6TBX20_22328084_ChIP-Seq_HEART_Mouse3.15732431
7TBX20_22080862_ChIP-Seq_HEART_Mouse3.15732431
8EP300_21415370_ChIP-Seq_HL-1_Mouse2.91559939
9ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.86240522
10ESR1_20079471_ChIP-ChIP_T-47D_Human2.84915686
11CDX2_19796622_ChIP-Seq_MESCs_Mouse2.79130000
12CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.62197496
13MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.50577204
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.41677318
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.34049794
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.32603854
17PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse2.21041785
18BCL3_23251550_ChIP-Seq_MUSCLE_Mouse2.10349965
19GATA4_21415370_ChIP-Seq_HL-1_Mouse1.90876403
20NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.78021066
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.68470554
22ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.55453862
23RBPJ_22232070_ChIP-Seq_NCS_Mouse1.44704822
24NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.39994546
25ESR2_21235772_ChIP-Seq_MCF-7_Human1.39442226
26NFIB_24661679_ChIP-Seq_LUNG_Mouse1.37986795
27* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.36964830
28CTCF_27219007_Chip-Seq_Bcells_Human1.33489563
29ZNF263_19887448_ChIP-Seq_K562_Human1.33226987
30DROSHA_22980978_ChIP-Seq_HELA_Human1.29649178
31BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.28102388
32IGF1R_20145208_ChIP-Seq_DFB_Human1.26750027
33RARG_19884340_ChIP-ChIP_MEFs_Mouse1.26454410
34TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22592336
35LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.20992183
36EZH2_27294783_Chip-Seq_ESCs_Mouse1.13822634
37CBX2_27304074_Chip-Seq_ESCs_Mouse1.11388922
38RARB_27405468_Chip-Seq_BRAIN_Mouse1.11335795
39GBX2_23144817_ChIP-Seq_PC3_Human1.10886555
40STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.07540061
41FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.07209050
42SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05731062
43SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05563183
44ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.04261293
45CRX_20693478_ChIP-Seq_RETINA_Mouse1.03790752
46SMC3_22415368_ChIP-Seq_MEFs_Mouse1.02964911
47ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.02627401
48SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02342385
49OCT4_20526341_ChIP-Seq_ESCs_Human1.01918845
50EZH2_27294783_Chip-Seq_NPCs_Mouse1.00926725
51GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.00051735
52PPARA_22158963_ChIP-Seq_LIVER_Mouse0.97467388
53E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.96568519
54PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96026638
55OCT4_21477851_ChIP-Seq_ESCs_Mouse0.93714106
56MYC_27129775_Chip-Seq_CORNEA_Mouse0.93656978
57* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.92238567
58CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.92101298
59CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.91993332
60RXR_22158963_ChIP-Seq_LIVER_Mouse0.91640970
61LXR_22158963_ChIP-Seq_LIVER_Mouse0.91321050
62SPI1_20517297_ChIP-Seq_HL60_Human0.91065096
63EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.91031641
64NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.90268486
65SOX2_21211035_ChIP-Seq_LN229_Gbm0.90202559
66GATA1_19941827_ChIP-Seq_MEL_Mouse0.89914166
67VDR_22108803_ChIP-Seq_LS180_Human0.89570097
68CTCF_21964334_ChIP-Seq_BJAB-B_Human0.89128700
69P53_22127205_ChIP-Seq_FIBROBLAST_Human0.85678976
70NRF2_20460467_ChIP-Seq_MEFs_Mouse0.83752020
71NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.83752020
72HTT_18923047_ChIP-ChIP_STHdh_Human0.83138078
73FLI1_27457419_Chip-Seq_LIVER_Mouse0.82867940
74PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.82857264
75SMAD3_21741376_ChIP-Seq_HESCs_Human0.80953131
76MTF2_20144788_ChIP-Seq_MESCs_Mouse0.78717008
77CLOCK_20551151_ChIP-Seq_293T_Human0.78704454
78SA1_27219007_Chip-Seq_Bcells_Human0.78660023
79TRIM28_21343339_ChIP-Seq_HEK293_Human0.76982672
80ER_23166858_ChIP-Seq_MCF-7_Human0.76844592
81KLF5_20875108_ChIP-Seq_MESCs_Mouse0.76007935
82GATA6_21074721_ChIP-Seq_CACO-2_Human0.75840409
83GATA1_19941827_ChIP-Seq_MEL86_Mouse0.72414283
84NR3C1_23031785_ChIP-Seq_PC12_Mouse0.72023720
85STAT1_20625510_ChIP-Seq_HELA_Human0.71526569
86EZH2_27304074_Chip-Seq_ESCs_Mouse0.69524866
87LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.69512854
88SOX2_19829295_ChIP-Seq_ESCs_Human0.69494430
89NANOG_19829295_ChIP-Seq_ESCs_Human0.69494430
90* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.69273453
91RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.68980167
92PHF8_20622853_ChIP-Seq_HELA_Human0.68918624
93STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.68903320
94CTCF_21964334_Chip-Seq_Bcells_Human0.68416476
95GF1_26923725_Chip-Seq_HPCs_Mouse0.68069238
96SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.67951637
97DNAJC2_21179169_ChIP-ChIP_NT2_Human0.67457306
98RAD21_21589869_ChIP-Seq_MESCs_Mouse0.67066183
99EGR1_19032775_ChIP-ChIP_M12_Human0.65976405
100DPY_21335234_ChIP-Seq_ESCs_Mouse0.65686902

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue6.96705109
2MP0004145_abnormal_muscle_electrophysio6.55475699
3MP0000751_myopathy6.17696716
4MP0000749_muscle_degeneration5.69398377
5MP0004036_abnormal_muscle_relaxation4.49450859
6MP0002106_abnormal_muscle_physiology3.71259205
7MP0004084_abnormal_cardiac_muscle3.61252962
8MP0004087_abnormal_muscle_fiber3.49987915
9MP0000747_muscle_weakness3.46145223
10MP0000759_abnormal_skeletal_muscle3.34638187
11MP0005451_abnormal_body_composition3.15489966
12MP0005369_muscle_phenotype3.13324724
13MP0002269_muscular_atrophy3.01980473
14MP0002332_abnormal_exercise_endurance3.00719106
15MP0004130_abnormal_muscle_cell2.96152507
16MP0005330_cardiomyopathy2.90779750
17MP0005620_abnormal_muscle_contractility2.90547068
18MP0000750_abnormal_muscle_regeneration2.87444930
19MP0004233_abnormal_muscle_weight2.85804338
20MP0002837_dystrophic_cardiac_calcinosis2.62793626
21MP0002972_abnormal_cardiac_muscle2.35552760
22MP0004215_abnormal_myocardial_fiber2.28420647
23MP0000733_abnormal_muscle_development2.01220869
24MP0004484_altered_response_of1.98235330
25MP0006036_abnormal_mitochondrial_physio1.91106598
26MP0002108_abnormal_muscle_morphology1.90096968
27MP0004510_myositis1.80844019
28MP0010630_abnormal_cardiac_muscle1.74341377
29MP0006138_congestive_heart_failure1.63370376
30MP0002127_abnormal_cardiovascular_syste1.59991246
31MP0001544_abnormal_cardiovascular_syste1.59806792
32MP0005385_cardiovascular_system_phenoty1.59806792
33MP0000013_abnormal_adipose_tissue1.52768504
34MP0005266_abnormal_metabolism1.40269557
35MP0004270_analgesia1.37322955
36MP0003221_abnormal_cardiomyocyte_apopto1.30132284
37MP0008775_abnormal_heart_ventricle1.22430916
38MP0003137_abnormal_impulse_conducting1.21907209
39MP0005670_abnormal_white_adipose1.16533814
40MP0001661_extended_life_span1.10384366
41MP0002971_abnormal_brown_adipose1.09704655
42MP0003950_abnormal_plasma_membrane1.05051199
43MP0004185_abnormal_adipocyte_glucose0.96309909
44MP0005666_abnormal_adipose_tissue0.94313205
45MP0004085_abnormal_heartbeat0.91888952
46MP0005375_adipose_tissue_phenotype0.89942345
47MP0002822_catalepsy0.83140523
48MP0000003_abnormal_adipose_tissue0.80635485
49MP0003828_pulmonary_edema0.78959078
50MP0009780_abnormal_chondrocyte_physiolo0.75385227
51MP0003045_fibrosis0.72440391
52MP0000372_irregular_coat_pigmentation0.71394814
53MP0000266_abnormal_heart_morphology0.68806143
54MP0004147_increased_porphyrin_level0.65756592
55MP0003656_abnormal_erythrocyte_physiolo0.57618318
56MP0003879_abnormal_hair_cell0.55880475
57MP0001299_abnormal_eye_distance/0.55379728
58MP0004134_abnormal_chest_morphology0.53216104
59MP0004043_abnormal_pH_regulation0.50710760
60MP0002078_abnormal_glucose_homeostasis0.50091526
61MP0005165_increased_susceptibility_to0.49050744
62MP0002638_abnormal_pupillary_reflex0.44897205
63MP0008569_lethality_at_weaning0.44018815
64MP0002128_abnormal_blood_circulation0.43554133
65MP0005167_abnormal_blood-brain_barrier0.41201938
66MP0004142_abnormal_muscle_tone0.38823873
67MP0005376_homeostasis/metabolism_phenot0.37066224
68MP0005584_abnormal_enzyme/coenzyme_acti0.36968179
69MP0009672_abnormal_birth_weight0.34616436
70MP0005535_abnormal_body_temperature0.34476938
71MP0005452_abnormal_adipose_tissue0.31929411
72MP0000230_abnormal_systemic_arterial0.30930558
73MP0005083_abnormal_biliary_tract0.30530770
74MP0003948_abnormal_gas_homeostasis0.30520315
75MP0006035_abnormal_mitochondrial_morpho0.30435404
76MP0005334_abnormal_fat_pad0.29793088
77MP0000762_abnormal_tongue_morphology0.29779866
78MP0002114_abnormal_axial_skeleton0.29291179
79MP0005423_abnormal_somatic_nervous0.29039082
80MP0005166_decreased_susceptibility_to0.28497553
81MP0010030_abnormal_orbit_morphology0.28135178
82MP0005332_abnormal_amino_acid0.26914973
83MP0005187_abnormal_penis_morphology0.26831337
84MP0005319_abnormal_enzyme/_coenzyme0.25851344
85MP0001346_abnormal_lacrimal_gland0.25666313
86MP0009250_abnormal_appendicular_skeleto0.25109845
87MP0002734_abnormal_mechanical_nocicepti0.24573121
88MP0002896_abnormal_bone_mineralization0.23907150
89MP0002066_abnormal_motor_capabilities/c0.21105728
90MP0001943_abnormal_respiration0.20320436
91MP0006276_abnormal_autonomic_nervous0.19205631
92MP0005386_behavior/neurological_phenoty0.16721900
93MP0004924_abnormal_behavior0.16721900
94MP0009115_abnormal_fat_cell0.15514075
95MP0002067_abnormal_sensory_capabilities0.13861928
96MP0000343_altered_response_to0.13694678
97MP0003959_abnormal_lean_body0.13266508
98MP0002876_abnormal_thyroid_physiology0.12222986
99MP0001984_abnormal_olfaction0.11857653
100MP0002234_abnormal_pharynx_morphology0.11565039

Predicted human phenotypes

RankGene SetZ-score
1Type 1 muscle fiber predominance (HP:0003803)8.31178456
2Exercise-induced myalgia (HP:0003738)7.97847271
3Exercise-induced muscle cramps (HP:0003710)7.47898640
4Muscle hypertrophy of the lower extremities (HP:0008968)6.39917010
5Calf muscle hypertrophy (HP:0008981)5.82485417
6Distal arthrogryposis (HP:0005684)5.62615562
7Myopathic facies (HP:0002058)5.62581797
8EMG: myopathic abnormalities (HP:0003458)5.48853885
9Muscle fiber splitting (HP:0003555)5.09427268
10Hyporeflexia of lower limbs (HP:0002600)4.98946356
11Rhabdomyolysis (HP:0003201)4.91693852
12Abnormality of the calf musculature (HP:0001430)4.88401109
13Myoglobinuria (HP:0002913)4.87785024
14Centrally nucleated skeletal muscle fibers (HP:0003687)4.71678673
15Round ear (HP:0100830)4.60690561
16Neck muscle weakness (HP:0000467)4.54854397
17Rimmed vacuoles (HP:0003805)4.45984403
18Subaortic stenosis (HP:0001682)4.40008379
19Abnormality of the left ventricular outflow tract (HP:0011103)4.40008379
20Ulnar deviation of the wrist (HP:0003049)4.28940283
21Abnormality of skeletal muscle fiber size (HP:0012084)4.26300412
22Sudden death (HP:0001699)4.04855802
23Difficulty running (HP:0009046)4.03598609
24Increased connective tissue (HP:0009025)3.81228189
25Distal lower limb muscle weakness (HP:0009053)3.80197866
26Calcaneovalgus deformity (HP:0001848)3.76384484
27Asymmetric septal hypertrophy (HP:0001670)3.70352571
28Bundle branch block (HP:0011710)3.67033362
29Muscle stiffness (HP:0003552)3.61128819
30Increased variability in muscle fiber diameter (HP:0003557)3.54735777
31Frequent falls (HP:0002359)3.48921648
32Absent phalangeal crease (HP:0006109)3.43222970
33Areflexia of lower limbs (HP:0002522)3.40405413
34Deformed tarsal bones (HP:0008119)3.33906809
35Myotonia (HP:0002486)3.30214155
36EMG: neuropathic changes (HP:0003445)3.28057200
37Malignant hyperthermia (HP:0002047)3.02598851
38Generalized muscle weakness (HP:0003324)2.96016154
39Ventricular tachycardia (HP:0004756)2.95139724
40Abnormal finger flexion creases (HP:0006143)2.83983279
41Mildly elevated creatine phosphokinase (HP:0008180)2.82534248
42Dilated cardiomyopathy (HP:0001644)2.81441258
43Lipoatrophy (HP:0100578)2.61582962
44Distal lower limb amyotrophy (HP:0008944)2.59148324
45Bulbar palsy (HP:0001283)2.56345388
46Slender build (HP:0001533)2.47777893
47Scapular winging (HP:0003691)2.43061524
48Weak cry (HP:0001612)2.40601205
49Fetal akinesia sequence (HP:0001989)2.37483742
50Progressive muscle weakness (HP:0003323)2.35799521
51Limb-girdle muscle atrophy (HP:0003797)2.35753679
52Gowers sign (HP:0003391)2.34581703
53Heart block (HP:0012722)2.31906189
54Hyperkalemia (HP:0002153)2.31245579
55Abnormality of the neuromuscular junction (HP:0003398)2.21852562
56Fatigable weakness (HP:0003473)2.21852562
57Spinal rigidity (HP:0003306)2.19744523
58Muscular dystrophy (HP:0003560)2.19724373
59Abnormality of the foot musculature (HP:0001436)2.18041847
60Abnormal atrioventricular conduction (HP:0005150)2.17113538
61Proximal amyotrophy (HP:0007126)2.13677678
62Abnormality of the calcaneus (HP:0008364)2.12850298
63Hip contracture (HP:0003273)2.12174236
64Difficulty climbing stairs (HP:0003551)2.11213342
65Ragged-red muscle fibers (HP:0003200)2.05695031
66Waddling gait (HP:0002515)2.04611377
67Ventricular arrhythmia (HP:0004308)2.01436479
68Nemaline bodies (HP:0003798)10.9225762
69Muscle fiber inclusion bodies (HP:0100299)10.9221280
70Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)10.5842161
71Abnormality of the shoulder girdle musculature (HP:0001435)1.99030606
72Foot dorsiflexor weakness (HP:0009027)1.96687510
73Lower limb amyotrophy (HP:0007210)1.96304325
74Exercise intolerance (HP:0003546)1.84121534
75Respiratory insufficiency due to muscle weakness (HP:0002747)1.82347841
76Abnormality of the musculature of the pelvis (HP:0001469)1.78651801
77Abnormality of the hip-girdle musculature (HP:0001445)1.78651801
78Shoulder girdle muscle weakness (HP:0003547)1.71669192
79Pelvic girdle muscle weakness (HP:0003749)1.70896697
80Limb-girdle muscle weakness (HP:0003325)1.70349359
81Long clavicles (HP:0000890)1.68548280
82Facial diplegia (HP:0001349)1.66054167
83Paralysis (HP:0003470)1.65255542
84Increased intramyocellular lipid droplets (HP:0012240)1.63989250
85Atrial fibrillation (HP:0005110)1.62658469
86Nonprogressive disorder (HP:0003680)1.59778431
87Increased muscle lipid content (HP:0009058)1.53033383
88Ventricular fibrillation (HP:0001663)1.51209160
89Popliteal pterygium (HP:0009756)1.48853292
90Steppage gait (HP:0003376)1.48018256
91Syncope (HP:0001279)1.47797850
92Primary atrial arrhythmia (HP:0001692)1.47371712
93Atrioventricular block (HP:0001678)1.46991948
94Palpitations (HP:0001962)1.46535525
95Type 2 muscle fiber atrophy (HP:0003554)1.45726319
96Metatarsus adductus (HP:0001840)1.45489289
97Ulnar deviation of finger (HP:0009465)1.44917674
98Oligomenorrhea (HP:0000876)1.43292576
99Supraventricular tachycardia (HP:0004755)1.42303341
100Limited hip movement (HP:0008800)1.42075319

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN6.44010909
2PHKG15.96178279
3PHKG25.96178279
4PIK3CG2.74070009
5PINK12.02282432
6OBSCN10.9470161
7MAPK121.96622783
8MUSK1.75039177
9MAP3K71.70771751
10MAP2K31.68462875
11DMPK1.29259589
12MAPKAPK31.28314913
13TRPM71.22561489
14MARK11.20566234
15MAP2K41.12801405
16NEK11.06290535
17NME11.06259650
18LIMK10.98404879
19EEF2K0.96856876
20PRKAA20.91294394
21CAMK2G0.89840191
22CCNB10.86489625
23PDK20.84325787
24MOS0.79779925
25MAP2K60.78403100
26PRKAA10.77362189
27ERBB30.74421354
28CAMK40.69972013
29NEK90.69700718
30DYRK1B0.66494992
31MAPK70.66280147
32CAMK2D0.66255222
33BCKDK0.62573337
34AKT20.60194123
35PIK3CA0.57205855
36RIPK10.55518982
37PKN10.55146342
38PRKG10.53687487
39MAPK40.51587135
40CAMK10.50856942
41CAMK2A0.50175398
42MAPK110.49516902
43MAP3K130.48936659
44ROCK10.47662420
45MAP2K10.47514170
46MYLK0.46180336
47CAMK2B0.45935920
48KSR20.44567818
49TRIB30.43805949
50TIE10.42709734
51SGK30.42547681
52ICK0.39331151
53PRKACA0.35476573
54SGK20.32396163
55LATS20.30695460
56RPS6KA30.28191535
57PRKD10.27304189
58TBK10.25477968
59PRKACB0.24593261
60SGK10.24519089
61MAPK130.23548555
62RPS6KB10.23164532
63RPS6KC10.22690017
64RPS6KL10.22690017
65MAPK100.22656997
66RPS6KA10.22033922
67MAP3K10.20236792
68PRKACG0.19325246
69RPS6KA60.18557278
70LATS10.18213875
71PDPK10.17696796
72TAOK20.16714586
73MARK20.16653858
74MAP3K60.16051466
75DAPK20.15550862
76RPS6KB20.15107273
77MARK30.14064714
78EPHA30.14059902
79EPHB10.13823370
80PDK10.12696245
81GRK70.12512178
82SGK2230.12500238
83SGK4940.12500238
84MTOR0.12397013
85PAK30.12200206
86PRPF4B0.11698981
87STK110.11404512
88SIK10.11295203
89ZAP700.08881411
90TGFBR20.08493363
91CDC42BPA0.07902195
92RAF10.07721995
93MAP3K100.04987952
94KSR10.04766957
95NLK0.04756642
96MAPK90.04450967
97ARAF0.03991936
98MAP3K50.03571393
99ROCK20.02885475
100GSK3B0.02880083

Predicted pathways (KEGG)

RankGene SetZ-score
1Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.71315297
2Cardiac muscle contraction_Homo sapiens_hsa042604.33374306
3Dilated cardiomyopathy_Homo sapiens_hsa054144.31084592
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.18470216
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.99139061
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.59605540
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.29077205
8Circadian rhythm_Homo sapiens_hsa047102.56817496
9Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.30619757
10Carbon metabolism_Homo sapiens_hsa012002.20315557
11Glucagon signaling pathway_Homo sapiens_hsa049222.14574953
12Arginine and proline metabolism_Homo sapiens_hsa003301.99599560
13Insulin signaling pathway_Homo sapiens_hsa049101.94345765
14Arginine biosynthesis_Homo sapiens_hsa002201.82912680
15Pentose phosphate pathway_Homo sapiens_hsa000301.81040994
16Oxytocin signaling pathway_Homo sapiens_hsa049211.75034374
17Calcium signaling pathway_Homo sapiens_hsa040201.73069053
18Propanoate metabolism_Homo sapiens_hsa006401.70492997
19Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.68250120
20Parkinsons disease_Homo sapiens_hsa050121.61882270
21Insulin resistance_Homo sapiens_hsa049311.59339625
22Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.59160802
23Pyruvate metabolism_Homo sapiens_hsa006201.58468222
24Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.56823054
25Fructose and mannose metabolism_Homo sapiens_hsa000511.52679184
26Alzheimers disease_Homo sapiens_hsa050101.49059478
27cGMP-PKG signaling pathway_Homo sapiens_hsa040221.43719975
28Fatty acid degradation_Homo sapiens_hsa000711.41330268
29AMPK signaling pathway_Homo sapiens_hsa041521.26449159
30Oxidative phosphorylation_Homo sapiens_hsa001901.23861529
31Biosynthesis of amino acids_Homo sapiens_hsa012301.21621302
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.19486997
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.19324725
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.17945763
35Adipocytokine signaling pathway_Homo sapiens_hsa049201.15217657
36Starch and sucrose metabolism_Homo sapiens_hsa005001.15033944
37Vascular smooth muscle contraction_Homo sapiens_hsa042701.08280687
38Phenylalanine metabolism_Homo sapiens_hsa003601.05424934
39Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.04953638
40Fatty acid metabolism_Homo sapiens_hsa012120.96653080
41Nitrogen metabolism_Homo sapiens_hsa009100.95232161
42Gastric acid secretion_Homo sapiens_hsa049710.93081752
43Renin secretion_Homo sapiens_hsa049240.91095131
44Viral myocarditis_Homo sapiens_hsa054160.82978561
45Tight junction_Homo sapiens_hsa045300.79618377
46GnRH signaling pathway_Homo sapiens_hsa049120.74387116
47Huntingtons disease_Homo sapiens_hsa050160.72983477
48Galactose metabolism_Homo sapiens_hsa000520.67452824
49Long-term potentiation_Homo sapiens_hsa047200.67242622
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66186606
51Insulin secretion_Homo sapiens_hsa049110.65902071
52Butanoate metabolism_Homo sapiens_hsa006500.63758724
53PPAR signaling pathway_Homo sapiens_hsa033200.61110605
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.56686991
55Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55989874
56Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52315364
57Fatty acid elongation_Homo sapiens_hsa000620.52265205
58Circadian entrainment_Homo sapiens_hsa047130.52031209
59Focal adhesion_Homo sapiens_hsa045100.51883830
60beta-Alanine metabolism_Homo sapiens_hsa004100.50815673
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49518636
62FoxO signaling pathway_Homo sapiens_hsa040680.49299927
63Tryptophan metabolism_Homo sapiens_hsa003800.47299935
64Aldosterone synthesis and secretion_Homo sapiens_hsa049250.45526227
65Salivary secretion_Homo sapiens_hsa049700.42192653
66Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.38969751
67Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.37648519
68Peroxisome_Homo sapiens_hsa041460.36599247
69cAMP signaling pathway_Homo sapiens_hsa040240.35678793
70MAPK signaling pathway_Homo sapiens_hsa040100.35608113
71Lysine degradation_Homo sapiens_hsa003100.35385362
72Cholinergic synapse_Homo sapiens_hsa047250.33853304
73Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.32294759
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.30618978
75Long-term depression_Homo sapiens_hsa047300.30569467
76Regulation of autophagy_Homo sapiens_hsa041400.29692380
77Pancreatic secretion_Homo sapiens_hsa049720.26574773
78Tyrosine metabolism_Homo sapiens_hsa003500.25688941
79mTOR signaling pathway_Homo sapiens_hsa041500.25346981
80Histidine metabolism_Homo sapiens_hsa003400.24266981
81Ovarian steroidogenesis_Homo sapiens_hsa049130.24134080
82Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.22197365
83Platelet activation_Homo sapiens_hsa046110.22165357
84Amphetamine addiction_Homo sapiens_hsa050310.22025546
85VEGF signaling pathway_Homo sapiens_hsa043700.18993364
86HIF-1 signaling pathway_Homo sapiens_hsa040660.18721873
87Purine metabolism_Homo sapiens_hsa002300.18424572
88Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.15363728
89Adherens junction_Homo sapiens_hsa045200.14977013
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.14907592
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.14578185
92Olfactory transduction_Homo sapiens_hsa047400.13858943
93Bile secretion_Homo sapiens_hsa049760.12550551
94Melanogenesis_Homo sapiens_hsa049160.12087994
95Amoebiasis_Homo sapiens_hsa051460.10918041
96Glioma_Homo sapiens_hsa052140.10455348
97Cysteine and methionine metabolism_Homo sapiens_hsa002700.10385503
98Oocyte meiosis_Homo sapiens_hsa041140.08218180
99Metabolic pathways_Homo sapiens_hsa011000.08166354
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.07806467

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