C10ORF107

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1left/right pattern formation (GO:0060972)8.71034838
2regulation of cilium movement (GO:0003352)7.42773672
3ventricular system development (GO:0021591)7.34596939
4intraciliary transport (GO:0042073)6.79944139
5left/right axis specification (GO:0070986)6.67013187
6primary alcohol catabolic process (GO:0034310)6.38215772
7cilium organization (GO:0044782)6.28297239
8microtubule bundle formation (GO:0001578)6.18505988
9cilium assembly (GO:0042384)6.07821021
10vitamin transmembrane transport (GO:0035461)5.65619288
11ethanol metabolic process (GO:0006067)5.45394077
12diterpenoid biosynthetic process (GO:0016102)5.36433748
13protein localization to cilium (GO:0061512)4.91363217
14cellular component assembly involved in morphogenesis (GO:0010927)4.89582636
15cilium morphogenesis (GO:0060271)4.88016021
16one-carbon compound transport (GO:0019755)4.87863682
17centriole assembly (GO:0098534)4.87142758
18microtubule-based movement (GO:0007018)4.75659148
19pyrimidine-containing compound transmembrane transport (GO:0072531)4.68493104
20sperm capacitation (GO:0048240)4.67106908
21lung epithelium development (GO:0060428)4.51740750
22regulation of microtubule-based movement (GO:0060632)4.39733503
23cell projection assembly (GO:0030031)4.31714716
24ethanol oxidation (GO:0006069)4.31011500
25nucleoside diphosphate phosphorylation (GO:0006165)4.18449030
26response to xenobiotic stimulus (GO:0009410)4.00504956
27glomerular epithelial cell development (GO:0072310)3.97878076
28establishment of apical/basal cell polarity (GO:0035089)3.89977651
29retinoic acid metabolic process (GO:0042573)3.86811500
30tolerance induction (GO:0002507)3.81504986
31negative regulation of humoral immune response (GO:0002921)3.80225008
32negative regulation of T cell differentiation in thymus (GO:0033085)3.75571274
33regulation of interleukin-5 production (GO:0032674)3.70477039
34terpenoid biosynthetic process (GO:0016114)3.67105513
35negative regulation of B cell mediated immunity (GO:0002713)3.66035568
36negative regulation of immunoglobulin mediated immune response (GO:0002890)3.66035568
37retinol metabolic process (GO:0042572)3.62457524
38negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.58122272
39cytoplasmic microtubule organization (GO:0031122)3.55462369
40lateral ventricle development (GO:0021670)3.48791952
41determination of left/right symmetry (GO:0007368)3.46308504
42establishment of monopolar cell polarity (GO:0061162)3.42772032
43establishment or maintenance of monopolar cell polarity (GO:0061339)3.42772032
44determination of bilateral symmetry (GO:0009855)3.35044447
45primary alcohol metabolic process (GO:0034308)3.31916971
46regulation of germinal center formation (GO:0002634)3.31129848
47specification of symmetry (GO:0009799)3.28213014
48glutathione derivative metabolic process (GO:1901685)3.17299677
49glutathione derivative biosynthetic process (GO:1901687)3.17299677
50regulation of interleukin-13 production (GO:0032656)3.16245817
51nonmotile primary cilium assembly (GO:0035058)3.14522090
52smoothened signaling pathway (GO:0007224)3.13390040
53aldehyde catabolic process (GO:0046185)3.13131530
54exogenous drug catabolic process (GO:0042738)3.10567632
55CDP-diacylglycerol biosynthetic process (GO:0016024)3.10259293
56sperm motility (GO:0030317)3.06563818
57retinal rod cell development (GO:0046548)3.02623705
58positive regulation of tolerance induction (GO:0002645)3.02144433
59carnitine metabolic process (GO:0009437)3.00519126
60axonemal dynein complex assembly (GO:0070286)20.6746212
61establishment of tissue polarity (GO:0007164)2.98210672
62establishment of planar polarity (GO:0001736)2.98210672
63positive regulation of smoothened signaling pathway (GO:0045880)2.94729598
64O-glycan processing (GO:0016266)2.93414331
65negative regulation of inclusion body assembly (GO:0090084)2.92954706
66centriole replication (GO:0007099)2.89401161
67regulation of autophagic vacuole assembly (GO:2000785)2.75979791
68microtubule-based process (GO:0007017)2.74164035
69CDP-diacylglycerol metabolic process (GO:0046341)2.67922294
70organelle assembly (GO:0070925)2.61456478
71microtubule polymerization or depolymerization (GO:0031109)2.60224529
72microtubule depolymerization (GO:0007019)2.60014169
73apical protein localization (GO:0045176)2.57467734
74hydrogen peroxide biosynthetic process (GO:0050665)2.56230132
75photoreceptor cell maintenance (GO:0045494)2.53279247
76multicellular organismal water homeostasis (GO:0050891)2.49879358
77oligosaccharide biosynthetic process (GO:0009312)2.45393335
78regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.44636565
79intra-S DNA damage checkpoint (GO:0031573)2.44376036
80iron ion import (GO:0097286)2.43926431
81regulation of vacuole organization (GO:0044088)2.43563864
82regulation of microtubule depolymerization (GO:0031114)2.43556850
83phosphatidylcholine biosynthetic process (GO:0006656)2.43370953
84excretion (GO:0007588)2.42997632
85heart looping (GO:0001947)2.41591097
86eye photoreceptor cell differentiation (GO:0001754)2.41426480
87photoreceptor cell differentiation (GO:0046530)2.41426480
88drug catabolic process (GO:0042737)2.38225519
89progesterone metabolic process (GO:0042448)2.33175534
90nucleotide phosphorylation (GO:0046939)2.33165980
91phenol-containing compound catabolic process (GO:0019336)2.32014317
92regulation of collateral sprouting (GO:0048670)2.30625821
93regulation of smoothened signaling pathway (GO:0008589)2.28377215
94water homeostasis (GO:0030104)2.26305802
95cilium or flagellum-dependent cell motility (GO:0001539)17.1069455
96cilium movement (GO:0003341)16.0234735
97epithelial cilium movement (GO:0003351)14.3557182
98motile cilium assembly (GO:0044458)14.1595523
99epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)14.1289580
100axoneme assembly (GO:0035082)10.4097250

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.64082677
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.84911824
3FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.80865413
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.76858806
5DROSHA_22980978_ChIP-Seq_HELA_Human2.49060401
6* PIAS1_25552417_ChIP-Seq_VCAP_Human2.34397020
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.30424425
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.24878364
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.22155160
10AHR_22903824_ChIP-Seq_MCF-7_Human1.96988084
11ESR1_20079471_ChIP-ChIP_T-47D_Human1.93979772
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.89130367
13FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.85697668
14NR3C1_21868756_ChIP-Seq_MCF10A_Human1.84022025
15ZNF217_24962896_ChIP-Seq_MCF-7_Human1.81603676
16* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.81058248
17ARNT_22903824_ChIP-Seq_MCF-7_Human1.80597372
18SMAD4_21799915_ChIP-Seq_A2780_Human1.62606724
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59302536
20VDR_22108803_ChIP-Seq_LS180_Human1.58356691
21AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.56972513
22* TP63_23658742_ChIP-Seq_EP156T_Human1.56619942
23TOP2B_26459242_ChIP-Seq_MCF-7_Human1.56239640
24TP53_18474530_ChIP-ChIP_U2OS_Human1.56172871
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.54324580
26ESR1_21235772_ChIP-Seq_MCF-7_Human1.52521545
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.50927365
28CTNNB1_20460455_ChIP-Seq_HCT116_Human1.41481008
29SOX2_20726797_ChIP-Seq_SW620_Human1.40459318
30SOX2_27498859_Chip-Seq_STOMACH_Mouse1.40006577
31ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.39724130
32FOXA1_25552417_ChIP-Seq_VCAP_Human1.37797570
33TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.36068723
34* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.35348539
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34046064
36TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33340595
37* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32692283
38ETV1_20927104_ChIP-Seq_GIST48_Human1.25694710
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.25556628
40CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.25168204
41* STAT3_23295773_ChIP-Seq_U87_Human1.24910351
42PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.24038203
43* STAT1_20625510_ChIP-Seq_HELA_Human1.19606872
44* PHF8_20622853_ChIP-Seq_HELA_Human1.19522755
45* BCAT_22108803_ChIP-Seq_LS180_Human1.19378930
46MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18176467
47* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18033880
48RUNX1_27514584_Chip-Seq_MCF-7_Human1.18028711
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.17087558
50* SMRT_27268052_Chip-Seq_Bcells_Human1.16636725
51* TCF4_22108803_ChIP-Seq_LS180_Human1.16410258
52* HNFA_21074721_ChIP-Seq_CACO-2_Human1.16105541
53CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.15810602
54CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15030791
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.12615055
56CDX2_20551321_ChIP-Seq_CACO-2_Human1.10776834
57* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.10533396
58PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.10394711
59TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10280471
60GBX2_23144817_ChIP-Seq_PC3_Human1.07773452
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.07627235
62SOX9_24532713_ChIP-Seq_HFSC_Mouse1.07056516
63RAD21_21589869_ChIP-Seq_MESCs_Mouse1.07017011
64STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.06660601
65* TBL1_22424771_ChIP-Seq_293T_Human1.05390922
66SMAD3_21741376_ChIP-Seq_HESCs_Human1.05350628
67RBPJ_21746931_ChIP-Seq_IB4_Human1.04530531
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04333745
69FOXA1_25329375_ChIP-Seq_VCAP_Human1.04044723
70FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04044723
71* CDX2_22108803_ChIP-Seq_LS180_Human1.03083766
72KLF5_25053715_ChIP-Seq_YYC3_Human1.02531422
73ER_23166858_ChIP-Seq_MCF-7_Human1.01748048
74GATA4_25053715_ChIP-Seq_YYC3_Human1.01666581
75AR_20517297_ChIP-Seq_VCAP_Human1.01379871
76P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00139377
77* NFYA_21822215_ChIP-Seq_K562_Human0.99961880
78AR_25329375_ChIP-Seq_VCAP_Human0.99725368
79FOXA2_19822575_ChIP-Seq_HepG2_Human0.99549899
80PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99404051
81CBX2_22325352_ChIP-Seq_293T-Rex_Human0.99256775
82EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99154697
83FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.99100910
84* TCF4_23295773_ChIP-Seq_U87_Human0.98562211
85CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.98507677
86RUNX2_22187159_ChIP-Seq_PCA_Human0.98284034
87SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98148068
88* NFYB_21822215_ChIP-Seq_K562_Human0.97917301
89NRF2_20460467_ChIP-Seq_MEFs_Mouse0.97168550
90NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.97168550
91BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96344301
92AR_21572438_ChIP-Seq_LNCaP_Human0.96111629
93P300_19829295_ChIP-Seq_ESCs_Human0.94406751
94GATA3_24758297_ChIP-Seq_MCF-7_Human0.94019290
95FUS_26573619_Chip-Seq_HEK293_Human0.93321700
96FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.92873093
97CBP_20019798_ChIP-Seq_JUKART_Human0.92435353
98IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92435353
99TAF15_26573619_Chip-Seq_HEK293_Human0.92325293
100ZFP57_27257070_Chip-Seq_ESCs_Mouse0.91906543

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology5.90004067
2MP0008875_abnormal_xenobiotic_pharmacok5.75023948
3MP0001984_abnormal_olfaction4.40798116
4MP0002132_abnormal_respiratory_system3.97095068
5MP0004043_abnormal_pH_regulation3.94075979
6MP0000383_abnormal_hair_follicle3.69347778
7MP0004133_heterotaxia3.55863830
8MP0009780_abnormal_chondrocyte_physiolo3.39255187
9MP0005623_abnormal_meninges_morphology3.36929493
10MP0010678_abnormal_skin_adnexa3.25658307
11MP0008789_abnormal_olfactory_epithelium3.10206419
12MP0000566_synostosis3.04736801
13MP0003283_abnormal_digestive_organ2.77864761
14MP0002277_abnormal_respiratory_mucosa2.74267147
15MP0004019_abnormal_vitamin_homeostasis2.32714131
16MP0002909_abnormal_adrenal_gland2.11652258
17MP0005499_abnormal_olfactory_system2.07355320
18MP0005394_taste/olfaction_phenotype2.07355320
19MP0002282_abnormal_trachea_morphology2.03377075
20MP0002638_abnormal_pupillary_reflex1.88720174
21MP0003656_abnormal_erythrocyte_physiolo1.80632636
22MP0003878_abnormal_ear_physiology1.69576498
23MP0005377_hearing/vestibular/ear_phenot1.69576498
24MP0002168_other_aberrant_phenotype1.68660279
25MP0010234_abnormal_vibrissa_follicle1.64995386
26MP0001765_abnormal_ion_homeostasis1.64498004
27MP0005248_abnormal_Harderian_gland1.44378781
28MP0005220_abnormal_exocrine_pancreas1.43872810
29MP0002734_abnormal_mechanical_nocicepti1.43118119
30MP0009046_muscle_twitch1.42389889
31MP0005083_abnormal_biliary_tract1.40344830
32MP0002160_abnormal_reproductive_system1.40325642
33MP0005253_abnormal_eye_physiology1.39210108
34MP0005365_abnormal_bile_salt1.32732961
35MP0003136_yellow_coat_color1.29279925
36MP0002876_abnormal_thyroid_physiology1.28842033
37MP0005636_abnormal_mineral_homeostasis1.17551194
38MP0001485_abnormal_pinna_reflex1.15307488
39MP0002233_abnormal_nose_morphology1.15122380
40MP0003011_delayed_dark_adaptation1.13038471
41MP0010030_abnormal_orbit_morphology1.05849376
42MP0001346_abnormal_lacrimal_gland1.04320340
43MP0005408_hypopigmentation1.02239236
44MP0001944_abnormal_pancreas_morphology1.01758878
45MP0005395_other_phenotype0.94667767
46MP0005551_abnormal_eye_electrophysiolog0.92104844
47MP0005503_abnormal_tendon_morphology0.90166449
48MP0000026_abnormal_inner_ear0.89994920
49MP0001270_distended_abdomen0.84923514
50MP0001502_abnormal_circadian_rhythm0.84670825
51MP0000013_abnormal_adipose_tissue0.83744831
52MP0005165_increased_susceptibility_to0.83585942
53MP0001293_anophthalmia0.83419304
54MP0005085_abnormal_gallbladder_physiolo0.82951882
55MP0002098_abnormal_vibrissa_morphology0.82430307
56MP0005391_vision/eye_phenotype0.80425675
57MP0003937_abnormal_limbs/digits/tail_de0.78385602
58MP0003938_abnormal_ear_development0.77107019
59MP0009643_abnormal_urine_homeostasis0.76620830
60MP0003806_abnormal_nucleotide_metabolis0.75011278
61MP0006036_abnormal_mitochondrial_physio0.74839112
62MP0005171_absent_coat_pigmentation0.74537909
63MP0005164_abnormal_response_to0.74253596
64MP0001486_abnormal_startle_reflex0.73305337
65MP0000678_abnormal_parathyroid_gland0.72832373
66MP0004883_abnormal_blood_vessel0.72059911
67MP0002928_abnormal_bile_duct0.71966795
68MP0002249_abnormal_larynx_morphology0.71847777
69MP0001324_abnormal_eye_pigmentation0.71291581
70MP0005195_abnormal_posterior_eye0.71163491
71MP0001929_abnormal_gametogenesis0.69772860
72MP0001664_abnormal_digestion0.68260752
73MP0002136_abnormal_kidney_physiology0.67779370
74MP0000427_abnormal_hair_cycle0.67600051
75MP0004885_abnormal_endolymph0.63967777
76MP0003698_abnormal_male_reproductive0.62448899
77MP0005389_reproductive_system_phenotype0.62337160
78MP0001963_abnormal_hearing_physiology0.62315001
79MP0001529_abnormal_vocalization0.61405836
80MP0008995_early_reproductive_senescence0.61108004
81MP0002896_abnormal_bone_mineralization0.60103504
82MP0002229_neurodegeneration0.59146714
83MP0000681_abnormal_thyroid_gland0.58271822
84MP0009765_abnormal_xenobiotic_induced0.58174043
85MP0001970_abnormal_pain_threshold0.57337768
86MP0003633_abnormal_nervous_system0.56787225
87MP0002735_abnormal_chemical_nociception0.56235557
88MP0000465_gastrointestinal_hemorrhage0.56077239
89MP0010155_abnormal_intestine_physiology0.55942881
90MP0006072_abnormal_retinal_apoptosis0.55209426
91MP0004270_analgesia0.54936029
92MP0009745_abnormal_behavioral_response0.53591645
93MP0009703_decreased_birth_body0.52480425
94MP0010386_abnormal_urinary_bladder0.52419218
95MP0002139_abnormal_hepatobiliary_system0.52325339
96MP0000613_abnormal_salivary_gland0.52145661
97MP0005646_abnormal_pituitary_gland0.49595840
98MP0002116_abnormal_craniofacial_bone0.49375251
99MP0003941_abnormal_skin_development0.48725450
100MP0002295_abnormal_pulmonary_circulatio0.47585882

Predicted human phenotypes

RankGene SetZ-score
1Rhinitis (HP:0012384)9.97008600
2Chronic bronchitis (HP:0004469)7.85885033
3Bronchiectasis (HP:0002110)7.14386646
4Nasal polyposis (HP:0100582)6.45904961
5Abnormality of the nasal mucosa (HP:0000433)5.34252872
6Bronchitis (HP:0012387)4.18605245
7Recurrent sinusitis (HP:0011108)4.07693078
8Chronic sinusitis (HP:0011109)4.05376241
9Infertility (HP:0000789)4.03938453
10Occipital encephalocele (HP:0002085)3.90721024
11Male infertility (HP:0003251)3.73798942
12True hermaphroditism (HP:0010459)3.72971704
13Pancreatic fibrosis (HP:0100732)3.71421973
14Recurrent otitis media (HP:0000403)3.55523955
15Molar tooth sign on MRI (HP:0002419)3.42808301
16Abnormality of midbrain morphology (HP:0002418)3.42808301
17Nephronophthisis (HP:0000090)3.06774748
18Pancreatic cysts (HP:0001737)3.04633329
19Cystic liver disease (HP:0006706)2.99036719
20Hyperactive renin-angiotensin system (HP:0000841)2.82149819
21Chronic otitis media (HP:0000389)2.80962423
22Chronic hepatic failure (HP:0100626)2.73821686
23Medial flaring of the eyebrow (HP:0010747)2.72484218
24Atelectasis (HP:0100750)2.69947327
25Tubulointerstitial nephritis (HP:0001970)2.60529914
26Postaxial foot polydactyly (HP:0001830)2.58089195
27Abnormality of the renal medulla (HP:0100957)2.39350659
28Congenital primary aphakia (HP:0007707)2.30978773
29Gait imbalance (HP:0002141)2.28255036
30Aplasia/Hypoplasia of the tongue (HP:0010295)2.18256762
31Congenital hepatic fibrosis (HP:0002612)2.16054064
32Tubular atrophy (HP:0000092)2.01686533
33Nephrogenic diabetes insipidus (HP:0009806)2.01562214
34Oculomotor apraxia (HP:0000657)2.00307302
35Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.2567839
36Abnormal respiratory motile cilium physiology (HP:0012261)10.9670011
37Abnormal respiratory motile cilium morphology (HP:0005938)10.8253148
38Abnormal respiratory epithelium morphology (HP:0012253)10.8253148
39Abnormal ciliary motility (HP:0012262)10.7757517
40Dynein arm defect of respiratory motile cilia (HP:0012255)10.5649755
41Absent/shortened dynein arms (HP:0200106)10.5649755
42Male pseudohermaphroditism (HP:0000037)1.98040975
43Anencephaly (HP:0002323)1.96969136
44Decreased circulating renin level (HP:0003351)1.90696876
45Furrowed tongue (HP:0000221)1.86708619
46Postaxial hand polydactyly (HP:0001162)1.86332011
47Bell-shaped thorax (HP:0001591)1.86115762
48Absent frontal sinuses (HP:0002688)1.73927121
49Sclerocornea (HP:0000647)1.71902543
50Recurrent bronchitis (HP:0002837)1.66100391
51Tubulointerstitial abnormality (HP:0001969)1.63984920
52Renal salt wasting (HP:0000127)1.63642898
53Nephropathy (HP:0000112)1.63621192
54Poor coordination (HP:0002370)1.61357265
55Genital tract atresia (HP:0001827)1.60109681
56Vaginal atresia (HP:0000148)1.59715698
57Aplasia/Hypoplasia of the spleen (HP:0010451)1.57670902
58Asplenia (HP:0001746)1.53788913
59Hyperkalemia (HP:0002153)1.51272231
60Short nail (HP:0001799)1.46587854
61Hyperaldosteronism (HP:0000859)1.42429556
62Preaxial hand polydactyly (HP:0001177)1.41349239
63Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.40407404
64Median cleft lip (HP:0000161)1.37750830
65Stage 5 chronic kidney disease (HP:0003774)1.35111643
66Abnormality of renin-angiotensin system (HP:0000847)1.33982179
67Abnormality of dentin (HP:0010299)1.32605979
68Abnormal drinking behavior (HP:0030082)1.31810200
69Polydipsia (HP:0001959)1.31810200
70Abnormality of the dental root (HP:0006486)1.27704418
71Taurodontia (HP:0000679)1.27704418
72Abnormality of permanent molar morphology (HP:0011071)1.27704418
73Supernumerary spleens (HP:0009799)1.27084302
74Tubulointerstitial fibrosis (HP:0005576)1.26379600
75Absent rod-and cone-mediated responses on ERG (HP:0007688)1.25868745
76Cone-rod dystrophy (HP:0000548)1.21259458
77Hypokalemic alkalosis (HP:0001949)1.20719012
78Abnormality of molar (HP:0011077)1.18083069
79Abnormality of molar morphology (HP:0011070)1.18083069
80Abnormality of chloride homeostasis (HP:0011422)1.17663630
81Glucose intolerance (HP:0000833)1.17218762
82Aplasia/Hypoplasia of the lens (HP:0008063)1.16976190
83Abnormality of the renal cortex (HP:0011035)1.16231752
84Prominent nasal bridge (HP:0000426)1.16200793
85Short thorax (HP:0010306)1.14497515
86Abnormality of the dental pulp (HP:0006479)1.14249379
87Large for gestational age (HP:0001520)1.11124802
88Bifid scrotum (HP:0000048)1.10066385
89Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.09849020
90Abnormal rod and cone electroretinograms (HP:0008323)1.09583413
91Retinitis pigmentosa (HP:0000510)1.09378077
92Abnormality of the frontal sinuses (HP:0002687)1.09096721
93Abnormality of abdominal situs (HP:0011620)1.09027435
94Abdominal situs inversus (HP:0003363)1.09027435
95Abnormal biliary tract physiology (HP:0012439)1.08574045
96Bile duct proliferation (HP:0001408)1.08574045
97Narrow forehead (HP:0000341)1.08223982
98Hyponatremia (HP:0002902)1.07636104
99Broad foot (HP:0001769)1.06728569
100Decreased central vision (HP:0007663)1.06105190

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST45.89160799
2EPHA23.88349186
3PTK2B2.62163712
4MAP3K22.50963023
5MAPKAPK32.39110299
6TAF12.03998668
7MAPK1510.6497702
8STK241.82419903
9ERBB31.82033602
10TRPM71.79412119
11NME11.58848865
12SMG11.49926078
13BCR1.44976286
14MAP3K41.38741570
15MAP3K31.31764112
16IRAK11.28404168
17EEF2K1.23840691
18PNCK1.19023054
19TTK1.16448465
20FRK1.10847079
21CSK0.97823452
22MAP3K120.96530826
23NEK60.94255378
24EPHB10.93893859
25ACVR1B0.93545268
26BMPR20.89784300
27HIPK20.89713124
28STK100.88736230
29STK380.87471190
30BMPR1B0.85046608
31LRRK20.80964594
32PRKCI0.78172878
33EPHA30.78042794
34TESK10.75232275
35STK38L0.75004031
36NEK90.73959587
37MAP3K70.72000833
38CAMK2G0.71233640
39CASK0.69888541
40ERBB20.69429717
41SGK20.67368234
42NTRK30.66192713
43PASK0.63975092
44STK390.61848376
45MUSK0.60174704
46SGK2230.54260786
47SGK4940.54260786
48MARK20.53305651
49ROCK20.53236431
50FER0.53037239
51SGK10.51081701
52TLK10.49507207
53LMTK20.48842906
54NLK0.47383444
55MST1R0.46026317
56SGK30.45469628
57STK160.45421590
58PRKAA20.43394068
59TAOK10.42978095
60PRKCE0.42668263
61TBK10.42638459
62RPS6KB20.42438238
63ROCK10.41422608
64PBK0.41043163
65MAP2K70.40372530
66CSNK1G20.40127613
67PAK30.39933089
68CCNB10.38418341
69DYRK1A0.37696458
70AURKA0.37278441
71GRK10.36967032
72DYRK30.36931123
73MAPKAPK50.35416232
74CSNK1G10.35203726
75PRKACA0.34834743
76MAPK130.34607265
77CAMKK10.34182646
78PTK60.33501404
79CAMK2A0.32604684
80PINK10.32424656
81INSRR0.32101421
82MYLK0.32073179
83FGFR30.31908070
84ADRBK10.31517676
85PRKCQ0.30558662
86ERBB40.29758413
87LATS10.27254035
88ABL10.26629200
89PRKCA0.26299476
90PRKCD0.25393115
91KSR20.25040722
92CAMK2D0.24296014
93MAPK110.24083146
94OXSR10.23506902
95ADRBK20.23184117
96PHKG10.21639734
97PHKG20.21639734
98PRKG10.20375128
99MAP2K40.19580499
100PLK20.18947424

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009804.95194020
2Phenylalanine metabolism_Homo sapiens_hsa003604.12151807
3Histidine metabolism_Homo sapiens_hsa003404.05812840
4Chemical carcinogenesis_Homo sapiens_hsa052044.02771928
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.91546694
6Tyrosine metabolism_Homo sapiens_hsa003503.35633967
7beta-Alanine metabolism_Homo sapiens_hsa004103.09151563
8Huntingtons disease_Homo sapiens_hsa050162.65102725
9Glutathione metabolism_Homo sapiens_hsa004802.43438720
10Retinol metabolism_Homo sapiens_hsa008302.24362837
11Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.91989886
12Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.85307697
13Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.77319292
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.74959692
15Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.64580170
16Caffeine metabolism_Homo sapiens_hsa002321.62817763
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.59831587
18ABC transporters_Homo sapiens_hsa020101.57745434
19Sphingolipid metabolism_Homo sapiens_hsa006001.57740315
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.53750313
21Peroxisome_Homo sapiens_hsa041461.49763734
22Collecting duct acid secretion_Homo sapiens_hsa049661.49546169
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.47275405
24Linoleic acid metabolism_Homo sapiens_hsa005911.42988678
25Circadian rhythm_Homo sapiens_hsa047101.41858868
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.37225756
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.33757532
28Fatty acid degradation_Homo sapiens_hsa000711.21613912
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.19119758
30Tight junction_Homo sapiens_hsa045301.14122372
31Salivary secretion_Homo sapiens_hsa049701.09966199
32Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.07625747
33Butanoate metabolism_Homo sapiens_hsa006501.00670878
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.93137692
35Carbohydrate digestion and absorption_Homo sapiens_hsa049730.91586399
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.91006605
37Vitamin B6 metabolism_Homo sapiens_hsa007500.89542535
38Pentose and glucuronate interconversions_Homo sapiens_hsa000400.85919656
39Insulin secretion_Homo sapiens_hsa049110.84121235
40Taste transduction_Homo sapiens_hsa047420.81637781
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.79831291
42Starch and sucrose metabolism_Homo sapiens_hsa005000.77548463
43Hedgehog signaling pathway_Homo sapiens_hsa043400.77163737
44Arachidonic acid metabolism_Homo sapiens_hsa005900.72900275
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.70479597
46Phototransduction_Homo sapiens_hsa047440.69514587
47Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.69378150
48Arginine and proline metabolism_Homo sapiens_hsa003300.65994126
49SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61221752
50Vibrio cholerae infection_Homo sapiens_hsa051100.56330881
51Cocaine addiction_Homo sapiens_hsa050300.54295439
52Glycerophospholipid metabolism_Homo sapiens_hsa005640.52921588
53Metabolic pathways_Homo sapiens_hsa011000.51246412
54Nicotine addiction_Homo sapiens_hsa050330.50942424
55Amphetamine addiction_Homo sapiens_hsa050310.50282429
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.49429465
57Drug metabolism - other enzymes_Homo sapiens_hsa009830.49051483
58Serotonergic synapse_Homo sapiens_hsa047260.48171467
59Propanoate metabolism_Homo sapiens_hsa006400.48109812
60Glycerolipid metabolism_Homo sapiens_hsa005610.47950974
61Glycosaminoglycan degradation_Homo sapiens_hsa005310.47792097
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45218185
63Adherens junction_Homo sapiens_hsa045200.45197762
64Notch signaling pathway_Homo sapiens_hsa043300.44693196
65Mineral absorption_Homo sapiens_hsa049780.44507341
66Protein export_Homo sapiens_hsa030600.44048093
67Olfactory transduction_Homo sapiens_hsa047400.42500157
68Tryptophan metabolism_Homo sapiens_hsa003800.41818270
69Basal cell carcinoma_Homo sapiens_hsa052170.41692386
70Nitrogen metabolism_Homo sapiens_hsa009100.41572667
71Pancreatic secretion_Homo sapiens_hsa049720.41371498
72Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40809831
73cAMP signaling pathway_Homo sapiens_hsa040240.40070741
74Choline metabolism in cancer_Homo sapiens_hsa052310.39737521
75Complement and coagulation cascades_Homo sapiens_hsa046100.38582374
76Synaptic vesicle cycle_Homo sapiens_hsa047210.36906283
77PPAR signaling pathway_Homo sapiens_hsa033200.36755251
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34441807
79Fructose and mannose metabolism_Homo sapiens_hsa000510.33600325
80Regulation of autophagy_Homo sapiens_hsa041400.31209642
81Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.28923442
82Type II diabetes mellitus_Homo sapiens_hsa049300.28135758
83Ether lipid metabolism_Homo sapiens_hsa005650.28103307
84Calcium signaling pathway_Homo sapiens_hsa040200.27817350
85Lysosome_Homo sapiens_hsa041420.27616721
86Bile secretion_Homo sapiens_hsa049760.27338223
87Leukocyte transendothelial migration_Homo sapiens_hsa046700.25313536
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.24269324
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.24233376
90Oxidative phosphorylation_Homo sapiens_hsa001900.24056332
91Dorso-ventral axis formation_Homo sapiens_hsa043200.23848067
92Cardiac muscle contraction_Homo sapiens_hsa042600.23435918
93Hepatitis C_Homo sapiens_hsa051600.22982016
94Circadian entrainment_Homo sapiens_hsa047130.21900005
95Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.20201212
96Pentose phosphate pathway_Homo sapiens_hsa000300.17757367
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.17017790
98Pyruvate metabolism_Homo sapiens_hsa006200.16308268
99N-Glycan biosynthesis_Homo sapiens_hsa005100.15255478
100Inositol phosphate metabolism_Homo sapiens_hsa005620.14899435

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