BVES

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the POP family of proteins containing three putative transmembrane domains. This gene is expressed in cardiac and skeletal muscle and may play an important role in development of these tissues. The mouse ortholog may be involved in the regeneration of adult skeletal muscle and may act as a cell adhesion molecule in coronary vasculogenesis. Three transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1muscle filament sliding (GO:0030049)8.83659562
2actin-myosin filament sliding (GO:0033275)8.83659562
3sarcomere organization (GO:0045214)8.49919971
4cardiac myofibril assembly (GO:0055003)8.42298571
5negative regulation of potassium ion transmembrane transporter activity (GO:1901017)8.33175930
6myofibril assembly (GO:0030239)7.63057604
7actin-mediated cell contraction (GO:0070252)7.41020776
8negative regulation of potassium ion transmembrane transport (GO:1901380)7.36543538
9cardiac muscle contraction (GO:0060048)6.52703604
10regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.42625886
11regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.18020846
12regulation of skeletal muscle contraction (GO:0014819)6.13759059
13positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.12803965
14* cardiac muscle cell development (GO:0055013)5.94514617
15actomyosin structure organization (GO:0031032)5.83899492
16plasma membrane repair (GO:0001778)5.80952917
17tricarboxylic acid cycle (GO:0006099)5.80173562
18striated muscle contraction (GO:0006941)5.75010371
19cardiac muscle tissue morphogenesis (GO:0055008)5.71873107
20sarcoplasmic reticulum calcium ion transport (GO:0070296)5.67876293
21regulation of sarcomere organization (GO:0060297)5.65476216
22regulation of relaxation of muscle (GO:1901077)5.62590682
23* cardiac cell development (GO:0055006)5.57487883
24actin filament-based movement (GO:0030048)5.57384997
25cardiac muscle hypertrophy (GO:0003300)5.48919732
26regulation of actin filament-based movement (GO:1903115)5.47834640
27regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.44617195
28regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.40968641
29ventricular cardiac muscle tissue morphogenesis (GO:0055010)5.33061714
30regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.30464226
31muscle tissue morphogenesis (GO:0060415)5.28875769
32adult heart development (GO:0007512)5.24313099
33striated muscle hypertrophy (GO:0014897)5.24276924
34ventricular cardiac muscle cell action potential (GO:0086005)5.22383897
35heart process (GO:0003015)5.17917622
36heart contraction (GO:0060047)5.17917622
37heart trabecula formation (GO:0060347)5.16147270
38regulation of cell communication by electrical coupling (GO:0010649)5.11079110
39negative regulation of cardiac muscle cell apoptotic process (GO:0010667)5.05807585
40regulation of striated muscle contraction (GO:0006942)4.95073317
41regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.91013565
42carnitine shuttle (GO:0006853)4.86773151
43cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.78686112
44regulation of membrane repolarization (GO:0060306)4.75018441
45bundle of His cell to Purkinje myocyte communication (GO:0086069)4.75007983
46muscle hypertrophy (GO:0014896)4.59859732
47regulation of the force of heart contraction (GO:0002026)4.49490094
48negative regulation of striated muscle cell apoptotic process (GO:0010664)4.46146412
49cardiac ventricle formation (GO:0003211)4.44581359
50regulation of acyl-CoA biosynthetic process (GO:0050812)4.44476572
51cell communication involved in cardiac conduction (GO:0086065)4.37561289
52skeletal muscle contraction (GO:0003009)4.35264647
53response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.30253796
54mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.29861131
55ventricular cardiac muscle cell development (GO:0055015)4.24238257
56regulation of coenzyme metabolic process (GO:0051196)4.24216749
57regulation of cofactor metabolic process (GO:0051193)4.24216749
58cell communication by electrical coupling (GO:0010644)4.23469229
59cardiac muscle hypertrophy in response to stress (GO:0014898)4.20991051
60muscle hypertrophy in response to stress (GO:0003299)4.20991051
61cardiac muscle adaptation (GO:0014887)4.20991051
62regulation of cardioblast differentiation (GO:0051890)4.14594111
63ATP synthesis coupled proton transport (GO:0015986)4.14071444
64energy coupled proton transport, down electrochemical gradient (GO:0015985)4.14071444
65fatty acid transmembrane transport (GO:1902001)4.13686597
66muscle contraction (GO:0006936)3.98982359
67negative regulation of potassium ion transport (GO:0043267)3.97157259
68positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.94448623
69* striated muscle cell development (GO:0055002)3.89620910
70cardiac muscle cell action potential involved in contraction (GO:0086002)3.89152025
71membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.85164358
72cardiac muscle cell action potential (GO:0086001)3.84274118
73regulation of cardiac muscle contraction (GO:0055117)3.81435803
74oxidative phosphorylation (GO:0006119)3.79021025
75muscle system process (GO:0003012)3.70890391
76negative regulation of protein localization to cell surface (GO:2000009)3.68460848
77striated muscle adaptation (GO:0014888)3.67436553
78* regulation of heart rate (GO:0002027)3.66738103
79cardiac chamber formation (GO:0003207)3.64114385
80relaxation of cardiac muscle (GO:0055119)3.61152788
81negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.58046566
82muscle cell fate commitment (GO:0042693)3.57401207
83regulation of ATP catabolic process (GO:1903289)3.56652731
84regulation of ATPase activity (GO:0043462)3.56652731
85atrial septum morphogenesis (GO:0060413)3.56103881
86regulation of striated muscle cell apoptotic process (GO:0010662)3.55209764
87regulation of muscle contraction (GO:0006937)3.48341257
88respiratory electron transport chain (GO:0022904)3.47157756
89regulation of cardiac muscle cell contraction (GO:0086004)3.46948624
90trabecula formation (GO:0060343)3.45758373
91response to muscle activity (GO:0014850)3.45530762
92carnitine transmembrane transport (GO:1902603)3.43265710
93muscle fiber development (GO:0048747)3.42335335
94cardiac conduction (GO:0061337)3.41870757
95response to inactivity (GO:0014854)3.39756825
96regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.39326926
97* muscle cell development (GO:0055001)3.37058683
98regulation of potassium ion transmembrane transporter activity (GO:1901016)3.36919124
99electron transport chain (GO:0022900)3.36446330
100membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.34765242
101outflow tract septum morphogenesis (GO:0003148)3.32984818
102regulation of cardioblast proliferation (GO:0003264)3.32203788
103regulation of secondary heart field cardioblast proliferation (GO:0003266)3.32203788
104regulation of sulfur metabolic process (GO:0042762)3.31322858
105regulation of muscle system process (GO:0090257)3.30278870
106relaxation of muscle (GO:0090075)3.30256462
107positive regulation of cardiac muscle cell differentiation (GO:2000727)3.29517848
108* regulation of heart contraction (GO:0008016)3.27573554
109regulation of calcium ion transmembrane transport (GO:1903169)3.27496936
110regulation of calcium ion transmembrane transporter activity (GO:1901019)3.27496936
111regulation of heart rate by cardiac conduction (GO:0086091)3.27069362
112response to caffeine (GO:0031000)3.26409530
113regulation of skeletal muscle cell differentiation (GO:2001014)3.17222281
114negative regulation of cytosolic calcium ion concentration (GO:0051481)3.16244265
115myotube cell development (GO:0014904)3.12980263
116cardiac muscle tissue development (GO:0048738)3.11640557
117positive regulation of myoblast differentiation (GO:0045663)3.06699820
118negative regulation of calcium ion transmembrane transport (GO:1903170)3.05256965
119negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.05256965
120positive regulation of cation channel activity (GO:2001259)3.04795422
121skeletal muscle fiber development (GO:0048741)3.01512588
122regulation of cardiac muscle cell apoptotic process (GO:0010665)3.00541815
123skeletal muscle tissue development (GO:0007519)2.96836138
124muscle cell cellular homeostasis (GO:0046716)2.94534343
125regulation of myoblast differentiation (GO:0045661)2.86574163

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.95848271
2EP300_21415370_ChIP-Seq_HL-1_Mouse5.66125581
3* ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.46951499
4TBX20_22080862_ChIP-Seq_HEART_Mouse4.08041711
5TBX20_22328084_ChIP-Seq_HEART_Mouse4.08041711
6MEF2A_21415370_ChIP-Seq_HL-1_Mouse3.99022715
7ESR1_20079471_ChIP-ChIP_T-47D_Human3.59993555
8TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.52560978
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.30862205
10RARG_19884340_ChIP-ChIP_MEFs_Mouse3.01631069
11EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.89153734
12CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.86184871
13GATA4_21415370_ChIP-Seq_HL-1_Mouse2.82586124
14GBX2_23144817_ChIP-Seq_PC3_Human2.81353234
15ZNF263_19887448_ChIP-Seq_K562_Human2.75897531
16CDX2_19796622_ChIP-Seq_MESCs_Mouse2.30614305
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.19068055
18NKX2-5_21415370_ChIP-Seq_HL-1_Mouse2.15533533
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.12434520
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.11691415
21CLOCK_20551151_ChIP-Seq_293T_Human2.10138271
22WT1_19549856_ChIP-ChIP_CCG9911_Human2.04155333
23VDR_22108803_ChIP-Seq_LS180_Human2.03911980
24TRIM28_21343339_ChIP-Seq_HEK293_Human2.02012769
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00615589
26PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.96230935
27HIF1A_21447827_ChIP-Seq_MCF-7_Human1.89502909
28IGF1R_20145208_ChIP-Seq_DFB_Human1.85841070
29ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.77851441
30* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.76478645
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.74479923
32SMAD4_21799915_ChIP-Seq_A2780_Human1.72004454
33TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.71933271
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.71243888
35ISL1_27105846_Chip-Seq_CPCs_Mouse1.68631071
36RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.65942953
37NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.63742642
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57900564
39* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.57557330
40ZFP281_18757296_ChIP-ChIP_E14_Mouse1.57371975
41PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.56161567
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.54333133
43TAF15_26573619_Chip-Seq_HEK293_Human1.53919387
44* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.53779318
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.50509342
46FLI1_27457419_Chip-Seq_LIVER_Mouse1.50477440
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.50088247
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.49006521
49PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.48319772
50* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47610908
51FUS_26573619_Chip-Seq_HEK293_Human1.46672154
52ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.46484394
53JARID2_20064375_ChIP-Seq_MESCs_Mouse1.45975125
54PCGF2_27294783_Chip-Seq_NPCs_Mouse1.45691454
55NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.43860579
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.42929519
57NR3C1_21868756_ChIP-Seq_MCF10A_Human1.42401230
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.40734446
59CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.39221949
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38978111
61ZNF274_21170338_ChIP-Seq_K562_Hela1.37794656
62ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.37668674
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.37375032
64* P300_19829295_ChIP-Seq_ESCs_Human1.37244723
65ESR2_21235772_ChIP-Seq_MCF-7_Human1.36613363
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34376152
67TCF4_23295773_ChIP-Seq_U87_Human1.34253433
68TP53_16413492_ChIP-PET_HCT116_Human1.33548787
69STAT3_23295773_ChIP-Seq_U87_Human1.33318893
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33167430
71CJUN_26792858_Chip-Seq_BT549_Human1.33128150
72OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32350015
73WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.31707066
74RNF2_27304074_Chip-Seq_ESCs_Mouse1.31635370
75TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.29658562
76* EZH2_27294783_Chip-Seq_NPCs_Mouse1.29604712
77* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.28166552
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26613935
79JARID2_20075857_ChIP-Seq_MESCs_Mouse1.26327626
80BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.24554762
81EZH2_22144423_ChIP-Seq_EOC_Human1.24458773
82* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.23982407
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22882213
84RBPJ_22232070_ChIP-Seq_NCS_Mouse1.22689783
85TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21773551
86KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.21047706
87ATF3_27146783_Chip-Seq_COLON_Human1.20362956
88ELK3_25401928_ChIP-Seq_HUVEC_Human1.19994410
89* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.19276135
90SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.19015219
91TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.18713032
92NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18634403
93PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.18378162
94TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16631302
95KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16394251
96PPAR_26484153_Chip-Seq_NCI-H1993_Human1.16384908
97* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14249707
98KDM2B_26808549_Chip-Seq_DND41_Human1.13896354
99ER_23166858_ChIP-Seq_MCF-7_Human1.11537191
100* CRX_20693478_ChIP-Seq_RETINA_Mouse1.11514655
101* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.11465950
102TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.10482242
103RNF2_18974828_ChIP-Seq_MESCs_Mouse1.07605107
104EZH2_18974828_ChIP-Seq_MESCs_Mouse1.07605107
105* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.07280666
106BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07246576
107RACK7_27058665_Chip-Seq_MCF-7_Human1.06818589
108* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06324792
109NFE2_27457419_Chip-Seq_LIVER_Mouse1.04616002
110EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04507741
111DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.04153685
112CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03683423
113KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03171694
114TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01994102
115POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01994102
116TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01456931
117AR_21572438_ChIP-Seq_LNCaP_Human1.01037816
118ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.00792985
119DROSHA_22980978_ChIP-Seq_HELA_Human1.00631720
120UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00613034
121RNF2_27304074_Chip-Seq_NSC_Mouse0.99842524
122EZH2_27304074_Chip-Seq_ESCs_Mouse0.99446847
123AR_25329375_ChIP-Seq_VCAP_Human0.99234949
124CTCF_27219007_Chip-Seq_Bcells_Human0.99211716
125TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99127297
126TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98686969
127NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.93968445
128PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93789538
129SMC3_22415368_ChIP-Seq_MEFs_Mouse0.92710136
130* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.90900211
131RUNX1_27514584_Chip-Seq_MCF-7_Human0.88955989
132TP53_20018659_ChIP-ChIP_R1E_Mouse0.88819107
133SALL4_18804426_ChIP-ChIP_XEN_Mouse0.88556114
134* SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.88547096
135GATA1_19941826_ChIP-Seq_K562_Human0.87469576
136P300_27058665_Chip-Seq_ZR-75-30cells_Human0.86965815
137HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.84100041
138TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.83898749
139TP63_22573176_ChIP-Seq_HFKS_Human0.83867186
140WT1_25993318_ChIP-Seq_PODOCYTE_Human0.83468966
141ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.81387773
142TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80068484
143SMC1_22415368_ChIP-Seq_MEFs_Mouse0.79910168
144EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.79858525
145FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.79853431
146NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.78747306
147NRF2_20460467_ChIP-Seq_MEFs_Mouse0.78747306
148* TP53_23651856_ChIP-Seq_MEFs_Mouse0.78571141
149SOX2_21211035_ChIP-Seq_LN229_Gbm0.78434704
150AUTS2_25519132_ChIP-Seq_293T-REX_Human0.78399919
151SOX9_24532713_ChIP-Seq_HFSC_Mouse0.76658657
152SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.76547642
153TP53_22127205_ChIP-Seq_IMR90_Human0.75950571
154FOXH1_21741376_ChIP-Seq_ESCs_Human0.75531187
155UBF1/2_26484160_Chip-Seq_HMECs_Human0.75503852
156TBX5_21415370_ChIP-Seq_HL-1_Mouse0.75445628
157SMAD4_21741376_ChIP-Seq_HESCs_Human0.75424910
158SMAD3_21741376_ChIP-Seq_HESCs_Human0.73346911
159BCAT_22108803_ChIP-Seq_LS180_Human0.72841403
160PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.72620994
161KDM2B_26808549_Chip-Seq_K562_Human0.72160653
162ESR1_21235772_ChIP-Seq_MCF-7_Human0.71541250
163* EZH2_27294783_Chip-Seq_ESCs_Mouse0.71323095

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle5.92985277
2MP0002837_dystrophic_cardiac_calcinosis5.13824308
3MP0000751_myopathy5.02725368
4MP0000749_muscle_degeneration4.72910068
5MP0004036_abnormal_muscle_relaxation4.61815182
6MP0003646_muscle_fatigue4.42790006
7MP0004215_abnormal_myocardial_fiber4.21982690
8MP0005330_cardiomyopathy3.82519550
9MP0004145_abnormal_muscle_electrophysio3.69080889
10MP0004087_abnormal_muscle_fiber3.34701966
11MP0002972_abnormal_cardiac_muscle3.24139642
12MP0005620_abnormal_muscle_contractility3.03889345
13MP0008775_abnormal_heart_ventricle2.93238933
14* MP0002106_abnormal_muscle_physiology2.86734726
15MP0003137_abnormal_impulse_conducting2.73361885
16MP0010630_abnormal_cardiac_muscle2.66970090
17MP0002269_muscular_atrophy2.54486594
18MP0000747_muscle_weakness2.50833064
19* MP0000750_abnormal_muscle_regeneration2.47912764
20MP0001544_abnormal_cardiovascular_syste2.44412525
21MP0005385_cardiovascular_system_phenoty2.44412525
22MP0000759_abnormal_skeletal_muscle2.33871212
23MP0006138_congestive_heart_failure2.32770537
24* MP0005369_muscle_phenotype2.32326244
25MP0004233_abnormal_muscle_weight2.27661031
26MP0004484_altered_response_of2.23240951
27MP0003828_pulmonary_edema2.23085942
28MP0004130_abnormal_muscle_cell2.22559945
29MP0004085_abnormal_heartbeat2.01331917
30MP0003221_abnormal_cardiomyocyte_apopto1.95555063
31MP0002127_abnormal_cardiovascular_syste1.87773489
32MP0003950_abnormal_plasma_membrane1.84701246
33MP0003567_abnormal_fetal_cardiomyocyte1.80858945
34MP0004510_myositis1.55994201
35MP0006036_abnormal_mitochondrial_physio1.51061329
36MP0000733_abnormal_muscle_development1.46015628
37MP0002332_abnormal_exercise_endurance1.38989893
38MP0002234_abnormal_pharynx_morphology1.26266680
39MP0003279_aneurysm1.25852549
40MP0000266_abnormal_heart_morphology1.22887032
41MP0002102_abnormal_ear_morphology1.08094842
42MP0002108_abnormal_muscle_morphology1.07406108
43MP0004272_abnormal_basement_membrane1.04579014
44MP0003566_abnormal_cell_adhesion0.97310981
45MP0006035_abnormal_mitochondrial_morpho0.95166093
46MP0010368_abnormal_lymphatic_system0.94117262
47MP0001661_extended_life_span0.93141039
48MP0003705_abnormal_hypodermis_morpholog0.92959368
49MP0005623_abnormal_meninges_morphology0.91327604
50MP0003122_maternal_imprinting0.89761429
51MP0003283_abnormal_digestive_organ0.87614748
52MP0009780_abnormal_chondrocyte_physiolo0.87232609
53MP0001984_abnormal_olfaction0.87001066
54MP0002128_abnormal_blood_circulation0.86092053
55MP0005165_increased_susceptibility_to0.85101628
56MP0009384_cardiac_valve_regurgitation0.83786570
57MP0003136_yellow_coat_color0.81572795
58MP0005451_abnormal_body_composition0.81552268
59MP0000343_altered_response_to0.80855155
60MP0005666_abnormal_adipose_tissue0.79320566
61MP0008438_abnormal_cutaneous_collagen0.78474183
62MP0000767_abnormal_smooth_muscle0.75380687
63MP0003045_fibrosis0.73260503
64MP0001958_emphysema0.72554158
65MP0002638_abnormal_pupillary_reflex0.71947150
66MP0001879_abnormal_lymphatic_vessel0.69307696
67MP0003123_paternal_imprinting0.68569908
68MP0005266_abnormal_metabolism0.67766326
69MP0000372_irregular_coat_pigmentation0.67134764
70MP0000534_abnormal_ureter_morphology0.65830870
71MP0000230_abnormal_systemic_arterial0.65018854
72MP0002925_abnormal_cardiovascular_devel0.63646620
73MP0000013_abnormal_adipose_tissue0.63547712
74MP0002822_catalepsy0.62310316
75MP0006276_abnormal_autonomic_nervous0.61933855
76MP0005377_hearing/vestibular/ear_phenot0.61549740
77MP0003878_abnormal_ear_physiology0.61549740
78MP0004270_analgesia0.61316617
79MP0004147_increased_porphyrin_level0.59458325
80MP0002088_abnormal_embryonic_growth/wei0.58716923
81MP0001529_abnormal_vocalization0.58670005
82MP0003984_embryonic_growth_retardation0.58376986
83MP0004142_abnormal_muscle_tone0.58029945
84MP0010030_abnormal_orbit_morphology0.57722829
85MP0005375_adipose_tissue_phenotype0.57220178
86MP0004185_abnormal_adipocyte_glucose0.54952023
87MP0003385_abnormal_body_wall0.54155576
88MP0005275_abnormal_skin_tensile0.53596541
89MP0004134_abnormal_chest_morphology0.53468447
90MP0005171_absent_coat_pigmentation0.53178858
91MP0003937_abnormal_limbs/digits/tail_de0.51802288
92MP0001784_abnormal_fluid_regulation0.51650041
93MP0005386_behavior/neurological_phenoty0.51541447
94MP0004924_abnormal_behavior0.51541447
95MP0005503_abnormal_tendon_morphology0.49529252
96MP0001614_abnormal_blood_vessel0.49405567
97MP0002971_abnormal_brown_adipose0.45871578
98MP0000003_abnormal_adipose_tissue0.45382645
99MP0006072_abnormal_retinal_apoptosis0.44589871
100MP0001299_abnormal_eye_distance/0.41772647
101MP0003942_abnormal_urinary_system0.40794777
102MP0005253_abnormal_eye_physiology0.40031380
103MP0001672_abnormal_embryogenesis/_devel0.38592238
104MP0005380_embryogenesis_phenotype0.38592238
105MP0005670_abnormal_white_adipose0.37711775
106MP0002114_abnormal_axial_skeleton0.37073555
107MP0000049_abnormal_middle_ear0.36917797
108MP0002272_abnormal_nervous_system0.36770240
109MP0009250_abnormal_appendicular_skeleto0.35929012
110MP0003755_abnormal_palate_morphology0.35701822
111MP0003948_abnormal_gas_homeostasis0.35660973
112MP0005187_abnormal_penis_morphology0.33526908
113MP0009745_abnormal_behavioral_response0.33309244
114MP0003806_abnormal_nucleotide_metabolis0.32269112
115MP0000428_abnormal_craniofacial_morphol0.31190235
116MP0004197_abnormal_fetal_growth/weight/0.30393658
117MP0003941_abnormal_skin_development0.30172611
118MP0004043_abnormal_pH_regulation0.29993749
119MP0001727_abnormal_embryo_implantation0.29312879
120MP0002896_abnormal_bone_mineralization0.28860316
121MP0003121_genomic_imprinting0.28751990
122MP0001730_embryonic_growth_arrest0.27794579
123MP0009672_abnormal_birth_weight0.27604046
124MP0000762_abnormal_tongue_morphology0.27201161
125MP0003935_abnormal_craniofacial_develop0.26943278
126MP0001697_abnormal_embryo_size0.26937310
127MP0008961_abnormal_basal_metabolism0.25977423
128MP0005595_abnormal_vascular_smooth0.24972508
129MP0002078_abnormal_glucose_homeostasis0.24444743
130MP0005319_abnormal_enzyme/_coenzyme0.24221407

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)7.42229649
2Exercise-induced muscle cramps (HP:0003710)6.51205709
3Exercise-induced myalgia (HP:0003738)6.10108951
4Calf muscle hypertrophy (HP:0008981)5.86846593
5Subaortic stenosis (HP:0001682)5.66443300
6Abnormality of the left ventricular outflow tract (HP:0011103)5.66443300
7Muscle hypertrophy of the lower extremities (HP:0008968)5.62562506
8Ventricular tachycardia (HP:0004756)5.58864681
9Abnormality of the calf musculature (HP:0001430)5.31696219
10Type 1 muscle fiber predominance (HP:0003803)5.17233781
11Muscle fiber splitting (HP:0003555)5.15811343
12Atrial fibrillation (HP:0005110)5.12905218
13Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.11497929
14Muscle fiber inclusion bodies (HP:0100299)5.10764304
15Hyporeflexia of lower limbs (HP:0002600)4.89452423
16Primary atrial arrhythmia (HP:0001692)4.79260241
17Lipoatrophy (HP:0100578)4.66270771
18Supraventricular tachycardia (HP:0004755)4.63212519
19Myoglobinuria (HP:0002913)4.62555524
20Nemaline bodies (HP:0003798)4.55680416
21Supraventricular arrhythmia (HP:0005115)4.55254150
22EMG: myopathic abnormalities (HP:0003458)4.55131788
23Right ventricular cardiomyopathy (HP:0011663)4.24697576
24Syncope (HP:0001279)4.21844235
25Asymmetric septal hypertrophy (HP:0001670)3.96891688
26Ventricular arrhythmia (HP:0004308)3.95072457
27Dilated cardiomyopathy (HP:0001644)3.82294880
28Prolonged QT interval (HP:0001657)3.81907696
29Palpitations (HP:0001962)3.74765401
30Increased connective tissue (HP:0009025)3.70886014
31Rhabdomyolysis (HP:0003201)3.66110715
32Difficulty running (HP:0009046)3.51024548
33Myotonia (HP:0002486)3.50412696
34Distal arthrogryposis (HP:0005684)3.37209249
35Bundle branch block (HP:0011710)3.29210034
36Ventricular fibrillation (HP:0001663)3.24931717
37Difficulty climbing stairs (HP:0003551)3.08649216
38Neck muscle weakness (HP:0000467)3.02941076
39Muscle stiffness (HP:0003552)2.87229786
40Heart block (HP:0012722)2.86247877
41Centrally nucleated skeletal muscle fibers (HP:0003687)2.81604214
42Abnormal EKG (HP:0003115)2.80630274
43Atrioventricular block (HP:0001678)2.78909140
44Abnormal atrioventricular conduction (HP:0005150)2.76591711
45Mildly elevated creatine phosphokinase (HP:0008180)2.73575023
46Abnormality of skeletal muscle fiber size (HP:0012084)2.71053925
47Deformed tarsal bones (HP:0008119)2.70218778
48Round ear (HP:0100830)2.69010963
49Increased variability in muscle fiber diameter (HP:0003557)2.65909792
50Generalized muscle weakness (HP:0003324)2.64655585
51Ragged-red muscle fibers (HP:0003200)2.63631472
52Left ventricular hypertrophy (HP:0001712)2.63572193
53Myopathic facies (HP:0002058)2.61028511
54EMG: neuropathic changes (HP:0003445)2.54953423
55Abnormal finger flexion creases (HP:0006143)2.49712204
56Limited hip movement (HP:0008800)2.48133383
57Scapular winging (HP:0003691)2.46962394
58Distal lower limb muscle weakness (HP:0009053)2.42295320
59Gowers sign (HP:0003391)2.42080930
60Areflexia of lower limbs (HP:0002522)2.39018606
61Rimmed vacuoles (HP:0003805)2.29216529
62Abnormal mitochondria in muscle tissue (HP:0008316)2.26075335
63Ulnar deviation of the wrist (HP:0003049)2.22170059
64Double outlet right ventricle (HP:0001719)2.21510114
65Congenital malformation of the right heart (HP:0011723)2.21510114
66Conjunctival hamartoma (HP:0100780)2.20936796
67Acute necrotizing encephalopathy (HP:0006965)2.20414696
68Hypoplastic heart (HP:0001961)2.19802477
69Pheochromocytoma (HP:0002666)2.19496583
70Palmoplantar keratoderma (HP:0000982)2.17200626
71Limb-girdle muscle atrophy (HP:0003797)2.16505131
72Malignant hyperthermia (HP:0002047)2.10187625
73Abnormality of the foot musculature (HP:0001436)2.09549535
74Hepatic necrosis (HP:0002605)2.02765811
75Spinal rigidity (HP:0003306)2.00956885
76Slender build (HP:0001533)2.00626428
77Sudden cardiac death (HP:0001645)1.98025236
78Progressive muscle weakness (HP:0003323)1.97472649
79Fatigable weakness (HP:0003473)1.95727491
80Abnormality of the neuromuscular junction (HP:0003398)1.95727491
81Neoplasm of the adrenal gland (HP:0100631)1.94466519
82Aplasia of the musculature (HP:0100854)1.94300698
83Hypoplastic ischia (HP:0003175)1.93781632
84Absent phalangeal crease (HP:0006109)1.93045463
85Exercise intolerance (HP:0003546)1.92616805
86Type 2 muscle fiber atrophy (HP:0003554)1.92289344
87Calcaneovalgus deformity (HP:0001848)1.91476880
88Muscular dystrophy (HP:0003560)1.91258470
89Neuroendocrine neoplasm (HP:0100634)1.90685602
90Frequent falls (HP:0002359)1.88125685
91Hip contracture (HP:0003273)1.86669335
92Distal lower limb amyotrophy (HP:0008944)1.86133274
93Waddling gait (HP:0002515)1.84773442
94Weak cry (HP:0001612)1.82219707
95Hypoplastic left heart (HP:0004383)1.80258875
96Popliteal pterygium (HP:0009756)1.80012463
97Foot dorsiflexor weakness (HP:0009027)1.79918199
98Progressive macrocephaly (HP:0004481)1.79607350
99Bulbar palsy (HP:0001283)1.79339370
100Hypoglycemic coma (HP:0001325)1.79197774
101Abnormality of the shoulder girdle musculature (HP:0001435)1.79017919
102Bradycardia (HP:0001662)1.78596448
103Fetal akinesia sequence (HP:0001989)1.78183759
104Congestive heart failure (HP:0001635)1.77830135
105Increased serum pyruvate (HP:0003542)1.77732691
106Abnormality of glycolysis (HP:0004366)1.77732691
107Acute encephalopathy (HP:0006846)1.77577543
108Facial diplegia (HP:0001349)1.76816804
109Abnormality of the ischium (HP:0003174)1.72782277
110Limb-girdle muscle weakness (HP:0003325)1.69072030
111Steppage gait (HP:0003376)1.67776974
112Respiratory insufficiency due to muscle weakness (HP:0002747)1.66095185
113Hyperkalemia (HP:0002153)1.65298711
114Abnormality of the calcaneus (HP:0008364)1.63126808
115Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.59069239
116Infantile muscular hypotonia (HP:0008947)1.57843268
117Muscle fiber atrophy (HP:0100295)1.56486487
118Proximal amyotrophy (HP:0007126)1.55093710
119Metatarsus adductus (HP:0001840)1.51944959
120Preauricular pit (HP:0004467)1.48791391

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN6.24593767
2TTN4.91789436
3PKN23.99525841
4STK243.71286097
5MYLK3.55811362
6PHKG13.51946620
7PHKG23.51946620
8DMPK3.01803618
9PDK32.94491544
10PDK42.94491544
11NEK12.93378775
12TRIB32.89254809
13LMTK22.47254412
14PIK3CA2.06381620
15MUSK2.04956382
16ILK2.04841806
17MARK11.98047741
18LIMK11.70976828
19PDK21.67724170
20TIE11.62856676
21ZAK1.62661492
22CDC42BPA1.42487271
23FRK1.34049552
24BCKDK1.30687763
25MAP3K71.29650436
26PIK3CG1.27909773
27TRPM71.27239014
28PINK11.20603260
29ROCK11.16352941
30FLT31.14663489
31MAP2K31.12034155
32MAPK121.10873861
33BMPR1B1.07847023
34MAPKAPK31.06136924
35STK38L1.04904946
36PAK30.97679615
37PTK2B0.96925282
38CAMK2D0.94192047
39DDR20.92390646
40PRKD10.90512133
41EPHA30.86293146
42DAPK30.84238829
43EEF2K0.84067851
44PRKAA10.77982080
45NME10.76075021
46MAP3K100.75261637
47RIPK10.73103023
48WNK40.71871997
49PRKAA20.70663369
50PDGFRA0.68932836
51CASK0.68783801
52MAP3K50.68365756
53MAPK130.65944000
54NEK90.64119829
55ERBB30.63642379
56ROCK20.63639183
57ADRBK20.62653493
58MOS0.60136094
59PNCK0.59668392
60TESK10.58812105
61GRK70.55668311
62STK40.55086279
63MET0.54912621
64CAMK40.53954006
65AKT20.53566907
66CCNB10.53345604
67ADRBK10.53319030
68MAP4K20.51420773
69CAMK10.49567437
70KSR20.49189578
71KDR0.48243281
72WNK30.48112491
73CAMK1G0.47251759
74STK390.47150019
75GRK10.46967618
76MAP3K30.46673732
77CAMK2A0.45716559
78LATS20.45276329
79MAPK70.44935928
80PRKACB0.44910667
81AKT30.43628565
82SIK10.43577536
83PAK20.42422076
84MAP3K40.41680638
85WNK10.40223037
86TNIK0.39945715
87PRKD30.39501892
88PLK20.39155113
89PTK60.38394398
90LRRK20.38054710
91RET0.37884468
92DYRK1B0.37101384
93UHMK10.36048077
94CAMK2G0.35611170
95MAP2K10.35473497
96EPHB20.35287373
97CAMK2B0.34021078
98FGFR10.33999539
99LATS10.31663075
100INSRR0.30366338
101STK110.29727221
102PRKACA0.29520511
103NTRK30.28843237
104STK380.27861665
105EPHA40.27822127
106MAPK40.26920645
107FER0.26502464
108PTK20.25766357
109RPS6KL10.24666226
110RPS6KC10.24666226
111RPS6KA30.24545092
112MAP2K40.24472023
113MARK30.24356102
114PRKACG0.24331713
115MTOR0.24321040
116BRSK20.24075579
117PAK60.23620139
118SGK20.23234680
119NTRK20.23106602
120RPS6KA20.22582952
121PRKG10.22062558
122PRKG20.20738024
123NME20.20112551
124TGFBR20.19877891
125STK30.18594729
126MAPK110.16696042
127PKN10.16583028
128RPS6KB20.15375986
129PRKCE0.14970448
130ICK0.14188154
131RPS6KA60.13988268
132PDK10.13779000
133MAPKAPK20.13420355
134PDPK10.12960396

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.82509312
2Cardiac muscle contraction_Homo sapiens_hsa042604.77706482
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.28917903
4Dilated cardiomyopathy_Homo sapiens_hsa054144.17067865
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.94927023
6Parkinsons disease_Homo sapiens_hsa050123.11148363
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.07644772
8Oxidative phosphorylation_Homo sapiens_hsa001902.81031532
9Carbon metabolism_Homo sapiens_hsa012002.37703662
10Propanoate metabolism_Homo sapiens_hsa006402.37544220
11Alzheimers disease_Homo sapiens_hsa050102.23346210
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.18463792
13Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.17931934
14Fatty acid degradation_Homo sapiens_hsa000712.17180418
15Huntingtons disease_Homo sapiens_hsa050161.97919588
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.93706831
17Viral myocarditis_Homo sapiens_hsa054161.72149685
18Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.67706483
19Fatty acid metabolism_Homo sapiens_hsa012121.57827880
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.51531869
21Pyruvate metabolism_Homo sapiens_hsa006201.51157224
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.37766853
23Glucagon signaling pathway_Homo sapiens_hsa049221.35783749
24cGMP-PKG signaling pathway_Homo sapiens_hsa040221.31458947
25Starch and sucrose metabolism_Homo sapiens_hsa005001.26465890
26Biosynthesis of amino acids_Homo sapiens_hsa012301.25501283
27Insulin signaling pathway_Homo sapiens_hsa049101.22500535
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.19490582
29Insulin resistance_Homo sapiens_hsa049311.14833481
30Focal adhesion_Homo sapiens_hsa045101.14484958
31Tight junction_Homo sapiens_hsa045301.07140968
32HIF-1 signaling pathway_Homo sapiens_hsa040661.07020365
33Oxytocin signaling pathway_Homo sapiens_hsa049211.04149640
34Central carbon metabolism in cancer_Homo sapiens_hsa052301.03996745
35Galactose metabolism_Homo sapiens_hsa000521.00141821
36Protein digestion and absorption_Homo sapiens_hsa049740.98341608
37Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92517150
38Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.88152706
39Adipocytokine signaling pathway_Homo sapiens_hsa049200.85485812
40Phototransduction_Homo sapiens_hsa047440.84993945
41Calcium signaling pathway_Homo sapiens_hsa040200.83429424
42GABAergic synapse_Homo sapiens_hsa047270.83162267
43Vascular smooth muscle contraction_Homo sapiens_hsa042700.82414786
44Morphine addiction_Homo sapiens_hsa050320.82064652
45Salivary secretion_Homo sapiens_hsa049700.81638947
46AMPK signaling pathway_Homo sapiens_hsa041520.81512040
47Adherens junction_Homo sapiens_hsa045200.81209602
48Fatty acid elongation_Homo sapiens_hsa000620.80102386
49Nitrogen metabolism_Homo sapiens_hsa009100.77673827
50Taste transduction_Homo sapiens_hsa047420.71244079
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67917851
52Fructose and mannose metabolism_Homo sapiens_hsa000510.67735446
53ECM-receptor interaction_Homo sapiens_hsa045120.66587691
54Butanoate metabolism_Homo sapiens_hsa006500.65635549
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65199114
56Hedgehog signaling pathway_Homo sapiens_hsa043400.64039767
57Regulation of autophagy_Homo sapiens_hsa041400.63614379
58Linoleic acid metabolism_Homo sapiens_hsa005910.59156169
59Proteoglycans in cancer_Homo sapiens_hsa052050.58359643
60Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.58039904
61Glutamatergic synapse_Homo sapiens_hsa047240.56196109
62Circadian rhythm_Homo sapiens_hsa047100.55420056
63Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54262069
64Dopaminergic synapse_Homo sapiens_hsa047280.53894035
65Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53632458
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52776890
67Axon guidance_Homo sapiens_hsa043600.51283069
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50594953
69Serotonergic synapse_Homo sapiens_hsa047260.50228052
70Melanoma_Homo sapiens_hsa052180.49242896
71PPAR signaling pathway_Homo sapiens_hsa033200.49160548
72Amphetamine addiction_Homo sapiens_hsa050310.48920698
73Renin secretion_Homo sapiens_hsa049240.48750819
74Pancreatic secretion_Homo sapiens_hsa049720.47971495
75Lysine degradation_Homo sapiens_hsa003100.47766089
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47591345
77Type II diabetes mellitus_Homo sapiens_hsa049300.46939168
78Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46534047
79Long-term depression_Homo sapiens_hsa047300.46382264
80Amoebiasis_Homo sapiens_hsa051460.45630780
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.45032189
82Insulin secretion_Homo sapiens_hsa049110.42380693
83mTOR signaling pathway_Homo sapiens_hsa041500.42335634
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.42082912
85Gastric acid secretion_Homo sapiens_hsa049710.39858338
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39018831
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38327825
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.38142410
89Arginine and proline metabolism_Homo sapiens_hsa003300.37846328
90cAMP signaling pathway_Homo sapiens_hsa040240.37546117
91Bile secretion_Homo sapiens_hsa049760.36630864
92Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.36622683
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36283224
94Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.36157554
95Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.34939393
96Circadian entrainment_Homo sapiens_hsa047130.34579148
97GnRH signaling pathway_Homo sapiens_hsa049120.33354028
98Platelet activation_Homo sapiens_hsa046110.32530822
99FoxO signaling pathway_Homo sapiens_hsa040680.31954774
100Renal cell carcinoma_Homo sapiens_hsa052110.30638640
101Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.29837685
102Hippo signaling pathway_Homo sapiens_hsa043900.27139802
103Dorso-ventral axis formation_Homo sapiens_hsa043200.26227007
104Melanogenesis_Homo sapiens_hsa049160.25178886
105Arginine biosynthesis_Homo sapiens_hsa002200.22536481
106VEGF signaling pathway_Homo sapiens_hsa043700.22374408
107Gap junction_Homo sapiens_hsa045400.21677903
108beta-Alanine metabolism_Homo sapiens_hsa004100.21175662
109Aldosterone synthesis and secretion_Homo sapiens_hsa049250.21135750
110Phenylalanine metabolism_Homo sapiens_hsa003600.20310921
111Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.18993002
112Oocyte meiosis_Homo sapiens_hsa041140.18850793
113Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.17772817
114AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.16700107
115Cholinergic synapse_Homo sapiens_hsa047250.16686478
116Tryptophan metabolism_Homo sapiens_hsa003800.16556758
117Small cell lung cancer_Homo sapiens_hsa052220.16443170
118Fatty acid biosynthesis_Homo sapiens_hsa000610.16168905
119Endometrial cancer_Homo sapiens_hsa052130.14779251
120Olfactory transduction_Homo sapiens_hsa047400.14770894
121PI3K-Akt signaling pathway_Homo sapiens_hsa041510.14584834
122MAPK signaling pathway_Homo sapiens_hsa040100.14174772
123Thyroid cancer_Homo sapiens_hsa052160.12883820
124TGF-beta signaling pathway_Homo sapiens_hsa043500.11865845
125Basal cell carcinoma_Homo sapiens_hsa052170.11723306
126Ovarian steroidogenesis_Homo sapiens_hsa049130.10115350
127Metabolic pathways_Homo sapiens_hsa011000.09430770
128Rap1 signaling pathway_Homo sapiens_hsa040150.07912450
129Long-term potentiation_Homo sapiens_hsa047200.07374499
130Pathways in cancer_Homo sapiens_hsa052000.07292923

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