BUB1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid segregation (GO:0000070)6.19860363
2* protein localization to kinetochore (GO:0034501)5.80084017
3sister chromatid segregation (GO:0000819)5.65486817
4mitotic chromosome condensation (GO:0007076)5.48213262
5nuclear pore complex assembly (GO:0051292)5.43970806
6nuclear pore organization (GO:0006999)5.20964552
7DNA replication-dependent nucleosome organization (GO:0034723)5.18236260
8DNA replication-dependent nucleosome assembly (GO:0006335)5.18236260
9DNA unwinding involved in DNA replication (GO:0006268)4.97097798
10regulation of telomere maintenance via telomerase (GO:0032210)4.82872607
11daunorubicin metabolic process (GO:0044597)4.72201476
12polyketide metabolic process (GO:0030638)4.72201476
13doxorubicin metabolic process (GO:0044598)4.72201476
14* protein localization to chromosome, centromeric region (GO:0071459)4.68305599
15DNA replication checkpoint (GO:0000076)4.67869634
16negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.62852890
17DNA topological change (GO:0006265)4.59889084
18regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.52877991
19establishment of integrated proviral latency (GO:0075713)4.51445251
20regulation of nuclear cell cycle DNA replication (GO:0033262)4.50578224
21DNA ligation (GO:0006266)4.49356489
22heterochromatin organization (GO:0070828)4.38870715
23mitotic metaphase plate congression (GO:0007080)4.38743578
24chromatin assembly (GO:0031497)4.34119574
25negative regulation of cell cycle G2/M phase transition (GO:1902750)4.28954941
26mitotic nuclear envelope disassembly (GO:0007077)4.21600365
27DNA replication initiation (GO:0006270)4.21044611
28attachment of spindle microtubules to kinetochore (GO:0008608)4.20853209
29* negative regulation of chromosome segregation (GO:0051985)4.18560591
30pore complex assembly (GO:0046931)4.09952732
31DNA duplex unwinding (GO:0032508)4.09831302
32DNA geometric change (GO:0032392)4.08137978
33* negative regulation of mitotic sister chromatid separation (GO:2000816)4.06979271
34* negative regulation of sister chromatid segregation (GO:0033046)4.06979271
35* negative regulation of mitotic metaphase/anaphase transition (GO:0045841)4.06979271
36* negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)4.06979271
37* negative regulation of mitotic sister chromatid segregation (GO:0033048)4.06979271
38* mitotic spindle checkpoint (GO:0071174)4.04784269
39telomere maintenance via recombination (GO:0000722)4.01016981
40* regulation of metaphase/anaphase transition of cell cycle (GO:1902099)4.00963028
41* regulation of mitotic metaphase/anaphase transition (GO:0030071)4.00963028
42negative regulation of telomerase activity (GO:0051974)3.98430437
43* regulation of mitotic sister chromatid segregation (GO:0033047)3.94821412
44* regulation of sister chromatid segregation (GO:0033045)3.94821412
45* regulation of mitotic sister chromatid separation (GO:0010965)3.94821412
46membrane disassembly (GO:0030397)3.92770469
47nuclear envelope disassembly (GO:0051081)3.92770469
48pre-miRNA processing (GO:0031054)3.89453922
49* mitotic spindle assembly checkpoint (GO:0007094)3.89153225
50regulation of centriole replication (GO:0046599)3.87227536
51metaphase plate congression (GO:0051310)3.84661647
52notochord development (GO:0030903)3.72654120
53histone H4-K8 acetylation (GO:0043982)3.70046388
54histone H4-K5 acetylation (GO:0043981)3.70046388
55histone H4-K12 acetylation (GO:0043983)3.69832782
56kinetochore assembly (GO:0051382)3.69426388
57chromosome condensation (GO:0030261)3.69406334
58chromatin assembly or disassembly (GO:0006333)3.67368914
59negative regulation of epidermis development (GO:0045683)3.64223280
60positive regulation of DNA-dependent DNA replication (GO:2000105)3.64006051
61synapsis (GO:0007129)3.63961969
62microtubule depolymerization (GO:0007019)3.59781165
63maintenance of protein location in nucleus (GO:0051457)3.59364109
64regulation of centrosome cycle (GO:0046605)3.58284994
65regulation of mammary gland epithelial cell proliferation (GO:0033599)3.56336990
66non-recombinational repair (GO:0000726)3.54675162
67double-strand break repair via nonhomologous end joining (GO:0006303)3.54675162
68regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.53442456
69regulation of spindle organization (GO:0090224)3.51263737
70DNA strand elongation involved in DNA replication (GO:0006271)3.50725547
71folic acid-containing compound biosynthetic process (GO:0009396)3.49112946
72DNA conformation change (GO:0071103)3.48800618
73regulation of DNA endoreduplication (GO:0032875)3.47693927
74DNA synthesis involved in DNA repair (GO:0000731)3.46494705
75establishment of chromosome localization (GO:0051303)3.46271477
76chromosome segregation (GO:0007059)3.45867820
77negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.45489600
78rRNA transcription (GO:0009303)3.45450005
79regulation of gene silencing by RNA (GO:0060966)3.43708273
80regulation of posttranscriptional gene silencing (GO:0060147)3.43708273
81regulation of gene silencing by miRNA (GO:0060964)3.43708273
82IMP biosynthetic process (GO:0006188)3.43652722
83positive regulation of chromosome segregation (GO:0051984)3.42240123
84protein complex localization (GO:0031503)3.41689061
85kinetochore organization (GO:0051383)3.41081482
86nucleotide-excision repair, DNA gap filling (GO:0006297)3.40108300
87chromatin remodeling at centromere (GO:0031055)3.39226659
88regulation of translation in response to stress (GO:0043555)3.38136754
89formation of translation preinitiation complex (GO:0001731)3.37637585
90CENP-A containing nucleosome assembly (GO:0034080)3.36686244
91DNA strand elongation (GO:0022616)3.32240669
92DNA replication-independent nucleosome assembly (GO:0006336)3.31781768
93DNA replication-independent nucleosome organization (GO:0034724)3.31781768
94regulation of histone H3-K9 methylation (GO:0051570)3.30458603
95establishment of viral latency (GO:0019043)3.30361092
96negative regulation of histone methylation (GO:0031061)3.27684812
97regulation of mitotic spindle organization (GO:0060236)3.26555819
98* protein localization to chromosome (GO:0034502)3.25616579
99negative regulation of telomere maintenance (GO:0032205)3.24949120
100telomere maintenance via telomere lengthening (GO:0010833)3.24936252
101somite rostral/caudal axis specification (GO:0032525)3.24777900
102* negative regulation of mitosis (GO:0045839)3.21929106
103RNA stabilization (GO:0043489)3.17182940
104mRNA stabilization (GO:0048255)3.17182940
105meiotic chromosome segregation (GO:0045132)3.17178280
106purine nucleobase biosynthetic process (GO:0009113)3.16995833
107regulation of double-strand break repair (GO:2000779)3.16715319
108DNA packaging (GO:0006323)3.16277722
109regulation of sister chromatid cohesion (GO:0007063)3.16127886
110* regulation of chromosome segregation (GO:0051983)3.13639828
111spindle assembly (GO:0051225)3.13007782
112chromosome organization (GO:0051276)3.12503673
113* mitotic cell cycle (GO:0000278)3.12370220
114somatic hypermutation of immunoglobulin genes (GO:0016446)3.12165253
115somatic diversification of immune receptors via somatic mutation (GO:0002566)3.12165253
116mitotic sister chromatid cohesion (GO:0007064)3.12096600
117positive regulation of mitotic sister chromatid separation (GO:1901970)3.11411432
118positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.11411432
119positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.11411432
120IMP metabolic process (GO:0046040)3.11371883
121mitotic recombination (GO:0006312)3.09358576
122telomere maintenance via semi-conservative replication (GO:0032201)3.08735560
123sister chromatid cohesion (GO:0007062)3.08564753
124regulation of translational fidelity (GO:0006450)3.07051706
125ribosome biogenesis (GO:0042254)3.05319200
126mitotic spindle organization (GO:0007052)3.05287141
127resolution of meiotic recombination intermediates (GO:0000712)3.05233942
128regulation of centrosome duplication (GO:0010824)3.05174524
129protein K6-linked ubiquitination (GO:0085020)3.00295226
130mitotic G2/M transition checkpoint (GO:0044818)2.99338976
131histone exchange (GO:0043486)2.99297582
132nuclear envelope organization (GO:0006998)2.99022351
133* spindle checkpoint (GO:0031577)2.98958979
134rRNA methylation (GO:0031167)2.97275771
135regulation of response to osmotic stress (GO:0047484)2.95975460
136regulation of double-strand break repair via homologous recombination (GO:0010569)2.93654519
137regulation of DNA-dependent DNA replication (GO:0090329)2.93536667
138rRNA modification (GO:0000154)2.92704305
139histone H4-K16 acetylation (GO:0043984)2.87658501
140aminoglycoside antibiotic metabolic process (GO:0030647)2.87296537
141* spindle assembly checkpoint (GO:0071173)2.86364333
142ATP-dependent chromatin remodeling (GO:0043044)2.85820827

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.35686562
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.63816699
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.21277237
4* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.59899201
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.47992528
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.47992528
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.47992528
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.13653611
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.51553472
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.47272235
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.46726336
12TP63_19390658_ChIP-ChIP_HaCaT_Human2.45877751
13SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.38193777
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.38150536
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.28633128
16POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.26546169
17* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.23871285
18AR_21909140_ChIP-Seq_LNCAP_Human2.21839725
19* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.06271895
20* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.05352326
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.00257095
22* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.98620951
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.92202917
24NANOG_18555785_ChIP-Seq_MESCs_Mouse1.89819039
25MYC_22102868_ChIP-Seq_BL_Human1.88209180
26* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.82664241
27NELFA_20434984_ChIP-Seq_ESCs_Mouse1.79231202
28NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.78851902
29E2F1_21310950_ChIP-Seq_MCF-7_Human1.76248306
30TCF3_18692474_ChIP-Seq_MEFs_Mouse1.75390982
31CREB1_15753290_ChIP-ChIP_HEK293T_Human1.75301906
32* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.75080236
33POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.72111978
34SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.71633140
35TCF3_18692474_ChIP-Seq_MESCs_Mouse1.70260382
36* EST1_17652178_ChIP-ChIP_JURKAT_Human1.68164499
37STAT3_1855785_ChIP-Seq_MESCs_Mouse1.64999302
38POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.62072052
39XRN2_22483619_ChIP-Seq_HELA_Human1.60169829
40SOX2_18555785_ChIP-Seq_MESCs_Mouse1.54393490
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.51545980
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.51325766
43PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.48875670
44KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.47845647
45ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.46142289
46* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.42330469
47ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.41690730
48CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.41433266
49* ETS1_20019798_ChIP-Seq_JURKAT_Human1.41125293
50FOXP3_21729870_ChIP-Seq_TREG_Human1.40849498
51NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.39062527
52NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.37934491
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.36954347
54SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.34629521
55E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.33199956
56CIITA_25753668_ChIP-Seq_RAJI_Human1.32944725
57RBPJ_22232070_ChIP-Seq_NCS_Mouse1.32168085
58JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.30911423
59HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.28299079
60NANOG_21062744_ChIP-ChIP_HESCs_Human1.27994471
61KDM5A_27292631_Chip-Seq_BREAST_Human1.26478249
62GABP_17652178_ChIP-ChIP_JURKAT_Human1.25489209
63TTF2_22483619_ChIP-Seq_HELA_Human1.25473441
64VDR_23849224_ChIP-Seq_CD4+_Human1.24443097
65PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24215224
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22791236
67KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20586786
68YY1_21170310_ChIP-Seq_MESCs_Mouse1.19012184
69SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.18973151
70GABP_19822575_ChIP-Seq_HepG2_Human1.17689180
71SALL1_21062744_ChIP-ChIP_HESCs_Human1.16797392
72HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16119527
73ZFX_18555785_ChIP-Seq_MESCs_Mouse1.15836344
74ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12417315
75POU5F1_16518401_ChIP-PET_MESCs_Mouse1.11695447
76NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.09835971
77DCP1A_22483619_ChIP-Seq_HELA_Human1.08012554
78YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07521886
79* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07292402
80* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.06313094
81MYC_18940864_ChIP-ChIP_HL60_Human1.05605172
82POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.05582755
83HIF1A_21447827_ChIP-Seq_MCF-7_Human1.05009797
84SOX2_18692474_ChIP-Seq_MESCs_Mouse1.04099450
85* SOX2_16153702_ChIP-ChIP_HESCs_Human1.03664809
86KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03610580
87TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.02035272
88NANOG_18692474_ChIP-Seq_MEFs_Mouse1.01050527
89NANOG_18692474_ChIP-Seq_MESCs_Mouse1.00772468
90RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00522604
91SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00336227
92CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00044448
93THAP11_20581084_ChIP-Seq_MESCs_Mouse0.99638069
94TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.99349806
95ERG_20887958_ChIP-Seq_HPC-7_Mouse0.99208233
96OCT4_18692474_ChIP-Seq_MEFs_Mouse0.98043796
97* SOX17_20123909_ChIP-Seq_XEN_Mouse0.97598227
98CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.97071064
99ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96362614
100ELK1_19687146_ChIP-ChIP_HELA_Human0.96188180
101SOX2_18692474_ChIP-Seq_MEFs_Mouse0.95666438
102CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95106838
103* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94501661
104DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.90440050
105TFEB_21752829_ChIP-Seq_HELA_Human0.90107572
106IRF1_19129219_ChIP-ChIP_H3396_Human0.89201800
107SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.89133144
108ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.88561513
109* NANOG_16153702_ChIP-ChIP_HESCs_Human0.87523264
110HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.86525242
111PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.86146150
112PADI4_21655091_ChIP-ChIP_MCF-7_Human0.84819822
113VDR_21846776_ChIP-Seq_THP-1_Human0.82450289
114TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.80512938
115ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.80226709
116TCF7_22412390_ChIP-Seq_EML_Mouse0.80100719
117CHD1_26751641_Chip-Seq_LNCaP_Human0.79987629
118ELF1_17652178_ChIP-ChIP_JURKAT_Human0.79935811
119* POU5F1_16153702_ChIP-ChIP_HESCs_Human0.79234086
120* SRF_21415370_ChIP-Seq_HL-1_Mouse0.78163956
121TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.73491627
122DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.72283934
123EWS_26573619_Chip-Seq_HEK293_Human0.69565693
124HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.68514480
125CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.67708367

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004957_abnormal_blastocyst_morpholog4.16007503
2MP0008057_abnormal_DNA_replication4.12188730
3MP0003111_abnormal_nucleus_morphology3.78334358
4MP0003693_abnormal_embryo_hatching3.63381353
5* MP0010094_abnormal_chromosome_stability3.54396262
6* MP0003077_abnormal_cell_cycle3.35993961
7MP0004264_abnormal_extraembryonic_tissu2.93166068
8MP0010352_gastrointestinal_tract_polyps2.75547945
9MP0003890_abnormal_embryonic-extraembry2.70523175
10MP0003121_genomic_imprinting2.53135257
11MP0003123_paternal_imprinting2.47859271
12MP0006292_abnormal_olfactory_placode2.47287141
13MP0003705_abnormal_hypodermis_morpholog2.45639846
14MP0000350_abnormal_cell_proliferation2.38711072
15* MP0005380_embryogenesis_phenotype2.20526159
16* MP0001672_abnormal_embryogenesis/_devel2.20526159
17MP0003941_abnormal_skin_development2.18160839
18MP0001730_embryonic_growth_arrest2.17763350
19MP0008932_abnormal_embryonic_tissue2.16796174
20MP0008007_abnormal_cellular_replicative2.05147020
21MP0009697_abnormal_copulation2.03370674
22MP0003984_embryonic_growth_retardation2.01637818
23MP0002088_abnormal_embryonic_growth/wei2.00230496
24MP0003011_delayed_dark_adaptation1.99758949
25MP0008058_abnormal_DNA_repair1.98025294
26MP0002085_abnormal_embryonic_tissue1.87183557
27MP0002653_abnormal_ependyma_morphology1.86084518
28MP0002396_abnormal_hematopoietic_system1.82888124
29MP0010030_abnormal_orbit_morphology1.81386910
30MP0002084_abnormal_developmental_patter1.77347557
31MP0002086_abnormal_extraembryonic_tissu1.73295775
32MP0001697_abnormal_embryo_size1.71840578
33MP0002254_reproductive_system_inflammat1.67219797
34MP0005499_abnormal_olfactory_system1.66561207
35MP0005394_taste/olfaction_phenotype1.66561207
36MP0003122_maternal_imprinting1.59682988
37MP0004197_abnormal_fetal_growth/weight/1.57946084
38MP0001293_anophthalmia1.55167327
39MP0000490_abnormal_crypts_of1.51105349
40MP0005075_abnormal_melanosome_morpholog1.50627077
41* MP0002080_prenatal_lethality1.49029647
42MP0001849_ear_inflammation1.48828363
43MP0010307_abnormal_tumor_latency1.45201724
44MP0008877_abnormal_DNA_methylation1.38734415
45MP0003718_maternal_effect1.38372435
46* MP0000313_abnormal_cell_death1.34368160
47MP0005257_abnormal_intraocular_pressure1.29086790
48MP0002932_abnormal_joint_morphology1.26955138
49MP0003786_premature_aging1.22282965
50MP0005076_abnormal_cell_differentiation1.21487729
51MP0002092_abnormal_eye_morphology1.20973031
52MP0003315_abnormal_perineum_morphology1.18736986
53MP0003119_abnormal_digestive_system1.17706773
54MP0000678_abnormal_parathyroid_gland1.17034613
55MP0002009_preneoplasia1.16246929
56* MP0002019_abnormal_tumor_incidence1.15078657
57MP0003937_abnormal_limbs/digits/tail_de1.11366667
58MP0002332_abnormal_exercise_endurance1.09736405
59MP0000537_abnormal_urethra_morphology1.09305882
60MP0003938_abnormal_ear_development1.04081357
61MP0000428_abnormal_craniofacial_morphol1.03567390
62MP0006035_abnormal_mitochondrial_morpho1.01310184
63MP0002127_abnormal_cardiovascular_syste0.98938761
64MP0004858_abnormal_nervous_system0.97945351
65MP0002210_abnormal_sex_determination0.97943954
66MP0000432_abnormal_head_morphology0.97919331
67MP0004233_abnormal_muscle_weight0.96827500
68MP0003935_abnormal_craniofacial_develop0.95566955
69MP0004185_abnormal_adipocyte_glucose0.94885355
70MP0001145_abnormal_male_reproductive0.93924028
71MP0009703_decreased_birth_body0.93276380
72MP0004133_heterotaxia0.93105841
73MP0003787_abnormal_imprinting0.92557123
74MP0002938_white_spotting0.91957852
75MP0004808_abnormal_hematopoietic_stem0.91301023
76MP0002925_abnormal_cardiovascular_devel0.88735079
77MP0010234_abnormal_vibrissa_follicle0.88614715
78MP0002111_abnormal_tail_morphology0.88347492
79MP0000049_abnormal_middle_ear0.87750230
80* MP0003699_abnormal_female_reproductive0.85651005
81* MP0001929_abnormal_gametogenesis0.85162588
82MP0008789_abnormal_olfactory_epithelium0.83915198
83* MP0002114_abnormal_axial_skeleton0.83406019
84MP0003755_abnormal_palate_morphology0.83281983
85MP0000566_synostosis0.82886581
86MP0001346_abnormal_lacrimal_gland0.82871630
87MP0001915_intracranial_hemorrhage0.81554347
88MP0000653_abnormal_sex_gland0.80812472
89MP0001119_abnormal_female_reproductive0.80468105
90MP0005266_abnormal_metabolism0.80335366
91MP0001286_abnormal_eye_development0.80070876
92MP0002233_abnormal_nose_morphology0.78561473
93MP0003566_abnormal_cell_adhesion0.78480844
94MP0003136_yellow_coat_color0.77551696
95MP0005395_other_phenotype0.77213980
96* MP0002161_abnormal_fertility/fecundity0.77213118
97* MP0005384_cellular_phenotype0.76666969
98MP0000703_abnormal_thymus_morphology0.76561633
99MP0008770_decreased_survivor_rate0.76314830
100MP0001661_extended_life_span0.74796437
101* MP0003698_abnormal_male_reproductive0.74785257
102MP0005391_vision/eye_phenotype0.71634039
103MP0003861_abnormal_nervous_system0.70695197
104MP0005501_abnormal_skin_physiology0.70407533
105MP0002249_abnormal_larynx_morphology0.69601852
106MP0003567_abnormal_fetal_cardiomyocyte0.69438396
107MP0000762_abnormal_tongue_morphology0.69100487
108MP0000358_abnormal_cell_content/0.68009394
109MP0003385_abnormal_body_wall0.67288108
110MP0002160_abnormal_reproductive_system0.66092279
111MP0003221_abnormal_cardiomyocyte_apopto0.65146526
112MP0009672_abnormal_birth_weight0.65132039
113* MP0005621_abnormal_cell_physiology0.64420871
114MP0003283_abnormal_digestive_organ0.63888212
115MP0003115_abnormal_respiratory_system0.63041260
116* MP0002722_abnormal_immune_system0.62787570
117MP0001299_abnormal_eye_distance/0.62696768
118MP0002116_abnormal_craniofacial_bone0.62686711
119MP0003943_abnormal_hepatobiliary_system0.62662551
120MP0002697_abnormal_eye_size0.61876343
121MP0000477_abnormal_intestine_morphology0.59656090
122MP0001188_hyperpigmentation0.59424686
123MP0002877_abnormal_melanocyte_morpholog0.59310786
124* MP0005023_abnormal_wound_healing0.59107393
125MP0002796_impaired_skin_barrier0.58695022
126MP0000579_abnormal_nail_morphology0.58641928
127MP0001529_abnormal_vocalization0.57362905
128MP0008995_early_reproductive_senescence0.55838848
129MP0000647_abnormal_sebaceous_gland0.54452521

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.97762629
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.95104367
3Bilateral microphthalmos (HP:0007633)4.83771678
4Chromsome breakage (HP:0040012)4.82972387
5Hypochromic microcytic anemia (HP:0004840)4.32348777
6Rib fusion (HP:0000902)3.88749649
7Cortical dysplasia (HP:0002539)3.87804743
8Multiple enchondromatosis (HP:0005701)3.76376000
9* Increased nuchal translucency (HP:0010880)3.68873587
10Abnormality of the astrocytes (HP:0100707)3.56946352
11Astrocytoma (HP:0009592)3.56946352
12Impulsivity (HP:0100710)3.43495337
13Medulloblastoma (HP:0002885)3.42027299
14Meckel diverticulum (HP:0002245)3.39345062
15Hepatoblastoma (HP:0002884)3.31880504
16Abnormality of the lower motor neuron (HP:0002366)3.30786118
17Aplasia/Hypoplasia of the uvula (HP:0010293)3.24664083
18Abnormality of the ileum (HP:0001549)3.20562712
19Reticulocytopenia (HP:0001896)3.06259569
20Supernumerary spleens (HP:0009799)2.95463580
21Abnormality of chromosome stability (HP:0003220)2.88411226
22Aplasia/hypoplasia of the humerus (HP:0006507)2.88372011
23Glioma (HP:0009733)2.81806723
24Selective tooth agenesis (HP:0001592)2.81282244
25Premature ovarian failure (HP:0008209)2.80509732
26Short humerus (HP:0005792)2.80472716
27Volvulus (HP:0002580)2.71866677
28Fused cervical vertebrae (HP:0002949)2.68506671
29Abnormality of the labia minora (HP:0012880)2.67769132
30Abnormality of the preputium (HP:0100587)2.67706595
31* Neoplasm of striated muscle (HP:0009728)2.66046620
32Rectal fistula (HP:0100590)2.61583814
33Rectovaginal fistula (HP:0000143)2.61583814
34Abnormality of the salivary glands (HP:0010286)2.58416284
35Neoplasm of the oral cavity (HP:0100649)2.51527350
36Shawl scrotum (HP:0000049)2.49644091
37Trismus (HP:0000211)2.49111009
38Birth length less than 3rd percentile (HP:0003561)2.47850235
39* Rhabdomyosarcoma (HP:0002859)2.46259638
40Atresia of the external auditory canal (HP:0000413)2.43452199
41* Nephroblastoma (Wilms tumor) (HP:0002667)2.42754747
42Patellar aplasia (HP:0006443)2.42199866
43Preauricular skin tag (HP:0000384)2.41289518
44Aplasia/Hypoplasia of the sacrum (HP:0008517)2.38975793
45Intestinal fistula (HP:0100819)2.37712667
46Horseshoe kidney (HP:0000085)2.37356344
47Breast hypoplasia (HP:0003187)2.36325444
48Clubbing of toes (HP:0100760)2.35206121
49Missing ribs (HP:0000921)2.33978594
50Choanal atresia (HP:0000453)2.28552568
51Skin tags (HP:0010609)2.27538842
52Renal duplication (HP:0000075)2.26649838
53Microvesicular hepatic steatosis (HP:0001414)2.24404263
54Large earlobe (HP:0009748)2.24202267
55Absent radius (HP:0003974)2.22740351
56* Embryonal renal neoplasm (HP:0011794)2.22686919
57Aplasia/Hypoplasia of the patella (HP:0006498)2.21380762
58Progressive external ophthalmoplegia (HP:0000590)2.20289211
59* Small intestinal stenosis (HP:0012848)2.20249603
60* Duodenal stenosis (HP:0100867)2.20249603
61* Sloping forehead (HP:0000340)2.19209791
62Colon cancer (HP:0003003)2.18478878
63Amyotrophic lateral sclerosis (HP:0007354)2.17208315
64Abnormality of cochlea (HP:0000375)2.17096273
65Duplication of thumb phalanx (HP:0009942)2.16825292
66Bifid tongue (HP:0010297)2.12681326
67Vaginal fistula (HP:0004320)2.12375568
68Pendular nystagmus (HP:0012043)2.09548887
69Carpal bone hypoplasia (HP:0001498)2.09090930
70Deep philtrum (HP:0002002)2.08935522
71Arteriovenous malformation (HP:0100026)2.08624338
72Hypopigmentation of the fundus (HP:0007894)2.06616565
73Absent forearm bone (HP:0003953)2.06598240
74Aplasia involving forearm bones (HP:0009822)2.06598240
75* Abnormal lung lobation (HP:0002101)2.06009012
76High anterior hairline (HP:0009890)2.04016025
77* Neoplasm of the colon (HP:0100273)2.03660181
78Short 5th finger (HP:0009237)2.03604140
79Duplicated collecting system (HP:0000081)2.03325454
80* Myelodysplasia (HP:0002863)2.01964054
81Overlapping toe (HP:0001845)2.01094418
82Angiofibromas (HP:0010615)2.00229995
83Adenoma sebaceum (HP:0009720)2.00229995
84Agnosia (HP:0010524)1.99112659
85Bone marrow hypocellularity (HP:0005528)1.98990852
86Abnormality of the carotid arteries (HP:0005344)1.98883128
87Ectopic kidney (HP:0000086)1.98062339
88Atrophy/Degeneration involving motor neurons (HP:0007373)1.97394261
89* Embryonal neoplasm (HP:0002898)1.96958321
90Tracheoesophageal fistula (HP:0002575)1.96464114
91Prominent nose (HP:0000448)1.96118583
92Absent thumb (HP:0009777)1.95945282
93Abnormality of DNA repair (HP:0003254)1.95725974
94Hypochromic anemia (HP:0001931)1.95641086
95Abnormality of the distal phalanx of the thumb (HP:0009617)1.95606435
96Pseudobulbar signs (HP:0002200)1.94581297
97Hypoplasia of the fovea (HP:0007750)1.93771774
98Aplasia/Hypoplasia of the fovea (HP:0008060)1.93771774
99Supernumerary ribs (HP:0005815)1.92959541
100Malignant neoplasm of the central nervous system (HP:0100836)1.91703445
101Glossoptosis (HP:0000162)1.90469032
102Abnormality of the phalanges of the hallux (HP:0010057)1.90097451
103Proximal placement of thumb (HP:0009623)1.89742863
104Abnormal number of incisors (HP:0011064)1.88560770
105Deviation of the thumb (HP:0009603)1.87221856
106Facial hemangioma (HP:0000329)1.86170968
107Hypoplasia of the capital femoral epiphysis (HP:0003090)1.85809116
108Microretrognathia (HP:0000308)1.85359381
109Partial duplication of thumb phalanx (HP:0009944)1.84675841
110Short thumb (HP:0009778)1.84570416
111Supernumerary bones of the axial skeleton (HP:0009144)1.84100798
112Facial cleft (HP:0002006)1.84033878
113Vertebral fusion (HP:0002948)1.83415596
114Spinal muscular atrophy (HP:0007269)1.83180564
115Secondary amenorrhea (HP:0000869)1.81834156
116Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.81204792
117Broad palm (HP:0001169)1.81113728
118* Cafe-au-lait spot (HP:0000957)1.81082717
119* Abnormality of the duodenum (HP:0002246)1.80360652
120Spastic diplegia (HP:0001264)1.80278774
121Triphalangeal thumb (HP:0001199)1.79900422
122High pitched voice (HP:0001620)1.79763747
123Abnormality of abdominal situs (HP:0011620)1.79759201
124Abdominal situs inversus (HP:0003363)1.79759201
125Squamous cell carcinoma (HP:0002860)1.78099255
126Abnormality of glycolysis (HP:0004366)1.76221332
127Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.75886532
128Short 4th metacarpal (HP:0010044)1.75886532
129Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.69295484
130Shoulder girdle muscle weakness (HP:0003547)1.68676781
131Capillary hemangiomas (HP:0005306)1.67826817
132Progressive muscle weakness (HP:0003323)1.67419479
133Abnormality of the septum pellucidum (HP:0007375)1.66737465
134Microglossia (HP:0000171)1.66570717
135Irregular epiphyses (HP:0010582)1.65686968
136Abnormality of the renal collecting system (HP:0004742)1.65604531
137Poikiloderma (HP:0001029)1.65583255
138Biliary tract neoplasm (HP:0100574)1.64782340
139Neoplasm of the small intestine (HP:0100833)1.60068667
140Urethral obstruction (HP:0000796)1.59701125
141Cholecystitis (HP:0001082)1.58804832
142Abnormal gallbladder physiology (HP:0012438)1.58804832
143Obsessive-compulsive behavior (HP:0000722)1.57902890
144Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.57873291
145Absent epiphyses (HP:0010577)1.57873291
146Increased serum pyruvate (HP:0003542)1.56729390
147Morphological abnormality of the inner ear (HP:0011390)1.54999231
148Skull defect (HP:0001362)1.54439411

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.90374759
2CDC73.83369580
3STK103.29858579
4BUB13.05099618
5NEK22.85428103
6PBK2.76190673
7GRK62.71091286
8WEE12.68397077
9ERN12.42345708
10* TTK2.36527213
11GRK52.36011524
12ZAK2.14581874
13MOS2.10046222
14* PLK12.06848086
15CHEK22.05436207
16NEK12.04141732
17CDK71.99297864
18MAP3K101.93353227
19EEF2K1.86986096
20CSF1R1.86271698
21TYRO31.60857724
22RPS6KB21.59356148
23CCNB11.57680643
24AURKB1.56954321
25VRK21.48128623
26EPHA21.47421633
27CHEK11.45562582
28PAK41.43808220
29EIF2AK31.40984086
30PNCK1.37905603
31CDK41.35951490
32MAP3K81.35556060
33TAF11.35253503
34GRK11.32996074
35PLK41.30941082
36SRPK11.27847412
37MATK1.26332594
38BRSK21.24095630
39SMG11.22252356
40ATR1.20859025
41AURKA1.19730714
42TGFBR21.16732203
43ADRBK21.13362541
44STK41.06919581
45MAPK71.06833296
46EIF2AK11.06721176
47MST41.06323479
48MELK1.05196158
49ACVR1B1.00793641
50TESK21.00101826
51ATM0.98222986
52CDK20.96914278
53ALK0.95951837
54PASK0.89738493
55PLK30.89001587
56MET0.83289956
57BRSK10.83211599
58PKN20.82832023
59MTOR0.81605647
60TRIM280.80300398
61TLK10.78168787
62BRD40.77427701
63WNK10.75399591
64LATS20.75051620
65STK30.72943737
66TSSK60.72016532
67AKT20.71137115
68* CDK10.69248864
69DYRK30.65749484
70ERBB40.64763449
71LRRK20.62131113
72STK160.61478454
73MKNK10.61409213
74PAK10.60459694
75SCYL20.60367059
76LATS10.59396606
77PRKG20.58789397
78MAPKAPK30.58701534
79GRK70.58597690
80NUAK10.57336845
81CAMK40.56527117
82PRKCI0.55037476
83MAP3K90.54938850
84CDK60.54852020
85NME20.54762418
86HIPK20.52453178
87VRK10.52007996
88PIM10.51833152
89EIF2AK20.51739602
90ADRBK10.51392672
91MST1R0.50679954
92CDK11A0.50252732
93CAMK1G0.50048429
94FGFR10.49884294
95CDK180.49788838
96CDK80.49751991
97CDK150.49427826
98FLT30.47885788
99TNIK0.47410532
100FGFR30.47383368
101NME10.46596121
102PRKDC0.43339404
103BRAF0.42653830
104RPS6KA40.42385468
105CSNK1E0.41848193
106CDK140.39987175
107TGFBR10.38983443
108RAF10.38161256
109MARK20.37200124
110AKT30.36866273
111CSNK1D0.36766140
112PLK20.36585025
113MAPK140.36392297
114PDK20.34562356
115STK38L0.34374388
116CDK30.34123298
117MAPK10.31848466
118BCR0.31513699
119PDGFRA0.30521432
120KSR10.29556376
121NEK90.29412718
122CSK0.29220275
123CAMK1D0.28745234
124GSK3B0.28219171
125STK240.27779708
126TRIB30.27638292
127CDK190.27094925
128NTRK10.27058609
129MKNK20.26540271
130CLK10.26514448
131AKT10.26441184
132CSNK2A20.26082642
133BMX0.25488411
134PAK20.24842021
135CSNK2A10.24552998
136CSNK1G10.24374934
137MARK30.24263830
138CDK90.24214651
139ICK0.24150121

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.41901190
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.07313704
3Mismatch repair_Homo sapiens_hsa034303.91820191
4RNA transport_Homo sapiens_hsa030133.17276824
5* Cell cycle_Homo sapiens_hsa041103.10728970
6Homologous recombination_Homo sapiens_hsa034402.90681797
7Base excision repair_Homo sapiens_hsa034102.81976550
8Vitamin B6 metabolism_Homo sapiens_hsa007502.80495700
9Fanconi anemia pathway_Homo sapiens_hsa034602.70067787
10Spliceosome_Homo sapiens_hsa030402.67687476
11One carbon pool by folate_Homo sapiens_hsa006702.61521534
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.30362916
13Nucleotide excision repair_Homo sapiens_hsa034202.27293291
14mRNA surveillance pathway_Homo sapiens_hsa030152.26964854
15Non-homologous end-joining_Homo sapiens_hsa034502.16198083
16RNA degradation_Homo sapiens_hsa030182.11746743
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.79535595
18Ribosome_Homo sapiens_hsa030101.74285116
19p53 signaling pathway_Homo sapiens_hsa041151.69892024
20RNA polymerase_Homo sapiens_hsa030201.65105384
21Basal transcription factors_Homo sapiens_hsa030221.64489455
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.59108761
23Fructose and mannose metabolism_Homo sapiens_hsa000511.55178538
24Pyrimidine metabolism_Homo sapiens_hsa002401.40405816
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.39279548
26MicroRNAs in cancer_Homo sapiens_hsa052061.32294798
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.32258057
28Systemic lupus erythematosus_Homo sapiens_hsa053221.32104968
29Oocyte meiosis_Homo sapiens_hsa041141.28598840
30Thyroid cancer_Homo sapiens_hsa052161.22361231
31Pyruvate metabolism_Homo sapiens_hsa006201.22179644
32Viral carcinogenesis_Homo sapiens_hsa052031.15170354
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.14087815
34Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.09918975
35Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.07158984
36mTOR signaling pathway_Homo sapiens_hsa041501.06392411
37Transcriptional misregulation in cancer_Homo sapiens_hsa052021.05846819
38Galactose metabolism_Homo sapiens_hsa000521.00310636
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.99599712
40Steroid biosynthesis_Homo sapiens_hsa001000.98428835
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.94910632
42Herpes simplex infection_Homo sapiens_hsa051680.94528117
43Basal cell carcinoma_Homo sapiens_hsa052170.90660046
44Proteasome_Homo sapiens_hsa030500.87737718
45Hippo signaling pathway_Homo sapiens_hsa043900.84047046
46Arachidonic acid metabolism_Homo sapiens_hsa005900.81985247
47Protein export_Homo sapiens_hsa030600.80939013
48* HTLV-I infection_Homo sapiens_hsa051660.80389702
49Small cell lung cancer_Homo sapiens_hsa052220.80292180
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79835986
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78190366
52Propanoate metabolism_Homo sapiens_hsa006400.77377350
53Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.76903314
54Notch signaling pathway_Homo sapiens_hsa043300.74581362
55Colorectal cancer_Homo sapiens_hsa052100.73352494
56Linoleic acid metabolism_Homo sapiens_hsa005910.73277178
57Biosynthesis of amino acids_Homo sapiens_hsa012300.71761910
58Central carbon metabolism in cancer_Homo sapiens_hsa052300.71482203
59Epstein-Barr virus infection_Homo sapiens_hsa051690.70755600
60Pentose phosphate pathway_Homo sapiens_hsa000300.70127296
61Hedgehog signaling pathway_Homo sapiens_hsa043400.69098154
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66343830
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65654375
64Selenocompound metabolism_Homo sapiens_hsa004500.65502598
65Pathways in cancer_Homo sapiens_hsa052000.64062250
66Adherens junction_Homo sapiens_hsa045200.62719830
67Bladder cancer_Homo sapiens_hsa052190.59305949
68Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58757641
69Antigen processing and presentation_Homo sapiens_hsa046120.58485693
70Purine metabolism_Homo sapiens_hsa002300.58472768
71N-Glycan biosynthesis_Homo sapiens_hsa005100.58390662
72Pancreatic cancer_Homo sapiens_hsa052120.58165765
73Fatty acid elongation_Homo sapiens_hsa000620.58089461
74TGF-beta signaling pathway_Homo sapiens_hsa043500.57915377
75Apoptosis_Homo sapiens_hsa042100.57452862
76Non-small cell lung cancer_Homo sapiens_hsa052230.56732818
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.56309842
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54363788
79Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53535608
80Alcoholism_Homo sapiens_hsa050340.50559939
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48924463
82Chronic myeloid leukemia_Homo sapiens_hsa052200.48460654
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48271842
84Lysine degradation_Homo sapiens_hsa003100.47749857
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47584243
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47562199
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46748967
88Ovarian steroidogenesis_Homo sapiens_hsa049130.46162186
89Acute myeloid leukemia_Homo sapiens_hsa052210.45467817
90Proteoglycans in cancer_Homo sapiens_hsa052050.43506710
91Glutathione metabolism_Homo sapiens_hsa004800.41150516
92Folate biosynthesis_Homo sapiens_hsa007900.39089696
93Primary immunodeficiency_Homo sapiens_hsa053400.38885045
94Sulfur relay system_Homo sapiens_hsa041220.38365182
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37907718
96Cyanoamino acid metabolism_Homo sapiens_hsa004600.37199750
97Wnt signaling pathway_Homo sapiens_hsa043100.34154730
98Huntingtons disease_Homo sapiens_hsa050160.32998796
99RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.32595577
100Tight junction_Homo sapiens_hsa045300.32324076
101Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.32196721
102Carbon metabolism_Homo sapiens_hsa012000.32086652
103Leukocyte transendothelial migration_Homo sapiens_hsa046700.31751848
104Inositol phosphate metabolism_Homo sapiens_hsa005620.30211637
105Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.29276543
106Legionellosis_Homo sapiens_hsa051340.27862659
107Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.26766374
108Hepatitis B_Homo sapiens_hsa051610.26048958
109NF-kappa B signaling pathway_Homo sapiens_hsa040640.25908551
110AMPK signaling pathway_Homo sapiens_hsa041520.25854209
111Fatty acid metabolism_Homo sapiens_hsa012120.24823145
112HIF-1 signaling pathway_Homo sapiens_hsa040660.24382524
113Melanoma_Homo sapiens_hsa052180.24035074
114Influenza A_Homo sapiens_hsa051640.23837838
115Arginine and proline metabolism_Homo sapiens_hsa003300.23057116
116VEGF signaling pathway_Homo sapiens_hsa043700.22912274
117Metabolic pathways_Homo sapiens_hsa011000.22825177
118Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.22558679
119Prostate cancer_Homo sapiens_hsa052150.22250410
120PI3K-Akt signaling pathway_Homo sapiens_hsa041510.21207672
121Endometrial cancer_Homo sapiens_hsa052130.20846258
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.19261182
123Drug metabolism - other enzymes_Homo sapiens_hsa009830.18914678
124Viral myocarditis_Homo sapiens_hsa054160.17922795
125Other glycan degradation_Homo sapiens_hsa005110.17887135
126Rap1 signaling pathway_Homo sapiens_hsa040150.17636858
127Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.16129602
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.13305716
129Arginine biosynthesis_Homo sapiens_hsa002200.12662116

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